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Paolo Paganetti

Research Profile

Chemicals & Drugs

Anatomy

Living Beings

Physiology

Disorders

Alzheimer's Disease

Concepts & Ideas

Phenomena

Glycosylation

Genes & Molecular Sequences

Amino Acid Sequences

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Publications

TOP 3
Barbara Baldo; Gillian P Bates; Stephan Grueninger; Linda S Kaltenbach; Donald C Lo; Gregor P Lotz; David Marcellin; Paolo Paganetti; Martin Semmelroth; Donna Smith; Dorothee Abramowski; Andjelija Zivanovic; Andreas Weiss
TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.
Omar Vanoni; Paolo Paganetti; Maurizio Molinari
Consequences of individual N-glycan deletions and of proteasomal inhibition on secretion of active BACE.
Martin C Herzig; Paolo Paganetti; Matthias Staufenbiel; Mathias Jucker
BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.

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All Publications

2012: Barbara Baldo; Gillian P Bates; Stephan Grueninger; Linda S Kaltenbach; Donald C Lo; Gregor P Lotz; David Marcellin; Paolo Paganetti; Martin Semmelroth; Donna Smith; Dorothee Abramowski; Andjelija Zivanovic; Andreas Weiss
TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease.
Chemistry & biology 2012;19(2):264-75.
2008: Omar Vanoni; Paolo Paganetti; Maurizio Molinari
Consequences of individual N-glycan deletions and of proteasomal inhibition on secretion of active BACE.
Molecular biology of the cell 2008;19(10):4086-98.
2007: Martin C Herzig; Paolo Paganetti; Matthias Staufenbiel; Mathias Jucker
BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice.
Neuro-degenerative diseases 2007;4(2-3):127-35.
2006: Silvia Olivari; Tito Cali; Kirsi E H Salo; Paolo Paganetti; Lloyd W Ruddock; Maurizio Molinari
EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation.
Biochemical and biophysical research communications 2006;349(4):1278-84.
2006: Melanie Meyer-Luehmann; Janaky Coomaraswamy; Tristan Bolmont; Stephan A Kaeser; Claudia Schaefer; Ellen Kilger; Anton Neuenschwander; Dorothee Abramowski; Peter Frey; Anneliese L Jaton; Jean-Marie Vigouret; Paolo Paganetti; Dominic M Walsh; Paul Mathews; Jorge Ghiso; Matthias Staufenbiel; Lary Walker; Mathias Jucker
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host.
Science (New York, N.Y.) 2006;313(5794):1781-4.
2005: Paolo Paganetti; Verena Calanca; Carmela Galli; Muriel Stefani; Maurizio Molinari
beta-site specific intrabodies to decrease and prevent generation of Alzheimer's Abeta peptide.
The Journal of cell biology 2005;168(6):863-8.
2004: Klara K Eriksson; Riccardo Vago; Verena Calanca; Carmela Galli; Paolo Paganetti; Maurizio Molinari
EDEM contributes to maintenance of protein folding efficiency and secretory capacity.
The Journal of biological chemistry 2004;279(43):44600-5.
2004: Lucia Pastorino; Annat F Ikin; Smaragda Lamprianou; N Vacaresse; J P Revelli; K Platt; Paolo Paganetti; Paul Mathews; Sheila Harroch; Joseph Buxbaum
BACE (beta-secretase) modulates the processing of APLP2 in vivo.
Molecular and cellular neurosciences 2004;25(4):642-9.
2003: Maurizio Molinari; Verena Calanca; Carmela Galli; Paola Lucca; Paolo Paganetti
Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle.
Science (New York, N.Y.) 2003;299(5611):1397-400.
2002: Frauke Fischer; Maurizio Molinari; Ursula Bodendorf; Paolo Paganetti
The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity.
Journal of neurochemistry 2002;80(6):1079-88.
2002: Ursula Bodendorf; Simone Danner; Frauke Fischer; Muriel Stefani; Christine Sturchler-Pierrat; Karl-Heinz Wiederhold; Matthias Staufenbiel; Paolo Paganetti
Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.
Journal of neurochemistry 2002;80(5):799-806.
2001: Ursula Bodendorf; Frauke Fischer; D Bodian; Gerd Multhaup; Paolo Paganetti
A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein.
The Journal of biological chemistry 2001;276(15):12019-23.
2000: Alfredo Lorenzo; M Yuan; Zhuohua Zhang; Paolo Paganetti; Christine Sturchler-Pierrat; Matthias Staufenbiel; J Mautino; F S Vigo; Bernd Sommer; Bruce A Yankner
Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.
Nature neuroscience 2000;3(5):460-4.
2000: R Cescato; E Dumermuth; Martin Spiess; Paolo Paganetti
Increased generation of alternatively cleaved beta-amyloid peptides in cells expressing mutants of the amyloid precursor protein defective in endocytosis.
Journal of neurochemistry 2000;74(3):1131-9.
1998: M E Manni; R Cescato; Paolo Paganetti
Lack of beta-amyloid production in M19 cells deficient in site 2 processing of the sterol regulatory element binding proteins.
FEBS letters 1998;427(3):367-70.
1997: Christine Sturchler-Pierrat; Dorothee Abramowski; M Duke; Karl-Heinz Wiederhold; C Mistl; S Rothacher; Birgit Ledermann; Kurt Bürki; Peter Frey; Paolo Paganetti; C Waridel; Michael E Calhoun; Mathias Jucker; Alphonse Probst; Matthias Staufenbiel; Bernd Sommer
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13287-92.
1997: G Schrader-Fischer; Matthias Staufenbiel; Paolo Paganetti
Insertion of lysosomal targeting sequences to the amyloid precursor protein reduces secretion of beta A4.
Journal of neurochemistry 1997;68(4):1571-80.
1997: KH Baumann; Paolo Paganetti; Christine Sturchler-Pierrat; C Wong; H Hartmann; R Cescato; Peter Frey; Bruce A Yankner; Bernd Sommer; Matthias Staufenbiel
Distinct processing of endogenous and overexpressed recombinant presenilin 1.
Neurobiology of aging 1997;18(2):181-9.
1996: H Klafki; Dorothee Abramowski; R Swoboda; Paolo Paganetti; Matthias Staufenbiel
The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities.
The Journal of biological chemistry 1996;271(45):28655-9.
1996: Paolo Paganetti; M Lis; H W Klafki; Matthias Staufenbiel
Amyloid precursor protein truncated at any of the gamma-secretase sites is not cleaved to beta-amyloid.
Journal of neuroscience research 1996;46(3):283-93.
1996: G Schrader-Fischer; Paolo Paganetti
Effect of alkalizing agents on the processing of the beta-amyloid precursor protein.
Brain research 1996;716(1-2):91-100.
1995: H W Klafki; Paolo Paganetti; Bernd Sommer; Matthias Staufenbiel
Calpain inhibitor I decreases beta A4 secretion from human embryonal kidney cells expressing beta-amyloid precursor protein carrying the APP670/671 double mutation.
Neuroscience letters 1995;201(1):29-32.
1995: B L Martin; G Schrader-Fischer; Jorge Busciglio; M Duke; Paolo Paganetti; Bruce A Yankner
Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein.
The Journal of biological chemistry 1995;270(45):26727-30.