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Timothy Palzkill

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.8 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Brown Nicholas G; Shanker Sreejesh; Prasad B V Venkataram; Palzkill Timothy
Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis.
Marciano David C; Brown Nicholas G; Palzkill Timothy
Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase.
Bush Karen; Jacoby George A; Amicosante Gianfranco; Bonomo Robert A; Bradford Patricia; Cornaglia Giuseppe; Garau Javier; Giamarellou Helen; Jarlier Vincent; Martinez-Martinez Luis; Miriagou Vivi; Palzkill Timothy; Pascual Alvaro; Rodriguez-Baño Jesus; Rossolini Gian Maria; Sougakoff Wladimir; Vatopoulos Alkiviadis
Comment on: Redefining extended-spectrum beta-lactamases: balancing science and clinical need.

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All Publications

2009: Brown Nicholas G; Shanker Sreejesh; Prasad B V Venkataram; Palzkill Timothy
Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis.
The Journal of biological chemistry 2009;284(48):33703-12.
2009: Marciano David C; Brown Nicholas G; Palzkill Timothy
Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase.
Protein science : a publication of the Protein Society 2009;18(10):2080-9.
2009: Bush Karen; Jacoby George A; Amicosante Gianfranco; Bonomo Robert A; Bradford Patricia; Cornaglia Giuseppe; Garau Javier; Giamarellou Helen; Jarlier Vincent; Martinez-Martinez Luis; Miriagou Vivi; Palzkill Timothy; Pascual Alvaro; Rodriguez-Baño Jesus; Rossolini Gian Maria; Sougakoff Wladimir; Vatopoulos Alkiviadis
Comment on: Redefining extended-spectrum beta-lactamases: balancing science and clinical need.
The Journal of antimicrobial chemotherapy 2009;64(1):212-3; author reply 213-5.
2009: Yuan Ji; Huang Wanzhi; Chow Dar-Chone; Palzkill Timothy
Fine mapping of the sequence requirements for binding of beta-lactamase inhibitory protein (BLIP) to TEM-1 beta-lactamase using a genetic screen for BLIP function.
Journal of molecular biology 2009;389(2):401-12.
2009: Wang Jihong; Palzkill Timothy; Chow Dar-Chone
Structural insight into the kinetics and DeltaCp of interactions between TEM-1 beta-lactamase and beta-lactamase inhibitory protein (BLIP).
The Journal of biological chemistry 2009;284(1):595-609.
2008: Marciano David C; Pennington Jeanine M; Wang Xiaohu; Wang Jian; Chen Yu; Thomas Veena L; Shoichet Brian K; Palzkill Timothy
Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase.
Journal of molecular biology 2008;384(1):151-64.
2008: Wang Xiaohu; Gao Haichun; Shen Yufeng; Weinstock George M; Zhou Jizhong; Palzkill Timothy
A high-throughput percentage-of-binding strategy to measure binding energies in DNA-protein interactions: application to genome-scale site discovery.
Nucleic acids research 2008;36(15):4863-71.
2008: Brinkman Mary Beth; McGill Melanie A; Pettersson Jonas; Rogers Arthur; Matejková Petra; Smajs David; Weinstock George M; Norris Steven J; Palzkill Timothy
A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin.
Infection and immunity 2008;76(5):1848-57.
2008: Hyser Joseph M; Zeng Carl Q-Y; Beharry Zanna; Palzkill Timothy; Estes Mary K
Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4.
Virology 2008;373(1):211-28.
2008: Gao Haichun; Pattison Donna; Yan Tingfen; Klingeman Dawn M; Wang Xiaohu; Petrosino Joseph; Hemphill Lisa; Wan Xiufeng; Leaphart Adam B; Weinstock George M; Palzkill Timothy; Zhou Jizhong
Generation and validation of a Shewanella oneidensis MR-1 clone set for protein expression and phage display.
PloS one 2008;3(8):e2983.
2008: Titz Björn; Rajagopala Seesandra V; Goll Johannes; Häuser Roman; McKevitt Matthew T; Palzkill Timothy; Uetz Peter
The binary protein interactome of Treponema pallidum--the syphilis spirochete.
PloS one 2008;3(5):e2292.
2008: Matejková Petra; Strouhal Michal; Smajs David; Norris Steven J; Palzkill Timothy; Petrosino Joseph F; Sodergren Erica; Norton Jason E; Singh Jaz; Richmond Todd A; Molla Michael N; Albert Thomas J; Weinstock George M
Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays.
BMC microbiology 2008;8():76.
2008: Gao Haichun; Wang Xiaohu; Yang Zamin K; Palzkill Timothy; Zhou Jizhong
Probing regulon of ArcA in Shewanella oneidensis MR-1 by integrated genomic analyses.
BMC genomics 2008;9():42.
2007: Marciano David C; Karkouti Omid Y; Palzkill Timothy
A fitness cost associated with the antibiotic resistance enzyme SME-1 beta-lactamase.
Genetics 2007;176(4):2381-92.
2007: Wang Jihong; Zhang Zhen; Palzkill Timothy; Chow Dar-Chone
Thermodynamic investigation of the role of contact residues of beta-lactamase-inhibitory protein for binding to TEM-1 beta-lactamase.
The Journal of biological chemistry 2007;282(24):17676-84.
2007: Holloway Alisha K; Palzkill Timothy; Bull James J
Experimental evolution of gene duplicates in a bacterial plasmid model.
Journal of molecular evolution 2007;64(2):215-22.
2007: Rajagopala Seesandra V; Titz Björn; Goll Johannes; Parrish Jodi R; Wohlbold Katrin; McKevitt Matthew T; Palzkill Timothy; Mori Hirotada; Finley Russell L; Uetz Peter
The protein network of bacterial motility.
Molecular systems biology 2007;3():128.
2006: Cushman Ian; Palzkill Timothy; Moore Mary Shannon
Using peptide arrays to define nuclear carrier binding sites on nucleoporins.
Methods (San Diego, Calif.) 2006;39(4):329-41.
2006: Brinkman Mary Beth; McKevitt Matthew; McLoughlin Melanie; Perez Carla; Howell Jerrilyn; Weinstock George M; Norris Steven J; Palzkill Timothy
Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome.
Journal of clinical microbiology 2006;44(3):888-91.
2005: Majiduddin Fahd K; Palzkill Timothy
Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1.
Antimicrobial agents and chemotherapy 2005;49(8):3421-7.
2005: McKevitt Matthew; Brinkman Mary Beth; McLoughlin Melanie; Perez Carla; Howell Jerrilyn K; Weinstock George M; Norris Steven J; Palzkill Timothy
Genome scale identification of Treponema pallidum antigens.
Infection and immunity 2005;73(7):4445-50.
2005: Adediran S A; Zhang Zhen; Nukaga Michiyoshi; Palzkill Timothy; Pratt R F
The D-methyl group in beta-lactamase evolution: evidence from the Y221G and GC1 mutants of the class C beta-lactamase of Enterobacter cloacae P99.
Biochemistry 2005;44(20):7543-52.
2005: Beharry Zanna; Palzkill Timothy
Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa.
The Journal of biological chemistry 2005;280(18):17786-91.
2005: Smajs David; McKevitt Matthew; Howell Jerrilyn K; Norris Steven J; Cai Wei-Wen; Palzkill Timothy; Weinstock George M
Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection.
Journal of bacteriology 2005;187(5):1866-74.
2004: Materon Isabel C; Beharry Zanna; Huang Wanzhi; Perez Carla; Palzkill Timothy
Analysis of the context dependent sequence requirements of active site residues in the metallo-beta-lactamase IMP-1.
Journal of molecular biology 2004;344(3):653-63.
2004: Zhang Zhen; Palzkill Timothy
Dissecting the protein-protein interface between beta-lactamase inhibitory protein and class A beta-lactamases.
The Journal of biological chemistry 2004;279(41):42860-6.
2004: Mustafi Devkumar; Hofer Jennifer E; Huang Wanzhi; Palzkill Timothy; Makinen Marvin W
Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2004;60(6):1279-89.
2004: Buynak John D; Chen Hansong; Vogeti Lakshminaryana; Gadhachanda Venkat Rao; Buchanan Christine A; Palzkill Timothy; Shaw Robert W; Spencer James; Walsh Timothy R
Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases.
Bioorganic & medicinal chemistry letters 2004;14(5):1299-304.
2004: Beharry Zanna; Chen Hansong; Gadhachanda Venkat R; Buynak John D; Palzkill Timothy
Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis.
Biochemical and biophysical research communications 2004;313(3):541-5.
2003: Huang Wanzhi; Beharry Zanna; Zhang Zhen; Palzkill Timothy
A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays.
Protein engineering 2003;16(11):853-60.
2003: Zhang Zhen; Palzkill Timothy
Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein.
The Journal of biological chemistry 2003;278(46):45706-12.
2003: McKevitt Matthew; Patel Krupa; Smajs David; Marsh Michael; McLoughlin Melanie; Norris Steven J; Weinstock George M; Palzkill Timothy
Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery.
Genome research 2003;13(7):1665-74.
2003: Materon Isabel C; Queenan Anne Marie; Koehler Theresa M; Bush Karen; Palzkill Timothy
Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis.
Antimicrobial agents and chemotherapy 2003;47(6):2040-2.
2003: Majiduddin Fahd K; Palzkill Timothy
Amino acid sequence requirements at residues 69 and 238 for the SME-1 beta-lactamase to confer resistance to beta-lactam antibiotics.
Antimicrobial agents and chemotherapy 2003;47(3):1062-7.
2003: Majiduddin Fahd K; Palzkill Timothy
An analysis of why highly similar enzymes evolve differently.
Genetics 2003;163(2):457-66.
2003: Rudgers Gary W; Palzkill Timothy
Minimization of proteins by random fragmentation and selection.
Methods in molecular biology (Clifton, N.J.) 2003;230():71-81.
2002: Reid Sean D; Green Nicole M; Sylva Gail L; Voyich Jovanka M; Stenseth Elisha T; DeLeo Frank R; Palzkill Timothy; Low Donald E; Hill Harry R; Musser James M
Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response.
Journal of bacteriology 2002;184(22):6316-24.
2002: Majiduddin Fahd K; Materon Isabel C; Palzkill Timothy G
Molecular analysis of beta-lactamase structure and function.
International journal of medical microbiology : IJMM 2002;292(2):127-37.
2002: Palzkill Timothy
Finding new antibiotics: the power of computational methods.
Drug discovery today 2002;7(6):347-8.
2002: Smajs David; McKevitt Matthew; Wang Ling; Howell Jerrilyn K; Norris Steven J; Palzkill Timothy; Weinstock George M
BAC library of T. pallidum DNA in E. coli.
Genome research 2002;12(3):515-22.
2001: Materon I C; Palzkill T
Identification of residues critical for metallo-beta-lactamase function by codon randomization and selection.
Protein science : a publication of the Protein Society 2001;10(12):2556-65.
2001: Rudgers G W; Huang W; Palzkill T
Binding properties of a peptide derived from beta-lactamase inhibitory protein.
Antimicrobial agents and chemotherapy 2001;45(12):3279-86.
2001: Zhang Z; Yu Y; Musser J M; Palzkill T
Amino acid sequence determinants of extended spectrum cephalosporin hydrolysis by the class C P99 beta-lactamase.
The Journal of biological chemistry 2001;276(49):46568-74.
2001: Rudgers G W; Palzkill T
Protein minimization by random fragmentation and selection.
Protein engineering 2001;14(7):487-92.
2001: Palzkill T
Impending doom: antibiotic exposure and bacterial gene expression.
Genome research 2001;11(1):1-2.
2001: Sideraki V; Huang W; Palzkill T; Gilbert H F
A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(1):283-8.
2000: Hoe N P; Kordari P; Cole R; Liu M; Palzkill T; Huang W; McLellan D; Adams G J; Hu M; Vuopio-Varkila J; Cate T R; Pichichero M E; Edwards K M; Eskola J; Low D E; Musser J M
Human immune response to streptococcal inhibitor of complement, a serotype M1 group A Streptococcus extracellular protein involved in epidemics.
The Journal of infectious diseases 2000;182(5):1425-36.
2000: Huang W; McKevitt M; Palzkill T
Use of the arabinose p(bad) promoter for tightly regulated display of proteins on bacteriophage.
Gene 2000;251(2):187-97.
2000: Huang W; Zhang Z; Palzkill T
Design of potent beta-lactamase inhibitors by phage display of beta-lactamase inhibitory protein.
The Journal of biological chemistry 2000;275(20):14964-8.
1999: Petrosino J F; Baker M; Palzkill T
Susceptibility of beta-lactamase to core amino acid substitutions.
Protein engineering 1999;12(9):761-9.
1999: Rudgers G W; Palzkill T
Identification of residues in beta-lactamase critical for binding beta-lactamase inhibitory protein.
The Journal of biological chemistry 1999;274(11):6963-71.
1999: Petrosino J; Rudgers G; Gilbert H; Palzkill T
Contributions of aspartate 49 and phenylalanine 142 residues of a tight binding inhibitory protein of beta-lactamases.
The Journal of biological chemistry 1999;274(4):2394-400.
1998: Huang W; Petrosino J; Palzkill T
Display of functional beta-lactamase inhibitory protein on the surface of M13 bacteriophage.
Antimicrobial agents and chemotherapy 1998;42(11):2893-7.
1998: Palzkill T; Huang W; Weinstock G M
Mapping protein-ligand interactions using whole genome phage display libraries.
Gene 1998;221(1):79-83.
1998: Cantu C; Palzkill T
The role of residue 238 of TEM-1 beta-lactamase in the hydrolysis of extended-spectrum antibiotics.
The Journal of biological chemistry 1998;273(41):26603-9.
1998: Petrosino J; Cantu C; Palzkill T
beta-Lactamases: protein evolution in real time.
Trends in microbiology 1998;6(8):323-7.
1997: Cantu C; Huang W; Palzkill T
Cephalosporin substrate specificity determinants of TEM-1 beta-lactamase.
The Journal of biological chemistry 1997;272(46):29144-50.
1997: Huang W; Palzkill T
A natural polymorphism in beta-lactamase is a global suppressor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(16):8801-6.
1996: Cantu C; Huang W; Palzkill T
Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime.
The Journal of biological chemistry 1996;271(37):22538-45.
1996: Huang W; Petrosino J; Hirsch M; Shenkin P S; Palzkill T
Amino acid sequence determinants of beta-lactamase structure and activity.
Journal of molecular biology 1996;258(4):688-703.
1996: Petrosino J F; Palzkill T
Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase.
Journal of bacteriology 1996;178(7):1821-8.
1995: Palzkill T; Thomson K S; Sanders C C; Moland E S; Huang W; Milligan T W
New variant of TEM-10 beta-lactamase gene produced by a clinical isolate of proteus mirabilis.
Antimicrobial agents and chemotherapy 1995;39(5):1199-200.
1994: Huang W; Le Q Q; LaRocco M; Palzkill T
Effect of threonine-to-methionine substitution at position 265 on structure and function of TEM-1 beta-lactamase.
Antimicrobial agents and chemotherapy 1994;38(10):2266-9.
1994: Venkatachalam K V; Huang W; LaRocco M; Palzkill T
Characterization of TEM-1 beta-lactamase mutants from positions 238 to 241 with increased catalytic efficiency for ceftazidime.
The Journal of biological chemistry 1994;269(38):23444-50.
1994: Palzkill T; Le Q Q; Venkatachalam K V; LaRocco M; Ocera H
Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of beta-lactamase.
Molecular microbiology 1994;12(2):217-29.
1994: Klann A G; Hull R A; Palzkill T; Hull S I
Alanine-scanning mutagenesis reveals residues involved in binding of pap-3-encoded pili.
Journal of bacteriology 1994;176(8):2312-7.
1994: Palzkill T; Le Q Q; Wong A; Botstein D
Selection of functional signal peptide cleavage sites from a library of random sequences.
Journal of bacteriology 1994;176(3):563-8.

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Timothy Palzkill

Research Profile (preview)

Chemicals & Drugs

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Phenomena

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Network (preview)

Publications

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All Publications