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Margriet Ouwens

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Chemicals & Drugs

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Glucose Clamp Technique

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Wilco W M Fleuren; Bruno Guigas; Margot M L Linssen; D Margriet Ouwens; Erik J M Toonen; Gerard C M van der Zon; Jacob de Vlieg; Wim H A Dokter; Wynand Alkema
Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes.
C Wiza; H Al-Hasani; D Herzfeld de Wiza; S Lehr; E B M Nascimento; D Margriet Ouwens
Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.
Laura K M Steinbusch; Guillaume van Eys; Benoit Viollet; D Margriet Ouwens; Veronique Roelants; Luc Bertrand; Michaela Diamant; Ellen Dirkx; Marc Foretz; Jan F C Glatz; Nicole T H Hoebers; Joost J F P Luiken
Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.

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2013: Wilco W M Fleuren; Bruno Guigas; Margot M L Linssen; D Margriet Ouwens; Erik J M Toonen; Gerard C M van der Zon; Jacob de Vlieg; Wim H A Dokter; Wynand Alkema
Prednisolone induces the Wnt signalling pathway in 3T3-L1 adipocytes.
Archives of physiology and biochemistry 2013;119(2):52-64.
2013: C Wiza; H Al-Hasani; D Herzfeld de Wiza; S Lehr; E B M Nascimento; D Margriet Ouwens
Knockdown of PRAS40 inhibits insulin action via proteasome-mediated degradation of IRS1 in primary human skeletal muscle cells.
Diabetologia 2013;56(5):1118-28.
2013: Laura K M Steinbusch; Guillaume van Eys; Benoit Viollet; D Margriet Ouwens; Veronique Roelants; Luc Bertrand; Michaela Diamant; Ellen Dirkx; Marc Foretz; Jan F C Glatz; Nicole T H Hoebers; Joost J F P Luiken
Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.
Journal of molecular and cellular cardiology 2013;55():165-73.
2013: Sabrina Greulich; Jacqueline T Jonker; Hildo J Lamb; Artur Lichtenberg; Bujar Maxhera; Heidi Mueller; Luuk J Rijzewijk; Johannes A Romijn; Konstantinos Smiris; Jan W A Smit; Rutger W van der Meer; Payam Akhyari; Jeroen J Bax; Weena J Y Chen; Albert de Roos; Daniella Herzfeld de Wiza; Michaela Diamant; Juergen Eckel; Ralf-Ruediger Floerke; D Margriet Ouwens
Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies.
PloS one 2013;8(3):e59697.
2012: Yeliz Angin; Will A Coumans; Michaela Diamant; Kim Douma; Jan F C Glatz; Sabrina Greulich; Nicole T H Hoebers; D Margriet Ouwens; Peter J Simons; Laura K M Steinbusch; Marc A M J van Zandvoort; Wino Wijnen; Joost J F P Luiken
CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes.
The Biochemical journal 2012;448(1):43-53.
2012: Sabrina Greulich; Jessica Heinrichs; Bujar Maxhera; Heidi Mueller; D Margriet Ouwens; Johannes B Ruige; Konstantinos Smiris; Guy Vandenplas; Payam Akhyari; Marcel Blumensatt; Claude Cuvelier; Daniella Herzfeld de Wiza; Jürgen Eckel
Secretory products from epicardial adipose tissue of patients with type 2 diabetes mellitus induce cardiomyocyte dysfunction.
Circulation 2012;126(19):2324-34.
2012: Esther Phielix; Gert Schaart; Lauren Sparks; Matthijs K C Hesselink; Joris Hoeks; Ruth Meex; Esther Moonen-Kornips; D Margriet Ouwens; Patrick Schrauwen
High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.
Diabetes 2012;61(10):2472-8.
2012: Guy Vandenplas; P Calders; Dirk De Bacquer; Tom Fiers; Jean-Marc Kaufman; D Margriet Ouwens; Johannes B Ruige
Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies.
Heart (British Cardiac Society) 2012;98(20):1478-82.
2012: Marieke Snel; Emma Buzzigoli; Marijke Frölich; Amalia Gastaldelli; Matthijs K C Hesselink; A Edo Meinders; D Margriet Ouwens; Hanno Pijl; Johannes A Romijn; Gert Schaart; Ingrid M Jazet
Effects of adding exercise to a 16-week very low-calorie diet in obese, insulin-dependent type 2 diabetes mellitus patients.
The Journal of clinical endocrinology and metabolism 2012;97(7):2512-20.
2012: Johannes B Ruige; Martina Schiller; Goverdhan Puchchakayala; Youri E C Taes; Yves Van Nieuwenhove; Waltraud Passlack; Piet Pattyn; Marlies Bekaert; Claude Cuvelier; Jürgen Eckel; Tom Fiers; Sonja Hartwig; Daniella Herzfeld de Wiza; Jean-Marc Kaufman; Bruno Lapauw; Stefan Lehr; D Margriet Ouwens
Sex steroid-induced changes in circulating monocyte chemoattractant protein-1 levels may contribute to metabolic dysfunction in obese men.
The Journal of clinical endocrinology and metabolism 2012;97(7):E1187-91.
2012: D Margriet Ouwens; Goverdhan Puchchakayala; Yves Van Nieuwenhove; Marlies Bekaert; Patrick Calders; Jürgen Eckel; Sonja Hartwig; Jean-Marc Kaufman; Bruno Lapauw; Stefan Lehr; Johannes B Ruige
Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome.
Archives of physiology and biochemistry 2012;118(3):135-8.
2012: Claudia Wiza; Emmani B M Nascimento; D Margriet Ouwens
Role of PRAS40 in Akt and mTOR signaling in health and disease.
American journal of physiology. Endocrinology and metabolism 2012;302(12):E1453-60.
2012: Tina Märker; D Margriet Ouwens; Piet Pattyn; Michael Roden; Johannes Ruige; Henrike Sell; Pia Zillessen; Jürgen Eckel; Susanne Famulla; Anja Glöde; Jennifer Kriebel; Christiane Habich
Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance.
Diabetes 2012;61(3):615-25.
2012: Margot Berings; Ellen Deschepper; Jean-Marc Kaufman; Ilse Mertens; D Margriet Ouwens; Luc F Van Gaal; An Verrijken; Charline Wehlou; Johannes B Ruige
Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females.
PloS one 2012;7(9):e45145.
2011: Margot M L Linssen; Erik J M Toonen; Gerard C M van der Zon; Daniel H van Raalte; Wynand Alkema; Michaela Diamant; Wim H Dokter; Bruno Guigas; D Margriet Ouwens
Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells.
Cellular signalling 2011;23(11):1708-15.
2011: Sabrina Greulich; Kornelia Jaquet; Dominique Langin; Heidi Mueller; D Margriet Ouwens; Sebastian Preilowski; Daniella Herzfeld de Wiza; Zhaoping Ding; Juergen Eckel
Secretory products of guinea pig epicardial fat induce insulin resistance and impair primary adult rat cardiomyocyte function.
Journal of cellular and molecular medicine 2011;15(11):2399-410.
2011: Laura K M Steinbusch; Ronald Vlasblom; Peter J Voshol; Irene O C M Vroegrijk; Jan F C Glatz; Nicole T H Hoebers; Joost J F P Luiken; D Margriet Ouwens; Adrian Chabowski; Will A Coumans; Michaela Diamant
Absence of fatty acid transporter CD36 protects against Western-type diet-related cardiac dysfunction following pressure overload in mice.
American journal of physiology. Endocrinology and metabolism 2011;301(4):E618-27.
2011: Claudia P Coomans; Janine J Geerling; Bruno Guigas; Louis M Havekes; D Margriet Ouwens; Edwin T Parlevliet; Hanno Pijl; Patrick C N Rensen; Anita M van den Hoek; Peter J Voshol; Johannes A Romijn
Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice.
Journal of lipid research 2011;52(9):1712-22.
2011: Laura K M Steinbusch; Michaela Diamant; Jan F C Glatz; D Margriet Ouwens; Robert W Schwenk; Joost J F P Luiken
Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes.
Cellular and molecular life sciences : CMLS 2011;68(15):2525-38.
2011: Daniela Lamers; Stefan Lehr; Stefan Müller; D Margriet Ouwens; Johannes Ruige; Mikael Ryden; Henrike Sell; Nina Wronkowitz; Susanne Famulla; Franz-Georg Hanisch; Sonja Hartwig; Jean M Kaufman; Peter Arner; Kristin Eckardt; Juergen Eckel
Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome.
Diabetes 2011;60(7):1917-25.
2011: Daniël H van Raalte; Renate E van Genugten; Margot M L Linssen; D Margriet Ouwens; Michaela Diamant
Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans.
Diabetes care 2011;34(2):412-7.
2010: D Margriet Ouwens; Goverdhan Puchchakayala; Sabrina Greulich; Juergen Eckel
The role of epicardial and perivascular adipose tissue in the pathophysiology of cardiovascular disease.
Journal of cellular and molecular medicine 2010;14(9):2223-34.
2010: J E de Leeuw van Weenen; E T Parlevliet; Pierre Maechler; Louis M Havekes; Johannes A Romijn; D Margriet Ouwens; Hanno Pijl; Bruno Guigas
The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells.
Biochemical pharmacology 2010;79(12):1827-36.
2010: Laura K M Steinbusch; Wino Wijnen; Robert W Schwenk; Will A Coumans; Nicole T H Hoebers; D Margriet Ouwens; Will A Coumans; Nicole T H Hoebers; Michaela Diamant; Arend Bonen; Jan F C Glatz; Joost J F P Luiken
Differential regulation of cardiac glucose and fatty acid uptake by endosomal pH and actin filaments.
American journal of physiology. Cell physiology 2010;298(6):C1549-59.
2010: Emmani B M Nascimento; Marieke Snel; Bruno Guigas; Gerard C M van der Zon; Jan Kriek; J Antonie Maassen; Ingrid M Jazet; Michaela Diamant; D Margriet Ouwens
Phosphorylation of PRAS40 on Thr246 by PKB/AKT facilitates efficient phosphorylation of Ser183 by mTORC1.
Cellular signalling 2010;22(6):961-7.
2009: Bart Baan; Gerard C M van der Zon; J Antonie Maassen; D Margriet Ouwens
The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells.
Molecular and cellular endocrinology 2009;311(1-2):94-100.
2009: Emmani B M Nascimento; D Margriet Ouwens
PRAS40: target or modulator of mTORC1 signalling and insulin action?
Archives of physiology and biochemistry 2009;115(4):163-75.
2009: Lars Verschuren; Teake Kooistra; Jürgen Bernhagen; Peter J Voshol; D Margriet Ouwens; Marjan van Erk; Jitske de Vries-van der Weij; Lin Leng; J Hajo van Bockel; Ko Willems van Dijk; Günter Fingerle-Rowson; Rick Bucala; Robert Kleemann
MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease.
Circulation research 2009;105(1):99-107.
2009: Joost J F P Luiken; D Margriet Ouwens; Daphna D J Habets; Gerard C M van der Zon; Will A Coumans; Robert W Schwenk; Arend Bonen; Jan F C Glatz
Permissive action of protein kinase C-zeta in insulin-induced CD36- and GLUT4 translocation in cardiac myocytes.
The Journal of endocrinology 2009;201(2):199-209.
2009: D H van Raalte; D Margriet Ouwens; Michaela Diamant
Novel insights into glucocorticoid-mediated diabetogenic effects: towards expansion of therapeutic options?
European journal of clinical investigation 2009;39(2):81-93.
2009: Charissa E van den Brom; Marc C Huisman; Ronald Vlasblom; Nicky M Boontje; Suzanne Duijst; Mark Lubberink; Carla F M Molthoff; Adriaan A Lammertsma; Jolanda van der Velden; Christa Boer; D Margriet Ouwens; Michaela Diamant
Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography.
Cardiovascular diabetology 2009;8():39.
2008: Anita M van den Hoek; Caroline Van Heijningen; Janny P Schröder-van der Elst; D Margriet Ouwens; Louis M Havekes; Johannes A Romijn; Andries Kalsbeek; Hanno Pijl
Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation.
Diabetes 2008;57(9):2304-10.
2008: Ingrid M Jazet; Gert Schaart; A Gastaldelli; E Ferrannini; M K Hesselink; patrick schrauwen; Johannes A Romijn; J Antonie Maassen; Hanno Pijl; D Margriet Ouwens; A Edo Meinders
Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients.
Diabetologia 2008;51(2):309-19.
2007: J Antonie Maassen; Leen M 't Hart; D Margriet Ouwens
Lessons that can be learned from patients with diabetogenic mutations in mitochondrial DNA: implications for common type 2 diabetes.
Current opinion in clinical nutrition and metabolic care 2007;10(6):693-7.
2007: Elena Korsheninnikova; P J Voshol; Bart Baan; Gerard C M van der Zon; L M Havekes; J A Romijn; J Antonie Maassen; D Margriet Ouwens
Dynamics of insulin signalling in liver during hyperinsulinemic euglycaemic clamp conditions in vivo and the effects of high-fat feeding in male mice.
Archives of physiology and biochemistry 2007;113(4-5):173-85.
2007: D Margriet Ouwens; Michaela Diamant; Mariann Fodor; D D J Habets; Maurice Pelsers; Mohammed El Hasnaoui; Zhi-Chao Dang; Charissa E van den Brom; Ronald Vlasblom; A Rietdijk; Christa Boer; Susan L M Coort; Jan F C Glatz; Joost J F P Luiken
Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification.
Diabetologia 2007;50(9):1938-48.
2007: Anne-Sophie de Preux; Katinka Goosen; Weixian Zhang; Anders A F Sima; Hitoshi Shimano; D Margriet Ouwens; Michaela Diamant; Jan-Luuk Hillebrands; Jan Rozing; Greg Lemke; Jacques Beckmann; August B Smit; Mark H G Verheijen; Roman Chrast
SREBP-1c expression in Schwann cells is affected by diabetes and nutritional status.
Molecular and cellular neurosciences 2007;35(4):525-34.
2007: D Margriet Ouwens; Michaela Diamant
Myocardial insulin action and the contribution of insulin resistance to the pathogenesis of diabetic cardiomyopathy.
Archives of physiology and biochemistry 2007;113(2):76-86.
2007: Jolita Ciapaite; Stephan J L Bakker; Gerco Van Eikenhorst; Marijke J Wagner; Tom Teerlink; Casper G Schalkwijk; Mariann Fodor; D Margriet Ouwens; Michaela Diamant; Robert J Heine; Hans V Westerhoff; Klaas Krab
Functioning of oxidative phosphorylation in liver mitochondria of high-fat diet fed rats.
Biochimica et biophysica acta 2007;1772(3):307-16.
2006: Emmani B M Nascimento; Mariann Fodor; Gerard C M van der Zon; Ingrid M Jazet; A Edo Meinders; Peter J Voshol; Ronald Vlasblom; Bart Baan; Jürgen Eckel; J Antonie Maassen; Michaela Diamant; D Margriet Ouwens
Insulin-mediated phosphorylation of the proline-rich Akt substrate PRAS40 is impaired in insulin target tissues of high-fat diet-fed rats.
Diabetes 2006;55(12):3221-8.
2006: Jan F C Glatz; Arend Bonen; D Margriet Ouwens; Joost J F P Luiken
Regulation of sarcolemmal transport of substrates in the healthy and diseased heart.
Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2006;20(6):471-6.
2006: Elena Korsheninnikova; Gerard C M van der Zon; Peter J Voshol; G M Janssen; Louis M Havekes; Aldo Grefhorst; Folkert Kuipers; Dirk-Jan Reijngoud; Johannes A Romijn; D Margriet Ouwens; J Antonie Maassen
Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice.
Diabetologia 2006;49(12):3049-57.
2006: Marion A M den Boer; Peter J Voshol; Janny P Schröder-van der Elst; Elena Korsheninnikova; D Margriet Ouwens; Folkert Kuipers; Louis M Havekes; Johannes A Romijn
Endogenous interleukin-10 protects against hepatic steatosis but does not improve insulin sensitivity during high-fat feeding in mice.
Endocrinology 2006;147(10):4553-8.
2006: Bart Baan; Hans van Dam; Gerard C M van der Zon; J Antonie Maassen; D Margriet Ouwens
The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2.
Molecular endocrinology (Baltimore, Md.) 2006;20(8):1786-95.
2005: Ingrid M Jazet; D Margriet Ouwens; Gert Schaart; Hanno Pijl; Hans Keizer; J Antonie Maassen; A Edo Meinders
Effect of a 2-day very low-energy diet on skeletal muscle insulin sensitivity in obese type 2 diabetic patients on insulin therapy.
Metabolism: clinical and experimental 2005;54(12):1669-78.
2005: Aldo Grefhorst; Jildou Hoekstra; Terry G J Derks; D Margriet Ouwens; Julius F W Baller; Rick Havinga; Louis M Havekes; Johannes A Romijn; Folkert Kuipers
Acute hepatic steatosis in mice by blocking beta-oxidation does not reduce insulin sensitivity of very-low-density lipoprotein production.
American journal of physiology. Gastrointestinal and liver physiology 2005;289(3):G592-8.
2005: D Margriet Ouwens; Christa Boer; Mariann Fodor; P de Galan; Robert J Heine; J Antonie Maassen; Michaela Diamant
Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats.
Diabetologia 2005;48(6):1229-37.
2003: Jeltje R Goudriaan; Vivian E H Dahlmans; Bas Teusink; D Margriet Ouwens; Maria Febbraio; J Antonie Maassen; Johannes A Romijn; Louis M Havekes; Peter J Voshol
CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice.
Journal of lipid research 2003;44(12):2270-7.
2003: Merlijn Bazuine; D Margriet Ouwens; Daan S Gomes de Mesquita; J Antonie Maassen
Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity.
European journal of biochemistry / FEBS 2003;270(19):3891-903.
2003: Peter J Voshol; Guenter Haemmerle; D Margriet Ouwens; Robert Zimmermann; Rudolf Zechner; Bas Teusink; J Antonie Maassen; Louis M Havekes; Johannes A Romijn
Increased hepatic insulin sensitivity together with decreased hepatic triglyceride stores in hormone-sensitive lipase-deficient mice.
Endocrinology 2003;144(8):3456-62.
2002: D Margriet Ouwens; Nancy D de Ruiter; Gerard C M van der Zon; Andrew P Carter; Jan Schouten; Corina van der Burgt; Klaas Kooistra; Johannes L Bos; J Antonie Maassen; Hans van Dam
Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
The EMBO journal 2002;21(14):3782-93.
2002: Gerdine A Kamp; D Margriet Ouwens; Cok M Hoogerbrugge; AH Zwinderman; J Antonie Maassen; Jan M Wit
Skin fibroblasts of children with idiopathic short stature show an increased mitogenic response to IGF-I and secrete more IGFBP-3.
Clinical endocrinology 2002;56(4):439-47.
2001: D Margriet Ouwens; Daan S Gomes de Mesquita; J Dekker; J Antonie Maassen
Hyperosmotic stress activates the insulin receptor in CHO cells.
Biochimica et biophysica acta 2001;1540(2):97-106.
2001: D Margriet Ouwens; Gerard C M van der Zon; J Antonie Maassen
Modulation of insulin-stimulated glycogen synthesis by Src Homology Phosphatase 2.
Molecular and cellular endocrinology 2001;175(1-2):131-40.
2001: A Kessler; I Uphues; D Margriet Ouwens; M Till; Jürgen Eckel
Diversification of cardiac insulin signaling involves the p85 alpha/beta subunits of phosphatidylinositol 3-kinase.
American journal of physiology. Endocrinology and metabolism 2001;280(1):E65-74.
2000: M Till; D Margriet Ouwens; A Kessler; Jürgen Eckel
Molecular mechanisms of contraction-regulated cardiac glucose transport.
The Biochemical journal 2000;346 Pt 3():841-7.
1997: DJ Withers; D Margriet Ouwens; BT Nave; Gerard C M van der Zon; C M Alarcon; Maria E Cardenas; J Heitman; J Antonie Maassen; Peter R Shepherd
Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells.
Biochemical and biophysical research communications 1997;241(3):704-9.