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Yuan-Ping Pang
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16
Han, Yi-Fan
14
Carlier, Paul
7
Brimijoin, Stephen
5
Li, Zhi-Wang
4
Silman, Israel
4
Sussman, Joel
4
Wang, Hui
4
Kollmeyer, Thomas
3
Wong, Dawn
3
Yu, Hua
3
Lockridge, Oksana
3
Lee, Nelson
3
Li, CP
3
Li, Wen-Ming
3
El Yazal, J
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All Publications
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2009: Zhou Li; Liu Yu-Wei; Peoples Robert W; Yang Min; Tian Xiang; Ai Yong-Xun; Pang Yuan-Ping; Li Zhi-Wang; Han Yi-Fan; Li Chao-Ying
Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons.
Neuropharmacology 2009;57(1):33-40.
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2009: Pang Yuan-Ping; Vummenthala Anuradha; Mishra Rajesh K; Park Jewn Giew; Wang Shaohua; Davis Jon; Millard Charles B; Schmidt James J
Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design.
PloS one 2009;4(11):e7730.
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2009: Pang Yuan-Ping; Ekström Fredrik; Polsinelli Gregory A; Gao Yang; Rana Sandeep; Hua Duy H; Andersson Björn; Andersson Per Ola; Peng Lei; Singh Sanjay K; Mishra Rajesh K; Zhu Kun Yan; Fallon Ann M; Ragsdale David W; Brimijoin Stephen
Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases.
PloS one 2009;4(8):e6851.
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2009: Pang Yuan-Ping; Singh Sanjay K; Gao Yang; Lassiter T Leon; Mishra Rajesh K; Zhu Kun Yan; Brimijoin Stephen
Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides.
PloS one 2009;4(2):e4349.
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2008: Liu Yu-Wei; Luo Jia-Lie; Ren Hong; Peoples Robert W; Ai Yong-Xun; Liu Li-Jiang; Pang Yuan-Ping; Li Zhi-Wang; Han Yi-Fan; Li Chao-Ying
Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies.
Neuropharmacology 2008;54(7):1086-94.
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2008: Zhang Li; Yu Hua; Li Wen Ming; Cheung Man Chun; Pang Yuan Ping; Gu Ze Ming; Chan Kelvin; Wang Yi Tao; Zuo Zhong; Han Yi Fan
Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine.
International journal of pharmaceutics 2008;357(1-2):85-94.
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2008: Yu Hua; Li Wen-Ming; Kan Kelvin K W; Ho Jason M K; Carlier Paul R; Pang Yuan-Ping; Gu Zhe-Ming; Zhong Zuo; Chan Kelvin; Wang Yi-Tao; Han Yi-Fan
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.
Journal of pharmaceutical and biomedical analysis 2008;46(1):75-81.
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2007: Li W M; Kan K K W; Carlier P R; Pang Y P; Han Y F
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
Current Alzheimer research 2007;4(4):386-96.
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2007: Yu Hua; Ho Jason M K; Kan Kelvin K W; Cheng Bobby W H; Li Wen-Ming; Zhang Li; Lin Ge; Pang Yuan-Ping; Gu Zhe-Ming; Chan Kelvin; Wang Yi-Tao; Han Yi-Fan
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood.
Journal of pharmaceutical and biomedical analysis 2007;44(5):1133-8.
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2007: Nie Hui; Yu Wen-Jing; Li Xiang-Yuan; Yuan Chun-Hua; Pang Yuan-Ping; Li Chao-Ying; Han Yi-Fan; Li Zhi-Wang
Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels.
Neuroscience letters 2007;412(2):108-13.
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2006: Rydberg Edwin H; Brumshtein Boris; Greenblatt Harry M; Wong Dawn M; Shaya David; Williams Larry D; Carlier Paul R; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Journal of medicinal chemistry 2006;49(18):5491-500.
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2005: Haviv Haim; Wong Dawn M; Greenblatt Harry M; Carlier Paul R; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.
Journal of the American Chemical Society 2005;127(31):11029-36.
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2004: Luo Jia-Lie; Zhang Jian; Guan Bing-Cai; Pang Yuan-Ping; Han Yi-Fan; Li Zhi-Wang
Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons.
Neuroreport 2004;15(8):1335-8.
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2003: Hammond P I; Kern C; Hong F; Kollmeyer T M; Pang Y-P; Brimijoin S
Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design.
The Journal of pharmacology and experimental therapeutics 2003;307(1):190-6.
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2003: Pang Yuan-Ping; Kumar Ganesh A; Zhang Jin-San; Urrutia Raul
Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A.
FEBS letters 2003;548(1-3):108-12.
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2003: Pang Yuan-Ping; Kollmeyer Thomas M; Hong Feng; Lee Jong-Cheol; Hammond Pamela I; Haugabouk Sharie P; Brimijoin Stephen
Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators.
Chemistry & biology 2003;10(6):491-502.
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2003: Wong Dawn M; Greenblatt Harry M; Dvir Hay; Carlier Paul R; Han Yi-Fan; Pang Yuan-Ping; Silman Israel; Sussman Joel L
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
Journal of the American Chemical Society 2003;125(2):363-73.
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2002: Sun Hong; Shen Maryann L; Pang Yuan-Ping; Lockridge Oksana; Brimijoin Stephen
Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase.
The Journal of pharmacology and experimental therapeutics 2002;302(2):710-6.
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2002: Sun Hong; Pang Yuan-Ping; Lockridge Oksana; Brimijoin Stephen
Re-engineering butyrylcholinesterase as a cocaine hydrolase.
Molecular pharmacology 2002;62(2):220-4.
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2002: Pan S Y; Han Y F; Carlier P R; Pang Y P; Mak D H F; Lam B Y H; Ko K M
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.
Planta medica 2002;68(3):217-20.
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2001: Pang Y P; Xu K; Kollmeyer T M; Perola E; McGrath W J; Green D T; Mangel W F
Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases.
FEBS letters 2001;502(3):93-7.
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2001: Sun H; El Yazal J; Lockridge O; Schopfer L M; Brimijoin S; Pang Y P
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
The Journal of biological chemistry 2001;276(12):9330-6.
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2000: Pang Y P; Xu K; Yazal J E; Prendergas F G
Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach.
Protein science : a publication of the Protein Society 2000;9(10):1857-65.
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2000: Wu D C; Xiao X Q; Ng A K; Chen P M; Chung W; Lee N T; Carlier P R; Pang Y P; Yu A C; Han Y F;
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].
Neuroscience letters 2000;288(2):95-8.
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2000: Perola E; Xu K; Kollmeyer T M; Kaufmann S H; Prendergast F G; Pang Y P
Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads.
Journal of medicinal chemistry 2000;43(3):401-8.
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1999: Han Y F; Li C P; Chow E; Wang H; Pang Y P; Carlier P R
Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.
Bioorganic & medicinal chemistry 1999;7(11):2569-75.
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1999: Carlier P R; Chow E S; Han Y; Liu J; El Yazal J; Pang Y P
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.
Journal of medicinal chemistry 1999;42(20):4225-31.
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1999: Carlier P R; Du D M; Han Y; Liu J; Pang Y P
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(16):2335-8.
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1999: Marszalek P E; Pang Y P; Li H; El Yazal J; Oberhauser A F; Fernandez J M
Atomic levers control pyranose ring conformations.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7894-8.
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1999: Wang H; Carlier P R; Ho W L; Lee N T; Pang Y P; Han Y F
Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(3):211-7.
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1999: Li C Y; Wang H; Xue H; Carlier P R; Hui K M; Pang Y P; Li Z W; Han Y F
Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist.
Neuroreport 1999;10(4):795-800.
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1999: Wang H; Carlier P R; Ho W L; Wu D C; Lee N T; Li C P; Pang Y P; Han Y F
Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE.
Neuroreport 1999;10(4):789-93.
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1999: Carlier P R; Han Y F; Chow E S; Li C P; Wang H; Lieu T X; Wong H S; Pang Y P
Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.
Bioorganic & medicinal chemistry 1999;7(2):351-7.
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1998: Marszalek P E; Oberhauser A F; Pang Y P; Fernandez J M
Polysaccharide elasticity governed by chair-boat transitions of the glucopyranose ring.
Nature 1998;396(6712):661-4.
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1997: Raves M L; Harel M; Pang Y P; Silman I; Kozikowski A P; Sussman J L
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nature structural biology 1997;4(1):57-63.
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