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Herman Overkleeft

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Gerbrand J van der Heden van Noort; Gijsbert A van der Marel; Herman S Overkleeft; Catherine H Schein; Dmitri V Filippov
A general synthetic method toward uridylylated picornavirus VPg proteins.
Hans A V Kistemaker; Herman S Overkleeft; Gerbrand J van der Heden van Noort; Gijsbert A van der Marel; Dmitri V Filippov
Stereoselective ribosylation of amino acids.
Riccardo Castelli; Herman S Overkleeft; Gijsbert A van der Marel; Jeroen D C Codée
2,2-Dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-Dimethyl-4-azido Butanoate: Two New Pivaloate-ester-like Protecting Groups.

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All Publications

2013: Gerbrand J van der Heden van Noort; Gijsbert A van der Marel; Herman S Overkleeft; Catherine H Schein; Dmitri V Filippov
A general synthetic method toward uridylylated picornavirus VPg proteins.
Journal of peptide science : an official publication of the European Peptide Society 2013;19(6):333-6.
2013: Hans A V Kistemaker; Herman S Overkleeft; Gerbrand J van der Heden van Noort; Gijsbert A van der Marel; Dmitri V Filippov
Stereoselective ribosylation of amino acids.
Organic letters 2013;15(9):2306-9.
2013: Riccardo Castelli; Herman S Overkleeft; Gijsbert A van der Marel; Jeroen D C Codée
2,2-Dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-Dimethyl-4-azido Butanoate: Two New Pivaloate-ester-like Protecting Groups.
Organic letters 2013;15(9):2270-3.
2013: Henrik Gold; Johanna E M Groener; Maria Joao Ferraz; Gabor E Linthorst; Johan Lugtenburg; Mina Mirzaian; Herman S Overkleeft; Johannes M Aerts; Jeroen D C Codée; Nick Dekker; Gijs A van der Marel; Ben J H M Poorthuis
Quantification of globotriaosylsphingosine in plasma and urine of fabry patients by stable isotope ultraperformance liquid chromatography-tandem mass spectrometry.
Clinical chemistry 2013;59(3):547-56.
2013: Paul P Geurink; Michael Groll; Annet E M Blom; Gerjan de Bruin; Christoph Driessen; Bogdan I Florea; Nerea Gallastegui; Anne C Mirabella; Elliot D Mock; Herman S Overkleeft; Wouter A van der Linden; Gijs A van der Marel; Mario van der Stelt; Mathias J Voges; Alexei F Kisselev
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites.
Journal of medicinal chemistry 2013;56(3):1262-75.
2012: Arwin J Brouwer; Bogdan I Florea; Nerea Gallastegui; Michael Groll; Anika Jonker; Johan Kemmink; Ethan Kuo; Nan Li; Herman S Overkleeft; Paul Werkhoven; Rob M J Liskamp
Peptido sulfonyl fluorides as new powerful proteasome inhibitors.
Journal of medicinal chemistry 2012;55(24):10995-1003.
2012: Wouter W Kallemeijn; Kah-Yee Li; André R A Marques; Roelof Ottenhoff; Johannes M F G Aerts; Jan Aten; Rolf G Boot; Jeroen D C Codée; Bogdan I Florea; Jianbing Jiang; Saskia Scheij; Hans van den Elst; Gijsbert A van der Marel; Cindy P A A van Roomen; Tineke M Voorn-Brouwer; Marthe T C Walvoort; Lianne I Willems; Martin D Witte; Herman S Overkleeft
Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo.
Angewandte Chemie (International ed. in English) 2012;51(50):12529-33.
2012: Jacob Gubbens; Marleen Janus; Herman S Overkleeft; Bogdan I Florea; Gilles P van Wezel
Identification of glucose kinase-dependent and -independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics.
Molecular microbiology 2012;86(6):1490-507.
2012: Jing Li; Nan Li; Mark Overhand; Herman S Overkleeft; Gijsbert A van der Marel; Bogdan I Florea; Paul P Geurink; Genevieve Girard; Gilles P van Wezel
Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach.
Organic & biomolecular chemistry 2012;10(43):8677-83.
2012: Santiago Barroso; Eva Casas-Arce; Riccardo Castelli; Jeroen D C Codée; Danny Geerdink; Herman S Overkleeft; Bjorn ter Horst; Gijsbert A van der Marel; Marc P Baggelaar; Adriaan J Minnaard
Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from Mycobacterium tuberculosis.
Angewandte Chemie (International ed. in English) 2012;51(47):11774-7.
2012: Matthijs van der Knaap; Gijsbert A van der Marel; Fatih Basalan; Henk J Busscher; Herman S Overkleeft; Henny C van de Mei; Mark Overhand
Synthesis and biological evaluation of gramicidin S-inspired cyclic mixed α/β-peptides.
Chemistry & biodiversity 2012;9(11):2494-506.
2012: Marthe T C Walvoort; Lianne I Willems; Martin D Witte; Gijsbert A van der Marel; Johannes M F G Aerts; Jeroen D C Codée; Wouter W Kallemeijn; Herman S Overkleeft
Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining β-glucosidase probes.
Chemical communications (Cambridge, England) 2012;48(84):10386-8.
2012: Varsha V Kapoerchan; Peter Keizer; Annemiek D Knijnenburg; Antonio Luis Llamas-Saiz; Roos H Mars-Groenendijk; Daan Noort; José M Otero; Herman S Overkleeft; Emile Spalburg; Gijs A van der Marel; Mark van Raaij; Albert J de Neeling; Mark Overhand
'Inverted' analogs of the antibiotic gramicidin S with an improved biological profile.
Bioorganic & medicinal chemistry 2012;20(20):6059-62.
2012: Gerbrand J van der Heden van Noort; Gijsbert A van der Marel; Pieter van Delft; Nico J Meeuwenoord; Herman S Overkleeft; Dmitri V Filippov
Fully automated sequential solid phase approach towards viral RNA-nucleopeptides.
Chemical communications (Cambridge, England) 2012;48(65):8093-5.
2012: Kjeld G H Janssen; Jiajie Li; Herman S Overkleeft; Niels R Tas; Richard J B H N van den Berg; Heiko J van der Linden; Paul Vulto; Jan C T Eijkel; Hanh T Hoang; Thomas Hankemeier
Limits of miniaturization: assessing ITP performance in sub-micron and nanochannels.
Lab on a chip 2012;12(16):2888-93.
2012: W F J Hogendorf; johannes huebner; Andrea Kropec; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov; Jeroen D C Codée
Light fluorous synthesis of glucosylated glycerol teichoic acids.
Carbohydrate research 2012;356():142-51.
2012: A E Christina; Jeroen D C Codée; F de Bordes; Herman S Overkleeft; W A Spruit; V M Blas Ferrando; Gijsbert A van der Marel
Multigram-scale synthesis of an orthogonally protected 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (AAT) building block.
Carbohydrate research 2012;356():282-7.
2012: Lianne I Willems; Bogdan I Florea; Nan Li; Mark Ruben; Gijsbert A van der Marel; Herman S Overkleeft
Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities.
Angewandte Chemie (International ed. in English) 2012;51(18):4431-4.
2012: Marthe T C Walvoort; Lenz Kröck; Herman S Overkleeft; Obadiah J Plante; Peter H Seeberger; Hans van den Elst; Gijsbert A van der Marel; Jeroen D C Codée
Automated solid-phase synthesis of β-mannuronic acid alginates.
Angewandte Chemie (International ed. in English) 2012;51(18):4393-6.
2012: Kerstin H Richau; Kurt Stüber; Martijn Verdoes; Matthew Bogyo; Tom Colby; Farnusch Kaschani; Sherry Niessen; Herman S Overkleeft; Twinkal C Pansuriya; Renier A L Van der Hoorn
Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.
Plant physiology 2012;158(4):1583-99.
2012: Nan Li; Herman S Overkleeft; Bogdan I Florea
Activity-based protein profiling: an enabling technology in chemical biology research.
Current opinion in chemical biology 2012;16(1-2):227-33.
2012: Alphert E Christina; Jasper Dinkelaar; Herman S Overkleeft; Daan van der Es; Gijsbert A van der Marel; Jeroen D C Codée
β-Rhamnosides from 6-thio mannosides.
Chemical communications (Cambridge, England) 2012;48(21):2686-8.
2012: Wouter F J Hogendorf; Lucien N Lameijer; Herman S Overkleeft; Thomas J M Beenakker; Jeroen D C Codée; Dmitri V Filippov; Gijsbert A van der Marel
Fluorous linker facilitated synthesis of teichoic acid fragments.
Organic letters 2012;14(3):848-51.
2012: Alexei F Kisselev; Wouter A van der Linden; Herman S Overkleeft
Proteasome inhibitors: an expanding army attacking a unique target.
Chemistry & biology 2012;19(1):99-115.
2012: Wouter A van der Linden; Gijsbert A van der Marel; Martijn Verdoes; Mark Ruben; Gerardus Josephus Boons; Bogdan I Florea; Jun Guo; Sascha Hoogendoorn; Nan Li; Herman S Overkleeft
Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study.
Bioorganic & medicinal chemistry 2012;20(2):662-6.
2012: Wouter A van der Linden; Gijs A van der Marel; Lianne I Willems; Mark Ruben; Tamer B Shabaneh; Bogdan I Florea; Markus Kaiser; Alexei F Kisselev; Nan Li; Herman S Overkleeft
Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones.
Organic & biomolecular chemistry 2012;10(1):181-94.
2012: Elisa Lombardo; Roelof Ottenhoff; Herman S Overkleeft; Martin van Eijk; Gijs H van Puijvelde; Cindy P A A van Roomen; Arthur J Verhoeven; Johannes M F G Aerts; Jan Aten; Albert K Groen; Johan Kuiper; Florence Bietrix
Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.
PloS one 2012;7(10):e38520.
2012: Paul P Geurink; Laurette M Prely; Gijs A van der Marel; Rainer Bischoff; Herman S Overkleeft
Photoaffinity labeling in activity-based protein profiling.
Topics in current chemistry 2012;324():85-113.
2011: Sascha Hoogendoorn; Gijsbert A van der Marel; Lianne I Willems; Annet E M Blom; Herman S Overkleeft
Synthesis of pH-activatable red fluorescent BODIPY dyes with distinct functionalities.
Organic letters 2011;13(20):5656-9.
2011: Nick Dekker; Maria J Ferraz; Karen Ghauharali; Johanna E M Groener; Carla E M Hollak; Mario Maas; Pramod K Mistry; Herman S Overkleeft; Saskia Scheij; Dave Speijer; Anna Tylki-Szymanska; Mariëlle J Van Breemen; Laura van Dussen; Frits A Wijburg; Rolf G Boot; Johannes M Aerts
Elevated plasma glucosylsphingosine in Gaucher disease: relation to phenotype, storage cell markers, and therapeutic response.
Blood 2011;118(16):e118-27.
2011: Lianne I Willems; Wouter A van der Linden; Gijs A van der Marel; Bogdan I Florea; Sascha Hoogendoorn; Kah-Yee Li; Nan Li; Nora Liu; Herman S Overkleeft
Bioorthogonal chemistry: applications in activity-based protein profiling.
Accounts of chemical research 2011;44(9):718-29.
2011: Marthe T C Walvoort; Jeroen D C Codée; Gerrit Lodder; Gert-Jan Moggré; Herman S Overkleeft; Gijsbert A van der Marel
Stereoselective synthesis of 2,3-diamino-2,3-dideoxy-β-D-mannopyranosyl uronates.
The Journal of organic chemistry 2011;76(18):7301-15.
2011: Martin D Witte; Gijsbert A van der Marel; Johannes M F G Aerts; Herman S Overkleeft
Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology.
Organic & biomolecular chemistry 2011;9(17):5908-26.
2011: Sascha Hoogendoorn; Johan Kuiper; Bogdan I Florea; Kim L Habets; Solène Passemard; Gijsbert A van der Marel; Herman S Overkleeft
Targeted pH-dependent fluorescent activity-based cathepsin probes.
Chemical communications (Cambridge, England) 2011;47(33):9363-5.
2011: Henrik Gold; Stefan Munneke; Herman S Overkleeft; Johannes M F G Aerts; Jeroen D C Codée; Jasper Dinkelaar; Gijs A van der Marel
A practical synthesis of capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates.
Carbohydrate research 2011;346(12):1467-78.
2011: Wouter F J Hogendorf; Johannes Huebner; Andrea Kropec; Diana Laverde; Nico J Meeuwenoord; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov; Jeroen D C Codée
Automated solid phase synthesis of teichoic acids.
Chemical communications (Cambridge, England) 2011;47(31):8961-3.
2011: Marthe T C Walvoort; Jesse van Dijk; Jeroen D C Codée; Wilbert de Witte; Jasper Dinkelaar; Gerrit Lodder; Herman S Overkleeft; Gijsbert A van der Marel
Mannopyranosyl uronic acid donor reactivity.
Organic letters 2011;13(16):4360-3.
2011: Gerbrand J van der Heden van Noort; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov
Ribosylation of adenosine: an orthogonally protected building block for the synthesis of ADP-ribosyl oligomers.
Organic letters 2011;13(11):2920-3.
2011: Annemiek D Knijnenburg; Varsha V Kapoerchan; Gijsbert M Grotenbreg; Emile Spalburg; Albert J de Neeling; Roos H Mars-Groenendijk; Daan Noort; José M Otero; Antonio Luis Llamas-Saiz; Mark van Raaij; Bep Ravensbergen; Peter H Nibbering; Gijs A van der Marel; Herman S Overkleeft; Mark Overhand
Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives.
Bioorganic & medicinal chemistry 2011;19(11):3402-9.
2011: Johannes M F G Aerts; Josanne Cox-Brinkman; Nick Dekker; Henrik Gold; Johanna E M Groener; Carla E M Hollak; Maria Joao Ferraz; Wouter W Kallemeijn; Gertjan Kramer; Gabor E Linthorst; Herman S Overkleeft; B J H M Poorthuis; Saskia M Rombach; Mariëlle J Van Breemen; Gijs A van der Marel; Wouter Wegdam; Martin D Witte; Rolf G Boot
Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies.
Journal of inherited metabolic disease 2011;34(3):605-19.
2011: Anne C Mirabella; Alexandre A Pletnev; Sondra L Downey; Bogdan I Florea; Tamer B Shabaneh; Matthew Britton; Martijn Verdoes; Dmitri V Filippov; Herman S Overkleeft; Alexei F Kisselev
Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib.
Chemistry & biology 2011;18(5):608-18.
2011: Paul P Geurink; Bogdan I Florea; Herman S Overkleeft
Activity-based profiling of 2-oxoglutarate oxygenases.
Chemistry & biology 2011;18(5):557-9.
2011: Martin D Witte; Marthe T C Walvoort; Kah-Yee Li; Wouter W Kallemeijn; Wilma E Donker-Koopman; Rolf G Boot; Johannes M F G Aerts; Jeroen D C Codée; Gijsbert A van der Marel; Herman S Overkleeft
Activity-based profiling of retaining β-glucosidases: a comparative study.
Chembiochem : a European journal of chemical biology 2011;12(8):1263-9.
2011: Matthijs van der Knaap; Lianne T Lageveen; Henk J Busscher; Roos H Mars-Groenendijk; Daan Noort; José M Otero; Antonio Luis Llamas-Saiz; Mark van Raaij; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Evaluation of readily accessible azoles as mimics of the aromatic ring of D-phenylalanine in the turn region of gramicidin S.
ChemMedChem 2011;6(5):840-7.
2011: John T Chang; Maria L Ciocca; Ichiko Kinjyo; Vikram R Palanivel; Courtney E McClurkin; Caitlin S Dejong; Erin C Mooney; Jiyeon S Kim; Natalie C Steinel; Jane Oliaro; Catherine C Yin; Bogdan I Florea; Herman S Overkleeft; Leslie J Berg; Sarah M Russell; Gary A Koretzky; Martha S Jordan; Steven L Reiner
Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.
Immunity 2011;34(4):492-504.
2011: Annemiek D Knijnenburg; Adriaan W Tuin; Emile Spalburg; Albert J de Neeling; Roos H Mars-Groenendijk; Daan Noort; José M Otero; Antonio Luis Llamas-Saiz; Mark van Raaij; Gijs A van der Marel; Herman S Overkleeft; Mark Overhand
Exploring the conformational and biological versatility of β-turn-modified gramicidin S by using sugar amino acid homologues that vary in ring size.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(14):3995-4004.
2011: Alphert E Christina; Leendert J van den Bos; Herman S Overkleeft; Gijsbert A van der Marel; Jeroen D C Codée
Galacturonic acid lactones in the synthesis of all trisaccharide repeating units of the zwitterionic polysaccharide Sp1.
The Journal of organic chemistry 2011;76(6):1692-706.
2011: Nick Dekker; Tineke Voorn-Brouwer; Marri Verhoek; Tom Wennekes; Ravi S Narayan; Dave Speijer; Carla E M Hollak; Herman S Overkleeft; Rolf G Boot; Johannes M F G Aerts
The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation.
Blood cells, molecules & diseases 2011;46(1):19-26.
2011: Jérôme Clerc; Nan Li; Daniel Krahn; Michael Groll; André S Bachmann; Bogdan I Florea; Herman S Overkleeft; Markus Kaiser
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity.
Chemical communications (Cambridge, England) 2011;47(1):385-7.
2011: Johannes M Aerts; Jan Aten; Florence M Bietrix; Nora Bijl; Rolf G Boot; Nick Dekker; Albert K Groen; Johanna E M Groener; Mirjam Langeveld; Elisa Lombardo; Roelof Ottenhoff; Mireille Serlie; Marco van Eijk; Cindy van Roomen; Tom Wennekes; Herman S Overkleeft
Glycosphingolipids and insulin resistance.
Advances in experimental medicine and biology 2011;721():99-119.
2011: Jeroen D C Codée; Alphert E Christina; Marthe T C Walvoort; Herman S Overkleeft; Gijsbert A van der Marel
Uronic acids in oligosaccharide and glycoconjugate synthesis.
Topics in current chemistry 2011;301():253-89.
2011: Izabella Kolodziejek; Johana C Misas-Villamil; Farnusch Kaschani; Jérôme Clerc; Christian Gu; Daniel Krahn; Sherry Niessen; Martijn Verdoes; Lianne I Willems; Herman S Overkleeft; Markus Kaiser; Renier A L Van der Hoorn
Proteasome activity imaging and profiling characterizes bacterial effector syringolin A.
Plant physiology 2011;155(1):477-89.
2010: Paul P Geurink; Bogdan I Florea; Gijs A Van der Marel; Benedikt M Kessler; Herman S Overkleeft
Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates.
Chemical communications (Cambridge, England) 2010;46(47):9052-4.
2010: Mikael Altun; Henrike C Besche; Herman S Overkleeft; Rosanna Piccirillo; Mariola J Edelmann; Benedikt M Kessler; Alfred L Goldberg; Brun Ulfhake
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway.
The Journal of biological chemistry 2010;285(51):39597-608.
2010: Michael Screen; Matthew Britton; Sondra L Downey; Martijn Verdoes; Mathias J Voges; Annet E M Blom; Paul P Geurink; Martijn D P Risseeuw; Bogdan I Florea; Wouter A van der Linden; Alexandre A Pletnev; Herman S Overkleeft; Alexei F Kisselev
Nature of pharmacophore influences active site specificity of proteasome inhibitors.
The Journal of biological chemistry 2010;285(51):40125-34.
2010: Marthe T C Walvoort; Gerrit Lodder; Herman S Overkleeft; Jeroen D C Codée; Gijsbert A van der Marel
Mannosazide methyl uronate donors. Glycosylating properties and use in the construction of β-ManNAcA-containing oligosaccharides.
The Journal of organic chemistry 2010;75(23):7990-8002.
2010: Pieter van Delft; Nico J Meeuwenoord; Sascha Hoogendoorn; Jasper Dinkelaar; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov
Synthesis of oligoribonucleic acid conjugates using a cyclooctyne phosphoramidite.
Organic letters 2010;12(23):5486-9.
2010: Martin D Witte; Wouter W Kallemeijn; Jan Aten; Kah-Yee Li; Anneke Strijland; Wilma E Donker-Koopman; Adrianus M C H van den Nieuwendijk; Boris Bleijlevens; Gertjan Kramer; Bogdan I Florea; Berend Hooibrink; Carla E M Hollak; Roelof Ottenhoff; Rolf G Boot; Gijsbert A van der Marel; Herman S Overkleeft; Johannes M F G Aerts
Ultrasensitive in situ visualization of active glucocerebrosidase molecules.
Nature chemical biology 2010;6(12):907-13.
2010: Annemiek D Knijnenburg; Varsha V Kapoerchan; Emile Spalburg; Albert J de Neeling; Roos H Mars-Groenendijk; Daan Noort; Gijs A van der Marel; Herman S Overkleeft; Mark Overhand
Tuning hydrophobicity of highly cationic tetradecameric Gramicidin S analogues using adamantane amino acids.
Bioorganic & medicinal chemistry 2010;18(23):8403-9.
2010: Varsha V Kapoerchan; Annemiek D Knijnenburg; Miquel Niamat; Emile Spalburg; Albert J de Neeling; Peter H Nibbering; Roos H Mars-Groenendijk; Daan Noort; José M Otero; Antonio Luis Llamas-Saiz; Mark van Raaij; Gijs A van der Marel; Herman S Overkleeft; Mark Overhand
An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(40):12174-81.
2010: Martijn D P Risseeuw; Bogdan I Florea; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors.
Bioorganic chemistry 2010;38(5):202-9.
2010: Paul P Geurink; Bogdan I Florea; Nan Li; Martin D Witte; Joeri Verasdonck; Chi-Lin Kuo; Gijs A van der Marel; Herman S Overkleeft
A cleavable linker based on the levulinoyl ester for activity-based protein profiling.
Angewandte Chemie (International ed. in English) 2010;49(38):6802-5.
2010: Adrianus M C H van den Nieuwendijk; Mark Ruben; Sander E Engelsma; Martijn D P Risseeuw; Richard J B H N van den Berg; Rolf G Boot; Johannes M Aerts; Johannes Brussee; Gijs A van der Marel; Herman S Overkleeft
Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin.
Organic letters 2010;12(17):3957-9.
2010: Bogdan I Florea; Martijn Verdoes; Nan Li; Wouter A van der Linden; Paul P Geurink; Hans van den Elst; Tanja Hofmann; Arnoud de Ru; Peter A van Veelen; Keiji Tanaka; Katsuhiro Sasaki; Shigeo Murata; Hans den Dulk; Jaap Brouwer; Ferry A Ossendorp; Alexei F Kisselev; Herman S Overkleeft
Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t.
Chemistry & biology 2010;17(8):795-801.
2010: Gerbrand J van der Heden van Noort; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov
Synthesis of nucleotidylated poliovirus VPg proteins.
The Journal of organic chemistry 2010;75(16):5733-6.
2010: Lianne I Willems; Martijn Verdoes; Bogdan I Florea; Gijsbert A van der Marel; Herman S Overkleeft
Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation.
Chembiochem : a European journal of chemical biology 2010;11(12):1769-81.
2010: Marthe T C Walvoort; Jasper Dinkelaar; Leendert J van den Bos; Gerrit Lodder; Herman S Overkleeft; Jeroen D C Codée; Gijsbert A van der Marel
The impact of oxacarbenium ion conformers on the stereochemical outcome of glycosylations.
Carbohydrate research 2010;345(10):1252-63.
2010: Martijn Verdoes; Lianne I Willems; Wouter A van der Linden; Boudewijn A Duivenvoorden; Gijsbert A van der Marel; Bogdan I Florea; Alexei F Kisselev; Herman S Overkleeft
A panel of subunit-selective activity-based proteasome probes.
Organic & biomolecular chemistry 2010;8(12):2719-27.
2010: Wouter F J Hogendorf; Leendert J Van den Bos; Herman S Overkleeft; Jeroen D C Codée; Gijsbert A Van der Marel
Synthesis of an alpha-kojibiosyl substituted glycerol teichoic acid hexamer.
Bioorganic & medicinal chemistry 2010;18(11):3668-78.
2010: Wouter A van der Linden; Paul P Geurink; Chris Oskam; Gijsbert A van der Marel; Bogdan I Florea; Herman S Overkleeft
Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors.
Organic & biomolecular chemistry 2010;8(8):1885-93.
2010: Kimberly M Bonger; Varsha V Kapoerchan; Gijsbert M Grotenbreg; Chris J van Koppen; C Marco Timmers; Gijsbert A van der Marel; Herman S Overkleeft
Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands.
Organic & biomolecular chemistry 2010;8(8):1881-4.
2010: Gerbrand J van der Heden van Noort; Maarten G van der Horst; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov
Synthesis of mono-ADP-ribosylated oligopeptides using ribosylated amino acid building blocks.
Journal of the American Chemical Society 2010;132(14):5236-40.
2010: Varsha V Kapoerchan; Emile Spalburg; Albert J de Neeling; Roos H Mars-Groenendijk; Daan Noort; José M Otero; Patricia Ferraces-Casais; Antonio Luis Llamas-Saiz; Mark van Raaij; Joop van Doorn; Gijs A van der Marel; Herman S Overkleeft; Mark Overhand
Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAs) as turn mimetics.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(14):4259-65.
2010: Paul P Geurink; Nora Liu; Michiel P Spaans; Sondra L Downey; Adrianus M C H van den Nieuwendijk; Gijsbert A van der Marel; Alexei F Kisselev; Bogdan I Florea; Herman S Overkleeft
Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites.
Journal of medicinal chemistry 2010;53(5):2319-23.
2010: Varsha V Kapoerchan; Martina Wiesner; Ulrik Hillaert; Jan W Drijfhout; Mark Overhand; Philippe Alard; Gijs A van der Marel; Herman S Overkleeft; Frits Koning
Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule.
Molecular immunology 2010;47(5):1091-7.
2010: Tom Wennekes; Alfred J Meijer; Albert K Groen; Rolf G Boot; Johanna E M Groener; Martin van Eijk; Roelof Ottenhoff; Nora Bijl; Karen Ghauharali; Hang Song; Tom J O'Shea; Hanlan Liu; Nelson Yew; Diane Copeland; Richard J B H N van den Berg; Gijsbert A van der Marel; Herman S Overkleeft; Johannes M Aerts
Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation.
Journal of medicinal chemistry 2010;53(2):689-98.
2010: Monique van Scherpenzeel; Richard J B H N van den Berg; Wilma E Donker-Koopman; Rob M J Liskamp; Johannes M F G Aerts; Herman S Overkleeft; Roland J Pieters
Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase.
Bioorganic & medicinal chemistry 2010;18(1):267-73.
2009: Matthew Britton; Marcella M Lucas; Sondra L Downey; Michael Screen; Alexandre A Pletnev; Martijn Verdoes; Robert A Tokhunts; Omar Amir; Ayrton L Goddard; Philip M Pelphrey; Dennis L Wright; Herman S Overkleeft; Alexei F Kisselev
Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites.
Chemistry & biology 2009;16(12):1278-89.
2009: Kimberly M Bonger; Sascha Hoogendoorn; Chris J van Koppen; Cornelis M Timmers; Herman S Overkleeft; Gijsbert A van der Marel
Synthesis and pharmacological evaluation of dimeric follicle-stimulating hormone receptor antagonists.
ChemMedChem 2009;4(12):2098-102.
2009: Annemiek D Knijnenburg; Emile Spalburg; Albert J de Neeling; Roos H Mars-Groenendijk; Daan Noort; Gijsbert M Grotenbreg; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity.
ChemMedChem 2009;4(12):1976-9.
2009: Martijn D P Risseeuw; Richard J B H N van den Berg; Wilma E Donker-Koopman; Gijs A van der Marel; Johannes M F G Aerts; Mark Overhand; Herman S Overkleeft
Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(23):6600-3.
2009: Jérôme Clerc; Bogdan I Florea; Marianne Kraus; Michael Groll; Robert Huber; André S Bachmann; Robert Dudler; Christoph Driessen; Herman S Overkleeft; Markus Kaiser
Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines.
Chembiochem : a European journal of chemical biology 2009;10(16):2638-43.
2009: Marthe T C Walvoort; Gerrit Lodder; Jaroslaw Mazurek; Herman S Overkleeft; Jeroen D C Codée; Gijsbert A van der Marel
Equatorial anomeric triflates from mannuronic acid esters.
Journal of the American Chemical Society 2009;131(34):12080-1.
2009: Martin D Witte; Bogdan I Florea; Martijn Verdoes; Oloruntosin Adeyanju; Gijs A Van der Marel; Herman S Overkleeft
O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes.
Journal of the American Chemical Society 2009;131(34):12064-5.
2009: Adriaan W Tuin; Gijsbert M Grotenbreg; Emile Spalburg; Albert J de Neeling; Roos H Mars-Groenendijk; Gijsbert A van der Marel; Daan Noort; Herman S Overkleeft; Mark Overhand
Structural and biological evaluation of some loloatin C analogues.
Bioorganic & medicinal chemistry 2009;17(17):6233-40.
2009: Matthijs van der Knaap; Eefje Engels; Henk J Busscher; José M Otero; Antonio Luis Llamas-Saiz; Mark van Raaij; Roos H Mars-Groenendijk; Daan Noort; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.
Bioorganic & medicinal chemistry 2009;17(17):6318-28.
2009: Jasper Dinkelaar; Ana Rae de Jong; Robert van Meer; Mark Somers; Gerrit Lodder; Herman S Overkleeft; Jeroen D C Codée; Gijsbert A van der Marel
Stereodirecting effect of the pyranosyl C-5 substituent in glycosylation reactions.
The Journal of organic chemistry 2009;74(14):4982-91.
2009: Kimberly M Bonger; Richard J B H N van den Berg; Annemiek D Knijnenburg; Laura Heitman; Chris J van Koppen; Cornelis M Timmers; Herman S Overkleeft; Gijsbert A van der Marel
Discovery of selective luteinizing hormone receptor agonists using the bivalent ligand method.
ChemMedChem 2009;4(7):1189-95.
2009: Jasper Dinkelaar; Henrik Gold; Herman S Overkleeft; Jeroen D C Codée; Gijsbert A van der Marel
Synthesis of hyaluronic acid oligomers using chemoselective and one-pot strategies.
The Journal of organic chemistry 2009;74(11):4208-16.
2009: T Rückrich; Marianne Kraus; Jeannette Gogel; Alexander Beck; Huib Ovaa; M Verdoes; Herman S Overkleeft; Hubert Kalbacher; Christoph Driessen
Characterization of the ubiquitin-proteasome system in bortezomib-adapted cells.
Leukemia 2009;23(6):1098-105.
2009: Jimmy J Weterings; Selina Khan; Gerbrand J van der Heden van Noort; Cornelis J M Melief; Herman S Overkleeft; Sjoerd H van der burg; Ferry Ossendorp; Gijsbert A van der Marel; Dmitri V Filippov
2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.
Bioorganic & medicinal chemistry letters 2009;19(8):2249-51.
2009: Selina Khan; Jimmy J Weterings; Cedrik Michael Britten; Ana R de Jong; Dirk Graafland; Cornelis J M Melief; Sjoerd H van der burg; Gijs van der Marel; Herman S Overkleeft; Dmitri V Filippov; Ferry Ossendorp
Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells.
Molecular immunology 2009;46(6):1084-91.
2009: Sandra van Heiningen; Ilze Bot; Jan H von der Thüsen; Michiel A Leeuwenburgh; Herman S Overkleeft; A O Kraaijeveld; Rick Dorland; Peter J Van Santbrink; S H van Heiningen; M M Westra; Petri Kovanen; J Wouter Jukema; Ernst E van der Wall; Theo Van berkel; G P Shi; Erik A L Biessen
Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(2):188-94.
2009: Martin D Witte; Danielle Horst; Emmanuel J H J Wiertz; Gijsbert A van der Marel; Herman S Overkleeft
Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library.
The Journal of organic chemistry 2009;74(2):605-16.
2009: Jeroen D C Codée; Leendert J van den Bos; Ana-Rae de Jong; Jasper Dinkelaar; Gerrit Lodder; Herman S Overkleeft; Gijsbert A van der Marel
The stereodirecting effect of the glycosyl C5-carboxylate ester: stereoselective synthesis of beta-mannuronic acid alginates.
The Journal of organic chemistry 2009;74(1):38-47.
2009: Tom Wennekes; Richard J B H N van den Berg; Rolf G Boot; Gijsbert A van der Marel; Herman S Overkleeft; Johannes M F G Aerts
Glycosphingolipids--nature, function, and pharmacological modulation.
Angewandte Chemie (International ed. in English) 2009;48(47):8848-69.
2009: Jimmy J Weterings; Selina Khan; Jan Wouter Drijfhout; Ferry Ossendorp; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov
Synthesis of modified and hybrid protein derived biopolymers.
Advances in experimental medicine and biology 2009;611():141-2.
2009: Martin van Eijk; Jan Aten; Nora Bijl; Roelof Ottenhoff; Cindy P A A van Roomen; Peter F Dubbelhuis; Ingar Seeman; Karen Ghauharali-van der Vlugt; Herman S Overkleeft; Cynthia Arbeeny; Albert K Groen; Johannes M F G Aerts
Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation.
PloS one 2009;4(3):e4723.
2009: Ulrik Hillaert; Martijn Verdoes; Bogdan I Florea; Athanasios Saragliadis; Anastasios Saragliadis; Kim L L Habets; Johan Kuiper; Serge Van Calenbergh; Ferry Ossendorp; Gijsbert A van der Marel; Christoph Driessen; Herman S Overkleeft
Receptor-mediated targeting of cathepsins in professional antigen presenting cells.
Angewandte Chemie (International ed. in English) 2009;48(9):1629-32.
2009: Farnusch Kaschani; Steven H L Verhelst; Paul F van Swieten; Martijn Verdoes; Chung-Sing Wong; Zheming Wang; Markus Kaiser; Herman S Overkleeft; Matthew Bogyo; Renier A L Van der Hoorn
Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'.
The Plant journal : for cell and molecular biology 2009;57(2):373-85.
2008: Henrik Gold; Pieter van Delft; Nico Meeuwenoord; Jeroen D C Codée; Dmitri V Filippov; Gerrit Eggink; Herman S Overkleeft; Gijs A van der Marel
Synthesis of sugar nucleotides by application of phosphoramidites.
The Journal of organic chemistry 2008;73(23):9458-60.
2008: Gerbrand J van der Heden van Noort; Carlo P Verhagen; Maarten G van der Horst; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov
A versatile one-pot procedure to phosphate monoesters and pyrophosphates using di(p-methoxybenzyl)-N,N-diisopropylphosphoramidite.
Organic letters 2008;10(20):4461-4.
2008: Tobias Kessler; Michael Reich; Gerhard Jahn; Eva Tolosa; Alexander Beck; Hubert Kalbacher; Herman S Overkleeft; Susanne Schempp; Christoph Driessen
Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levels.
The Journal of general virology 2008;89(Pt 10):2427-36.
2008: Nicolas Fissolo; Marianne Kraus; Michael Reich; Miriam Ayturan; Herman S Overkleeft; Christoph Driessen; Robert Weissert
Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation.
European journal of immunology 2008;38(9):2401-11.
2008: Martijn Verdoes; Bogdan I Florea; Ulrik Hillaert; Lianne I Willems; Wouter A van der Linden; Myra Sae-Heng; Dmitri V Filippov; Alexei F Kisselev; Gijsbert A van der Marel; Herman S Overkleeft
Azido-BODIPY acid reveals quantitative Staudinger-Bertozzi ligation in two-step activity-based proteasome profiling.
Chembiochem : a European journal of chemical biology 2008;9(11):1735-8.
2008: Paul Geurink; Theo Klein; Michiel Leeuwenburgh; Gijs van der Marel; Henk Kauffman; Rainer Bischoff; Herman S Overkleeft
A peptide hydroxamate library for enrichment of metalloproteinases: towards an affinity-based metalloproteinase profiling protocol.
Organic & biomolecular chemistry 2008;6(7):1244-50.
2008: Kimberly M Bonger; Richard J B H N van den Berg; Annemiek D Knijnenburg; Laura Heitman; Adriaan P IJzerman; Julia Oosterom; Cornelis M Timmers; Herman S Overkleeft; Gijsbert A van der Marel
Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core.
Bioorganic & medicinal chemistry 2008;16(7):3744-58.
2008: Varsha V Kapoerchan; Martina Wiesner; Mark Overhand; Gijs A van der Marel; Frits Koning; Herman S Overkleeft
Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with celiac disease.
Bioorganic & medicinal chemistry 2008;16(4):2053-62.
2008: Anup M Jawalekar; Nico Meeuwenoord; J Sjef G O Cremers; Herman S Overkleeft; Gijs A van der Marel; Floris P J T Rutjes; Floris L van Delft
Conjugation of nucleosides and oligonucleotides by [3+2] cycloaddition.
The Journal of organic chemistry 2008;73(1):287-90.
2008: Jasper Dinkelaar; Leendert J van den Bos; Wouter F J Hogendorf; Gerrit Lodder; Herman S Overkleeft; Jeroen D C Codée; Gijsbert A van der Marel
Stereoselective synthesis of L-guluronic acid alginates.
Chemistry (Weinheim an der Bergstrasse, Germany) 2008;14(30):9400-11.
2007: Coenraad Kuijl; Nigel D L Savage; Marije Marsman; Adriaan W Tuin; Lennert Janssen; David A Egan; Mirjam Ketema; Rian van den Nieuwendijk; Susan J F van den Eeden; Annemieke Geluk; Alex Poot; Gijsbert A van der Marel; Roderick L Beijersbergen; Herman S Overkleeft; Tom H M Ottenhoff; Jacques Neefjes
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1.
Nature 2007;450(7170):725-30.
2007: Martin D Witte; Carlos V Descals; Sebastiaan V P de Lavoir; Bogdan I Florea; Gijsbert A van der Marel; Herman S Overkleeft
Bodipy-VAD-Fmk, a useful tool to study yeast peptide N-glycanase activity.
Organic & biomolecular chemistry 2007;5(22):3690-7.
2007: Martijn Verdoes; Ulrik Hillaert; Bogdan I Florea; Myra Sae-Heng; Martijn D P Risseeuw; Dmitri V Filippov; Gijsbert A van der Marel; Herman S Overkleeft
Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes.
Bioorganic & medicinal chemistry letters 2007;17(22):6169-71.
2007: Martijn D P Risseeuw; Jaroslaw Mazurek; Arjan van Langenvelde; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Synthesis of alkylated sugar amino acids: conformationally restricted L-Xaa-L-Ser/Thr mimics.
Organic & biomolecular chemistry 2007;5(14):2311-4.
2007: Jasper Dinkelaar; Jeroen D C Codée; Leendert J van den Bos; Herman S Overkleeft; Gijsbert A van der Marel
Synthesis of hyaluronic acid oligomers using Ph2SO/Tf2O-mediated glycosylations.
The Journal of organic chemistry 2007;72(15):5737-42.
2007: Selina Khan; Martijn Bijker; Jimmy J Weterings; Hans J Tanke; Gosse J Adema; Thorbald van Hall; Jan Wouter Drijfhout; Cornelis J M Melief; Herman S Overkleeft; Gijsbert A van der Marel; Dmitri V Filippov; Sjoerd H van der burg; Ferry Ossendorp
Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.
The Journal of biological chemistry 2007;282(29):21145-59.
2007: Kimberly M Bonger; Richard J B H N van den Berg; Laura Heitman; Adriaan P IJzerman; Julia Oosterom; Cornelis M Timmers; Herman S Overkleeft; Gijsbert A van der Marel
Synthesis and evaluation of homo-bivalent GnRHR ligands.
Bioorganic & medicinal chemistry 2007;15(14):4841-56.
2007: Paul F van Swieten; Emlyn Samuel; Rosa Orient Hernández; Adrianus M C H van den Nieuwendijk; Michiel A Leeuwenburgh; Gijsbert A van der Marel; Benedikt M Kessler; Herman S Overkleeft; Alexei F Kisselev
A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome.
Bioorganic & medicinal chemistry letters 2007;17(12):3402-5.
2007: Anton P Bussink; Paul F van Swieten; Karen Ghauharali; Saskia Scheij; Martin van Eijk; Tom Wennekes; Gijsbert A van der Marel; Rolf G Boot; johannes aerts; Herman S Overkleeft
N-azidoacetylmannosamine-mediated chemical tagging of gangliosides.
Journal of lipid research 2007;48(6):1417-21.
2007: Martijn Verdoes; Bogdan I Florea; Wouter A van der Linden; Didier Renou; Adrianus M C H van den Nieuwendijk; Gijsbert A van der Marel; Herman S Overkleeft
Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors.
Organic & biomolecular chemistry 2007;5(9):1416-26.
2007: Timo Burster; Alexander Beck; Simone Poeschel; Anita ØRen; Daniel Baechle; Michael Reich; Olaf Roetzschke; Kirsten Falk; Bernhard O Boehm; Sawsan Youssef; Hubert Kalbacher; Herman S Overkleeft; Eva Tolosa; Christoph Driessen
Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitro.
Immunology 2007;121(1):82-93.
2007: johannes aerts; Roelof Ottenhoff; Andrew S Powlson; Aldo Grefhorst; Martin van Eijk; Peter F Dubbelhuis; Jan Aten; Folkert Kuipers; Mireille J Serlie; Tom Wennekes; Jaswinder Sethi; Stephen O'Rahilly; Herman S Overkleeft
Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity.
Diabetes 2007;56(5):1341-9.
2007: Michael Reich; Paul F van Swieten; Vinod Sommandas; Marianne Kraus; Rainer Fischer; Ekkehard Weber; Hubert Kalbacher; Herman S Overkleeft; Christoph Driessen
Endocytosis targets exogenous material selectively to cathepsin S in live human dendritic cells, while cell-penetrating peptides mediate nonselective transport to cysteine cathepsins.
Journal of leukocyte biology 2007;81(4):990-1001.
2007: Remy E J N Litjens; Leendert J van den Bos; Jeroen D C Codée; Herman S Overkleeft; Gijsbert A van der Marel
The use of cyclic bifunctional protecting groups in oligosaccharide synthesis--an overview.
Carbohydrate research 2007;342(3-4):419-29.
2007: Tom Wennekes; Richard J B H N van den Berg; Wilma Donker; Gijsbert A van der Marel; Anneke Strijland; johannes aerts; Herman S Overkleeft
Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man.
The Journal of organic chemistry 2007;72(4):1088-97.
2007: Prashant Agrawal; Mathias W Hofmann; Nico J Meeuwenoord; Dmitri V Filippov; Holger Stalz; Frans B Hulsbergen; Dieter Langosch; Herman S Overkleeft; Huub de Groot
Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides.
Journal of peptide science : an official publication of the European Peptide Society 2007;13(2):75-80.
2007: Rolf G Boot; Marri Verhoek; Wilma Donker-Koopman; Anneke Strijland; Jan van Marle; Herman S Overkleeft; Tom Wennekes; johannes aerts
Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2.
The Journal of biological chemistry 2007;282(2):1305-12.
2007: Marianne Kraus; T Rückrich; Michael Reich; Jeannette Gogel; Alexander Beck; Winfried Kammer; Celia R Berkers; D Burg; Herman S Overkleeft; Huib Ovaa; Christoph Driessen
Activity patterns of proteasome subunits reflect bortezomib sensitivity of hematologic malignancies and are variable in primary human leukemia cells.
Leukemia 2007;21(1):84-92.
2006: Martijn Verdoes; Bogdan I Florea; Victoria Menendez-Benito; Christa Maynard; Martin D Witte; Wouter A van der Linden; Adrianus M C H van den Nieuwendijk; Tanja Hofmann; Celia R Berkers; Fijs W B van Leeuwen; Tom A M Groothuis; Michiel A Leeuwenburgh; Huib Ovaa; Jacques Neefjes; Dmitri V Filippov; Gijsbert A van der Marel; Nico P Dantuma; Herman S Overkleeft
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo.
Chemistry & biology 2006;13(11):1217-26.
2006: Leendert J van den Bos; Jasper Dinkelaar; Herman S Overkleeft; Gijsbert A van der Marel
Stereocontrolled synthesis of beta-D-mannuronic acid esters: synthesis of an alginate trisaccharide.
Journal of the American Chemical Society 2006;128(40):13066-7.
2006: Jasper Dinkelaar; Martin D Witte; Leendert J van den Bos; Herman S Overkleeft; Gijsbert A van der Marel
NIS/TFA: a general method for hydrolyzing thioglycosides.
Carbohydrate research 2006;341(10):1723-9.
2006: Adriaan W Tuin; Gregg Siegal; Gijsbert A van der Marel; Herman S Overkleeft; Dmitri V Filippov
Facile synthesis and application of uniformly 13C, 15N-labeled phosphotyrosine for ligand binding studies.
Bioorganic & medicinal chemistry letters 2006;16(14):3806-8.
2006: Haixiang Yu; Karen M Sliedregt-Bol; Herman S Overkleeft; Gijsbert A van der Marel; Theo Van berkel; Erik A L Biessen
Therapeutic potential of a synthetic peptide inhibitor of nuclear factor of activated T cells as antirestenotic agent.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1531-7.
2006: Jimmy J Weterings; Selina Khan; Gerbrand J van der Heden; Jan Wouter Drijfhout; Cornelis J M Melief; Herman S Overkleeft; Sjoerd H van der burg; Ferry Ossendorp; Gijsbert A van der Marel; Dmitri V Filippov
Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.
Bioorganic & medicinal chemistry letters 2006;16(12):3258-61.
2006: Gijsbert M Grotenbreg; Annelies E M Buizert; Antonio Luis Llamas-Saiz; Emile Spalburg; Peter A V van Hooft; Albert J de Neeling; Daan Noort; Mark van Raaij; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product.
Journal of the American Chemical Society 2006;128(23):7559-65.
2006: Michiel A Leeuwenburgh; Paul P Geurink; Theo Klein; Henk Kauffman; Gijsbert A van der Marel; Rainer Bischoff; Herman S Overkleeft
Solid-phase synthesis of succinylhydroxamate peptides: functionalized matrix metalloproteinase inhibitors.
Organic letters 2006;8(8):1705-8.
2006: Micha Slegt; Roel Gronheid; Dennis van der Vlugt; Masahito Ochiai; Tadashi Okuyama; Han Zuilhof; Herman S Overkleeft; Gerrit Lodder
Photochemical generation of six- and five-membered cyclic vinyl cations.
The Journal of organic chemistry 2006;71(6):2227-35.
2006: Richard J B H N van den Berg; Thomas J Boltje; Carlo P Verhagen; Remy E J N Litjens; Gijsbert A van der Marel; Herman S Overkleeft
An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine.
The Journal of organic chemistry 2006;71(2):836-9.
2006: Clara Comuzzi; Susanna Cogoi; Mark Overhand; Gijsbert A van der Marel; Herman S Overkleeft; Luigi E Xodo
Synthesis and biological evaluation of new pentaphyrin macrocycles for photodynamic therapy.
Journal of medicinal chemistry 2006;49(1):196-204.
2006: Martijn Verdoes; Celia R Berkers; Bogdan I Florea; Paul F van Swieten; Herman S Overkleeft; Huib Ovaa
Chemical proteomics profiling of proteasome activity.
Methods in molecular biology (Clifton, N.J.) 2006;328():51-69.
2005: Timo Burster; Alexander Beck; Eva Tolosa; Petra Schnorrer; Robert Weissert; Michael Reich; Marianne Kraus; Hubert Kalbacher; Hans-Ulrich Häring; Ekkehard Weber; Herman S Overkleeft; Christoph Driessen
Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):5940-9.
2005: Steven van Zutphen; Elizabeth A Stone; Sabine van Rijt; Marc S Robillard; Gijsbert A van der Marel; Herman S Overkleeft; Hans den Dulk; Jaap Brouwer; Jan Reedijk
Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods.
Journal of inorganic biochemistry 2005;99(10):2032-8.
2005: Farid El Oualid; Hans van den Elst; Ingrid M Leroy; Elsbet Pieterman; Louis H Cohen; Brigitte E A Burm; Herman S Overkleeft; Gijsbert A van der Marel; Mark Overhand
A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein:geranylgeranyl transferase-1.
Journal of combinatorial chemistry 2005;7(5):703-13.
2005: Jeroen D C Codée; Remy E J N Litjens; Leendert J van den Bos; Herman S Overkleeft; Gijsbert A van der Marel
Thioglycosides in sequential glycosylation strategies.
Chemical Society reviews 2005;34(9):769-82.
2005: Peter C de Visser; Peter A V van Hooft; Anne-Marij de Vries; Ad de Jong; Gijsbert A van der Marel; Herman S Overkleeft; Daan Noort
Biological evaluation of Tyr6 and Ser7 modified drosocin analogues.
Bioorganic & medicinal chemistry letters 2005;15(11):2902-5.
2005: Steven van Zutphen; Marianne Kraus; Christoph Driessen; Gijsbert A van der Marel; Herman S Overkleeft; Jan Reedijk
Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity.
Journal of inorganic biochemistry 2005;99(6):1384-9.
2005: Anne-Marie M van Roon; Begoña Aguilera; Francisco Cuenca; Alexandra Van Remoortere; Gijsbert A van der Marel; André M Deelder; Herman S Overkleeft; Cornelis H Hokke
Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides.
Bioorganic & medicinal chemistry 2005;13(10):3553-64.
2005: Leendert J van den Bos; Remy E J N Litjens; Richard J B H N van den Berg; Herman S Overkleeft; Gijsbert A van der Marel
Preparation of 1-thio uronic acid lactones and their use in oligosaccharide synthesis.
Organic letters 2005;7(10):2007-10.
2005: Jeroen D C Codée; Bas Stubba; Marialuisa Schiattarella; Herman S Overkleeft; Constant van Boeckel; Jacques H van Boom; Gijsbert A van der Marel
A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy.
Journal of the American Chemical Society 2005;127(11):3767-73.
2005: Farid El Oualid; Jayand Baktawar; Ingrid M Leroy; Hans van den Elst; Louis H Cohen; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Synthesis and biological evaluation of lipophilic Ca(1)a(2)L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1.
Bioorganic & medicinal chemistry 2005;13(5):1463-75.
2005: Anna Borodovsky; Huib Ovaa; Wim J N Meester; Emily Venanzi; Matthew Bogyo; Brian G Hekking; Hidde L Ploegh; Benedikt M Kessler; Herman S Overkleeft
Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases.
Chembiochem : a European journal of chemical biology 2005;6(2):287-91.
2005: Gijsbert M Grotenbreg; Martin D Witte; Peter A V van Hoof; Emile Spalburg; Philipp Reiss; Daan Noort; Albert J de Neeling; Ulrich Koert; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Synthesis and biological evaluation of gramicidin S dimers.
Organic & biomolecular chemistry 2005;3(2):233-8.
2005: Remy E J N Litjens; René den Heeten; Mattie S M Timmer; Herman S Overkleeft; Gijsbert A van der Marel
An expedient synthesis of the repeating unit of the acidic polysaccharide of the bacteriolytic complex of lysoamidase.
Chemistry (Weinheim an der Bergstrasse, Germany) 2005;11(3):1010-6.
2005: Paul F van Swieten; Michiel A Leeuwenburgh; Benedikt M Kessler; Herman S Overkleeft
Bioorthogonal organic chemistry in living cells: novel strategies for labeling biomolecules.
Organic & biomolecular chemistry 2005;3(1):20-7.
2004: Marij J P Welters; Dmitri V Filippov; Susan J F van den Eeden; Kees L M C Franken; Jan Nouta; Rob Valentijn; Gijsbert A van der Marel; Herman S Overkleeft; Grayson Lipford; Rienk Offringa; Cornelis J M Melief; Jacques H van Boom; Sjoerd H van der burg; Jan Wouter Drijfhout
Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model.
Vaccine 2004;23(3):305-11.
2004: Peter C de Visser; Cindy Govaerts; Peter A V van Hooft; Herman S Overkleeft; Ann Van Schepdael; Jos Hoogmartens
Liquid chromatography-mass spectrometry study towards the pH and temperature-induced N-acyl migration in polymyxin B.
Journal of chromatography. A 2004;1058(1-2):183-9.
2004: Gijsbert M Grotenbreg; Alphert E Christina; Annelies E M Buizert; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Synthesis and application of carbohydrate-derived morpholine amino acids.
The Journal of organic chemistry 2004;69(24):8331-9.
2004: Gijsbert M Grotenbreg; Martijn Kronemeijer; Mattie S M Timmer; Farid El Oualid; Renate M van Well; Martijn Verdoes; Emile Spalburg; Peter A V van Hooft; Albert J de Neeling; Daan Noort; Jacques H van Boom; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
A practical synthesis of gramicidin s and sugar amino Acid containing analogues.
The Journal of organic chemistry 2004;69(23):7851-9.
2004: Michael Raunkjaer; Farid El Oualid; Gijsbert A van der Marel; Herman S Overkleeft; Mark Overhand
Alkylated sugar amino acids: a new entry toward highly functionalized dipeptide isosters.
Organic letters 2004;6(18):3167-70.
2004: Richard J B H N van den Berg; Cornelius G N Korevaar; Herman S Overkleeft; Gijsbert A van der Marel; Jacques H van Boom
Effective, high-yielding, and stereospecific total synthesis of D-erythro-(2R,3S)-sphingosine from D-ribo-(2S,3S,4R)-phytosphingosine.
The Journal of organic chemistry 2004;69(17):5699-704.
2004: Reynier A Tromp; Stella S G E van Boom; C Marco Timmers; Steven van Zutphen; Gijsbert A van der Marel; Herman S Overkleeft; Jacques H van Boom; Jan Reedijk
The beta-glucuronyl-based prodrug strategy allows for its application on beta-glucuronyl-platinum conjugates.
Bioorganic & medicinal chemistry letters 2004;14(16):4273-6.
2004: Farid El Oualid; Brigitte E A Burm; Ingrid M Leroy; Louis H Cohen; Jacques H van Boom; Hans van den Elst; Herman S Overkleeft; Gijsbert A van der Marel; Mark Overhand
Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1.
Journal of medicinal chemistry 2004;47(16):3920-3.
2004: Leendert J van den Bos; Jeroen D C Codée; John C van der Toorn; Thomas J Boltje; Jacques H van Boom; Herman S Overkleeft; Gijsbert A van der Marel
Thioglycuronides: synthesis and application in the assembly of acidic oligosaccharides.
Organic letters 2004;6(13):2165-8.
2004: Paul F van Swieten; Rene Maehr; Adrianus M C H van den Nieuwendijk; Benedikt M Kessler; Michael Reich; Chung-Sing Wong; Hubert Kalbacher; Michiel A Leeuwenburgh; Christoph Driessen; Gijsbert A van der Marel; Hidde L Ploegh; Herman S Overkleeft
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases.
Bioorganic & medicinal chemistry letters 2004;14(12):3131-4.
2004: Peter A V van Hooft; Farid El Oualid; Herman S Overkleeft; Gijsbert A van der Marel; Jacques H van Boom; Michiel A Leeuwenburgh
Synthesis and elaboration of functionalised carbohydrate-derived spiroketals.
Organic & biomolecular chemistry 2004;2(9):1395-403.
2004: Alfred Lautwein; Marianne Kraus; Michael Reich; Timo Burster; Jens Brandenburg; Herman S Overkleeft; Gerold Schwarz; Winfried Kammer; Ekkehard Weber; Hubert Kalbacher; Alfred Nordheim; Christoph Driessen
Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner.
Journal of leukocyte biology 2004;75(5):844-55.
2004: Gijsbert M Grotenbreg; Mattie S M Timmer; Antonio Luis Llamas-Saiz; Martijn Verdoes; Gijsbert A van der Marel; Mark van Raaij; Herman S Overkleeft; Mark Overhand
An unusual reverse turn structure adopted by a furanoid sugar amino acid incorporated in gramicidin S.
Journal of the American Chemical Society 2004;126(11):3444-6.
2003: Steven H L Verhelst; Baltasar Paez Martinez; Mattie S M Timmer; Gerrit Lodder; Gijsbert A van der Marel; Herman S Overkleeft; Jacques H van Boom
A short route toward chiral, polyhydroxylated indolizidines and quinolizidines.
The Journal of organic chemistry 2003;68(25):9598-603.
2003: Leendert J van den Bos; Jeroen D C Codée; Jacques H van Boom; Herman S Overkleeft; Gijsbert A van der Marel
A novel strategy towards the synthesis of orthogonally functionalised 4-aminoglycosides.
Organic & biomolecular chemistry 2003;1(23):4160-5.
2003: Michiel A Leeuwenburgh; Gijsbert A van der Marel; Herman S Overkleeft
Olefin metathesis in glycobiology: new routes towards diverse neoglycoconjugates.
Current opinion in chemical biology 2003;7(6):757-65.
2003: Mattie S M Timmer; Martijn Verdoes; Leo A J M Sliedregt; Gijsbert A van der Marel; Jacques H van Boom; Herman S Overkleeft
The use of a mannitol-derived fused oxacycle as a combinatorial scaffold.
The Journal of organic chemistry 2003;68(24):9406-11.
2003: Christine Kocks; Rene Maehr; Herman S Overkleeft; Evelyn W Wang; Lackshmanan K Iyer; Ana-Maria Lennon-Dumenil; Hidde L Ploegh; Benedikt M Kessler
Functional proteomics of the active cysteine protease content in Drosophila S2 cells.
Molecular & cellular proteomics : MCP 2003;2(11):1188-97.
2003: Begoña Aguilera; Karen Ghauharali-van der Vlugt; Mariette T J Helmond; Jos M M Out; Wilma E Donker-Koopman; Johanna E M Groener; Rolf G Boot; G Herma Renkema; Gijsbert A van der Marel; Jacques H van Boom; Herman S Overkleeft; johannes aerts
Transglycosidase activity of chitotriosidase: improved enzymatic assay for the human macrophage chitinase.
The Journal of biological chemistry 2003;278(42):40911-6.
2003: Alexei F Kisselev; Margarita Garcia-Calvo; Herman S Overkleeft; Erin Peterson; Michael Pennington; Hidde L Ploegh; Nancy A Thornberry; Alfred L Goldberg
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites.
The Journal of biological chemistry 2003;278(38):35869-77.
2003: Huib Ovaa; Paul F van Swieten; Benedikt M Kessler; Michiel A Leeuwenburgh; Edda Fiebiger; Adrianus M C H van den Nieuwendijk; Paul J Galardy; Gijsbert A van der Marel; Hidde L Ploegh; Herman S Overkleeft
Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy.
Angewandte Chemie (International ed. in English) 2003;42(31):3626-9.
2003: Ae-Ran Kwon; Benedikt M Kessler; Herman S Overkleeft; David B McKay
Structure and reactivity of an asymmetric complex between HslV and I-domain deleted HslU, a prokaryotic homolog of the eukaryotic proteasome.
Journal of molecular biology 2003;330(2):185-95.
2003: Gijsbert M Grotenbreg; Emile Spalburg; Albert J de Neeling; Gijsbert A van der Marel; Herman S Overkleeft; Jacques H van Boom; Mark Overhand
Synthesis and biological evaluation of novel turn-modified gramicidin S analogues.
Bioorganic & medicinal chemistry 2003;11(13):2835-41.
2003: Peter C de Visser; N M A J Kriek; Peter A V van Hooft; Ann Van Schepdael; Dmitri V Filippov; Gijsbert A van der Marel; Herman S Overkleeft; Jacques H van Boom; Daan Noort
Solid-phase synthesis of polymyxin B1 and analogues via a safety-catch approach.
The journal of peptide research : official journal of the American Peptide Society 2003;61(6):298-306.
2003: Jeroen D C Codée; Leendert J van den Bos; Remy E J N Litjens; Herman S Overkleeft; Jacques H van Boom; Gijsbert A van der Marel
Sequential one-pot glycosylations using 1-hydroxyl and 1-thiodonors.
Organic letters 2003;5(11):1947-50.
2003: Heinz Wiendl; Alfred Lautwein; Meike Mitsdörffer; Sabine Krause; Stella Eugenie Autenrieth; Wolfgang Wienhold; Matthias Morgalla; Ekkehard Weber; Herman S Overkleeft; Hanns Lochmüller; Arthur Melms; Eva Tolosa; Christoph Driessen
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies.
Journal of neuroimmunology 2003;138(1-2):132-43.
2003: Jeroen D C Codée; Remy E J N Litjens; René den Heeten; Herman S Overkleeft; Jacques H van Boom; Gijsbert A van der Marel
Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides.
Organic letters 2003;5(9):1519-22.
2003: Benedikt Kessler; Xu Hong; Jelena Petrovic; Anna Borodovsky; Nico P Dantuma; Matthew Bogyo; Herman S Overkleeft; Hidde L Ploegh; Rickard Glas
Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production.
The Journal of biological chemistry 2003;278(12):10013-21.
2003: Steven van Zutphen; Marc S Robillard; Gijsbert A van der Marel; Herman S Overkleeft; Hans den Dulk; Jaap Brouwer; Jan Reedijk
Extending solid-phase methods in inorganic synthesis: the first dinuclear platinum complex synthesised via the solid phase.
Chemical communications (Cambridge, England) 2003;(5):634-5.
2003: Renate M van Well; Herman S Overkleeft; Gijsbert A van der Marel; Dan Bruss; Gaétan Thibault; Phillip G de Groot; Jacques H van Boom; Mark Overhand
Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors.
Bioorganic & medicinal chemistry letters 2003;13(3):331-4.
2003: Andrea Greiner; Alfred Lautwein; Herman S Overkleeft; Ekkehard Weber; Christoph Driessen
Activity and subcellular distribution of cathepsins in primary human monocytes.
Journal of leukocyte biology 2003;73(2):235-42.
2002: Alfred Lautwein; Timo Burster; Ana-Maria Lennon-Duménil; Herman S Overkleeft; Ekkehard Weber; Hubert Kalbacher; Christoph Driessen
Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells.
European journal of immunology 2002;32(12):3348-57.
2002: Ana-Maria Lennon-Duménil; Arnold H Bakker; Rene Maehr; Edda Fiebiger; Herman S Overkleeft; Mario Rosemblatt; Hidde L Ploegh; Cécile Lagaudrière-Gesbert
Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.
The Journal of experimental medicine 2002;196(4):529-40.
2002: Marcelo C Sousa; Benedikt M Kessler; Herman S Overkleeft; David B McKay
Crystal structure of HslUV complexed with a vinyl sulfone inhibitor: corroboration of a proposed mechanism of allosteric activation of HslV by HslU.
Journal of molecular biology 2002;318(3):779-85.
2001: Anna Borodovsky; Benedikt M Kessler; R Casagrande; Herman S Overkleeft; Keith Wilkinson; Hidde L Ploegh
A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14.
The EMBO journal 2001;20(18):5187-96.
2001: Benedikt M Kessler; Domenico Tortorella; Mikael Altun; Alexei F Kisselev; Edda Fiebiger; Brian Hekking; Hidde L Ploegh; Herman S Overkleeft
Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits.
Chemistry & biology 2001;8(9):913-29.
2001: Ana-Maria Lennon-Duménil; R A Roberts; K Valentijn; Christoph Driessen; Herman S Overkleeft; Ann H Erickson; Peter J Peters; E Bikoff; Hidde L Ploegh; P Wolf Bryant
The p41 isoform of invariant chain is a chaperone for cathepsin L.
The EMBO journal 2001;20(15):4055-64.
2001: Begoña Aguilera; L B Wolf; P Nieczypor; Floris P J T Rutjes; Herman S Overkleeft; Jan C M van Hest; Hans E Schoemaker; B Wang; J C Mol; A Fürstner; Mark Overhand; Gijsbert A van der Marel; Jacques H van Boom
Synthesis of diaminosuberic acid derivatives via ring-closing alkyne metathesis.
The Journal of organic chemistry 2001;66(10):3584-9.
1998: Herman S Overkleeft; G Herma Renkema; Jolanda M Neele; P Vianello; I O Hung; Anneke Strijland; Alida M van der Burg; Gerrit-Jan Koomen; U K Pandit; johannes aerts
Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase.
The Journal of biological chemistry 1998;273(41):26522-7.