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Michael Pagliassotti

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Angela M Nivala; Melinda Frye; Christopher L Gentile; Lauren Reese; Michael J Pagliassotti
Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of Soybean and Lard Oil in rats.
Kimberly A Cox-York; Michael J Pagliassotti; Teresa A Sharp; Sarah A Stotz; Daniel H Bessesen; Tracy J Horton
The effects of sex, metabolic syndrome and exercise on postprandial lipemia.
Dong Wang; Yuren Wei; Melinda Frye; Christopher L Gentile; Michael J Pagliassotti
Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10.

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All Publications

2013: Angela M Nivala; Melinda Frye; Christopher L Gentile; Lauren Reese; Michael J Pagliassotti
Fatty acid-mediated endoplasmic reticulum stress in vivo: differential response to the infusion of Soybean and Lard Oil in rats.
Metabolism: clinical and experimental 2013;62(5):753-60.
2013: Kimberly A Cox-York; Michael J Pagliassotti; Teresa A Sharp; Sarah A Stotz; Daniel H Bessesen; Tracy J Horton
The effects of sex, metabolic syndrome and exercise on postprandial lipemia.
Metabolism: clinical and experimental 2013;62(2):244-54.
2013: Dong Wang; Yuren Wei; Melinda Frye; Christopher L Gentile; Michael J Pagliassotti
Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10.
Journal of nutrition and metabolism 2013;2013():514206.
2012: Michael J Pagliassotti
Endoplasmic reticulum stress in nonalcoholic fatty liver disease.
Annual review of nutrition 2012;32():17-33.
2012: Kimberly M Jeckel; Christopher M Mulligan; Michael J Pagliassotti; D N Rao Veeramachaneni; Gerrit J Bouma; Phillip L Chapman; Adam J Chicco; Lindsay A Ferguson; Jennifer R Hegarty; Melinda A Frye
Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats.
PloS one 2012;7(12):e51994.
2011: Christopher L Gentile; Jon C Gonzales; Hua Jiang; Angela M Nivala; David J Orlicky; Michael J Pagliassotti; Dennis R Petersen; Kyle T Pfaffenbach; Dong Wang; Yuren Wei; Kenneth N Maclean
Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(6):R1710-22.
2011: Christopher L Gentile; Melinda Frye; Michael J Pagliassotti
Endoplasmic reticulum stress and the unfolded protein response in nonalcoholic fatty liver disease.
Antioxidants & redox signaling 2011;15(2):505-21.
2011: William L Holland; Benjamin T Bikman; Li-Ping Wang; Guan Yuguang; Katherine M Sargent; Sarada Bulchand; Trina A Knotts; Guanghou Shui; Deborah J Clegg; Markus R Wenk; Michael J Pagliassotti; Philipp E Scherer; Scott A Summers
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
The Journal of clinical investigation 2011;121(5):1858-70.
2011: Kimberly M Jeckel; Kelsey E Miller; Melissa L Miller; Christopher M Mulligan; Michael J Pagliassotti; Phillip L Chapman; Adam J Chicco; Paul H Falcone; Melinda A Frye
The role of dietary fatty acids in predicting myocardial structure in fat-fed rats.
Lipids in health and disease 2011;10():92.
2011: Stacy L Schmidt; Matthew S Hickey; Kathryn M Koblenz; Holly Klamer; Maria F Botero; Kyle T Pfaffenbach; Michael J Pagliassotti; Christopher L Melby
Cardiometabolic plasticity in response to a short-term diet and exercise intervention in young Hispanic and nonHispanic white adults.
PloS one 2011;6(2):e16987.
2011: Christopher L Gentile; Melinda A Frye; Michael J Pagliassotti
Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease.
BioFactors (Oxford, England) 2011;37(1):8-16.
2010: C L Gentile; Dong Wang; K T Pfaffenbach; Roger Cox; Yuren Wei; Michael J Pagliassotti
Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin.
Molecular and cellular biochemistry 2010;344(1-2):99-107.
2010: Warren H Capell; Isabel R Schlaepfer; Pamela Wolfe; Peter A Watson; Daniel H Bessesen; Michael J Pagliassotti; Robert H Eckel
Fatty acids increase glucose uptake and metabolism in C2C12 myoblasts stably transfected with human lipoprotein lipase.
American journal of physiology. Endocrinology and metabolism 2010;299(4):E576-83.
2010: Kyle T Pfaffenbach; Christopher L Gentile; Angela M Nivala; Dong Wang; Yuren Wei; Michael J Pagliassotti
Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death.
American journal of physiology. Endocrinology and metabolism 2010;298(5):E1027-35.
2009: Yuren Wei; Dong Wang; Christopher L Gentile; Michael J Pagliassotti
Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells.
Molecular and cellular biochemistry 2009;331(1-2):31-40.
2008: Christopher L Gentile; Michael J Pagliassotti
The endoplasmic reticulum as a potential therapeutic target in nonalcoholic fatty liver disease.
Current opinion in investigational drugs (London, England : 2000) 2008;9(10):1084-8.
2008: J C Gonzales; C L Gentile; K T Pfaffenbach; Yuren Wei; Dong Wang; Michael J Pagliassotti
Chemical induction of the unfolded protein response in the liver increases glucose production and is activated during insulin-induced hypoglycaemia in rats.
Diabetologia 2008;51(10):1920-9.
2008: Christopher L Gentile; Michael J Pagliassotti
The role of fatty acids in the development and progression of nonalcoholic fatty liver disease.
The Journal of nutritional biochemistry 2008;19(9):567-76.
2007: Yuren Wei; Dong Wang; Michael J Pagliassotti
Saturated fatty acid-mediated endoplasmic reticulum stress and apoptosis are augmented by trans-10, cis-12-conjugated linoleic acid in liver cells.
Molecular and cellular biochemistry 2007;303(1-2):105-13.
2007: Michael J Pagliassotti; Yuren Wei; Dong Wang
Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity.
Endocrinology 2007;148(7):3338-45.
2007: Yuren Wei; Dong Wang; Farran Topczewski; Michael J Pagliassotti
Fructose-mediated stress signaling in the liver: implications for hepatic insulin resistance.
The Journal of nutritional biochemistry 2007;18(1):1-9.
2006: Yuren Wei; Dong Wang; Farran Topczewski; Michael J Pagliassotti
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells.
American journal of physiology. Endocrinology and metabolism 2006;291(2):E275-81.
2006: Dong Wang; Yuren Wei; Michael J Pagliassotti
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis.
Endocrinology 2006;147(2):943-51.
2006: Dong Wang; Yuren Wei; Dieter Schmoll; Kenneth N Maclean; Michael J Pagliassotti
Endoplasmic reticulum stress increases glucose-6-phosphatase and glucose cycling in liver cells.
Endocrinology 2006;147(1):350-8.
2005: Michael E Bizeau; Michael J Pagliassotti
Hepatic adaptations to sucrose and fructose.
Metabolism: clinical and experimental 2005;54(9):1189-201.
2005: Yuren Wei; Dong Wang; Michael J Pagliassotti
Fructose selectively modulates c-jun N-terminal kinase activity and insulin signaling in rat primary hepatocytes.
The Journal of nutrition 2005;135(7):1642-6.
2005: Liping Qiao; Paul S Maclean; Jerome Schaack; David J Orlicky; Christian Darimont; Michael J Pagliassotti; Jacob E Friedman; Jianhua Shao
C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer.
Diabetes 2005;54(6):1744-54.
2005: Jianhua Shao; Liping Qiao; Rachel C Janssen; Michael J Pagliassotti; Jacob E Friedman
Chronic hyperglycemia enhances PEPCK gene expression and hepatocellular glucose production via elevated liver activating protein/liver inhibitory protein ratio.
Diabetes 2005;54(4):976-84.
2005: Livia Puljak; Michael J Pagliassotti; Yuren Wei; Ishtiaq Qadri; Vinay Parameswara; Victoria Esser; J Gregory Fitz; Gordan Kilic
Inhibition of cellular responses to insulin in a rat liver cell line. A role for PKC in insulin resistance.
The Journal of physiology 2005;563(Pt 2):471-82.
2004: Yuren Wei; Michael J Pagliassotti
Hepatospecific effects of fructose on c-jun NH2-terminal kinase: implications for hepatic insulin resistance.
American journal of physiology. Endocrinology and metabolism 2004;287(5):E926-33.
2004: Sylvain Cardin; Michael J Pagliassotti; Mary Courtney Moore; Dale S Edgerton; Margaret Lautz; Ben Farmer; Doss W Neal; Alan D Cherrington
Vagal cooling and concomitant portal norepinephrine infusion do not reduce net hepatic glucose uptake in conscious dogs.
American journal of physiology. Regulatory, integrative and comparative physiology 2004;287(4):R742-8.
2004: Yuren Wei; Michael E Bizeau; Michael J Pagliassotti
An acute increase in fructose concentration increases hepatic glucose-6-phosphatase mRNA via mechanisms that are independent of glycogen synthase kinase-3 in rats.
The Journal of nutrition 2004;134(3):545-51.
2003: Hiroshi Yamashita; Jianhua Shao; Liping Qiao; Michael J Pagliassotti; Jacob E Friedman
Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice.
Pediatric research 2003;53(3):411-8.
2003: Michael J Pagliassotti; Yuren Wei; Michael E Bizeau
Glucose-6-phosphatase activity is not suppressed but the mRNA level is increased by a sucrose-enriched meal in rats.
The Journal of nutrition 2003;133(1):32-7.
2002: Tracy J Horton; S Renee Commerford; Michael J Pagliassotti; Daniel H Bessesen
Postprandial leg uptake of triglyceride is greater in women than in men.
American journal of physiology. Endocrinology and metabolism 2002;283(6):E1192-202.
2002: S Renee Commerford; Jennifer B Ferniza; Michael E Bizeau; Jeffrey S Thresher; Wayne T Willis; Michael J Pagliassotti
Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats.
American journal of physiology. Endocrinology and metabolism 2002;283(3):E545-55.
2002: Michael J Pagliassotti; Jione Kang; Jeffrey S Thresher; Chin K Sung; Michael E Bizeau
Elevated basal PI 3-kinase activity and reduced insulin signaling in sucrose-induced hepatic insulin resistance.
American journal of physiology. Endocrinology and metabolism 2002;282(1):E170-6.
2001: Michael E Bizeau; Jeffrey S Thresher; Michael J Pagliassotti
Sucrose diets increase glucose-6-phosphatase and glucose release and decrease glucokinase in hepatocytes.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;91(5):2041-6.
2001: S Renee Commerford; Michael E Bizeau; H McRae; A Jampolis; Jeffrey S Thresher; Michael J Pagliassotti
Hyperglycemia compensates for diet-induced insulin resistance in liver and skeletal muscle of rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(5):R1380-9.
2001: Michael E Bizeau; C Short; Jeffrey S Thresher; S Renee Commerford; Wayne T Willis; Michael J Pagliassotti
Increased pyruvate flux capacities account for diet-induced increases in gluconeogenesis in vitro.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;281(2):R427-33.
2001: S Renee Commerford; Michael J Pagliassotti; C L Melby; Yuren Wei; James O Hill
Inherent capacity for lipogenesis or dietary fat retention is not increased in obesity-prone rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(6):R1680-7.
2001: Michael E Bizeau; Jeffrey S Thresher; Michael J Pagliassotti
A high-sucrose diet increases gluconeogenic capacity in isolated periportal and perivenous rat hepatocytes.
American journal of physiology. Endocrinology and metabolism 2001;280(5):E695-702.
2000: Jeffrey S Thresher; DA Podolin; Yuren Wei; Robert S Mazzeo; Michael J Pagliassotti
Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(4):R1334-40.
2000: S Renee Commerford; Michael J Pagliassotti; C L Melby; Yuren Wei; Ellis C Gayles; James O Hill
Fat oxidation, lipolysis, and free fatty acid cycling in obesity-prone and obesity-resistant rats.
American journal of physiology. Endocrinology and metabolism 2000;279(4):E875-85.
2000: Wayne T Willis; M R Jackman; Michael E Bizeau; Michael J Pagliassotti; Jeffrey R Hazel
Hyperthermia impairs liver mitochondrial function in vitro.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(5):R1240-6.
2000: E E Smith; Virginia L Ferguson; Steven J Simske; Ellis C Gayles; Michael J Pagliassotti
Effects of high fat or high sucrose diets on rat femora mechanical and compositional properties.
Biomedical sciences instrumentation 2000;36():385-90.
2000: Michael J Pagliassotti; Ellis C Gayles; DA Podolin; Yuren Wei; CL Morin
Developmental stage modifies diet-induced peripheral insulin resistance in rats.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;278(1):R66-73.
1999: Po-Shiuan Hsieh; Mary Courtney Moore; B Marshall; Michael J Pagliassotti; B Shay; D Szurkus; Doss W Neal; Alan D Cherrington
The head arterial glucose level is not the reference site for generation of the portal signal in conscious dogs.
The American journal of physiology 1999;277(4 Pt 1):E678-84.
1999: DA Podolin; Yuren Wei; Michael J Pagliassotti
Effects of a high-fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;86(4):1374-80.
1998: CL Morin; Ellis C Gayles; DA Podolin; Yuren Wei; Mei Xu; Michael J Pagliassotti
Adipose tissue-derived tumor necrosis factor activity correlates with fat cell size but not insulin action in aging rats.
Endocrinology 1998;139(12):4998-5005.
1998: Tracy J Horton; Michael J Pagliassotti; K Hobbs; J O Hill
Fuel metabolism in men and women during and after long-duration exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;85(5):1823-32.
1998: Mary Courtney Moore; Paul J Flakoll; Po-Shiuan Hsieh; Michael J Pagliassotti; Doss W Neal; Michael Monohan; C Venable; Alan D Cherrington
Hepatic glucose disposition during concomitant portal glucose and amino acid infusions in the dog.
The American journal of physiology 1998;274(5 Pt 1):E893-902.
1998: DA Podolin; Eileen Sutherland; Mieko Iwahashi; Francis R Simon; Michael J Pagliassotti
A high-sucrose diet alters the lipid composition and fluidity of liver sinusoidal membranes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1998;30(4):195-9.
1998: DA Podolin; Ellis C Gayles; Yuren Wei; Jeffrey S Thresher; Michael J Pagliassotti
Menhaden oil prevents but does not reverse sucrose-induced insulin resistance in rats.
The American journal of physiology 1998;274(3 Pt 2):R840-8.
1997: PA Jackson; Michael J Pagliassotti; Masakazu Shiota; Doss W Neal; Sylvain Cardin; Alan D Cherrington
Effects of vagal blockade on the counterregulatory response to insulin-induced hypoglycemia in the dog.
The American journal of physiology 1997;273(6 Pt 1):E1178-88.
1997: CL Morin; Robert H Eckel; T Marcel; Michael J Pagliassotti
High fat diets elevate adipose tissue-derived tumor necrosis factor-alpha activity.
Endocrinology 1997;138(11):4665-71.
1997: Michael J Pagliassotti; Ellis C Gayles; James O Hill
Fat and energy balance.
Annals of the New York Academy of Sciences 1997;827():431-48.
1997: CL Morin; Michael J Pagliassotti; D Windmiller; Robert H Eckel
Adipose tissue-derived tumor necrosis factor-alpha activity is elevated in older rats.
The journals of gerontology. Series A, Biological sciences and medical sciences 1997;52(4):B190-5.
1997: Tracy J Horton; Ellis C Gayles; PA Prach; TA Koppenhafer; Michael J Pagliassotti
Female rats do not develop sucrose-induced insulin resistance.
The American journal of physiology 1997;272(5 Pt 2):R1571-6.
1997: Michael J Pagliassotti; Tracy J Horton; Ellis C Gayles; TA Koppenhafer; T D Rosenzweig; James O Hill
Reduced insulin suppression of glucose appearance is related to susceptibility to dietary obesity in rats.
The American journal of physiology 1997;272(4 Pt 2):R1264-70.
1997: Michael J Pagliassotti; PA Prach
Increased net hepatic glucose output from gluconeogenic precursors after high-sucrose diet feeding in male rats.
The American journal of physiology 1997;272(2 Pt 2):R526-31.
1997: Ellis C Gayles; Michael J Pagliassotti; PA Prach; TA Koppenhafer; James O Hill
Contribution of energy intake and tissue enzymatic profile to body weight gain in high-fat-fed rats.
The American journal of physiology 1997;272(1 Pt 2):R188-94.
1996: Michael J Pagliassotti; P A Prach; T A Koppenhafer; D A Pan
Changes in insulin action, triglycerides, and lipid composition during sucrose feeding in rats.
The American journal of physiology 1996;271(5 Pt 2):R1319-26.
1996: Mary Courtney Moore; L Rossetti; Michael J Pagliassotti; M Monahan; C Venable; Doss Neal; Alan D Cherrington
Neural and pancreatic influences on net hepatic glucose uptake and glycogen synthesis.
The American journal of physiology 1996;271(2 Pt 1):E215-22.
1996: Michael J Pagliassotti; L C Holste; Mary Courtney Moore; Doss W Neal; Alan D Cherrington
Comparison of the time courses of insulin and the portal signal on hepatic glucose and glycogen metabolism in the conscious dog.
The Journal of clinical investigation 1996;97(1):81-91.
1995: Michael J Pagliassotti; D Pan; P Prach; T Koppenhafer; L Storlien; James O Hill
Tissue oxidative capacity, fuel stores and skeletal muscle fatty acid composition in obesity-prone and obesity-resistant rats.
Obesity research 1995;3(5):459-64.
1995: Michael J Pagliassotti; P A Prach
Quantity of sucrose alters the tissue pattern and time course of insulin resistance in young rats.
The American journal of physiology 1995;269(3 Pt 2):R641-6.
1994: Michael J Pagliassotti; Susan M Knobel; K A Shahrokhi; A M Manzo; James O Hill
Time course of adaptation to a high-fat diet in obesity-resistant and obesity-prone rats.
The American journal of physiology 1994;267(3 Pt 2):R659-64.
1994: DA Podolin; Michael J Pagliassotti; T T Gleeson; Robert S Mazzeo
Influence of endurance training on the age-related decline in hepatic glyconeogenesis.
Mechanisms of ageing and development 1994;75(1):81-93.
1994: Michael J Pagliassotti; K A Shahrokhi; M Moscarello
Involvement of liver and skeletal muscle in sucrose-induced insulin resistance: dose-response studies.
The American journal of physiology 1994;266(5 Pt 2):R1637-44.
1994: Mary Courtney Moore; Michael J Pagliassotti; Richard E Goldstein; J Asher; J Murrell; Doss Neal; Alan D Cherrington
The effect of the hepatic nerves on the disposition of a mixed meal by conscious dogs.
JPEN. Journal of parenteral and enteral nutrition 1994;18(3):248-55.
1994: Mary Courtney Moore; Michael J Pagliassotti; L L Swift; J Asher; J Murrell; Doss Neal; Alan D Cherrington
Disposition of a mixed meal by the conscious dog.
The American journal of physiology 1994;266(4 Pt 1):E666-75.
1993: Mary Courtney Moore; Michael J Pagliassotti; David H Wasserman; R Goldstein; J Asher; Doss W Neal; Alan D Cherrington
Hepatic denervation alters the transition from the fed to the food-deprived state in conscious dogs.
The Journal of nutrition 1993;123(10):1739-46.
1993: Mary Courtney Moore; G I Shulman; A Giaccari; Michael J Pagliassotti; G Cline; Doss Neal; L Rossetti; Alan D Cherrington
Effect of hepatic nerves on disposition of an intraduodenal glucose load.
The American journal of physiology 1993;265(3 Pt 1):E487-96.
1993: Michael J Pagliassotti; K A Shahrokhi; James O Hill
Skeletal muscle glucose metabolism in obesity-prone and obesity-resistant rats.
The American journal of physiology 1993;264(6 Pt 2):R1224-8.
1993: Michael J Pagliassotti; C A Colburn; Mary Courtney Moore; Doss W Neal; S J Dominianni; T W Stephens; Alan D Cherrington
Regulation of net hepatic substrate balance by phenacylimidazolium ions in the conscious dog.
Diabetes research (Edinburgh, Scotland) 1993;22(3):123-33.
1992: Michael J Pagliassotti; Mary Courtney Moore; Doss W Neal; Alan D Cherrington
Insulin is required for the liver to respond to intraportal glucose delivery in the conscious dog.
Diabetes 1992;41(10):1247-56.
1992: B Adkins-Marshall; Michael J Pagliassotti; J R Asher; Cynthia C Connolly; Doss W Neal; Phillip E Williams; S R Myers; G K Hendrick; R B Adkins; Alan D Cherrington
Role of hepatic nerves in response of liver to intraportal glucose delivery in dogs.
The American journal of physiology 1992;262(5 Pt 1):E679-86.
1992: Michael J Pagliassotti; Alan D Cherrington
Regulation of net hepatic glucose uptake in vivo.
Annual review of physiology 1992;54():847-60.
1991: Michael J Pagliassotti; S R Myers; Mary Courtney Moore; Doss W Neal; Alan D Cherrington
Magnitude of negative arterial-portal glucose gradient alters net hepatic glucose balance in conscious dogs.
Diabetes 1991;40(12):1659-68.
1991: David H Wasserman; Cynthia C Connolly; Michael J Pagliassotti
Regulation of hepatic lactate balance during exercise.
Medicine and science in sports and exercise 1991;23(8):912-9.
1991: Mary Courtney Moore; Alan D Cherrington; G Cline; Michael J Pagliassotti; E M Jones; Doss W Neal; C Badet; G I Shulman
Sources of carbon for hepatic glycogen synthesis in the conscious dog.
The Journal of clinical investigation 1991;88(2):578-87.
1991: Michael J Pagliassotti; C Tarumi; Doss W Neal; Alan D Cherrington
Hepatic denervation alters the disposition of an enteral glucose load in conscious dogs.
The Journal of nutrition 1991;121(8):1255-61.
1991: Alan D Cherrington; Michael J Pagliassotti; S R Myers; B Adkins-Marshall; Owen P McGuinness
Factors which regulate net hepatic glucose uptake in vivo.
JPEN. Journal of parenteral and enteral nutrition 1991;15(3):71S-73S.