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Nick Pace

Research Profile

Chemicals & Drugs

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Protein Denaturation

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Thermodynamics

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Streptomyces aureofaciens

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Amino Acid Sequences

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Publications

TOP 3
Ryan M Kramer; Nicole Motl; C Nick Pace; Varad R Shende; J Martin Scholtz
Toward a molecular understanding of protein solubility: increased negative surface charge correlates with increased solubility.
C Nick Pace; Hailong Fu; Katrina Lee Fryar; John Landua; Saul R Trevino; Bret A Shirley; Marsha McNutt Hendricks; Satoshi Iimura; Ketan Gajiwala; J Martin Scholtz; Gerald R Grimsley
Contribution of hydrophobic interactions to protein stability.
Hailong Fu; Gerald R Grimsley; J Martin Scholtz; C Nick Pace
Increasing protein stability: importance of DeltaC(p) and the denatured state.

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All Publications

2012: Ryan M Kramer; Nicole Motl; C Nick Pace; Varad R Shende; J Martin Scholtz
Toward a molecular understanding of protein solubility: increased negative surface charge correlates with increased solubility.
Biophysical journal 2012;102(8):1907-15.
2011: C Nick Pace; Hailong Fu; Katrina Lee Fryar; John Landua; Saul R Trevino; Bret A Shirley; Marsha McNutt Hendricks; Satoshi Iimura; Ketan Gajiwala; J Martin Scholtz; Gerald R Grimsley
Contribution of hydrophobic interactions to protein stability.
Journal of molecular biology 2011;408(3):514-28.
2010: Hailong Fu; Gerald R Grimsley; J Martin Scholtz; C Nick Pace
Increasing protein stability: importance of DeltaC(p) and the denatured state.
Protein science : a publication of the Protein Society 2010;19(5):1044-52.
2010: Janel R McLean; John A McLean; Zhaoxiang Wu; Christopher Becker; Lisa M Pérez; C Nick Pace; J Martin Scholtz; David H Russell
Factors that influence helical preferences for singly charged gas-phase peptide ions: the effects of multiple potential charge-carrying sites.
The journal of physical chemistry. B 2010;114(2):809-16.
2010: C Nick Pace
In memoriam: Reflections on Charles Tanford (1921-2009).
Protein science : a publication of the Protein Society 2010;19(1):1-5.
2009: Hailong Fu; Gerald R Grimsley; Abbas Razvi; J Martin Scholtz; C Nick Pace
Increasing protein stability by improving beta-turns.
Proteins 2009;77(3):491-8.
2009: C Nick Pace
Energetics of protein hydrogen bonds.
Nature structural & molecular biology 2009;16(7):681-2.
2009: C Nick Pace; Gerald R Grimsley; J Martin Scholtz
Protein ionizable groups: pK values and their contribution to protein stability and solubility.
The Journal of biological chemistry 2009;284(20):13285-9.
2009: J Martin Scholtz; Gerald R Grimsley; C Nick Pace
Solvent denaturation of proteins and interpretations of the m value.
Methods in enzymology 2009;466():549-65.
2009: Gerald R Grimsley; J Martin Scholtz; C Nick Pace
A summary of the measured pK values of the ionizable groups in folded proteins.
Protein science : a publication of the Protein Society 2009;18(1):247-51.
2009: Kevin L Shaw; J Martin Scholtz; C Nick Pace; Gerald R Grimsley
Determining the conformational stability of a protein using urea denaturation curves.
Methods in molecular biology (Clifton, N.J.) 2009;490():41-55.
2008: Saul R Trevino; J Martin Scholtz; C Nick Pace
Measuring and increasing protein solubility.
Journal of pharmaceutical sciences 2008;97(10):4155-66.
2008: Olga N Ilinskaya; Andreas Koschinski; Holger Repp; Vladmir Mitkevich; Florian Dreyer; J Martin Scholtz; C Nick Pace; Alexander A Makarov
RNase-induced apoptosis: fate of calcium-activated potassium channels.
Biochimie 2008;90(5):717-25.
2008: Roy W Alston; Mauricio Lasagna; Gerald R Grimsley; J Martin Scholtz; Gregory D Reinhart; C Nick Pace
Peptide sequence and conformation strongly influence tryptophan fluorescence.
Biophysical journal 2008;94(6):2280-7.
2008: Roy W Alston; Mauricio Lasagna; Gerald R Grimsley; J Martin Scholtz; Gregory D Reinhart; C Nick Pace
Tryptophan fluorescence reveals the presence of long-range interactions in the denatured state of ribonuclease Sa.
Biophysical journal 2008;94(6):2288-96.
2007: Saul R Trevino; Stephanie Schaefer; J Martin Scholtz; C Nick Pace
Increasing protein conformational stability by optimizing beta-turn sequence.
Journal of molecular biology 2007;373(1):211-8.
2007: Saul R Trevino; J Martin Scholtz; C Nick Pace
Amino acid contribution to protein solubility: Asp, Glu, and Ser contribute more favorably than the other hydrophilic amino acids in RNase Sa.
Journal of molecular biology 2007;366(2):449-60.
2006: Richard L Thurlkill; Gerald R Grimsley; J Martin Scholtz; C Nick Pace
Hydrogen bonding markedly reduces the pK of buried carboxyl groups in proteins.
Journal of molecular biology 2006;362(3):594-604.
2006: Richard L Thurlkill; Gerald R Grimsley; J Martin Scholtz; C Nick Pace
pK values of the ionizable groups of proteins.
Protein science : a publication of the Protein Society 2006;15(5):1214-8.
2006: David Schell; Jerry Tsai; J Martin Scholtz; C Nick Pace
Hydrogen bonding increases packing density in the protein interior.
Proteins 2006;63(2):278-82.
2006: Gerald R Grimsley; Beatrice M P Huyghues-Despointes; C Nick Pace; J Martin Scholtz
Measuring the conformational stability of a protein by NMR.
CSH protocols 2006;2006(1):.
2006: Gerald R Grimsley; Beatrice M P Huyghues-Despointes; C Nick Pace; J Martin Scholtz
Determining a thermal unfolding curve.
CSH protocols 2006;2006(1):.
2006: Gerald R Grimsley; Beatrice M P Huyghues-Despointes; C Nick Pace; J Martin Scholtz
Determining a urea or guanidinium chloride unfolding curve.
CSH protocols 2006;2006(1):.
2006: Gerald R Grimsley; Beatrice M P Huyghues-Despointes; C Nick Pace; J Martin Scholtz
Preparation of urea and guanidinium chloride stock solutions for measuring denaturant-induced unfolding curves.
CSH protocols 2006;2006(1):.
2005: Saul R Trevino; Kuppan Gokulan; Stephanie Newsom; Richard L Thurlkill; Kevin L Shaw; Vladmir Mitkevich; Alexander A Makarov; James C Sacchettini; J Martin Scholtz; C Nick Pace
Asp79 makes a large, unfavorable contribution to the stability of RNase Sa.
Journal of molecular biology 2005;354(4):967-78.
2005: Richard L Thurlkill; David A Cross; J Martin Scholtz; C Nick Pace
pKa of fentanyl varies with temperature: implications for acid-base management during extremes of body temperature.
Journal of cardiothoracic and vascular anesthesia 2005;19(6):759-62.
2005: Jared M Trefethen; C Nick Pace; J Martin Scholtz; David N Brems
Charge-charge interactions in the denatured state influence the folding kinetics of ribonuclease Sa.
Protein science : a publication of the Protein Society 2005;14(7):1934-8.
2005: Douglas V Laurents; J Martin Scholtz; Manuel Rico; C Nick Pace; Marta Bruix
Ribonuclease Sa conformational stability studied by NMR-monitored hydrogen exchange.
Biochemistry 2005;44(21):7644-55.
2004: Roy W Alston; Lubica Urbanikova; Jozef Sevcik; Mauricio Lasagna; Gregory D Reinhart; J Martin Scholtz; C Nick Pace
Contribution of single tryptophan residues to the fluorescence and stability of ribonuclease Sa.
Biophysical journal 2004;87(6):4036-47.
2004: Gerald R Grimsley; C Nick Pace
Spectrophotometric determination of protein concentration.
Current protocols in protein science / editorial board, John E. Coligan ... [et al.] 2004;Chapter 3():Unit 3.1.
2004: C Nick Pace; Saul Treviño; Erode Prabhakaran; J Martin Scholtz
Protein structure, stability and solubility in water and other solvents.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2004;359(1448):1225-34; discussion 1234-5.
2004: Olga N Ilinskaya; Andreas Koschinski; Vladmir Mitkevich; Holger Repp; Florian Dreyer; C Nick Pace; Alexander A Makarov
Cytotoxicity of RNases is increased by cationization and counteracted by K(Ca) channels.
Biochemical and biophysical research communications 2004;314(2):550-4.
2003: Gennady I Yakovlev; Vladmir Mitkevich; Kevin L Shaw; Saul Trevino; Stephanie Newsom; C Nick Pace; Alexander A Makarov
Contribution of active site residues to the activity and thermal stability of ribonuclease Sa.
Protein science : a publication of the Protein Society 2003;12(10):2367-73.
2003: Kazufumi Takano; J Martin Scholtz; James C Sacchettini; C Nick Pace
The contribution of polar group burial to protein stability is strongly context-dependent.
The Journal of biological chemistry 2003;278(34):31790-5.
2003: Beatrice M P Huyghues-Despointes; Richard L Thurlkill; Michael D Daily; David Schell; James M Briggs; Jan M Antosiewicz; C Nick Pace; J Martin Scholtz
pK values of histidine residues in ribonuclease Sa: effect of salt and net charge.
Journal of molecular biology 2003;325(5):1093-105.
2003: Douglas V Laurents; Beatrice M P Huyghues-Despointes; Marta Bruix; Richard L Thurlkill; David Schell; Stephanie Newsom; Gerald R Grimsley; Kevin L Shaw; Saul Treviño; Manuel Rico; James M Briggs; Jan M Antosiewicz; J Martin Scholtz; C Nick Pace
Charge-charge interactions are key determinants of the pK values of ionizable groups in ribonuclease Sa (pI=3.5) and a basic variant (pI=10.2).
Journal of molecular biology 2003;325(5):1077-92.
2002: C Nick Pace; Beatrice M P Huyghues-Despointes; James M Briggs; Gerald R Grimsley; J Martin Scholtz
Charge-charge interactions are the primary determinants of the pK values of the ionizable groups in Ribonuclease T1.
Biophysical chemistry 2002;101-102():211-9.
2002: Olga N Ilinskaya; Florian Dreyer; Vladmir Mitkevich; Kevin L Shaw; C Nick Pace; Alexander A Makarov
Changing the net charge from negative to positive makes ribonuclease Sa cytotoxic.
Protein science : a publication of the Protein Society 2002;11(10):2522-5.
2002: Alexey A Schulga; Alexander A Makarov; Iliya V Levichkin; Yuliya V Belousova; Vladimir M Lobachov; Irina I Protasevich; C Nick Pace; Mikhail P Kirpichnikov
Increased stability of human growth hormone with reduced lactogenic potency.
FEBS letters 2002;528(1-3):257-60.
2001: C Nick Pace; G Horn; EJ Hebert; Charles Bechert; K Shaw; Lubica Urbanikova; J Martin Scholtz; Jozef Sevcik
Tyrosine hydrogen bonds make a large contribution to protein stability.
Journal of molecular biology 2001;312(2):393-404.
2001: Douglas V Laurents; José Manuel Pérez-Cañadillas; Jorge Santoro; Manuel Rico; David Schell; C Nick Pace; Marta Bruix
Solution structure and dynamics of ribonuclease Sa.
Proteins 2001;44(3):200-11.
2001: Kevin L Shaw; Gerald R Grimsley; Gennady I Yakovlev; Alexander A Makarov; C Nick Pace
The effect of net charge on the solubility, activity, and stability of ribonuclease Sa.
Protein science : a publication of the Protein Society 2001;10(6):1206-15.
2001: C Nick Pace
Polar group burial contributes more to protein stability than nonpolar group burial.
Biochemistry 2001;40(2):310-3.
2001: Beatrice M P Huyghues-Despointes; C Nick Pace; S W Englander; J Martin Scholtz
Measuring the conformational stability of a protein by hydrogen exchange.
Methods in molecular biology (Clifton, N.J.) 2001;168():69-92.
2000: C Nick Pace; Roy W Alston; Kevin L Shaw
Charge-charge interactions influence the denatured state ensemble and contribute to protein stability.
Protein science : a publication of the Protein Society 2000;9(7):1395-8.
2000: C Nick Pace; Kevin L Shaw
Linear extrapolation method of analyzing solvent denaturation curves.
Proteins 2000;Suppl 4():1-7.
1999: Beatrice M P Huyghues-Despointes; U Langhorst; Jan Steyaert; C Nick Pace; J Martin Scholtz
Hydrogen-exchange stabilities of RNase T1 and variants with buried and solvent-exposed Ala --> Gly mutations in the helix.
Biochemistry 1999;38(50):16481-90.
1999: Beatrice M P Huyghues-Despointes; J Martin Scholtz; C Nick Pace
Protein conformational stabilities can be determined from hydrogen exchange rates.
Nature structural biology 1999;6(10):910-2.
1999: Gerald R Grimsley; Kevin L Shaw; L R Fee; Roy W Alston; Beatrice M P Huyghues-Despointes; Richard L Thurlkill; J Martin Scholtz; C Nick Pace
Increasing protein stability by altering long-range coulombic interactions.
Protein science : a publication of the Protein Society 1999;8(9):1843-9.
1999: C Nick Pace; Gerald R Grimsley; Susan T Thomas; George I Makhatadze
Heat capacity change for ribonuclease A folding.
Protein science : a publication of the Protein Society 1999;8(7):1500-4.
1998: EJ Hebert; A Giletto; Jozef Sevcik; Lubica Urbanikova; Keith S Wilson; Zbigniew Dauter; C Nick Pace
Contribution of a conserved asparagine to the conformational stability of ribonucleases Sa, Ba, and T1.
Biochemistry 1998;37(46):16192-200.
1998: C Nick Pace; J Martin Scholtz
A helix propensity scale based on experimental studies of peptides and proteins.
Biophysical journal 1998;75(1):422-7.
1998: C Nick Pace; EJ Hebert; Kevin L Shaw; David Schell; V Both; Daniela Krajcikova; Jozef Sevcik; Keith S Wilson; Zbigniew Dauter; RW Hartley; Gerald R Grimsley
Conformational stability and thermodynamics of folding of ribonucleases Sa, Sa2 and Sa3.
Journal of molecular biology 1998;279(1):271-86.
1998: JK Myers; C Nick Pace; J Martin Scholtz
Trifluoroethanol effects on helix propensity and electrostatic interactions in the helical peptide from ribonuclease T1.
Protein science : a publication of the Protein Society 1998;7(2):383-8.
1997: Janet K Grimsley; J Martin Scholtz; C Nick Pace; James R Wild
Organophosphorus hydrolase is a remarkably stable enzyme that unfolds through a homodimeric intermediate.
Biochemistry 1997;36(47):14366-74.
1997: EJ Hebert; Gerald R Grimsley; RW Hartley; G Horn; David Schell; S Garcia; V Both; Jozef Sevcik; C Nick Pace
Purification of ribonucleases Sa, Sa2, and Sa3 after expression in Escherichia coli.
Protein expression and purification 1997;11(2):162-8.
1997: JK Myers; C Nick Pace; J Martin Scholtz
Helix propensities are identical in proteins and peptides.
Biochemistry 1997;36(36):10923-9.
1997: JK Myers; C Nick Pace; J Martin Scholtz
A direct comparison of helix propensity in proteins and peptides.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):2833-7.
1996: J K Myers; J S Smith; C Nick Pace; J Martin Scholtz
The alpha-helix of ribonuclease T1 as an independent stability unit: direct comparison of peptide and protein stability.
Journal of molecular biology 1996;263(3):390-5.
1996: J K Myers; C Nick Pace
Hydrogen bonding stabilizes globular proteins.
Biophysical journal 1996;71(4):2033-9.
1996: C Nick Pace; B A Shirley; M McNutt; K Gajiwala
Forces contributing to the conformational stability of proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(1):75-83.
1995: C Nick Pace; F Vajdos; L Fee; Gerald R Grimsley; T Gray
How to measure and predict the molar absorption coefficient of a protein.
Protein science : a publication of the Protein Society 1995;4(11):2411-23.
1995: J K Myers; C Nick Pace; J Martin Scholtz
Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding.
Protein science : a publication of the Protein Society 1995;4(10):2138-48.
1995: C Nick Pace
Evaluating contribution of hydrogen bonding and hydrophobic bonding to protein folding.
Methods in enzymology 1995;259():538-54.
1994: Yihua Bruce Yu; George I Makhatadze; C Nick Pace; Peter L Privalov
Energetics of ribonuclease T1 structure.
Biochemistry 1994;33(11):3312-9.
1993: LS Mullins; C Nick Pace; Frank M Raushel
Investigation of ribonuclease T1 folding intermediates by hydrogen-deuterium amide exchange-two-dimensional NMR spectroscopy.
Biochemistry 1993;32(24):6152-6.
1992: I M Plaza del Pino; C Nick Pace; Ernesto Freire
Temperature and guanidine hydrochloride dependence of the structural stability of ribonuclease T1.
Biochemistry 1992;31(45):11196-202.
1992: C Nick Pace
Contribution of the hydrophobic effect to globular protein stability.
Journal of molecular biology 1992;226(1):29-35.
1992: C Nick Pace; Douglas V Laurents; R E Erickson
Urea denaturation of barnase: pH dependence and characterization of the unfolded state.
Biochemistry 1992;31(10):2728-34.
1992: B A Shirley; P Stanssens; Ulrich Hahn; C Nick Pace
Contribution of hydrogen bonding to the conformational stability of ribonuclease T1.
Biochemistry 1992;31(3):725-32.
1990: M McNutt; LS Mullins; Frank M Raushel; C Nick Pace
Contribution of histidine residues to the conformational stability of ribonuclease T1 and mutant Glu-58----Ala.
Biochemistry 1990;29(33):7572-6.
1990: C Nick Pace
Measuring and increasing protein stability.
Trends in biotechnology 1990;8(4):93-8.
1990: C Nick Pace; Douglas V Laurents; J A Thomson
pH dependence of the urea and guanidine hydrochloride denaturation of ribonuclease A and ribonuclease T1.
Biochemistry 1990;29(10):2564-72.
1990: C Nick Pace
Conformational stability of globular proteins.
Trends in biochemical sciences 1990;15(1):14-7.
1989: J A Thomson; B A Shirley; Gerald R Grimsley; C Nick Pace
Conformational stability and mechanism of folding of ribonuclease T1.
The Journal of biological chemistry 1989;264(20):11614-20.
1989: B A Shirley; P Stanssens; Jan Steyaert; C Nick Pace
Conformational stability and activity of ribonuclease T1 and mutants. Gln25----Lys, Glu58----Ala, and the double mutant.
The Journal of biological chemistry 1989;264(20):11621-5.
1989: C Nick Pace; Douglas V Laurents
A new method for determining the heat capacity change for protein folding.
Biochemistry 1989;28(6):2520-5.
1988: C Nick Pace; Gerald R Grimsley; J A Thomson; B J Barnett
Conformational stability and activity of ribonuclease T1 with zero, one, and two intact disulfide bonds.
The Journal of biological chemistry 1988;263(24):11820-5.
1988: C Nick Pace; Gerald R Grimsley
Ribonuclease T1 is stabilized by cation and anion binding.
Biochemistry 1988;27(9):3242-6.
1987: C Nick Pace; Gerald R Grimsley; B J Barnett
Purification of ribonuclease T1.
Analytical biochemistry 1987;167(2):418-22.
1980: P J Langston; C Nick Pace; G E Hart
Wheat Alcohol Dehydrogenase Isozymes: PURIFICATION, CHARACTERIZATION, AND GENE EXPRESSION.
Plant physiology 1980;65(3):518-22.