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Sandy Pang

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Edwin Chiu Yuen Chow; K Sandy Pang
Why we need proper PBPK models to examine intestine and liver oral drug absorption.
Matthew R Durk; Eason Lee; David S Miller; Reina Bendayan; Christopher R Campos; Ronald E Cannon; Gary N Y Chan; Edwin Chiu Yuen Chow; John C Peart; K Sandy Pang
1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.
K Sandy Pang; Edwin Chiu Yuen Chow
Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.

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All Publications

2013: Edwin Chiu Yuen Chow; K Sandy Pang
Why we need proper PBPK models to examine intestine and liver oral drug absorption.
Current drug metabolism 2013;14(1):57-79.
2012: Matthew R Durk; Eason Lee; David S Miller; Reina Bendayan; Christopher R Campos; Ronald E Cannon; Gary N Y Chan; Edwin Chiu Yuen Chow; John C Peart; K Sandy Pang
1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.
Journal of neurochemistry 2012;123(6):944-53.
2012: K Sandy Pang; Edwin Chiu Yuen Chow
Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(10):1869-77.
2012: Amin Rostami-Hodjegan; Ikumi Tamai; K Sandy Pang
Physiologically based pharmacokinetic (PBPK) modeling: it is here to stay!
Biopharmaceutics & drug disposition 2012;33(2):47-50.
2012: Joseph A Grillo; Eva Gil Berglund; Brian P Booth; Julie Bullock; Lawrence J Lesko; Min Lu; K Sandy Pang; Atiqur Rahman; Kathy Robie-Suh; Lei Zhang; Ping Zhao; Shiew-Mei Huang
Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice.
Biopharmaceutics & drug disposition 2012;33(2):99-110.
2012: Ping Zhao; Jenny H Zheng; Eva Gil Berglund; Darrell R. Abernethy; Vikram Arya; Arthur J Atkinson; Joseph A Grillo; Lawrence J Lesko; K Sandy Pang; Kellie S Reynolds; Pengfei Song; Yuichi Sugiyama; Manuela de L T Vieira; Ta-Chen Wu; Lei Zhang; Shiew-Mei Huang
Evaluation of exposure change of nonrenally eliminated drugs in patients with chronic kidney disease using physiologically based pharmacokinetic modeling and simulation.
Journal of clinical pharmacology 2012;52(1 Suppl):91S-108S.
2011: Edwin Chiu Yuen Chow; Matthew R Durk; Carolyn L Cummins; K Sandy Pang
1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
The Journal of pharmacology and experimental therapeutics 2011;337(3):846-59.
2011: Han-Joo Maeng; Matthew R Durk; Edwin Chiu Yuen Chow; Ragia Ghoneim; K Sandy Pang
1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac.
Biopharmaceutics & drug disposition 2011;32(2):112-25.
2011: Ansar A Khan; Edwin Chiu Yuen Chow; Robert J Porte; K Sandy Pang; Geny M M Groothuis
The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices.
Toxicology in vitro : an international journal published in association with BIBRA 2011;25(1):80-90.
2011: J Fan; H-J Maeng; Y Du; D Kwan; K Sandy Pang
Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;42(1-2):19-29.
2010: K Sandy Pang; Matthew R Durk
Physiologically-based pharmacokinetic modeling for absorption, transport, metabolism and excretion.
Journal of pharmacokinetics and pharmacodynamics 2010;37(6):591-615.
2010: Jianghong Fan; Shu Chen; Edwin Chiu Yuen Chow; K Sandy Pang
PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism.
Current drug metabolism 2010;11(9):743-61.
2010: Huadong Sun; K Sandy Pang
Physiological modeling to understand the impact of enzymes and transporters on drug and metabolite data and bioavailability estimates.
Pharmaceutical research 2010;27(7):1237-54.
2010: Jianghong Fan; Han-Joo Maeng; K Sandy Pang
Interplay of transporters and enzymes in the Caco-2 cell monolayer: I. effect of altered apical secretion.
Biopharmaceutics & drug disposition 2010;31(4):215-27.
2010: Edwin Chiu Yuen Chow; Huadong Sun; Ansar A Khan; Geny M M Groothuis; K Sandy Pang
Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo.
Biopharmaceutics & drug disposition 2010;31(1):91-108.
2009: K Sandy Pang; Han-Joo Maeng; Jianghong Fan
Interplay of transporters and enzymes in drug and metabolite processing.
Molecular pharmaceutics 2009;6(6):1734-55.
2009: Edwin Chiu Yuen Chow; Han-Joo Maeng; Shanjun Liu; Ansar A Khan; Geny M M Groothuis; K Sandy Pang
1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo.
Biopharmaceutics & drug disposition 2009;30(8):457-75.
2009: Jianghong Fan; Shanjun Liu; Yimin Du; Jodi Morrison; Robert Shipman; K Sandy Pang
Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer.
The Journal of pharmacology and experimental therapeutics 2009;330(2):389-402.
2009: Ansar A Khan; Edwin Chiu Yuen Chow; Robert J Porte; K Sandy Pang; Geny M M Groothuis
Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver.
Biopharmaceutics & drug disposition 2009;30(5):241-58.
2009: Ansar A Khan; Edwin Chiu Yuen Chow; Anne-miek M A van Loenen-Weemaes; Robert J Porte; K Sandy Pang; Geny M M Groothuis
Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;37(2):115-25.
2009: K Sandy Pang
Safety testing of metabolites: Expectations and outcomes.
Chemico-biological interactions 2009;179(1):45-59.
2008: K Sandy Pang; Marilyn E Morris; Huadong Sun
Formed and preformed metabolites: facts and comparisons.
The Journal of pharmacy and pharmacology 2008;60(10):1247-75.
2008: Huadong Sun; Li Zhang; Edwin Chiu Yuen Chow; Ge Lin; Zhong Zuo; K Sandy Pang
A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition.
The Journal of pharmacology and experimental therapeutics 2008;326(1):117-26.
2008: Edwin Chiu Yuen Chow; Lichuan Liu; Noam Ship; Ronald H Kluger; K Sandy Pang
Role of haptoglobin on the uptake of native and beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] cross-linked human hemoglobins in isolated perfused rat livers.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(5):937-45.
2008: Huadong Sun; Edwin Chiu Yuen Chow; Shanjun Liu; Yimin Du; K Sandy Pang
The Caco-2 cell monolayer: usefulness and limitations.
Expert opinion on drug metabolism & toxicology 2008;4(4):395-411.
2008: Huadong Sun; K Sandy Pang
Permeability, transport, and metabolism of solutes in Caco-2 cell monolayers: a theoretical study.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(1):102-23.
2007: Lichuan Liu; Huadong Sun; Wiqas Y Valji; K Sandy Pang
Transporters, enzymes, and enalapril removal in a rat (CC531-induced) liver metastatic model.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(5):G1078-88.
2007: K Sandy Pang; Michael WEIss; Panos Macheras
Advanced pharmacokinetic models based on organ clearance, circulatory, and fractal concepts.
The AAPS journal 2007;9(2):E268-83.
2006: Huadong Sun; Lichuan Liu; K Sandy Pang
Increased estrogen sulfation of estradiol 17beta-D-glucuronide in metastatic tumor rat livers.
The Journal of pharmacology and experimental therapeutics 2006;319(2):818-31.
2006: Lichuan Liu; K Sandy Pang
An integrated approach to model hepatic drug clearance.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;29(3-4):215-30.
2006: Shanjun Liu; Debbie Tam; Xianghai Chen; K Sandy Pang
P-glycoprotein and an unstirred water layer barring digoxin absorption in the vascularly perfused rat small intestine preparation: induction studies with pregnenolone-16alpha-carbonitrile.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(9):1468-79.
2006: Lichuan Liu; Yunhai Cui; Alfred Y Chung; Yoshihisa Shitara; Yuichi Sugiyama; Dietrich Keppler; K Sandy Pang
Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers.
The Journal of pharmacology and experimental therapeutics 2006;318(1):395-402.
2006: Xianghai Chen; Frank Chen; Shanjun Liu; Hartmut Glaeser; Paul A Dawson; Alan Hofmann; Richard B Kim; Benjamin L Shneider; K Sandy Pang
Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor.
Molecular pharmacology 2006;69(6):1913-23.
2006: Margaret M Doherty; Karen Poon; Carol Tsang; K Sandy Pang
Transport is not rate-limiting in morphine glucuronidation in the single-pass perfused rat liver preparation.
The Journal of pharmacology and experimental therapeutics 2006;317(2):890-900.
2005: Lichuan Liu; Ernie Mak; Rommel G Tirona; Eugene Tan; Phyllis M Novikoff; Pijun Wang; Allan W Wolkoff; K Sandy Pang
Vascular binding, blood flow, transporter, and enzyme interactions on the processing of digoxin in rat liver.
The Journal of pharmacology and experimental therapeutics 2005;315(1):433-48.
2005: Cheng Chang; K Sandy Pang; Peter Swaan; Sean Ekins
Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1.
The Journal of pharmacology and experimental therapeutics 2005;314(2):533-41.
2005: Noam J Ship; Ayça Toprak; Roseanna P Lai; Eric Tseng; Ronald Kluger; K Sandy Pang
Binding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat.
American journal of physiology. Gastrointestinal and liver physiology 2005;288(6):G1301-9.
2005: Lichuan Liu; K Sandy Pang
The roles of transporters and enzymes in hepatic drug processing.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(1):1-9.
2003: K Sandy Pang
Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the Gillette Review Series).
Drug metabolism and disposition: the biological fate of chemicals 2003;31(12):1507-19.
2003: Soichiro Hata; Pijun Wang; Nicole Eftychiou; Meenakshisundaram Ananthanarayanan; Ashok K Batta; Gerald Salen; K Sandy Pang; Allan W Wolkoff
Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake.
American journal of physiology. Gastrointestinal and liver physiology 2003;285(5):G829-39.
2003: Debbie Tam; Huadong Sun; K Sandy Pang
Influence of P-glycoprotein, transfer clearances, and drug binding on intestinal metabolism in Caco-2 cell monolayers or membrane preparations: a theoretical analysis.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(10):1214-26.
2003: Andreas Schwab; Lei Tao; Manjinder Kang; Lingjie Meng; K Sandy Pang
Moment analysis of metabolic heterogeneity: conjugation of benzoate with glycine in rat liver studied by multiple indicator dilution technique.
The Journal of pharmacology and experimental therapeutics 2003;305(1):279-89.
2003: Robert Houle; Jennifer Raoul; Jean-François Lévesque; K Sandy Pang; Deborah A Nicoll-Griffith; José M Silva
Retention of transporter activities in cryopreserved, isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(4):447-51.
2003: Debbie Tam; Rommel G Tirona; K Sandy Pang
Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption.
Drug metabolism and disposition: the biological fate of chemicals 2003;31(4):373-83.
2002: Ling-Jie Meng; Pijun Wang; Allan W Wolkoff; Richard B Kim; Rommel G Tirona; Alan Hofmann; K Sandy Pang
Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2.
Hepatology (Baltimore, Md.) 2002;35(5):1031-40.
2001: D Cong; A K Fong; R Lee; K Sandy Pang
Absorption of benzoic acid in segmental regions of the vascularly perfused rat small intestine preparation.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(12):1539-47.
2001: Andreas Schwab; L Tao; T Yoshimura; André Simard; F Barker; K Sandy Pang
Hepatic uptake and metabolism of benzoate: a multiple indicator dilution, perfused rat liver study.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(6):G1124-36.
2001: Eugene Tan; T Lu; K Sandy Pang
Futile cycling of estrone sulfate and estrone in the recirculating perfused rat liver preparation.
The Journal of pharmacology and experimental therapeutics 2001;297(1):423-36.
2001: Eugene Tan; K Sandy Pang
Sulfation is rate limiting in the futile cycling between estrone and estrone sulfate in enriched periportal and perivenous rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(3):335-46.
2000: Andreas Schwab; K Sandy Pang
The multiple indicator dilution method and its utility in risk assessment.
Environmental health perspectives 2000;108 Suppl 5():861-72.
2000: T N Abu-Zahra; K Sandy Pang
Effect of zonal transport and metabolism on hepatic removal: enalapril hydrolysis in zonal, isolated rat hepatocytes in vitro and correlation with perfusion data.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(7):807-13.
2000: T N Abu-Zahra; Allan W Wolkoff; R B Kim; K Sandy Pang
Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(7):801-6.
2000: Margaret M Doherty; K Sandy Pang
Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation.
Pharmaceutical research 2000;17(3):291-8.
2000: D Cong; M Doherty; K Sandy Pang
A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(2):224-35.
1999: Rommel G Tirona; Eugene Tan; G Meier; K Sandy Pang
Uptake and glutathione conjugation of ethacrynic acid and efflux of the glutathione adduct by periportal and perivenous rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1999;291(3):1210-9.
1999: Rommel G Tirona; K Sandy Pang
Bimolecular glutathione conjugation kinetics of ethacrynic acid in rat liver: in vitro and perfusion studies.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1230-41.
1999: GL Sirianni; K Sandy Pang
Inhibition of esterolysis of enalapril by paraoxon increases the urinary clearance in isolated perfused rat kidney.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(8):931-6.
1999: Andreas Schwab; K Sandy Pang
The multiple indicator-dilution method for the study of enzyme heterogeneity in liver: theoretical basis.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(6):746-55.
1999: Eugene Tan; Rommel G Tirona; K Sandy Pang
Lack of zonal uptake of estrone sulfate in enriched periportal and perivenous isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 1999;27(3):336-41.
1999: W Geng; K Sandy Pang
Differences in excretion of hippurate, as a metabolite of benzoate and as an administered species, in the single-pass isolated perfused rat kidney explained.
The Journal of pharmacology and experimental therapeutics 1999;288(2):597-606.
1998: K Sandy Pang; P J Wang; A Y Chung; Allan W Wolkoff
The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein.
Hepatology (Baltimore, Md.) 1998;28(5):1341-6.
1998: Rommel G Tirona; Andreas Schwab; W Geng; K Sandy Pang
Hepatic clearance models: comparison of the dispersion and Goresky models in outflow profiles from multiple indicator dilution rat liver studies.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(5):465-75.
1998: Andreas Schwab; W Geng; K Sandy Pang
Application of the dispersion model for description of the outflow dilution profiles of noneliminated reference indicators in rat liver perfusion studies.
Journal of pharmacokinetics and biopharmaceutics 1998;26(2):163-81.
1998: GL Sirianni; K Sandy Pang
Intracellular and not intraluminal esterolysis of enalapril in kidney. Studies with the single pass perfused nonfiltering rat kidney.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(4):324-31.
1998: W Geng; Andreas Schwab; T Horie; CA Goresky; K Sandy Pang
Hepatic uptake of bromosulfophthalein-glutathione in perfused Eisai hyperbilirubinemic mutant rat liver: a multiple-indicator dilution study.
The Journal of pharmacology and experimental therapeutics 1998;284(2):480-92.
1998: T Yoshimura; Andreas Schwab; L Tao; F Barker; K Sandy Pang
Hepatic uptake of hippurate: a multiple-indicator dilution, perfused rat liver study.
The American journal of physiology 1998;274(1 Pt 1):G10-20.
1998: M Chiba; Andreas Schwab; CA Goresky; K Sandy Pang
Carrier-mediated entry of 4-methylumbelliferyl sulfate: characterization by the multiple-indicator dilution technique in perfused rat liver.
Hepatology (Baltimore, Md.) 1998;27(1):134-46.
1997: Margaret M Doherty; K Sandy Pang
First-pass effect: significance of the intestine for absorption and metabolism.
Drug and chemical toxicology 1997;20(4):329-44.
1997: S Ouwerkerk-Mahadevan; Rommel G Tirona; R A Ripping; J H Ploemen; Peter J van Bladeren; K Sandy Pang; J H van Boom; Gerard J Mulder
Inhibition of glutathione conjugation by glutathione analogues in the perfused rat liver. Effect of esterification on the potency of gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(10):1137-43.
1997: GL Sirianni; K Sandy Pang
Organ clearance concepts: new perspectives on old principles.
Journal of pharmacokinetics and biopharmaceutics 1997;25(4):449-70.
1997: J Chen; K Sandy Pang
Effect of flow on first-pass metabolism of drugs: single pass studies on 4-methylumbelliferone conjugation in the serially perfused rat intestine and liver preparations.
The Journal of pharmacology and experimental therapeutics 1997;280(1):24-31.
1996: Rommel G Tirona; K Sandy Pang
Sequestered endoplasmic reticulum space for sequential metabolism of salicylamide. Coupling of hydroxylation and glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(8):821-33.
1996: A M Hassen; D Lam; M Chiba; Eugene Tan; W Geng; K Sandy Pang
Uptake of sulfate conjugates by isolated rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 1996;24(7):792-8.
1996: I A Sherman; John A Dlugosz; F Barker; F M Sadeghi; K Sandy Pang
Dynamics of arterial and portal venous flow interactions in perfused rat liver: an intravital microscopic study.
The American journal of physiology 1996;271(1 Pt 1):G201-10.
1995: W P Geng; Andreas Schwab; CA Goresky; K Sandy Pang
Carrier-mediated uptake and excretion of bromosulfophthalein-glutathione in perfused rat liver: a multiple indicator dilution study.
Hepatology (Baltimore, Md.) 1995;22(4 Pt 1):1188-207.
1995: W P Geng; K Poon; K Sandy Pang
An understanding of flow- and diffusion-limited vs. carrier-mediated hepatic transport: a simulation study.
Journal of pharmacokinetics and biopharmaceutics 1995;23(4):347-78.
1995: K Sandy Pang; F Barker; André Simard; Andreas Schwab; CA Goresky
Sulfation of acetaminophen by the perfused rat liver: the effect of red blood cell carriage.
Hepatology (Baltimore, Md.) 1995;22(1):267-82.
1995: M V St-Pierre; K Sandy Pang
Concentration-dependent metabolism of diazepam in mouse liver.
Journal of pharmacokinetics and biopharmaceutics 1995;23(3):243-66.
1995: M Chiba; K Sandy Pang
Glutathione depletion kinetics with acetaminophen. A simulation study.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(6):622-30.
1995: C A Snel; K Sandy Pang; Gerard J Mulder
Glutathione conjugation of bromosulfophthalein in relation to hepatic glutathione content in the rat in vivo and in the perfused rat liver.
Hepatology (Baltimore, Md.) 1995;21(5):1387-94.
1995: K Poon; K Sandy Pang
Benzoic acid glycine conjugation in the isolated perfused rat kidney.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(2):255-60.
1995: K Sandy Pang
Kinetics of sequential metabolism. Contribution of parallel, primary metabolic pathways to the formation of a common, secondary metabolite.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(2):166-77.
1995: K Sandy Pang
Acinar factors in drug processing: protein binding, futile cycling, and cosubstrate.
Drug metabolism reviews 1995;27(1-2):325-68.
1994: K Sandy Pang; I A Sherman; Andreas Schwab; W Geng; F Barker; John A Dlugosz; G Cuerrier; CA Goresky
Role of the hepatic artery in the metabolism of phenacetin and acetaminophen: intravital microscopic and multiple-indicator dilution study in perfused rat liver.
Hepatology (Baltimore, Md.) 1994;20(3):672-83.
1994: K Sandy Pang; F Barker; Andreas Schwab; CA Goresky
Demonstration of rapid entry and a cellular binding space for salicylamide in perfused rat liver: a multiple indicator dilution study.
The Journal of pharmacology and experimental therapeutics 1994;270(1):285-95.
1994: M Chiba; K Poon; J Hollands; K Sandy Pang
Glycine conjugation activity of benzoic acid and its acinar localization in the perfused rat liver.
The Journal of pharmacology and experimental therapeutics 1994;268(1):409-16.
1994: X Xu; Andreas Schwab; F Barker; CA Goresky; K Sandy Pang
Salicylamide sulfate cell entry in perfused rat liver: a multiple-indicator dilution study.
Hepatology (Baltimore, Md.) 1994;19(1):229-44.
1993: Y Zhao; C A Snel; Gerard J Mulder; K Sandy Pang
Localization of glutathione conjugation activities toward bromosulfophthalein in perfused rat liver. Studies with the multiple indicator dilution technique.
Drug metabolism and disposition: the biological fate of chemicals 1993;21(6):1070-8.
1993: M Chiba; K Sandy Pang
Effect of protein binding on 4-methylumbelliferyl sulfate desulfation kinetics in perfused rat liver.
The Journal of pharmacology and experimental therapeutics 1993;266(2):492-9.
1993: I A de Lannoy; K Sandy Pang
Combined recirculation of the rat liver and kidney: studies with enalapril and enalaprilat.
Journal of pharmacokinetics and biopharmaceutics 1993;21(4):423-56.
1993: I A de Lannoy; F Barker; K Sandy Pang
Formed and preformed metabolite excretion clearances in liver, a metabolite formation organ: studies on enalapril and enalaprilat in the single-pass and recirculating perfused rat liver.
Journal of pharmacokinetics and biopharmaceutics 1993;21(4):395-422.
1993: C A Snel; Y Zhao; Gerard J Mulder; K Sandy Pang
Methods for the quantitation of bromosulfophthalein and its glutathione conjugate in biological fluids.
Analytical biochemistry 1993;212(1):28-34.
1993: M V St-Pierre; K Sandy Pang
Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1437-45.
1993: M V St-Pierre; K Sandy Pang
Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1429-36.
1993: M Polhuijs; I Gasinska; W F Cherry; Gerard J Mulder; K Sandy Pang
Stereoselectivity in glutathione conjugation and amidase-catalyzed hydrolysis of the 2-bromoisovalerylurea enantiomers in the single-pass perfused rat liver.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1406-12.
1993: S Ratna; M Chiba; L Bandyopadhyay; K Sandy Pang
Futile cycling between 4-methylumbelliferone and its conjugates in perfused rat liver.
Hepatology (Baltimore, Md.) 1993;17(5):838-53.
1992: Andreas Schwab; I A de Lannoy; CA Goresky; K Poon; K Sandy Pang
Enalaprilat handling by the kidney: barrier-limited cell entry.
The American journal of physiology 1992;263(5 Pt 2):F858-69.
1992: CA Goresky; K Sandy Pang; Andreas Schwab; F Barker; W F Cherry; G G Bach
Uptake of a protein-bound polar compound, acetaminophen sulfate, by perfused rat liver.
Hepatology (Baltimore, Md.) 1992;16(1):173-90.
1992: M Weiss; K Sandy Pang
Dynamics of drug distribution. I. Role of the second and third curve moments.
Journal of pharmacokinetics and biopharmaceutics 1992;20(3):253-78.
1992: M V St-Pierre; P I Lee; K Sandy Pang
A comparative investigation of hepatic clearance models: predictions of metabolite formation and elimination.
Journal of pharmacokinetics and biopharmaceutics 1992;20(2):105-45.
1992: K Sandy Pang; X Xu; M V St-Pierre
Determinants of metabolite disposition.
Annual review of pharmacology and toxicology 1992;32():623-69.
1991: K Sandy Pang; N Xu; CA Goresky
D2O as a substitute for 3H2O, as a reference indicator in liver multiple-indicator dilution studies.
The American journal of physiology 1991;261(6 Pt 1):G929-36.
1991: K Sandy Pang; F Barker; W F Cherry; CA Goresky
Esterases for enalapril hydrolysis are concentrated in the perihepatic venous region of the rat liver.
The Journal of pharmacology and experimental therapeutics 1991;257(1):294-301.
1991: Gerard J Mulder; Johan teKoppele; C G Schipper; W H Snel; K Sandy Pang; M Polhuijs
Stereoselectivity of glutathione conjugation in vivo, in the perfused liver and in isolated hepatocytes.
Drug metabolism reviews 1991;23(3-4):311-30.
1990: I A de Lannoy; H Hirayama; K Sandy Pang
A physiological model for renal drug metabolism: enalapril esterolysis to enalaprilat in the isolated perfused rat kidney.
Journal of pharmacokinetics and biopharmaceutics 1990;18(6):561-87.
1990: M V St-Pierre; D van den Berg; K Sandy Pang
Physiological modeling of drug and metabolite: disposition of oxazepam and oxazepam glucuronides in the recirculating perfused mouse liver preparation.
Journal of pharmacokinetics and biopharmaceutics 1990;18(5):423-48.
1990: N Xu; A Chow; CA Goresky; K Sandy Pang
Effects of retrograde flow on measured blood volume, Disse space, intracellular water space and drug extraction in the perfused rat liver: characterization by the multiple indicator dilution technique.
The Journal of pharmacology and experimental therapeutics 1990;254(3):914-25.
1990: H Hirayama; J Morgado; I Gasinska; K Sandy Pang
Estimations of intestinal and liver first-pass metabolism in vivo. Studies on gentisamide conjugation in the rat.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):588-94.
1990: H Hirayama; K Sandy Pang
First-pass metabolism of gentisamide: influence of intestinal metabolism on hepatic formation of conjugates. Studies in the once-through vascularly perfused rat intestine-liver preparation.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(5):580-7.
1990: K Sandy Pang; F Barker; Andreas Schwab; CA Goresky
[14C]urea and 58Co-EDTA as reference indicators in hepatic multiple indicator dilution studies.
The American journal of physiology 1990;259(1 Pt 1):G32-40.
1990: X Xu; Bing-Kou Tang; K Sandy Pang
Sequential metabolism of salicylamide exclusively to gentisamide 5-glucuronide and not gentisamide sulfate conjugates in single-pass in situ perfused rat liver.
The Journal of pharmacology and experimental therapeutics 1990;253(3):965-73.
1990: K Sandy Pang; Gerard J Mulder
The effect of hepatic blood flow on formation of metabolites.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(3):270-5.
1990: Andreas Schwab; F Barker; CA Goresky; K Sandy Pang
Transfer of enalaprilat across rat liver cell membranes is barrier limited.
The American journal of physiology 1990;258(3 Pt 1):G461-75.
1989: X Xu; K Sandy Pang
Hepatic modeling of metabolite kinetics in sequential and parallel pathways: salicylamide and gentisamide metabolism in perfused rat liver.
Journal of pharmacokinetics and biopharmaceutics 1989;17(6):645-71.
1989: I A de Lannoy; R Nespeca; K Sandy Pang
Renal handling of enalapril and enalaprilat: studies in the isolated red blood cell-perfused rat kidney.
The Journal of pharmacology and experimental therapeutics 1989;251(3):1211-22.
1989: X Xu; H Hirayama; K Sandy Pang
First-pass metabolism of salicylamide. Studies in the once-through vascularly perfused rat intestine-liver preparation.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(5):556-63.
1989: H Hirayama; X Xu; K Sandy Pang
Viability of the vascularly perfused, recirculating rat intestine and intestine-liver preparations.
The American journal of physiology 1989;257(2 Pt 1):G249-58.
1989: M V St-Pierre; Andreas Schwab; CA Goresky; W F Lee; K Sandy Pang
The multiple-indicator dilution technique for characterization of normal and retrograde flow in once-through rat liver perfusions.
Hepatology (Baltimore, Md.) 1989;9(2):285-96.
1988: M E Morris; V Yuen; K Sandy Pang
Competing pathways in drug metabolism. II. An identical, anterior enzymic distribution for 2- and 5-sulfoconjugation and a posterior localization for 5-glucuronidation of gentisamide in the rat liver.
Journal of pharmacokinetics and biopharmaceutics 1988;16(6):633-56.
1988: K Sandy Pang; W F Lee; W F Cherry; V Yuen; J Accaputo; S Fayz; Andreas Schwab; CA Goresky
Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: characterization by the multiple indicator dilution technique.
Journal of pharmacokinetics and biopharmaceutics 1988;16(6):595-632.
1988: K Sandy Pang; W F Cherry; J Accaputo; Andreas Schwab; CA Goresky
Combined hepatic arterial-portal venous and hepatic arterial-hepatic venous perfusions to probe the abundance of drug metabolizing activities: perihepatic venous O-deethylation activity for phenacetin and periportal sulfation activity for acetaminophen in the once-through rat liver preparation.
The Journal of pharmacology and experimental therapeutics 1988;247(2):690-700.
1988: M V St-Pierre; X Xu; K Sandy Pang
Primary, secondary, and tertiary metabolite kinetics.
Journal of pharmacokinetics and biopharmaceutics 1988;16(5):493-527.
1988: M E Morris; V Yuen; Bing-Kou Tang; K Sandy Pang
Competing pathways in drug metabolism. I. Effect of input concentration on the conjugation of gentisamide in the once-through in situ perfused rat liver preparation.
The Journal of pharmacology and experimental therapeutics 1988;245(2):614-24.
1987: M V St-Pierre; K Sandy Pang
Determination of diazepam and its metabolites by high-performance liquid chromatography and thin-layer chromatography.
Journal of chromatography 1987;421(2):291-307.
1987: M E Morris; K Sandy Pang
Competition between two enzymes for substrate removal in liver: modulating effects due to substrate recruitment of hepatocyte activity.
Journal of pharmacokinetics and biopharmaceutics 1987;15(5):473-96.
1987: Johan teKoppele; I A de Lannoy; K Sandy Pang; Gerard J Mulder
Stereoselective glutathione conjugation and amidase-catalyzed hydrolysis of alpha-bromoisovalerylurea enantiomers in isolated rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1987;243(1):349-55.
1987: X Xu; K Sandy Pang
High-performance liquid chromatographic method for the quantitation of salicylamide and its metabolites in biological fluids.
Journal of chromatography 1987;420(2):313-27.
1986: K Sandy Pang; V Yuen; S Fayz; Johan teKoppele; Gerard J Mulder
Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation.
Drug metabolism and disposition: the biological fate of chemicals 1986;14(1):102-11.
1984: L M Babiak; W F Cherry; S Fayz; K Sandy Pang
Kinetics of meperidine N-demethylation in the perfused rat liver preparation.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(6):698-704.
1984: K Sandy Pang; J C Huang; C Finkle; P Kong; W F Cherry; S Fayz
Kinetics of procainamide N-acetylation in the rat in vivo and in the perfused rat liver preparation.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(3):314-22.
1984: S Fayz; W F Cherry; J R Dawson; Gerard J Mulder; K Sandy Pang
Inhibition of acetaminophen sulfation by 2,6-dichloro-4-nitrophenol in the perfused rat liver preparation. Lack of a compensatory increase of glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals 1984;12(3):323-9.