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Reinald Pamplona

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Oxidative Stress

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Lorena Arranz; Mónica De la Fuente; Alba Naudí; Reinald Pamplona
Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage.
Mariona Jové; Reinald Pamplona; Omar Ramírez-Núñez; José C E Serrano; Lluís Arola; Victoria Ayala; Antoni Caimari; Anna Cassanyé; Anna Crescenti; Josep M Del Bas; Manuel Portero-Otín
Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters.
José C E Serrano; Jordi Boada; Anna Cassanyé; Marco A Delgado; Alberto E Espinel; Stéphane Fourcade; Hugo Gonzalo-Benito; Mariona Jové; Reinald Pamplona; Manuel Portero-Otín
Dietary intake of green tea polyphenols regulates insulin sensitivity with an increase in AMP-activated protein kinase α content and changes in mitochondrial respiratory complexes.

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All Publications

2013: Lorena Arranz; Mónica De la Fuente; Alba Naudí; Reinald Pamplona
Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage.
Age (Dordrecht, Netherlands) 2013;35(3):621-35.
2013: Mariona Jové; Reinald Pamplona; Omar Ramírez-Núñez; José C E Serrano; Lluís Arola; Victoria Ayala; Antoni Caimari; Anna Cassanyé; Anna Crescenti; Josep M Del Bas; Manuel Portero-Otín
Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters.
Cardiovascular research 2013;97(4):642-52.
2013: José C E Serrano; Jordi Boada; Anna Cassanyé; Marco A Delgado; Alberto E Espinel; Stéphane Fourcade; Hugo Gonzalo-Benito; Mariona Jové; Reinald Pamplona; Manuel Portero-Otín
Dietary intake of green tea polyphenols regulates insulin sensitivity with an increase in AMP-activated protein kinase α content and changes in mitochondrial respiratory complexes.
Molecular nutrition & food research 2013;57(3):459-70.
2013: Alba Naudí; Manuel Portero-Otín; Victoria Ayala; Gustavo Barja; Rosanna Cabre; Daniel Cacabelos; Pilar Caro; José Gomez; Mariona Jové; Reinald Pamplona
Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction.
Amino acids 2013;44(2):361-71.
2013: Alba Naudí; Victoria Ayala; Rosanna Cabré; Mariona Jové; Manuel Portero-Otín; Reinald Pamplona
Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions.
International journal of molecular sciences 2013;14(2):3285-313.
2013: Bodil Bjørndal; Daniel Cacabelos; Tore Grimstad; Trygve Hausken; Gülen Arslan Lied; Kim Nylund; Roald Omdal; Reinald Pamplona; Manuel Portero-Otin; Ole Gunnar Aasprong; Rolf K Berge
Tetradecylthioacetic acid attenuates inflammation and has antioxidative potential during experimental colitis in rats.
Digestive diseases and sciences 2013;58(1):97-106.
2012: Hugo Gonzalo; Lourdes Hernández; Mariona Jové; Lucia Lanau-Angulo; Reinald Pamplona; Sílvia Peralta; Jordi Boada; Luis Brieva; Daniel Cacabelos; Anna Cassanyé; Cristina González; José C E Serrano; Franz Tatzber; Manuel Portero-Otin
Lipidome analysis in multiple sclerosis reveals protein lipoxidative damage as a potential pathogenic mechanism.
Journal of neurochemistry 2012;123(4):622-34.
2012: Natalya Filipchuk Vigerust; Asgaut Viste; Hege Wergedahl; Kjetil Berge; Rolf Kristian Berge; Lena Burri; Daniel Cacabelos; Bjørn Christensen; Reinald Pamplona; Manuel Portero-Otin; Bodil Bjørndal
Fish oil and 3-thia fatty acid have additive effects on lipid metabolism but antagonistic effects on oxidative damage when fed to rats for 50 weeks.
The Journal of nutritional biochemistry 2012;23(11):1384-93.
2012: Rhoda Stefanatos; Ashwin Sriram; Victoria Ayala; Howard T Jacobs; Essi Kiviranta; Aravind Mohan; Reinald Pamplona; Alberto Sanz
dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.
Cell cycle (Georgetown, Tex.) 2012;11(20):3876-86.
2012: Elena Galea; Nathalie Launay; Reinald Pamplona; Manuel Portero-Otin; Patrick Aubourg; Isidre Ferrer; Montserrat Ruiz; Aurora Pujol
Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: a paradigm for multifactorial neurodegenerative diseases?
Biochimica et biophysica acta 2012;1822(9):1475-88.
2012: Ester Aso; Margarita Carmona; Mario Díaz; Núria Fernández-Yagüe; Laura Joda; Salvador Juvés; Selene Lomoio; Irene López-González; Virginia Martín; Jesús Moreno; Reinald Pamplona; Manuel Portero-Otin; Aurora Pujol; Isidro Ferrer
Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease.
Brain pathology (Zurich, Switzerland) 2012;22(5):636-53.
2012: Inés Sanchez-Roman; Henar Suarez; Alexia Gómez; Mariona Jové; Mónica Lopez-Torres; Alba Naudí; Reinald Pamplona; Irene Pérez; Carlota Sanchez; Gustavo Barja
Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria.
Biogerontology 2012;13(4):399-411.
2012: Arantza Soler-Cantero; Josep Valls; Lluis Arola; Maria Josep Bellmunt; Jordi Boada; Daniel Cacabelos; Anna Cassanyé; Mariona Jové; Alba Naudí; Reinald Pamplona; Manuel Portero-Otin; Joan Prat; Maria-Paz Romero; José C E Serrano; Maria-José Motilva
Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications.
PloS one 2012;7(8):e43308.
2012: Alba Naudi; Manuel Portero-Otin; Joan Prat; Jose Serrano; Victoria Ayala; Jordi Boada; Anna Cassanye; Hugo Gonzalo; Mariona Jove; Reinald Pamplona
Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.
Experimental diabetes research 2012;2012():696215.
2011: Jorge Galino; Elena García-Arumí; Cristina Guilera; Mariona Jove; Jone López-Erauskin; Alba Naudi; Reinald Pamplona; Manuel Portero-Otin; Antoni L Andreu; Isidre Ferrer; Stéphane Fourcade; Montserrat Ruiz; Agatha Schlüter; anatoly starkov; Aurora Pujol
Oxidative damage compromises energy metabolism in the axonal degeneration mouse model of X-adrenoleukodystrophy.
Antioxidants & redox signaling 2011;15(8):2095-107.
2011: Reinald Pamplona; David Costantini
Molecular and structural antioxidant defenses against oxidative stress in animals.
American journal of physiology. Regulatory, integrative and comparative physiology 2011;301(4):R843-63.
2011: Reinald Pamplona; Gustavo Barja
An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms.
Biogerontology 2011;12(5):409-35.
2011: Victoria Ayala; Jordi Boada; Daniel Cacabelos; Víctor Caraballo-Miralles; Isidro Ferrer; Ana Belén Granado-Serrano; Ekaterina V Ilieva; Jerònia Lladó; Alba Naudí; Reinald Pamplona; Manuel Portero-Otin
Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.
Acta neuropathologica 2011;122(3):259-70.
2011: Mariona Jové; José-Ramón Morelló; Maria-José Motilva; Nàdia Ortega; Reinald Pamplona; Joan Prat; Jordi Reguant; Maria-Paz Romero; José C E Serrano; Neus Anglès; Victoria Ayala; Manuel Portero-Otín
Multicompartmental LC-Q-TOF-based metabonomics as an exploratory tool to identify novel pathways affected by polyphenol-rich diets in mice.
Journal of proteome research 2011;10(8):3501-12.
2011: Jone López-Erauskin; Alba Naudi; Reinald Pamplona; Manuel Portero-Otin; Isidre Ferrer; Stéphane Fourcade; Jorge Galino; Mariona Jove; Montserrat Ruiz; Agatha Schlüter; Aurora Pujol
Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.
Annals of neurology 2011;70(1):84-92.
2011: Reinald Pamplona
Advanced lipoxidation end-products.
Chemico-biological interactions 2011;192(1-2):14-20.
2011: Julio J Ochoa; Reinald Pamplona; M Carmen Ramirez-Tortosa; Sergio Granados-Principal; Patricia Perez-Lopez; Alba Naudí; Manuel Portero-Otin; Magdalena López-Frías; Maurizio Battino; José L Quiles
Age-related changes in brain mitochondrial DNA deletion and oxidative stress are differentially modulated by dietary fat type and coenzyme Q₁₀.
Free radical biology & medicine 2011;50(9):1053-64.
2011: Ekaterina V Ilieva; Anton Kichev; Alba Naudí; Isidre Ferrer; Reinald Pamplona; Manuel Portero-Otín
Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease.
Journal of neuropathology and experimental neurology 2011;70(4):253-63.
2011: Ana Saborido; Alba Naudí; Manuel Portero-Otín; Reinald Pamplona; Alicia Megías
Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985) 2011;110(3):661-9.
2011: Reinald Pamplona
Mitochondrial DNA damage and animal longevity: insights from comparative studies.
Journal of aging research 2011;2011():807108.
2011: Alberto del Arco; Gregorio Segovia; Marta de Blas; Pedro Garrido; Dario Acuña-Castroviejo; Reinald Pamplona; Francisco Mora
Prefrontal cortex, caloric restriction and stress during aging: studies on dopamine and acetylcholine release, BDNF and working memory.
Behavioural brain research 2011;216(1):136-45.
2010: Ines Sanchez-Roman; Jose Gomez; Alba Naudi; Victoria Ayala; Manuel Portero-Otín; Monica Lopez-Torres; Reinald Pamplona; Gustavo Barja
The β-blocker atenolol lowers the longevity-related degree of fatty acid unsaturation, decreases protein oxidative damage, and increases extracellular signal-regulated kinase signaling in the heart of C57BL/6 mice.
Rejuvenation research 2010;13(6):683-93.
2010: Anne Negre-Salvayre; Nathalie Auge; Victoria Ayala; Huveyda Basaga; Jordi Boada; Rainer Brenke; Sarah Chapple; gUY Cohen; Janos Feher; Tilman Grune; Gabriella Lengyel; Giovanni E Mann; Reinald Pamplona; Giuseppe Poli; Manuel Portero-Otin; Yael Riahi; Robert Salvayre; Shlomo Sasson; Jose Serrano; Ofer Shamni; Werner Siems; Richard C M Siow; Ingrid Wiswedel; Kamelija Zarkovic; Neven Zarkovic
Pathological aspects of lipid peroxidation.
Free radical research 2010;44(10):1125-71.
2010: Jake Jacobson; Adrian J Lambert; Manuel Portero-Otín; Reinald Pamplona; Tapiwanashe Magwere; Satomi Miwa; Yasmine Driege; Martin D Brand; Linda Partridge
Biomarkers of aging in Drosophila.
Aging cell 2010;9(4):466-77.
2010: Reinald Pamplona
[Dietary restriction and aging: a matter of calories?].
Revista española de geriatría y gerontología 2010;45(4):232-8.
2010: Alberto Sanz; Mikko Soikkeli; Manuel Portero-Otín; Angela Wilson; Esko Kemppainen; George McIlroy; Simo Ellilä; Kia K Kemppainen; Tea Tuomela; Matti Lakanmaa; Essi Kiviranta; Rhoda Stefanatos; Eric Dufour; Bettina Hutz; Alba Naudí; Mariona Jové; Akbar Zeb; Suvi Vartiainen; Akemi Matsuno-Yagi; Takao Yagi; Pierre Rustin; Reinald Pamplona; Howard T Jacobs
Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(20):9105-10.
2010: Stéphane Fourcade; Montserrat Ruiz; Cristina Guilera; eric hahnen; Lars Brichta; Alba Naudi; Manuel Portero-Otín; Georges Dacremont; Nathalie Cartier; Ronald Wanders; Stephan Kemp; Jean Louis Mandel; Brunhilde Wirth; Reinald Pamplona; Patrick Aubourg; Aurora Pujol
Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy.
Human molecular genetics 2010;19(10):2005-14.
2010: Ekaterina V Ilieva; Alba Naudí; Anton Kichev; Isidre Ferrer; Reinald Pamplona; Manuel Portero-Otín
Depletion of oxidative and endoplasmic reticulum stress regulators in Pick disease.
Free radical biology & medicine 2010;48(10):1302-10.
2010: Alba Naudí; Mariona Jové; Victoria Ayala; Manuel Portero-Otín; Reinald Pamplona
[Glycation of mitochondrial proteins, oxidative stress and aging].
Revista española de geriatría y gerontología 2010;45(3):156-66.
2010: Anna Martinez; Manuel Portero-Otin; Reinald Pamplona; Isidre Ferrer
Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates.
Brain pathology (Zurich, Switzerland) 2010;20(2):281-97.
2010: Asimina Hiona; Alberto Sanz; Gregory C Kujoth; Reinald Pamplona; Arnold Y Seo; Tim Hofer; Shinichi Someya; Takuya Miyakawa; Chie Nakayama; Alejandro K Samhan-Arias; Stephane Servais; Jamie L Barger; Manuel Portero-Otín; Masaru Tanokura; Tomas A Prolla; Christiaan Leeuwenburgh
Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.
PloS one 2010;5(7):e11468.
2010: Mariona Jové; José C E Serrano; Maria Josep Bellmunt; Anna Cassanyé; Neus Anglès; Jordi Reguant; José-Ramón Morelló; Reinald Pamplona; Manuel Portero-Otín
When cholesterol is not cholesterol: a note on the enzymatic determination of its concentration in model systems containing vegetable extracts.
Lipids in health and disease 2010;9():65.
2010: José Serrano; Ana Cipak; Jordi Boada; Hugo Gonzalo; Daniel Cacabelos; Anna Cassanye; Reinald Pamplona; Neven Zarkovic; Manuel Portero-Otin
Double-edged sword behaviour of gallic acid and its interaction with peroxidases in human microvascular endothelial cell culture (HMEC-1). Antioxidant and pro-oxidant effects.
Acta biochimica Polonica 2010;57(2):193-8.
2010: Liana Lisboa Fernandez; Marga Carmona; Manuel Portero-Otin; Alba Naudi; Reinald Pamplona; Nadja Schröder; Isidro Ferrer
Effects of increased iron intake during the neonatal period on the brain of adult AbetaPP/PS1 transgenic mice.
Journal of Alzheimer's disease : JAD 2010;19(3):1069-80.
2010: José L Quiles; Reinald Pamplona; M Carmen Ramirez-Tortosa; Alba Naudí; Manuel Portero-Otin; Eduardo Araujo-Nepomuceno; Magdalena López-Frías; Maurizio Battino; Julio J Ochoa
Coenzyme Q addition to an n-6 PUFA-rich diet resembles benefits on age-related mitochondrial DNA deletion and oxidative stress of a MUFA-rich diet in rat heart.
Mechanisms of ageing and development 2010;131(1):38-47.
2010: Gerard Muntané; Anna Janué; Nuria Fernandez; Maria Antonia Odena; Eliandre Oliveira; Susana Boluda; Manuel Portero-Otin; Alba Naudí; Jordi Boada; Reinald Pamplona; Isidre Ferrer
Modification of brain lipids but not phenotype in alpha-synucleinopathy transgenic mice by long-term dietary n-3 fatty acids.
Neurochemistry international 2010;56(2):318-28.
2010: Beatrice Terni; Jordi Boada; Manuel Portero-Otin; Reinald Pamplona; Isidro Ferrer
Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology.
Brain pathology (Zurich, Switzerland) 2010;20(1):222-33.
2009: Pilar Caro; Jose Gomez; Ines Sanchez; Alba Naudi; Victoria Ayala; Mónica López-Torres; Reinald Pamplona; Gustavo Barja
Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondria.
Rejuvenation research 2009;12(6):421-34.
2009: Anton Kichev; Ekaterina V Ilieva; Gerard Piñol-Ripoll; Petar Podlesniy; Isidro Ferrer; Manuel Portero-Otín; Reinald Pamplona; Carme Espinet
Cell death and learning impairment in mice caused by in vitro modified pro-NGF can be related to its increased oxidative modifications in Alzheimer disease.
The American journal of pathology 2009;175(6):2574-85.
2009: Anne Negre-Salvayre; Robert Salvayre; Nathalie Augé; Reinald Pamplona; Manuel Portero-Otín
Hyperglycemia and glycation in diabetic complications.
Antioxidants & redox signaling 2009;11(12):3071-109.
2009: José Serrano; Mariona Jové; Jordi Boada; María Josep Bellmunt; Reinald Pamplona; Manuel Portero-Otín
Dietary antioxidants interfere with Amplex Red-coupled-fluorescence assays.
Biochemical and biophysical research communications 2009;388(2):443-9.
2009: Pilar Caro; Jose Gomez; Inés Sanchez; Ruben Garcia; Mónica López-Torres; Alba Naudí; Manuel Portero-Otin; Reinald Pamplona; Gustavo Barja
Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver.
Biogerontology 2009;10(5):579-92.
2009: Jose Gomez; Pilar Caro; Ines Sanchez; Alba Naudi; Mariona Jove; Manuel Portero-Otin; Monica Lopez-Torres; Reinald Pamplona; Gustavo Barja
Effect of methionine dietary supplementation on mitochondrial oxygen radical generation and oxidative DNA damage in rat liver and heart.
Journal of bioenergetics and biomembranes 2009;41(3):309-21.
2008: Anna Martinez; Margarita Carmona; Manuel Portero-Otin; Alba Naudí; Reinald Pamplona; Isidre Ferrer
Type-dependent oxidative damage in frontotemporal lobar degeneration: cortical astrocytes are targets of oxidative damage.
Journal of neuropathology and experimental neurology 2008;67(12):1122-36.
2008: Reinald Pamplona; Alba Naudí; Rosalina Gavín; Miguel A Pastrana; Gustavo Sajnani; Ekaterina V Ilieva; José Antonio Del Río; Manuel Portero-Otín; Isidre Ferrer; Jesús R Requena
Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease.
Free radical biology & medicine 2008;45(8):1159-66.
2008: Reinald Pamplona
Membrane phospholipids, lipoxidative damage and molecular integrity: a causal role in aging and longevity.
Biochimica et biophysica acta 2008;1777(10):1249-62.
2008: Stéphane Fourcade; Jone López-Erauskin; Jorge Galino; Carine Duval; Alba Naudi; Mariona Jove; Stephan Kemp; Francesc Villarroya; Isidro Ferrer; Reinald Pamplona; Manuel Portero Otin; Aurora Pujol
Early oxidative damage underlying neurodegeneration in X-adrenoleukodystrophy.
Human molecular genetics 2008;17(12):1762-73.
2008: Pilar Caro; José Gómez; Mónica López-Torres; Inés Sánchez; Alba Naudi; Manuel Portero-Otín; Reinald Pamplona; Gustavo Barja
Effect of every other day feeding on mitochondrial free radical production and oxidative stress in mouse liver.
Rejuvenation research 2008;11(3):621-9.
2008: Pilar Caro; José Gómez; Mónica López-Torres; Inés Sánchez; Alba Naudí; Mariona Jove; Reinald Pamplona; Gustavo Barja
Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver.
Biogerontology 2008;9(3):183-96.
2008: Manuel Portero-Otín; Reinald Pamplona; Jordi Boada; Mariona Jové; Hugo Gonzalo; Marie Buleon; Wolfgang Linz; Stefan Schäfer; Ivan Tack; Jean-Pierre Girolami
Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats.
Biochemical and biophysical research communications 2008;368(3):528-35.
2008: Reinald Pamplona; Ekaterina Ilieva; Victoria Ayala; Maria Josep Bellmunt; Daniel Cacabelos; Esther Dalfo; Isidro Ferrer; Manuel Portero Otin
Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes.
Annals of the New York Academy of Sciences 2008;1126():315-9.
2007: Ekaterina V Ilieva; Victoria Ayala; Mariona Jové; Esther Dalfó; Daniel Cacabelos; Mónica Povedano; Maria Josep Bellmunt; Isidro Ferrer; Reinald Pamplona; Manuel Portero-Otín
Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis.
Brain : a journal of neurology 2007;130(Pt 12):3111-23.
2007: Alba Naudí; Pilar Caro; Mariona Jové; José Gómez; Jordi Boada; Victoria Ayala; Manuel Portero-Otín; Gustavo Barja; Reinald Pamplona
Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain.
Rejuvenation research 2007;10(4):473-84.
2007: Anthony J Hulbert; Reinald Pamplona; Rochelle Buffenstein; William A Buttemer
Life and death: metabolic rate, membrane composition, and life span of animals.
Physiological reviews 2007;87(4):1175-213.
2007: Reinald Pamplona; Gustavo Barja
Highly resistant macromolecular components and low rate of generation of endogenous damage: two key traits of longevity.
Ageing research reviews 2007;6(3):189-210.
2007: Anne-Valerie Cantero; Manuel Portero-Otín; Victoria Ayala; Nathalie Auge; Marie Sanson; Meyer Elbaz; Jean-Claude Thiers; Reinald Pamplona; Robert Salvayre; Anne Nègre-Salvayre
Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(12):3096-106.
2007: José Gómez; Pilar Caro; Alba Naudí; Manuel Portero Otin; Reinald Pamplona; Gustavo Barja
Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver.
Biogerontology 2007;8(5):555-66.
2007: Victoria Ayala; Alba Naudí; Alberto Sanz; Pilar Caro; Manuel Portero Otin; Gustavo Barja; Reinald Pamplona
Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver.
The journals of gerontology. Series A, Biological sciences and medical sciences 2007;62(4):352-60.
2007: Pilar Caro; José Gómez; Alberto Sanz; Manuel Portero-Otín; Reinald Pamplona; Gustavo Barja
Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria.
Biogerontology 2007;8(1):1-11.
2006: Gerard Muntané; Esther Dalfó; Anna Martinez; María Jesús Rey; Jesús Avila; M Pérez; M Portero; Reinald Pamplona; Victoria Ayala; Isidro Ferrer
Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease.
Journal of neurochemistry 2006;99(1):177-85.
2006: Alberto Sanz; Pilar Caro; Victoria Ayala; Manuel Portero Otin; Reinald Pamplona; Gustavo Barja
Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1064-73.
2006: Reinald Pamplona; Gustavo Barja
Mitochondrial oxidative stress, aging and caloric restriction: the protein and methionine connection.
Biochimica et biophysica acta 2006;1757(5-6):496-508.
2006: M Sorensen; A Sanz; J Gómez; Reinald Pamplona; Manuel Portero-Otín; Ricardo Gredilla; Gustavo Barja
Effects of fasting on oxidative stress in rat liver mitochondria.
Free radical research 2006;40(4):339-47.
2006: Alberto Sanz; Reinald Pamplona; Gustavo Barja
Is the mitochondrial free radical theory of aging intact?
Antioxidants & redox signaling 2006;8(3-4):582-99.
2006: Paola Venditti; Reinald Pamplona; Manuel Portero Otin; Raffaella De Rosa; Sergio Di Meo
Effect of experimental and cold exposure induced hyperthyroidism on H2O2 production and susceptibility to oxidative stress of rat liver mitochondria.
Archives of biochemistry and biophysics 2006;447(1):11-22.
2006: Paola Venditti; Reinald Pamplona; Victoria Ayala; Raffaella De Rosa; G Caldarone; Sergio Di Meo
Differential effects of experimental and cold-induced hyperthyroidism on factors inducing rat liver oxidative damage.
The Journal of experimental biology 2006;209(Pt 5):817-25.
2006: Tapiwanashe Magwere; Reinald Pamplona; Satomi Miwa; Pedro Martinez-Diaz; Manuel Portero Otin; Martin D Brand; Linda Partridge
Flight activity, mortality rates, and lipoxidative damage in Drosophila.
The journals of gerontology. Series A, Biological sciences and medical sciences 2006;61(2):136-45.
2005: Reinald Pamplona; Manuel Portero-Otín; Alberto Sanz; Ekaterina Vasileva; Victoria Ayala; Gustavo Barja
Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate.
Age (Dordrecht, Netherlands) 2005;27(4):267-80.
2005: Maria Cristina Ruiz; Victoria Ayala; Manuel Portero-Otín; Jesús R Requena; Gustavo Barja; Reinald Pamplona
Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals.
Mechanisms of ageing and development 2005;126(10):1106-14.
2005: Esther Dalfó; Manuel Portero-Otín; Victoria Ayala; Anna Martinez; Reinald Pamplona; Isidro Ferrer
Evidence of oxidative stress in the neocortex in incidental Lewy body disease.
Journal of neuropathology and experimental neurology 2005;64(9):816-30.
2005: Reinald Pamplona; Esther Dalfó; Victoria Ayala; Maria Josep Bellmunt; Joan Prat; Isidro Ferrer; Manuel Portero-Otín
Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets.
The Journal of biological chemistry 2005;280(22):21522-30.
2005: Alberto Sanz; Ricardo Gredilla; Reinald Pamplona; Manuel Portero-Otín; Elena Vara; J A F Tresguerres; Gustavo Barja
Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals.
Biogerontology 2005;6(1):15-26.
2004: Manuel Portero-Otín; Jesús R Requena; Maria Josep Bellmunt; Victoria Ayala; Reinald Pamplona
Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon.
Experimental gerontology 2004;39(10):1527-35.
2004: Reinald Pamplona; Manuel Portero Otin
Advanced glycation end products in urine: are some sugar-derived products better than others?
The Journal of laboratory and clinical medicine 2004;144(2):58-9.
2004: Adrian J Lambert; Manuel Portero Otin; Reinald Pamplona; Brian J Merry
Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria.
Mechanisms of ageing and development 2004;125(8):529-38.
2004: Paola Venditti; Raffaella De Rosa; Manuel Portero Otin; Reinald Pamplona; Sergio Di Meo
Cold-induced hyperthyroidism produces oxidative damage in rat tissues and increases susceptibility to oxidants.
The international journal of biochemistry & cell biology 2004;36(7):1319-31.
2004: Reinald Pamplona; Manuel Portero Otin; Alberto Sanz; Jesús R Requena; Gustavo Barja
Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain.
Experimental gerontology 2004;39(5):725-33.
2003: Manuel Portero Otin; Maria Josep Bellmunt; Jesús R Requena; Reinald Pamplona
Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids.
Biochemical Society transactions 2003;31(Pt 6):1403-5.
2003: Karim S Echtay; Telma C Esteves; Julian L Pakay; Mika B Jekabsons; Adrian J Lambert; Manuel Portero-Otín; Reinald Pamplona; Antonio Vidal-Puig; Steven Wang; Stephen J Roebuck; Martin D Brand
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling.
The EMBO journal 2003;22(16):4103-10.
2003: Maria Cristina Ruiz; Manuel Portero-Otín; Reinald Pamplona; Jesús R Requena; Joan Prat; Maria Antonieta Lafarga; Mercè Borràs; Maria Josep Bellmunt
Chemical and immunological characterization of oxidative nonenzymatic protein modifications in dialysis fluids.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 2003;23(1):23-32.
2002: Martin D Brand; Reinald Pamplona; Manuel Portero-Otín; Jesús R Requena; Stephen J Roebuck; Julie A Buckingham; John Clapham; Susana Cadenas
Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3.
The Biochemical journal 2002;368(Pt 2):597-603.
2002: Reinald Pamplona; Manuel Portero-Otín; Jesús R Requena; Ricardo Gredilla; Gustavo Barja
Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.
Mechanisms of ageing and development 2002;123(11):1437-46.
2002: Manuel Portero-Otín; Reinald Pamplona; Maria Josep Bellmunt; Maria Cristina Ruiz; Joan Prat; Robert Salvayre; Anne Nègre-Salvayre
Advanced glycation end product precursors impair epidermal growth factor receptor signaling.
Diabetes 2002;51(5):1535-42.
2002: Reinald Pamplona; Gustavo Barja; Manuel Portero-Otín
Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation?
Annals of the New York Academy of Sciences 2002;959():475-90.
2002: Teresa Doñate; Alba Herreros; Ester Martinez; Joaquin Martinez; Enric Andrés; Antonio Cabezas; Angeles Ortiz; Ana de Prado; Josep Maria Pou; Reinald Pamplona; Manuel Portero Otin; Maria J Bellmunt
Protein oxidative stress in dialysis patients.
Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 2002;18():15-7.
2002: Reinald Pamplona; Manuel Portero-Otín; Maria Josep Bellmun; Ricardo Gredilla; Gustavo Barja
Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins.
Free radical research 2002;36(1):47-54.
2001: Ricardo Gredilla; Mónica López-Torres; Manuel Portero-Otín; Reinald Pamplona; Gustavo Barja
Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle.
Molecular and cellular biochemistry 2001;221(1-2):41-8.
2001: Manuel Portero-Otín; Maria Josep Bellmunt; Maria Cristina Ruiz; Gustavo Barja; Reinald Pamplona
Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential.
Lipids 2001;36(5):491-8.
2001: A Herrero; Manuel Portero-Otín; Maria Josep Bellmunt; Reinald Pamplona; Gustavo Barja
Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage.
Mechanisms of ageing and development 2001;122(4):427-43.
2000: Reinald Pamplona; Manuel Portero-Otín; D Riba; Jesús R Requena; Suzanne R Thorpe; Mónica López-Torres; Gustavo Barja
Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans.
The journals of gerontology. Series A, Biological sciences and medical sciences 2000;55(6):B286-91.
2000: Reinald Pamplona; Manuel Portero-Otín; C Ruiz; Ricardo Gredilla; A Herrero; Gustavo Barja
Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals.
Mechanisms of ageing and development 2000;112(3):169-83.
1999: Manuel Portero-Otín; Reinald Pamplona; Maria Cristina Ruiz; Elisa Cabiscol; Joan Prat; Maria Josep Bellmunt
Diabetes induces an impairment in the proteolytic activity against oxidized proteins and a heterogeneous effect in nonenzymatic protein modifications in the cytosol of rat liver and kidney.
Diabetes 1999;48(11):2215-20.
1999: Reinald Pamplona; Manuel Portero-Otín; C Ruiz; Maria Josep Bellmunt; Jesús R Requena; Suzanne R Thorpe; John W Baynes; M Romero; Mónica López-Torres; Gustavo Barja
Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins.
Free radical biology & medicine 1999;27(7-8):901-10.
1999: Reinald Pamplona; Manuel Portero-Otín; D Riba; F Ledo; Ricardo Gredilla; A Herrero; Gustavo Barja
Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.
Aging (Milan, Italy) 1999;11(1):44-9.
1999: Reinald Pamplona; Manuel Portero-Otín; Jesús R Requena; Suzanne R Thorpe; A Herrero; Gustavo Barja
A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat.
Mechanisms of ageing and development 1999;106(3):283-96.
1999: A Guerrero; Reinald Pamplona; Manuel Portero-Otín; Gustavo Barja; Mónica López-Torres
Effect of thyroid status on lipid composition and peroxidation in the mouse liver.
Free radical biology & medicine 1999;26(1-2):73-80.
1998: Reinald Pamplona; Manuel Portero-Otín; D Riba; C Ruiz; Joan Prat; Maria Josep Bellmunt; Gustavo Barja
Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals.
Journal of lipid research 1998;39(10):1989-94.
1998: Reinald Pamplona; Jesús R Requena; Manuel Portero-Otín; Joan Prat; Suzanne R Thorpe; Maria Josep Bellmunt
Carboxymethylated phosphatidylethanolamine in mitochondrial membranes of mammals--evidence for intracellular lipid glycoxidation.
European journal of biochemistry / FEBS 1998;255(3):685-9.
1997: Manuel Portero-Otín; Reinald Pamplona; Maria Josep Bellmunt; M Bergua; Joan Prat
Glycaemic control and in vivo non-oxidative Maillard reaction: urinary excretion of pyrraline in diabetes patients.
European journal of clinical investigation 1997;27(9):767-73.
1997: Manuel Portero-Otín; Reinald Pamplona; Maria Josep Bellmunt; M Bergua; R H Nagaraj; Joan Prat
Urinary pyrraline as a biochemical marker of non-oxidative Maillard reactions in vivo.
Life sciences 1997;60(4-5):279-87.
1996: Gustavo Barja; S Cadenas; C Rojas; R Pérez-Campo; Mónica López-Torres; J Prat; Reinald Pamplona
Effect of dietary vitamin E levels on fatty acid profiles and nonenzymatic lipid peroxidation in the guinea pig liver.
Lipids 1996;31(9):963-70.
1996: Reinald Pamplona; J Prat; S Cadenas; C Rojas; R Pérez-Campo; Mónica López-Torres; Gustavo Barja
Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: the pigeon and human case.
Mechanisms of ageing and development 1996;86(1):53-66.
1995: Maria Josep Bellmunt; M Portero; Reinald Pamplona; L Cosso; Patrizio Odetti; Joan Prat
Evidence for the Maillard reaction in rat lung collagen and its relationship with solubility and age.
Biochimica et biophysica acta 1995;1272(1):53-60.
1995: Reinald Pamplona; Maria Josep Bellmunt; M Portero; D Riba; Joan Prat
Chromatographic evidence for Amadori product formation in rat liver aminophospholipids.
Life sciences 1995;57(9):873-9.
1995: Maria Josep Bellmunt; M Portero; Reinald Pamplona; M Muntaner; Joan Prat
Age-related fluorescence in rat lung collagen.
Lung 1995;173(3):177-85.
1994: Gustavo Barja; Mónica López-Torres; R Pérez-Campo; C Rojas; S Cadenas; J Prat; Reinald Pamplona
Dietary vitamin C decreases endogenous protein oxidative damage, malondialdehyde, and lipid peroxidation and maintains fatty acid unsaturation in the guinea pig liver.
Free radical biology & medicine 1994;17(2):105-15.
1993: C Rojas; S Cadenas; R Pérez-Campo; Mónica López-Torres; Reinald Pamplona; J Prat; Gustavo Barja
Relationship between lipid peroxidation, fatty acid composition, and ascorbic acid in the liver during carbohydrate and caloric restriction in mice.
Archives of biochemistry and biophysics 1993;306(1):59-64.
1993: Reinald Pamplona; Maria Josep Bellmunt; M Portero; Joan Prat
Mechanisms of glycation in atherogenesis.
Medical hypotheses 1993;40(3):174-81.