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Ida Owens

Research Profile

Chemicals & Drugs

Disorders

Crigler-Najjar Syndrome

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Physiology

Anatomy

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Amino Acid Sequences

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Cloning, Molecular

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Publications

TOP 3
Sunit K Chakraborty; Sirsendu Jana; Mousumi Basu; Nikhil K Basu; Amit Raychoudhuri; Ida S Owens
Protein kinase Cα and Src kinase support human prostate-distributed dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 activity.
Partha S Mitra; Nikhil K Basu; Mousumi Basu; Sunit Chakraborty; Tapas Saha; Ida S Owens
Regulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.
Partha S Mitra; Nikhil K Basu; Ida S Owens
Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.

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2012: Sunit K Chakraborty; Sirsendu Jana; Mousumi Basu; Nikhil K Basu; Amit Raychoudhuri; Ida S Owens
Protein kinase Cα and Src kinase support human prostate-distributed dihydrotestosterone-metabolizing UDP-glucuronosyltransferase 2B15 activity.
The Journal of biological chemistry 2012;287(29):24387-96.
2011: Partha S Mitra; Nikhil K Basu; Mousumi Basu; Sunit Chakraborty; Tapas Saha; Ida S Owens
Regulated phosphorylation of a major UDP-glucuronosyltransferase isozyme by tyrosine kinases dictates endogenous substrate selection for detoxification.
The Journal of biological chemistry 2011;286(2):1639-48.
2009: Partha S Mitra; Nikhil K Basu; Ida S Owens
Src supports UDP-glucuronosyltransferase-2B7 detoxification of catechol estrogens associated with breast cancer.
Biochemical and biophysical research communications 2009;382(4):651-6.
2008: Nikhil K Basu; Labanyamoy Kole; Mousumi Basu; Kushal Chakraborty; Partha S Mitra; Ida S Owens
The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C.
The Journal of biological chemistry 2008;283(34):23048-61.
2008: Rajat Banerjee; Matthew W Pennington; Amanda Garza; Ida S Owens
Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence.
Biochemistry 2008;47(28):7385-92.
2007: Nikhil K Basu; Labanyamoy Kole; Mousumi Basu; Antony F McDonagh; Ida S Owens
Targeted inhibition of glucuronidation markedly improves drug efficacy in mice - a model.
Biochemical and biophysical research communications 2007;360(1):7-13.
2005: Peter I Mackenzie; Karl Walter Bock; Brian Burchell; Chantal Guillemette; Shin-ichi Ikushiro; Takashi Iyanagi; John O Miners; Ida S Owens; Daniel W Nebert
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily.
Pharmacogenetics and genomics 2005;15(10):677-85.
2005: Nikhil K Basu; Martina Kovarova; Amanda Garza; Shigeki Kubota; Tapas Saha; Partha S Mitra; Rajat Banerjee; Juan Rivera; Ida S Owens
Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(18):6285-90.
2005: Ida S Owens; Nikhil K Basu; Rajat Banerjee
UDP-glucuronosyltransferases: gene structures of UGT1 and UGT2 families.
Methods in enzymology 2005;400():1-22.
2004: Nikhil K Basu; Shigeki Kubota; Meselhy R Meselhy; Marco Ciotti; Bhabadeb Chowdhury; Masao Hartori; Ida S Owens
Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.
The Journal of biological chemistry 2004;279(27):28320-9.
2004: Nikhil K Basu; Labanyamoy Kole; Shigeki Kubota; Ida S Owens
Human UDP-glucuronosyltransferases show atypical metabolism of mycophenolic acid and inhibition by curcumin.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(7):768-73.
2004: Nikhil K Basu; Marco Ciotti; Myung S Hwang; Labanyamoy Kole; Partha S Mitra; Jeong W Cho; Ida S Owens
Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.
The Journal of biological chemistry 2004;279(2):1429-41.
2003: Nikhil K Basu; Labanyamoy Kole; Ida S Owens
Evidence for phosphorylation requirement for human bilirubin UDP-glucuronosyltransferase (UGT1A1) activity.
Biochemical and biophysical research communications 2003;303(1):98-104.
2001: Q H Gong; Jeong W Cho; T Huang; C Potter; N Gholami; Nikhil K Basu; Shigeki Kubota; S Carvalho; M W Pennington; Ida S Owens; N C Popescu
Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.
Pharmacogenetics 2001;11(4):357-68.
2001: Junko Sugatani; H Kojima; Akiko Ueda; Satoru Kakizaki; Kouichi Yoshinari; Q H Gong; Ida S Owens; Masahiko Negishi; Tatsuya Sueyoshi
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.
Hepatology (Baltimore, Md.) 2001;33(5):1232-8.
1999: Marco Ciotti; Vijaya M Lakshmi; Nikhil K Basu; Bernard B Davis; Ida S Owens; Terry V Zenser
Glucuronidation of benzidine and its metabolites by cDNA-expressed human UDP-glucuronosyltransferases and pH stability of glucuronides.
Carcinogenesis 1999;20(10):1963-9.
1999: Marco Ciotti; Nikhil K Basu; M Brangi; Ida S Owens
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus.
Biochemical and biophysical research communications 1999;260(1):199-202.
1999: Marco Ciotti; S L Werlin; Ida S Owens
Delayed response to phenobarbital treatment of a Crigler-Najjar type II patient with partially inactivating missense mutations in the bilirubin UDP-glucuronosyltransferase gene.
Journal of pediatric gastroenterology and nutrition 1999;28(2):210-3.
1998: Marco Ciotti; Jeong W Cho; J George; Ida S Owens
Required buried alpha-helical structure in the bilirubin UDP-glucuronosyltransferase, UGT1A1, contains a nonreplaceable phenylalanine.
Biochemistry 1998;37(31):11018-25.
1998: Marco Ciotti; F Chen; Firmino Francesco Rubaltelli; Ida S Owens
Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler-Najjar type I disease.
Biochimica et biophysica acta 1998;1407(1):40-50.
1997: Marco Ciotti; A Marrone; C Potter; Ida S Owens
Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications.
Pharmacogenetics 1997;7(6):485-95.
1997: Peter I Mackenzie; Ida S Owens; Brian Burchell; Karl Walter Bock; Amos Bairoch; A Bélanger; Sylvie Fournel-Gigleux; M Green; Dean W Hum; Takashi Iyanagi; D Lancet; P Louisot; Jacques Magdalou; Jayanta Roy-Chowdhury; Joseph K Ritter; H Schachter; Thomas R Tephly; K F Tipton; Daniel W Nebert
The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.
Pharmacogenetics 1997;7(4):255-69.
1997: Marco Ciotti; R Obaray; M G Martín; Ida S Owens
Genetic defects at the UGT1 locus associated with Crigler-Najjar type I disease, including a prenatal diagnosis.
American journal of medical genetics 1997;68(2):173-8.
1996: Ida S Owens; J K Ritter; M T Yeatman; F Chen
The novel UGT1 gene complex links bilirubin, xenobiotics, and therapeutic drug metabolism by encoding UDP-glucuronosyltransferase isozymes with a common carboxyl terminus.
Journal of pharmacokinetics and biopharmaceutics 1996;24(5):491-508.
1996: Marco Ciotti; Ida S Owens
Evidence for overlapping active sites for 17 alpha-ethynlestradiol and bilirubin in the human major bilirubin UDPglucuronosyltransferase.
Biochemistry 1996;35(31):10119-24.
1996: F Chen; J Zhou; J K Ritter; C A Bondy; Ida S Owens
Lobular distribution of human liver phenol and bilirubin uridine 5'-diphosphate glucuronosyltransferase messenger RNAs.
Gastroenterology 1996;111(2):472-80.
1995: Marco Ciotti; M T Yeatman; R J Sokol; Ida S Owens
Altered coding for a strictly conserved di-glycine in the major bilirubin UDP-glucuronosyltransferase of a Crigler-Najjar type I patient.
The Journal of biological chemistry 1995;270(7):3284-91.
1995: Ida S Owens; J K Ritter
Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation.
Progress in nucleic acid research and molecular biology 1995;51():305-38.
1994: S R Babu; Vijaya M Lakshmi; Ida S Owens; Terry V Zenser; Bernard B Davis
Human liver glucuronidation of benzidine.
Carcinogenesis 1994;15(9):2003-7.
1994: L T Erps; J K Ritter; J H Hersh; D Blossom; N C Martin; Ida S Owens
Identification of two single base substitutions in the UGT1 gene locus which abolish bilirubin uridine diphosphate glucuronosyltransferase activity in vitro.
The Journal of clinical investigation 1994;93(2):564-70.
1993: J K Ritter; M T Yeatman; C Kaiser; Bruno Gridelli; Ida S Owens
A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type I patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase.
The Journal of biological chemistry 1993;268(31):23573-9.
1993: F Chen; J K Ritter; M G Wang; O W McBride; R A Lubet; Ida S Owens
Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms.
Biochemistry 1993;32(40):10648-57.
1992: J K Ritter; M T Yeatman; P Ferreira; Ida S Owens
Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient.
The Journal of clinical investigation 1992;90(1):150-5.
1992: Ida S Owens; J K Ritter
The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes.
Pharmacogenetics 1992;2(3):93-108.
1992: J K Ritter; F Chen; Y Y Sheen; R A Lubet; Ida S Owens
Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives.
Biochemistry 1992;31(13):3409-14.
1992: J K Ritter; F Chen; Y Y Sheen; H M Tran; S Kimura; M T Yeatman; Ida S Owens
A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.
The Journal of biological chemistry 1992;267(5):3257-61.
1991: J K Ritter; Ida S Owens; M Negishi; K Nagata; Y Y Sheen; J R Gillette; H A Sasame
Mouse pulmonary cytochrome P-450 naphthalene hydroxylase: cDNA cloning, sequence, and expression in Saccharomyces cerevisiae.
Biochemistry 1991;30(48):11430-7.
1991: J K Ritter; J M Crawford; Ida S Owens
Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells.
The Journal of biological chemistry 1991;266(2):1043-7.
1990: J K Ritter; Y Y Sheen; Ida S Owens
Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-catechol estrogens and estriol as primary substrates.
The Journal of biological chemistry 1990;265(14):7900-6.
1990: F Toghrol; T Kimura; Ida S Owens
Expression of UDP-glucuronosyltransferase cDNA in Saccharomyces cerevisiae as a membrane-bound and as a cytosolic form.
Biochemistry 1990;29(9):2349-56.
1987: T Kimura; Ida S Owens
Mouse UDP glucuronosyltransferase. cDNA and complete amino acid sequence and regulation.
European journal of biochemistry / FEBS 1987;168(3):515-21.
1985: Peter I Mackenzie; M M Joffe; P J Munson; Ida S Owens
Separation of different UDP glucuronosyltransferase activities according to charge heterogeneity by chromatofocusing using mouse liver microsomes. Three major types of aglycones.
Biochemical pharmacology 1985;34(6):737-46.
1984: Peter I Mackenzie; F J Gonzalez; Ida S Owens
Cloning and characterization of DNA complementary to rat liver UDP-glucuronosyltransferase mRNA.
The Journal of biological chemistry 1984;259(19):12153-60.
1984: Peter I Mackenzie; Ida S Owens
Cleavage of nascent UDP glucuronosyltransferase from rat liver by dog pancreatic microsomes.
Biochemical and biophysical research communications 1984;122(3):1441-9.
1984: Peter I Mackenzie; Leonard M Hjelmeland; Ida S Owens
Purification and immunochemical characterization of a low-pI form of UDP glucuronosyltransferase from mouse liver.
Archives of biochemistry and biophysics 1984;231(2):487-97.
1984: Peter I Mackenzie; F J Gonzalez; Ida S Owens
Cell-free translation of mouse liver mRNA coding for two forms of UDP glucuronosyltransferase.
Archives of biochemistry and biophysics 1984;230(2):676-80.
1984: Ida S Owens; Peter I Mackenzie
Differential induction and glycosylation of UDP-glucuronosyltransferase.
Biochemical Society transactions 1984;12(1):54-5.
1984: Peter I Mackenzie; M A Lang; Ida S Owens
Effect of different detergent systems on the molecular size of UDP glucuronosyltransferase and other microsomal drug-metabolizing enzymes.
Membrane biochemistry 1984;5(3):193-207.
1983: Peter I Mackenzie; Ida S Owens
Differences in UDP-glucuronosyltransferase activities in congenic inbred rats homozygous and heterozygous for the jaundice locus.
Biochemical pharmacology 1983;32(24):3777-81.
1983: Peter I Mackenzie; Ida S Owens
Purification of a form of mouse liver UDP glucuronosyltransferase which glucuronidates androgens.
Journal of steroid biochemistry 1983;19(2):1097-102.
1982: Ida S Owens; Peter I Mackenzie
A comparison of the isoelectric points of mouse liver UDP-glucuronosyltransferase enzymes conjugating the twelve benzo[a]pyrene phenols.
Biochemical and biophysical research communications 1982;109(4):1075-82.