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Thomas Owen

Research Profile

Anatomy

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Rats

Physiology

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Molecular Sequence Data

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Amino Acid Sequences

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Cloning, Molecular

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Publications

TOP 3
Samir M Abdelmagid; Mary F Barbe; michael hadjiargyrou; Thomas A Owen; Roshanak Razmpour; Saqib Rehman; Steven N Popoff; Fayez F Safadi
Temporal and spatial expression of osteoactivin during fracture repair.
Maneet Singh; Fabiola Del Carpio-Cano; Joyce Y Belcher; Kevin Crawford; Nagat Frara; Thomas A Owen; Steven N Popoff; Fayez F Safadi
Functional roles of osteoactivin in normal and disease processes.
Kimberly O Cameron; Bruce A Lefker; Hua Zhu Ke; Mei Li; Michael P Zawistoski; Christina M Tjoa; Ann S Wright; Shari L DeNinno; Vishwas M Paralkar; Thomas A Owen; Li Yu; David D Thompson
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.

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All Publications

2010: Samir M Abdelmagid; Mary F Barbe; michael hadjiargyrou; Thomas A Owen; Roshanak Razmpour; Saqib Rehman; Steven N Popoff; Fayez F Safadi
Temporal and spatial expression of osteoactivin during fracture repair.
Journal of cellular biochemistry 2010;111(2):295-309.
2010: Maneet Singh; Fabiola Del Carpio-Cano; Joyce Y Belcher; Kevin Crawford; Nagat Frara; Thomas A Owen; Steven N Popoff; Fayez F Safadi
Functional roles of osteoactivin in normal and disease processes.
Critical reviews in eukaryotic gene expression 2010;20(4):341-57.
2009: Kimberly O Cameron; Bruce A Lefker; Hua Zhu Ke; Mei Li; Michael P Zawistoski; Christina M Tjoa; Ann S Wright; Shari L DeNinno; Vishwas M Paralkar; Thomas A Owen; Li Yu; David D Thompson
Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation.
Bioorganic & medicinal chemistry letters 2009;19(7):2075-8.
2008: Samir M Abdelmagid; Mary F Barbe; Mario C Rico; Sibel Salihoglu; Israel Arango-Hisijara; selim abdulhafez; Michael G Anderson; Thomas A Owen; Steven N Popoff; Fayez F Safadi
Osteoactivin, an anabolic factor that regulates osteoblast differentiation and function.
Experimental cell research 2008;314(13):2334-51.
2008: J A Arnott; X Zhang; A Sanjay; Thomas A Owen; Steven L Smock; S Rehman; William G DeLong; Fayez F Safadi; Steven N Popoff
Molecular requirements for induction of CTGF expression by TGF-beta1 in primary osteoblasts.
Bone 2008;42(5):871-85.
2007: selim abdulhafez; Julian L Castaneda; Thomas A Owen; Steven N Popoff; Fayez F Safadi
The role of osteoactivin-derived peptides in osteoblast differentiation.
Medical science monitor : international medical journal of experimental and clinical research 2007;13(12):BR259-70.
2007: Leonard Buckbinder; D Todd Crawford; Hong Qi; Hua Zhu Ke; Lisa M Olson; Kelly R Long; Peter C Bonnette; Amy P Baumann; John E Hambor; William A Grasser; Lydia C Pan; Thomas A Owen; Michael J Luzzio; Catherine A Hulford; David F Gebhard; Vishwas M Paralkar; Hollis A Simmons; John C Kath; W Gregory Roberts; Steven L Smock; Angel Guzman-Perez; Thomas Brown; Mei Li
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10619-24.
2007: Jason J Song; Rulla Aswad; Reem A Kanaan; Mario C Rico; Thomas A Owen; Mary F Barbe; Fayez F Safadi; Steven N Popoff
Connective tissue growth factor (CTGF) acts as a downstream mediator of TGF-beta1 to induce mesenchymal cell condensation.
Journal of cellular physiology 2007;210(2):398-410.
2007: Samir M Abdelmagid; Mary F Barbe; Israel Arango-Hisijara; Thomas A Owen; Steven N Popoff; Fayez F Safadi
Osteoactivin acts as downstream mediator of BMP-2 effects on osteoblast function.
Journal of cellular physiology 2007;210(1):26-37.
2006: Hua Zhu Ke; D Todd Crawford; Hong Qi; Hollis A Simmons; Thomas A Owen; Vishwas M Paralkar; Mei Li; Bihong Lu; William A Grasser; Kimberly O Cameron; Bruce A Lefker; Paul DaSilva-Jardine; Dennis O Scott; Qing Zhang; Xiao Yan Tian; Webster S S Jee; Thomas Brown; David D Thompson
A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2006;21(4):565-75.
2006: Kimberly O Cameron; Bruce A Lefker; Margaret Y Chu-Moyer; D Todd Crawford; Paul DaSilva Jardine; Shari L DeNinno; Sandra Gilbert; William A Grasser; HuaZhu Ke; Bihong Lu; Thomas A Owen; Vishwas M Paralkar; Hong Qi; Dennis O Scott; David D Thompson; Christina M Tjoa; Michael P Zawistoski
Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats.
Bioorganic & medicinal chemistry letters 2006;16(7):1799-802.
2005: Richard Chesworth; Matthew D Wessel; Lisa Heyden; F Michael Mangano; Michael P Zawistoski; Laura Gegnas; David Galluzzo; Bruce A Lefker; Kimberly O Cameron; Jeanne Tickner; Bihong Lu; Tessa A Castleberry; Donna N Petersen; Amy Brault; Pia Perry; Oicheng Ng; Thomas A Owen; Lydia Pan; Hua Zhu Ke; Thomas Brown; David D Thompson; Paul DaSilva-Jardine
Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands.
Bioorganic & medicinal chemistry letters 2005;15(24):5562-6.
2004: Richard Chesworth; Michael P Zawistoski; Bruce A Lefker; Kimberly O Cameron; Robert F Day; F Michael Mangano; Robert L Rosati; Stacy Colella; Donna N Petersen; Amy Brault; Bihong Lu; Lydia C Pan; Pia Perry; Oicheng Ng; Tessa A Castleberry; Thomas A Owen; Thomas Brown; David D Thompson; Paul DaSilva-Jardine
Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists.
Bioorganic & medicinal chemistry letters 2004;14(11):2729-33.
2003: Mei Li; Hua Zhu Ke; Hong Qi; David R Healy; Yan Li; D Todd Crawford; Vishwas M Paralkar; Thomas A Owen; Kimberly O Cameron; Bruce A Lefker; Thomas Brown; David D Thompson
A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(11):2033-42.
2003: Fayez F Safadi; Jie Xu; Steven L Smock; Reem A Kanaan; selim abdulhafez; Paul R Odgren; Sandy C Marks; Thomas A Owen; Steven N Popoff
Expression of connective tissue growth factor in bone: its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo.
Journal of cellular physiology 2003;196(1):51-62.
2003: Vishwas M Paralkar; Fran Borovecki; Hua Zhu Ke; Kimberly O Cameron; Bruce A Lefker; William A Grasser; Thomas A Owen; Mei Li; Paul DaSilva-Jardine; M Zhou; R L Dunn; F Dumont; R Korsmeyer; P Krasney; Thomas Brown; D Plowchalk; Slobodan Vukicevic; David D Thompson
An EP2 receptor-selective prostaglandin E2 agonist induces bone healing.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6736-40.
2003: selim abdulhafez; Samir M Abdelmagid; Reem A Kanaan; Steven L Smock; Thomas A Owen; Steven N Popoff; Fayez F Safadi
Anti-osteoactivin antibody inhibits osteoblast differentiation and function in vitro.
Critical reviews in eukaryotic gene expression 2003;13(2-4):265-75.
2003: Thomas A Owen; Steven L Smock; S Prakash; L Pinder; D Brees; D Krull; Tessa A Castleberry; Y C Clancy; Sandy C Marks; Fayez F Safadi; Steven N Popoff
Identification and characterization of the genes encoding human and mouse osteoactivin.
Critical reviews in eukaryotic gene expression 2003;13(2-4):205-20.
2002: Vishwas M Paralkar; William A Grasser; Amy L Mansolf; Amy P Baumann; Thomas A Owen; Steven L Smock; Snjezana Martinovic; Fran Borovecki; Slobodan Vukicevic; Hua Zhu Ke; David D Thompson
Regulation of BMP-7 expression by retinoic acid and prostaglandin E(2).
Journal of cellular physiology 2002;190(2):207-17.
2001: Bihong Lu; Steven L Smock; Tessa A Castleberry; Thomas A Owen
Molecular cloning and functional characterization of the canine androgen receptor.
Molecular and cellular biochemistry 2001;226(1-2):129-40.
2001: Mei Li; David R Healy; Yan Li; Hollis A Simmons; F Gao; Hua Zhu Ke; B Lu; Thomas A Owen; David D Thompson
A comparison of the anabolic effects of rat and bovine parathyroid hormone (1-34) in ovariectomized rats.
Journal of musculoskeletal & neuronal interactions 2001;2(1):77-83.
2001: Tessa A Castleberry; Bihong Lu; Steven L Smock; Thomas A Owen
Molecular cloning and functional characterization of the canine prostaglandin E2 receptor EP4 subtype.
Prostaglandins & other lipid mediators 2001;65(4):167-87.
2001: Steven L Smock; G A Vogt; Tessa A Castleberry; Bihong Lu; Thomas A Owen
Molecular cloning and functional characterization of the canine parathyroid hormone/parathyroid hormone related peptide receptor (PTH1).
Molecular biology reports 2001;28(4):235-43.
2001: Fayez F Safadi; Jie Xu; Steven L Smock; Mario C Rico; Thomas A Owen; Steven N Popoff
Cloning and characterization of osteoactivin, a novel cDNA expressed in osteoblasts.
Journal of cellular biochemistry 2001;84(1):12-26.
2000: Jie Xu; Steven L Smock; Fayez F Safadi; A B Rosenzweig; Paul R Odgren; Sandy C Marks; Thomas A Owen; Steven N Popoff
Cloning the full-length cDNA for rat connective tissue growth factor: implications for skeletal development.
Journal of cellular biochemistry 2000;77(1):103-15.
1999: Steven L Smock; Lydia C Pan; Tessa A Castleberry; Bihong Lu; R J Mather; Thomas A Owen
Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype.
Gene 1999;237(2):393-402.
1999: T A Hibbs; Bihong Lu; Steven L Smock; P Vestergaard; Lydia C Pan; Thomas A Owen
Molecular cloning and characterization of the canine prostaglandin E receptor EP2 subtype.
Prostaglandins & other lipid mediators 1999;57(2-3):133-47.
1998: Vishwas M Paralkar; A L Vail; William A Grasser; Thomas Brown; H Xu; Slobodan Vukicevic; Hua Zhu Ke; Hong Qi; Thomas A Owen; David D Thompson
Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.
The Journal of biological chemistry 1998;273(22):13760-7.
1998: Hua Zhu Ke; Vishwas M Paralkar; William A Grasser; D Todd Crawford; Hong Qi; Hollis A Simmons; Christine M Pirie; Kristin L Chidsey-Frink; Thomas A Owen; Steven L Smock; HK Chen; Webster S S Jee; Kimberly O Cameron; Robert L Rosati; Thomas Brown; Paul DaSilva-Jardine; David D Thompson
Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models.
Endocrinology 1998;139(4):2068-76.
1995: Michael Menconi; Shirwin M Pockwinse; Thomas A Owen; K A Dasse; Gary S Stein; Jane B Lian
Properties of blood-contacting surfaces of clinically implanted cardiac assist devices: gene expression, matrix composition, and ultrastructural characterization of cellular linings.
Journal of cellular biochemistry 1995;57(3):557-73.
1994: AR Shakoori; Andre J van Wijnen; Rita Bortell; Thomas A Owen; Janet L Stein; Jane B Lian; Gary S Stein
Variations in vitamin D receptor transcription factor complexes associated with the osteocalcin gene vitamin D responsive element in osteoblasts and osteosarcoma cells.
Journal of cellular biochemistry 1994;55(2):218-29.
1994: Rita Bortell; Thomas A Owen; R Ignotz; Gary S Stein; Janet L Stein
TGF beta 1 prevents the down-regulation of type I procollagen, fibronectin, and TGF beta 1 gene expression associated with 3T3-L1 pre-adipocyte differentiation.
Journal of cellular biochemistry 1994;54(2):256-63.
1993: A A Heinrichs; C Banerjee; Rita Bortell; Thomas A Owen; Janet L Stein; Gary S Stein; Jane B Lian
Identification and characterization of two proximal elements in the rat osteocalcin gene promoter that may confer species-specific regulation.
Journal of cellular biochemistry 1993;53(3):240-50.
1993: L M Barone; M S Tassinari; Rita Bortell; Thomas A Owen; J Zerogian; K Gagne; Gary S Stein; Jane B Lian
Inhibition of induced endochondral bone development in caffeine-treated rats.
Journal of cellular biochemistry 1993;52(2):171-82.
1993: AR Shakoori; Thomas A Owen; V Shalhoub; Janet L Stein; M Bustin; Gary S Stein; Jane B Lian
Differential expression of the chromosomal high mobility group proteins 14 and 17 during the onset of differentiation in mammalian osteoblasts and promyelocytic leukemia cells.
Journal of cellular biochemistry 1993;51(4):479-87.
1993: Rita Bortell; Thomas A Owen; V Shalhoub; A Heinrichs; M A Aronow; Cécile Rochette-Egly; Yves Lutz; Janet L Stein; Jane B Lian; Gary S Stein
Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2300-4.
1993: Thomas A Owen; Rita Bortell; V Shalhoub; A Heinrichs; Janet L Stein; Gary S Stein; Jane B Lian
Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(4):1503-7.
1992: Rita Bortell; Thomas A Owen; J P Bidwell; P Gavazzo; E Breen; Andre J van Wijnen; H F DeLuca; Janet L Stein; Jane B Lian; Gary S Stein
Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6119-23.
1992: AR Shakoori; A M Oberdorf; Thomas A Owen; Lee A Weber; E Hickey; Janet L Stein; Jane B Lian; Gary S Stein
Expression of heat shock genes during differentiation of mammalian osteoblasts and promyelocytic leukemia cells.
Journal of cellular biochemistry 1992;48(3):277-87.
1991: Gary S Stein; Jane B Lian; S I Dworetzky; Thomas A Owen; Rita Bortell; J P Bidwell; Andre J van Wijnen
Regulation of transcription-factor activity during growth and differentiation: involvement of the nuclear matrix in concentration and localization of promoter binding proteins.
Journal of cellular biochemistry 1991;47(4):300-5.
1991: G Schepmoes; E Breen; Thomas A Owen; M A Aronow; Gary S Stein; Jane B Lian
Influence of dexamethasone on the vitamin D-mediated regulation of osteocalcin gene expression.
Journal of cellular biochemistry 1991;47(2):184-96.
1991: L M Barone; Thomas A Owen; M S Tassinari; Rita Bortell; Gary S Stein; Jane B Lian
Developmental expression and hormonal regulation of the rat matrix Gla protein (MGP) gene in chondrogenesis and osteogenesis.
Journal of cellular biochemistry 1991;46(4):351-65.
1991: Andre J van Wijnen; Thomas A Owen; J Holthuis; Jane B Lian; Janet L Stein; Gary S Stein
Coordination of protein-DNA interactions in the promoters of human H4, H3, and H1 histone genes during the cell cycle, tumorigenesis, and development.
Journal of cellular physiology 1991;148(1):174-89.
1991: Andre J van Wijnen; A L Ramsey-Ewing; Rita Bortell; Thomas A Owen; Jane B Lian; Janet L Stein; Gary S Stein
Transcriptional element H4-site II of cell cycle regulated human H4 histone genes is a multipartite protein/DNA interaction site for factors HiNF-D, HiNF-M, and HiNF-P: involvement of phosphorylation.
Journal of cellular biochemistry 1991;46(2):174-89.
1991: Andre J van Wijnen; T K Choi; Thomas A Owen; K L Wright; Jane B Lian; Rudolf Jaenisch; Janet L Stein; Gary S Stein
Involvement of the cell cycle-regulated nuclear factor HiNF-D in cell growth control of a human H4 histone gene during hepatic development in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2573-7.
1991: Thomas A Owen; M S Aronow; L M Barone; B Bettencourt; Gary S Stein; Jane B Lian
Pleiotropic effects of vitamin D on osteoblast gene expression are related to the proliferative and differentiated state of the bone cell phenotype: dependency upon basal levels of gene expression, duration of exposure, and bone matrix competency in normal rat osteoblast cultures.
Endocrinology 1991;128(3):1496-504.
1991: Jane B Lian; Gary S Stein; Rita Bortell; Thomas A Owen
Phenotype suppression: a postulated molecular mechanism for mediating the relationship of proliferation and differentiation by Fos/Jun interactions at AP-1 sites in steroid responsive promoter elements of tissue-specific genes.
Journal of cellular biochemistry 1991;45(1):9-14.
1990: Thomas A Owen; Rita Bortell; S A Yocum; Steven L Smock; M Zhang; C Abate; V Shalhoub; Neil Aronin; K L Wright; Andre J van Wijnen
Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9990-4.
1990: G S Stein; J B Lian; Thomas A Owen
Bone cell differentiation: a functionally coupled relationship between expression of cell-growth- and tissue-specific genes.
Current opinion in cell biology 1990;2(6):1018-27.
1990: Gary S Stein; Jane B Lian; Thomas A Owen
Relationship of cell growth to the regulation of tissue-specific gene expression during osteoblast differentiation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1990;4(13):3111-23.
1990: Thomas A Owen; J Holthuis; E Markose; Andre J van Wijnen; S A Wolfe; Sidney Grimes; Jane B Lian; Gary S Stein
Modifications of protein-DNA interactions in the proximal promoter of a cell-growth-regulated histone gene during onset and progression of osteoblast differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(13):5129-33.
1990: Thomas A Owen; M Aronow; V Shalhoub; L M Barone; L Wilming; M S Tassinari; M B Kennedy; Shirwin M Pockwinse; Jane B Lian; Gary S Stein
Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix.
Journal of cellular physiology 1990;143(3):420-30.
1990: M A Aronow; L C Gerstenfeld; Thomas A Owen; M S Tassinari; Gary S Stein; Jane B Lian
Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells.
Journal of cellular physiology 1990;143(2):213-21.
1990: J Holthuis; Thomas A Owen; Andre J van Wijnen; K L Wright; A Ramsey-Ewing; M B Kennedy; R Carter; Stephen C Cosenza; K J Soprano; Jane B Lian
Tumor cells exhibit deregulation of the cell cycle histone gene promoter factor HiNF-D.
Science (New York, N.Y.) 1990;247(4949 Pt 1):1454-7.
1990: Thomas A Owen; R Carter; M M Whitman; Dianne Robert Soprano; Kenneth J Soprano
Evidence that density-dependent growth arrest is a two-stage process in WI-38 cells.
Journal of cellular physiology 1990;142(1):137-48.
1989: Thomas A Owen; Dianne Robert Soprano; Kenneth J Soprano
Analysis of the growth factor requirements for stimulation of WI-38 cells after extended periods of density-dependent growth arrest.
Journal of cellular physiology 1989;139(2):424-31.
1989: Thomas A Owen; Stephen C Cosenza; Dianne Robert Soprano; Kenneth J Soprano
Evidence that stimulation of growth following long term density arrest of WI-38 cells proceeds via a pathway independent of protein kinase C and of cAMP-dependent protein kinase.
Oncogene research 1989;4(2):137-47.
1988: Stephen C Cosenza; Thomas A Owen; Dianne Robert Soprano; Kenneth J Soprano
Evidence that the time of entry into S is determined by events occurring in early G1.
The Journal of biological chemistry 1988;263(25):12751-8.
1988: S Ferrari; Bruno Calabretta; R Battini; Stephen C Cosenza; Thomas A Owen; Kenneth J Soprano; Renato Baserga
Expression of c-myc and induction of DNA synthesis by platelet-poor plasma in human diploid fibroblasts.
Experimental cell research 1988;174(1):25-33.
1987: Thomas A Owen; Stephen C Cosenza; Dianne Robert Soprano; Kenneth J Soprano
Time of c-fos and c-myc expression in human diploid fibroblasts stimulated to proliferate after prolonged periods in quiescence.
The Journal of biological chemistry 1987;262(31):15111-7.
1987: A Toscani; Dianne Robert Soprano; Stephen C Cosenza; Thomas A Owen; Kenneth J Soprano
Normalization of multiple RNA samples using an in vitro-synthesized external standard cRNA.
Analytical biochemistry 1987;165(2):309-19.