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Satheesh Palaninathan

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Satheesh K Palaninathan
Nearly 200 X-ray crystal structures of transthyretin: what do they tell us about this protein and the design of drugs for TTR amyloidoses?
Marcio V B Dias; William C Snee; Karen M Bromfield; Richard J Payne; Satheesh K Palaninathan; Alessio Ciulli; Nigel I Howard; Chris Abell; James C Sacchettini; Tom L Blundell
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.
Nishant D Shetty; Manchi C M Reddy; Satheesh K Palaninathan; Joshua L Owen; James C Sacchettini
Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein.

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All Publications

2012: Satheesh K Palaninathan
Nearly 200 X-ray crystal structures of transthyretin: what do they tell us about this protein and the design of drugs for TTR amyloidoses?
Current medicinal chemistry 2012;19(15):2324-42.
2011: Marcio V B Dias; William C Snee; Karen M Bromfield; Richard J Payne; Satheesh K Palaninathan; Alessio Ciulli; Nigel I Howard; Chris Abell; James C Sacchettini; Tom L Blundell
Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis.
The Biochemical journal 2011;436(3):729-39.
2010: Nishant D Shetty; Manchi C M Reddy; Satheesh K Palaninathan; Joshua L Owen; James C Sacchettini
Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein.
Protein science : a publication of the Protein Society 2010;19(8):1513-24.
2009: Manchi C M Reddy; Satheesh K Palaninathan; John B Bruning; Cory Thurman; Danielle Smith; James C Sacchettini
Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein.
The Journal of biological chemistry 2009;284(52):36581-91.
2009: Satheesh K Palaninathan; Nilofar N Mohamedmohaideen; Elisabetta Orlandini; Gabriella Ortore; Susanna Nencetti; Annalina Lapucci; Armando Rossello; Joel S Freundlich; James C Sacchettini
Novel transthyretin amyloid fibril formation inhibitors: synthesis, biological evaluation, and X-ray structural analysis.
PloS one 2009;4(7):e6290.
2008: Satheesh K Palaninathan; Nilofar N Mohamedmohaideen; William C Snee; Jeffery W Kelly; James C Sacchettini
Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.
Journal of molecular biology 2008;382(5):1157-67.
2008: Sreedhar Chinnaswamy; Ian Yarbrough; Satheesh K Palaninathan; C T Ranjith Kumar; Vinodhini Vijayaraghavan; Borries Demeler; Stanley M Lemon; James C Sacchettini; C Cheng Kao
A locking mechanism regulates RNA synthesis and host protein interaction by the hepatitis C virus polymerase.
The Journal of biological chemistry 2008;283(29):20535-46.
2008: Nilofar N Mohamedmohaideen; Satheesh K Palaninathan; Paul M Morin; Brad J Williams; Miriam Braunstein; Shane E Tichy; Joseph Locker; David H Russell; William R. Jacobs Jr.; James C Sacchettini
Structure and function of the virulence-associated high-temperature requirement A of Mycobacterium tuberculosis.
Biochemistry 2008;47(23):6092-102.
2007: Manchi C M Reddy; Satheesh K Palaninathan; Nishant D Shetty; Joshua L Owen; Misty D Watson; James C Sacchettini
High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme.
The Journal of biological chemistry 2007;282(37):27334-42.
2005: Steven M Johnson; H Michael Petrassi; Satheesh K Palaninathan; Nilofar N Mohamedmohaideen; Hans E Purkey; Christopher Nichols; Kyle P. Chiang; Traci Walkup; James C Sacchettini; K Barry Sharpless; Jeffery W Kelly
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
Journal of medicinal chemistry 2005;48(5):1576-87.
2004: Hans E Purkey; Satheesh K Palaninathan; Kathleen C Kent; Craig Smith; Stephen H Safe; James C Sacchettini; Jeffery W Kelly
Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.
Chemistry & biology 2004;11(12):1719-28.
2004: Sara L Adamski-Werner; Satheesh K Palaninathan; James C Sacchettini; Jeffery W Kelly
Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
Journal of medicinal chemistry 2004;47(2):355-74.
2003: Nora S Green; Satheesh K Palaninathan; James C Sacchettini; Jeffery W Kelly
Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.
Journal of the American Chemical Society 2003;125(44):13404-14.
2003: Hossein Razavi; Satheesh K Palaninathan; Evan T Powers; R Luke Wiseman; Hans E Purkey; Nilofar N Mohamedmohaideen; Songpon Deechongkit; Kyle P. Chiang; Maria T A Dendle; James C Sacchettini; Jeffery W Kelly
Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.
Angewandte Chemie (International ed. in English) 2003;42(24):2758-61.