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Bernhard Palsson

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Computational Biology

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Computer Simulation

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Bacterial Genome

Physiology

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Co-Publications
Name
13
Edwards, Jeremy
11
Papin, Jason
11
Schilling, Christophe
10
Famili, Iman
10
Price, Nathan
8
Reed, Jennifer
7
Keasling, Jay
7
Emerson, Stephen
7
Clarke, Michael
6
Francis, Karl
6
Koller, Manfred
6
Vo, Thuy
5
Covert, Markus
4
Knight, Eric
4
Fong, Stephen

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Publications

TOP 3
Lewis Nathan E; Cho Byung-Kwan; Knight Eric M; Palsson Bernhard O
Gene expression profiling and the use of genome-scale in silico models of Escherichia coli for analysis: providing context for content.
Sigurdsson Martin I; Jamshidi Neema; Jonsson Jon J; Palsson Bernhard O
Genome-scale network analysis of imprinted human metabolic genes.
Jamshidi Neema; Palsson Bernhard O
Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes.

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All Publications

2009: Lewis Nathan E; Cho Byung-Kwan; Knight Eric M; Palsson Bernhard O
Gene expression profiling and the use of genome-scale in silico models of Escherichia coli for analysis: providing context for content.
Journal of bacteriology 2009;191(11):3437-44.
2009: Sigurdsson Martin I; Jamshidi Neema; Jonsson Jon J; Palsson Bernhard O
Genome-scale network analysis of imprinted human metabolic genes.
Epigenetics : official journal of the DNA Methylation Society 2009;4(1):43-6.
2009: Jamshidi Neema; Palsson Bernhard O
Using in silico models to simulate dual perturbation experiments: procedure development and interpretation of outcomes.
BMC systems biology 2009;3():44.
2009: Mo Monica L; Palsson Bernhard O; Herrgård Markus J
Connecting extracellular metabolomic measurements to intracellular flux states in yeast.
BMC systems biology 2009;3():37.
2008: Becker Scott A; Palsson Bernhard O
Context-specific metabolic networks are consistent with experiments.
PLoS computational biology 2008;4(5):e1000082.
2008: Becker Scott A; Palsson Bernhard O
Three factors underlying incorrect in silico predictions of essential metabolic genes.
BMC systems biology 2008;2():14.
2007: Oh You-Kwan; Palsson Bernhard O; Park Sung M; Schilling Christophe H; Mahadevan Radhakrishnan
Genome-scale reconstruction of metabolic network in Bacillus subtilis based on high-throughput phenotyping and gene essentiality data.
The Journal of biological chemistry 2007;282(39):28791-9.
2007: Cho Byung-Kwan; Charusanti Pep; Herrgård Markus J; Palsson Bernhard O
Microbial regulatory and metabolic networks.
Current opinion in biotechnology 2007;18(4):360-4.
2007: Anderson Megan J; DeLabarre Byron; Raghunathan Anu; Palsson Bernhard O; Brunger Axel T; Quake Stephen R
Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices.
Biochemistry 2007;46(19):5722-31.
2007: Vo Thuy D; Paul Lee W N; Palsson Bernhard O
Systems analysis of energy metabolism elucidates the affected respiratory chain complex in Leigh's syndrome.
Molecular genetics and metabolism 2007;91(1):15-22.
2007: Vo Thuy D; Palsson Bernhard O
Building the power house: recent advances in mitochondrial studies through proteomics and systems biology.
American journal of physiology. Cell physiology 2007;292(1):C164-77.
2007: Jamshidi Neema; Vo Thuy D; Palsson Bernhard O
In silico analysis of SNPs and other high-throughput data.
Methods in molecular biology (Clifton, N.J.) 2007;366():267-85.
2007: Joyce Andrew R; Palsson Bernhard O
Toward whole cell modeling and simulation: comprehensive functional genomics through the constraint-based approach.
Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques 2007;64():265, 267-309.
2006: Vo Thuy D; Palsson Bernhard O
Isotopomer analysis of myocardial substrate metabolism: a systems biology approach.
Biotechnology and bioengineering 2006;95(5):972-83.
2006: Reed Jennifer L; Patel Trina R; Chen Keri H; Joyce Andrew R; Applebee Margaret K; Herring Christopher D; Bui Olivia T; Knight Eric M; Fong Stephen S; Palsson Bernhard O
Systems approach to refining genome annotation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17480-4.
2006: Gianchandani Erwin P; Papin Jason A; Price Nathan D; Joyce Andrew R; Palsson Bernhard O
Matrix formalism to describe functional states of transcriptional regulatory systems.
PLoS computational biology 2006;2(8):e101.
2006: Barrett Christian L; Palsson Bernhard O
Iterative reconstruction of transcriptional regulatory networks: an algorithmic approach.
PLoS computational biology 2006;2(5):e52.
2006: Fong Stephen S; Nanchen Annik; Palsson Bernhard O; Sauer Uwe
Latent pathway activation and increased pathway capacity enable Escherichia coli adaptation to loss of key metabolic enzymes.
The Journal of biological chemistry 2006;281(12):8024-33.
2006: Mahadevan R; Bond D R; Butler J E; Esteve-Nuñez A; Coppi M V; Palsson B O; Schilling C H; Lovley D R
Characterization of metabolism in the Fe(III)-reducing organism Geobacter sulfurreducens by constraint-based modeling.
Applied and environmental microbiology 2006;72(2):1558-68.
2006: Reed Jennifer L; Famili Iman; Thiele Ines; Palsson Bernhard O
Towards multidimensional genome annotation.
Nature reviews. Genetics 2006;7(2):130-41.
2006: Barrett Christian L; Price Nathan D; Palsson Bernhard O
Network-level analysis of metabolic regulation in the human red blood cell using random sampling and singular value decomposition.
BMC bioinformatics 2006;7():132.
2005: Barrett Christian L; Herring Christopher D; Reed Jennifer L; Palsson Bernhard O
The global transcriptional regulatory network for metabolism in Escherichia coli exhibits few dominant functional states.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(52):19103-8.
2005: Fong Stephen S; Burgard Anthony P; Herring Christopher D; Knight Eric M; Blattner Frederick R; Maranas Costas D; Palsson Bernhard O
In silico design and adaptive evolution of Escherichia coli for production of lactic acid.
Biotechnology and bioengineering 2005;91(5):643-8.
2005: Famili Iman; Mahadevan Radhakrishnan; Palsson Bernhard O
k-Cone analysis: determining all candidate values for kinetic parameters on a network scale.
Biophysical journal 2005;88(3):1616-25.
2005: Papin Jason A; Hunter Tony; Palsson Bernhard O; Subramaniam Shankar
Reconstruction of cellular signalling networks and analysis of their properties.
Nature reviews. Molecular cell biology 2005;6(2):99-111.
2005: Mahadevan R; Palsson B O
Properties of metabolic networks: structure versus function.
Biophysical journal 2005;88(1):L07-9.
2004: Papin Jason A; Reed Jennifer L; Palsson Bernhard O
Hierarchical thinking in network biology: the unbiased modularization of biochemical networks.
Trends in biochemical sciences 2004;29(12):641-7.
2004: Price Nathan D; Schellenberger Jan; Palsson Bernhard O
Uniform sampling of steady-state flux spaces: means to design experiments and to interpret enzymopathies.
Biophysical journal 2004;87(4):2172-86.
2004: Vo Thuy D; Greenberg Harvey J; Palsson Bernhard O
Reconstruction and functional characterization of the human mitochondrial metabolic network based on proteomic and biochemical data.
The Journal of biological chemistry 2004;279(38):39532-40.
2004: Papin Jason A; Stelling Joerg; Price Nathan D; Klamt Steffen; Schuster Stefan; Palsson Bernhard O
Comparison of network-based pathway analysis methods.
Trends in biotechnology 2004;22(8):400-5.
2004: Papin Jason A; Palsson Bernhard O
The JAK-STAT signaling network in the human B-cell: an extreme signaling pathway analysis.
Biophysical journal 2004;87(1):37-46.
2004: Covert Markus W; Knight Eric M; Reed Jennifer L; Herrgard Markus J; Palsson Bernhard O
Integrating high-throughput and computational data elucidates bacterial networks.
Nature 2004;429(6987):92-6.
2004: Papin Jason A; Palsson Bernhard O
Topological analysis of mass-balanced signaling networks: a framework to obtain network properties including crosstalk.
Journal of theoretical biology 2004;227(2):283-97.
2004: Raghunathan Anu; Price Nathan D; Galperin Michael Y; Makarova Kira S; Purvine Samuel; Picone Alex F; Cherny Tim; Xie Tao; Reilly Thomas J; Munson Robert; Tyler Ryan E; Akerley Brian J; Smith Arnold L; Palsson Bernhard O; Kolker Eugene
In Silico Metabolic Model and Protein Expression of Haemophilus influenzae Strain Rd KW20 in Rich Medium.
Omics : a journal of integrative biology 2004;8(1):25-41.
2003: Covert Markus W; Famili Iman; Palsson Bernhard O
Identifying constraints that govern cell behavior: a key to converting conceptual to computational models in biology?
Biotechnology and bioengineering 2003;84(7):763-72.
2003: Famili Iman; Forster Jochen; Nielsen Jens; Palsson Bernhard O
Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13134-9.
2003: Price Nathan D; Reed Jennifer L; Papin Jason A; Wiback Sharon J; Palsson Bernhard O
Network-based analysis of metabolic regulation in the human red blood cell.
Journal of theoretical biology 2003;225(2):185-94.
2003: Famili Iman; Palsson Bernhard O
Systemic metabolic reactions are obtained by singular value decomposition of genome-scale stoichiometric matrices.
Journal of theoretical biology 2003;224(1):87-96.
2003: Kolker Eugene; Purvine Samuel; Galperin Michael Y; Stolyar Serg; Goodlett David R; Nesvizhskii Alexey I; Keller Andrew; Xie Tao; Eng Jimmy K; Yi Eugene; Hood Leroy; Picone Alex F; Cherny Tim; Tjaden Brian C; Siegel Andrew F; Reilly Thomas J; Makarova Kira S; Palsson Bernhard O; Smith Arnold L
Initial proteome analysis of model microorganism Haemophilus influenzae strain Rd KW20.
Journal of bacteriology 2003;185(15):4593-602.
2003: Famili Iman; Palsson Bernhard O
The convex basis of the left null space of the stoichiometric matrix leads to the definition of metabolically meaningful pools.
Biophysical journal 2003;85(1):16-26.
2003: Papin Jason A; Price Nathan D; Wiback Sharon J; Fell David A; Palsson Bernhard O
Metabolic pathways in the post-genome era.
Trends in biochemical sciences 2003;28(5):250-8.
2003: Palsson Bernhard O; Price Nathan D; Papin Jason A
Development of network-based pathway definitions: the need to analyze real metabolic networks.
Trends in biotechnology 2003;21(5):195-8.
2003: Price Nathan D; Papin Jason A; Schilling Christophe H; Palsson Bernhard O
Genome-scale microbial in silico models: the constraints-based approach.
Trends in biotechnology 2003;21(4):162-9.
2003: Covert Markus W; Palsson Bernhard O
Constraints-based models: regulation of gene expression reduces the steady-state solution space.
Journal of theoretical biology 2003;221(3):309-25.
2003: Raghunathan Anuradha; Palsson Bernhard O
Scalable method to determine mutations that occur during adaptive evolution of Escherichia coli.
Biotechnology letters 2003;25(5):435-41.
2003: Price Nathan D; Reed Jennifer L; Papin Jason A; Famili Iman; Palsson Bernhard O
Analysis of metabolic capabilities using singular value decomposition of extreme pathway matrices.
Biophysical journal 2003;84(2 Pt 1):794-804.
2003: Ibarra R U; Fu P; Palsson B O; DiTonno J R; Edwards J S
Quantitative analysis of Escherichia coli metabolic phenotypes within the context of phenotypic phase planes.
Journal of molecular microbiology and biotechnology 2003;6(2):101-8.
2003: Förster Jochen; Famili Iman; Palsson Bernhard O; Nielsen Jens
Large-scale evaluation of in silico gene deletions in Saccharomyces cerevisiae.
Omics : a journal of integrative biology 2003;7(2):193-202.
2003: Reed Jennifer L; Vo Thuy D; Schilling Christophe H; Palsson Bernhard O
An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR).
Genome biology 2003;4(9):R54.
2002: Ibarra Rafael U; Edwards Jeremy S; Palsson Bernhard O
Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth.
Nature 2002;420(6912):186-9.
2002: Schilling Christophe H; Covert Markus W; Famili Iman; Church George M; Edwards Jeremy S; Palsson Bernhard O
Genome-scale metabolic model of Helicobacter pylori 26695.
Journal of bacteriology 2002;184(16):4582-93.
2002: Wiback Sharon J; Palsson Bernhard O
Extreme pathway analysis of human red blood cell metabolism.
Biophysical journal 2002;83(2):808-18.
2002: Kauffman Kenneth J; Pajerowski John David; Jamshidi Neema; Palsson Bernhard O; Edwards Jeremy S
Description and analysis of metabolic connectivity and dynamics in the human red blood cell.
Biophysical journal 2002;83(2):646-62.
2002: Lee Gyun Min; Fong Stephen S; Oh Duk Jae; Francis Karl; Palsson Bernhard O
Characterization and efficacy of PKH26 as a probe to study the replication history of the human hematopoietic KG1a progenitor cell line.
In vitro cellular & developmental biology. Animal 2002;38(2):90-6.
2002: Edwards Jeremy S; Ramakrishna Ramprasad; Palsson Bernhard O
Characterizing the metabolic phenotype: a phenotype phase plane analysis.
Biotechnology and bioengineering 2002;77(1):27-36.
2002: Kolker Eugene; Purvine Samuel; Picone Alex; Cherny Tim; Akerley Brian J; Munson Robert S; Palsson Bernhard O; Daines Dayle A; Smith Arnold L
H. influenzae Consortium: integrative study of H. influenzae-human interactions.
Omics : a journal of integrative biology 2002;6(4):341-8.
2001: Jamshidi N; Edwards J S; Fahland T; Church G M; Palsson B O
Dynamic simulation of the human red blood cell metabolic network.
Bioinformatics (Oxford, England) 2001;17(3):286-7.
2001: Covert M W; Schilling C H; Famili I; Edwards J S; Goryanin I I; Selkov E; Palsson B O
Metabolic modeling of microbial strains in silico.
Trends in biochemical sciences 2001;26(3):179-86.
2001: Ramakrishna R; Edwards J S; McCulloch A; Palsson B O
Flux-balance analysis of mitochondrial energy metabolism: consequences of systemic stoichiometric constraints.
American journal of physiology. Regulatory, integrative and comparative physiology 2001;280(3):R695-704.
2001: Edwards J S; Ibarra R U; Palsson B O
In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data.
Nature biotechnology 2001;19(2):125-30.
2000: Edwards J S; Palsson B O
Robustness analysis of the Escherichia coli metabolic network.
Biotechnology progress 2000;16(6):927-39.
2000: Oh D J; Martinez A R; Lee G M; Francis K; Palsson B O
Intercellular adhesion can be visualized using fluorescently labeled fibrosarcoma HT1080 cells cocultured with hematopoietic cell lines or CD34(+) enriched human mobilized peripheral blood cells.
Cytometry 2000;40(2):119-25.
2000: Oh D J; Martinez A R; Lee G M; Francis K; Palsson B O
Extension of osmolality-induced podia is observed from fluorescently labeled hematopoietic cell lines in hyperosmotic medium.
Cytometry 2000;40(2):109-18.
2000: Edwards J S; Palsson B O
The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5528-33.
2000: Schilling C H; Palsson B O
Assessment of the metabolic capabilities of Haemophilus influenzae Rd through a genome-scale pathway analysis.
Journal of theoretical biology 2000;203(3):249-83.
2000: Schilling C H; Letscher D; Palsson B O
Theory for the systemic definition of metabolic pathways and their use in interpreting metabolic function from a pathway-oriented perspective.
Journal of theoretical biology 2000;203(3):229-48.
2000: Edwards J S; Palsson B O
Metabolic flux balance analysis and the in silico analysis of Escherichia coli K-12 gene deletions.
BMC bioinformatics 2000;1():1.
1999: Holloway W; Martinez A R; Oh D J; Francis K; Ramakrishna R; Palsson B O
Key adhesion molecules are present on long podia extended by hematopoietic cells.
Cytometry 1999;37(3):171-7.
1999: Oh D J; Lee G M; Francis K; Palsson B O
Phototoxicity of the fluorescent membrane dyes PKH2 and PKH26 on the human hematopoietic KG1a progenitor cell line.
Cytometry 1999;36(4):312-8.
1999: Edwards J S; Palsson B O
Systems properties of the Haemophilus influenzae Rd metabolic genotype.
The Journal of biological chemistry 1999;274(25):17410-6.
1999: Schilling C H; Schuster S; Palsson B O; Heinrich R
Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era.
Biotechnology progress 1999;15(3):296-303.
1999: Schilling C H; Edwards J S; Palsson B O
Toward metabolic phenomics: analysis of genomic data using flux balances.
Biotechnology progress 1999;15(3):288-95.
1998: Francis K; Ramakrishna R; Holloway W; Palsson B O
Two new pseudopod morphologies displayed by the human hematopoietic KG1a progenitor cell line and by primary human CD34(+) cells.
Blood 1998;92(10):3616-23.
1998: Mandalam R K; Palsson B O
Elemental balancing of biomass and medium composition enhances growth capacity in high-density Chlorella vulgaris cultures.
Biotechnology and bioengineering 1998;59(5):605-11.
1998: Andreadis S; Fuller A O; Palsson B O
Cell cycle dependence of retroviral transduction: An issue of overlapping time scales.
Biotechnology and bioengineering 1998;58(2-3):272-81.
1998: Edwards J S; Palsson B O
How will bioinformatics influence metabolic engineering?
Biotechnology and bioengineering 1998;58(2-3):162-9.
1998: Schilling C H; Palsson B O
The underlying pathway structure of biochemical reaction networks.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(8):4193-8.
1997: Francis K; Palsson B O
Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12258-62.
1997: Andreadis S T; Brott D; Fuller A O; Palsson B O
Moloney murine leukemia virus-derived retroviral vectors decay intracellularly with a half-life in the range of 5.5 to 7.5 hours.
Journal of virology 1997;71(10):7541-8.
1997: Andreadis S; Palsson B O
Coupled effects of polybrene and calf serum on the efficiency of retroviral transduction and the stability of retroviral vectors.
Human gene therapy 1997;8(3):285-91.
1997: Palsson B O
What lies beyond bioinformatics?
Nature biotechnology 1997;15(1):3-4.
1996: Koller M R; Oxender M; Brott D A; Palsson B O
flt-3 ligand is more potent than c-kit ligand for the synergistic stimulation of ex vivo hematopoietic cell expansion.
Journal of hematotherapy 1996;5(5):449-59.
1996: Andreadis S T; Palsson B O
Kinetics of retrovirus mediated gene transfer: the importance of intracellular half-life of retroviruses.
Journal of theoretical biology 1996;182(1):1-20.
1996: Chuck A S; Clarke M F; Palsson B O
Retroviral infection is limited by Brownian motion.
Human gene therapy 1996;7(13):1527-34.
1996: Chuck A S; Palsson B O
Consistent and high rates of gene transfer can be obtained using flow-through transduction over a wide range of retroviral titers.
Human gene therapy 1996;7(6):743-50.
1996: Rogers C E; Bradley M S; Palsson B O; Koller M R
Flow cytometric analysis of human bone marrow perfusion cultures: erythroid development and relationship with burst-forming units-erythroid.
Experimental hematology 1996;24(5):597-604.
1995: Koller M R; Bradley M S; Palsson B O
Growth factor consumption and production in perfusion cultures of human bone marrow correlate with specific cell production.
Experimental hematology 1995;23(12):1275-83.
1995: Eipers P G; Krauss J C; Palsson B O; Emerson S G; Todd R F; Clarke M F
Retroviral-mediated gene transfer in human bone marrow cells growth in continuous perfusion culture vessels.
Blood 1995;86(10):3754-62.
1995: Koller M R; Palsson M A; Manchel I; Palsson B O
Long-term culture-initiating cell expansion is dependent on frequent medium exchange combined with stromal and other accessory cell effects.
Blood 1995;86(5):1784-93.
1995: Koller M R; Manchel I; Newsom B S; Palsson M A; Palsson B O
Bioreactor expansion of human bone marrow: comparison of unprocessed, density-separated, and CD34-enriched cells.
Journal of hematotherapy 1995;4(3):159-69.
1993: Koller M R; Emerson S G; Palsson B O
Large-scale expansion of human stem and progenitor cells from bone marrow mononuclear cells in continuous perfusion cultures.
Blood 1993;82(2):378-84.
1993: Palsson B O; Lee I D
Model complexity has a significant effect on the numerical value and interpretation of metabolic sensitivity coefficients.
Journal of theoretical biology 1993;161(3):299-315.
1993: Palsson B O; Paek S H; Schwartz R M; Palsson M; Lee G M; Silver S; Emerson S G
Expansion of human bone marrow progenitor cells in a high cell density continuous perfusion system.
Bio/technology (Nature Publishing Company) 1993;11(3):368-72.
1992: Lee I D; Palsson B O
A Macintosh software package for simulation of human red blood cell metabolism.
Computer methods and programs in biomedicine 1992;38(4):195-226.
1992: Keasling J D; Palsson B O; Cooper S
Replication of prophage P1 is cell-cycle specific.
Journal of bacteriology 1992;174(13):4457-62.
1992: Keasling J D; Palsson B O; Cooper S
Replication of mini-F plasmids during the bacterial division cycle.
Research in microbiology 1992;143(6):541-8.
1992: Savinell J M; Palsson B O
Optimal selection of metabolic fluxes for in vivo measurement. II. Application to Escherichia coli and hybridoma cell metabolism.
Journal of theoretical biology 1992;155(2):215-42.
1992: Savinell J M; Palsson B O
Optimal selection of metabolic fluxes for in vivo measurement. I. Development of mathematical methods.
Journal of theoretical biology 1992;155(2):201-14.
1992: Keasling J D; Palsson B O; Cooper S
Replication of the R6K plasmid during the Escherichia coli cell cycle.
Journal of bacteriology 1992;174(3):1060-2.
1992: Savinell J M; Palsson B O
Network analysis of intermediary metabolism using linear optimization. II. Interpretation of hybridoma cell metabolism.
Journal of theoretical biology 1992;154(4):455-73.
1992: Savinell J M; Palsson B O
Network analysis of intermediary metabolism using linear optimization. I. Development of mathematical formalism.
Journal of theoretical biology 1992;154(4):421-54.
1992: Varma A; el-Awar F Y; Palsson B O; Emerson S G; Clarke M F
Can Dexter cultures support stem cell proliferation?
Experimental hematology 1992;20(1):87-91.
1992: Schwartz R M; Caldwell J; Clarke M F; Emerson S G; Palsson B O
The influence of extra-cellular matrix and stroma remodeling on the productivity of long-term human bone marrow cultures.
Cytotechnology 1992;10(3):217-24.
1991: Schwartz R M; Emerson S G; Clarke M F; Palsson B O
In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors.
Blood 1991;78(12):3155-61.
1991: Ozturk S S; Palsson B O
Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 2. Effects of serum concentration, dissolved oxygen concentration, and medium pH in a batch reactor.
Biotechnology progress 1991;7(6):481-94.
1991: Ozturk S S; Palsson B O
Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 1. Analysis of data from controlled batch reactors.
Biotechnology progress 1991;7(6):471-80.
1991: Schwartz R M; Palsson B O; Emerson S G
Rapid medium perfusion rate significantly increases the productivity and longevity of human bone marrow cultures.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(15):6760-4.
1991: Caldwell J; Palsson B O; Locey B; Emerson S G
Culture perfusion schedules influence the metabolic activity and granulocyte-macrophage colony-stimulating factor production rates of human bone marrow stromal cells.
Journal of cellular physiology 1991;147(2):344-53.
1991: Keasling J D; Palsson B O; Cooper S
Cell-cycle-specific F plasmid replication: regulation by cell size control of initiation.
Journal of bacteriology 1991;173(8):2673-80.
1991: Ozturk S S; Palsson B O
Examination of serum and bovine serum albumin as shear protective agents in agitated cultures of hybridoma cells.
Journal of biotechnology 1991;18(1-2):13-28.
1991: Emerson S G; Palsson B O; Clarke M F
The construction of high efficiency human bone marrow tissue ex vivo.
Journal of cellular biochemistry 1991;45(3):268-72.
1991: Lee G M; Varma A; Palsson B O
Application of population balance model to the loss of hybridoma antibody productivity.
Biotechnology progress 1991;7(1):72-5.
1991: Caldwell J; Locey B; Clarke M F; Emerson S G; Palsson B O
Influence of medium exchange schedules on metabolic, growth, and GM-CSF secretion rates of genetically engineered NIH-3T3 cells.
Biotechnology progress 1991;7(1):1-8.
1990: Ozturk S S; Palsson B O
Effect of initial cell density on hybridoma growth, metabolism, and monoclonal antibody production.
Journal of biotechnology 1990;16(3-4):259-78.
1990: Ozturk S S; Palsson B O
Effects of dissolved oxygen on hybridoma cell growth, metabolism, and antibody production kinetics in continuous culture.
Biotechnology progress 1990;6(6):437-46.
1990: Ozturk S S; Dressman J B; Palsson B O
On the use of the quasi-equilibrium assumption for drug dissolution.
Pharmaceutical research 1990;7(4):425-9.
1990: Ozturk S S; Palsson B O
Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum-free media.
Hybridoma 1990;9(2):167-75.
1990: Ozturk S S; Palsson B O
Chemical decomposition of glutamine in cell culture media: effect of media type, pH, and serum concentration.
Biotechnology progress 1990;6(2):121-8.
1990: Palsson B O; Keasling J D; Emerson S G
The regulatory mechanisms of human immunodeficiency virus replication predict multiple expression rates.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(2):772-6.
1990: Joshi A; Palsson B O
Metabolic dynamics in the human red cell. Part IV--Data prediction and some model computations.
Journal of theoretical biology 1990;142(1):69-85.
1990: Joshi A; Palsson B O
Metabolic dynamics in the human red cell. Part III--Metabolic reaction rates.
Journal of theoretical biology 1990;142(1):41-68.
1990: Lee I D; Palsson B O
A comprehensive model of human erythrocyte metabolism: extensions to include pH effects.
Biomedica biochimica acta 1990;49(8-9):771-89.
1989: Lee G M; Savinell J M; Palsson B O
Serum can act as a shear protecting agent in agitated hybridoma cell cultures.
Hybridoma 1989;8(6):639-45.
1989: Joshi A; Palsson B O
Metabolic dynamics in the human red cell. Part II--Interactions with the environment.
Journal of theoretical biology 1989;141(4):529-45.
1989: Joshi A; Palsson B O
Metabolic dynamics in the human red cell. Part I--A comprehensive kinetic model.
Journal of theoretical biology 1989;141(4):515-28.
1989: Keasling J D; Palsson B O
ColE1 plasmid replication: a simple kinetic description from a structured model.
Journal of theoretical biology 1989;141(4):447-61.
1989: Lee G M; Huard T K; Palsson B O
Effect of serum concentration on hybridoma cell growth and monoclonal antibody production at various initial cell densities.
Hybridoma 1989;8(3):369-75.
1989: Keasling J D; Palsson B O
On the kinetics of plasmid replication.
Journal of theoretical biology 1989;136(4):487-92.
1988: Ozturk S S; Palsson B O; Donohoe B; Dressman J B
Kinetics of release from enteric-coated tablets.
Pharmaceutical research 1988;5(9):550-65.
1988: Ozturk S S; Palsson B O; Dressman J B
Dissolution of ionizable drugs in buffered and unbuffered solutions.
Pharmaceutical research 1988;5(5):272-82.
1988: Palsson B O; Groshans T M
Mathematical modelling of dynamics and control in metabolic networks: VI. Dynamic bifurcations in single biochemical control loops.
Journal of theoretical biology 1988;131(1):43-53.

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