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Yuan-Ping Pang

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Alzheimer's Disease

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Myoung Shin Kim; Yuka Machida; Yuan-Ping Pang; Ajay A Vashisht; James A Wohlschlegel; Yuichi J Machida
Regulation of error-prone translesion synthesis by Spartan/C1orf124.
Dengfeng Dou; Haobo Jiang; Benjamin J Madden; Jewn Giew Park; Sandeep Rana; Yuan-Ping Pang
Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases.
Yuan-Ping Pang; David W Ragsdale; Stephen Brimijoin; Kun Yan Zhu; Robert Suranyi
Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides.

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All Publications

2013: Myoung Shin Kim; Yuka Machida; Yuan-Ping Pang; Ajay A Vashisht; James A Wohlschlegel; Yuichi J Machida
Regulation of error-prone translesion synthesis by Spartan/C1orf124.
Nucleic acids research 2013;41(3):1661-8.
2013: Dengfeng Dou; Haobo Jiang; Benjamin J Madden; Jewn Giew Park; Sandeep Rana; Yuan-Ping Pang
Novel selective and irreversible mosquito acetylcholinesterase inhibitors for controlling malaria and other mosquito-borne diseases.
Scientific reports 2013;3():1068.
2012: Yuan-Ping Pang; David W Ragsdale; Stephen Brimijoin; Kun Yan Zhu; Robert Suranyi
Novel and viable acetylcholinesterase target site for developing effective and environmentally safe insecticides.
Current drug targets 2012;13(4):471-82.
2012: Jewn Giew Park; Nilgun E Tumer; Jennifer Nielsen Kahn; Yuan-Ping Pang
Chemical structure of Retro-2, a compound that protects cells against ribosome-inactivating proteins.
Scientific reports 2012;2():631.
2011: Yuan-Ping Pang; Jewn Giew Park; Shaohua Wang; Anuradha Vummenthala; Rajesh K Mishra; John E McLaughlin; Rong Di; Jennifer Nielsen Kahn; Nilgun E Tumer; Laszlo Janosi; Jon Davis; Charles B Millard
Small-molecule inhibitor leads of ribosome-inactivating proteins developed using the doorstop approach.
PloS one 2011;6(3):e17883.
2010: Gregory A Polsinelli; Sanjay K Singh; Rajesh K Mishra; Robert Suranyi; David W Ragsdale; Yuan-Ping Pang; Stephen Brimijoin
Insect-specific irreversible inhibitors of acetylcholinesterase in pests including the bed bug, the eastern yellowjacket, German and American cockroaches, and the confused flour beetle.
Chemico-biological interactions 2010;187(1-3):142-7.
2010: Yuan-Ping Pang; Jon Davis; Shaohua Wang; Jewn Giew Park; Madhusoodana P Nambiar; James J Schmidt; Charles B Millard
Small molecules showing significant protection of mice against botulinum neurotoxin serotype A.
PloS one 2010;5(4):e10129.
2009: Li Zhou; Yu-Wei Liu; Robert W Peoples; Min Yang; Xiang Tian; Yong-Xun Ai; Yuan-Ping Pang; Zhi-Wang Li; Yi-Fan Han; Chao-Ying Li
Mechanism of bis(7)-tacrine inhibition of GABA-activated current in cultured rat hippocampal neurons.
Neuropharmacology 2009;57(1):33-40.
2009: Yuan-Ping Pang; Anuradha Vummenthala; Rajesh K Mishra; Jewn Giew Park; Shaohua Wang; Jon Davis; Charles B Millard; James J Schmidt
Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design.
PloS one 2009;4(11):e7730.
2009: Yuan-Ping Pang; Fredrik Ekström; Gregory Polsinelli; Yang Gao; Sandeep Rana; Duy H Hua; Björn Andersson; Per Ola Andersson; Lei Peng; Sanjay K Singh; Rajesh K Mishra; Kun Yan Zhu; Ann M Fallon; David W Ragsdale; Stephen Brimijoin
Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases.
PloS one 2009;4(8):e6851.
2009: Yuan-Ping Pang; Sanjay K Singh; Yang Gao; T Leon Lassiter; Rajesh K Mishra; Kun Yan Zhu; Stephen Brimijoin
Selective and irreversible inhibitors of aphid acetylcholinesterases: steps toward human-safe insecticides.
PloS one 2009;4(2):e4349.
2008: Li Zhang; Hua Yu; Wen Ming Li; Man Chun Cheung; Yuan-Ping Pang; Ze Ming Gu; Kelvin Chan; Yi Tao Wang; Zhong Zuo; Yi-Fan Han
Preclinical characterization of intestinal absorption and metabolism of promising anti-Alzheimer's dimer bis(7)-tacrine.
International journal of pharmaceutics 2008;357(1-2):85-94.
2008: Yu-Wei Liu; Jia-Lie Luo; Hong Ren; Robert W Peoples; Yong-Xun Ai; Li-Jiang Liu; Yuan-Ping Pang; Zhi-Wang Li; Yi-Fan Han; Chao-Ying Li
Inhibition of NMDA-gated ion channels by bis(7)-tacrine: whole-cell and single-channel studies.
Neuropharmacology 2008;54(7):1086-94.
2008: Hua Yu; Wen-Ming Li; Kelvin K W Kan; Jason M K Ho; Paul R Carlier; Yuan-Ping Pang; Zhe-Ming Gu; Zuo Zhong; Kelvin Chan; Yi-Tao Wang; Yi-Fan Han
The physicochemical properties and the in vivo AChE inhibition of two potential anti-Alzheimer agents, bis(12)-hupyridone and bis(7)-tacrine.
Journal of pharmaceutical and biomedical analysis 2008;46(1):75-81.
2007: Hua Yu; Jason M K Ho; Kelvin K W Kan; Bobby W H Cheng; Wen-Ming Li; Li Zhang; Ge Lin; Yuan-Ping Pang; Zhe-Ming Gu; Kelvin Chan; Yi-Tao Wang; Yi-Fan Han
Development of a high performance liquid chromatography-tandem mass method for determination of bis(7)-tacrine, a promising anti-Alzheimer's dimer, in rat blood.
Journal of pharmaceutical and biomedical analysis 2007;44(5):1133-8.
2007: Wen-Ming Li; Kelvin K W Kan; Paul R Carlier; Yuan-Ping Pang; Yi-Fan Han
East meets West in the search for Alzheimer's therapeutics - novel dimeric inhibitors from tacrine and huperzine A.
Current Alzheimer research 2007;4(4):386-96.
2007: Hui Nie; Wen-Jing Yu; Xiang-Yuan Li; Chun-Hua Yuan; Yuan-Ping Pang; Chao-Ying Li; Yi-Fan Han; Zhi-Wang Li
Inhibition by bis(7)-tacrine of native delayed rectifier and KV1.2 encoded potassium channels.
Neuroscience letters 2007;412(2):108-13.
2006: Edwin H Rydberg; Boris Brumshtein; Harry M Greenblatt; Dawn M Wong; David Shaya; Larry D Williams; Paul R Carlier; Yuan-Ping Pang; Israel Silman; Joel Sussman
Complexes of alkylene-linked tacrine dimers with Torpedo californica acetylcholinesterase: Binding of Bis5-tacrine produces a dramatic rearrangement in the active-site gorge.
Journal of medicinal chemistry 2006;49(18):5491-500.
2005: Haim Haviv; Dawn M Wong; Harry M Greenblatt; Paul R Carlier; Yuan-Ping Pang; Israel Silman; Joel Sussman
Crystal packing mediates enantioselective ligand recognition at the peripheral site of acetylcholinesterase.
Journal of the American Chemical Society 2005;127(31):11029-36.
2004: Jia-Lie Luo; Jian Zhang; Bing-Cai Guan; Yuan-Ping Pang; Yi-Fan Han; Zhi-Wang Li
Inhibition by bis(7)-tacrine of 5-HT-activated current in rat TG neurons.
Neuroreport 2004;15(8):1335-8.
2004: Jewn Giew Park; Kevin J Langenwalter; Carolyn A Weinbaum; Patrick J Casey; Yuan-Ping Pang
Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors.
Journal of combinatorial chemistry 2004;6(3):407-13.
2003: Pamela I Hammond; C Kern; F Hong; Thomas Kollmeyer; Yuan-Ping Pang; Stephen Brimijoin
Cholinesterase reactivation in vivo with a novel bis-oxime optimized by computer-aided design.
The Journal of pharmacology and experimental therapeutics 2003;307(1):190-6.
2003: Yuan-Ping Pang; Ganesh A Kumar; Jin-San Zhang; Raul Urrutia
Differential binding of Sin3 interacting repressor domains to the PAH2 domain of Sin3A.
FEBS letters 2003;548(1-3):108-12.
2003: Yuan-Ping Pang; Thomas Kollmeyer; Feng Hong; Jong-Cheol Lee; Pamela I Hammond; Sharie P Haugabouk; Stephen Brimijoin
Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators.
Chemistry & biology 2003;10(6):491-502.
2003: Dawn M Wong; Harry M Greenblatt; Hay Dvir; Paul R Carlier; Yi-Fan Han; Yuan-Ping Pang; Israel Silman; Joel Sussman
Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity.
Journal of the American Chemical Society 2003;125(2):363-73.
2002: Hong Sun; Maryann L Shen; Yuan-Ping Pang; Oksana Lockridge; Stephen Brimijoin
Cocaine metabolism accelerated by a re-engineered human butyrylcholinesterase.
The Journal of pharmacology and experimental therapeutics 2002;302(2):710-6.
2002: Hong Sun; Yuan-Ping Pang; Oksana Lockridge; Stephen Brimijoin
Re-engineering butyrylcholinesterase as a cocaine hydrolase.
Molecular pharmacology 2002;62(2):220-4.
2002: Si-Yuan Pan; Yi-Fan Han; Paul R Carlier; Yuan-Ping Pang; Duncan H F Mak; B Y H Lam; Kam Ming Ko
Schisandrin B protects against tacrine- and bis(7)-tacrine-induced hepatotoxicity and enhances cognitive function in mice.
Planta medica 2002;68(3):217-20.
2001: Yuan-Ping Pang; K Xu; Thomas Kollmeyer; E Perola; William J McGrath; D T Green; Walter F Mangel
Discovery of a new inhibitor lead of adenovirus proteinase: steps toward selective, irreversible inhibitors of cysteine proteinases.
FEBS letters 2001;502(3):93-7.
2001: H Sun; J El Yazal; Oksana Lockridge; Lawrence M Schopfer; Stephen Brimijoin; Yuan-Ping Pang
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase. Engineering effective butyrylcholinesterase mutants for cocaine detoxication.
The Journal of biological chemistry 2001;276(12):9330-6.
2000: Yuan-Ping Pang; K Xu; J E Yazal; F G Prendergas
Successful molecular dynamics simulation of the zinc-bound farnesyltransferase using the cationic dummy atom approach.
Protein science : a publication of the Protein Society 2000;9(10):1857-65.
2000: DC Wu; Xiao Qiu Xiao; A K Ng; P M Chen; W Chung; Nelson T K Lee; Paul R Carlier; Yuan-Ping Pang; Albert Cheung Hoi Yu; Yi-Fan Han; D Wu; X Xiao; Y Pang; Y Han
Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected].
Neuroscience letters 2000;288(2):95-8.
2000: E Perola; K Xu; Thomas Kollmeyer; Scott H Kaufmann; F G Prendergast; Yuan-Ping Pang
Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads.
Journal of medicinal chemistry 2000;43(3):401-8.
1999: Yi-Fan Han; CP Li; E Chow; Hui Wang; Yuan-Ping Pang; Paul R Carlier
Dual-site binding of bivalent 4-aminopyridine- and 4-aminoquinoline-based AChE inhibitors: contribution of the hydrophobic alkylene tether to monomer and dimer affinities.
Bioorganic & medicinal chemistry 1999;7(11):2569-75.
1999: Paul R Carlier; Ella S-H Chow; Yifan Han; J Liu; J El Yazal; Yuan-Ping Pang
Heterodimeric tacrine-based acetylcholinesterase inhibitors: investigating ligand-peripheral site interactions.
Journal of medicinal chemistry 1999;42(20):4225-31.
1999: Paul R Carlier; Da-Ming Du; Yifan Han; J Liu; Yuan-Ping Pang
Potent, easily synthesized huperzine A-tacrine hybrid acetylcholinesterase inhibitors.
Bioorganic & medicinal chemistry letters 1999;9(16):2335-8.
1999: Piotr E Marszalek; Yuan-Ping Pang; H Li; J El Yazal; Andres Oberhauser; Julio M Fernandez
Atomic levers control pyranose ring conformations.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7894-8.
1999: C Y Li; H Wang; Hong Xue; Paul R Carlier; K M Hui; Yuan-Ping Pang; Zhi-Wang Li; Yi-Fan Han
Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist.
Neuroreport 1999;10(4):795-800.
1999: Hui Wang; Paul R Carlier; W L Ho; DC Wu; Nelson T K Lee; CP Li; Yuan-Ping Pang; Yi-Fan Han
Effects of bis(7)-tacrine, a novel anti-Alzheimer's agent, on rat brain AChE.
Neuroreport 1999;10(4):789-93.
1999: Hui Wang; Paul R Carlier; W L Ho; Nelson T K Lee; Yuan-Ping Pang; Yi-Fan Han
Attenuation of scopolamine-induced deficits in navigational memory performance in rats by bis(7)-tacrine, a novel dimeric AChE inhibitor.
Zhongguo yao li xue bao = Acta pharmacologica Sinica 1999;20(3):211-7.
1999: Paul R Carlier; Yi-Fan Han; Ella S-H Chow; CP Li; Hui Wang; T X Lieu; H S Wong; Yuan-Ping Pang
Evaluation of short-tether bis-THA AChE inhibitors. A further test of the dual binding site hypothesis.
Bioorganic & medicinal chemistry 1999;7(2):351-7.
1998: Piotr E Marszalek; Andres Oberhauser; Yuan-Ping Pang; Julio M Fernandez
Polysaccharide elasticity governed by chair-boat transitions of the glucopyranose ring.
Nature 1998;396(6712):661-4.
1997: Maria L Raves; Michal Harel; Yuan-Ping Pang; Israel Silman; Alan P Kozikowski; Joel Sussman
Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A.
Nature structural biology 1997;4(1):57-63.