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Cecil Pace-Asciak

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Cecil R Pace-Asciak
The hepoxilins and some analogues: a review of their biology.
Olivier Aprikian; Denis Reynaud; Cecil R Pace-Asciak; Patricia Leone; Florence Blancher; Irina Monnard; Christian Darimont; Katherine Macé
Neonatal dietary supplementation of arachidonic acid increases prostaglandin levels in adipose tissue but does not promote fat mass development in guinea pigs.
Jonathan D Steels; Mathew P Estey; Carol D Froese; Denis Reynaud; Cecil R Pace-Asciak; William S Trimble
Sept12 is a component of the mammalian sperm tail annulus.

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All Publications

2009: Cecil R Pace-Asciak
The hepoxilins and some analogues: a review of their biology.
British journal of pharmacology 2009;158(4):972-81.
2007: Olivier Aprikian; Denis Reynaud; Cecil R Pace-Asciak; Patricia Leone; Florence Blancher; Irina Monnard; Christian Darimont; Katherine Macé
Neonatal dietary supplementation of arachidonic acid increases prostaglandin levels in adipose tissue but does not promote fat mass development in guinea pigs.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(5):R2006-12.
2007: Jonathan D Steels; Mathew P Estey; Carol D Froese; Denis Reynaud; Cecil R Pace-Asciak; William S Trimble
Sept12 is a component of the mammalian sperm tail annulus.
Cell motility and the cytoskeleton 2007;64(10):794-807.
2007: Na Qiao; Denis Reynaud; Mohamed Abdelhaleem; Cecil R Pace-Asciak
Hepoxilin analogs, PBT-3 and PBT-4, cause apoptosis of Gleevec-resistant K562 cells in vitro.
In vivo (Athens, Greece) 2007;21(2):267-71.
2006: Ian B Copland; Denis Reynaud; Cecil R Pace-Asciak; Martin Post
Mechanotransduction of stretch-induced prostanoid release by fetal lung epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L487-95.
2006: Yi-Wei Huang; Mark C Surka; Denis Reynaud; Cecil R Pace-Asciak; William S Trimble
GTP binding and hydrolysis kinetics of human septin 2.
The FEBS journal 2006;273(14):3248-60.
2006: Julien Hanson; Denis Reynaud; Na Qiao; Philippe Devel; Anne-Lise Moray; Jean-François Renard; Leanne P Kelley; Jean-Yves Winum; Jean-Louis Montero; B Therese Kinsella; Bernard Pirotte; Cecil R Pace-Asciak; Jean-Michel Dogné
Synthesis and pharmacological evaluation of novel nitrobenzenic thromboxane modulators as antiplatelet agents acting on both the alpha and beta isoforms of the human thromboxane receptor.
Journal of medicinal chemistry 2006;49(12):3701-9.
2006: Cecil R Pace-Asciak; Xiang Li; Na Qiao; Denis Reynaud; Peter Demin; Mohamed Abdelhaleem
Hepoxilin analogs, potential new therapeutics in disease.
Current pharmaceutical design 2006;12(8):963-9.
2006: Jean-Michel Dogné; Julien Hanson; Xavier de Leval; Domenico Pratico'; Cecil R Pace-Asciak; Pierre Drion; Bernard Pirotte; Ke-He Ruan
From the design to the clinical application of thromboxane modulators.
Current pharmaceutical design 2006;12(8):903-23.
2005: Xiang Li; Na Qiao; Denis Reynaud; Mohamed Abdelhaleem; Cecil R Pace-Asciak
PBT-3, a hepoxilin stable analog, causes long term inhibition of growth of K562 solid tumours in vivo.
Biochemical and biophysical research communications 2005;338(1):158-60.
2005: Michelle Duggan; Patrick J McNamara; Doreen Engelberts; Cecil R Pace-Asciak; Paul Babyn; Martin Post; Brian P Kavanagh
Oxygen attenuates atelectasis-induced injury in the in vivo rat lung.
Anesthesiology 2005;103(3):522-31.
2005: Cecil R Pace-Asciak
Novel eicosanoid pathways: the discovery of prostacyclin/6-keto prostaglandin F1alpha and the hepoxilins.
Molecular neurobiology 2005;32(1):19-26.
2005: Julien Hanson; Stéphanie Rolin; Denis Reynaud; Na Qiao; Leanne P Kelley; Helen M Reid; François Valentin; John R Tippins; B Therese Kinsella; Bernard Masereel; Cecil R Pace-Asciak; Bernard Pirotte; Jean-Michel Dogné
In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2005;313(1):293-301.
2005: Xiang Li; Na Qiao; Denis Reynaud; Mohamed Abdelhaleem; Cecil R Pace-Asciak
The hepoxilin analog, PBT-3, inhibits growth of K-562 CML solid tumours in vivo in nude mice.
In vivo (Athens, Greece) 2005;19(1):185-9.
2003: Na Qiao; Denis Reynaud; Peter Demin; Perry V Halushka; Cecil R Pace-Asciak
The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPalpha isoform in transfected COS-7 cells.
The Journal of pharmacology and experimental therapeutics 2003;307(3):1142-7.
2003: Jaques Belik; Robert P Jankov; Jingyi Pan; Man Yi; Cecil R Pace-Asciak; A Keith Tanswell
Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium.
Journal of applied physiology (Bethesda, Md. : 1985) 2003;95(5):1979-85.
2003: Na Qiao; Janice Lam; Denis Reynaud; Mohamed Abdelhaleem; Cecil R Pace-Asciak
The hepoxilin analog PBT-3 induces apoptosis in BCR-ABL-positive K562 leukemia cells.
Anticancer research 2003;23(5A):3617-22.
2003: Claire L Vogan; Ben H Maskrey; Graham W Taylor; Sheelagh Henry; Cecil R Pace-Asciak; Anthony S Clare; Andrew F Rowley
Hepoxilins and trioxilins in barnacles: an analysis of their potential roles in egg hatching and larval settlement.
The Journal of experimental biology 2003;206(Pt 18):3219-26.
2003: Denis Reynaud; Dewi Clark; Na Qiao; Margaret L Rand; Cecil R Pace-Asciak
The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100.
Thrombosis research 2003;112(4):245-8.
2003: R K Amer; Cecil R Pace-Asciak; Linda R Mills
A lipoxygenase product, hepoxilin A(3), enhances nerve growth factor-dependent neurite regeneration post-axotomy in rat superior cervical ganglion neurons in vitro.
Neuroscience 2003;116(4):935-46.
2002: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin; Rukshana Aslam; Andrea Sun
A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition.
The Journal of pharmacology and experimental therapeutics 2002;301(2):618-24.
2002: Robert P Jankov; Xiaoping Luo; Peter Demin; Rukshana Aslam; Vicky Hannam; A Keith Tanswell; Cecil R Pace-Asciak
Hepoxilin analogs inhibit bleomycin-induced pulmonary fibrosis in the mouse.
The Journal of pharmacology and experimental therapeutics 2002;301(2):435-40.
2002: Denis Reynaud; Alexander Hinek; Cecil R Pace-Asciak
The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.
FEBS letters 2002;515(1-3):58-60.
2001: Denis Reynaud; Andrea Sun; Peter Demin; Cecil R Pace-Asciak
Novel platelet antiaggregating substances.
Biochemical and biophysical research communications 2001;284(3):580-2.
1999: Cecil R Pace-Asciak; Peter Demin; M Estrada; G Liu
Hepoxilins raise circulating insulin levels in vivo.
FEBS letters 1999;461(3):165-8.
1999: M M Wang; Peter Demin; Cecil R Pace-Asciak
Stereoselective actions of hepoxilins A3 and B3 and their cyclopropane analogs (HxdeltaA3 and HxdeltaB3) on bradykinin and PAF-evoked potentiation of vascular leakage in rat skin.
General pharmacology 1999;33(5):377-82.
1999: Denis Reynaud; M Ali; Peter Demin; Cecil R Pace-Asciak
Formation of 14,15-hepoxilins of the A(3) and B(3) series through a 15-lipoxygenase and hydroperoxide isomerase present in garlic roots.
The Journal of biological chemistry 1999;274(40):28213-8.
1999: SD Milone; Cecil R Pace-Asciak; Denis Reynaud; Eduardo R Azevedo; Gary E Newton; John D Parker
Biochemical, hemodynamic, and vascular evidence concerning the free radical hypothesis of nitrate tolerance.
Journal of cardiovascular pharmacology 1999;33(5):685-90.
1999: Denis Reynaud; Peter Demin; M Sutherland; S Nigam; Cecil R Pace-Asciak
Hepoxilin signaling in intact human neutrophils: biphasic elevation of intracellular calcium by unesterified hepoxilin A3.
FEBS letters 1999;446(2-3):236-8.
1999: M M Wang; Denis Reynaud; Cecil R Pace-Asciak
In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability.
Biochimica et biophysica acta 1999;1436(3):354-62.
1999: Cecil R Pace-Asciak; Denis Reynaud; Olga Rounova; Peter Demin; K K Pivnitsky
Hepoxilin A3 is metabolized into its omega-hydroxy metabolite by human neutrophils.
Advances in experimental medicine and biology 1999;469():535-8.
1999: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin; S Nigam
The hepoxilins. A review.
Advances in experimental medicine and biology 1999;447():123-32.
1997: Denis Reynaud; Olga Rounova; Peter Demin; K K Pivnitsky; Cecil R Pace-Asciak
Hepoxilin A3 is oxidized by human neutrophils into its omega-hydroxy metabolite by an activity independent of LTB4 omega-hydroxylase.
Biochimica et biophysica acta 1997;1348(3):287-98.
1997: Denis Reynaud; Cecil R Pace-Asciak
Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates.
Biochimica et biophysica acta 1997;1346(3):305-16.
1997: Linda R Mills; Denis Reynaud; Cecil R Pace-Asciak
Hepoxilin-evoked intracellular reorganization of calcium in human neutrophils: a confocal microscopy study.
Experimental cell research 1997;230(2):337-41.
1997: Cecil R Pace-Asciak; Denis Reynaud; O Laneuville; Sergio Grinstein; S Nigam
Hepoxilin A3 inhibits agonist-evoked rise in free intracellular calcium in human neutrophils.
Advances in experimental medicine and biology 1997;400A():375-80.
1997: Denis Reynaud; Cecil R Pace-Asciak
12-HETE and 12-HPETE potently stimulate intracellular release of calcium in intact human neutrophils.
Prostaglandins, leukotrienes, and essential fatty acids 1997;56(1):9-12.
1996: David M Goldberg; V Garovic-Kocic; Eleftherios P Diamandis; Cecil R Pace-Asciak
Wine: does the colour count?
Clinica chimica acta; international journal of clinical chemistry 1996;246(1-2):183-93.
1996: Cecil R Pace-Asciak; Olga Rounova; S E Hahn; E P Diamandis; David M Goldberg
Wines and grape juices as modulators of platelet aggregation in healthy human subjects.
Clinica chimica acta; international journal of clinical chemistry 1996;246(1-2):163-82.
1996: C K Chen; Cecil R Pace-Asciak
Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta.
General pharmacology 1996;27(2):363-6.
1996: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Hepoxilin A3-specific binding in human neutrophils.
The Biochemical journal 1996;313 ( Pt 2)():537-41.
1996: M M Wang; Peter Demin; Cecil R Pace-Asciak
Epimer-specific actions of hepoxilins A3 and B3 on PAF- and bradykinin-evoked vascular permeability in the rat skin in vivo.
Advances in experimental medicine and biology 1996;416():239-41.
1996: Peter Demin; Denis Reynaud; Cecil R Pace-Asciak
Chemical synthesis and actions of 11,12-thiirano-hepoxilin A3.
Journal of lipid mediators and cell signalling 1996;13(1):63-72.
1995: Peter Demin; Denis Reynaud; Cecil R Pace-Asciak
High-performance liquid chromatographic separation of fluorescent esters of hepoxilin enantiomers on a chiral stationary phase.
Journal of chromatography. B, Biomedical applications 1995;672(2):282-9.
1995: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin
Mechanistic aspects of hepoxilin biosynthesis.
Journal of lipid mediators and cell signalling 1995;12(2-3):307-11.
1995: Peter Demin; Denis Reynaud; Cecil R Pace-Asciak
Extractive derivatization of the 12-lipoxygenase products, hepoxilins, and related compounds into fluorescent anthryl esters for their complete high-performance liquid chromatography profiling in biological systems.
Analytical biochemistry 1995;226(2):252-5.
1995: Cecil R Pace-Asciak; S Hahn; Eleftherios P Diamandis; George J Soleas; David M Goldberg
The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease.
Clinica chimica acta; international journal of clinical chemistry 1995;235(2):207-19.
1995: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Hepoxilin binding in human neutrophils.
Biochemical and biophysical research communications 1995;207(1):191-4.
1995: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin
Hepoxilins: a review on their enzymatic formation, metabolism and chemical synthesis.
Lipids 1995;30(2):107-14.
1995: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Enzymatic formation of hepoxilin A3.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():183-5.
1995: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Coupling of hepoxilin A3-specific binding with calcium-mobilizing actions in human neutrophils.
Agents and actions. Supplements 1995;45():291-6.
1994: Cecil R Pace-Asciak
Hepoxilins: a review on their cellular actions.
Biochimica et biophysica acta 1994;1215(1-2):1-8.
1994: Denis Reynaud; Peter Demin; Cecil R Pace-Asciak
Hepoxilin A3 formation in the rat pineal gland selectively utilizes (12S)-hydroperoxyeicosatetraenoic acid (HPETE), but not (12R)-HPETE.
The Journal of biological chemistry 1994;269(39):23976-80.
1994: Peter Louis Carlen; N Gurevich; L Zhang; P H Wu; Denis Reynaud; Cecil R Pace-Asciak
Formation and electrophysiological actions of the arachidonic acid metabolites, hepoxilins, at nanomolar concentrations in rat hippocampal slices.
Neuroscience 1994;58(3):493-502.
1994: Denis Reynaud; I Delton; Abdallah Gharib; Nicole Sarda; Michel Lagarde; Cecil R Pace-Asciak
Formation, metabolism, and action of hepoxilin A3 in the rat pineal gland.
Journal of neurochemistry 1994;62(1):126-33.
1993: Cecil R Pace-Asciak; Denis Reynaud; Peter Demin
Enzymatic formation of hepoxilins A3 and B3.
Biochemical and biophysical research communications 1993;197(2):869-73.
1993: O Laneuville; Denis Reynaud; Sergio Grinstein; Santosh Nigam; Cecil R Pace-Asciak
Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4.
The Biochemical journal 1993;295 ( Pt 2)():393-7.
1993: Denis Reynaud; C P Thickitt; Cecil R Pace-Asciak
Facile preparation and structural determination of monohydroxy derivatives of docosahexaenoic acid (HDoHE) by alpha-tocopherol-directed autoxidation.
Analytical biochemistry 1993;214(1):165-70.
1993: Cecil R Pace-Asciak
Hepoxilins.
General pharmacology 1993;24(4):805-10.
1992: O Laneuville; R Couture; Cecil R Pace-Asciak
Neurokinin A-induced contraction of guinea-pig isolated trachea: potentiation by hepoxilins.
British journal of pharmacology 1992;107(3):808-12.
1992: Mario A Moscarello; H Pang; Cecil R Pace-Asciak; D D Wood
The N terminus of human myelin basic protein consists of C2, C4, C6, and C8 alkyl carboxylic acids.
The Journal of biological chemistry 1992;267(14):9779-82.
1992: O Laneuville; R Couture; Cecil R Pace-Asciak
Hepoxilins sensitize blood vessels to noradrenaline--stereospecificity of action.
British journal of pharmacology 1992;105(2):297-304.
1991: Z Lin; O Laneuville; Cecil R Pace-Asciak
Hepoxilin A3 induces heat shock protein (HSP72) expression in human neutrophils.
Biochemical and biophysical research communications 1991;179(1):52-6.
1991: O Laneuville; EJ Corey; R Couture; Cecil R Pace-Asciak
Hepoxilin A3 (HxA3) is formed by the rat aorta and is metabolized into HxA3-C, a glutathione conjugate.
Biochimica et biophysica acta 1991;1084(1):60-8.
1991: O Laneuville; EJ Corey; R Couture; Cecil R Pace-Asciak
Hepoxilin A3 increases vascular permeability in the rat skin.
Eicosanoids 1991;4(2):95-7.
1991: Cecil R Pace-Asciak; O Laneuville; N Gurevich; P Wu; Peter Louis Carlen; EJ Corey
Formation of a glutathionyl-conjugate of hepoxilin A3 and its action in rat brain.
Advances in prostaglandin, thromboxane, and leukotriene research 1991;21B():731-4.
1991: Cecil R Pace-Asciak; Santosh Nigam
Hepoxilins modulate second messenger systems in the human neutrophil.
Advances in experimental medicine and biology 1991;314():133-9.
1990: Cecil R Pace-Asciak; L Wong; EJ Corey
Hepoxilin A3 blocks the release of norepinephrine from rat hippocampal slices.
Biochemical and biophysical research communications 1990;173(3):949-53.
1990: O Laneuville; M Chang; C C Reddy; EJ Corey; Cecil R Pace-Asciak
Isozyme specificity in the conversion of hepoxilin A3 (HxA3) into a glutathionyl hepoxilin (HxA3-C) by the Yb2 subunit of rat liver glutathione S-transferase.
The Journal of biological chemistry 1990;265(35):21415-8.
1990: Cecil R Pace-Asciak; O Laneuville; W G Su; EJ Corey; N Gurevich; P Wu; Peter Louis Carlen
A glutathione conjugate of hepoxilin A3: formation and action in the rat central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(8):3037-41.
1990: Sascha E Dho; Sergio Grinstein; EJ Corey; W G Su; Cecil R Pace-Asciak
Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils.
The Biochemical journal 1990;266(1):63-8.
1989: Cecil R Pace-Asciak; O Laneuville; M Chang; C C Reddy; W G Su; EJ Corey
New products in the hepoxilin pathway: isolation of 11-glutathionyl hepoxilin A3 through reaction of hepoxilin A3 with glutathione S-transferase.
Biochemical and biophysical research communications 1989;163(3):1230-4.
1989: Peter Louis Carlen; N Gurevich; P H Wu; W G Su; EJ Corey; Cecil R Pace-Asciak
Actions of arachidonic acid and hepoxilin A3 on mammalian hippocampal CA1 neurons.
Brain research 1989;497(1):171-6.
1989: Cecil R Pace-Asciak; W S Lee
Purification of hepoxilin epoxide hydrolase from rat liver.
The Journal of biological chemistry 1989;264(16):9310-3.
1989: Cecil R Pace-Asciak
One-step rapid extractive methylation of plasma nonesterified fatty acids for gas chromatographic analysis.
Journal of lipid research 1989;30(3):451-4.
1989: Cecil R Pace-Asciak; S Asotra; L Pellerin; L S Wolfe; EJ Corey; P Wu; N Gurevich; Peter Louis Carlen
Brain hepoxilins: formation and action.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;19():141-7.
1989: Cecil R Pace-Asciak
Mass spectra of prostaglandins and related products.
Advances in prostaglandin, thromboxane, and leukotriene research 1989;18():1-565.
1989: Cecil R Pace-Asciak; S Asotra
Biosynthesis, catabolism, and biological properties of HPETEs, hydroperoxide derivatives of arachidonic acid.
Free radical biology & medicine 1989;7(4):409-33.
1988: Cecil R Pace-Asciak; J M Martin; S P Lee
Appearance of prostaglandins, thromboxane B2, and hepoxilin A3 in the circulation of the normal and diabetic (BB) rat after arachidonic acid administration--correlation with plasma insulin.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1988;66(8):901-9.
1988: Cecil R Pace-Asciak
Formation and metabolism of hepoxilin A3 by the rat brain.
Biochemical and biophysical research communications 1988;151(1):493-8.
1987: Cecil R Pace-Asciak; S P Lee; J M Martin
In vivo formation of hepoxilin A3 in the rat.
Biochemical and biophysical research communications 1987;147(3):881-4.
1986: Cecil R Pace-Asciak; J M Martin; EJ Corey
Hepoxilins, potential endogenous mediators of insulin release.
Progress in lipid research 1986;25(1-4):625-8.
1985: Cecil R Pace-Asciak; J M Martin; E J Corey; W G Su
Endogenous release of hepoxilin A3 from isolated perifused pancreatic islets of Langerhans.
Biochemical and biophysical research communications 1985;128(2):942-6.