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Colin Palmer

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Brian J Lipworth; Donald F Macgregor; Kaninika Basu; Helen P Donald; Simon A Ogston; Colin N A Palmer; Roger Tavendale; Somnath Mukhopadhyay
Tailored second-line therapy in asthmatic children with the Arg(16) genotype.
Samantha Alvarez-Madrazo; Morris Brown; Mark J Caulfield; Eleanor Davies; Anna F Dominiczak; Martin Farrall; Robert Fraser; Thomas Hedner; Mark Lathrop; Wai-Kwong Lee; Scott M MacKenzie; Olle Melander; Patricia B Munroe; Sandosh Padmanabhan; Colin N A Palmer; Nilesh Samani; Paul M Stewart; Björn Wahlstrand; John Webster; John M Connell
Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.
Jeffrey T-J Huang; Charles McSharry; Martina Messow; Douglas Miller; Somnath Mukhopadhyay; Colin N A Palmer; Petra Rauchhaus; Nicola Stevens; Osama Albarbarawi; Alun Barton; Jeffrey Brady; Rekha Chaudhuri; Giora Feuerstein; Christal Grierson; Christopher J Weir; Neil C Thomson
Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease.

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2013: Brian J Lipworth; Donald F Macgregor; Kaninika Basu; Helen P Donald; Simon A Ogston; Colin N A Palmer; Roger Tavendale; Somnath Mukhopadhyay
Tailored second-line therapy in asthmatic children with the Arg(16) genotype.
Clinical science (London, England : 1979) 2013;124(8):521-8.
2013: Samantha Alvarez-Madrazo; Morris Brown; Mark J Caulfield; Eleanor Davies; Anna F Dominiczak; Martin Farrall; Robert Fraser; Thomas Hedner; Mark Lathrop; Wai-Kwong Lee; Scott M MacKenzie; Olle Melander; Patricia B Munroe; Sandosh Padmanabhan; Colin N A Palmer; Nilesh Samani; Paul M Stewart; Björn Wahlstrand; John Webster; John M Connell
Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.
Hypertension 2013;61(1):232-9.
2012: Jeffrey T-J Huang; Charles McSharry; Martina Messow; Douglas Miller; Somnath Mukhopadhyay; Colin N A Palmer; Petra Rauchhaus; Nicola Stevens; Osama Albarbarawi; Alun Barton; Jeffrey Brady; Rekha Chaudhuri; Giora Feuerstein; Christal Grierson; Christopher J Weir; Neil C Thomson
Clinical validity of plasma and urinary desmosine as biomarkers for chronic obstructive pulmonary disease.
Thorax 2012;67(6):502-8.
2012: Liling L Warren; John C Whittaker; Peter M Woollard; Xin Yuan; Jennifer L Aponte; Lon R Cardon; Stephanie L Chissoe; Margaret G Ehm; Dana J Fraser; Timothy M Frayling; Matt D Hall; Li Li; Vincent Mooser; Andrew D Morris; Keith L Nangle; Matthew R Nelson; Colin N A Palmer; John R Perry; Judong Shen; Andrew J Slater; Simon D Topp; Dawn M Waterworth
Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation.
Diabetes 2012;61(5):1297-301.
2012: Colin N A Palmer; Ewan R Pearson; Markku Peltonen; Carlo Pirazzi; Lars Sjöström; Per-Arne Svensson; Martin Adiels; Jan Borén; Lindsay Burch; Maria Antonella Burza; Lena M S Carlsson; Helen Colhoun; John F Dillon; Alexander S Doney; Louise A Donnelly; Tim Frayling; Andrew T Hattersley; Peter Jacobson; Cristina Maglio; Mark McCarthy; Andrew D Morris; Stefano Romeo
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.
PloS one 2012;7(6):e39362.
2012: Larry G Higgins; Sitheswaran Nainamalai; Peter R Ashby; Wojciech G Garbacz; Mattias C U Gustafsson; C Roland Wolf; Colin N A Palmer
Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo.
PPAR research 2012;2012():216817.
2012: Harriet Corvol; J Stuart Elborn; Hartmut Grasemann; Judith Laki; Julie Beucher; Pierre-Yves Boëlle; Pierre-François Busson; Annick Clement; Céline Muselet-Charlier; Colin N A Palmer; Felix Ratjen; Anil Mehta
Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 2012;11(1):63-7.
2011: Jason Cunningham; Kaninika Basu; Roger Tavendale; Colin N A Palmer; Helen Smith; Somnath Mukhopadhyay
The CHI3L1 rs4950928 polymorphism is associated with asthma-related hospital admissions in children and young adults.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2011;106(5):381-6.
2011: Sara J Brown; Yuka Asai; Heather J Cordell; Linda E Campbell; Yiwei Zhao; Haihui Liao; Kate Northstone; John Henderson; Reza Alizadehfar; Moshe Ben-Shoshan; Kenneth Morgan; Graham Roberts; Laury J N Masthoff; Suzanne G M A Pasmans; Peter C van den Akker; Cisca Wijmenga; J O'B Hourihane; Colin N A Palmer; Gideon Lack; Ann Clarke; Peter R Hull; Alan D Irvine; W H Irwin McLean
Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.
The Journal of allergy and clinical immunology 2011;127(3):661-7.
2011: N Maneka G De Silva; Rachel M Freathy; Tom M Palmer; Louise A Donnelly; Jian'an Luan; Tom Gaunt; Claudia Langenberg; Michael N Weedon; Beverley Shields; Beatrice A Knight; Kirsten J Ward; Manjinder S Sandhu; Roger M Harbord; Mark I McCarthy; George Davey Smith; Shah Ebrahim; Andrew T Hattersley; Nicholas Wareham; Debbie A Lawlor; Andrew D Morris; Colin N A Palmer; Timothy M Frayling
Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance.
Diabetes 2011;60(3):1008-18.
2011: Ulla Sovio; Dennis O Mook-Kanamori; Nicole M Warrington; Robert Lawrence; Laurent Briollais; Colin N A Palmer; Joanne Cecil; Johanna K Sandling; Ann-Christine Syvänen; Marika Kaakinen; Lawrie J Beilin; Iona Y Millwood; Amanda J Bennett; Jaana Laitinen; Anneli Pouta; John Molitor; George Davey Smith; Yoav Ben-Shlomo; Vincent W V Jaddoe; Lyle J Palmer; Craig E Pennell; Tim J Cole; Mark I McCarthy; Marjo-Riitta Järvelin; Nicholas J Timpson
Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development.
PLoS genetics 2011;7(2):e1001307.
2010: Colin N A Palmer; Charlotte H Kimber; Alex S F Doney; Anna S Proia; Andrew D Morris; Eleonora Gaetani; Miriam Quarta; Roy Smith; Roberto Pola
Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.
Diabetes 2010;59(11):2945-8.
2010: Klaus Bønnelykke; Christian B Pipper; Roger Tavendale; Colin N A Palmer; Hans Bisgaard
Filaggrin gene variants and atopic diseases in early childhood assessed longitudinally from birth.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2010;21(6):954-61.
2010: Somnath Mukhopadhyay; Joseph Sypek; Roger Tavendale; Ulrike Gartner; John Winter; Wei Li; Karen Page; Margaret Fleming; Jeff Brady; Margot O'Toole; Donald F Macgregor; Samuel Goldman; Steve Tam; William W Abraham; Cara Williams; Douglas K Miller; Colin N A Palmer
Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.
The Journal of allergy and clinical immunology 2010;126(1):70-6.e16.
2010: Osama Albarbarawi; Alun Barton; Zhaosheng Lin; Eddie Takahashi; Ajay Buddharaju; Jeffrey Brady; Douglas Miller; Colin N A Palmer; Jeffrey T-J Huang
Measurement of urinary total desmosine and isodesmosine using isotope-dilution liquid chromatography-tandem mass spectrometry.
Analytical chemistry 2010;82(9):3745-50.
2010: Lindsay R Burch; Louise A Donnelly; Alex S F Doney; Jeffrey Brady; Anna M Tommasi; Adrian L Whitley; Catharine Goddard; Andrew D Morris; Michael K Hansen; Colin N A Palmer
Peroxisome proliferator-activated receptor-delta genotype influences metabolic phenotype and may influence lipid response to statin therapy in humans: a genetics of diabetes audit and research Tayside study.
The Journal of clinical endocrinology and metabolism 2010;95(4):1830-7.
2010: Malgorzata Romanowska; Louise Reilly; Colin N A Palmer; Mattias Gustafsson; John Foerster
Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo.
PloS one 2010;5(3):e9701.
2010: K Zhou; L Donnelly; L Burch; R Tavendale; Alex S F Doney; Graham P Leese; A T Hattersley; Mark I McCarthy; Andrew D Morris; Chim C Lang; Colin N A Palmer; E R Pearson
Loss-of-function CYP2C9 variants improve therapeutic response to sulfonylureas in type 2 diabetes: a Go-DARTS study.
Clinical pharmacology and therapeutics 2010;87(1):52-6.
2009: Kaninika Basu; Colin N A Palmer; Roger Tavendale; Brian J Lipworth; Somnath Mukhopadhyay
Adrenergic beta(2)-receptor genotype predisposes to exacerbations in steroid-treated asthmatic patients taking frequent albuterol or salmeterol.
The Journal of allergy and clinical immunology 2009;124(6):1188-94.e3.
2009: Colin N A Palmer
Novel insights into the etiology of diabetes from genome-wide association studies.
Diabetes 2009;58(11):2444-7.
2009: Lindsay R Burch; Kaixin Zhou; Louise A Donnelly; Alex S F Doney; Jeffrey Brady; Catharine Goddard; Andrew D Morris; Michael K Hansen; Colin N A Palmer
A single nucleotide polymorphism on exon-4 of the gene encoding PPARdelta is associated with reduced height in adults and children.
The Journal of clinical endocrinology and metabolism 2009;94(7):2587-93.
2009: Alex S F Doney; Jennifer Dannfald; Charlotte H Kimber; Louise A Donnelly; Ewan Pearson; Andrew D Morris; Colin N A Palmer
The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study.
Circulation. Cardiovascular genetics 2009;2(3):255-9.
2009: Kaixin Zhou; Louise A Donnelly; Charlotte H Kimber; Peter T Donnan; Alex S F Doney; Graham P Leese; Andrew T Hattersley; Mark I McCarthy; Andrew D Morris; Colin N A Palmer; Ewan R Pearson
Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study.
Diabetes 2009;58(6):1434-9.
2009: Toshifumi Nomura; Masashi Akiyama; Aileen Sandilands; Ikue Nemoto-Hasebe; Kaori Sakai; Akari Nagasaki; Colin N A Palmer; Frances J D Smith; W H Irwin McLean; Hiroshi Shimizu
Prevalent and rare mutations in the gene encoding filaggrin in Japanese patients with ichthyosis vulgaris and atopic dermatitis.
The Journal of investigative dermatology 2009;129(5):1302-5.
2009: Ann Sergeant; Linda E Campbell; Peter R Hull; Martin Porter; Colin N A Palmer; Frances J D Smith; W H Irwin McLean; Colin S Munro
Heterozygous null alleles in filaggrin contribute to clinical dry skin in young adults and the elderly.
The Journal of investigative dermatology 2009;129(4):1042-5.
2009: A Liedén; E Ekelund; I-C Kuo; Ingrid Kockum; C-H Huang; Lotus Mallbris; S P Lee; L K Seng; G Y Chin; Carl-Fredrik Wahlgren; Colin N A Palmer; Bengt Björkstén; Mona Ståhle; M Nordenskjöld; M Nordensköld; M Bradley; K Y Chua; Mauro D'Amato
Cornulin, a marker of late epidermal differentiation, is down-regulated in eczema.
Allergy 2009;64(2):304-11.
2009: Nicholas J Timpson; Cecilia M Lindgren; Michael Weedon; Joshua Randall; Willem H Ouwehand; David P Strachan; N William Rayner; Mark Walker; Graham A Hitman; Alex S F Doney; Colin N A Palmer; Andrew D Morris; Andrew T Hattersley; Eleftheria Zeggini; Timothy M Frayling; Mark I McCarthy
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
Diabetes 2009;58(2):505-10.
2009: Hans Bisgaard; Klaus Bønnelykke; Patrick M A Sleiman; Martin Brasholt; Bo Chawes; Eskil Kreiner-Møller; Malene Stage; Cecilia Kim; Roger Tavendale; Florent Baty; Christian Bressen Pipper; Colin N A Palmer; Hakon Hakonarsson
Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.
American journal of respiratory and critical care medicine 2009;179(3):179-85.
2009: Mattias Gustafsson; Deborah Knight; Colin N A Palmer
Ligand modulated antagonism of PPARgamma by genomic and non-genomic actions of PPARdelta.
PloS one 2009;4(9):e7046.
2009: Santiago Rodriguez; Amanda J Hall; Raquel Granell; W H Irwin McLean; Alan D Irvine; Colin N A Palmer; George Davey Smith; J Henderson; Ian N M Day
Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort.
PloS one 2009;4(6):e5784.
2008: Hana Lango; Colin N A Palmer; Andrew D Morris; Eleftheria Zeggini; Andrew T Hattersley; Mark I McCarthy; Timothy M Frayling; Michael Weedon
Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
Diabetes 2008;57(11):3129-35.
2008: Stephan Weidinger; Hansjörg Baurecht; Stefan Wagenpfeil; John Henderson; Natalija Novak; Aileen Sandilands; Huijia Chen; Elke Rodriguez; Grainne M O'Regan; Rosemarie Watson; Haihui Liao; Yiwei Zhao; Jonathan N W N Barker; Michael Allen; Nick Reynolds; Simon Meggitt; Kate Northstone; George D Smith; Carolin Strobl; Caroline Stahl; Thomas Kneib; Norman Klopp; Thomas Bieber; Heidrun Behrendt; Colin N A Palmer; H-Erich Wichmann; Johannes Ring; Thomas Illig; W H Irwin McLean; Alan D Irvine
Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk.
The Journal of allergy and clinical immunology 2008;122(3):560-8.e4.
2008: Kaninika Basu; Colin N A Palmer; Brian J Lipworth; W H Irwin McLean; Ana Terron-Kwiatkowski; Yiwei Zhao; Haihui Liao; Frances J D Smith; A Mitra; Somnath Mukhopadhyay
Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults.
Allergy 2008;63(9):1211-7.
2008: Hans Bisgaard; Angela Simpson; Colin N A Palmer; Klaus Bønnelykke; Irwin McLean; Somnath Mukhopadhyay; Christian B Pipper; Liselotte B Halkjaer; Brian Lipworth; Jenny Hankinson; Ashley Woodcock; Adnan Custovic
Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure.
PLoS medicine 2008;5(6):e131.
2008: Toshifumi Nomura; Masashi Akiyama; Aileen Sandilands; Ikue Nemoto-Hasebe; Kaori Sakai; Akari Nagasaki; Mitsuhito Ota; Hiroo Hata; Alan T Evans; Colin N A Palmer; Hiroshi Shimizu; W H Irwin McLean
Specific filaggrin mutations cause ichthyosis vulgaris and are significantly associated with atopic dermatitis in Japan.
The Journal of investigative dermatology 2008;128(6):1436-41.
2008: W H Irwin McLean; Colin N A Palmer; John Henderson; Michael Kabesch; Stephan Weidinger; Alan D Irvine
Filaggrin variants confer susceptibility to asthma.
The Journal of allergy and clinical immunology 2008;121(5):1294-5; author reply 1295-6.
2008: Michael Weedon; Nicholas J Timpson; Debbie A Lawlor; Anneli Pouta; Yoav Ben-Shlomo; Aimo Ruokonen; Shah Ebrahim; Beverley Shields; Eleftheria Zeggini; Michael N Weedon; Cecilia M Lindgren; Hana Lango; David Melzer; Luigi Ferrucci; Giuseppe Paolisso; Matthew J Neville; Fredrik Karpe; Colin N A Palmer; Andrew D Morris; Paul Elliott; Marjo-Riitta Jarvelin; George Davey Smith; Mark I McCarthy; Andrew T Hattersley; Timothy M Frayling
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
Diabetes 2008;57(5):1419-26.
2008: Roger Tavendale; Donald F Macgregor; Somnath Mukhopadhyay; Colin N A Palmer
A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications.
The Journal of allergy and clinical immunology 2008;121(4):860-3.
2008: Louise A Donnelly; Colin N A Palmer; Adrian L Whitley; Chim Choy Lang; Alex S F Doney; Andrew D Morris; Peter T Donnan
Apolipoprotein E genotypes are associated with lipid-lowering responses to statin treatment in diabetes: a Go-DARTS study.
Pharmacogenetics and genomics 2008;18(4):279-87.
2008: J Henderson; Kate Northstone; Simon P Lee; Haihui Liao; Yiwei Zhao; Marcus E Pembrey; Somnath Mukhopadhyay; George Davey Smith; Colin N A Palmer; W H Irwin McLean; Alan D Irvine
The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.
The Journal of allergy and clinical immunology 2008;121(4):872-7.e9.
2008: Elisabeth Ekelund; Agne Liedén; Jenny Link; Simon P Lee; Mauro D'Amato; Colin N A Palmer; Ingrid Kockum; Maria Bradley
Loss-of-function variants of the filaggrin gene are associated with atopic eczema and associated phenotypes in Swedish families.
Acta dermato-venereologica 2008;88(1):15-9.
2007: Manjinder S Sandhu; Michael Weedon; Katherine A Fawcett; Jon Wasson; Sally L Debenham; Allan Daly; Hana Lango; Timothy M Frayling; Rosalind J Neumann; Richard Sherva; Ilana Blech; Paul D P Pharoah; Colin N A Palmer; Charlotte Kimber; Roger Tavendale; Andrew D Morris; Mark I McCarthy; Mark Walker; Graham A Hitman; Benjamin Glaser; M Alan Permutt; Andrew T Hattersley; Nicholas J Wareham; Inês Barroso
Common variants in WFS1 confer risk of type 2 diabetes.
Nature genetics 2007;39(8):951-3.
2007: Ewan R Pearson; Louise A Donnelly; Charlotte Kimber; Adrian Whitley; Alex S F Doney; Mark I McCarthy; Andrew T Hattersley; Andrew D Morris; Colin N A Palmer
Variation in TCF7L2 influences therapeutic response to sulfonylureas: a GoDARTs study.
Diabetes 2007;56(8):2178-82.
2007: Yiwei Zhao; Ana Terron-Kwiatkowski; Haihui Liao; Simon P Lee; Michael H Allen; Peter R Hull; Linda E Campbell; Richard C Trembath; Francesca Capon; Christopher E M Griffiths; David Burden; Ross McManus; Rosalind Hughes; Brian Kirby; Sarah F Rogers; Oliver Fitzgerald; David Kane; J N W N Barker; Colin N A Palmer; Alan D Irvine; W H Irwin McLean
Filaggrin null alleles are not associated with psoriasis.
The Journal of investigative dermatology 2007;127(8):1878-82.
2007: Joanne E Cecil; Colin N A Palmer; Bettina Fischer; Peter Watt; Deborah J Wallis; Inez Murrie; Marion M Hetherington
Variants of the peroxisome proliferator-activated receptor gamma- and beta-adrenergic receptor genes are associated with measures of compensatory eating behaviors in young children.
The American journal of clinical nutrition 2007;86(1):167-73.
2007: Colin N A Palmer; Tahmina Ismail; Simon P Lee; Ana Terron-Kwiatkowski; Yiwei Zhao; Haihui Liao; Frances J D Smith; W H Irwin McLean; Somnath Mukhopadhyay
Filaggrin null mutations are associated with increased asthma severity in children and young adults.
The Journal of allergy and clinical immunology 2007;120(1):64-8.
2007: CH Kimber; Alex S F Doney; Ewan R Pearson; Mark I McCarthy; Andrew T Hattersley; Graham P Leese; Andrew D Morris; Colin N A Palmer
TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.
Diabetologia 2007;50(6):1186-91.
2007: Aileen Sandilands; Ana Terron-Kwiatkowski; Peter R Hull; Gráinne M O'Regan; Timothy H Clayton; Rosemarie M Watson; Thomas Carrick; Alan T Evans; Haihui Liao; Yiwei Zhao; Linda E Campbell; Matthias Schmuth; Robert Gruber; Andreas R Janecke; Peter M Elias; Maurice A M van Steensel; Ivo Nagtzaam; Michel van Geel; Peter M Steijlen; Colin S Munro; Daniel G Bradley; Colin N A Palmer; Frances J D Smith; W H Irwin McLean; Alan D Irvine
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema.
Nature genetics 2007;39(5):650-4.
2007: Colin N A Palmer; Alex S F Doney; Tahmina Ismail; Simon P Lee; Inez Murrie; Donald F Macgregor; Somnath Mukhopadhyay
PPARG locus haplotype variation and exacerbations in asthma.
Clinical pharmacology and therapeutics 2007;81(5):713-8.
2007: J N W N Barker; Colin N A Palmer; Yiwei Zhao; Haihui Liao; Peter R Hull; Simon P Lee; Michael H Allen; Simon J Meggitt; Nick J Reynolds; Richard C Trembath; W H Irwin McLean
Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood.
The Journal of investigative dermatology 2007;127(3):564-7.
2007: Toshifumi Nomura; Aileen Sandilands; Masashi Akiyama; Haihui Liao; Alan T Evans; Kaori Sakai; Mitsuhito Ota; Hisashi Sugiura; Kazuo Yamamoto; Hiroshi Sato; Colin N A Palmer; Frances J D Smith; W H Irwin McLean; Hiroshi Shimizu
Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis.
The Journal of allergy and clinical immunology 2007;119(2):434-40.
2006: Liliane Michalik; Johan Auwerx; Joel P Berger; V Krishna Chatterjee; Christopher K Glass; Frank J Gonzalez; Paul A Grimaldi; Takashi Kadowaki; Mitchell Lazar; Stephen O'Rahilly; Colin N A Palmer; Jorge Plutzky; Janardan K Reddy; Bruce M Spiegelman; Bart Staels; Walter Wahli
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Pharmacological reviews 2006;58(4):726-41.
2006: Colin N A Palmer; Brian J Lipworth; S Lee; Tahmina Ismail; Donald F Macgregor; Somnath Mukhopadhyay
Arginine-16 beta2 adrenoceptor genotype predisposes to exacerbations in young asthmatics taking regular salmeterol.
Thorax 2006;61(11):940-4.
2006: Colin N A Palmer; Alex S F Doney; Simon P Lee; Inez Murrie; Tahmina Ismail; Donald F Macgregor; Somnath Mukhopadhyay
Glutathione S-transferase M1 and P1 genotype, passive smoking, and peak expiratory flow in asthma.
Pediatrics 2006;118(2):710-6.
2006: Stephan Weidinger; Thomas Illig; Hansjörg Baurecht; Alan D Irvine; Elke Rodriguez; Amalia Diaz-Lacava; Norman Klopp; Stefan Wagenpfeil; Yiwei Zhao; Haihui Liao; Simon P Lee; Colin N A Palmer; Claudia Jenneck; Laura Maintz; Tobias Hagemann; Heidrun Behrendt; Johannes Ring; Markus M Nothen; W H Irwin McLean; Natalija Novak
Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations.
The Journal of allergy and clinical immunology 2006;118(1):214-9.
2006: Joanne E Cecil; Peter Watt; Colin N A Palmer; Marion M Hetherington
Energy balance and food intake: the role of PPARgamma gene polymorphisms.
Physiology & behavior 2006;88(3):227-33.
2006: Colin N A Palmer; Alan D Irvine; Ana Terron-Kwiatkowski; Yiwei Zhao; Haihui Liao; Simon P Lee; David R Goudie; Aileen Sandilands; Linda E Campbell; Frances J D Smith; Gráinne M O'Regan; Rosemarie M Watson; Joanne E Cecil; Sherri J Bale; John G Compton; John J DiGiovanna; Philip Fleckman; Sue Lewis-Jones; Gehan Arseculeratne; Ann Sergeant; Colin S Munro; Brahim El Houate; Ken McElreavey; Liselotte B Halkjaer; Hans Bisgaard; Somnath Mukhopadhyay; W H Irwin McLean
Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis.
Nature genetics 2006;38(4):441-6.
2006: Blair H Smith; Harry Campbell; Douglas Blackwood; John Connell; Mike Connor; Ian J Deary; Anna F Dominiczak; Bridie Fitzpatrick; Ian Ford; Cathy Jackson; Gillian Haddow; Shona Kerr; Robert Lindsay; Mark McGilchrist; Robin Morton; Graeme Murray; Colin N A Palmer; Jill P Pell; Stuart H Ralston; David St Clair; frank sullivan; Graham Watt; Roland Wolf; Alan Wright; David Porteous; Andrew D Morris
Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability.
BMC medical genetics 2006;7():74.
2005: Morag C Jarvis; Tim J B Gray; Colin N A Palmer
Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line.
Oncogene 2005;24(55):8211-5.
2005: Alex S F Doney; Bettina Fischer; Simon P Lee; Andrew D Morris; Graham P Leese; Colin N A Palmer
Association of common variation in the PPARA gene with incident myocardial infarction in individuals with type 2 diabetes: a Go-DARTS study.
Nuclear receptor 2005;3():4.
2005: Joanne E Cecil; Peter Watt; Inez Murrie; Wendy L Wrieden; Deborah J Wallis; Marion M Hetherington; Caroline Bolton-Smith; Colin N A Palmer
Childhood obesity and socioeconomic status: a novel role for height growth limitation.
International journal of obesity (2005) 2005;29(10):1199-203.
2005: Dagmar Kastner-Cole; Colin N A Palmer; Simon A Ogston; Anil Mehta; Somnath Mukhopadhyay
Overweight and obesity in deltaF508 homozygous cystic fibrosis.
The Journal of pediatrics 2005;147(3):402-4.
2005: Joanne E Cecil; Colin N A Palmer; Wendy L Wrieden; Inez Murrie; Caroline Bolton-Smith; Peter Watt; Deborah J Wallis; Marion M Hetherington
Energy intakes of children after preloads: adjustment, not compensation.
The American journal of clinical nutrition 2005;82(2):302-8.
2005: Joanne E Cecil; Bettina Fischer; Alex S F Doney; Marion M Hetherington; Peter Watt; Wendy L Wrieden; Caroline Bolton-Smith; Colin N A Palmer
The Pro12Ala and C-681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren.
Diabetologia 2005;48(8):1496-502.
2005: Tracey L Graham; Claudette Mookherjee; Keith Suckling; Colin N A Palmer; Lisa Patel
The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice.
Atherosclerosis 2005;181(1):29-37.
2005: Alex S F Doney; Simon Lee; Graham P Leese; Andrew D Morris; Colin N A Palmer
Increased cardiovascular morbidity and mortality in type 2 diabetes is associated with the glutathione S transferase theta-null genotype: a Go-DARTS study.
Circulation 2005;111(22):2927-34.
2005: Paul Targett-Adams; Marion J McElwee; Ewa Ehrenborg; Mattias Gustafsson; Colin N A Palmer; John McLauchlan
A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein.
Biochimica et biophysica acta 2005;1728(1-2):95-104.
2004: Alex S F Doney; Bettina Fischer; Graham P Leese; Andrew D Morris; Colin N A Palmer
Cardiovascular risk in type 2 diabetes is associated with variation at the PPARG locus: a Go-DARTS study.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2403-7.
2004: Ruth L Stephen; Mattias Gustafsson; Morag Jarvis; Roger Tatoud; Barry R Marshall; Deborah Knight; Ewa Ehrenborg; Adrian L Harris; C Roland Wolf; Colin N A Palmer
Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.
Cancer research 2004;64(9):3162-70.
2004: Alex S F Doney; Bettina Fischer; Joanne E Cecil; K Boylan; F E McGuigan; S H Ralston; Andrew D Morris; Colin N A Palmer
Association of the Pro12Ala and C1431T variants of PPARG and their haplotypes with susceptibility to Type 2 diabetes.
Diabetologia 2004;47(3):555-8.
2003: Alex S F Doney; Bettina Fischer; Joanne E Cecil; Patricia T W Cohen; Douglas I Boyle; Graham P Leese; Andrew D Morris; Colin N A Palmer
Male preponderance in early diagnosed type 2 diabetes is associated with the ARE insertion/deletion polymorphism in the PPP1R3A locus.
BMC genetics 2003;4():11.
2003: Colin N A Palmer; Vanessa Young; Meilien Ho; Alex S F Doney; Jill J F Belch
Association of common variation in glutathione S-transferase genes with premature development of cardiovascular disease in patients with systemic sclerosis.
Arthritis and rheumatism 2003;48(3):854-5.
2002: Alex S F Doney; Bettina Fischer; David Frew; Alastair Cumming; David M Flavell; Michael J World; Hugh E Montgomery; Douglas Boyle; Andrew Morris; Colin N A Palmer
Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight.
BMC genetics 2002;3():21.
2002: V Young; M Ho; Helen Vosper; Jill J F Belch; Colin N A Palmer
Elevated expression of the genes encoding TNF-alpha and thromboxane synthase in leucocytes from patients with systemic sclerosis.
Rheumatology (Oxford, England) 2002;41(8):869-75.
2002: Helen Vosper; Guennadi A Khoudoli; Tracey L Graham; Colin N A Palmer
Peroxisome proliferator-activated receptor agonists, hyperlipidaemia, and atherosclerosis.
Pharmacology & therapeutics 2002;95(1):47-62.
2002: Douglas J A Adamson; Colin N A Palmer
Fluorescence-based ligand-binding assays for peroxisome proliferator-activated receptors.
Methods in enzymology 2002;357():188-97.
2002: Douglas J A Adamson; David Frew; Roger Tatoud; C Roland Wolf; Colin N A Palmer
Diclofenac antagonizes peroxisome proliferator-activated receptor-gamma signaling.
Molecular pharmacology 2002;61(1):7-12.
2001: Mattias Gustafsson; Colin N A Palmer; C R Wolf; Claes von Wachenfeldt
Fatty-acid-displaced transcriptional repressor, a conserved regulator of cytochrome P450 102 transcription in Bacillus species.
Archives of microbiology 2001;176(6):459-64.
2001: Helen Vosper; Lisa Patel; Tracey L Graham; Guennadi A Khoudoli; A Hill; Colin H Macphee; I Pinto; Stephen A Smith; Keith Suckling; C Roland Wolf; Colin N A Palmer
The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages.
The Journal of biological chemistry 2001;276(47):44258-65.
1999: Mirsada Causevic; C Roland Wolf; Colin N A Palmer
Substitution of a conserved amino acid residue alters the ligand binding properties of peroxisome proliferator activated receptors.
FEBS letters 1999;463(3):205-10.
1999: Colin N A Palmer; Mattias Gustafsson; H Dobson; Claes von Wachenfeldt; C Roland Wolf
Adaptive responses to fatty acids are mediated by the regulated expression of cytochromes P450.
Biochemical Society transactions 1999;27(4):374-8.
1998: Colin N A Palmer; C Roland Wolf
cis-parinaric acid is a ligand for the human peroxisome proliferator activated receptor gamma: development of a novel spectrophotometric assay for the discovery of PPARgamma ligands.
FEBS letters 1998;431(3):476-80.
1998: Colin N A Palmer; E Axen; V Hughes; C Roland Wolf
The repressor protein, Bm3R1, mediates an adaptive response to toxic fatty acids in Bacillus megaterium.
The Journal of biological chemistry 1998;273(29):18109-16.
1998: Colin N A Palmer
Quantification of cytochrome P450 gene expression by RNase protection analysis.
Methods in molecular biology (Clifton, N.J.) 1998;107():267-77.
1997: Colin N A Palmer; Mirsada Causevic; C Roland Wolf
Modulation of fatty acid signalling by cytochrome P-450-mediated hydroxylation.
Biochemical Society transactions 1997;25(4):1160-5.
1997: N English; Colin N A Palmer; William L Alworth; L Kang; V Hughes; C Roland Wolf
Fatty acid signals in Bacillus megaterium are attenuated by cytochrome P-450-mediated hydroxylation.
The Biochemical journal 1997;327 ( Pt 2)():363-8.