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Tom Owen-Hughes

Research Profile

Chemicals & Drugs

Physiology

Anatomy

Chromatin

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Publications

TOP 3
Wei Zhang; Andrew Bowman; Hassane El-Mkami; Oleg Fedorov; Joseph Maman; Andal S Murthy; Natalia V Murzina; David G Norman; Tom Owen-Hughes; Frank Sobott; Marek Tyl; Richard Ward; Aleksandra A Watson; Ernest D Laue
Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1.
Aleksandra A Watson; Nicola Wiechens; Wei Zhang; Wenchao Zhang; Pravin Mahajan; Haydyn D T Mertens; Tom Owen-Hughes; Peter Pham; Dmitri I Svergun; Till Bartke; Georgina Berridge; Nicola A Burgess-Brown; Yun Chen; Michael J Deery; Xiuxia Du; Christian Edlich; Opher Gileadi; Tony Kouzarides; Ernest D Laue
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.
Tom Owen-Hughes; Triantafyllos Gkikopoulos
Making sense of transcribing chromatin.

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All Publications

2013: Wei Zhang; Andrew Bowman; Hassane El-Mkami; Oleg Fedorov; Joseph Maman; Andal S Murthy; Natalia V Murzina; David G Norman; Tom Owen-Hughes; Frank Sobott; Marek Tyl; Richard Ward; Aleksandra A Watson; Ernest D Laue
Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1.
Nature structural & molecular biology 2013;20(1):29-35.
2012: Aleksandra A Watson; Nicola Wiechens; Wei Zhang; Wenchao Zhang; Pravin Mahajan; Haydyn D T Mertens; Tom Owen-Hughes; Peter Pham; Dmitri I Svergun; Till Bartke; Georgina Berridge; Nicola A Burgess-Brown; Yun Chen; Michael J Deery; Xiuxia Du; Christian Edlich; Opher Gileadi; Tony Kouzarides; Ernest D Laue
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.
Journal of molecular biology 2012;422(1):3-17.
2012: Tom Owen-Hughes; Triantafyllos Gkikopoulos
Making sense of transcribing chromatin.
Current opinion in cell biology 2012;24(3):296-304.
2012: James Allan; Ross M Fraser; Tom Owen-Hughes; David Keszenman-Pereyra
Micrococcal nuclease does not substantially bias nucleosome mapping.
Journal of molecular biology 2012;417(3):152-64.
2012: Vijender Singh; Tom Owen-Hughes
Evolutionary insights into genome-wide nucleosome positioning.
Genome biology 2012;13(9):170.
2011: Daniel P Ryan; Tom Owen-Hughes
Snf2-family proteins: chromatin remodellers for any occasion.
Current opinion in chemical biology 2011;15(5):649-56.
2011: Andrew Flaus; Tom Owen-Hughes
Mechanisms for ATP-dependent chromatin remodelling: the means to the end.
The FEBS journal 2011;278(19):3579-95.
2011: Triantaffyllos Gkikopoulos; Jane Mellor; Geoffrey J Barton; Marina Pinskaya; Pieta Schofield; Vijender Singh; Michaela Smolle; Jerry L Workman; Tom Owen-Hughes
A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization.
Science (New York, N.Y.) 2011;333(6050):1758-60.
2011: Daniel P Ryan; Vijender Singh; Ramasubramanian Sundaramoorthy; David Martin; Tom Owen-Hughes
The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains.
The EMBO journal 2011;30(13):2596-609.
2011: Triantaffyllos Gkikopoulos; Vijender Singh; Kyle Tsui; Salma Awad; Matthew J Renshaw; Pieta Scholfield; Geoffrey J Barton; Corey Nislow; Tomoyuki U Tanaka; Tom Owen-Hughes
The SWI/SNF complex acts to constrain distribution of the centromeric histone variant Cse4.
The EMBO journal 2011;30(10):1919-27.
2011: Andrew Bowman; Richard Ward; Nicola Wiechens; Vijender Singh; Hassane El-Mkami; David G Norman; Tom Owen-Hughes
The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation.
Molecular cell 2011;41(4):398-408.
2011: Pawan Vinod Mehrotra; Dragana Ahel; Daniel P Ryan; Ria Weston; Nicola Wiechens; Rolf Kraehenbuehl; Tom Owen-Hughes; Ivan Ahel
DNA repair factor APLF is a histone chaperone.
Molecular cell 2011;41(1):46-55.
2010: Richard Ward; Andrew Bowman; Erman Sozudogru; Hassane El-Mkami; Tom Owen-Hughes; David G Norman
EPR distance measurements in deuterated proteins.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2010;207(1):164-7.
2010: Iestyn Whitehouse; Tom Owen-Hughes
ATRX: Put me on repeat.
Cell 2010;143(3):335-6.
2010: Salma Awad; Daniel Ryan; Philippe Prochasson; Tom Owen-Hughes; Ahmed H Hassan
The Snf2 homolog Fun30 acts as a homodimeric ATP-dependent chromatin-remodeling enzyme.
The Journal of biological chemistry 2010;285(13):9477-84.
2010: Andrew Bowman; Richard Ward; Hassane El-Mkami; Tom Owen-Hughes; David G Norman
Probing the (H3-H4)2 histone tetramer structure using pulsed EPR spectroscopy combined with site-directed spin labelling.
Nucleic acids research 2010;38(2):695-707.
2009: Heinz Neumann; Susan M Hancock; Ruth Buning; Andrew Routh; Lynda Chapman; Joanna Somers; Tom Owen-Hughes; John van Noort; Daniela Rhodes; Jason W Chin
A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation.
Molecular cell 2009;36(1):153-63.
2009: Dragana Ahel; Zuzana Horejsí; Nicola Wiechens; Sophie E Polo; Elisa Garcia-Wilson; Ivan Ahel; Helen Flynn; Mark Skehel; Stephen C West; Stephen P Jackson; Tom Owen-Hughes; Simon J Boulton
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.
Science (New York, N.Y.) 2009;325(5945):1240-3.
2009: Triantafyllos Gkikopoulos; Kristina M Havas; Hilary Dewar; Tom Owen-Hughes
SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter.
Molecular and cellular biology 2009;29(15):4057-66.
2009: Paul Hurd; Andrew J Bannister; Karen Halls; Mark A Dawson; Michiel Vermeulen; Jesper V Olsen; Heba Ismail; Joanna Somers; Matthias Mann; Tom Owen-Hughes; Ivan Gout; Tony Kouzarides
Phosphorylation of histone H3 Thr-45 is linked to apoptosis.
The Journal of biological chemistry 2009;284(24):16575-83.
2009: Joanna Somers; Tom Owen-Hughes
Mutations to the histone H3 alpha N region selectively alter the outcome of ATP-dependent nucleosome-remodelling reactions.
Nucleic acids research 2009;37(8):2504-13.
2009: Richard Ward; Andrew Bowman; Hassane El-Mkami; Tom Owen-Hughes; David G Norman
Long distance PELDOR measurements on the histone core particle.
Journal of the American Chemical Society 2009;131(4):1348-9.
2009: Maik Engeholm; Martijn de Jager; Andrew Flaus; Ruth Brenk; John van Noort; Tom Owen-Hughes
Nucleosomes can invade DNA territories occupied by their neighbors.
Nature structural & molecular biology 2009;16(2):151-8.
2009: Shirong Yu; Julia B Smirnova; Errol C Friedberg; Bruce Stillman; Masahiro Akiyama; Tom Owen-Hughes; Raymond Waters; Simon H Reed
ABF1-binding sites promote efficient global genome nucleotide excision repair.
The Journal of biological chemistry 2009;284(2):966-73.
2008: Giuseppe Lia; Marco Indrieri; Tom Owen-Hughes; Laura Finzi; Alessandro Podesta; Paolo Milani; David Dunlap
ATP-dependent looping of DNA by ISWI.
Journal of biophotonics 2008;1(4):280-6.
2007: Helder Ferreira; Andrew Flaus; Tom Owen-Hughes
Histone modifications influence the action of Snf2 family remodelling enzymes by different mechanisms.
Journal of molecular biology 2007;374(3):563-79.
2007: Helder Ferreira; Joanna Somers; Ryan Webster; Andrew Flaus; Tom Owen-Hughes
Histone tails and the H3 alphaN helix regulate nucleosome mobility and stability.
Molecular and cellular biology 2007;27(11):4037-48.
2007: Tom Owen-Hughes; Maik Engeholm
Pyrosequencing positions nucleosomes precisely.
Genome biology 2007;8(6):217.
2006: Helder Ferreira; Tom Owen-Hughes
Lighting up nucleosome spacing.
Nature structural & molecular biology 2006;13(12):1047-9.
2006: Chris Stockdale; Andrew Flaus; Helder Ferreira; Tom Owen-Hughes
Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes.
The Journal of biological chemistry 2006;281(24):16279-88.
2006: Giuseppe Lia; Elise Praly; Helder Ferreira; Chris Stockdale; Yuk-Ching Tse-Dinh; David Dunlap; Vincent Croquette; David Bensimon; Tom Owen-Hughes
Direct observation of DNA distortion by the RSC complex.
Molecular cell 2006;21(3):417-25.
2006: Harald Dürr; Andrew Flaus; Tom Owen-Hughes; Karl-Peter Hopfner
Snf2 family ATPases and DExx box helicases: differences and unifying concepts from high-resolution crystal structures.
Nucleic acids research 2006;34(15):4160-7.
2006: Andrew Flaus; David M A Martin; Geoffrey J Barton; Tom Owen-Hughes
Identification of multiple distinct Snf2 subfamilies with conserved structural motifs.
Nucleic acids research 2006;34(10):2887-905.
2006: Chris Stockdale; Michael Bruno; Helder Ferreira; Elisa Garcia-Wilson; Nicola Wiechens; Maik Engeholm; Andrew Flaus; Tom Owen-Hughes
Nucleosome dynamics.
Biochemical Society symposium 2006;(73):109-19.
2006: Tom Owen-Hughes
The role of Snf2-related proteins in cancer.
Ernst Schering Research Foundation workshop 2006;(57):47-59.
2005: humaira gowher; Chris Stockdale; Rachna Goyal; Helder Ferreira; Tom Owen-Hughes; Albert Jeltsch
De novo methylation of nucleosomal DNA by the mammalian Dnmt1 and Dnmt3A DNA methyltransferases.
Biochemistry 2005;44(29):9899-904.
2004: Kevin C Roche; Nicola Wiechens; Tom Owen-Hughes; Neil D Perkins
The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression.
Oncogene 2004;23(50):8185-95.
2004: Andrew Flaus; Tom Owen-Hughes
Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?
Current opinion in genetics & development 2004;14(2):165-73.
2004: Shirong Yu; Tom Owen-Hughes; Errol C Friedberg; Raymond Waters; Simon reed
The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair.
DNA repair 2004;3(3):277-87.
2004: Andrew Flaus; Chantal Rencurel; Helder Ferreira; Nicola Wiechens; Tom Owen-Hughes
Sin mutations alter inherent nucleosome mobility.
The EMBO journal 2004;23(2):343-53.
2004: Tom Owen-Hughes; Michael Bruno
Molecular biology. Breaking the silence.
Science (New York, N.Y.) 2004;303(5656):324-5.
2004: Michael Bruno; Andrew Flaus; Tom Owen-Hughes
Site-specific attachment of reporter compounds to recombinant histones.
Methods in enzymology 2004;375():211-28.
2003: Michael Bruno; Andrew Flaus; Chris Stockdale; Chantal Rencurel; Helder Ferreira; Tom Owen-Hughes
Histone H2A/H2B dimer exchange by ATP-dependent chromatin remodeling activities.
Molecular cell 2003;12(6):1599-606.
2003: Andrew Flaus; Tom Owen-Hughes
Dynamic properties of nucleosomes during thermal and ATP-driven mobilization.
Molecular and cellular biology 2003;23(21):7767-79.
2003: Tom Owen-Hughes
Colworth memorial lecture. Pathways for remodelling chromatin.
Biochemical Society transactions 2003;31(Pt 5):893-905.
2003: Andrew Flaus; Tom Owen-Hughes
Mechanisms for nucleosome mobilization.
Biopolymers 2003;68(4):563-78.
2003: Iestyn Whitehouse; Chris Stockdale; Andrew Flaus; Mark D Szczelkun; Tom Owen-Hughes
Evidence for DNA translocation by the ISWI chromatin-remodeling enzyme.
Molecular and cellular biology 2003;23(6):1935-45.
2002: Nathalie Rouleau; Andrii Domanskyi; Mati Reeben; Anu-Maarit Moilanen; Kristina Havas; Zhigang Kang; Tom Owen-Hughes; Jorma J Palvimo; Olli A Jänne
Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription.
Molecular biology of the cell 2002;13(6):2106-19.
2001: Kristina Havas; Iestyn Whitehouse; Tom Owen-Hughes
ATP-dependent chromatin remodeling activities.
Cellular and molecular life sciences : CMLS 2001;58(5-6):673-82.
2001: Andrew Flaus; Tom Owen-Hughes
Mechanisms for ATP-dependent chromatin remodelling.
Current opinion in genetics & development 2001;11(2):148-54.
2000: Kristina Havas; Andrew Flaus; M Phelan; R Kingston; P A Wade; D M Lilley; Tom Owen-Hughes
Generation of superhelical torsion by ATP-dependent chromatin remodeling activities.
Cell 2000;103(7):1133-42.
2000: Iestyn Whitehouse; Andrew Flaus; Kristina Havas; Tom Owen-Hughes
Mechanisms for ATP-dependent chromatin remodelling.
Biochemical Society transactions 2000;28(4):376-9.
1999: Iestyn Whitehouse; Andrew Flaus; B R Cairns; Malcolm White; J L Workman; Tom Owen-Hughes
Nucleosome mobilization catalysed by the yeast SWI/SNF complex.
Nature 1999;400(6746):784-7.