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Giuseppe Paglietti

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Paola Corona; Antonio Carta; Andrea Cavalli; Stefania Ferrari; Federica Gibellini; Davide Guerrieri; Shreedhara Gupta; Véronique Hannaert; Mario Loriga; Rosaria Luciani; Paul A M Michels; Erika Nerini; Giuseppe Paglietti; Puneet Saxena; Paola M Costi
Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.
Gabriella Vitale; Antonio Carta; Paola Corona; Pamela Farci; Gabriele Giliberti; Mario Loriga; Maria Elena Marongiu; Giuseppe Paglietti; Giuseppina Sanna; Paolo La Colla
5-acetyl-2-arylbenzimidazoles as antiviral agents. Part 4.
Gaetano Marverti; Alessio Ligabue; Davide Guerrieri; Giuseppe Paglietti; Sandra Piras; Maria P Costi; Davide Farina; Chiara Frassineti; Maria G Monti; Maria S Moruzzi
Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.

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All Publications

2012: Paola Corona; Antonio Carta; Andrea Cavalli; Stefania Ferrari; Federica Gibellini; Davide Guerrieri; Shreedhara Gupta; Véronique Hannaert; Mario Loriga; Rosaria Luciani; Paul A M Michels; Erika Nerini; Giuseppe Paglietti; Puneet Saxena; Paola M Costi
Structure-based selectivity optimization of piperidine-pteridine derivatives as potent Leishmania pteridine reductase inhibitors.
Journal of medicinal chemistry 2012;55(19):8318-29.
2012: Gabriella Vitale; Antonio Carta; Paola Corona; Pamela Farci; Gabriele Giliberti; Mario Loriga; Maria Elena Marongiu; Giuseppe Paglietti; Giuseppina Sanna; Paolo La Colla
5-acetyl-2-arylbenzimidazoles as antiviral agents. Part 4.
European journal of medicinal chemistry 2012;53():83-97.
2010: Gaetano Marverti; Alessio Ligabue; Davide Guerrieri; Giuseppe Paglietti; Sandra Piras; Maria P Costi; Davide Farina; Chiara Frassineti; Maria G Monti; Maria S Moruzzi
Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.
Gynecologic oncology 2010;117(2):202-10.
2010: Michele Tonelli; Matteo Simone; Bruno Tasso; Federica Novelli; Vito Boido; Fabio Sparatore; Giuseppe Paglietti; Pricl Sabrina; Gabriele Giliberti; Sylvain Blois; Cristina Ibba; Giuseppina Sanna; Roberta Loddo; Paolo La Colla
Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives.
Bioorganic & medicinal chemistry 2010;18(8):2937-53.
2010: Gabriella Vitale; Paola Corona; Mario Loriga; Antonio Carta; Giuseppe Paglietti; Cristina Ibba; Gabriele Giliberti; Roberta Loddo; Esther Marongiu; Paolo La Colla
Styrylbenzimidazoles. Synthesis and biological activity - part 3.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2010;6(2):70-8.
2009: Gabriella Vitale; Paola Corona; Mario Loriga; Antonio Carta; Giuseppe Paglietti; Paolo La Colla; Bernardetta Busonera; Esther Marongiu; David Collu; Roberta Loddo
2-Arylbenzimidazoles as antiviral and antiproliferative agents--Part 2.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2009;5(6):507-16.
2009: Paola Corona; Antonio Carta; Mario Loriga; Gabriella Vitale; Giuseppe Paglietti
Synthesis and in vitro antitumor activity of new quinoxaline derivatives.
European journal of medicinal chemistry 2009;44(4):1579-91.
2008: Michele Tonelli; Giuseppe Paglietti; Vito Boido; Fabio Sparatore; Fabio Marongiu; Esther Marongiu; Paolo La Colla; Roberta Loddo
Antiviral activity of benzimidazole derivatives. I. Antiviral activity of 1-substituted-2-[(benzotriazol-1/2-yl)methyl]benzimidazoles.
Chemistry & biodiversity 2008;5(11):2386-401.
2008: G Vitale; Antonio Carta; Mario Loriga; Giuseppe Paglietti; Paolo La Colla; Bernardetta Busonera; D Collu; Roberta Loddo
2-Arylbenzimidazoles as antiviral and antiproliferative agents. Part 1.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2008;4(6):605-15.
2008: Antonio Carta; Sandra Piras; Giuseppe Paglietti; Pricl Sabrina; Paolo La Colla; Bernardetta Busonera; Roberta Loddo
2(3)-Aryl-thio(oxy)-methylquinoxaline derivatives: a new class of P-glycoprotein-mediated drug efflux inhibitors.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2008;4(3):194-205.
2008: Antonio Cavazzuti; Giuseppe Paglietti; William N Hunter; Francisco Gamarro; Sandra Piras; Mario Loriga; Sergio Allecca; Paola Corona; Karen McLuskey; Lindsay Tulloch; Federica Gibellini; Stefania Ferrari; M Paola Costi
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(5):1448-53.
2008: Paola Corona; Mario Loriga; M Paola Costi; Stefania Ferrari; Giuseppe Paglietti
Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities.
European journal of medicinal chemistry 2008;43(1):189-203.
2007: Antonio Carta; Mario Loriga; Sandra Piras; Giuseppe Paglietti; Marco Ferrone; Maurizio Fermeglia; Pricl Sabrina; Paolo La Colla; Gabriella Collu; T Sanna; Roberta Loddo
Synthesis and anti-picornaviridae in vitro activity of a new class of helicase inhibitors the N,N'-bis[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl] alkyldicarboxamides.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2007;3(6):520-32.
2007: Antonio Carta; Michele Palomba; Giuseppe Paglietti; Paola Molicotti; Bianca Paglietti; Sara Cannas; Stefania Zanetti
[1,2,3]Triazolo[4,5-h]quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains.
Bioorganic & medicinal chemistry letters 2007;17(17):4791-4.
2007: Antonio Carta; Mario Loriga; Giuseppe Paglietti; Marco Ferrone; Maurizio Fermeglia; Pricl Sabrina; Tiziana Sanna; Cristina Ibba; Paolo La Colla; Roberta Loddo
Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against single-stranded positive-sense RNA genome viruses.
Bioorganic & medicinal chemistry 2007;15(5):1914-27.
2006: Antonio Carta; Giovanni Loriga; Sandra Piras; Giuseppe Paglietti; Marco Ferrone; Maurizio Fermeglia; Pricl Sabrina; Paolo La Colla; Barbara Secci; Gabriella Collu; Roberta Loddo
Synthesis and in vitro evaluation of the anti-viral activity of N-[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl]alkylcarboxamides.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2006;2(6):577-89.
2006: Antonio Carta; Sandra Piras; Giovanni Loriga; Giuseppe Paglietti
Chemistry, biological properties and SAR analysis of quinoxalinones.
Mini reviews in medicinal chemistry 2006;6(11):1179-200.
2006: Paola Corona; Gabriella Vitale; Mario Loriga; Giuseppe Paglietti; Paolo La Colla; Gabriella Collu; Giuseppina Sanna; Roberta Loddo
4-Substituted anilino imidazo[1,2-a] and triazolo[4,3-a]quinoxalines. Synthesis and evaluation of in vitro biological activity.
European journal of medicinal chemistry 2006;41(9):1102-7.
2006: Antonio Carta; Mario Loriga; Sandra Piras; Giuseppe Paglietti; Paolo La Colla; Bernardetta Busonera; Gabriella Collu; Roberta Loddo
Synthesis of variously substituted 3-phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2006;2(2):113-22.
2005: Stefania Zanetti; Leonardo A Sechi; Paola Molicotti; Sara Cannas; Alessandra Bua; Antonella Deriu; Antonio Carta; Giuseppe Paglietti
In vitro activity of new quinoxalin 1,4-dioxide derivatives against strains of Mycobacterium tuberculosis and other mycobacteria.
International journal of antimicrobial agents 2005;25(2):179-81.
2004: Sandra Piras; Mario Loriga; Giuseppe Paglietti
Quinoxaline chemistry. Part XVII. Methyl [4-(substituted 2-quinoxalinyloxy) phenyl] acetates and ethyl N-([4-(substituted 2-quinoxalinyloxy) phenyl] acetyl) glutamates analogs of methotrexate: synthesis and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 2004;59(3):185-94.
2004: Antonio Carta; Mario Loriga; Giuseppe Paglietti; Antonella Mattana; Pier Luigi Fiori; Paola Mollicotti; Leonardo A Sechi; Stefania Zanetti
Synthesis, anti-mycobacterial, anti-trichomonas and anti-candida in vitro activities of 2-substituted-6,7-difluoro-3-methylquinoxaline 1,4-dioxides.
European journal of medicinal chemistry 2004;39(2):195-203.
2003: Sergio Alleca; Paola Corona; Mario Loriga; Giuseppe Paglietti; Roberta Loddo; Valeria Mascia; Bernardetta Busonera; Paolo La Colla
Quinoxaline chemistry. Part 16. 4-substituted anilino and 4-substituted phenoxymethyl pyrrolo[1,2-a]quinoxalines and N-[4-(pyrrolo[1,2-a]quinoxalin-4-yl)amino and hydroxymethyl]benzoyl glutamates. Synthesis and evaluation of in vitro biological activity.
Farmaco (Società chimica italiana : 1989) 2003;58(9):639-50.
2003: Mario Loriga; Sandra Piras; Giuseppe Paglietti; M Paola Costi; Alberto Venturelli
Quinoxaline chemistry. Part 15. 4-[2-Quinoxalylmethylenimino]-benzoylglutamates and -benzoates, 4-[2-quinoxalylmethyl-N-methylamino]-benzoylglutamates as analogues of classical antifolate agents. Synthesis, elucidation of structures and in vitro evaluation of antifolate and anticancer activities.
Farmaco (Società chimica italiana : 1989) 2003;58(1):51-61.
2002: Antonio Carta; Giuseppe Paglietti; Mohammad E Rahbar Nikookar; Paolo Sanna; Leonardo A Sechi; Stefania Zanetti
Novel substituted quinoxaline 1,4-dioxides with in vitro antimycobacterial and anticandida activity.
European journal of medicinal chemistry 2002;37(5):355-66.
2002: Sandra Piras; Mario Loriga; Giuseppe Paglietti
Quinoxaline chemistry. Part 14. 4-(2-Quinoxalylamino)-phenylacetates and 4-(2-quinoxalylamino)-phenylacetyl-L-glutamates as analogues--homologues of classical antifolate agents. Synthesis and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 2002;57(1):1-8.
2001: Gérard A Pinna; Maria A Pirisi; Giuseppe E Grella; L Gherardini; Jean-Mario Mussinu; Giuseppe Paglietti; Anna Maria Ferrari; Giulio Rastelli
Synthesis and cytotoxicity of bis(benzo[g]indole-3-carboxamides) and related compounds.
Archiv der Pharmazie 2001;334(11):337-44.
2000: Paola Corona; Gabriella Vitale; Mario Loriga; Giuseppe Paglietti
Quinoxaline chemistry. Part 13: 3-Carboxy-2-benzylamino-substituted quinoxalines and N-[4-[(3-carboxyquinoxalin-2-yl) aminomethyl]benzoyl]-L-glutamates: synthesis and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 2000;55(2):77-86.
1998: Gabriella Vitale; Paola Corona; Mario Loriga; Giuseppe Paglietti
Quinoxaline chemistry. Part 12. 3-Carboxy-2[phenoxy]-6(7)substituted quinoxalines and N-[4-(6(7) substituted-3-carboxyquinoxalin-2-yl)hydroxy] benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 1998;53(8-9):594-601.
1998: Paola Corona; Gabriella Vitale; Mario Loriga; Giuseppe Paglietti; M Paola Costi
Quinoxaline chemistry. Part 11. 3-Phenyl-2[phenoxy- and phenoxymethyl]-6(7) or 6,8-substituted quinoxalines and N-[4-(6(7)-substituted or 6,8-disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl] benzoylglutamates. Synthesis and evaluation of in vitro anticancer activity and enzymatic inhibitory activity against dihydrofolate reductase and thymidylate synthase.
Farmaco (Società chimica italiana : 1989) 1998;53(7):480-93.
1998: Gérard A Pinna; Maria A Pirisi; Mario Sechi; Giuseppe Paglietti
Synthesis and in vitro anticancer activity evaluation of biscarbamic esters of 2,3-bis(hydroxymethyl)-1-methyl-7- and 7,8-substituted-benzo[g]indoles.
Farmaco (Società chimica italiana : 1989) 1998;53(2):161-8.
1998: Gabriella Vitale; Paola Corona; Mario Loriga; Giuseppe Paglietti
Quinoxaline chemistry. Part 10. Quinoxaline 10-oxa-analogues of trimetrexate (TMQ) and of 5,8-dideazafolic acid. Synthesis and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 1998;53(2):150-9.
1998: Mario Loriga; Gabriella Vitale; Giuseppe Paglietti
Quinoxaline chemistry. Part 9. Quinoxaline analogues of trimetrexate (TMQ) and 10-propargyl-5,8-dideazafolic acid (CB 3717) and its precursors. Synthesis and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 1998;53(2):139-49.
1997: Mario Loriga; P Moro; Paolo Sanna; Giuseppe Paglietti; Stefania Zanetti
Quinoxaline chemistry. Part 8. 2-[Anilino]-3-[carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity.
Farmaco (Società chimica italiana : 1989) 1997;52(8-9):531-7.
1997: Mario Loriga; Sandra Piras; Paolo Sanna; Giuseppe Paglietti
Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2-[aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity.
Farmaco (Società chimica italiana : 1989) 1997;52(3):157-66.
1996: S Piras; Mario Loriga; Giuseppe Paglietti; Maria Piera Demontis; Maria Vittoria Varoni; M C Fattaccio; Vittorio Anania
Quinoxaline chemistry. Part 6--Synthesis and evaluation of antiulcer and gastroprotective activity of 2-[arylmethylmercapto-, arylmethylsulfinyl-, piperazinyl-3-R-substituted]quinoxalines.
Farmaco (Società chimica italiana : 1989) 1996;51(8-9):569-77.
1996: Mario Loriga; M Fiore; Paolo Sanna; Giuseppe Paglietti
Quinoxaline chemistry. Part 5. 2-(R)-benzylaminoquinoxalines as nonclassical antifolate agents. Synthesis and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 1996;51(8-9):559-68.
1995: Mario Loriga; M Fiore; Paolo Sanna; Giuseppe Paglietti
Quinoxaline chemistry. Part 4. 2(R)-anilinoquinoxalines as nonclassical antifolate agents. Synthesis, structure elucidation and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 1995;50(5):289-301.
1995: Paolo Sanna; P A Sequi; Giuseppe Paglietti
Triazolo[4,5-f]quinolines. Part VI. Synthesis and evaluation of 9-aminoalkyl(aryl)-2-methyl-2H-[4,5-f]quinolines as anticancer agents. Preliminary results of in vitro screening.
Farmaco (Società chimica italiana : 1989) 1995;50(1):47-54.
1994: Giuseppe Paglietti; Paolo Sanna; Antonio Carta; Fabio Sparatore; I Vazzana; Alessandra T Peana; M Satta
Choleretic activity of 3-[ring substituted benzotriazol-1(2)-yl]alkanoic and alkenoic acids.
Farmaco (Società chimica italiana : 1989) 1994;40(11):693-702.
1994: Gérard A Pinna; M A Pirisi; Giuseppe Paglietti
Synthesis of 1-methyl-2,3-dimethyl-N(isopropyl)carbamates-4,5-dihydro-7-R'- 8-R-1H-benzo[g]indoles and evaluation of in vitro anticancer activity.
Farmaco (Società chimica italiana : 1989) 1994;49(2):121-6.
1993: S Piras; Mario Loriga; Giuseppe Paglietti; Fabio Sparatore; Maria Piera Demontis; Maria Vittoria Varoni; M C Fattaccio; Vittorio Anania
Synthesis and evaluation of gastroprotective activity of omeprazole related benzimidazole, imidazo[4,5-b]pyridine and quinoxaline 2-substituted derivatives.
Farmaco (Società chimica italiana : 1989) 1993;48(9):1249-59.
1992: Paolo Sanna; Antonio Carta; Giuseppe Paglietti; Stefania Zanetti; Giovanni Fadda
1,2,3-triazolo[4,5-h]quinolines. III. Preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract.
Farmaco (Società chimica italiana : 1989) 1992;47(7-8):1001-19.
1992: Mario Loriga; Giuseppe Paglietti; Fabio Sparatore; G Pinna; A Sisini
Synthesis of substituted DL-3(5-benzazolyl)alanines as dopa and alpha-methyldopa analogs and their effects on dopamine beta-hydroxylase, tyrosinase and diphenoloxidase.
Farmaco (Società chimica italiana : 1989) 1992;47(4):439-48.
1992: Mario Loriga; Giuseppe Paglietti; S Piras; Fabio Sparatore; Vittorio Anania; Maria Piera Demontis; Maria Vittoria Varoni; M C Fattaccio
Synthesis and evaluation of gastroprotective and antiulcer activity of some 2-substituted-1H-imidazo[4,5-b] pyridines and -1H-benzimidazoles.
Farmaco (Società chimica italiana : 1989) 1992;47(3):287-303.
1992: G Grella; Giuseppe Paglietti; Fabio Sparatore; M Satta; P Manca; Alessandra T Peana
Synthesis and choleretic activity of 3-[2-(3-R', 4-R'', 5-R'''-benzyl)-5-R-benzimidazol-1-yl]-butanoic acids.
Farmaco (Società chimica italiana : 1989) 1992;47(1):21-35.
1989: A Nuvole; Paolo Sanna; Giuseppe Paglietti; C Juliano; Stefania Zanetti; Piero Cappuccinelli
1,2,3-triazolo[4,5-f]quinolines. II. Preparation and antimicrobial evaluation of 6-ethyl-6,9-dihydro-1(2)(3)-R-1(2) (3)H-triazolo [4,5-f]quinolin-9-one-8-carboxylic acids as anti-infectives of the urinary tract (1).
Farmaco (Società chimica italiana : 1989) 1989;44(6):619-32.
1988: Giuseppe Paglietti; M A Pirisi; Mario Loriga; G E Grella; Fabio Sparatore; M Satta; P Manca
[Preparation and pharmacologic activity of 2-(4'R')benzyl-5R-benzimidazole and 2-(4'-pyridinyl)-5R-benzimidazoles. Analgesic activity and effect on conditioned avoidance response].
Il Farmaco; edizione scientifica 1988;43(3):215-26.
1988: Giuseppe Paglietti; M A Pirisi; Mario Loriga; G E Grella; Fabio Sparatore; M Satta; P Manca; Alessandra T Peana
[Preparation and pharmacologic activity of 2-(4'R')benzyl-5R-benzimidazole. Analgesic activity and effect on conditioned avoidance response].
Il Farmaco; edizione scientifica 1988;43(3):203-14.
1987: G Grella; Giuseppe Paglietti; Fabio Sparatore; P Manca; M Satta
[Synthesis and choleretic activity of 3-(2-aryl-5R-benzimidazol-1-yl) butanoic acids].
Il Farmaco; edizione scientifica 1987;42(7):475-90.