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George Aghajanian

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TOP 3
Ronald S Duman; George K Aghajanian
Synaptic dysfunction in depression: potential therapeutic targets.
Rong-Jian Liu; Francis Bambico; Ronald S Duman; Francis S Lee; Xiao-Yuan Li; George K Aghajanian
Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex.
Robert M Sears; Rong-Jian Liu; Nandakumar Narayanan; Ruth Sharf; Mark F Yeckel; Mark Laubach; George K Aghajanian; Ralph J DiLeone
Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone.

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All Publications

2012: Ronald S Duman; George K Aghajanian
Synaptic dysfunction in depression: potential therapeutic targets.
Science (New York, N.Y.) 2012;338(6103):68-72.
2012: Rong-Jian Liu; Francis Bambico; Ronald S Duman; Francis S Lee; Xiao-Yuan Li; George K Aghajanian
Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex.
Biological psychiatry 2012;71(11):996-1005.
2010: Robert M Sears; Rong-Jian Liu; Nandakumar Narayanan; Ruth Sharf; Mark F Yeckel; Mark Laubach; George K Aghajanian; Ralph J DiLeone
Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(24):8263-73.
2009: George K Aghajanian
Modeling "psychosis" in vitro by inducing disordered neuronal network activity in cortical brain slices.
Psychopharmacology 2009;206(4):575-85.
2008: Rong-Jian Liu; George K Aghajanian
Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(1):359-64.
2007: Evelyn K Lambe; Rong-Jian Liu; George K Aghajanian
Schizophrenia, hypocretin (orexin), and the thalamocortical activating system.
Schizophrenia bulletin 2007;33(6):1284-90.
2007: Evelyn K Lambe; George K Aghajanian
Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation.
Neuroscience 2007;145(3):900-10.
2006: Evelyn K Lambe; George K Aghajanian
Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006;31(8):1682-9.
2006: Ming-Hu Han; Carlos A Bolaños; Thomas A Green; Valerie G Olson; Rachael L Neve; Rong-Jian Liu; George K Aghajanian; Eric J Nestler
Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4624-9.
2006: Maribel Rios; Evelyn K Lambe; Rongjian Liu; Sarah Teillon; JinHong Liu; Schahram Akbarian; Suzanne Roffler-Tarlov; Rudolf Jaenisch; George K Aghajanian
Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.
Journal of neurobiology 2006;66(4):408-20.
2005: Evelyn K Lambe; Peter Olausson; Nicole K Horst; Jane R Taylor; George K Aghajanian
Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(21):5225-9.
2005: Rong-Jian Liu; Evelyn K Lambe; George K Aghajanian
Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases.
The European journal of neuroscience 2005;21(4):945-58.
2003: Evelyn K Lambe; George K Aghajanian
Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice.
Neuron 2003;40(1):139-50.
2003: Stephen J Gold; Ming-Hu Han; Amy E Herman; Yan G Ni; Cindy M Pudiak; George K Aghajanian; Rong-Jian Liu; Bryan W Potts; Susanne M Mumby; Eric J Nestler
Regulation of RGS proteins by chronic morphine in rat locus coeruleus.
The European journal of neuroscience 2003;17(5):971-80.
2003: Evelyn K Lambe; Marina R Picciotto; George K Aghajanian
Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2003;28(2):216-25.
2002: Rong-Jian Liu; Anthony N van den Pol; George K Aghajanian
Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(21):9453-64.
2002: Rongjian Liu; Yuqiang Ding; George K Aghajanian
Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2002;27(3):329-40.
2002: Schahram Akbarian; Maribel Rios; Rong-Jian Liu; Stephen J Gold; Hiu-Fai Fong; Steven R Zeiler; Vincenzo Coppola; Lino Tessarollo; Kevin R Jones; Eric J Nestler; George K Aghajanian; Rudolf Jaenisch
Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(10):4153-62.
2002: Anthony N van den Pol; Prabhat K Ghosh; Rong-Jian Liu; Ying Li; George K Aghajanian; Xiao-Bing Gao
Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus.
The Journal of physiology 2002;541(Pt 1):169-85.
2001: Evelyn K Lambe; George K Aghajanian
The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(24):9955-63.
2001: Schahram Akbarian; Brian Bates; Rong-Jian Liu; S L Skirboll; T Pejchal; Vincenzo Coppola; L D Sun; G Fan; Jan Kucera; M A Wilson; Lino Tessarollo; Barry E Kosofsky; J R Taylor; Mark Bothwell; Eric J Nestler; George K Aghajanian; Rudolf Jaenisch
Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal.
Molecular psychiatry 2001;6(5):593-604.
2001: Grace E Stutzmann; Gerard Marek; George K Aghajanian
Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex.
Neuroscience 2001;105(1):55-69.
2000: Evelyn K Lambe; Patricia S Goldman-Rakic; George K Aghajanian
Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat.
Cerebral cortex (New York, N.Y. : 1991) 2000;10(10):974-80.
2000: R Liu; T Jolas; George K Aghajanian
Serotonin 5-HT(2) receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus.
Brain research 2000;873(1):34-45.
2000: M Teresa Abellán; T Jolas; George K Aghajanian; Francesc Artigas
Dual control of dorsal raphe serotonergic neurons by GABA(B) receptors. Electrophysiological and microdialysis studies.
Synapse (New York, N.Y.) 2000;36(1):21-34.
2000: George K Aghajanian; Gerard Marek
Serotonin model of schizophrenia: emerging role of glutamate mechanisms.
Brain research. Brain research reviews 2000;31(2-3):302-12.
2000: T Jolas; Eric J Nestler; George K Aghajanian
Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway.
Neuroscience 2000;95(2):433-43.
2000: Gerard Marek; Rebecca A Wright; Darryle D Schoepp; James A Monn; George K Aghajanian
Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.
The Journal of pharmacology and experimental therapeutics 2000;292(1):76-87.
1999: Eric J Nestler; Meenakshi Alreja; George K Aghajanian
Molecular control of locus coeruleus neurotransmission.
Biological psychiatry 1999;46(9):1131-9.
1999: George K Aghajanian; Gerard Marek
Serotonin and hallucinogens.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1999;21(2 Suppl):16S-23S.
1999: George K Aghajanian; Gerard Marek
Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release.
Brain research 1999;825(1-2):161-71.
1999: Gerard Marek; George K Aghajanian
5-HT2A receptor or alpha1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex.
European journal of pharmacology 1999;367(2-3):197-206.
1998: Gerard Marek; George K Aghajanian
The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis.
Biological psychiatry 1998;44(11):1118-27.
1998: Gerard Marek; George K Aghajanian
5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by mu-opiate receptor activation.
Neuroscience 1998;86(2):485-97.
1998: Gerard Marek; George K Aghajanian
Indoleamine and the phenethylamine hallucinogens: mechanisms of psychotomimetic action.
Drug and alcohol dependence 1998;51(1-2):189-98.
1997: SB Lane-Ladd; J Pineda; VA Boundy; T Pfeuffer; J Krupinski; George K Aghajanian; Eric J Nestler
CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(20):7890-901.
1997: Eric J Nestler; George K Aghajanian
Molecular and cellular basis of addiction.
Science (New York, N.Y.) 1997;278(5335):58-63.
1997: T Jolas; George K Aghajanian
Neurotensin and the serotonergic system.
Progress in neurobiology 1997;52(6):455-68.
1997: T Jolas; George K Aghajanian
Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro.
Brain research 1997;755(2):229-45.
1997: VA Vaidya; Gerard Marek; George K Aghajanian; Ronald S Duman
5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(8):2785-95.
1997: George K Aghajanian; Gerard Marek
Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells.
Neuropharmacology 1997;36(4-5):589-99.
1997: J Pineda; George K Aghajanian
Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current.
Neuroscience 1997;77(3):723-43.
1997: Anissa Abi-Dargham; Marc Laruelle; George K Aghajanian; Dennis Charney; John H Krystal
The role of serotonin in the pathophysiology and treatment of schizophrenia.
The Journal of neuropsychiatry and clinical neurosciences 1997;9(1):1-17.
1996: Gerard Marek; George K Aghajanian
LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex.
The Journal of pharmacology and experimental therapeutics 1996;278(3):1373-82.
1996: Gerard Marek; George K Aghajanian
Alpha 1B-adrenoceptor-mediated excitation of piriform cortical interneurons.
European journal of pharmacology 1996;305(1-3):95-100.
1996: J Pineda; J H Kogan; George K Aghajanian
Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(4):1389-99.
1996: T Jolas; George K Aghajanian
Neurotensin excitation of serotonergic neurons in the dorsal raphe nucleus of the rat in vitro.
The European journal of neuroscience 1996;8(1):153-61.
1995: Gerard Marek; George K Aghajanian
Protein kinase C inhibitors enhance the 5-HT2A receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex.
Synapse (New York, N.Y.) 1995;21(2):123-30.
1995: J H Kogan; George K Aghajanian
Long-term glutamate desensitization in locus coeruleus neurons and its role in opiate withdrawal.
Brain research 1995;689(1):111-21.
1995: Meenakshi Alreja; George K Aghajanian
Use of the whole-cell patch-clamp method in studies on the role of cAMP in regulating the spontaneous firing of locus coeruleus neurons.
Journal of neuroscience methods 1995;59(1):67-75.
1994: R N Iyer; J S Sprouse; George K Aghajanian; Robert H Roth; Charles W Bradberry
Tryptophan pretreatment augmentation of p-chloroamphetamine-induced serotonin and dopamine release and reduction of long-term neurotoxicity.
Biochemical pharmacology 1994;48(7):1501-8.
1994: Gerard Marek; George K Aghajanian
Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist.
European journal of pharmacology 1994;259(2):137-41.
1994: Meenakshi Alreja; George K Aghajanian
QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons.
Brain research 1994;639(2):320-4.
1994: George K Aghajanian; J H Kogan; B Moghaddam
Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study.
Brain research 1994;636(1):126-30.
1994: R L Gellman; George K Aghajanian
Serotonin2 receptor-mediated excitation of interneurons in piriform cortex: antagonism by atypical antipsychotic drugs.
Neuroscience 1994;58(3):515-25.
1994: George K Aghajanian
Electrophysiological studies on the actions of hallucinogenic drugs at 5-HT2 receptors in rat brain.
NIDA research monograph 1994;146():183-202.
1994: Eric J Nestler; Meenakshi Alreja; George K Aghajanian
Molecular and cellular mechanisms of opiate action: studies in the rat locus coeruleus.
Brain research bulletin 1994;35(5-6):521-8.
1993: Meenakshi Alreja; George K Aghajanian
Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus coeruleus neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(8):3525-32.
1993: X Guitart; J H Kogan; M Berhow; Rose Terwilliger; George K Aghajanian; Eric J Nestler
Lewis and Fischer rat strains display differences in biochemical, electrophysiological and behavioral parameters: studies in the nucleus accumbens and locus coeruleus of drug naive and morphine-treated animals.
Brain research 1993;611(1):7-17.
1993: J C Garratt; Meenakshi Alreja; George K Aghajanian
LSD has high efficacy relative to serotonin in enhancing the cationic current Ih: intracellular studies in rat facial motoneurons.
Synapse (New York, N.Y.) 1993;13(2):123-34.
1993: R L Gellman; George K Aghajanian
Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons.
Brain research 1993;600(1):63-73.
1992: J H Kogan; Eric J Nestler; George K Aghajanian
Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats.
European journal of pharmacology 1992;211(1):47-53.
1992: George K Aghajanian; Meenakshi Alreja; Eric J Nestler; J H Kogan
Dual mechanisms of opiate dependence in the locus coeruleus.
Clinical neuropharmacology 1992;15 Suppl 1 Pt A():143A-144A.
1991: Meenakshi Alreja; George K Aghajanian
Activation of locus coeruleus (LC) neurones by cholera toxin: mediation by cAMP-dependent protein kinase.
Neuroscience letters 1991;134(1):113-7.
1991: P W Sheldon; George K Aghajanian
Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons.
Synapse (New York, N.Y.) 1991;9(3):208-18.
1991: Meenakshi Alreja; George K Aghajanian
Pacemaker activity of locus coeruleus neurons: whole-cell recordings in brain slices show dependence on cAMP and protein kinase A.
Brain research 1991;556(2):339-43.
1991: Charles W Bradberry; J S Sprouse; George K Aghajanian; Robert H Roth
Sub-picogram determination of serotonin using HPLC with electrochemical detection for microdialysis studies of serotonin release.
Advances in experimental medicine and biology 1991;294():81-9.
1991: Charles W Bradberry; J S Sprouse; P W Sheldon; George K Aghajanian; Robert H Roth
In vitro microdialysis: a novel technique for stimulated neurotransmitter release measurements.
Journal of neuroscience methods 1991;36(1):85-90.
1990: Yanyan Wang; George K Aghajanian
Excitation of locus coeruleus neurons by vasoactive intestinal peptide: role of a cAMP and protein kinase A.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(10):3335-43.
1990: George K Aghajanian
Serotonin-induced inward current in rat facial motoneurons: evidence for mediation by G proteins but not protein kinase C.
Brain research 1990;524(1):171-4.
1990: K Rasmussen; D B Beitner-Johnson; John H Krystal; George K Aghajanian; Eric J Nestler
Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(7):2308-17.
1990: J S Sprouse; Charles W Bradberry; Robert H Roth; George K Aghajanian
3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by L-tryptophan.
European journal of pharmacology 1990;178(3):313-20.
1990: Charles W Bradberry; J S Sprouse; George K Aghajanian; Robert H Roth
3,4-methylenedioxymethamphetamine (MDMA)-induced release of endogenous serotonin from the rat dorsal raphe nucleus in vitro: Effects of fluoxetine and tryptophan.
Neurochemistry international 1990;17(4):509-13.
1990: K Rasmussen; George K Aghajanian
Serotonin excitation of facial motoneurons: receptor subtype characterization.
Synapse (New York, N.Y.) 1990;5(4):324-32.
1990: George K Aghajanian; J S Sprouse; P Sheldon; K Rasmussen
Electrophysiology of the central serotonin system: receptor subtypes and transducer mechanisms.
Annals of the New York Academy of Sciences 1990;600():93-103; discussion 103.
1990: P W Sheldon; George K Aghajanian
Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2-activated interneuron.
Brain research 1990;506(1):62-9.
1989: K Rasmussen; George K Aghajanian
Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis.
Brain research 1989;505(2):346-50.
1989: Yanyan Wang; George K Aghajanian
Excitation of locus coeruleus neurons by vasoactive intestinal peptide: evidence for a G-protein-mediated inward current.
Brain research 1989;500(1-2):107-18.
1989: J S Sprouse; Charles W Bradberry; Robert H Roth; George K Aghajanian
MDMA (3,4-methylenedioxymethamphetamine) inhibits the firing of dorsal raphe neurons in brain slices via release of serotonin.
European journal of pharmacology 1989;167(3):375-83.
1989: K Rasmussen; George K Aghajanian
Failure to block responses of locus coeruleus neurons to somatosensory stimuli by destruction of two major afferent nuclei.
Synapse (New York, N.Y.) 1989;4(2):162-4.
1989: George K Aghajanian; K Rasmussen
Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices.
Synapse (New York, N.Y.) 1989;3(4):331-8.
1988: Robert B Innis; Eric J Nestler; George K Aghajanian
Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons.
Brain research 1988;459(1):27-36.
1988: J S Sprouse; George K Aghajanian
Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons.
Neuropharmacology 1988;27(7):707-15.
1988: K Rasmussen; George K Aghajanian
Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1988;1(2):101-7.
1987: Yanyan Wang; George K Aghajanian
Intracellular GTP gamma S restores the ability of morphine to hyperpolarize rat locus coeruleus neurons after blockade by pertussis toxin.
Brain research 1987;436(2):396-401.
1987: J E Freedman; George K Aghajanian
Role of phosphoinositide metabolites in the prolongation of afterhyperpolarizations by alpha 1-adrenoceptors in rat dorsal raphe neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(12):3897-906.
1987: Robert B Innis; George K Aghajanian
Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons.
European journal of pharmacology 1987;143(2):195-204.
1987: George K Aghajanian; Yanyan Wang
Common alpha 2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices.
Neuropharmacology 1987;26(7B):793-9.
1987: J S Sprouse; George K Aghajanian
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists.
Synapse (New York, N.Y.) 1987;1(1):3-9.
1987: T M Burlhis; George K Aghajanian
Pacemaker potentials of serotonergic dorsal raphe neurons: contribution of a low-threshold Ca2+ conductance.
Synapse (New York, N.Y.) 1987;1(6):582-8.
1987: Yanyan Wang; George K Aghajanian
Excitation of locus coeruleus neurons by an adenosine 3',5'-cyclic monophosphate-activated inward current: extracellular and intracellular studies in rat brain slices.
Synapse (New York, N.Y.) 1987;1(5):481-7.