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Malcolm Page

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TOP 3
Christian van Delden; Malcolm G P Page; Thilo Köhler
Involvement of Fe Uptake Systems and AmpC β-Lactamase in Susceptibility to the Siderophore Monosulfactam BAL30072 in Pseudomonas aeruginosa.
Beatrice Hofer; Clothilde Dantier; Eric Desarbre; Klaus Gebhardt; Anne Schmitt-Hoffmann; Malcolm G P Page
Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli.
Malcolm G P Page
Siderophore conjugates.

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All Publications

2013: Christian van Delden; Malcolm G P Page; Thilo Köhler
Involvement of Fe Uptake Systems and AmpC β-Lactamase in Susceptibility to the Siderophore Monosulfactam BAL30072 in Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy 2013;57(5):2095-102.
2013: Beatrice Hofer; Clothilde Dantier; Eric Desarbre; Klaus Gebhardt; Anne Schmitt-Hoffmann; Malcolm G P Page
Combined effects of the siderophore monosulfactam BAL30072 and carbapenems on multidrug-resistant Gram-negative bacilli.
The Journal of antimicrobial chemotherapy 2013;68(5):1120-9.
2013: Malcolm G P Page
Siderophore conjugates.
Annals of the New York Academy of Sciences 2013;1277():115-26.
2012: Andrew L Lovering; Malcolm G P Page; Susan S Safadi; Franck Danel; Liza de Castro; Michael C Gretes; Natalie C J Strynadka
Structural insights into the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of ceftobiprole.
The Journal of biological chemistry 2012;287(38):32096-102.
2012: Paul Higgins; Malcolm G P Page; Meredith Hackel; Danuta Stefanik; Harald Seifert
In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii.
The Journal of antimicrobial chemotherapy 2012;67(5):1167-9.
2012: Malcolm G P Page
The role of the outer membrane of Gram-negative bacteria in antibiotic resistance: Ajax' shield or Achilles' heel?
Handbook of experimental pharmacology 2012;(211):67-86.
2011: Jian Liu; Chuanyun Luo; Mark Paetzel; Malcolm G P Page; Jodie K Chin; Peter A Smith; Floyd E Romesberg
Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase.
Journal of the American Chemical Society 2011;133(44):17869-77.
2011: Takehiko Mima; Malcolm G P Page; Drew A Rholl; Eric Desarbre; Brian H Kvitko; Herbert P Schweizer
In vitro activity of BAL30072 against Burkholderia pseudomallei.
International journal of antimicrobial agents 2011;38(2):157-9.
2011: Thomas A Russo; Malcolm G P Page; Janet M Beanan; Ruth Olson; Andrea M Hujer; Kristine M Hujer; Michael Jacobs; Saralee Bajaksouzian; Andrea Endimiani; Robert A Bonomo
In vivo and in vitro activity of the siderophore monosulfactam BAL30072 against Acinetobacter baumannii.
The Journal of antimicrobial chemotherapy 2011;66(4):867-73.
2011: Malcolm G P Page; Clothilde Dantier; Eric Desarbre; Bérangère Gaucher; Klaus Gebhardt; Anne Schmitt-Hoffmann
In vitro and in vivo properties of BAL30376, a β-lactam and dual beta-lactamase inhibitor combination with enhanced activity against Gram-negative Bacilli that express multiple β-lactamases.
Antimicrobial agents and chemotherapy 2011;55(4):1510-9.
2011: Franck Danel; Patrick Caspers; Claude Nuoffer; Michael Härtlein; Michael A Kron; Malcolm G P Page
Asparaginyl-tRNA synthetase pre-transfer editing assay.
Current drug discovery technologies 2011;8(1):66-75.
2011: Viviana S Fluxà; Noélie Maillard; Malcolm G P Page; Jean-Louis Reymond
Bead diffusion assay for discovering antimicrobial cyclic peptides.
Chemical communications (Cambridge, England) 2011;47(5):1434-6.
2010: Toshikazu Yamazaki; Yukiko Inagaki; Toshihiko Fujii; Jun Ohwada; Masao Tsukazaki; Isao Umeda; Kazuko Kobayashi; Nobuo Shimma; Malcolm G P Page; Mikio Arisawa
In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan.
International journal of antimicrobial agents 2010;36(4):324-31.
2010: Jens Pohlmann; Natalya I Vasilevich; Andrei I Glushkov; Laurenz Kellenberger; Stuart Shapiro; Patrick Caspers; Malcolm G P Page; Franck Danel
Propenylamide and propenylsulfonamide cephalosporins as a novel class of anti-MRSA beta-lactams.
Bioorganic & medicinal chemistry letters 2010;20(15):4635-8.
2010: Malcolm G P Page; Clothilde Dantier; Eric Desarbre
In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.
Antimicrobial agents and chemotherapy 2010;54(6):2291-302.
2010: Andrea Endimiani; Yohei Doi; Christopher R Bethel; Magdalena Taracila; Jennifer M Adams-Haduch; Alexandra O'Keefe; Andrea Hujer; David L Paterson; Marion J Skalweit; Malcolm G P Page; Sarah M Drawz; Robert A Bonomo
Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.
Biochemistry 2010;49(5):1014-23.
2009: Faustino Vidal-Aroca; Alexandra Meng; Tanja Minz; Malcolm G P Page; Jürg Dreier
Use of resazurin to detect mefloquine as an efflux-pump inhibitor in Pseudomonas aeruginosa and Escherichia coli.
Journal of microbiological methods 2009;79(2):232-7.
2009: Malcolm G P Page; Jutta Heim
Prospects for the next anti-Pseudomonas drug.
Current opinion in pharmacology 2009;9(5):558-65.
2009: Chuanyun Luo; Patrick Roussel; Jürg Dreier; Malcolm G P Page; Mark Paetzel
Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a beta-sultam inhibitor.
Biochemistry 2009;48(38):8976-84.
2009: Malcolm G P Page; Jutta Heim
New molecules from old classes: revisiting the development of beta-lactams.
IDrugs : the investigational drugs journal 2009;12(9):561-5.
2007: Jürg Dreier; Eva Amantea; Laurenz Kellenberger; Malcolm G P Page
Activity of the novel macrolide BAL19403 against ribosomes from erythromycin-resistant Propionibacterium acnes.
Antimicrobial agents and chemotherapy 2007;51(12):4361-5.
2007: Malcolm G P Page
Emerging cephalosporins.
Expert opinion on emerging drugs 2007;12(4):511-24.
2007: Anne Marie Queenan; Wenchi Shang; Malgosia Kania; Malcolm G P Page; Karen Bush
Interactions of ceftobiprole with beta-lactamases from molecular classes A to D.
Antimicrobial agents and chemotherapy 2007;51(9):3089-95.
2007: Todd A Davies; Malcolm G P Page; Wenchi Shang; Ted Andrew; Malgosia Kania; Karen Bush
Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy 2007;51(7):2621-4.
2006: Malcolm G P Page
Anti-MRSA beta-lactams in development.
Current opinion in pharmacology 2006;6(5):480-5.
2006: Sai Chetan K Sukuru; Thibaut Crépin; Youli Milev; Liesl C Marsh; Jonathan B Hill; Regan J Anderson; Jonathan C Morris; Anjali Rohatgi; Gavin O'Mahony; Morten Grøtli; Franck Danel; Malcolm G P Page; Michael Härtlein; Stephen Cusack; Michael A Kron; Leslie A Kuhn
Discovering new classes of Brugia malayi asparaginyl-tRNA synthetase inhibitors and relating specificity to conformational change.
Journal of computer-aided molecular design 2006;20(3):159-78.
2006: Estelle Marrer; Karen Schad; Andreas T Satoh; Malcolm G P Page; Maggie M Johnson; Laura J V Piddock
Involvement of the putative ATP-dependent efflux proteins PatA and PatB in fluoroquinolone resistance of a multidrug-resistant mutant of Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy 2006;50(2):685-93.
2006: Estelle Marrer; A Tatsuo Satoh; Margaret M Johnson; Laura J V Piddock; Malcolm G P Page
Global transcriptome analysis of the responses of a fluoroquinolone-resistant Streptococcus pneumoniae mutant and its parent to ciprofloxacin.
Antimicrobial agents and chemotherapy 2006;50(1):269-78.
2005: Andrea Hujer; Malgosia Kania; Thomas Gerken; Vernon E Anderson; John D Buynak; Xiaoxia Ge; Patrick Caspers; Malcolm G P Page; Louis B Rice; Robert A Bonomo
Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase.
Antimicrobial agents and chemotherapy 2005;49(2):612-8.
2004: Louis B Rice; Samuel Bellais; Lenore L Carias; Rebecca Hutton-Thomas; Robert A Bonomo; Patrick Caspers; Malcolm G P Page; Laurent Gutmann
Impact of specific pbp5 mutations on expression of beta-lactam resistance in Enterococcus faecium.
Antimicrobial agents and chemotherapy 2004;48(8):3028-32.
2004: Malcolm G P Page
Cephalosporins in clinical development.
Expert opinion on investigational drugs 2004;13(8):973-85.
2004: Mark Paetzel; Jonathon J Goodall; Malgosia Kania; Ross E Dalbey; Malcolm G P Page
Crystallographic and biophysical analysis of a bacterial signal peptidase in complex with a lipopeptide-based inhibitor.
The Journal of biological chemistry 2004;279(29):30781-90.
2004: Jonathan J Goodall; Guo Jun Chen; Malcolm G P Page
Essential role of histidine 20 in the catalytic mechanism of Escherichia coli peptidyl-tRNA hydrolase.
Biochemistry 2004;43(15):4583-91.
2003: Alan-Shaun Wilkinson; Patrick K Bryant; Samy O Meroueh; Malcolm G P Page; Shahriar Mobashery; Christopher W Wharton
A dynamic structure for the acyl-enzyme species of the antibiotic aztreonam with the Citrobacter freundii beta-lactamase revealed by infrared spectroscopy and molecular dynamics simulations.
Biochemistry 2003;42(7):1950-7.
2002: Christian Wagner; Antoine de Saizieu Ad; Hans-Joachim Schönfeld; Markus Kamber; Roland Lange; Charles J Thompson; Malcolm G P Page
Genetic analysis and functional characterization of the Streptococcus pneumoniae vic operon.
Infection and immunity 2002;70(11):6121-8.
2002: Andrea Hujer; Malcolm G P Page; Marion S Helfand; Bethany Yeiser; Robert A Bonomo
Development of a sensitive and specific enzyme-linked immunosorbent assay for detecting and quantifying CMY-2 and SHV beta-lactamases.
Journal of clinical microbiology 2002;40(6):1947-57.
2002: Jürg Dreier; Eva B Breitmaier; Elmar Gocke; Christian M Apfel; Malcolm G P Page
Direct influence of S9 liver homogenate on fluorescence signals: impact on practical applications in a bacterial genotoxicity assay.
Mutation research 2002;513(1-2):169-82.
2001: Franck Danel; Mark Paetzel; Natalie C J Strynadka; Malcolm G P Page
Effect of divalent metal cations on the dimerization of OXA-10 and -14 class D beta-lactamases from Pseudomonas aeruginosa.
Biochemistry 2001;40(31):9412-20.
2001: Christian M Apfel; Hans H Locher; S Evers; B Takács; Christian Hubschwerlen; W Pirson; Malcolm G P Page; Wolfgang Keck
Peptide deformylase as an antibacterial drug target: target validation and resistance development.
Antimicrobial agents and chemotherapy 2001;45(4):1058-64.
2001: Christian M Apfel; S Evers; Christian Hubschwerlen; W Pirson; Malcolm G P Page; Wolfgang Keck
Peptide deformylase as an antibacterial drug target: assays for detection of its inhibition in Escherichia coli cell homogenates and intact cells.
Antimicrobial agents and chemotherapy 2001;45(4):1053-7.
2001: Paul Hebeisen; I Heinze-Krauss; Peter Angehrn; Peter Hohl; Malcolm G P Page; Rudolf L Then
In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci.
Antimicrobial agents and chemotherapy 2001;45(3):825-36.
2000: Mark Paetzel; Franck Danel; L de Castro; SC Mosimann; Malcolm G P Page; Natalie C J Strynadka
Crystal structure of the class D beta-lactamase OXA-10.
Nature structural biology 2000;7(10):918-25.
2000: G Rossé; E Kueng; Malcolm G P Page; Vesna Schauer-Vukasinovic; Thomas Giller; H W Lahm; Peter Hunziker; D Schlatter
Rapid identification of substrates for novel proteases using a combinatorial peptide library.
Journal of combinatorial chemistry 2000;2(5):461-6.
2000: Christian M Apfel; D W Banner; Daniel Bur; M Dietz; T Hirata; Christian Hubschwerlen; Hans H Locher; Malcolm G P Page; W Pirson; G Rossé; Jean-Luc Specklin
Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents.
Journal of medicinal chemistry 2000;43(12):2324-31.
2000: G J Chen; N Qiu; C Karrer; Patrick Caspers; Malcolm G P Page
Restriction site-free insertion of PCR products directionally into vectors.
BioTechniques 2000;28(3):498-500, 504-5.
1999: Alan-Shaun Wilkinson; S Ward; Malgosia Kania; Malcolm G P Page; Christopher W Wharton
Multiple conformations of the acylenzyme formed in the hydrolysis of methicillin by Citrobacter freundii beta-lactamase: a time-resolved FTIR spectroscopic study.
Biochemistry 1999;38(13):3851-6.
1999: M Hennig; Glenn E Dale; Allan D'Arcy; Franck Danel; S Fischer; C P Gray; S Jolidon; F Müller; Malcolm G P Page; P Pattison; Christian Oefner
The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.
Journal of molecular biology 1999;287(2):211-9.
1999: RS Chittock; S Ward; Alan-Shaun Wilkinson; Patrick Caspers; B Mensch; Malcolm G P Page; Christopher W Wharton
Hydrogen bonding and protein perturbation in beta-lactam acyl-enzymes of Streptococcus pneumoniae penicillin-binding protein PBP2x.
The Biochemical journal 1999;338 ( Pt 1)():153-9.
1998: Christian Hubschwerlen; Peter Angehrn; K Gubernator; Malcolm G P Page; Jean-Luc Specklin
Structure-based design of beta-lactamase inhibitors. 2. Synthesis and evaluation of bridged sulfactams and oxamazins.
Journal of medicinal chemistry 1998;41(21):3972-5.
1998: I Heinze-Krauss; Peter Angehrn; R L Charnas; K Gubernator; E M Gutknecht; Christian Hubschwerlen; Malgosia Kania; Christian Oefner; Malcolm G P Page; S Sogabe; Jean-Luc Specklin; F Winkler
Structure-based design of beta-lactamase inhibitors. 1. Synthesis and evaluation of bridged monobactams.
Journal of medicinal chemistry 1998;41(21):3961-71.
1998: M Hennig; Allan D'Arcy; I C Hampele; Malcolm G P Page; Christian Oefner; Glenn E Dale
Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nature structural biology 1998;5(5):357-62.
1997: I C Hampele; Allan D'Arcy; Glenn E Dale; Dirk Kostrewa; J Nielsen; Christian Oefner; Malcolm G P Page; Hans-Joachim Schönfeld; D Stüber; Rudolf L Then
Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
Journal of molecular biology 1997;268(1):21-30.
1997: Glenn E Dale; C Broger; Allan D'Arcy; P G Hartman; R DeHoogt; S Jolidon; I Kompis; Alexander Michael Labhardt; Hanno Langen; Hans H Locher; Malcolm G P Page; D Stüber; Rudolf L Then; B Wipf; Christian Oefner
A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance.
Journal of molecular biology 1997;266(1):23-30.
1996: H G Richter; Peter Angehrn; Christian Hubschwerlen; Malgosia Kania; Malcolm G P Page; Jean-Luc Specklin; F K Winkler
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Journal of medicinal chemistry 1996;39(19):3712-22.
1996: I Heinze-Krauss; Peter Angehrn; P Guerry; P Hebeisen; Christian Hubschwerlen; I Kompis; Malcolm G P Page; H G Richter; V Runtz; H Stalder; U Weiss; C C Wei
Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci.
Journal of medicinal chemistry 1996;39(9):1864-71.
1995: Glenn E Dale; H Langen; Malcolm G P Page; Rudolf L Then; D Stüber
Cloning and characterization of a novel, plasmid-encoded trimethoprim-resistant dihydrofolate reductase from Staphylococcus haemolyticus MUR313.
Antimicrobial agents and chemotherapy 1995;39(9):1920-4.
1995: A Dubus; Staffan Normark; Malgosia Kania; Malcolm G P Page
Role of asparagine 152 in catalysis of beta-lactam hydrolysis by Escherichia coli AmpC beta-lactamase studied by site-directed mutagenesis.
Biochemistry 1995;34(23):7757-64.
1995: Glenn E Dale; C Broger; P G Hartman; H Langen; Malcolm G P Page; Rudolf L Then; D Stüber
Characterization of the gene for the chromosomal dihydrofolate reductase (DHFR) of Staphylococcus epidermidis ATCC 14990: the origin of the trimethoprim-resistant S1 DHFR from Staphylococcus aureus?
Journal of bacteriology 1995;177(11):2965-70.
1994: A Dubus; Staffan Normark; Malgosia Kania; Malcolm G P Page
The role of tyrosine 150 in catalysis of beta-lactam hydrolysis by AmpC beta-lactamase from Escherichia coli investigated by site-directed mutagenesis.
Biochemistry 1994;33(28):8577-86.