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Gary Owens

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Delphine Gomez; Anh T Nguyen; Laura S Shankman; Gary K Owens
Detection of histone modifications at specific gene loci in single cells in histological sections.
Anh T Nguyen; Robert D Bell; Julie H Campbell; Alexander W Clowes; Giulio Gabbiani; Cecilia M Giachelli; Delphine Gomez; Joseph M Miano; Michael S Parmacek; Elaine W Raines; Nancy J Rusch; Mei Y Speer; Michael Sturek; Johan Thyberg; Dwight A Towler; Mary C Weiser-Evans; Chen Yan; Gary K Owens
Smooth muscle cell plasticity: fact or fiction?
Morgan Salmon; Laura Shankman; Delphine Gomez; Elizabeth Greene; Gary K Owens
Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo.

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All Publications

2013: Delphine Gomez; Anh T Nguyen; Laura S Shankman; Gary K Owens
Detection of histone modifications at specific gene loci in single cells in histological sections.
Nature methods 2013;10(2):171-7.
2013: Anh T Nguyen; Robert D Bell; Julie H Campbell; Alexander W Clowes; Giulio Gabbiani; Cecilia M Giachelli; Delphine Gomez; Joseph M Miano; Michael S Parmacek; Elaine W Raines; Nancy J Rusch; Mei Y Speer; Michael Sturek; Johan Thyberg; Dwight A Towler; Mary C Weiser-Evans; Chen Yan; Gary K Owens
Smooth muscle cell plasticity: fact or fiction?
Circulation research 2013;112(1):17-22.
2012: Morgan Salmon; Laura Shankman; Delphine Gomez; Elizabeth Greene; Gary K Owens
Cooperative binding of KLF4, pELK-1, and HDAC2 to a G/C repressor element in the SM22α promoter mediates transcriptional silencing during SMC phenotypic switching in vivo.
Circulation research 2012;111(6):685-96.
2012: Delphine Gomez; Gary K Owens
Smooth muscle cell phenotypic switching in atherosclerosis.
Cardiovascular research 2012;95(2):156-64.
2012: Matthew R Alexander; Christopher W Moehle; Meera Murgai; Gary K Owens
Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms.
Physiological genomics 2012;44(7):417-29.
2012: Matthew R Alexander; Gary K Owens
Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease.
Annual review of physiology 2012;74():13-40.
2011: Christopher W Moehle; Gary K Owens; Morgan Salmon; Gilbert R Upchurch Jr; Matthew R Alexander; Castigliano M Bhamidipati; James N Irvine; Irving L Kron; Gaurav S Mehta; Gorav Ailawadi
Bone marrow-derived MCP1 required for experimental aortic aneurysm formation and smooth muscle phenotypic modulation.
The Journal of thoracic and cardiovascular surgery 2011;142(6):1567-74.
2011: Mark H Hoofnagle; Ronald L Neppl; Erica L Berzin; G C Teg Pipes; Eric N Olson; Brian W Wamhoff; Avril V Somlyo; Gary K Owens
Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2011;300(5):H1707-21.
2010: Tadashi Yoshida; Qiong Gan; Aaron S Franke; Ruoya Ho; Jifeng Zhang; Y Eugene Chen; Matsuhiko Hayashi; Mark W Majesky; Avril V Somlyo; Gary K Owens
Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation.
The Journal of biological chemistry 2010;285(27):21175-84.
2010: Li Jin; Qiong Gan; Bartosz J Zieba; Silvia M Goicoechea; Gary K Owens; Carol A Otey; Avril V Somlyo
The actin associated protein palladin is important for the early smooth muscle cell differentiation.
PloS one 2010;5(9):e12823.
2009: Gorav Ailawadi; Christopher W Moehle; Hong Pei; Sandra P Walton; Zequan Yang; Irving L Kron; Christine L Lau; Gary K Owens
Smooth muscle phenotypic modulation is an early event in aortic aneurysms.
The Journal of thoracic and cardiovascular surgery 2009;138(6):1392-9.
2009: Meghan M Nickerson; Ji Song; Joshua Keith Meisner; Sameer Bajikar; Caitlin W Burke; Casey W Shuptrine; Gary K Owens; Thomas C Skalak; Richard J Price
Bone marrow-derived cell-specific chemokine (C-C motif) receptor-2 expression is required for arteriolar remodeling.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(11):1794-801.
2009: Rebecca A Deaton; Qiong Gan; Gary K Owens
Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle.
American journal of physiology. Heart and circulatory physiology 2009;296(4):H1027-37.
2009: Olga A Cherepanova; Nataliya A Pidkovka; Olga F Sarmento; Tadashi Yoshida; Qiong Gan; Eser Adiguzel; Michelle P Bendeck; Judith Berliner; Norbert Leitinger; Gary K Owens
Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration.
Circulation research 2009;104(5):609-18.
2009: James A Thomas; Rebecca A Deaton; Nicole E Hastings; Yueting Shang; Christopher W Moehle; Ulf Eriksson; Stavros Topouzis; Brian R Wamhoff; Brett R Blackman; Gary K Owens
PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.
American journal of physiology. Heart and circulatory physiology 2009;296(2):H442-52.
2009: Li Jin; Tadashi Yoshida; Ruoya Ho; Gary K Owens; Avril V Somlyo
The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies.
The Journal of biological chemistry 2009;284(4):2121-30.
2008: Tadashi Yoshida; Qiong Gan; Gary K Owens
Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids.
American journal of physiology. Cell physiology 2008;295(5):C1175-82.
2008: Brian R Wamhoff; Kevin R Lynch; Timothy L MacDonald; Gary K Owens
Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(8):1454-61.
2008: Tadashi Yoshida; Klaus kaestner; Gary K Owens
Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury.
Circulation research 2008;102(12):1548-57.
2008: Yueting Shang; Tadashi Yoshida; Brad A Amendt; James F Martin; Gary K Owens
Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation.
The Journal of cell biology 2008;181(3):461-73.
2007: Qiong Gan; Tadashi Yoshida; Jian Li; Gary K Owens
Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression.
Circulation research 2007;101(9):883-92.
2007: Nataliya A Pidkovka; Olga A Cherepanova; Tadashi Yoshida; Matthew R Alexander; Rebecca A Deaton; James A Thomas; Norbert Leitinger; Gary K Owens
Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro.
Circulation research 2007;101(8):792-801.
2007: Oliver G McDonald; Gary K Owens
Programming smooth muscle plasticity with chromatin dynamics.
Circulation research 2007;100(10):1428-41.
2007: Yongbo Liao; christopher regan; Ichiro Manabe; Gary K Owens; Kathleen H Day; David N Damon; Brian R Duling
Smooth muscle-targeted knockout of connexin43 enhances neointimal formation in response to vascular injury.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(5):1037-42.
2007: C Huie Lin; Mark D Platt; Scott B Ficarro; Mark H Hoofnagle; Jeffrey Shabanowitz; Lucio Comai; Donald F Hunt; Gary K Owens
Mass spectrometric identification of phosphorylation sites of rRNA transcription factor upstream binding factor.
American journal of physiology. Cell physiology 2007;292(5):C1617-24.
2007: Tadashi Yoshida; Qiong Gan; Yueting Shang; Gary K Owens
Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promoters.
American journal of physiology. Cell physiology 2007;292(2):C886-95.
2007: Gary K Owens
Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity.
Novartis Foundation symposium 2007;283():174-91; discussion 191-3, 238-41.
2007: Brian R Wamhoff; S Sinha; Gary K Owens
Conditional mouse models to study developmental and pathophysiological gene function in muscle.
Handbook of experimental pharmacology 2007;(178):441-68.
2007: Qiong Gan; Tadashi Yoshida; Oliver G McDonald; Gary K Owens
Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells.
Stem cells (Dayton, Ohio) 2007;25(1):2-9.
2007: Keiko Kawai-Kowase; Gary K Owens
Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells.
American journal of physiology. Cell physiology 2007;292(1):C59-69.
2006: Mark H Hoofnagle; James A Thomas; Brian R Wamhoff; Gary K Owens
Origin of neointimal smooth muscle: we've come full circle.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(12):2579-81.
2006: Sanjay Sinha; Brian R Wamhoff; Mark H Hoofnagle; James Thomas; Ronald L Neppl; Thomas Deering; Brian P Helmke; Douglas K Bowles; Avril V Somlyo; Gary K Owens
Assessment of contractility of purified smooth muscle cells derived from embryonic stem cells.
Stem cells (Dayton, Ohio) 2006;24(7):1678-88.
2006: Brian R Wamhoff; Douglas K Bowles; Gary K Owens
Excitation-transcription coupling in arterial smooth muscle.
Circulation research 2006;98(7):868-78.
2006: Christopher A Davis; Michael Haberland; Michael A Arnold; Lillian B Sutherland; Oliver G McDonald; James A Richardson; Geoffrey Childs; Stephen Harris; Gary K Owens; Eric N Olson
PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells.
Molecular and cellular biology 2006;26(7):2626-36.
2006: Isabelle Gorenne; Li Jin; Tadashi Yoshida; John M Sanders; Ian J Sarembock; Gary K Owens; Andrew P Somlyo; Avril V Somlyo
LPP expression during in vitro smooth muscle differentiation and stent-induced vascular injury.
Circulation research 2006;98(3):378-85.
2006: Alexander S Khromov; H Wang; Nandini Choudhury; Marcia McDuffie; B P Herring; Robert K Nakamoto; Gary K Owens; Andrew P Somlyo; Avril V Somlyo
Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(7):2440-5.
2006: Oliver G McDonald; Brian R Wamhoff; Mark H Hoofnagle; Gary K Owens
Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo.
The Journal of clinical investigation 2006;116(1):36-48.
2005: G C Teg Pipes; Sanjay Sinha; Xiaoxia Qi; Chun-Hong Zhu; Teresa D Gallardo; John Shelton; Esther Creemers; Lillian Sutherland; James A Richardson; Daniel J Garry; Woodring E Wright; Gary K Owens; Eric N Olson
Stem cells and their derivatives can bypass the requirement of myocardin for smooth muscle gene expression.
Developmental biology 2005;288(2):502-13.
2005: Thomas J O'Neill; Brian R Wamhoff; Gary K Owens; Thomas C Skalak
Mobilization of bone marrow-derived cells enhances the angiogenic response to hypoxia without transdifferentiation into endothelial cells.
Circulation research 2005;97(10):1027-35.
2005: Keiko Kawai-Kowase; Meena S Kumar; Mark H Hoofnagle; Tadashi Yoshida; Gary K Owens
PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins.
Molecular and cellular biology 2005;25(18):8009-23.
2005: Yan Liu; Sanjay Sinha; Oliver G McDonald; Yueting Shang; Mark H Hoofnagle; Gary K Owens
Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression.
The Journal of biological chemistry 2005;280(10):9719-27.
2005: Tadashi Yoshida; Gary K Owens
Molecular determinants of vascular smooth muscle cell diversity.
Circulation research 2005;96(3):280-91.
2005: Jennifer A Hendrix; Brian R Wamhoff; Oliver G McDonald; Sanjay Sinha; Tadashi Yoshida; Gary K Owens
5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo.
The Journal of clinical investigation 2005;115(2):418-27.
2005: Demetra Perlegas; Hui Xie; Sanjay Sinha; Avril V Somlyo; Gary K Owens
ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development.
American journal of physiology. Heart and circulatory physiology 2005;288(1):H96-102.
2004: Sanjay Sinha; Mark H Hoofnagle; Paul Andrew Kingston; Mary E McCanna; Gary K Owens
Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells.
American journal of physiology. Cell physiology 2004;287(6):C1560-8.
2004: Brian R Wamhoff; Mark H Hoofnagle; A Burns; Sanjay Sinha; Oliver G McDonald; Gary K Owens
A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis.
Circulation research 2004;95(10):981-8.
2004: Tadashi Yoshida; Keiko Kawai-Kowase; Gary K Owens
Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1596-601.
2004: Brian R Wamhoff; Douglas K Bowles; Oliver G McDonald; Sanjay Sinha; Andrew P Somlyo; Avril V Somlyo; Gary K Owens
L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism.
Circulation research 2004;95(4):406-14.
2004: Gary K Owens; Meena S Kumar; Brian R Wamhoff
Molecular regulation of vascular smooth muscle cell differentiation in development and disease.
Physiological reviews 2004;84(3):767-801.
2004: Frédéric Dandré; Gary K Owens
Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes.
American journal of physiology. Heart and circulatory physiology 2004;286(6):H2042-51.
2004: Mark H Hoofnagle; Brian R Wamhoff; Gary K Owens
Lost in transdifferentiation.
The Journal of clinical investigation 2004;113(9):1249-51.
2004: Tadashi Yoshida; Mark H Hoofnagle; Gary K Owens
Myocardin and Prx1 contribute to angiotensin II-induced expression of smooth muscle alpha-actin.
Circulation research 2004;94(8):1075-82.
2004: Avril V Somlyo; H Wang; Nandini Choudhury; Alexander S Khromov; Mark W Majesky; Gary K Owens; Andrew P Somlyo
Myosin light chain kinase knockout.
Journal of muscle research and cell motility 2004;25(3):241-2.
2003: Meena S Kumar; Jennifer A Hendrix; A Daniel Johnson; Gary K Owens
Smooth muscle alpha-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins.
Circulation research 2003;92(8):840-7.
2003: Tadashi Yoshida; Sanjay Sinha; Frédéric Dandré; Brian R Wamhoff; Mark H Hoofnagle; Brandon E Kremer; Dazhi Wang; Eric N Olson; Gary K Owens
Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes.
Circulation research 2003;92(8):856-64.
2003: Meena S Kumar; Gary K Owens
Combinatorial control of smooth muscle-specific gene expression.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(5):737-47.
2001: Ichiro Manabe; Gary K Owens
The smooth muscle myosin heavy chain gene exhibits smooth muscle subtype-selective modular regulation in vivo.
The Journal of biological chemistry 2001;276(42):39076-87.
2001: Ichiro Manabe; Gary K Owens
Recruitment of serum response factor and hyperacetylation of histones at smooth muscle-specific regulatory regions during differentiation of a novel P19-derived in vitro smooth muscle differentiation system.
Circulation research 2001;88(11):1127-34.
2001: Ichiro Manabe; Gary K Owens
CArG elements control smooth muscle subtype-specific expression of smooth muscle myosin in vivo.
The Journal of clinical investigation 2001;107(7):823-34.
2001: Joan M Taylor; Christopher P Mack; K Nolan; christopher regan; Gary K Owens; Thomas J Parsons
Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells.
Molecular and cellular biology 2001;21(5):1565-72.
2001: Christopher P Mack; Avril V Somlyo; MB Hautmann; Andrew P Somlyo; Gary K Owens
Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization.
The Journal of biological chemistry 2001;276(1):341-7.
2000: PJ Adam; christopher regan; MB Hautmann; Gary K Owens
Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo.
The Journal of biological chemistry 2000;275(48):37798-806.
2000: christopher regan; PJ Adam; CS Madsen; Gary K Owens
Molecular mechanisms of decreased smooth muscle differentiation marker expression after vascular injury.
The Journal of clinical investigation 2000;106(9):1139-47.
2000: christopher regan; Ichiro Manabe; Gary K Owens
Development of a smooth muscle-targeted cre recombinase mouse reveals novel insights regarding smooth muscle myosin heavy chain promoter regulation.
Circulation research 2000;87(5):363-9.
2000: Christopher P Mack; M M Thompson; S Lawrenz-Smith; Gary K Owens
Smooth muscle alpha-actin CArG elements coordinate formation of a smooth muscle cell-selective, serum response factor-containing activation complex.
Circulation research 2000;86(2):221-32.
2000: PJ Wiegman; WL Barry; John A McPherson; Coleen A McNamara; Lawrence W Gimple; John M Sanders; Gregory G Bishop; Eric Randall Powers; Michael Ragosta; Gary K Owens; Ian J Sarembock
All-trans-retinoic acid limits restenosis after balloon angioplasty in the focally atherosclerotic rabbit : a favorable effect on vessel remodeling.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(1):89-95.
1999: F Jung; A D Johnson; Meena S Kumar; B Wei; MB Hautmann; Gary K Owens; Coleen A McNamara
Characterization of an E-box-dependent cis element in the smooth muscle alpha-actin promoter.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(11):2591-9.
1999: Gregory G Bishop; PJ Wiegman; Coleen A McNamara; S Din; J Sanders; sean hesselbacher; Marc D Feldman; John A McPherson; JE Humphries; Marie-Louise Hammarskjold; Lawrence W Gimple; Michael Ragosta; Eric Randall Powers; D Dickek; Gary K Owens; Ian J Sarembock
Local adenovirus-mediated delivery of hirudin in a rabbit arterial injury model.
Journal of vascular research 1999;36(5):343-52; discussion 430-3.
1999: MB Hautmann; PJ Adam; Gary K Owens
Similarities and differences in smooth muscle alpha-actin induction by TGF-beta in smooth muscle versus non-smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2049-58.
1999: Christopher P Mack; Gary K Owens
Regulation of smooth muscle alpha-actin expression in vivo is dependent on CArG elements within the 5' and first intron promoter regions.
Circulation research 1999;84(7):852-61.
1998: A J Kihm; J C Hershey; Timothy A J Haystead; C S Madsen; Gary K Owens
Phosphorylation of the rRNA transcription factor upstream binding factor promotes its association with TATA binding protein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14816-20.
1998: L M Thome; Lawrence W Gimple; B G Bachhuber; Coleen A McNamara; Michael Ragosta; S David Gertz; Eric Randall Powers; Gary K Owens; JE Humphries; Ian J Sarembock
Early plus delayed hirudin reduces restenosis in the atherosclerotic rabbit more than early administration alone: potential implications for dosing of antithrombin agents.
Circulation 1998;98(21):2301-6.
1998: E A Swartz; A D Johnson; Gary K Owens
Two MCAT elements of the SM alpha-actin promoter function differentially in SM vs. non-SM cells.
The American journal of physiology 1998;275(2 Pt 1):C608-18.
1998: CS Madsen; christopher regan; JE Hungerford; Sheryl White; Ichiro Manabe; Gary K Owens
Smooth muscle-specific expression of the smooth muscle myosin heavy chain gene in transgenic mice requires 5'-flanking and first intronic DNA sequence.
Circulation research 1998;82(8):908-17.
1998: MB Hautmann; CS Madsen; Christopher P Mack; Gary K Owens
Substitution of the degenerate smooth muscle (SM) alpha-actin CC(A/T-rich)6GG elements with c-fos serum response elements results in increased basal expression but relaxed SM cell specificity and reduced angiotensin II inducibility.
The Journal of biological chemistry 1998;273(14):8398-406.
1997: S David Gertz; WL Barry; Lawrence W Gimple; Shmuel Banai; Louise S Perez; C A McNamara; Eric Randall Powers; Michael Ragosta; Gary K Owens; W C Roberts; Ian J Sarembock
Predictors of luminal narrowing by neointima after angioplasty in atherosclerotic rabbits.
Cardiovascular research 1997;36(3):396-407.
1997: CS Madsen; christopher regan; Gary K Owens
Interaction of CArG elements and a GC-rich repressor element in transcriptional regulation of the smooth muscle myosin heavy chain gene in vascular smooth muscle cells.
The Journal of biological chemistry 1997;272(47):29842-51.
1997: MB Hautmann; M M Thompson; E A Swartz; E N Olson; Gary K Owens
Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox.
Circulation research 1997;81(4):600-10.
1997: WL Barry; PJ Wiegman; Lawrence W Gimple; S David Gertz; Eric Randall Powers; Gary K Owens; Ian J Sarembock
A new single-injury model of balloon angioplasty in cholesterol-fed rabbits: beneficial effect of hirudin and comparison with double-injury model.
Laboratory investigation; a journal of technical methods and pathology 1997;77(1):109-16.
1997: MB Hautmann; CS Madsen; Gary K Owens
A transforming growth factor beta (TGFbeta) control element drives TGFbeta-induced stimulation of smooth muscle alpha-actin gene expression in concert with two CArG elements.
The Journal of biological chemistry 1997;272(16):10948-56.
1997: CS Madsen; J C Hershey; MB Hautmann; Sheryl White; Gary K Owens
Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich element located between two positive-acting serum response factor-binding elements.
The Journal of biological chemistry 1997;272(10):6332-40.
1997: S M Vernon; M J Campos; T Haystead; M M Thompson; P E DiCorleto; Gary K Owens
Endothelial cell-conditioned medium downregulates smooth muscle contractile protein expression.
The American journal of physiology 1997;272(2 Pt 1):C582-91.
1997: B G Bachhuber; Ian J Sarembock; Lawrence W Gimple; Gary K Owens
alpha-Thrombin induces transforming growth factor-beta1 mRNA and protein in cultured vascular smooth muscle cells via a proteolytically activated receptor.
Journal of vascular research 1997;34(1):41-8.
1996: Gary K Owens; S M Vernon; C S Madsen
Molecular regulation of smooth muscle cell differentiation.
Journal of hypertension. Supplement : official journal of the International Society of Hypertension 1996;14(5):S55-64.
1996: JE Hungerford; Gary K Owens; Scott Argraves; Charles D Little
Development of the aortic vessel wall as defined by vascular smooth muscle and extracellular matrix markers.
Developmental biology 1996;178(2):375-92.
1996: WL Barry; Lawrence W Gimple; JE Humphries; Eric Randall Powers; K W McCoy; John M Sanders; Gary K Owens; Ian J Sarembock
Arterial thrombin activity after angioplasty in an atherosclerotic rabbit model: time course and effect of hirudin.
Circulation 1996;94(1):88-93.
1996: Michael Ragosta; WL Barry; Lawrence W Gimple; S David Gertz; K W McCoy; George A Stouffer; Coleen A McNamara; Eric Randall Powers; Gary K Owens; Ian J Sarembock
Effect of thrombin inhibition with desulfatohirudin on early kinetics of cellular proliferation after balloon angioplasty in atherosclerotic rabbits.
Circulation 1996;93(6):1194-200.
1996: Coleen A McNamara; Ian J Sarembock; B G Bachhuber; George A Stouffer; Michael Ragosta; W Barry; Lawrence W Gimple; Eric Randall Powers; Gary K Owens
Thrombin and vascular smooth muscle cell proliferation: implications for atherosclerosis and restenosis.
Seminars in thrombosis and hemostasis 1996;22(2):139-44.
1995: Alissa M Weaver; Gary K Owens; Steven L Gonias
Native and activated forms of alpha 2-macroglobulin increase expression of platelet-derived growth factor alpha-receptor in vascular smooth muscle cells. Evidence for autocrine transforming growth factor-beta activity.
The Journal of biological chemistry 1995;270(51):30741-8.
1995: Donna J Webb; Isa M Hussaini; Alissa M Weaver; T L Atkins; C T Chu; S V Pizzo; Gary K Owens; Steven L Gonias
Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity.
European journal of biochemistry / FEBS 1995;234(3):714-22.
1995: J C Hershey; MB Hautmann; M M Thompson; Lawrence Rothblum; Timothy A J Haystead; Gary K Owens
Angiotensin II-induced hypertrophy of rat vascular smooth muscle is associated with increased 18 S rRNA synthesis and phosphorylation of the rRNA transcription factor, upstream binding factor.
The Journal of biological chemistry 1995;270(42):25096-101.
1995: R E Lesh; Andrew P Somlyo; Gary K Owens; Avril V Somlyo
Reversible permeabilization. A novel technique for the intracellular introduction of antisense oligodeoxynucleotides into intact smooth muscle.
Circulation research 1995;77(2):220-30.
1995: Gary K Owens
Regulation of differentiation of vascular smooth muscle cells.
Physiological reviews 1995;75(3):487-517.
1995: Coleen A McNamara; M M Thompson; S M Vernon; R T Shimizu; R S Blank; Gary K Owens
Nuclear proteins bind a cis-acting element in the smooth muscle alpha-actin promoter.
The American journal of physiology 1995;268(5 Pt 1):C1259-66.
1995: B G Bachhuber; Ian J Sarembock; Lawrence W Gimple; Coleen A McNamara; Gary K Owens
Thrombin-induced mitogenesis in cultured aortic smooth muscle cells requires prolonged thrombin exposure.
The American journal of physiology 1995;268(5 Pt 1):C1141-7.
1995: R S Blank; E A Swartz; M M Thompson; E N Olson; Gary K Owens
A retinoic acid-induced clonal cell line derived from multipotential P19 embryonal carcinoma cells expresses smooth muscle characteristics.
Circulation research 1995;76(5):742-9.
1995: R T Shimizu; R S Blank; R Jervis; S C Lawrenz-Smith; Gary K Owens
The smooth muscle alpha-actin gene promoter is differentially regulated in smooth muscle versus non-smooth muscle cells.
The Journal of biological chemistry 1995;270(13):7631-43.
1994: Richard J Price; Gary K Owens; Thomas C Skalak
Immunohistochemical identification of arteriolar development using markers of smooth muscle differentiation. Evidence that capillary arterialization proceeds from terminal arterioles.
Circulation research 1994;75(3):520-7.
1994: George A Stouffer; Gary K Owens
TGF-beta promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms.
The Journal of clinical investigation 1994;93(5):2048-55.
1993: George A Stouffer; Ian J Sarembock; Coleen A McNamara; Lawrence W Gimple; Gary K Owens
Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA.
The American journal of physiology 1993;265(3 Pt 1):C806-11.
1993: George A Stouffer; Jonathan LaMarre; Steven L Gonias; Gary K Owens
Activated alpha 2-macroglobulin and transforming growth factor-beta 1 induce a synergistic smooth muscle cell proliferative response.
The Journal of biological chemistry 1993;268(24):18340-4.
1993: P L Monical; Gary K Owens; Richard A Murphy
Expression of myosin regulatory light-chain isoforms and regulation of phosphorylation in smooth muscle.
The American journal of physiology 1993;264(6 Pt 1):C1466-72.
1993: B J Holycross; M J Peach; Gary K Owens
Angiotensin II stimulates increased protein synthesis, not increased DNA synthesis, in intact rat aortic segments, in vitro.
Journal of vascular research 1993;30(2):80-6.
1993: George A Stouffer; R T Shimizu; M B Turla; Gary K Owens
ANG II- or AVP-induced increases in protein synthesis are not dependent on autocrine secretion of PDGF-AA.
The American journal of physiology 1993;264(2 Pt 1):C390-5.
1993: Coleen A McNamara; Ian J Sarembock; Lawrence W Gimple; J W Fenton; S R Coughlin; Gary K Owens
Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.
The Journal of clinical investigation 1993;91(1):94-8.
1992: B J Holycross; R S Blank; M M Thompson; M J Peach; Gary K Owens
Platelet-derived growth factor-BB-induced suppression of smooth muscle cell differentiation.
Circulation research 1992;71(6):1525-32.
1992: George A Stouffer; Gary K Owens
Angiotensin II-induced mitogenesis of spontaneously hypertensive rat-derived cultured smooth muscle cells is dependent on autocrine production of transforming growth factor-beta.
Circulation research 1992;70(4):820-8.
1992: R S Blank; Tim C McQuinn; K C Yin; M M Thompson; K Takeyasu; R J Schwartz; Gary K Owens
Elements of the smooth muscle alpha-actin promoter required in cis for transcriptional activation in smooth muscle. Evidence for cell type-specific regulation.
The Journal of biological chemistry 1992;267(2):984-9.
1991: M B Turla; M M Thompson; M H Corjay; Gary K Owens
Mechanisms of angiotensin II- and arginine vasopressin-induced increases in protein synthesis and content in cultured rat aortic smooth muscle cells. Evidence for selective increases in smooth muscle isoactin expression.
Circulation research 1991;68(1):288-99.
1991: Gary K Owens
Role of contractile agonists in growth regulation of vascular smooth muscle cells.
Advances in experimental medicine and biology 1991;308():71-9.
1990: M H Corjay; R S Blank; Gary K Owens
Platelet-derived growth factor-induced destabilization of smooth muscle alpha-actin mRNA.
Journal of cellular physiology 1990;145(3):391-7.
1990: R S Blank; Gary K Owens
Platelet-derived growth factor regulates actin isoform expression and growth state in cultured rat aortic smooth muscle cells.
Journal of cellular physiology 1990;142(3):635-42.
1989: Gary K Owens
Control of hypertrophic versus hyperplastic growth of vascular smooth muscle cells.
The American journal of physiology 1989;257(6 Pt 2):H1755-65.
1989: A A Geisterfer; Gary K Owens
Arginine vasopressin-induced hypertrophy of cultured rat aortic smooth muscle cells.
Hypertension 1989;14(4):413-20.
1989: M H Corjay; M M Thompson; Kevin R Lynch; Gary K Owens
Differential effect of platelet-derived growth factor- versus serum-induced growth on smooth muscle alpha-actin and nonmuscle beta-actin mRNA expression in cultured rat aortic smooth muscle cells.
The Journal of biological chemistry 1989;264(18):10501-6.
1988: Gary K Owens; A A Geisterfer; Y W Yang; A Komoriya
Transforming growth factor-beta-induced growth inhibition and cellular hypertrophy in cultured vascular smooth muscle cells.
The Journal of cell biology 1988;107(2):771-80.
1988: R S Blank; M M Thompson; Gary K Owens
Cell cycle versus density dependence of smooth muscle alpha actin expression in cultured rat aortic smooth muscle cells.
The Journal of cell biology 1988;107(1):299-306.
1988: A A Geisterfer; M J Peach; Gary K Owens
Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells.
Circulation research 1988;62(4):749-56.
1988: Gary K Owens; S M Schwartz; M McCanna
Evaluation of medial hypertrophy in resistance vessels of spontaneously hypertensive rats.
Hypertension 1988;11(2):198-207.