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Willem Overwijk

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Luis M Vence; Chiyu Wang; Gladys Alvarado; Ryan E Anson; Roland Bassett; Agop Y Bedikian; Cara Benjamin; Richard Boyd; Jade Homsi; Wen-Jen Hwu; Kevin Kim; Krishna Komanduri; Gregory Lizee; Priscilla Miller; Willem W Overwijk; Nicholas E Papadopoulos; Himabindu Pappu; Sapna P Patel; Tejal A Patel; Laszlo Radvanyi; Patrick Hwu
Chemical castration of melanoma patients does not increase the frequency of tumor-specific CD4 and CD8 T cells after peptide vaccination.
Yared Hailemichael; Xue-Fei Huang; Patrick Hwu; Nina Jaffarzad; Chengwen Liu; Yanyan Lou; Wencai Ma; Miguel A Medina; Giovanni Nitti; Zhimin Dai; Richard E Davis; Stephanie M Dorta-Estremera; Nathaniel R Greeley; Weiyi Peng; Brian A Rabinovich; Kimberly Schluns; Zhiqiang Wang; Yang Ye; Willem W Overwijk
Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion.
Nitin Chakravarti; Patrick Hwu; Marcella M Johnson; Willem W Overwijk; Vijay G R Peddareddigari; Carla L Warneke; Victor G Prieto
Differential expression of the g-protein-coupled formyl Peptide receptor in melanoma associates with aggressive phenotype.

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2013: Luis M Vence; Chiyu Wang; Gladys Alvarado; Ryan E Anson; Roland Bassett; Agop Y Bedikian; Cara Benjamin; Richard Boyd; Jade Homsi; Wen-Jen Hwu; Kevin Kim; Krishna Komanduri; Gregory Lizee; Priscilla Miller; Willem W Overwijk; Nicholas E Papadopoulos; Himabindu Pappu; Sapna P Patel; Tejal A Patel; Laszlo Radvanyi; Patrick Hwu
Chemical castration of melanoma patients does not increase the frequency of tumor-specific CD4 and CD8 T cells after peptide vaccination.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2013;36(4):276-86.
2013: Yared Hailemichael; Xue-Fei Huang; Patrick Hwu; Nina Jaffarzad; Chengwen Liu; Yanyan Lou; Wencai Ma; Miguel A Medina; Giovanni Nitti; Zhimin Dai; Richard E Davis; Stephanie M Dorta-Estremera; Nathaniel R Greeley; Weiyi Peng; Brian A Rabinovich; Kimberly Schluns; Zhiqiang Wang; Yang Ye; Willem W Overwijk
Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion.
Nature medicine 2013;19(4):465-72.
2013: Nitin Chakravarti; Patrick Hwu; Marcella M Johnson; Willem W Overwijk; Vijay G R Peddareddigari; Carla L Warneke; Victor G Prieto
Differential expression of the g-protein-coupled formyl Peptide receptor in melanoma associates with aggressive phenotype.
The American Journal of dermatopathology 2013;35(2):184-90.
2013: Dennie T Frederick; F Stephen Hodi; Patrick Hwu; Donald P Lawrence; Cecilia Lezcano; Chengwen Liu; Gregory Lizée; Devarati Mitra; George F Murphy; Lindsay P Newton; Willem W Overwijk; Weiyi Peng; Adriano Piris; Ryan J Sullivan; Andrea Boni; Alexandria P Cogdill; Zachary A Cooper; Cristina R Ferrone; David E Fisher; Keith T Flaherty; Jennifer A Wargo
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(5):1225-31.
2013: Chengwen Liu; Gregory Lizée; Yanyan Lou; Rina M Mbofung; Willem W Overwijk; Weiyi Peng; Laszlo G Radvanyi; Jennifer A Wargo; Stephanie S Watowich; Mayra Whittington; Scott E Woodman; Chunyu Xu; Yan Yang; Minying Zhang; Dennie Tompers Frederick; Jie Qing Chen; Zachary A Cooper; Michael A Davies; Keith T Flaherty; Haiyan S Li; Patrick Hwu
BRAF inhibition increases tumor infiltration by T cells and enhances the antitumor activity of adoptive immunotherapy in mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(2):393-403.
2013: Gregory Lizée; Willem W Overwijk; Laszlo G Radvanyi; Padmanee Sharma; Jianjun Gao; Patrick Hwu
Harnessing the power of the immune system to target cancer.
Annual review of medicine 2013;64():71-90.
2012: Yan Yang; Chengwen Liu; Yang Liu; Gregory Lizée; Willem W Overwijk; Weiyi Peng; Scott E Woodman; Patrick Hwu
Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40.
Blood 2012;120(23):4533-43.
2012: Weiyi Peng; Laszlo G Radvanyi; Chunyu Xu; Hideo Yagita; Yan Yang; Chengwen Liu; Gregory Lizée; Yanyan Lou; Willem W Overwijk; Jieqing Chen; Patrick Hwu
PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines.
Cancer research 2012;72(20):5209-18.
2012: Padmini Jayaraman; Masashi Kato; Esther Lopez-Rivera; Ge Ma; Willem W Overwijk; Falguni Parikh; Marcel Ramacher; David Cannan; Shu-Hsia Chen; Amelia Clark; Yared Hailemichael; Viktor Y Umansky; Andrew G Sikora
Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(11):5365-76.
2012: Chengwen Liu; Gregory Lizée; Yanyan Lou; Willem W Overwijk; Weiyi Peng; Chunyu Xu; Yan Yang; Dapeng Zhou; Alexander H Gelbard; Carol M Lewis; Patrick Hwu
Agonistic antibody to CD40 boosts the antitumor activity of adoptively transferred T cells in vivo.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2012;35(3):276-82.
2012: Andrew G Sikora; Yared Hailemichael; Willem W Overwijk
Conference scene: immune effector mechanisms in tumor immunity.
Immunotherapy 2012;4(2):141-3.
2011: Haiyan S Li; Yong-Jun Liu; Gustavo J Martinez; Hoainam Nguyen-Jackson; Willem W Overwijk; Eiji Esashi; Alexander Gelbard; Huiyuan Zhang; Stephanie S Watowich
Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response.
Blood 2011;118(14):3879-89.
2011: Richard W Joseph; Kevin Kim; Jeffrey E Lee; Ping Liu; Anthony Lucci; John D McMannis; Priscilla W Miller; Willem W Overwijk; Nicholas Papadopoulos; Vijay R Peddareddigari; Victor G Prieto; Agop Bedikian; Nebiyou B Bekele; Jeffrey E Gershenwald; Jade Homsi; Patrick Hwu; Wen-Jen Hwu; Merrick I Ross; Laszlo G Radvanyi
Impact of clinical and pathologic features on tumor-infiltrating lymphocyte expansion from surgically excised melanoma metastases for adoptive T-cell therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(14):4882-91.
2011: H J Park; Hong Qin; Soung-Chul Cha; R Sharma; Yeonseok Chung; Kimberly Schluns; Sattva S Neelapu; Willem W Overwijk; Patrick Hwu; Larry W Kwak
Induction of TLR4-dependent CD8+ T cell immunity by murine β-defensin2 fusion protein vaccines.
Vaccine 2011;29(18):3476-82.
2011: Yanyan Lou; Chengwen Liu; Gregory Lizée; Weiyi Peng; Chunyu Xu; Yang Ye; Brian A Rabinovich; Yared Hailemichael; Alexander Gelbard; Dapeng Zhou; Willem W Overwijk; Patrick Hwu
Antitumor activity mediated by CpG: the route of administration is critical.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2011;34(3):279-88.
2011: Tania G Rodríguez-Cruz; Mayra Whittington; Minying Zhang; Jahan S Khalili; Shujuan Liu; Willem W Overwijk; Gregory Lizée
Natural splice variant of MHC class I cytoplasmic tail enhances dendritic cell-induced CD8+ T-cell responses and boosts anti-tumor immunity.
PloS one 2011;6(8):e22939.
2010: Weiyi Peng; Yang Ye; Brian A Rabinovich; Chengwen Liu; Yanyan Lou; Minying Zhang; Mayra Whittington; Yan Yang; Willem W Overwijk; Gregory Lizée; Patrick Hwu
Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(22):5458-68.
2010: Loredana Frasca; Spencer W Stonier; Willem W Overwijk; Kimberly Schluns
Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types.
Journal of leukocyte biology 2010;88(1):69-78.
2010: Ling-Yuan Kong; Alexander Gelbard; Jun Wei; Chantal Reina-Ortiz; Yongtao Wang; Eric C Yang; Yared Hailemichael; Izabela Fokt; Arumugam Jayakumar; Wei Qiao; Gregory N Fuller; Willem W Overwijk; Waldemar Priebe; Amy B Heimberger
Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(9):2550-61.
2010: Andrew G Sikora; Alexander Gelbard; Michael A Davies; Daisuke Sano; Suhendan Ekmekcioglu; John Kwon; Yared Hailemichael; Padmini Jayaraman; Jeffrey N Myers; Elizabeth A Grimm; Willem W Overwijk
Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(6):1834-44.
2009: Natalia Martin-Orozco; Pawel Muranski; Yeonseok Chung; Xuexian O Yang; Tomohide Yamazaki; Sijie Lu; Patrick Hwu; Nicholas P Restifo; Willem W Overwijk; Chen Dong
T helper 17 cells promote cytotoxic T cell activation in tumor immunity.
Immunity 2009;31(5):787-98.
2009: Willem W Overwijk; Kimberly Schluns
Functions of γC cytokines in immune homeostasis: current and potential clinical applications.
Clinical immunology (Orlando, Fla.) 2009;132(2):153-65.
2009: Andrew G Sikora; Nina Jaffarzad; Yared Hailemichael; Alexander Gelbard; Spencer W Stonier; Kimberly Schluns; Loredana Frasca; Yanyan Lou; Chengwen Liu; Helen A Andersson; Patrick Hwu; Willem W Overwijk
IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(12):7398-407.
2009: Prakash Thapa; Guodong Zhang; Chengfeng Xia; Alexander Gelbard; Willem W Overwijk; Chengwen Liu; Patrick Hwu; David Z Chang; Amy Courtney; Jagannadha K Sastry; Peng G Wang; Chun Li; Dapeng Zhou
Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy.
Vaccine 2009;27(25-26):3484-8.
2008: Brian A Rabinovich; Yang Ye; Tamara Etto; Jie Qing Chen; Hyam I Levitsky; Willem W Overwijk; Laurence J N Cooper; Juri G Gelovani; Patrick Hwu
Visualizing fewer than 10 mouse T cells with an enhanced firefly luciferase in immunocompetent mouse models of cancer.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(38):14342-6.
2008: Chengwen Liu; Yanyan Lou; Gregory Lizée; Hong Qin; Shujuan Liu; Brian Rabinovich; Grace J Kim; Yi-Hong Wang; Yang Ye; Andrew G Sikora; Willem W Overwijk; Yong-Jun Liu; Gang Wang; Patrick Hwu
Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice.
The Journal of clinical investigation 2008;118(3):1165-75.
2008: John D Abad; Claudia Wrzensinski; Willem W Overwijk; Moniek A De Witte; Annelies Jorritsma; Cary Hsu; Luca Gattinoni; Cyrille Cohen; Chrystal M Paulos; Douglas Palmer; John B A G Haanen; Schumacher Ton; STEVEN ROSENBERG; Nicholas P Restifo; Richard A Morgan
T-cell receptor gene therapy of established tumors in a murine melanoma model.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(1):1-6.
2007: Kuichun Zhu; Hong Qin; Soung-Chul Cha; Sattva S Neelapu; Willem W Overwijk; Gregory A Lizee; James L Abbruzzese; Patrick Hwu; Laszlo G Radvanyi; Larry W Kwak; David Z Chang
Survivin DNA vaccine generated specific antitumor effects in pancreatic carcinoma and lymphoma mouse models.
Vaccine 2007;25(46):7955-61.
2007: Shujuan Liu; Gregory Lizée; Yanyan Lou; Chengwen Liu; Willem W Overwijk; Gang Wang; Patrick Hwu
IL-21 synergizes with IL-7 to augment expansion and anti-tumor function of cytotoxic T cells.
International immunology 2007;19(10):1213-21.
2006: Gregory Lizée; Laszlo G Radvanyi; Willem W Overwijk; Patrick Hwu
Improving antitumor immune responses by circumventing immunoregulatory cells and mechanisms.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(16):4794-803.
2006: Willem W Overwijk; Karin E de Visser; Felicia H Tirion; Laurina A de Jong; Thijs W H Pols; Yme U van der Velden; Jasper G van den Boorn; Anna M Keller; Wim A Buurman; Marc R Theoret; Bianca Blom; Nicholas P Restifo; Ada M Kruisbeek; Robert A Kastelein; John B A G Haanen
Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5213-22.
2006: Gregory Lizée; Laszlo G Radvanyi; Willem W Overwijk; Patrick Hwu
Immunosuppression in melanoma immunotherapy: potential opportunities for intervention.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 2):2359s-2365s.
2005: Willem W Overwijk
Breaking tolerance in cancer immunotherapy: time to ACT.
Current opinion in immunology 2005;17(2):187-94.
2005: Paul A Antony; Ciriaco Piccirillo; Akgül Akpinarli; Steven E Finkelstein; Paul J Speiss; Deborah R Surman; Douglas Palmer; Chi-Chao Chan; Christopher A Klebanoff; Willem W Overwijk; STEVEN ROSENBERG; Nicholas P Restifo
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2591-601.
2003: Willem W Overwijk; Marc R Theoret; Steven E Finkelstein; Deborah R Surman; Laurina A de Jong; Florry A Vyth-Dreese; Trees A Dellemijn; Paul A Antony; Paul J Spiess; Douglas Palmer; David M Heimann; Christopher A Klebanoff; Zhiya Yu; Leroy N Hwang; Lionel Feigenbaum; Ada M Kruisbeek; STEVEN ROSENBERG; Nicholas P Restifo
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.
The Journal of experimental medicine 2003;198(4):569-80.
2002: Yilin C Neeley; Kevin T McDonagh; Willem W Overwijk; Nicholas P Restifo; Martin G Sanda
Antigen-specific tumor vaccine efficacy in vivo against prostate cancer with low class I MHC requires competent class II MHC.
The Prostate 2002;53(3):183-91.
2001: Michael H Kershaw; C Hsu; W Mondesire; Linda L Parker; Gang Wang; Willem W Overwijk; Réjean Lapointe; James C Yang; Rongfu Wang; Nicholas P Restifo; Patrick Hwu
Immunization against endogenous retroviral tumor-associated antigens.
Cancer research 2001;61(21):7920-4.
2001: Willem W Overwijk; Nicholas P Restifo
B16 as a mouse model for human melanoma.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 20():Unit 20.1.
2001: J Paul Zoeteweij; Ashlee V Moses; Andrea S Rinderknecht; David A Davis; Willem W Overwijk; Robert Yarchoan; Jan M Orenstein; Andrew Blauvelt
Targeted inhibition of calcineurin signaling blocks calcium-dependent reactivation of Kaposi sarcoma-associated herpesvirus.
Blood 2001;97(8):2374-80.
2000: Willem W Overwijk; Marc R Theoret; Nicholas P Restifo
The future of interleukin-2: enhancing therapeutic anticancer vaccines.
The cancer journal from Scientific American 2000;6 Suppl 1():S76-80.
2000: Vincenzo Bronte; Elisa Apolloni; R Ronca; P Zamboni; Willem W Overwijk; Deborah R Surman; Nicholas P Restifo; Paola Zanovello
Genetic vaccination with "self" tyrosinase-related protein 2 causes melanoma eradication but not vitiligo.
Cancer research 2000;60(2):253-8.
2000: Deborah R Surman; Mark E Dudley; Willem W Overwijk; Nicholas P Restifo
Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):562-5.
2000: Willem W Overwijk; Nicholas P Restifo
Autoimmunity and the immunotherapy of cancer: targeting the "self" to destroy the "other".
Critical reviews in immunology 2000;20(6):433-50.
1999: Willem W Overwijk; David Lee; Deborah R Surman; Kari R Irvine; Christopher E Touloukian; Chi-Chao Chan; MW Carroll; Bernard Moss; STEVEN ROSENBERG; Nicholas P Restifo
Vaccination with a recombinant vaccinia virus encoding a "self" antigen induces autoimmune vitiligo and tumor cell destruction in mice: requirement for CD4(+) T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2982-7.
1999: Y C Xie; C Hwang; Willem W Overwijk; Z Zeng; M H Eng; James J Mulé; Michael J Imperiale; Nicholas P Restifo; Martin G Sanda
Induction of tumor antigen-specific immunity in vivo by a novel vaccinia vector encoding safety-modified simian virus 40 T antigen.
Journal of the National Cancer Institute 1999;91(2):169-75.
1998: MW Carroll; Willem W Overwijk; Deborah R Surman; K Tsung; Bernard Moss; Nicholas P Restifo
Construction and characterization of a triple-recombinant vaccinia virus encoding B7-1, interleukin 12, and a model tumor antigen.
Journal of the National Cancer Institute 1998;90(24):1881-7.
1998: Vincenzo Bronte; M Wang; Willem W Overwijk; Deborah R Surman; Federica Pericle; STEVEN ROSENBERG; Nicholas P Restifo
Apoptotic death of CD8+ T lymphocytes after immunization: induction of a suppressive population of Mac-1+/Gr-1+ cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(10):5313-20.
1998: Willem W Overwijk; A Tsung; Kari R Irvine; Maria R Parkhurst; Theresa J Goletz; K Tsung; MW Carroll; C Liu; Bernard Moss; STEVEN ROSENBERG; Nicholas P Restifo
gp100/pmel 17 is a murine tumor rejection antigen: induction of "self"-reactive, tumoricidal T cells using high-affinity, altered peptide ligand.
The Journal of experimental medicine 1998;188(2):277-86.
1997: CJ Kim; T Prevette; JN Cormier; Willem W Overwijk; MM Roden; Nicholas P Restifo; STEVEN ROSENBERG; Francesco M Marincola
Dendritic cells infected with poxviruses encoding MART-1/Melan A sensitize T lymphocytes in vitro.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1997;20(4):276-86.
1997: Willem W Overwijk; Deborah R Surman; K Tsung; Nicholas P Restifo
Identification of a Kb-restricted CTL epitope of beta-galactosidase: potential use in development of immunization protocols for "self" antigens.
Methods (San Diego, Calif.) 1997;12(2):117-23.
1997: Vincenzo Bronte; MW Carroll; Theresa J Goletz; M Wang; Willem W Overwijk; Francesco M Marincola; STEVEN ROSENBERG; Bernard Moss; Nicholas P Restifo
Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3183-8.
1997: MW Carroll; Willem W Overwijk; R S Chamberlain; STEVEN ROSENBERG; Bernard Moss; Nicholas P Restifo
Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model.
Vaccine 1997;15(4):387-94.
1997: Y Zhai; James C Yang; Paul J Spiess; Michael I Nishimura; Willem W Overwijk; B Roberts; Nicholas P Restifo; STEVEN ROSENBERG
Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100.
Journal of immunotherapy (Hagerstown, Md. : 1997) 1997;20(1):15-25.
1996: Bernard Moss; MW Carroll; Linda S Wyatt; Jack R Bennink; Vanessa M Hirsch; S Goldstein; W R Elkins; Thomas R Fuerst; Jeffrey D Lifson; M Piatak; Nicholas P Restifo; Willem W Overwijk; R Chamberlain; STEVEN ROSENBERG; G Sutter
Host range restricted, non-replicating vaccinia virus vectors as vaccine candidates.
Advances in experimental medicine and biology 1996;397():7-13.