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Christopher Paige

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Alexandra Berger; Catherine Frelin; Norma P Gerard; Robert Herrington; Norman N Iscove; Divya K Shah; Juan Carlos Zúñiga-Pflücker; Patricia Benveniste; Christopher J Paige
Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.
A Berger; J Dida; N P Gerard; S Minkin; A H Tran; J Yeomans; Christopher J Paige
Diminished pheromone-induced sexual behavior in neurokinin-1 receptor deficient (TACR1(-/-)) mice.
Steven A Corfe; Christopher J Paige
The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation.

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2013: Alexandra Berger; Catherine Frelin; Norma P Gerard; Robert Herrington; Norman N Iscove; Divya K Shah; Juan Carlos Zúñiga-Pflücker; Patricia Benveniste; Christopher J Paige
Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.
PloS one 2013;8(3):e58787.
2012: A Berger; J Dida; N P Gerard; S Minkin; A H Tran; J Yeomans; Christopher J Paige
Diminished pheromone-induced sexual behavior in neurokinin-1 receptor deficient (TACR1(-/-)) mice.
Genes, brain, and behavior 2012;11(5):568-76.
2012: Steven A Corfe; Christopher J Paige
The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation.
Seminars in immunology 2012;24(3):198-208.
2012: Fiona M Guerra; Christopher J Paige; Steven A Corfe; Jennifer L Gommerman; Robert Rottapel
Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.
PloS one 2012;7(4):e35533.
2011: Steven A Corfe; Robert Rottapel; Christopher J Paige
Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3499-510.
2011: Nathalie Simard; Danijela konforte; Anne H Tran; Jessica Esufali; Warren J Leonard; Christopher J Paige
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(9):5244-53.
2011: Melissa Lewis; Maria Elena Meza-Avina; Lianhu Wei; Ian E Crandall; Angelica M Bello; Ewa Poduch; Yan Liu; Christopher J Paige; Kevin Kain; Emil F Pai; Lakshmi P Kotra
Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.
Journal of medicinal chemistry 2011;54(8):2891-901.
2010: Alexandra Berger; Patricia Benveniste; Steven A Corfe; Anne H Tran; Mary Barbara; Andrew Wakeham; Tak W Mak; Norman N Iscove; Christopher J Paige
Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development.
Blood 2010;116(19):3792-801.
2009: Alexandra Berger; Anne H Tran; Helen Dedier; Michael A Gardam; Christopher J Paige
Antimicrobial properties of hemokinin-1 against strains of Pseudomonas aeruginosa.
Life sciences 2009;85(19-20):700-3.
2009: Danijela Konforte; Christopher J Paige
Interleukin-21 regulates expression of the immediate-early lytic cycle genes and proteins in Epstein-Barr Virus infected B cells.
Virus research 2009;144(1-2):339-43.
2009: Alain Labbe; Megan Nelles; Jagdeep Walia; Lintao Jia; Caren Furlonger; Takahiro Nonaka; Jeffrey A Medin; Christopher J Paige
IL-12 immunotherapy of murine leukaemia: comparison of systemic versus gene modified cell therapy.
Journal of cellular and molecular medicine 2009;13(8B):1962-76.
2009: Angelica M Bello; Danijela Konforte; Ewa Poduch; Caren Furlonger; Lianhu Wei; Yan Liu; Melissa Lewis; Emil F Pai; Christopher J Paige; Lakshmi P Kotra
Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents.
Journal of medicinal chemistry 2009;52(6):1648-58.
2009: Danijela konforte; Nathalie Simard; Christopher J Paige
IL-21: an executor of B cell fate.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):1781-7.
2008: Danijela konforte; Nathalie Simard; Christopher J Paige
Interleukin-21 regulates expression of key Epstein-Barr virus oncoproteins, EBNA2 and LMP1, in infected human B cells.
Virology 2008;374(1):100-13.
2008: Craig D Milne; Steven A Corfe; Christopher J Paige
Heparan sulfate and heparin enhance ERK phosphorylation and mediate preBCR-dependent events during B lymphopoiesis.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(5):2839-47.
2007: Christopher J Paige
The future of health research is hanging in the balance.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2007;177(9):1057-8.
2007: Steven A Corfe; Alice P Gray; Christopher J Paige
Generation and characterization of stromal cell independent IL-7 dependent B cell lines.
Journal of immunological methods 2007;325(1-2):9-19.
2007: Alexandra Berger; Anne H Tran; Christopher J Paige
Co-regulated decrease of Neurokinin-1 receptor and Hemokinin-1 gene expression in monocytes and macrophages after activation with pro-inflammatory cytokines.
Journal of neuroimmunology 2007;187(1-2):83-93.
2007: Shaoping Deng; Daniel Moore; Xiaolun Huang; Moh-Moh Lian; Muhammad Mohiuddin; Ergun Velededeoglu; Major K Lee; Samsher Sonawane; James Kim; Jing Wang; Haiying Chen; Steven A Corfe; Christopher J Paige; Mark J Shlomchik; Andrew J Caton; James F Markmann
Cutting edge: transplant tolerance induced by anti-CD45RB requires B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6028-32.
2006: Danijela konforte; Christopher J Paige
Identification of cellular intermediates and molecular pathways induced by IL-21 in human B cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8381-92.
2006: Yu Zhang; Alexandra Berger; Craig D Milne; Christopher J Paige
Tachykinins in the immune system.
Current drug targets 2006;7(8):1011-20.
2006: Alain Labbe; Anne H Tran; Christopher J Paige
Murine model of immune-mediated rejection of the acute lymphoblastic leukemia 70Z/3.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(9):5354-61.
2006: Craig D Milne; Christopher J Paige
IL-7: a key regulator of B lymphopoiesis.
Seminars in immunology 2006;18(1):20-30.
2005: Craig D Milne; Y Zhang; Christopher J Paige
Stromal cells attract B-cell progenitors to promote B-cell-B-cell contact and maturation.
Scandinavian journal of immunology 2005;62 Suppl 1():67-72.
2005: Alexandra Berger; Christopher J Paige
Hemokinin-1 has Substance P-like function in U-251 MG astrocytoma cells: a pharmacological and functional study.
Journal of neuroimmunology 2005;164(1-2):48-56.
2004: Craig D Milne; Heather E Fleming; Christopher J Paige
IL-7 does not prevent pro-B/pre-B cell maturation to the immature/sIgM(+) stage.
European journal of immunology 2004;34(10):2647-55.
2004: Heather E Fleming; Craig D Milne; Christopher J Paige
CD45-deficient mice accumulate Pro-B cells both in vivo and in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2542-51.
2004: Craig D Milne; Heather E Fleming; Yu Zhang; Christopher J Paige
Mechanisms of selection mediated by interleukin-7, the preBCR, and hemokinin-1 during B-cell development.
Immunological reviews 2004;197():75-88.
2003: Minna Woo; Raza Hakem; Caren Furlonger; Anne Hakem; Gordon S Duncan; Takehiko Sasaki; Denis Bouchard; Liwei Lu; Gillian E Wu; Christopher J Paige; Tak W Mak
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.
Nature immunology 2003;4(10):1016-22.
2003: Yu Zhang; Christopher J Paige
T-cell developmental blockage by tachykinin antagonists and the role of hemokinin 1 in T lymphopoiesis.
Blood 2003;102(6):2165-72.
2002: Heather E Fleming; Christopher J Paige
Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection.
Seminars in immunology 2002;14(6):423-30.
2002: Laura Velazquez; Alec M Cheng; Heather E Fleming; Caren Furlonger; Shirly Vesely; alan bernstein; Christopher J Paige; Tony Pawson
Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice.
The Journal of experimental medicine 2002;195(12):1599-611.
2001: Heather E Fleming; Christopher J Paige
Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway.
Immunity 2001;15(4):521-31.
2001: A Stoddart; Heather E Fleming; Christopher J Paige
The role of homotypic interactions in the differentiation of B cell precursors.
European journal of immunology 2001;31(4):1160-72.
2000: Y Zhang; L Lu; Caren Furlonger; Gillian E Wu; Christopher J Paige
Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis.
Nature immunology 2000;1(5):392-7.
2000: A Stoddart; Heather E Fleming; Christopher J Paige
The role of the preBCR, the interleukin-7 receptor, and homotypic interactions during B-cell development.
Immunological reviews 2000;175():47-58.
1999: F Loder; B Mutschler; RJ Ray; Christopher J Paige; P Sideras; R Torres; Marinus C Lamers; Rita Carsetti
B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals.
The Journal of experimental medicine 1999;190(1):75-89.
1999: Mark A Lomaga; Wen-Chen Yeh; Ildiko Sarosi; Gordon S Duncan; Caren Furlonger; Alexandra Ho; Sean Morony; Charles Capparelli; Gwyneth Van; Stephen Kaufman; A van der Heiden; Annick Itie; Andrew Wakeham; W Khoo; Takehiko Sasaki; Z Cao; Josef M Penninger; Christopher J Paige; David L Lacey; Colin R Dunstan; william boyle; David V Goeddel; Tak W Mak
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Genes & development 1999;13(8):1015-24.
1999: LA Bentolila; S Olson; A Marshall; François Rougeon; Christopher J Paige; Noëlle Doyen; Gillian E Wu
Extensive junctional diversity in Ig light chain genes from early B cell progenitors of mu MT mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(4):2123-8.
1999: Hiroshi Nishina; C Vaz; P Billia; Mai Nghiem; Takehiko Sasaki; José Luis de la Pompa; K Furlonger; Christopher J Paige; C Hui; Klaus-Dieter Fischer; Hiroyuki Kishimoto; T Iwatsubo; T Katada; James R Woodgett; Josef M Penninger
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4.
Development (Cambridge, England) 1999;126(3):505-16.
1998: AJ Marshall; Noëlle Doyen; LA Bentolila; Christopher J Paige; Gillian E Wu
Terminal deoxynucleotidyl transferase expression during neonatal life alters D(H) reading frame usage and Ig-receptor-dependent selection of V regions.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6657-63.
1998: AJ Marshall; Heather E Fleming; Gillian E Wu; Christopher J Paige
Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(11):6038-45.
1998: RJ Ray; A Stoddart; J L Pennycook; H O Huner; Caren Furlonger; Gillian E Wu; Christopher J Paige
Stromal cell-independent maturation of IL-7-responsive pro-B cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(12):5886-97.
1997: A Stoddart; RJ Ray; Christopher J Paige
Analysis of murine CD22 during B cell development: CD22 is expressed on B cell progenitors prior to IgM.
International immunology 1997;9(10):1571-9.
1997: R Schmits; J Filmus; Nicole Gerwin; Giorgio Senaldi; F Kiefer; T Kundig; Andrew Wakeham; Arda Shahinian; C Catzavelos; J Rak; Caren Furlonger; A Zakarian; J J Simard; Pamela S Ohashi; Christopher J Paige; Jose-Carlos Gutierrez-Ramos; Tak W Mak
CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity.
Blood 1997;90(6):2217-33.
1997: G Pani; Katherine A Siminovitch; Christopher J Paige
The motheaten mutation rescues B cell signaling and development in CD45-deficient mice.
The Journal of experimental medicine 1997;186(4):581-8.
1997: James R Carlyle; Alison M Michie; Caren Furlonger; T Nakano; M J Lenardo; Christopher J Paige; Juan Carlos Zúñiga-Pflücker
Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes.
The Journal of experimental medicine 1997;186(2):173-82.
1997: AJ Marshall; Christopher J Paige; Gillian E Wu
V(H) repertoire maturation during B cell development in vitro: differential selection of Ig heavy chains by fetal and adult B cell progenitors.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(9):4282-91.
1996: A Stoddart; Y Zhang; Christopher J Paige
Molecular cloning of the cDNA encoding a murine sialic acid-specific 9-O-acetylesterase and RNA expression in cells of hematopoietic and non-hematopoietic origin.
Nucleic acids research 1996;24(20):4003-8.
1996: Barbara L Kee; Christopher J Paige
In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors.
Current biology : CB 1996;6(9):1159-69.
1996: R J Ray; Christopher J Paige; Caren Furlonger; S D Lyman; R Rottapel
Flt3 ligand supports the differentiation of early B cell progenitors in the presence of interleukin-11 and interleukin-7.
European journal of immunology 1996;26(7):1504-10.
1996: R J Ray; Caren Furlonger; D E Williams; Christopher J Paige
Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro.
European journal of immunology 1996;26(1):10-6.
1996: T Benatar; Rita Carsetti; Caren Furlonger; N Kamalia; Tak W Mak; Christopher J Paige
Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.
The Journal of experimental medicine 1996;183(1):329-34.
1995: Y Zhang; I McDermott; M Atkinson; Christopher J Paige
Identification of genes specifically expressed at discrete stages of B-cell development.
Annals of the New York Academy of Sciences 1995;764():25-6.
1995: A J Marshall; Barbara L Kee; Christopher J Paige; Gillian E Wu
Analysis of immunoglobulin gene rearrangement in fetal B-cell progenitors developing in vivo or in vitro.
Annals of the New York Academy of Sciences 1995;764():222-3.
1995: Barbara L Kee; Christopher J Paige
In-vitro models of B-lineage commitment.
Seminars in immunology 1995;7(3):143-54.
1995: Cynthia J Guidos; C J Williams; G E Wu; Christopher J Paige; Jayne S Danska
Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway.
The Journal of experimental medicine 1995;181(3):1187-95.
1995: Barbara L Kee; Christopher J Paige
Murine B cell development: commitment and progression from multipotential progenitors to mature B lymphocytes.
International review of cytology 1995;157():129-79.
1994: Amin Rahemtulla; TM Kündig; A Narendran; M F Bachmann; M Julius; Christopher J Paige; Pamela S Ohashi; Rolf M Zinkernagel; Tak W Mak
Class II major histocompatibility complex-restricted T cell function in CD4-deficient mice.
European journal of immunology 1994;24(9):2213-8.
1994: S A Berger; T W Mak; Christopher J Paige
Leukocyte common antigen (CD45) is required for immunoglobulin E-mediated degranulation of mast cells.
The Journal of experimental medicine 1994;180(2):471-6.
1994: Dale A Ramsden; Christopher J Paige; Gillian E Wu
Kappa light chain rearrangement in mouse fetal liver.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1150-60.
1994: T Tanaka; Gillian E Wu; Christopher J Paige
Characterization of the B cell-macrophage lineage transition in 70Z/3 cells.
European journal of immunology 1994;24(7):1544-8.
1994: Barbara L Kee; A Cumano; Norman N Iscove; Christopher J Paige
Stromal cell independent growth of bipotent B cell--macrophage precursors from murine fetal liver.
International immunology 1994;6(3):401-7.
1994: A Cumano; Barbara L Kee; Dale A Ramsden; A Marshall; Christopher J Paige; Gillian E Wu
Development of B lymphocytes from lymphoid committed and uncommitted progenitors.
Immunological reviews 1994;137():5-33.
1994: M J Atkinson; Y Chang; J W Celler; C Huang; Christopher J Paige; Gillian E Wu
Overusage of mouse DH gene segment, DFL16.1, is strain-dependent and determined by cis-acting elements.
Developmental immunology 1994;3(4):283-95.
1993: M J Atkinson; Christopher J Paige; Gillian E Wu
Map position and usage of 3' VH family members: usage is not position dependent.
International immunology 1993;5(12):1577-87.
1993: A Cumano; Caren Furlonger; Christopher J Paige
Differentiation and characterization of B-cell precursors detected in the yolk sac and embryo body of embryos beginning at the 10- to 12-somite stage.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6429-33.
1993: A Narendran; Dale A Ramsden; A Cumano; T Tanaka; Gillian E Wu; Christopher J Paige
B cell developmental defects in X-linked immunodeficiency.
International immunology 1993;5(2):139-44.
1992: Christopher J Paige; A Cumano; Dale A Ramsden; Gillian E Wu
The K:lambda ratio and B-cell development in the foetal liver.
Research in immunology 1992;143(8):822-4; discussion 830-9.
1992: Barbara L Kee; Christopher J Paige; Michelle Letarte
Characterization of murine CD10, an endopeptidase expressed on bone marrow adherent cells.
International immunology 1992;4(9):1041-7.
1992: T J Molina; Kenji Kishihara; David Siderovski; W van Ewijk; A Narendran; E Timms; Andrew Wakeham; Christopher J Paige; K U Hartmann; André Veillette
Profound block in thymocyte development in mice lacking p56lck.
Nature 1992;357(6374):161-4.
1992: Y Chang; Christopher J Paige; Gillian E Wu
Enumeration and characterization of DJH structures in mouse fetal liver.
The EMBO journal 1992;11(5):1891-9.
1992: A Cumano; Christopher J Paige; Norman N Iscove; G Brady
Bipotential precursors of B cells and macrophages in murine fetal liver.
Nature 1992;356(6370):612-5.
1992: A Narendran; A Cumano; K Dorshkind; Christopher J Paige
The stromal cell line S17 supports the growth of lipopolysaccharide-stimulated CBA/N spleen cell colonies in vitro.
European journal of immunology 1992;22(4):1001-6.
1992: A Cumano; Christopher J Paige
Enrichment and characterization of uncommitted B-cell precursors from fetal liver at day 12 of gestation.
The EMBO journal 1992;11(2):593-601.
1992: Christopher J Paige; A Cumano; G Brady; Norman N Iscove
Growth and differentiation of a bipotent precursor of B cells and macrophages.
Current topics in microbiology and immunology 1992;182():19-26.
1991: Christopher J Paige; A Cumano; Gillian E Wu
B cell commitment.
Seminars in immunology 1991;3(6):357-66.
1991: Amin Rahemtulla; Wai-Ping Fung-Leung; M W Schilham; TM Kündig; S R Sambhara; A Narendran; A Arabian; Andrew Wakeham; Christopher J Paige; Rolf M Zinkernagel
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.
Nature 1991;353(6340):180-4.
1991: D A Ferrick; A Cumano; Caren Furlonger; X Min; Norman N Iscove; Christopher J Paige; Tak W Mak
Expansion of myelopoietic precursors and inhibition of B-cell precursors in mice that express a T-cell receptor gamma (V gamma 1.1J gamma 4C gamma 4) transgene.
Journal of cellular physiology 1991;148(3):457-63.
1991: K McGinnes; V Quesniaux; J Hitzler; Christopher J Paige
Human B-lymphopoiesis is supported by bone marrow-derived stromal cells.
Experimental hematology 1991;19(4):294-303.
1991: K McGinnes; Christopher J Paige
Interleukins 1, 4 and 6 induce the colony formation of human bone marrow B lineage cells.
European journal of immunology 1991;21(5):1271-5.
1991: A F Eisen; M J Atkinson; J W Celler; Christopher J Paige; Gillian E Wu
Measurement of recombinase activity in a set of related Abelson murine leukemic virus pre-B cell lines: DJ/DJ lines have more recombinase activity than do VDJ/VDJ lines.
International immunology 1991;3(5):477-84.
1991: M J Atkinson; D A Michnick; Christopher J Paige; Gillian E Wu
Ig gene rearrangements on individual alleles of Abelson murine leukemia cell lines from (C57BL/6 x BALB/c) F1 fetal livers.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2805-12.
1991: K McGinnes; M Letarte; Christopher J Paige
B-lineage colonies from normal, human bone marrow are initiated by B cells and their progenitors.
Blood 1991;77(5):961-70.
1991: A Cumano; A Narendran; Christopher J Paige
Factors produced by stromal cells involved in B-cell development.
Advances in experimental medicine and biology 1991;303():191-7.
1990: A Cumano; K Dorshkind; S Gillis; Christopher J Paige
The influence of S17 stromal cells and interleukin 7 on B cell development.
European journal of immunology 1990;20(10):2183-9.
1990: K McGinnes; E Keystone; Earl R Bogoch; D Hastings; H A Messner; N Jamal; Christopher J Paige
Growth and detection of human bone marrow B-lineage colonies.
Blood 1990;76(5):896-905.
1990: Gillian E Wu; M J Atkinson; Dale A Ramsden; Christopher J Paige
VH gene repertoire.
Seminars in immunology 1990;2(3):207-16.
1990: H Hara; M Sam; R A Maki; G E Wu; Christopher J Paige
Characterization of a 70Z/3 pre-B cell derived macrophage clone. Differential expression of Hox family genes.
International immunology 1990;2(8):691-6.
1989: Christopher J Paige; G E Wu
The B cell repertoire.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1989;3(7):1818-24.
1989: Marinus C Lamers; M Vakil; J F Kearney; Jean Langhorne; Christopher J Paige; Michael Julius; Horst Mossmann; Rita Carsetti; Gabriele Köhler
Immune status of a mu, kappa transgenic mouse line. Deficient response to bacterially related antigens.
European journal of immunology 1989;19(3):459-68.
1988: P Benveniste; H Derry; G E Wu; Christopher J Paige; Richard G Miller
A sensitive dot blot procedure for detecting mRNA in lymphoid cells grown in liquid culture.
Journal of immunological methods 1988;107(2):165-77.