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Pier Paolo Pandolfi

Research Profile

Living Beings

Chemicals & Drugs

Disorders

Physiology

Genes & Molecular Sequences

Genes, Tumor Suppressor

Anatomy

Cells, Cultured

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Publications

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Ugo Ala; Carla Bosia; Florian A Karreth; Valentine Léopold; Andrea Pagnani; Paolo Provero; Riccardo Taulli; Yvonne Tay; Riccardo Zecchina; Pier Paolo Pandolfi
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments.
Andrea Lunardi; Takahiro Maeda; Jlenia Guarnerio; Guocan Wang; Pier Paolo Pandolfi
Role of LRF/Pokemon in lineage fate decisions.
Yan Liu; Ingo K Mellinghoff; Silvia Menendez; Yasuhiko Miyata; Pier Paolo Pandolfi; Neal Rosen; Goro Sashida; Qing-Bai She; Youyang Yang; Hao Yu; Xinyang Zhao; Zhenbang Chen; Anthony Deblasio; Silvana Di giandomenico; Shannon E Elf; Michael Harr; Cyrus V Hedvat; Gang Huang; Hui-Kuan Lin; Fan Liu; Stephen D Nimer
Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.

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All Publications

2013: Ugo Ala; Carla Bosia; Florian A Karreth; Valentine Léopold; Andrea Pagnani; Paolo Provero; Riccardo Taulli; Yvonne Tay; Riccardo Zecchina; Pier Paolo Pandolfi
Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):7154-9.
2013: Andrea Lunardi; Takahiro Maeda; Jlenia Guarnerio; Guocan Wang; Pier Paolo Pandolfi
Role of LRF/Pokemon in lineage fate decisions.
Blood 2013;121(15):2845-53.
2012: Yan Liu; Ingo K Mellinghoff; Silvia Menendez; Yasuhiko Miyata; Pier Paolo Pandolfi; Neal Rosen; Goro Sashida; Qing-Bai She; Youyang Yang; Hao Yu; Xinyang Zhao; Zhenbang Chen; Anthony Deblasio; Silvana Di giandomenico; Shannon E Elf; Michael Harr; Cyrus V Hedvat; Gang Huang; Hui-Kuan Lin; Fan Liu; Stephen D Nimer
Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.
Science signaling 2012;5(247):ra77.
2012: Antonella Papa; Rosa Bernardi; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Compound In Vivo Inactivation of Pml and p53 Uncovers a Functional Interaction in Angiosarcoma Suppression.
Genes & cancer 2012;3(9-10):599-603.
2012: Keisuke Ito; Chih-Hao Lee; Zachary T Schafer; Toshio Suda; Dror Weiss; Ugo Ala; Fumio Arai; David E Avigan; Arkaitz Carracedo; Ronald M Evans; Pier Paolo Pandolfi
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
Nature medicine 2012;18(9):1350-8.
2012: John G Clohessy; Markus Reschke; Pier Paolo Pandolfi
Found in translation of mTOR signaling.
Cell research 2012;22(9):1315-8.
2012: Kamil Wolyniec; Simone J Woods; Osnat Alsheich-Bartok; Vincent Corneille; Elisa de Stanchina; Stephen Fox; Sue Haupt; Yong-Hui Jiang; Ricky W Johnstone; Beena Kumar; Yaara Levav-Cohen; Igal Louria-Hayon; Scott W Lowe; Stephen Opat; Pier Paolo Pandolfi; Clare L Scott; David Segal; Jake Shortt; Andreas Strasser; Ygal Haupt
E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis.
Blood 2012;120(4):822-32.
2012: Pier Paolo Scaglioni; Thomas M Yung; Andrea Rabellino; Rosa Bernardi; Ke Cheng; Sooyeon Choi; Georgia Konstantinidou; Caterina Nardella; Pier Paolo Pandolfi
Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence.
EMBO molecular medicine 2012;4(7):594-602.
2012: Min Sup Song; Leonardo Salmena; Pier Paolo Pandolfi
The functions and regulation of the PTEN tumour suppressor.
Nature reviews. Molecular cell biology 2012;13(5):283-96.
2012: Isabel Garcia-Cao; Carlotta Giorgi; Marcia C Haigis; Robin M Hobbs; Keisuke Ito; Gaelle Laurent; Dimitrios Anastasiou; Lewis C Cantley; Arkaitz Carracedo; Vincent C J de Boer; Paolo Pinton; Lucia Rameh; Atsuo T Sasaki; Min Sup Song; Matthew G Vander Heiden; Pier Paolo Pandolfi
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Cell 2012;149(1):49-62.
2012: Robin M Hobbs; Ryuichi Nishinakamura; Fiorella Altruda; Li Chai; Sharmila Fagoonee; Antonella Papa; Kaitlyn Webster; Pier Paolo Pandolfi
Functional antagonism between Sall4 and Plzf defines germline progenitors.
Cell stem cell 2012;10(3):284-98.
2012: Ning Wang; Ronghua Ding; Gerald D Frank; Erwin J Landon; Pier Paolo Pandolfi; Amita Rachakonda; Takaaki Senbonmatsu; Zhongjia Tan; Tadashi Inagami
Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2.
PloS one 2012;7(4):e35632.
2011: Florian A Karreth; Michael Krauthammer; David J Adams; Ugo Ala; Gina DeNicola; Ruth Halaban; Pedro A Perez-Mancera; Daniele Perna; Paolo Provero; Alistair G Rust; Shen Mynn Tan; Yvonne Tay; David A Tuveson; Kaitlyn A Webster; Dror Weiss; Pier Paolo Pandolfi
In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma.
Cell 2011;147(2):382-95.
2011: Yvonne Tay; Dror Weiss; Ugo Ala; Ferdinando Di Cunto; Florian Karreth; Lev Kats; Judy Lieberman; Laura Poliseno; Paolo Provero; Isidore Rigoutsos; Leonardo Salmena; Shen Mynn Tan; Pier Paolo Pandolfi
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs.
Cell 2011;147(2):344-57.
2011: Alice H Berger; Alfred G Knudson; Pier Paolo Pandolfi
A continuum model for tumour suppression.
Nature 2011;476(7359):163-9.
2011: Leonardo Salmena; Yvonne Tay; Lev Kats; Laura Poliseno; Pier Paolo Pandolfi
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
Cell 2011;146(3):353-8.
2011: Caterina Nardella; Lewis C Cantley; Andrea Lunardi; Akash Patnaik; Pier Paolo Pandolfi
The APL paradigm and the "co-clinical trial" project.
Cancer discovery 2011;1(2):108-16.
2011: Caterina Nardella; George Thomas; Andrea Alimonti; John G Clohessy; Giuseppe Fedele; Sara C Kozma; Massimo Loda; Andrea Lunardi; Pier Paolo Pandolfi
Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis.
Cancer research 2011;71(10):3669-75.
2011: Rosa Bernardi; Antonella Papa; Ainara Egia; Nadia Coltella; Julie Teruya-Feldstein; Sabina Signoretti; Pier Paolo Pandolfi
Pml represses tumour progression through inhibition of mTOR.
EMBO molecular medicine 2011;3(5):249-57.
2011: Lydia W S Finley; Arkaitz Carracedo; Jaewon Lee; Amanda Souza; Ainara Egia; Jiangwen Zhang; Julie T Feldstein; Paula I Moreira; Sandra M Cardoso; Clary B Clish; Pier Paolo Pandolfi; Marcia C Haigis
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.
Cancer cell 2011;19(3):416-28.
2011: Pier Paolo Scaglioni; Nicholas D Socci; Thomas M Yung; Lu Fan Cai; Scott C Kogan; Levy Kopelovich; Samia M Majid; Pier Paolo Pandolfi
Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model.
Genes & cancer 2011;2(2):160-5.
2011: Min Sup Song; Arkaitz Carracedo; Leonardo Salmena; Su Jung Song; Ainara Egia; Marcos Malumbres; Pier Paolo Pandolfi
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
Cell 2011;144(2):187-99.
2011: Sergei Boichuk; Liang Hu; Kathleen Makielski; Pier Paolo Pandolfi; Ole V Gjoerup
Functional connection between Rad51 and PML in homology-directed repair.
PloS one 2011;6(10):e25814.
2011: Andrea Lunardi; Lucio Luzzatto; Pier Giuseppe Pelicci; R Rivi; Leonardo Salmena; Michael Antoniou; Marina Botto; Anne Bygrave; Carlos Cordon-Cardo; Dubravka Drabek; Elaine Dzierzak; Marta Fagioli; Mirella Gaboli; Marco Giorgio; Frank Grosveld; Pier Paolo Pandolfi
A Role for PML in Innate Immunity.
Genes & cancer 2011;2(1):10-9.
2011: Alice H Berger; Pier Paolo Pandolfi
Haplo-insufficiency: a driving force in cancer.
The Journal of pathology 2011;223(2):137-46.
2010: Laura M Snell; Ann J McPherson; Gloria H Y Lin; Shimon Sakaguchi; Pier Paolo Pandolfi; Carlo Riccardi; Tania H Watts
CD8 T cell-intrinsic GITR is required for T cell clonal expansion and mouse survival following severe influenza infection.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(12):7223-34.
2010: Robin M Hobbs; Seandel Marco; Ilaria Falciatori; Shahin Rafii; Pier Paolo Pandolfi
Plzf regulates germline progenitor self-renewal by opposing mTORC1.
Cell 2010;142(3):468-79.
2010: Laura Poliseno; Leonardo Salmena; Jiangwen Zhang; Brett S Carver; William J Haveman; Pier Paolo Pandolfi
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology.
Nature 2010;465(7301):1033-8.
2010: Robin M Hobbs; Pier Paolo Pandolfi
Shape-shifting and tumor suppression by PLZF.
Oncotarget 2010;1(1):3-5.
2010: Andrea Alimonti; Arkaitz Carracedo; John G Clohessy; Lloyd C Trotman; Caterina Nardella; Ainara Egia; Leonardo Salmena; Katia Sampieri; William J Haveman; Edi Brogi; Andrea L Richardson; Jiangwen Zhang; Pier Paolo Pandolfi
Subtle variations in Pten dose determine cancer susceptibility.
Nature genetics 2010;42(5):454-8.
2010: Chia-Hsin Chan; Szu-Wei Lee; Chien-Feng Li; Jing Wang; Wei-Lei Yang; Ching-Yuan Wu; Juan Wu; Keiichi I Nakayama; Hong-Yo Kang; Hsuan-Ying Huang; Mien-Chie Hung; Pier Paolo Pandolfi; Hui-Kuan Lin
Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis.
Nature cell biology 2010;12(5):457-67.
2010: Hui-Kuan Lin; Zhenbang Chen; Guocan Wang; Caterina Nardella; Szu-Wei Lee; Chia-Hsin Chan; Chan-Hsin Chan; Wei-Lei Yang; Jing Wang; Ainara Egia; Keiichi I Nakayama; Carlos Cordon-Cardo; Julie T Feldstein; Pier Paolo Pandolfi
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.
Nature 2010;464(7287):374-9.
2010: Andrea Alimonti; Caterina Nardella; Zhenbang Chen; John G Clohessy; Arkaitz Carracedo; Lloyd C Trotman; Ke Cheng; Shohreh Varmeh; Sara C Kozma; George Thomas; Erika Rosivatz; Rudiger Woscholski; Francesco Cognetti; Howard I Scher; Pier Paolo Pandolfi
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
The Journal of clinical investigation 2010;120(3):681-93.
2010: Alice H Berger; Masaru Niki; Alessandro Morotti; Barry S Taylor; Nicholas D Socci; Agnes Viale; Cameron Brennan; Janos Szoke; Noriko Motoi; Paul B Rothman; Julie T Feldstein; William L Gerald; Marc Ladanyi; Pier Paolo Pandolfi
Identification of DOK genes as lung tumor suppressors.
Nature genetics 2010;42(3):216-23.
2010: Eric S Alonzo; Rachel A Gottschalk; Joy Das; Takeshi Egawa; Robin M Hobbs; Pier Paolo Pandolfi; Pablo Pereira; Kim E Nichols; Gary A Koretzky; Martha S Jordan; Derek B Sant'Angelo
Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1268-79.
2010: Caterina Nardella; Arkaitz Carracedo; Leonardo Salmena; Pier Paolo Pandolfi
Faithfull modeling of PTEN loss driven diseases in the mouse.
Current topics in microbiology and immunology 2010;347():135-68.
2010: Laura Poliseno; Leonardo Salmena; Luisa Riccardi; Alessandro Fornari; Min Sup Song; Robin M Hobbs; Paolo Sportoletti; Shorheh Varmeh; Ainara Egia; Giuseppe Fedele; Lucia Rameh; Massimo Loda; Pier Paolo Pandolfi
Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.
Science signaling 2010;3(117):ra29.
2010: Enrico Mihich; Pier Paolo Pandolfi; David Livingston
Twenty-first annual Pezcoller Symposium: Unconventional Therapeutic Targets in Cancer.
Cancer research 2010;70(1):14-7.
2009: Takahiro Maeda; Keisuke Ito; Taha Merghoub; Laura Poliseno; Robin M Hobbs; Guocan Wang; Lin Dong; Manami Maeda; Lou Dore; Arthur Zelent; Lucio Luzzatto; Julie T Feldstein; Mitchell J Weiss; Pier Paolo Pandolfi
LRF is an essential downstream target of GATA1 in erythroid development and regulates BIM-dependent apoptosis.
Developmental cell 2009;17(4):527-40.
2009: Christina Gewinner; Zhigang C Wang; Andrea Richardson; Julie T Feldstein; Dariush Etemadmoghadam; David D L Bowtell; Jordi Barretina; William M Lin; Lucia Rameh; Leonardo Salmena; Pier Paolo Pandolfi; Lewis C Cantley
Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling.
Cancer cell 2009;16(2):115-25.
2009: Alejandro Gutierrez; Takaomi Sanda; Ruta Grebliunaite; Arkaitz Carracedo; Leonardo Salmena; Yebin Ahn; Suzanne Dahlberg; Donna Neuberg; Lisa A Moreau; Stuart S Winter; Richard Larson; Jianhua Zhang; Alexei Protopopov; Lynda Chin; Pier Paolo Pandolfi; Lewis B Silverman; Stephen P Hunger; Stephen E Sallan; A Thomas Look
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia.
Blood 2009;114(3):647-50.
2009: María Salazar; Arkaitz Carracedo; Iñigo J Salanueva; Sonia Hernández-Tiedra; Mar Lorente; Ainara Egia; Patricia Vázquez; Cristina Blázquez; Sofía Torres; Stephane García; Jonathan Nowak; Gian María Fimia; Mauro Piacentini; Francesco Cecconi; Pier Paolo Pandolfi; Luis González-Feria; Juan L Iovanna; Manuel Guzmán; Patricia Boya; Guillermo Velasco
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.
The Journal of clinical investigation 2009;119(5):1359-72.
2009: Brett S Carver; Jennifer Tran; Anuradha Gopalan; Zhenbang Chen; Safa Shaikh; Arkaitz Carracedo; Andrea Alimonti; Caterina Nardella; Shohreh Varmeh; Peter T Scardino; Carlos Cordon-Cardo; William Gerald; Pier Paolo Pandolfi
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
Nature genetics 2009;41(5):619-24.
2009: John G Clohessy; Pier Paolo Pandolfi
beta-tting on p63 as a metastatic suppressor.
Cell 2009;137(1):28-30.
2009: Hui-Kuan Lin; Guocan Wang; Zhenbang Chen; Julie T Feldstein; Yan Liu; Chia-Hsin Chan; Wei-Lei Yang; Hediye Erdjument-Bromage; Keiichi I Nakayama; Stephen D Nimer; Paul Tempst; Pier Paolo Pandolfi
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
Nature cell biology 2009;11(4):420-32.
2009: Brett S Carver; Jennifer Tran; Zhenbang Chen; Arkaitz Carracedo-Perez; Andrea Alimonti; Caterina Nardella; Anuradha Gopalan; Peter T Scardino; Carlos Cordon-Cardo; William Gerald; Pier Paolo Pandolfi
ETS rearrangements and prostate cancer initiation.
Nature 2009;457(7231):E1; discussion E2-3.
2009: Keisuke Ito; Rosa Bernardi; Pier Paolo Pandolfi
A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell.
Current opinion in genetics & development 2009;19(1):51-9.
2009: Li Li; Amalia Dutra; Evgenia Pak; Joseph E Labrie; Rachel M Gerstein; Pier Paolo Pandolfi; Larry D Recht; Alonzo H Ross
EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors.
Neuro-oncology 2009;11(1):9-21.
2009: Zhenbang Chen; Arkaitz Carracedo; Hui-Kuan Lin; Jason A Koutcher; Nille Behrendt; Ainara Egia; Andrea Alimonti; Brett S Carver; William Gerald; Julie T Feldstein; Massimo Loda; Pier Paolo Pandolfi
Differential p53-independent outcomes of p19(Arf) loss in oncogenesis.
Science signaling 2009;2(84):ra44.
2009: Caterina Nardella; Arkaitz Carracedo; Andrea Alimonti; Robin M Hobbs; John G Clohessy; Zhenbang Chen; Ainara Egia; Alessandro Fornari; Michelangelo Fiorentino; Massimo Loda; Sara C Kozma; George Thomas; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Differential requirement of mTOR in postmitotic tissues and tumorigenesis.
Science signaling 2009;2(55):ra2.
2008: Arkaitz Carracedo; Jose Baselga; Pier Paolo Pandolfi
Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors.
Cell cycle (Georgetown, Tex.) 2008;7(24):3805-9.
2008: NASR Rihab; Marie-Claude Guillemin; Omar Ferhi; Hassan Soilihi; Laurent Peres; Caroline Berthier; Philippe Rousselot; Macarena Robledo-Sarmiento; Valérie Lallemand-Breitenbach; Bernard Gourmel; Dominique VITOUX; Pier Paolo Pandolfi; Cécile Rochette-Egly; Jun Zhu; Hugues de Thé
Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.
Nature medicine 2008;14(12):1333-42.
2008: Leonard Bruno Maggi; Michael Kuchenruether; David Y A Dadey; Rachel M Schwope; Silvia Grisendi; R Reid Townsend; Pier Paolo Pandolfi; Jason D. Weber
Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.
Molecular and cellular biology 2008;28(23):7050-65.
2008: Yutaka Shima; Takito Shima; Tomoki Chiba; Tatsuro Irimura; Pier Paolo Pandolfi; Issay Kitabayashi
PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.
Molecular and cellular biology 2008;28(23):7126-38.
2008: R Bernardi; A Papa; Pier Paolo Pandolfi
Regulation of apoptosis by PML and the PML-NBs.
Oncogene 2008;27(48):6299-312.
2008: Min Sup Song; Leonardo Salmena; Arkaitz Carracedo; Ainara Egia; Francesco Lo Coco; Julie T Feldstein; Pier Paolo Pandolfi
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network.
Nature 2008;455(7214):813-7.
2008: Arkaitz Carracedo; Pier Paolo Pandolfi
The PTEN-PI3K pathway: of feedbacks and cross-talks.
Oncogene 2008;27(41):5527-41.
2008: Fumihiko Hayakawa; Akihiro Abe; Issay Kitabayashi; Pier Paolo Pandolfi; Tomoki Naoe
Acetylation of PML is involved in histone deacetylase inhibitor-mediated apoptosis.
The Journal of biological chemistry 2008;283(36):24420-5.
2008: Arkaitz Carracedo; Li Ma; Julie T Feldstein; Federico Rojo; Leonardo Salmena; Andrea Alimonti; Ainara Egia; Atsuo Sasaki; George Thomas; Sara C Kozma; Antonella Papa; Caterina Nardella; Lewis C Cantley; Jose Baselga; Pier Paolo Pandolfi
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer.
The Journal of clinical investigation 2008;118(9):3065-74.
2008: Damian Kovalovsky; Olisambu U. Uche; Sonia Eladad; Robin M Hobbs; Woelsung Yi; Eric Alonzo; Kevin Chua; Maggie Eidson; Hye-Jung Kim; Jin S Im; Pier Paolo Pandolfi; Derek B Sant'Angelo
The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.
Nature immunology 2008;9(9):1055-64.
2008: Caterina Nardella; Zhenbang Chen; Leonardo Salmena; Arkaitz Carracedo; Andrea Alimonti; Ainara Egia; Brett S Carver; William Gerald; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
Genes & development 2008;22(16):2172-7.
2008: Shuming Chen; Lishomwa C Ndhlovu; Takeshi Takahashi; Kazuyoshi Takeda; Yoshinori Ikarashi; Toshiaki Kikuchi; Kazuko Murata; Pier Paolo Pandolfi; Carlo Riccardi; Masao Ono; Kazuo Sugamura; Naoto Ishii
Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells.
European journal of immunology 2008;38(8):2229-40.
2008: Keisuke Ito; Rosa Bernardi; Alessandro Morotti; Sahoko Matsuoka; Giuseppe Saglio; Yasuo Ikeda; Jacalyn Rosenblatt; David E Avigan; Julie T Feldstein; Pier Paolo Pandolfi
PML targeting eradicates quiescent leukaemia-initiating cells.
Nature 2008;453(7198):1072-8.
2008: Jose A.. Costoya; Robin M Hobbs; Pier Paolo Pandolfi
Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation.
Oncogene 2008;27(27):3789-96.
2008: Arkaitz Carracedo; Leonardo Salmena; Pier Paolo Pandolfi
SnapShot: PTEN signaling pathways.
Cell 2008;133(3):550.e1.
2008: Leonardo Salmena; Arkaitz Carracedo; Pier Paolo Pandolfi
Tenets of PTEN tumor suppression.
Cell 2008;133(3):403-14.
2008: Paolo Sportoletti; Silvia Grisendi; Samia M Majid; Ke Cheng; John G Clohessy; Agnes Viale; Julie T Feldstein; Pier Paolo Pandolfi
Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.
Blood 2008;111(7):3859-62.
2008: Dolares Hambardzumyan; Oren Josh Becher; Marc K Rosenblum; Pier Paolo Pandolfi; Katia Manova-Todorova; Eric C Holland
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.
Genes & development 2008;22(4):436-48.
2008: Virginia Klimek; Sophia Fircanis; Peter Maslak; Ilhem Guernah; Michael Baum; Nian Wu; Katherine S Panageas; John J Wright; Pier Paolo Pandolfi; Stephen D Nimer
Tolerability, pharmacodynamics, and pharmacokinetics studies of depsipeptide (romidepsin) in patients with acute myelogenous leukemia or advanced myelodysplastic syndromes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):826-32.
2008: Gerard W O'Keeffe; Humberto Gutierrez; Pier Paolo Pandolfi; Carlo Riccardi; Alun M Davies
NGF-promoted axon growth and target innervation requires GITRL-GITR signaling.
Nature neuroscience 2008;11(2):135-42.
2008: Michelle L Janas; Daniel Hodson; Zania Stamataki; Sue Hill; Katie Welch; Laure Gambardella; Lloyd C Trotman; Pier Paolo Pandolfi; Elena Vigorito; Martin Turner
The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):739-46.
2008: Laura Poliseno; Letizia Pitto; Marcella Simili; Laura Mariani; Luisa Riccardi; Alessia Ciucci; Milena Rizzo; Monica Evangelista; Alberto Mercatanti; Pier Paolo Pandolfi; Giuseppe Rainaldi
The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence.
PloS one 2008;3(7):e2542.
2007: Rosa Bernardi; Pier Paolo Pandolfi
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies.
Nature reviews. Molecular cell biology 2007;8(12):1006-16.
2007: K Cheng; Silvia Grisendi; J G Clohessy; S Majid; Rosa Bernardi; P Sportoletti; Pier Paolo Pandolfi
The leukemia-associated cytoplasmic nucleophosmin mutant is an oncogene with paradoxical functions: Arf inactivation and induction of cellular senescence.
Oncogene 2007;26(53):7391-400.
2007: Fabien Guidez; Sarah Parks; Henna Wong; Jelena V Jovanovic; Ashley Mays; Amanda F Gilkes; Ken Mills; Marie-Claude Guillemin; Robin M Hobbs; Pier Paolo Pandolfi; Hugues de Thé; Ellen Solomon; David Grimwade
RARalpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t(11;17) acute promyelocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18694-9.
2007: Doria Filipponi; Robin M Hobbs; Sergio Ottolenghi; Pellegrino Rossi; Emmanuele Jannini; Pier Paolo Pandolfi; Susanna Dolci
Repression of kit expression by Plzf in germ cells.
Molecular and cellular biology 2007;27(19):6770-81.
2007: Seandel Marco; Daylon James; Sergey V Shmelkov; Ilaria Falciatori; Jiyeon Kim; Sai Chavala; Douglas Scherr; Fan Zhang; Richard Torres; nicholas gale; George D Yancopoulos; Andrew Murphy; David M Valenzuela; Robin M Hobbs; Pier Paolo Pandolfi; Shahin Rafii
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.
Nature 2007;449(7160):346-50.
2007: Brian P Hermann; Meena Sukhwani; Chih-Cheng Lin; Yi Sheng; Jamie Tomko; Mario Rodriguez; Jennifer J Shuttleworth; David McFarland; Robin M Hobbs; Pier Paolo Pandolfi; Gerald Schatten; Kyle E Orwig
Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques.
Stem cells (Dayton, Ohio) 2007;25(9):2330-8.
2007: Li Ma; Julie T Feldstein; Pauline Bonner; Rosa Bernardi; David Neal Franz; David Witte; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.
Cancer research 2007;67(15):7106-12.
2007: Hitoshi Yoshida; Hitoshi Ichikawa; Yusuke Tagata; Takuo Katsumoto; Kazunori Ohnishi; Yukihiro Akao; Tomoki Naoe; Pier Paolo Pandolfi; Issay Kitabayashi
PML-retinoic acid receptor alpha inhibits PML IV enhancement of PU.1-induced C/EBPepsilon expression in myeloid differentiation.
Molecular and cellular biology 2007;27(16):5819-34.
2007: Leonardo Salmena; Pier Paolo Pandolfi
Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation.
Nature reviews. Cancer 2007;7(6):409-13.
2007: Eva Hernando; Elizabeth Charytonowicz; Maria E Dudas; Silvia Menendez; Igor Matushansky; Joslyn Mills; Nicholas D Socci; Nille Behrendt; Li Ma; ROBERT G MAKI; Pier Paolo Pandolfi; Carlos Cordon-Cardo
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas.
Nature medicine 2007;13(6):748-53.
2007: Takahiro Maeda; Taha Merghoub; Robin M Hobbs; Lin Dong; Manami Maeda; Johannes L Zakrzewski; Marcel R M van den Brink; Arthur Zelent; Hirokazu Shigematsu; Koichi Akashi; Julie T Feldstein; Giorgio Cattoretti; Pier Paolo Pandolfi
Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.
Science (New York, N.Y.) 2007;316(5826):860-6.
2007: Wen Hong Shen; Adayabalam S Balajee; Jianli Wang; Hong Wu; Charis Eng; Pier Paolo Pandolfi; Yuxin Yin
Essential role for nuclear PTEN in maintaining chromosomal integrity.
Cell 2007;128(1):157-70.
2007: Lloyd C Trotman; Xinjiang Wang; Andrea Alimonti; Zhenbang Chen; Julie T Feldstein; Haijuan Yang; Nikola P Pavletich; Brett S Carver; Carlos Cordon-Cardo; Hediye Erdjument-Bromage; Paul Tempst; Sung-Gil Chi; Hyo Jong Kim; Tom Misteli; Xuejun Jiang; Pier Paolo Pandolfi
Ubiquitination regulates PTEN nuclear import and tumor suppression.
Cell 2007;128(1):141-56.
2007: Xinjiang Wang; Lloyd C Trotman; Theresa Koppie; Andrea Alimonti; Zhenbang Chen; Zhonghua Gao; Junru Wang; Hediye Erdjument-Bromage; Paul Tempst; Carlos Cordon-Cardo; Pier Paolo Pandolfi; Xuejun Jiang
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
Cell 2007;128(1):129-39.
2007: Pier Paolo Scaglioni; Pier Paolo Pandolfi
The theory of APL revisited.
Current topics in microbiology and immunology 2007;313():85-100.
2007: Pier Paolo Pandolfi
APL as a paradigm in biomedical research: a journey toward the cure.
Current topics in microbiology and immunology 2007;313():1-2.
2006: Jan H Schefe; Mario Menk; Jana Reinemund; Karin Effertz; Robin M Hobbs; Pier Paolo Pandolfi; Patricia Ruiz; Thomas Unger; Heiko Funke-Kaiser
A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein.
Circulation research 2006;99(12):1355-66.
2006: Youn-Hee Choi; Rosa Bernardi; Pier Paolo Pandolfi; Etty N Benveniste
The promyelocytic leukemia protein functions as a negative regulator of IFN-gamma signaling.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(49):18715-20.
2006: Tian Huai Shen; Hui-Kuan Lin; Pier Paolo Scaglioni; Thomas M Yung; Pier Paolo Pandolfi
The mechanisms of PML-nuclear body formation.
Molecular cell 2006;24(3):331-9.
2006: Stephan Bergmann; Pier Paolo Pandolfi
Giving blood: a new role for CD40 in tumorigenesis.
The Journal of experimental medicine 2006;203(11):2409-12.
2006: Yeonsoo Joe; Jae-Hoon Jeong; Shutong Yang; Hyeog Kang; Noburu Motoyama; Pier Paolo Pandolfi; Jay H Chung; Myung K Kim
ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis.
The Journal of biological chemistry 2006;281(39):28764-71.
2006: Shutong Yang; Jae-Hoon Jeong; Alexandra L Brown; Chang-Hun Lee; Pier Paolo Pandolfi; Jay H Chung; Myung K Kim
Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.
The Journal of biological chemistry 2006;281(36):26645-54.
2006: Rosa Bernardi; Ilhem Guernah; David Jin; Silvia Grisendi; Andrea Alimonti; Julie T Feldstein; Carlos Cordon-Cardo; M Celeste Simon; Shahin Rafii; Pier Paolo Pandolfi
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.
Nature 2006;442(7104):779-85.
2006: Pier Paolo Scaglioni; Thomas M Yung; Lu Fan Cai; Hediye Erdjument-Bromage; Andrew J Kaufman; Bhuvanesh Singh; Julie T Feldstein; Paul Tempst; Pier Paolo Pandolfi
A CK2-dependent mechanism for degradation of the PML tumor suppressor.
Cell 2006;126(2):269-83.
2006: Silvia Grisendi; Cristina Mecucci; Brunangelo Falini; Pier Paolo Pandolfi
Nucleophosmin and cancer.
Nature reviews. Cancer 2006;6(7):493-505.
2006: Mei-Ling Chen; Pei-Zhang Xu; Xiao-ding Peng; William S Chen; Grace Guzman-Hartman; Ximing Yang; Antonio Di Cristofano; Pier Paolo Pandolfi; Nissim Hay
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice.
Genes & development 2006;20(12):1569-74.
2006: Feng Bai; Zhijun Li; Pier Paolo Pandolfi; Yue Xiong
p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control.
Molecular and cellular biology 2006;26(12):4564-76.
2006: Lloyd C Trotman; Andrea Alimonti; Pier Paolo Scaglioni; Jason A Koutcher; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Identification of a tumour suppressor network opposing nuclear Akt function.
Nature 2006;441(7092):523-7.
2006: Hiromichi Matsushita; Pier Paolo Scaglioni; Mantu Bhaumik; Eduardo M Rego; Lu Fan Cai; Samia M Majid; Hayato Miyachi; Akira Kakizuka; Wilson H Miller; Pier Paolo Pandolfi
In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.
The Journal of experimental medicine 2006;203(4):821-8.
2006: Masaki Kashiwada; Giorgio Cattoretti; Lisa McKeag; Todd Rouse; Brian M Showalter; Umaima Al-Alem; Masaru Niki; Pier Paolo Pandolfi; Elizabeth H Field; Paul B Rothman
Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):3958-65.
2006: Mingming Zhao; Justyna A Janas; Masaru Niki; Pier Paolo Pandolfi; Linda Van Aelst
Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.
Molecular and cellular biology 2006;26(7):2479-89.
2006: Eduardo M Rego; Davide Ruggero; C Tribioli; Giorgio Cattoretti; S Kogan; R L Redner; Pier Paolo Pandolfi
Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha.
Oncogene 2006;25(13):1974-9.
2006: Peter Maslak; Suzanne M Chanel; Luis H Camacho; Steven L Soignet; Pier Paolo Pandolfi; I Guernah; RP Warrell; Stephen D Nimer
Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome.
Leukemia 2006;20(2):212-7.
2006: Elena Savoia; Maria Pia Fantini; Pier Paolo Pandolfi; Laura Dallolio; Natalina Collina
Assessing the construct validity of the Italian version of the EQ-5D: preliminary results from a cross-sectional study in North Italy.
Health and quality of life outcomes 2006;4():47.
2006: Vicente Andrés; Marisol Gascón-Irún; Pier Paolo Pandolfi; Herminia González-Navarro
Atheroma development in apolipoprotein E-null mice is not affected by partial inactivation of PTEN.
Frontiers in bioscience : a journal and virtual library 2006;11():2739-45.
2006: David R Shaffer; Pier Paolo Pandolfi
Breaking the rules of cancer.
Nature medicine 2006;12(1):14-5.
2005: Karim Nacerddine; François Lehembre; Mantu Bhaumik; ARTUS Jerome; Michel Cohen-Tannoudji; Charles Babinet; Pier Paolo Pandolfi; Anne Dejean
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.
Developmental cell 2005;9(6):769-79.
2005: Jian Wang; Vikram Devgan; Marcella Corrado; Nita S Prabhu; Wafik S El-Deiry; Carlo Riccardi; Pier Paolo Pandolfi; Caterina Missero; G Paolo Dotto
Glucocorticoid-induced tumor necrosis factor receptor is a p21Cip1/WAF1 transcriptional target conferring resistance of keratinocytes to UV light-induced apoptosis.
The Journal of biological chemistry 2005;280(45):37725-31.
2005: Francesca Bernassola; Andrew Oberst; Gerry Melino; Pier Paolo Pandolfi
The promyelocytic leukaemia protein tumour suppressor functions as a transcriptional regulator of p63.
Oncogene 2005;24(46):6982-6.
2005: Takahiro Maeda; Robin M Hobbs; Pier Paolo Pandolfi
The transcription factor Pokemon: a new key player in cancer pathogenesis.
Cancer research 2005;65(19):8575-8.
2005: Silvia Grisendi; Rosa Bernardi; Marco Rossi; Ke Cheng; Luipa Khandker; Katia Manova-Todorova; Pier Paolo Pandolfi
Role of nucleophosmin in embryonic development and tumorigenesis.
Nature 2005;437(7055):147-53.
2005: Hui-Kuan Lin; Stephan Bergmann; Pier Paolo Pandolfi
Deregulated TGF-beta signaling in leukemogenesis.
Oncogene 2005;24(37):5693-700.
2005: Zhenbang Chen; Lloyd C Trotman; David Shaffer; Hui-Kuan Lin; Zohar A Dotan; Masaru Niki; Jason A Koutcher; Howard I Scher; Thomas Ludwig; William Gerald; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis.
Nature 2005;436(7051):725-30.
2005: Li Ma; Julie T Feldstein; Nille Behrendt; Zhenbang Chen; Tetsuo Noda; Okio Hino; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression.
Genes & development 2005;19(15):1779-86.
2005: Maria Barna; Pier Paolo Pandolfi; Lee Niswander
Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development.
Nature 2005;436(7048):277-81.
2005: Andrew Xiao; Chaoying Yin; Chunyu Yang; Antonio Di Cristofano; Pier Paolo Pandolfi; Terry Van Dyke
Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation.
Cancer research 2005;65(12):5172-80.
2005: Andrew Oberst; Mario Rossi; Paolo Salomoni; Pier Paolo Pandolfi; Moshe Oren; Gerry Melino; Francesca Bernassola
Regulation of the p73 protein stability and degradation.
Biochemical and biophysical research communications 2005;331(3):707-12.
2005: Paolo Salomoni; Rosa Bernardi; Stephan Bergmann; Austin Changou; Sara Tuttle; Pier Paolo Pandolfi
The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage.
Blood 2005;105(9):3686-90.
2005: Li Ma; Zhenbang Chen; Hediye Erdjument-Bromage; Paul Tempst; Pier Paolo Pandolfi
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis.
Cell 2005;121(2):179-93.
2005: Xiaoyi Hu; Pier Paolo Pandolfi; Yi Li; Jason A Koutcher; Marc K Rosenblum; Eric C Holland
mTOR promotes survival and astrocytic characteristics induced by Pten/AKT signaling in glioblastoma.
Neoplasia (New York, N.Y.) 2005;7(4):356-68.
2005: Stefano Cairo; Francesca De Falco; Mariateresa Pizzo; Paolo Salomoni; Pier Paolo Pandolfi; Germana Meroni
PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
Oncogene 2005;24(13):2195-203.
2005: Shinji Oki; André Limnander; Pin Mei Yao; Masaru Niki; Pier Paolo Pandolfi; Paul B Rothman
Dok1 and SHIP act as negative regulators of v-Abl-induced pre-B cell transformation, proliferation and Ras/Erk activation.
Cell cycle (Georgetown, Tex.) 2005;4(2):310-4.
2005: Takahiro Maeda; Robin M Hobbs; Taha Merghoub; Ilhem Guernah; Arthur Zelent; Carlos Cordon-Cardo; Julie T Feldstein; Pier Paolo Pandolfi
Role of the proto-oncogene Pokemon in cellular transformation and ARF repression.
Nature 2005;433(7023):278-85.
2005: Silvia Grisendi; Pier Paolo Pandolfi
NPM mutations in acute myelogenous leukemia.
The New England journal of medicine 2005;352(3):291-2.
2005: Seiichi Okabe; Seiji Fukuda; Young-June Kim; Masaru Niki; Louis M Pelus; Kazuma Ohyashiki; Pier Paolo Pandolfi; Hal E Broxmeyer
Stromal cell-derived factor-1alpha/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1.
Blood 2005;105(2):474-80.
2005: Silvia Grisendi; Pier Paolo Pandolfi
Two decades of cancer genetics: from specificity to pleiotropic networks.
Cold Spring Harbor symposia on quantitative biology 2005;70():83-91.
2005: Lan Anh Nguyen; Pier Paolo Pandolfi; Yukiko Aikawa; Yusuke Tagata; Misao Ohki; Issay Kitabayashi
Physical and functional link of the leukemia-associated factors AML1 and PML.
Blood 2005;105(1):292-300.
2004: Masaru Niki; Antonio Di Cristofano; Mingming Zhao; Hiroaki Honda; Hisamaru Hirai; Linda Van Aelst; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Role of Dok-1 and Dok-2 in leukemia suppression.
The Journal of experimental medicine 2004;200(12):1689-95.
2004: Francesco Piazza; Jose A.. Costoya; Taha Merghoub; Robin M Hobbs; Pier Paolo Pandolfi
Disruption of PLZP in mice leads to increased T-lymphocyte proliferation, cytokine production, and altered hematopoietic stem cell homeostasis.
Molecular and cellular biology 2004;24(23):10456-69.
2004: Pier Paolo Pandolfi
Breast cancer--loss of PTEN predicts resistance to treatment.
The New England journal of medicine 2004;351(22):2337-8.
2004: Lorenzo Montanaro; Pier Paolo Pandolfi
Initiation of mRNA translation in oncogenesis: the role of eIF4E.
Cell cycle (Georgetown, Tex.) 2004;3(11):1387-9.
2004: Hui-Kuan Lin; Stephan Bergmann; Pier Paolo Pandolfi
Cytoplasmic PML function in TGF-beta signalling.
Nature 2004;431(7005):205-11.
2004: Othmar G Engelhardt; Hüseyin Sirma; Pier Paolo Pandolfi; Otto Haller
Mx1 GTPase accumulates in distinct nuclear domains and inhibits influenza A virus in cells that lack promyelocytic leukaemia protein nuclear bodies.
The Journal of general virology 2004;85(Pt 8):2315-26.
2004: Anna L M Ferri; Maurizio Cavallaro; Daniela Braida; Antonio Di Cristofano; Annalisa Canta; Annamaria Vezzani; Sergio Ottolenghi; Pier Paolo Pandolfi; Mariaelvina Sala; Silvia DeBiasi; Silvia K Nicolis
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.
Development (Cambridge, England) 2004;131(15):3805-19.
2004: Stephanie J Muriglan; Teresa Ramirez-Montagut; Onder Alpdogan; Thomas W Van Huystee; Jeffrey M Eng; Vanessa M Hubbard; Adam A Kochman; Kartono H Tjoe; Carlo Riccardi; Pier Paolo Pandolfi; Shimon Sakaguchi; Alan N Houghton; Marcel R M van den Brink
GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease.
The Journal of experimental medicine 2004;200(2):149-57.
2004: Rosa Bernardi; Pier Paolo Scaglioni; Stephan Bergmann; Henning F Horn; Karen H Vousden; Pier Paolo Pandolfi
PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
Nature cell biology 2004;6(7):665-72.
2004: Francesca Bernassola; Paolo Salomoni; Andrew Oberst; Charles J DiComo; Michele Pagano; Gerry Melino; Pier Paolo Pandolfi
Ubiquitin-dependent degradation of p73 is inhibited by PML.
The Journal of experimental medicine 2004;199(11):1545-57.
2004: Jose A.. Costoya; Robin M Hobbs; Maria Barna; Giorgio Cattoretti; Katia Manova-Todorova; Meena Sukhwani; Kyle E Orwig; Debra J Wolgemuth; Pier Paolo Pandolfi
Essential role of Plzf in maintenance of spermatogonial stem cells.
Nature genetics 2004;36(6):653-9.
2004: Pamela J Woodring; Jill Meisenhelder; Sam A Johnson; Guo-Lei Zhou; Jeffrey Field; Kavita Shah; Friedhelm Bladt; Tony Pawson; Masaru Niki; Pier Paolo Pandolfi; Jean Y J Wang; Tony Hunter
c-Abl phosphorylates Dok1 to promote filopodia during cell spreading.
The Journal of cell biology 2004;165(4):493-503.
2004: Davide Ruggero; Lorenzo Montanaro; Li Ma; Wei Xu; Paola Londei; Carlos Cordon-Cardo; Pier Paolo Pandolfi
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.
Nature medicine 2004;10(5):484-6.
2004: Eric C Holland; Nahum Sonenberg; Pier Paolo Pandolfi; George Thomas
Signaling control of mRNA translation in cancer pathogenesis.
Oncogene 2004;23(18):3138-44.
2004: Pier Paolo Pandolfi
Aberrant mRNA translation in cancer pathogenesis: an old concept revisited comes finally of age.
Oncogene 2004;23(18):3134-7.
2004: Joan S Steffan; Namita Agrawal; Judit Pallos; Erica Rockabrand; Lloyd C Trotman; Natalia Slepko; Katalin Illes; Tamas Lukacsovich; Ya-Zhen Zhu; Elena Cattaneo; Pier Paolo Pandolfi; Leslie Michels Thompson; J Lawrence Marsh
SUMO modification of Huntingtin and Huntington's disease pathology.
Science (New York, N.Y.) 2004;304(5667):100-4.
2004: Carmela Gurrieri; Khedoudja Nafa; Taha Merghoub; Rosa Bernardi; Paola Capodieci; Andrea Biondi; Stephen D Nimer; Dan Douer; Carlos Cordon-Cardo; Robert E Gallagher; Pier Paolo Pandolfi
Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia.
Blood 2004;103(6):2358-62.
2004: Enza Piccolo; Sara Vignati; Tania Maffucci; Pasquale F Innominato; Andrew M Riley; Barry V L Potter; Pier Paolo Pandolfi; Massimo Broggini; Stefano Iacobelli; Paolo Innocenti; Marco Falasca
Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway.
Oncogene 2004;23(9):1754-65.
2004: Elisa de Stanchina; Emmanuelle Querido; Masako Narita; Ramana V Davuluri; Pier Paolo Pandolfi; Gerardo Ferbeyre; Scott W Lowe
PML is a direct p53 target that modulates p53 effector functions.
Molecular cell 2004;13(4):523-35.
2004: Carmela Gurrieri; Paola Capodieci; Rosa Bernardi; Pier Paolo Scaglioni; Khedoudja Nafa; Laura J Rush; David Verbel; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Loss of the tumor suppressor PML in human cancers of multiple histologic origins.
Journal of the National Cancer Institute 2004;96(4):269-79.
2004: Mahadeo A Sukhai; Xuemei Wu; Yali Xuan; Tong Zhang; Patricia P Reis; Karina Dubé; Eduardo M Rego; Mantu Bhaumik; Denis J Bailey; Richard A Wells; Suzanne Kamel-Reid; Pier Paolo Pandolfi
Myeloid leukemia with promyelocytic features in transgenic mice expressing hCG-NuMA-RARalpha.
Oncogene 2004;23(3):665-78.
2004: Zhi-Xiang Xu; Rui-Xun Zhao; Tian Ding; Thanh T Tran; Wei Zhang; Pier Paolo Pandolfi; Kun-Sang Chang
Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression.
The Journal of biological chemistry 2004;279(3):1838-44.
2003: Rosa Bernardi; Pier Paolo Pandolfi
Role of PML and the PML-nuclear body in the control of programmed cell death.
Oncogene 2003;22(56):9048-57.
2003: Pier Paolo Scaglioni; Pier Paolo Pandolfi
Medicine: taking apart a cancer protein.
Nature 2003;426(6966):512-3.
2003: Lloyd C Trotman; Masaru Niki; Zohar A Dotan; Jason A Koutcher; Antonio Di Cristofano; Andrew Xiao; Alan S Khoo; Pradip Roy-Burman; Norman M Greenberg; Terry Van Dyke; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Pten dose dictates cancer progression in the prostate.
PLoS biology 2003;1(3):E59.
2003: Marianna B Ruzinova; Rebecca A Schoer; William Gerald; James Egan; Pier Paolo Pandolfi; Shahin Rafii; Katia Manova-Todorova; Vivek Mittal; Robert Benezra
Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors.
Cancer cell 2003;4(4):277-89.
2003: Igal Louria-Hayon; Tamar Grossman; Ronit Sionov; Osnat Alsheich; Pier Paolo Pandolfi; Ygal Haupt
The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation.
The Journal of biological chemistry 2003;278(35):33134-41.
2003: Gerd H Moe-Behrens; Pier Paolo Pandolfi
Targeting aberrant transcriptional repression in acute myeloid leukemia.
Reviews in clinical and experimental hematology 2003;7(2):139-59.
2003: Ana Virginia Chee; Pascal LOPEZ; Pier Paolo Pandolfi; Bernard Roizman
Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects.
Journal of virology 2003;77(12):7101-5.
2003: Wen-Shu Wu; Zhi-Xiang Xu; Walter N Hittelman; Paolo Salomoni; Pier Paolo Pandolfi; Kun-Sang Chang
Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway.
The Journal of biological chemistry 2003;278(14):12294-304.
2003: Yasuo Ariumi; Takeshi Ego; Atsushi Kaida; Mikiko Matsumoto; Pier Paolo Pandolfi; Kunitada Shimotohno
Distinct nuclear body components, PML and SMRT, regulate the trans-acting function of HTLV-1 Tax oncoprotein.
Oncogene 2003;22(11):1611-9.
2003: Davide Ruggero; Pier Paolo Pandolfi
Does the ribosome translate cancer?
Nature reviews. Cancer 2003;3(3):179-92.
2003: Lionel Berthoux; Greg J Towers; Cagan Gurer; Paolo Salomoni; Pier Paolo Pandolfi; Jeremy Luban
As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity.
Journal of virology 2003;77(5):3167-80.
2003: Lloyd C Trotman; Pier Paolo Pandolfi
PTEN and p53: who will get the upper hand?
Cancer cell 2003;3(2):97-9.
2003: Carmen Carneiro; Maria Socorro Jiao; Ming Hu; David Shaffer; Michele Park; Pier Paolo Pandolfi; Carlos Cordon-Cardo; Andrew Koff
p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development.
Oncogene 2003;22(3):361-9.
2003: Davide Ruggero; Silvia Grisendi; Francesco Piazza; Eduardo M Rego; Francesca Mari; Pulivarthi H Rao; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Dyskeratosis congenita and cancer in mice deficient in ribosomal RNA modification.
Science (New York, N.Y.) 2003;299(5604):259-62.
2003: Rosa Bernardi; Pier Paolo Pandolfi
The nucleolus: at the stem of immortality.
Nature medicine 2003;9(1):24-5.
2002: Danielle Blondel; Tarik Regad; Nicolas Poisson; Benjamen Pavie; Francis Harper; Pier Paolo Pandolfi; Hugues de Thé; Mounira K Chelbi-Alix
Rabies virus P and small P products interact directly with PML and reorganize PML nuclear bodies.
Oncogene 2002;21(52):7957-70.
2002: Eugene S Kandel; Jennifer E Skeen; Nathan Majewski; Antonio Di Cristofano; Pier Paolo Pandolfi; Claudine S Feliciano; Andrei L Gartel; Nissim Hay
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.
Molecular and cellular biology 2002;22(22):7831-41.
2002: Sobha Kurian; Thomas F Hogan; Ona C Bleigh; Yvonne G Dowdy; Taha Merghoub; Pier Paolo Pandolfi; Sharon L Wenger
Atypical t(15;17)(q13;q12) in a patient with all-trans retinoic acid refractory secondary acute promyelocytic leukemia: a case report and review of the literature.
Cancer genetics and cytogenetics 2002;138(2):143-8.
2002: Jennifer L Best; Soula Ganiatsas; Sadhana Agarwal; Austin Changou; Paolo Salomoni; orian shirihai; Pamela B Meluh; Pier Paolo Pandolfi; Leonard I Zon
SUMO-1 protease-1 regulates gene transcription through PML.
Molecular cell 2002;10(4):843-55.
2002: Maria Barna; Taha Merghoub; Jose A.. Costoya; Davide Ruggero; Matthew Branford; Anna Bergia; Bruno Samori; Pier Paolo Pandolfi
Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling.
Developmental cell 2002;3(4):499-510.
2002: H Daniel Lacorazza; Yasushi Miyazaki; Antonio Di Cristofano; Anthony Deblasio; Cyrus V Hedvat; Jin Zhang; Carlos Cordon-Cardo; Shifeng Mao; Pier Paolo Pandolfi; Stephen D Nimer
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells.
Immunity 2002;17(4):437-49.
2002: Sunghoon Kim; Claire Domon-Dell; Qingding Wang; Dai H Chung; Antonio Di Cristofano; Pier Paolo Pandolfi; Jean-Noel Freund; B Mark Evers
PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.
Gastroenterology 2002;123(4):1163-78.
2002: Letizia Longo; Olga Camacho Vanegas; Meghavi Patel; Vittorio Rosti; Haiqing Li; John Waka; Taha Merghoub; Pier Paolo Pandolfi; Rosario Notaro; Katia Manova-Todorova; Lucio Luzzatto
Maternally transmitted severe glucose 6-phosphate dehydrogenase deficiency is an embryonic lethal.
The EMBO journal 2002;21(16):4229-39.
2002: Eduardo M Rego; Pier Paolo Pandolfi
Reciprocal products of chromosomal translocations in human cancer pathogenesis: key players or innocent bystanders?
Trends in molecular medicine 2002;8(8):396-405.
2002: Zeshaan A Rasheed; Ahamed Saleem; Yaniv Ravee; Pier Paolo Pandolfi; Eric H Rubin
The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies.
Experimental cell research 2002;277(2):152-60.
2002: Fyodor D Urnov; Edward J Rebar; Andreas Reik; Pier Paolo Pandolfi
Designed transcription factors as structural, functional and therapeutic probes of chromatin in vivo. Fourth in review series on chromatin dynamics.
EMBO reports 2002;3(7):610-5.
2002: Bryan Linggi; Carsten Müller-Tidow; Louis van de Locht; Ming Hu; John Nip; Hubert Serve; Wolfgang E Berdel; Bert A van der Reijden; Dawn E Quelle; Janet D Rowley; John Cleveland; Joop H Jansen; Pier Paolo Pandolfi; Scott W Hiebert
The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.
Nature medicine 2002;8(7):743-50.
2002: Simona Ronchetti; Giuseppe Nocentini; Carlo Riccardi; Pier Paolo Pandolfi
Role of GITR in activation response of T lymphocytes.
Blood 2002;100(1):350-2.
2002: Scott C Kogan; Jerrold M Ward; Miriam R Anver; Jules J Berman; CORY BRAYTON; Robert Cardiff; John S Carter; Sherri de Coronado; James R Downing; Torgny N Fredrickson; Diana C Haines; Alan W Harris; Nancy Lee Harris; Hiroshi Hiai; Elaine S Jaffe; Ian C M MacLennan; Pier Paolo Pandolfi; Paul K Pattengale; Archibald S Perkins; R Mark Simpson; Mark S Tuttle; Joanne F Wong; Herbert C Morse
Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice.
Blood 2002;100(1):238-45.
2002: Michael Morgan; Jacqueline Thorburn; Pier Paolo Pandolfi; Andrew Thorburn
Nuclear and cytoplasmic shuttling of TRADD induces apoptosis via different mechanisms.
The Journal of cell biology 2002;157(6):975-84.
2002: Paolo Salomoni; Pier Paolo Pandolfi
p53 De-ubiquitination: at the edge between life and death.
Nature cell biology 2002;4(6):E152-3.
2002: Rosa Bernardi; Silvia Grisendi; Pier Paolo Pandolfi
Modelling haematopoietic malignancies in the mouse and therapeutical implications.
Oncogene 2002;21(21):3445-58.
2002: Li Li; Fenghua Liu; Rebecca A Salmonsen; Tod K Turner; N Scott Litofsky; Antonio Di Cristofano; Pier Paolo Pandolfi; Stephen N Jones; Lawrence D Recht; Alonzo H Ross
PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
Molecular and cellular neurosciences 2002;20(1):21-9.
2002: Vanessa L Ott; Idan Tamir; Masaru Niki; Pier Paolo Pandolfi; John C Cambier
Downstream of kinase, p62(dok), is a mediator of Fc gamma IIB inhibition of Fc epsilon RI signaling.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4430-9.
2002: Andrew Xiao; Hua Wu; Pier Paolo Pandolfi; David N Louis; Terry Van Dyke
Astrocyte inactivation of the pRb pathway predisposes mice to malignant astrocytoma development that is accelerated by PTEN mutation.
Cancer cell 2002;1(2):157-68.
2002: Paolo Salomoni; Pier Paolo Pandolfi
The role of PML in tumor suppression.
Cell 2002;108(2):165-70.
2001: J O Ward; Melanie J McConnell; Graeme Carlile; Pier Paolo Pandolfi; Jonathan D Licht; Leonard P Freedman
The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor.
Blood 2001;98(12):3290-300.
2001: LZ He; Tolentino Thomas; P Grayson; S Zhong; RP Warrell; Richard A Rifkind; Paul A Marks; Victoria M Richon; Pier Paolo Pandolfi
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia.
The Journal of clinical investigation 2001;108(9):1321-30.
2001: Francesco Piazza; Carmela Gurrieri; Pier Paolo Pandolfi
The theory of APL.
Oncogene 2001;20(49):7216-22.
2001: Pier Paolo Pandolfi
In vivo analysis of the molecular genetics of acute promyelocytic leukemia.
Oncogene 2001;20(40):5726-35.
2001: P Keller; J L Payne; G Tremml; P A Greer; M Gaboli; Pier Paolo Pandolfi; Monica Bessler
FES-Cre targets phosphatidylinositol glycan class A (PIGA) inactivation to hematopoietic stem cells in the bone marrow.
The Journal of experimental medicine 2001;194(5):581-9.
2001: Antonio Di Cristofano; Masaru Niki; Mingming Zhao; Fredrick G Karnell; Bayard Clarkson; Warren S Pear; Linda Van Aelst; Pier Paolo Pandolfi
p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl).
The Journal of experimental medicine 2001;194(3):275-84.
2001: Mingming Zhao; A A Schmitz; Y Qin; Antonio Di Cristofano; Pier Paolo Pandolfi; Linda Van Aelst
Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation.
The Journal of experimental medicine 2001;194(3):265-74.
2001: Pier Paolo Pandolfi
Histone deacetylases and transcriptional therapy with their inhibitors.
Cancer chemotherapy and pharmacology 2001;48 Suppl 1():S17-9.
2001: Tarik Regad; A Saib; Valérie Lallemand-Breitenbach; Pier Paolo Pandolfi; Hugues de Thé; Mounira K Chelbi-Alix
PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator.
The EMBO journal 2001;20(13):3495-505.
2001: Jose A.. Costoya; Pier Paolo Pandolfi
The role of promyelocytic leukemia zinc finger and promyelocytic leukemia in leukemogenesis and development.
Current opinion in hematology 2001;8(4):212-7.
2001: M Gaboli; P A Kotsi; Carmela Gurrieri; G Cattoretti; S Ronchetti; Carlos Cordon-Cardo; H E Broxmeyer; R Hromas; Pier Paolo Pandolfi
Mzf1 controls cell proliferation and tumorigenesis.
Genes & development 2001;15(13):1625-30.
2001: Valérie Lallemand-Breitenbach; Jun Zhu; F Puvion; Marcel Koken; Nicole Honoré; A Doubeikovsky; E Duprez; Pier Paolo Pandolfi; Edmond Puvion; Paul S Freemont; Hugues de Thé
Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation.
The Journal of experimental medicine 2001;193(12):1361-71.
2001: Ching Liao; Xiang Yuan Wang; H Q Wei; Sherry Q Li; Taha Merghoub; Pier Paolo Pandolfi; Debra J Wolgemuth
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6853-8.
2001: Peng Hu; Sergey Beresten; AJ van Brabant; Tian-Zhang Ye; Pier Paolo Pandolfi; F Brad Johnson; Leonard Guarente; Nathan Ellis
Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.
Human molecular genetics 2001;10(12):1287-98.
2001: Pier Paolo Pandolfi
Transcription therapy for cancer.
Oncogene 2001;20(24):3116-27.
2001: Pier Paolo Pandolfi
Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia.
Human molecular genetics 2001;10(7):769-75.
2001: Eduardo M Rego; ZG Wang; D Peruzzi; LZ He; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Role of promyelocytic leukemia (PML) protein in tumor suppression.
The Journal of experimental medicine 2001;193(4):521-29.
2001: Antonio Di Cristofano; M De Acetis; Andrew Koff; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse.
Nature genetics 2001;27(2):222-4.
2001: François Lehembre; Stefan Müller; Pier Paolo Pandolfi; Anne Dejean
Regulation of Pax3 transcriptional activity by SUMO-1-modified PML.
Oncogene 2001;20(1):1-9.
2001: Taha Merghoub; Carmela Gurrieri; Francesco Piazza; Pier Paolo Pandolfi
Modeling acute promyelocytic leukemia in the mouse: new insights in the pathogenesis of human leukemias.
Blood cells, molecules & diseases 2001;27(1):231-48.
2001: Eduardo M Rego; Pier Paolo Pandolfi
Analysis of the molecular genetics of acute promyelocytic leukemia in mouse models.
Seminars in hematology 2001;38(1):54-70.
2000: LZ He; Mantu Bhaumik; C Tribioli; Eduardo M Rego; Sarah Ivins; Arthur Zelent; Pier Paolo Pandolfi
Two critical hits for promyelocytic leukemia.
Molecular cell 2000;6(5):1131-41.
2000: A Guo; Paolo Salomoni; Jianyuan Luo; A Shih; S Zhong; W Gu; Pier Paolo Pandolfi
The function of PML in p53-dependent apoptosis.
Nature cell biology 2000;2(10):730-6.
2000: Lisa M Toney; Giorgio Cattoretti; J A Graf; Taha Merghoub; Pier Paolo Pandolfi; Riccardo Dalla-Favera; B H Ye; Alexander L Dent
BCL-6 regulates chemokine gene transcription in macrophages.
Nature immunology 2000;1(3):214-20.
2000: Davide Ruggero; ZG Wang; Pier Paolo Pandolfi
The puzzling multiple lives of PML and its role in the genesis of cancer.
BioEssays : news and reviews in molecular, cellular and developmental biology 2000;22(9):827-35.
2000: Eduardo M Rego; LZ He; RP Warrell; ZG Wang; Pier Paolo Pandolfi
Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10173-8.
2000: Maria Barna; N Hawe; Lee Niswander; Pier Paolo Pandolfi
Plzf regulates limb and axial skeletal patterning.
Nature genetics 2000;25(2):166-72.
2000: S Zhong; Paolo Salomoni; Pier Paolo Pandolfi
The transcriptional role of PML and the nuclear body.
Nature cell biology 2000;2(5):E85-90.
2000: S Zhong; S Müller; S Ronchetti; P S Freemont; A Dejean; Pier Paolo Pandolfi
Role of SUMO-1-modified PML in nuclear body formation.
Blood 2000;95(9):2748-52.
2000: S Zhong; Paolo Salomoni; S Ronchetti; A Guo; Davide Ruggero; Pier Paolo Pandolfi
Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.
The Journal of experimental medicine 2000;191(4):631-40.
2000: Antonio Di Cristofano; Pier Paolo Pandolfi
The multiple roles of PTEN in tumor suppression.
Cell 2000;100(4):387-90.
1999: S Zhong; Peng Hu; Tian-Zhang Ye; Rodica Stan; Nathan Ellis; Pier Paolo Pandolfi
A role for PML and the nuclear body in genomic stability.
Oncogene 1999;18(56):7941-7.
1999: S Zhong; L Delva; Christophe Rachez; C Cenciarelli; D Gandini; H Zhang; Sundeep Kalantry; Leonard P Freedman; Pier Paolo Pandolfi
A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.
Nature genetics 1999;23(3):287-95.
1999: G Tremml; C Dominguez; Vittorio Rosti; Z Zhang; Pier Paolo Pandolfi; P Keller; Monica Bessler
Increased sensitivity to complement and a decreased red blood cell life span in mice mosaic for a nonfunctional Piga gene.
Blood 1999;94(9):2945-54.
1999: JO Lee; Haijuan Yang; Maria-Magdalena Georgescu; Antonio Di Cristofano; T Maehama; Y Shi; J E Dixon; Pier Paolo Pandolfi; Nikola P Pavletich
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.
Cell 1999;99(3):323-34.
1999: Miera B Harris; Chung-Che Chang; Michael Berton; Nika N Danial; J Zhang; D Kuehner; B H Ye; M Kvatyuk; Pier Paolo Pandolfi; Giorgio Cattoretti; Riccardo Dalla-Favera; Paul B Rothman
Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching.
Molecular and cellular biology 1999;19(10):7264-75.
1999: Antonio Di Cristofano; P Kotsi; Y F Peng; Carlos Cordon-Cardo; K B Elkon; Pier Paolo Pandolfi
Impaired Fas response and autoimmunity in Pten+/- mice.
Science (New York, N.Y.) 1999;285(5436):2122-5.
1999: LZ He; Taha Merghoub; Pier Paolo Pandolfi
In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications.
Oncogene 1999;18(38):5278-92.
1998: Steven L Soignet; Peter Maslak; ZG Wang; Suresh C Jhanwar; Elizabeth Calleja; L J Dardashti; D Corso; A DeBlasio; JL Gabrilove; David A Scheinberg; Pier Paolo Pandolfi; RP Warrell
Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide.
The New England journal of medicine 1998;339(19):1341-8.
1998: RP Warrell; LZ He; Victoria M Richon; Elizabeth Calleja; Pier Paolo Pandolfi
Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase.
Journal of the National Cancer Institute 1998;90(21):1621-5.
1998: ZG Wang; Davide Ruggero; S Ronchetti; S Zhong; M Gaboli; R Rivi; Pier Paolo Pandolfi
PML is essential for multiple apoptotic pathways.
Nature genetics 1998;20(3):266-72.
1998: ZG Wang; R Rivi; L Delva; A König; David A Scheinberg; C Gambacorti-Passerini; JL Gabrilove; RP Warrell; Pier Paolo Pandolfi
Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner.
Blood 1998;92(5):1497-504.
1998: Antonio Di Cristofano; B Pesce; Carlos Cordon-Cardo; Pier Paolo Pandolfi
Pten is essential for embryonic development and tumour suppression.
Nature genetics 1998;19(4):348-55.
1998: M Gaboli; D Gandini; L Delva; ZG Wang; Pier Paolo Pandolfi
Acute promyelocytic leukemia as a model for cross-talk between interferon and retinoic acid pathways: from molecular biology to clinical applications.
Leukemia & lymphoma 1998;30(1-2):11-22.
1998: Pier Paolo Pandolfi
Knocking in and out genes and trans genes: the use of the engineered mouse to study normal and aberrant hemopoiesis.
Seminars in hematology 1998;35(2):136-48.
1998: ZG Wang; L Delva; M Gaboli; R Rivi; M Giorgio; Carlos Cordon-Cardo; F Grosveld; Pier Paolo Pandolfi
Role of PML in cell growth and the retinoic acid pathway.
Science (New York, N.Y.) 1998;279(5356):1547-51.
1998: Antonio Di Cristofano; N Carpino; N Dunant; G Friedland; Ryuji Kobayashi; Annabel Strife; David Wisniewski; Bayard Clarkson; Pier Paolo Pandolfi; Marilyn D Resh
Molecular cloning and characterization of p56dok-2 defines a new family of RasGAP-binding proteins.
The Journal of biological chemistry 1998;273(9):4827-30.
1998: LZ He; Fabien Guidez; C Tribioli; D Peruzzi; M Ruthardt; Arthur Zelent; Pier Paolo Pandolfi
Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
Nature genetics 1998;18(2):126-35.
1997: Sundeep Kalantry; L Delva; M Gaboli; D Gandini; M Giorgio; N Hawe; LZ He; D Peruzzi; R Rivi; C Tribioli; ZG Wang; H Zhang; Pier Paolo Pandolfi
Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia.
Journal of cellular physiology 1997;173(2):288-96.
1997: L Longo; Anne Elisabeth Bygrave; F G Grosveld; Pier Paolo Pandolfi
The chromosome make-up of mouse embryonic stem cells is predictive of somatic and germ cell chimaerism.
Transgenic research 1997;6(5):321-8.
1997: Vittorio Rosti; G Tremml; V da C Soares; Pier Paolo Pandolfi; Lucio Luzzatto; Monica Bessler
Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion.
The Journal of clinical investigation 1997;100(5):1028-36.
1997: A König; L Wrazel; RP Warrell; R Rivi; Pier Paolo Pandolfi; Ann Jakubowski; JL Gabrilove
Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines.
Blood 1997;90(2):562-70.
1997: B H Ye; Giorgio Cattoretti; Qiong Shen; J Zhang; N Hawe; R de Waard; Conrad Leung; M Nouri-Shirazi; Attilio Orazi; Raju S K Chaganti; Paul B Rothman; A M Stall; Pier Paolo Pandolfi; Riccardo Dalla-Favera
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation.
Nature genetics 1997;16(2):161-70.
1997: LZ He; C Tribioli; R Rivi; D Peruzzi; P G Pelicci; V da C Soares; Giorgio Cattoretti; Pier Paolo Pandolfi
Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(10):5302-7.
1996: K Nason-Burchenal; D Gandini; Marina Botto; J Allopenna; J R Seale; N C Cross; J M Goldman; Ethan Dmitrovsky; Pier Paolo Pandolfi
Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line.
Blood 1996;88(10):3926-36.
1996: J R Seale; S Varma; D M Swirsky; Pier Paolo Pandolfi; John M Goldman; Nicholas C P Cross
Quantification of PML-RAR alpha transcripts in acute promyelocytic leukaemia: explanation for the lack of sensitivity of RT-PCR for the detection of minimal residual disease and induction of the leukaemia-specific mRNA by alpha interferon.
British journal of haematology 1996;95(1):95-101.
1996: Pier Paolo Pandolfi
PML, PLZF and NPM genes in the molecular pathogenesis of acute promyelocytic leukemia.
Haematologica 1996;81(5):472-82.
1996: Giuliana Pelicci; Luciana Dente; A De Giuseppe; B Verducci-Galletti; S Giuli; S Mele; C Vetriani; M Giorgio; Pier Paolo Pandolfi; Gianni Cesareni; Pier Giuseppe Pelicci
A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.
Oncogene 1996;13(3):633-41.
1995: Pier Paolo Pandolfi; F Sonati; R Rivi; P Mason; F Grosveld; Lucio Luzzatto
Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress.
The EMBO journal 1995;14(21):5209-15.
1995: J Maher; Pier Paolo Pandolfi; Irene A G Roberts
Selection of a highly enriched population of retrovirus-infected human hematopoietic progenitor cells using SNL fibroblasts.
Leukemia 1995;9 Suppl 1():S29-33.
1995: C Lavau; Agnès Marchio; Marta Fagioli; J Jansen; B Falini; P Lebon; F Grosveld; Pier Paolo Pandolfi; P G Pelicci; Anne Dejean
The acute promyelocytic leukaemia-associated PML gene is induced by interferon.
Oncogene 1995;11(5):871-6.
1995: Pier Paolo Pandolfi; M E Roth; A Karis; M W Leonard; E Dzierzak; Frank Grosveld; James Douglas Engel; M H Lindenbaum
Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis.
Nature genetics 1995;11(1):40-4.
1994: Daniela Diverio; Pier Paolo Pandolfi; V Rossi; Andrea Biondi; Pier Giuseppe Pelicci; Francesco Lo Coco
Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR.
Leukemia 1994;8(7):1105-7.
1994: Francesco Grignani; Marta Fagioli; Myriam Alcalay; L Longo; Pier Paolo Pandolfi; Emilio Donti; Andrea Biondi; Francesco Lo Coco; F Grignani; Pier Giuseppe Pelicci
Acute promyelocytic leukemia: from genetics to treatment.
Blood 1994;83(1):10-25.
1994: Daniela Diverio; Pier Paolo Pandolfi; V Rossi; Andrea Biondi; Pier Giuseppe Pelicci; Francesco Lo Coco
Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR.
Leukemia 1994;8 Suppl 2():S63-5.
1993: Daniela Diverio; Pier Paolo Pandolfi; Andrea Biondi; Giuseppe Avvisati; Maria Concetta Petti; Franco Mandelli; Giuliana Pelicci; Francesco Lo Coco
Absence of reverse transcription-polymerase chain reaction detectable residual disease in patients with acute promyelocytic leukemia in long-term remission.
Blood 1993;82(12):3556-9.
1993: Carlo Gambacorti-Passerini; Francesco Grignani; Flavio Arienti; Pier Paolo Pandolfi; P G Pelicci; Giorgio Parmiani
Human CD4 lymphocytes specifically recognize a peptide representing the fusion region of the hybrid protein pml/RAR alpha present in acute promyelocytic leukemia cells.
Blood 1993;81(5):1369-75.
1993: Andrea Biondi; Alessandro Rambaldi; Pier Paolo Pandolfi; Myriam Alcalay; L Longo; V Rossi; Giovanni Giudici; Francesco Lo Coco; Pier Giuseppe Pelicci
Molecular genetics of the t(15;17) translocation in acute promyelocytic leukemia.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1993;131():345-59.
1992: Francesco Lo Coco; Daniela Diverio; Pier Paolo Pandolfi; Andrea Biondi; V Rossi; Giuseppe Avvisati; Alessandro Rambaldi; William Arcese; Maria Concetta Petti; Giovanna Meloni
Molecular evaluation of residual disease as a predictor of relapse in acute promyelocytic leukaemia.
Lancet 1992;340(8833):1437-8.
1992: Andrea Biondi; Alessandro Rambaldi; Pier Paolo Pandolfi; V Rossi; Giovanni Giudici; Myriam Alcalay; Francesco Lo Coco; Daniela Diverio; E M Pogliani; E M Lanzi
Molecular monitoring of the myl/retinoic acid receptor-alpha fusion gene in acute promyelocytic leukemia by polymerase chain reaction.
Blood 1992;80(2):492-7.
1992: Marta Fagioli; Myriam Alcalay; Pier Paolo Pandolfi; L Venturini; Andrea Mencarelli; A Simeone; D Acampora; Francesco Grignani; Pier Giuseppe Pelicci
Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms.
Oncogene 1992;7(6):1083-91.
1992: Myriam Alcalay; D Zangrilli; Marta Fagioli; Pier Paolo Pandolfi; Andrea Mencarelli; Francesco Lo Coco; Andrea Biondi; Francesco Grignani; Pier Giuseppe Pelicci
Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(11):4840-4.
1992: Luisa Lanfrancone; G Pengue; Pier Paolo Pandolfi; Anna Elisabetta Salcini; A Giacomucci; L Longo; Emilio Donti; P De Luca; Girolama La Mantia; Pier Giuseppe Pelicci
Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22.
Genomics 1992;12(4):720-8.
1992: Pier Paolo Pandolfi; Myriam Alcalay; Marta Fagioli; D Zangrilli; Andrea Mencarelli; Daniela Diverio; Andrea Biondi; Francesco Lo Coco; Alessandro Rambaldi; Francesco Grignani
Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.
The EMBO journal 1992;11(4):1397-407.
1992: Francesco Lo Coco; Daniela Diverio; F D'Adamo; Giuseppe Avvisati; Giuliana Alimena; M Nanni; Myriam Alcalay; Pier Paolo Pandolfi; Pier Giuseppe Pelicci
PML/RAR-alpha rearrangement in acute promyelocytic leukaemias apparently lacking the t(15;17) translocation.
European journal of haematology 1992;48(3):173-6.
1992: Pier Paolo Pandolfi; Myriam Alcalay; L Longo; Marta Fagioli; D Zangrilli; Francesco Grignani; A Menccarelli; Andrea Biondi; Alessandro Rambaldi; F LoCoco
Molecular genetics of the t(15;17) of acute promyelocytic leukemia (APPL).
Leukemia 1992;6 Suppl 3():120S-122S.
1991: Francesco Lo Coco; Giuseppe Avvisati; Daniela Diverio; Andrea Biondi; Pier Paolo Pandolfi; Myriam Alcalay; Giulio De Rossi; Maria Concetta Petti; A Cantù-Rajnoldi; D Pasqualetti
Rearrangements of the RAR-alpha gene in acute promyelocytic leukaemia: correlations with morphology and immunophenotype.
British journal of haematology 1991;78(4):494-9.
1991: Pier Paolo Pandolfi; Francesco Grignani; Myriam Alcalay; Andrea Mencarelli; Andrea Biondi; F LoCoco; F Grignani; Pier Giuseppe Pelicci
Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.
Oncogene 1991;6(7):1285-92.
1991: Francesco Lo Coco; Giuseppe Avvisati; Daniela Diverio; Maria Concetta Petti; Myriam Alcalay; Pier Paolo Pandolfi; D Zangrilli; Andrea Biondi; Alessandro Rambaldi; Maria Luisa Moleti
Molecular evaluation of response to all-trans-retinoic acid therapy in patients with acute promyelocytic leukemia.
Blood 1991;77(8):1657-9.
1991: Andrea Biondi; Alessandro Rambaldi; Myriam Alcalay; Pier Paolo Pandolfi; Francesco Lo Coco; Daniela Diverio; V Rossi; Andrea Mencarelli; L Longo; D Zangrilli
RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemia.
Blood 1991;77(7):1418-22.
1991: Myriam Alcalay; D Zangrilli; Pier Paolo Pandolfi; L Longo; Andrea Mencarelli; A Giacomucci; M Rocchi; Andrea Biondi; Alessandro Rambaldi; Francesco Lo Coco
Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(5):1977-81.
1990: L Longo; Pier Paolo Pandolfi; Andrea Biondi; Alessandro Rambaldi; Andrea Mencarelli; Francesco Lo Coco; Daniela Diverio; Luigi Pegoraro; G Avanzi; Antonio Tabilio
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.
The Journal of experimental medicine 1990;172(6):1571-5.