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Jan Paeshuyse

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Maria Letizia Barreca; Amartya Basu; U Helena Danielson; Nunzio Iraci; Neerja Kaushik-Basu; Ramalingam Krishnan; Pieter Leyssen; Giuseppe Manfroni; Johan Neyts; Jan Paeshuyse; Stefano Sabatini; Oriana Tabarrini; Johan Winquist; Violetta Cecchetti
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.
Rob Lavigne; Elke Lecoutere; Jan Paeshuyse; Maurice Scheer; Max Schobert; Liliane Schoofs; Jeroen Wagemans; Abram Aertsen; William Cenens; Bart Landuyt; Pieter-Jan Ceyssens
A multifaceted study of Pseudomonas aeruginosa shutdown by virulent podovirus LUZ19.
Leen Delang; Jan Paeshuyse; Johan Neyts
The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication.

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All Publications

2013: Maria Letizia Barreca; Amartya Basu; U Helena Danielson; Nunzio Iraci; Neerja Kaushik-Basu; Ramalingam Krishnan; Pieter Leyssen; Giuseppe Manfroni; Johan Neyts; Jan Paeshuyse; Stefano Sabatini; Oriana Tabarrini; Johan Winquist; Violetta Cecchetti
Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication.
Journal of medicinal chemistry 2013;56(6):2270-82.
2013: Rob Lavigne; Elke Lecoutere; Jan Paeshuyse; Maurice Scheer; Max Schobert; Liliane Schoofs; Jeroen Wagemans; Abram Aertsen; William Cenens; Bart Landuyt; Pieter-Jan Ceyssens
A multifaceted study of Pseudomonas aeruginosa shutdown by virulent podovirus LUZ19.
mBio 2013;4(2):e00061-13.
2012: Leen Delang; Jan Paeshuyse; Johan Neyts
The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication.
Biochemical pharmacology 2012;84(11):1400-8.
2012: Philip Roelandt; Alfons Van Lommel; Jolien Vanhove; Yaakov Nahmias; Frederik Nevens; Johan Neyts; Susan Obeid; Jan Paeshuyse; Catherine M Verfaillie
Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus.
Journal of hepatology 2012;57(2):246-51.
2012: Kristof Vrancken; Jan Paeshuyse; Sandra Liekens
Angiogenic activity of hepatitis B and C viruses.
Antiviral chemistry & chemotherapy 2012;22(4):159-70.
2011: Jan Paeshuyse; Kai Dallmeier; Johan Neyts
Ribavirin for the treatment of chronic hepatitis C virus infection: a review of the proposed mechanisms of action.
Current opinion in virology 2011;1(6):590-8.
2011: I-Hung Shih; Yang Tian; Winston Tse; Inge Vliegen; Huiling Yang; Gina Bahador; Steven Bondy; Martijn Fenaux; Christy Hebner; William A Lee; Laura S Lehman; Eric Mabery; Johan Neyts; Jan Paeshuyse; Matthew Paulson; Betty Peng; Gerhard Pürstinger; Xiaoping Qi; Hans Reiser; Uli Schmitz; Weidong Zhong
Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase.
Antimicrobial agents and chemotherapy 2011;55(9):4196-203.
2011: Susan Obeid; Svetlana S Printsevskaya; Evgenia N Olsufyeva; Kai Dallmeier; David Durantel; Fabien Zoulim; Maria N Preobrazhenskaya; Johan Neyts; Jan Paeshuyse
Inhibition of hepatitis C virus replication by semi-synthetic derivatives of glycopeptide antibiotics.
The Journal of antimicrobial chemotherapy 2011;66(6):1287-94.
2011: Matthew A Gregory; Michael Bobardt; Susan Obeid; Udayan Chatterji; Nigel J Coates; Teresa Foster; Philippe Gallay; Pieter Leyssen; Steven J Moss; Johan Neyts; Mohammad Nur-e-Alam; Jan Paeshuyse; Mahmood Piraee; Dipen Suthar; Tony Warneck; Ming-Qiang Zhang; Barrie Wilkinson
Preclinical characterization of naturally occurring polyketide cyclophilin inhibitors from the sanglifehrin family.
Antimicrobial agents and chemotherapy 2011;55(5):1975-81.
2010: Mohammed T A Salim; Yukinori Goto; Takayuki Hamasaki; Mika Okamoto; Hiroshi Aoyama; Yuichi Hashimoto; Simone Musiu; Jan Paeshuyse; Johan Neyts; Matheus Froeyen; Piet Herdewijn; Masanori Baba
Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives.
Antiviral research 2010;88(3):263-8.
2010: Jean-Michel Chezal; Jan Paeshuyse; Vincent Gaumet; Damien Canitrot; Aurélie Maisonial; Claire Lartigue; Alain Gueiffier; Emmanuel Moreau; Jean-Claude Teulade; Olivier Chavignon; Johan Neyts
Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus.
European journal of medicinal chemistry 2010;45(5):2044-7.
2010: Lotte Coelmont; Xavier Hanoulle; Udayan Chatterji; Carola Berger; Joke Snoeck; Michael Bobardt; Precious Lim; Inge Vliegen; Jan Paeshuyse; Grégoire Vuagniaux; Anne-Mieke Vandamme; Ralf Bartenschlager; Philippe Gallay; Guy Lippens; Johan Neyts
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A.
PloS one 2010;5(10):e13687.
2009: R Vrancken; A Haegeman; Jeroen Dewulf; Jan Paeshuyse; Gerhard Puerstinger; M Tignon; Marie-Frédérique Le Potier; Johan Neyts; Frank Koenen
The reduction of CSFV transmission to untreated pigs by the pestivirus inhibitor BPIP: a proof of concept.
Veterinary microbiology 2009;139(3-4):365-8.
2009: Leen Delang; Jan Paeshuyse; Inge Vliegen; Pieter Leyssen; Susan Obeid; David Durantel; Fabien Zoulim; Anne Op de Beeck; Johan Neyts
Statins potentiate the in vitro anti-hepatitis C virus activity of selective hepatitis C virus inhibitors and delay or prevent resistance development.
Hepatology (Baltimore, Md.) 2009;50(1):6-16.
2009: Jan Paeshuyse; Carine Letellier; Matheus Froeyen; Hélène Dutartre; Robert Vrancken; Bruno Canard; Erik De Clercq; Alain Gueiffier; Jean-Claude Teulade; Piet Herdewijn; Gerhard Puerstinger; Frank Koenen; Pierre Kerkhofs; Pier Giovanni Baraldi; Johan Neyts
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.
Antiviral research 2009;82(3):141-7.
2009: Robert Vrancken; Andy Haegeman; Jan Paeshuyse; Gerhard Puerstinger; Jef Rozenski; Matthew Wright; Marylène Tignon; Marie-Frédérique Le Potier; Johan Neyts; Frank Koenen
Proof of concept for the reduction of classical swine fever infection in pigs by a novel viral polymerase inhibitor.
The Journal of general virology 2009;90(Pt 6):1335-42.
2009: Giuseppe Manfroni; Jan Paeshuyse; Serena Massari; Samantha Zanoli; Barbara Gatto; Giovanni Maga; Oriana Tabarrini; Violetta Cecchetti; Arnaldo Fravolini; Johan Neyts
Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor.
Journal of medicinal chemistry 2009;52(10):3354-65.
2009: Inge Vliegen; Jan Paeshuyse; Tine De Burghgraeve; Laura S Lehman; Matthew Paulson; I-Hung Shih; Eric Mabery; Nina Boddeker; Erik De Clercq; Hans Reiser; David Oare; William A Lee; Weidong Zhong; Steven Bondy; Gerhard Pürstinger; Johan Neyts
Substituted imidazopyridines as potent inhibitors of HCV replication.
Journal of hepatology 2009;50(5):999-1009.
2009: Lotte Coelmont; Suzanne Kaptein; Jan Paeshuyse; Inge Vliegen; Jean-Maurice Dumont; Grégoire Vuagniaux; Johan Neyts
Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors.
Antimicrobial agents and chemotherapy 2009;53(3):967-76.
2008: Jan Paeshuyse; Inge Vliegen; Lotte Coelmont; Pieter Leyssen; Oriana Tabarrini; Piet Herdewijn; Harald Mittendorfer; Johnny Easmon; Violetta Cecchetti; Ralf Bartenschlager; Gerhard Puerstinger; Johan Neyts
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors.
Antimicrobial agents and chemotherapy 2008;52(9):3433-7.
2008: Robert Vrancken; Jan Paeshuyse; A Haegeman; Gerhard Puerstinger; Matheus Froeyen; Piet Herdewijn; Pierre Kerkhofs; Johan Neyts; Frank Koenen
Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.
Antiviral research 2008;77(2):114-9.
2007: Jan Paeshuyse; Jean-Michel Chezal; Matheus Froeyen; Pieter Leyssen; Hélène Dutartre; Robert Vrancken; Bruno Canard; Carine Letellier; Tong Li; Harald Mittendorfer; Frank Koenen; Pierre Kerkhofs; Erik De Clercq; Piet Herdewijn; Gerhard Puerstinger; Alain Gueiffier; Olivier Chavignon; Jean-Claude Teulade; Johan Neyts
The imidazopyrrolopyridine analogue AG110 is a novel, highly selective inhibitor of pestiviruses that targets the viral RNA-dependent RNA polymerase at a hot spot for inhibition of viral replication.
Journal of virology 2007;81(20):11046-53.
2007: Gerhard Puerstinger; Jan Paeshuyse; Susanne Heinrich; Joachim Mohr; Nicole Schraffl; Erik De Clercq; Johan Neyts
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: further optimization of anti-hepatitis C virus activity.
Bioorganic & medicinal chemistry letters 2007;17(18):5111-4.
2007: Gerhard Puerstinger; Jan Paeshuyse; Erik De Clercq; Johan Neyts
Antiviral 2,5-disubstituted imidazo[4,5-c]pyridines: from anti-pestivirus to anti-hepatitis C virus activity.
Bioorganic & medicinal chemistry letters 2007;17(2):390-3.
2006: Gerhard Puerstinger; Jan Paeshuyse; Piet Herdewijn; Jef Rozenski; Erik De Clercq; Johan Neyts
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(20):5345-9.
2006: Lotte Coelmont; Jan Paeshuyse; Marc P Windisch; Erik De Clercq; Ralf Bartenschlager; Johan Neyts
Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2'-C-methylcytidine, the active component of valopicitabine.
Antimicrobial agents and chemotherapy 2006;50(10):3444-6.
2006: Jan Paeshuyse; Lotte Coelmont; Inge Vliegen; Johan Van hemel; Jan Vandenkerckhove; Eric Peys; Benedikt Sas; Erik De Clercq; Johan Neyts
Hemin potentiates the anti-hepatitis C virus activity of the antimalarial drug artemisinin.
Biochemical and biophysical research communications 2006;348(1):139-44.
2006: Oriana Tabarrini; Giuseppe Manfroni; Arnaldo Fravolini; Violetta Cecchetti; Stefano Sabatini; Erik De Clercq; Jef Rozenski; Bruno Canard; Hélène Dutartre; Jan Paeshuyse; Johan Neyts
Synthesis and anti-BVDV activity of acridones as new potential antiviral agents.
Journal of medicinal chemistry 2006;49(8):2621-7.
2006: Jan Paeshuyse; Artur Kaul; Erik De Clercq; Brigitte Rosenwirth; Jean-Maurice Dumont; Pietro Scalfaro; Ralf Bartenschlager; Johan Neyts
The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro.
Hepatology (Baltimore, Md.) 2006;43(4):761-70.
2006: Jan Paeshuyse; Pieter Leyssen; Eric Mabery; Nina Boddeker; Robert Vrancken; Matheus Froeyen; Israrul H Ansari; Hélène Dutartre; Jef Rozenski; Laura H V G Gil; Carine Letellier; Robert E Lanford; Bruno Canard; Frank Koenen; Pierre Kerkhofs; Ruben O Donis; Piet Herdewijn; Julia Watson; Erik De Clercq; Gerhard Puerstinger; Johan Neyts
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase.
Journal of virology 2006;80(1):149-60.
2004: Nathalie Charlier; Richard Molenkamp; Pieter Leyssen; Jan Paeshuyse; Christian Drosten; Marcus Panning; Erik De Clercq; Peter J Bredenbeek; Johan Neyts
Exchanging the yellow fever virus envelope proteins with Modoc virus prM and E proteins results in a chimeric virus that is neuroinvasive in SCID mice.
Journal of virology 2004;78(14):7418-26.
2003: Pieter Leyssen; Romaric Croes; Philipp R Rau; Sabine Heiland; Erik Verbeken; Raphael Sciot; Jan Paeshuyse; Nathalie Charlier; Erik De Clercq; Uta Meyding-Lamadé; Johan Neyts
Acute encephalitis, a poliomyelitis-like syndrome and neurological sequelae in a hamster model for flavivirus infections.
Brain pathology (Zurich, Switzerland) 2003;13(3):279-90.
2003: Pieter Leyssen; Jan Paeshuyse; Nathalie Charlier; Alfons Van Lommel; Christian Drosten; Erik De Clercq; Johan Neyts
Impact of direct virus-induced neuronal dysfunction and immunological damage on the progression of flavivirus (Modoc) encephalitis in a murine model.
Journal of neurovirology 2003;9(1):69-78.
2003: Pieter Leyssen; Christian Drosten; Marcus Paning; Nathalie Charlier; Jan Paeshuyse; Erik De Clercq; Johan Neyts
Interferons, interferon inducers, and interferon-ribavirin in treatment of flavivirus-induced encephalitis in mice.
Antimicrobial agents and chemotherapy 2003;47(2):777-82.
2003: Pieter Leyssen; Nathalie Charlier; Jan Paeshuyse; Erik De Clercq; Johan Neyts
Prospects for antiviral therapy.
Advances in virus research 2003;61():511-53.
2002: Nathalie Charlier; Pieter Leyssen; Jan Paeshuyse; Christian Drosten; Herbert Schmitz; Alfons Van Lommel; Erik De Clercq; Johan Neyts
Infection of SCID mice with Montana Myotis leukoencephalitis virus as a model for flavivirus encephalitis.
The Journal of general virology 2002;83(Pt 8):1887-96.