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Christophe Pannecouque

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TOP 3
Dongyue Li; Huiqing Liu; Jan Balzarini; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Xinyong Liu
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.
Mikhail S Novikov; Christophe Pannecouque; Maria P Paramonova; Graciela Andrei; Denis A Babkov; Jan Balzarini; Sergey A Gavryushov; Alexander V Ivanov; Anastasiya Khandazhinskaya; Sergey N Kochetkov; Robert Snoeck; Vladimir T Valuev-Elliston; Katherine L Seley-Radtke
N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Rakesh Narang; Balasubramanian Narasimhan; Christophe Pannecouque; Sunil Sharma; Erik De Clercq; Jan Balzarini
Substituted naphthalen-1-yl-acetic acid hydrazides: synthesis, antimicrobial evaluation and QSAR analysis.

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All Publications

2013: Dongyue Li; Huiqing Liu; Jan Balzarini; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Xinyong Liu
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.
Bioorganic & medicinal chemistry 2013;21(7):2128-34.
2013: Mikhail S Novikov; Christophe Pannecouque; Maria P Paramonova; Graciela Andrei; Denis A Babkov; Jan Balzarini; Sergey A Gavryushov; Alexander V Ivanov; Anastasiya Khandazhinskaya; Sergey N Kochetkov; Robert Snoeck; Vladimir T Valuev-Elliston; Katherine L Seley-Radtke
N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorganic & medicinal chemistry 2013;21(5):1150-8.
2013: Rakesh Narang; Balasubramanian Narasimhan; Christophe Pannecouque; Sunil Sharma; Erik De Clercq; Jan Balzarini
Substituted naphthalen-1-yl-acetic acid hydrazides: synthesis, antimicrobial evaluation and QSAR analysis.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2013;9(2):249-74.
2013: Esra Tatar; TT Talele; Dirk Daelemans; Erik De Clercq; Neerja Kaushik-Basu; Ilkay Küçükgüzel; Christophe Pannecouque
Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1.
Archiv der Pharmazie 2013;346(2):140-53.
2013: Vikramjeet Judge; Balasubramanian Narasimhan; Christophe Pannecouque; Dharmarajan Sriram; Perumal Yogeeswari; Munish Ahuja; Erik De Clercq; Jan Balzarini
Synthesis, antimycobacterial, antiviral, antimicrobial activity and QSAR studies of N(2)-acyl isonicotinic acid hydrazide derivatives.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2013;9(1):53-76.
2012: Sergio R Ribone; Dirk Daelemans; Wim Dehaen; Volker Leen; Marcela Madrid; Christophe Pannecouque; Margarita C Briñón
Synthesis, biological evaluation and molecular modeling of 4,6-diarylpyrimidines and diarylbenzenes as novel non-nucleosides HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2012;58():485-92.
2012: Peng Zhan; Christophe Pannecouque; Ye Tian; Wenmin Chen; Xuwang Chen; Erik De Clercq; Xiao Li; Zhenyu Li; Xinyong Liu
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.
Bioorganic & medicinal chemistry 2012;20(23):6795-802.
2012: Peng Zhan; Wenmin Chen; Xuwang Chen; Xiao Li; Zhenyu Li; Xinyong Liu; Christophe Pannecouque; Ye Tian; Erik De Clercq
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.
Bioorganic & medicinal chemistry letters 2012;22(23):7155-62.
2012: Rahul P Modh; Christophe Pannecouque; Amit C Patel; Erik De Clercq; Dharmesh H Mahajan; Kishor H Chikhalia
Synthesis and evaluation of novel 4-substituted styryl quinazolines as potential antimicrobial agents.
Archiv der Pharmazie 2012;345(12):964-72.
2012: Rachel Smith; Erik De Clercq; Amy N Cain; Dirk Daelemans; TaRynn N Carder Freeman; Courtney D Garcia; Timothy J Hubin; Dana Huskens; Ryan E Mewis; Christophe Pannecouque; Dominique Schols; Stephen J Archibald
CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.
Dalton transactions (Cambridge, England : 2003) 2012;41(37):11369-77.
2012: Shiqiong Yang; Christophe Pannecouque; Piet Herdewijn
Synthesis, and in vitro enzymatic and antiviral evaluation of d4T polyphosphate derivatives as chain terminators.
Chemistry & biodiversity 2012;9(10):2186-94.
2012: Xiao Li; Hong Liu; Huiqing Liu; Christophe Pannecouque; Liu Wang; Peng Zhan; Erik De Clercq; Jan Balzarini; Xuwang Chen; Dongyue Li; Xinyong Liu
Arylazolyl(azinyl)thioacetanilides. Part 10: design, synthesis and biological evaluation of novel substituted imidazopyridinylthioacetanilides as potent HIV-1 inhibitors.
Bioorganic & medicinal chemistry 2012;20(18):5527-36.
2012: Asish K Bhattacharya; Christophe Pannecouque; Kalpeshkumar C Rana; Eric De Clercq
An efficient synthesis of a hydroxyethylamine (HEA) isostere and its α-aminophosphonate and phosphoramidate derivatives as potential anti-HIV agents.
ChemMedChem 2012;7(9):1601-11.
2012: Shuang-Xi Gu; Qiu-Qin He; Zhi-Ming Li; Xiao-Dong Ma; Jan Balzarini; Fen-Er Chen; Erik De Clercq; Shi-Qiong Yang; Christophe Pannecouque
Chiral resolution, absolute configuration assignment and biological activity of racemic diarylpyrimidine CH(OH)-DAPY as potent nonnucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2012;53():229-34.
2012: Xuwang Chen; Ziheng Cheng; Xin Liu; Caicai Meng; Christophe Pannecouque; Siyuan Shao; Peng Zhan; Erik De Clercq; Xinyong Liu
Design, synthesis, anti-HIV evaluation and molecular modeling of piperidine-linked amino-triazine derivatives as potent non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2012;20(12):3856-64.
2012: Allison Ross; Jong-Ha Choi; Erik De Clercq; Tina M Hunter; Stephen A Moggach; Christophe Pannecouque; Simon Parsons; Peter J Sadler
Zinc(II) complexes of constrained antiviral macrocycles.
Dalton transactions (Cambridge, England : 2003) 2012;41(21):6408-18.
2012: Peng Zhan; Qiangqiang Zhang; Xuwang Chen; Erik De Clercq; Xin Jiang; Xiao Li; Ailin Liu; Hong Liu; Xinyong Liu; Lieve Naesens; Christophe Pannecouque; Liu Wang; Guanhua Du
Arylazolyl(azinyl)thioacetanilide. Part 9: Synthesis and biological investigation of thiazolylthioacetamides derivatives as a novel class of potential antiviral agents.
Archives of pharmacal research 2012;35(6):975-86.
2012: Rahul V Patel; Dhanji P Rajani; Erik De Clercq; Premlata Kumari; Christophe Pannecouque; Kishor H Chikhalia
Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of new s-triazine-based heterocycles.
Future medicinal chemistry 2012;4(9):1053-65.
2012: Xuwang Chen; Erik De Clercq; Christophe Pannecouque; Peng Zhan; Jan Balzarini; Xinyong Liu
Synthesis and biological evaluation of piperidine-substituted triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors.
European journal of medicinal chemistry 2012;51():60-6.
2012: Wenjun Li; Yu Chang; Erik De Clercq; Christophe Pannecouque; Jingde Wu; Peng Zhan; Xinyong Liu
Synthesis, drug release and anti-HIV activity of a series of PEGylated zidovudine conjugates.
International journal of biological macromolecules 2012;50(4):974-80.
2012: Shiqiong Yang; Anne Giraut; Eveline Lescrinier; Christophe Pannecouque; Piet Herdewijn
Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators.
Organic & biomolecular chemistry 2012;10(1):146-53.
2012: Thomas Vercruysse; Jan Balzarini; Beata Basta; François Debaene; Wim Dehaen; Nicolas Humbert; Yves Mély; Christophe Pannecouque; Sarah Sanglier-Cianférani; Dirk Daelemans
A phenyl-thiadiazolylidene-amine derivative ejects zinc from retroviral nucleocapsid zinc fingers and inactivates HIV virions.
Retrovirology 2012;9():95.
2012: Britta Moens; Christophe Pannecouque; Michael Talledo; Achiléa Bittencourt; Lourdes Farré; Bernardo Galvão-Castro; Eduardo Gotuzzo; Ricardo Khouri; Giovanni López; Anne-Mieke Vandamme; Johan Van Weyenbergh
Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines.
Virology journal 2012;9():171.
2011: Xiao-Dong Ma; Shi-Qiong Yang; Jan Balzarini; Fen-Er Chen; Erik De Clercq; Shuang-Xi Gu; Qiu-Qin He; Christophe Pannecouque
Synthesis and anti-HIV activity of aryl-2-[(4-cyanophenyl)amino]-4-pyrimidinone hydrazones as potent non-nucleoside reverse transcriptase inhibitors.
ChemMedChem 2011;6(12):2225-32.
2011: P Zhan; Myriam Witvrouw; R Z Yan; Erik De Clercq; X Y Liu; M T Molina; Christophe Pannecouque; S Vega
Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives.
Drug discoveries & therapeutics 2011;5(6):279-85.
2011: Shuang-Xi Gu; Qiu-Qin He; Xiao-Dong Ma; Jan Balzarini; Fen-Er Chen; Erik De Clercq; Hui-Fang Dai; Shi-Qiong Yang; Christophe Pannecouque
Design, synthesis and biological evaluation of cycloalkyl arylpyrimidines (CAPYs) as HIV-1 NNRTIs.
Bioorganic & medicinal chemistry 2011;19(23):7093-9.
2011: Mikhail S Novikov; Alexander A Ozerov; Christophe Pannecouque; Jan Balzarini; Galina V Gurskaya; Alexander V Ivanov; Olga N Ivanova; Sergey N Kochetkov; Kartik Temburnikar; Vladimir T Valuev-Elliston; Katherine L Seley-Radtke
1-[2-(2-Benzoyl- and 2-benzylphenoxy)ethyl]uracils as potent anti-HIV-1 agents.
Bioorganic & medicinal chemistry 2011;19(19):5794-802.
2011: Peng Zhan; Christophe Pannecouque; Ye Tian; Wenwen Chen; Xuwang Chen; Erik De Clercq; Dongyue Li; Xiao Li; Xinyong Liu
Arylazolylthioacetanilide. Part 8: Design, synthesis and biological evaluation of novel 2-(2-(2,4-dichlorophenyl)-2H-1,2,4-triazol-3-ylthio)-N-arylacetamides as potent HIV-1 inhibitors.
European journal of medicinal chemistry 2011;46(10):5039-45.
2011: Shuang-Xi Gu; Qiu-Qin He; Xiao-Dong Ma; Jan Balzarini; Fen-Er Chen; Shi-Qiong Yang; Erik De Clercq; Christophe Pannecouque
Synthesis and structure-activity relationship of novel diarylpyrimidines with hydromethyl linker (CH(OH)-DAPYs) as HIV-1 NNRTIs.
Bioorganic & medicinal chemistry 2011;19(17):5117-24.
2011: Irene Lagoja; Christophe Pannecouque; Veronica Maria Rojasdelaparra; Gerard Griffioen; Stefaan Wera; Arthur Van Aerschot
Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2011;43(5):386-92.
2011: Jing Zhang; Christophe Pannecouque; Jingde Wu; Peng Zhan; Erik De Clercq; Weiying Ge; Yan Jiang; Zhenyu Li; Xinyong Liu
Synthesis and biological evaluation of novel 5-alkyl-2-arylthio-6-((3,4-dihydroquinolin-1(2H)-yl)methyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2011;19(14):4366-76.
2011: Oriana Tabarrini; Stefano Sabatini; Luca Sancineto; Violetta Cecchetti; Dirk Daelemans; Giuseppe Manfroni; Serena Massari; Christophe Pannecouque
Structural investigation of the naphthyridone scaffold: identification of a 1,6-naphthyridone derivative with potent and selective anti-HIV activity.
ChemMedChem 2011;6(7):1249-57.
2011: Dirk Daelemans; Rudi Pauwels; Erik De Clercq; Christophe Pannecouque
A time-of-drug addition approach to target identification of antiviral compounds.
Nature protocols 2011;6(6):925-33.
2011: Mingyan Yu; Zhenyu Li; Shuai Liu; Erkang Fan; Christophe Pannecouque; Erik De Clercq; Xinyong Liu
Synthesis and biological evaluation of 6-substituted 5-alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.
ChemMedChem 2011;6(5):826-33.
2011: Mohamed A Ali; Tan S Choon; Eric De Clercq; RUSLI ISMAIL; Suresh Pandian; Jeyabalan G Samy; Ang C Wei; Yeong K Yoon; Christophe Pannecouque
Synthesis and anti-HIV activity of novel 3-substituted phenyl-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]isoxazole analogues.
Acta poloniae pharmaceutica 2011;68(3):343-8.
2011: Vaibhav P Mehta; Sachin G Modha; Eelco Ruijter; Kristof Van Hecke; Luc Van Meervelt; Christophe Pannecouque; Jan Balzarini; Romano V A Orru; Erik Van Der Eycken
A microwave-assisted diastereoselective multicomponent reaction to access dibenzo[c,e]azepinones: synthesis and biological evaluation.
The Journal of organic chemistry 2011;76(8):2828-39.
2011: Giuseppe La Regina; Antonio Coluccia; Andrea Brancale; Francesco Piscitelli; Valerio Gatti; giovanni maga; Alberta Samuele; Christophe Pannecouque; Dominique Schols; Jan Balzarini; Ettore Novellino; Romano Silvestri
Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.
Journal of medicinal chemistry 2011;54(6):1587-98.
2011: Thomas Vercruysse; Sonalika Pawar; Wim De Borggraeve; Els Pardon; George Pavlakis; Christophe Pannecouque; Jan Steyaert; Jan Balzarini; Dirk Daelemans
Measuring cooperative Rev protein-protein interactions on Rev responsive RNA by fluorescence resonance energy transfer.
RNA biology 2011;8(2):316-24.
2011: Katarzyna Kulik; Ewa Radzikowska; Renata Kaczmarek; Janina Baraniak; Wojciech J Stec; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates.
Antiviral chemistry & chemotherapy 2011;21(3):143-50.
2010: Hanane Elayadi; Michael Smietana; Christophe Pannecouque; Pieter Leyssen; Johan Neyts; Jean-Jacques Vasseur; Hassan B Lazrek
Straightforward synthesis of triazoloacyclonucleotide phosphonates as potential HCV inhibitors.
Bioorganic & medicinal chemistry letters 2010;20(24):7365-8.
2010: Snehlata Yadav; Pradeep Kumar; Erik De Clercq; Jan Balzarini; Christophe Pannecouque; Sharwan Kumar Dewan; Balasubramanian Narasimhan
4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.
European journal of medicinal chemistry 2010;45(12):5985-97.
2010: Wenjun Li; Yu Chang; Peng Zhan; Na Zhang; Xinyong Liu; Christophe Pannecouque; Erik De Clercq
Synthesis, in vitro and in vivo release kinetics, and anti-HIV activity of a sustained-release prodrug (mPEG-AZT) of 3'-azido-3'-deoxythymidine (AZT, Zidovudine).
ChemMedChem 2010;5(11):1893-8.
2010: Oriana Tabarrini; Serena Massari; Dirk Daelemans; Francesco Meschini; Giuseppe Manfroni; Laura Bottega; Barbara Gatto; Manlio Palumbo; Christophe Pannecouque; Violetta Cecchetti
Studies of anti-HIV transcription inhibitor quinolones: identification of potent N1-vinyl derivatives.
ChemMedChem 2010;5(11):1880-92.
2010: Gilles Casano; Aurélien Dumètre; Christophe Pannecouque; Sébastien Hutter; Nadine Azas; Maxime Robin
Anti-HIV and antiplasmodial activity of original flavonoid derivatives.
Bioorganic & medicinal chemistry 2010;18(16):6012-23.
2010: Zhao-Sen Zeng; Qiu-Qin He; Yong-Hong Liang; Xiao-Qing Feng; Fen-Er Chen; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Hybrid diarylbenzopyrimidine non-nucleoside reverse transcriptase inhibitors as promising new leads for improved anti-HIV-1 chemotherapy.
Bioorganic & medicinal chemistry 2010;18(14):5039-47.
2010: Peng Zhan; Xin-Yong Liu; Zhen-Yu Li; Zeng-Jun Fang; Christophe Pannecouque; Erik De Clercq
1,2,3-thiadiazole thioacetanilides. Part 2: Synthesis and biological evaluation of a new series of 2-{[4-(3,4-dichlorophenyl)-1,2,3-thiadiazol-5-yl]sulfanyl}acetanilides as HIV-1 inhibitors.
Chemistry & biodiversity 2010;7(7):1717-27.
2010: Yong-Hong Liang; Qiu-Qin He; Zhao-Sen Zeng; Zhi-Qian Liu; Xiao-Qing Feng; Fen-Er Chen; Jan Balzarini; Christophe Pannecouque; Erik De Clercq
Synthesis and anti-HIV activity of 2-naphthyl substituted DAPY analogues as non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2010;18(13):4601-5.
2010: Sheila M Maregesi; Nina Hermans; Liene Dhooghe; Kanyanga Cimanga; Daneel Ferreira; Christophe Pannecouque; Dirk Vanden Berghe; Paul Cos; Louis Maes; Arnold Vlietinck; Sandra Apers; Luc Pieters
Phytochemical and biological investigations of Elaeodendron schlechteranum.
Journal of ethnopharmacology 2010;129(3):319-26.
2010: Zhao-Sen Zeng; Yong-Hong Liang; Xiao-Qing Feng; Fen-Er Chen; Christophe Pannecouque; Jan Balzarini; Erik De Clercq
Lead optimization of diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
ChemMedChem 2010;5(6):837-40.
2010: A Meli Lannang; Gabin Nselapi Louh; Bernadette Messi Biloa; Justin Komguem; Celine Djama Mbazoa; Beibam Lucas Sondengam; Lieve Naesens; Christophe Pannecouque; Erik De Clercq; El H Sayed El Ashry
Cytotoxicity of natural compounds isolated from the seeds of Garcinia afzelii.
Planta medica 2010;76(7):708-12.
2010: Xiao-Qing Feng; Zhao-Sen Zeng; Yong-Hong Liang; Fen-Er Chen; Christophe Pannecouque; Jan Balzarini; Erik De Clercq
Synthesis and biological evaluation of 4-(hydroxyimino)arylmethyl diarylpyrimidine analogues as potential non-nucleoside reverse transcriptase inhibitors against HIV.
Bioorganic & medicinal chemistry 2010;18(7):2370-4.
2010: Christophe Pannecouque; Beata Szafarowicz; Natalia Volkova; Vasiliy Bakulev; Wim Dehaen; Yves Mély; Dirk Daelemans
Inhibition of HIV-1 replication by a bis-thiadiazolbenzene-1,2-diamine that chelates zinc ions from retroviral nucleocapsid zinc fingers.
Antimicrobial agents and chemotherapy 2010;54(4):1461-8.
2010: Anna Maria Monforte; Patrizia Logoteta; Laura De Luca; Nunzio Iraci; Stefania Ferro; giovanni maga; Erik De Clercq; Christophe Pannecouque; Alba Chimirri
Novel 1,3-dihydro-benzimidazol-2-ones and their analogues as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2010;18(4):1702-10.
2010: Allison Ross; Dinesh C Soares; Danielle Covelli; Christophe Pannecouque; Laura Budd; Anna Collins; Neil Robertson; Simon Parsons; Erik De Clercq; Pierre Kennepohl; Peter J Sadler
Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists.
Inorganic chemistry 2010;49(3):1122-32.
2010: Dirk Daelemans; Jean-Maurice Dumont; Brigitte Rosenwirth; Erik De Clercq; Christophe Pannecouque
Debio-025 inhibits HIV-1 by interfering with an early event in the replication cycle.
Antiviral research 2010;85(2):418-21.
2010: Sheila Maregesi; Sabine van Miert; Christophe Pannecouque; Mohammed H Feiz Haddad; Nina Hermans; Colin W Wright; Arnold Vlietinck; Sandra Apers; Luc Pieters
Screening of Tanzanian medicinal plants against Plasmodium falciparum and human immunodeficiency virus.
Planta medica 2010;76(2):195-201.
2010: Serena Massari; Dirk Daelemans; Maria Letizia Barreca; Anna Knezevich; Stefano Sabatini; Violetta Cecchetti; Alessandro Marcello; Christophe Pannecouque; Oriana Tabarrini
A 1,8-naphthyridone derivative targets the HIV-1 Tat-mediated transcription and potently inhibits the HIV-1 replication.
Journal of medicinal chemistry 2010;53(2):641-8.
2009: Mingyan Yu; Xinyong Liu; Zhenyu Li; Shuai Liu; Christophe Pannecouque; Erik De Clercq
Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.
Bioorganic & medicinal chemistry 2009;17(22):7749-54.
2009: Katrien O François; Christophe Pannecouque; Joeri Auwerx; Virginia Lozano; María-Jesús Pérez-Pérez; Dominique Schols; Jan Balzarini
The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential.
Antimicrobial agents and chemotherapy 2009;53(11):4852-9.
2009: Peng Zhan; Xinyong Liu; Zengjun Fang; Zhenyu Li; Christophe Pannecouque; Erik De Clercq
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2009;44(11):4648-53.
2009: Matthew D Cullen; William C Ho; Joseph D Bauman; Kalyan Das; Eddy Arnold; Tracy L Hartman; Karen M Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase.
Journal of medicinal chemistry 2009;52(20):6467-73.
2009: Albert Darque; Aurélien Dumètre; Sébastien Hutter; Gilles Casano; Maxime Robin; Christophe Pannecouque; Nadine Azas
Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates.
Bioorganic & medicinal chemistry letters 2009;19(20):5962-4.
2009: Peng Zhan; Xinyong Liu; Zengjun Fang; Christophe Pannecouque; Erik De Clercq
1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.
Bioorganic & medicinal chemistry 2009;17(17):6374-9.
2009: Yong-Hong Liang; Xiao-Qing Feng; Zhao-Sen Zeng; Fen-Er Chen; Jan Balzarini; Christophe Pannecouque; Erik De Clercq
Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
ChemMedChem 2009;4(9):1537-45.
2009: Osama I el-Sabbagh; Mohamed M Baraka; Samy M Ibrahim; Christophe Pannecouque; Graciela Andrei; Robert Snoeck; Jan Balzarini; Adel AHMED Rashad
Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
European journal of medicinal chemistry 2009;44(9):3746-53.
2009: Sevgi Karakuş; S Güniz Küçükgüzel; Ilkay Küçükgüzel; Erik De Clercq; Christophe Pannecouque; Graciela Andrei; Robert Snoeck; Fikrettin Sahin; omer faruk bayrak
Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
European journal of medicinal chemistry 2009;44(9):3591-5.
2009: Peng Zhan; Xinyong Liu; Junjie Zhu; Zengjun Fang; Zhenyu Li; Christophe Pannecouque; Erik De Clercq
Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2009;17(16):5775-81.
2009: Peng Zhan; Xinyong Liu; Zhenyu Li; Zengjun Fang; Zhong Li; Defeng Wang; Christophe Pannecouque; Erik De Clercq
Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.
Bioorganic & medicinal chemistry 2009;17(16):5920-7.
2009: Anna Maria Monforte; Patrizia Logoteta; Stefania Ferro; Laura De Luca; Nunzio Iraci; giovanni maga; Erik De Clercq; Christophe Pannecouque; Alba Chimirri
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.
Bioorganic & medicinal chemistry 2009;17(16):5962-7.
2009: Cledir R Santos; Rita Capela; Cláudia S G P Pereira; Emília Valente; Luís Gouveia; Christophe Pannecouque; Erik De Clercq; Rui Moreira; Paula Gomes
Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design.
European journal of medicinal chemistry 2009;44(6):2339-46.
2009: Dharmesh H Mahajan; Christophe Pannecouque; Erik De Clercq; Kishor H Chikhalia
Synthesis and studies of new 2-(coumarin-4-yloxy)-4,6-(substituted)-S-triazine derivatives as potential anti-HIV agents.
Archiv der Pharmazie 2009;342(5):281-90.
2009: Yuan-Zhen Xiong; Fen-Er Chen; Jan Balzarini; Erik De Clercq; Christophe Pannecouque
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain.
Chemistry & biodiversity 2009;6(4):561-8.
2009: Lieve Naesens; Evelien Vanderlinden; Erzsébet Roth; József Jeko; Graciela Andrei; Robert Snoeck; Christophe Pannecouque; Eszter Illyés; Gyula Batta; Pal Herczegh; Ferenc Sztaricskai
Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains.
Antiviral research 2009;82(1):89-94.
2009: Abid Khan; Gary Nicholson; John Greenman; Leigh Madden; Graeme McRobbie; Christophe Pannecouque; Erik De Clercq; Robert Ullom; Danny L Maples; Randall D Maples; Jon D Silversides; Timothy J Hubin; Stephen J Archibald
Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultrarigid metal complexes.
Journal of the American Chemical Society 2009;131(10):3416-7.
2009: Bo-Liang Deng; Yujie Zhao; Tracy L Hartman; Karen Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2009;44(3):1210-4.
2009: Yue-Ping Wang; Fen-Er Chen; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2009;44(3):1016-23.
2009: Yuan-Zhen Xiong; Hai-Rong Hu; Fen-Er Chen; Jan Balzarini; Christophe Pannecouque; Erik De Clercq
Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.
Yao xue xue bao = Acta pharmaceutica Sinica 2009;44(2):145-9.
2009: Xiao-Qing Feng; Yong-Hong Liang; Zhao-Sen Zeng; Fen-Er Chen; Jan Balzarini; Christophe Pannecouque; Erik De Clercq
Structural modifications of DAPY analogues with potent anti-HIV-1 activity.
ChemMedChem 2009;4(2):219-24.
2009: Ludovic Bannwarth; Thierry Rose; Laure Dufau; Régis Vanderesse; Julien Dumond; Brigitte Jamart-Grégoire; Christophe Pannecouque; Erik De Clercq; Michèle Reboud-Ravaux
Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases.
Biochemistry 2009;48(2):379-87.
2009: Serena Massari; Dirk Daelemans; Giuseppe Manfroni; Stefano Sabatini; Oriana Tabarrini; Christophe Pannecouque; Violetta Cecchetti
Studies on anti-HIV quinolones: new insights on the C-6 position.
Bioorganic & medicinal chemistry 2009;17(2):667-74.
2009: Peng Zhan; Xinyong Liu; Zhenyu Li; Christophe Pannecouque; Erik De Clercq
Design strategies of novel NNRTIs to overcome drug resistance.
Current medicinal chemistry 2009;16(29):3903-17.
2008: Ravindra K Rawal; Renu Tripathi; Seturam B Katti; Christophe Pannecouque; Erik De Clercq
Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
European journal of medicinal chemistry 2008;43(12):2800-6.
2008: Tine Van Neck; Christophe Pannecouque; Els Vanstreels; Miguel Stevens; Wim Dehaen; Dirk Daelemans
Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
Bioorganic & medicinal chemistry 2008;16(21):9487-97.
2008: Peng Zhan; Xinyong Liu; Yuan Cao; Yan Wang; Christophe Pannecouque; Erik De Clercq
1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(20):5368-71.
2008: Oriana Tabarrini; Serena Massari; Dirk Daelemans; Miguel Stevens; Giuseppe Manfroni; Stefano Sabatini; Jan Balzarini; Violetta Cecchetti; Christophe Pannecouque; Arnaldo Fravolini
Structure-activity relationship study on anti-HIV 6-desfluoroquinolones.
Journal of medicinal chemistry 2008;51(17):5454-8.
2008: Ravindra K Rawal; Renu Tripathi; Smitha Kulkarni; R Paranjape; Seturam B Katti; Christophe Pannecouque; Erik De Clercq
2-(2,6-Dihalo-phenyl)-3-heteroaryl-2-ylmethyl-1, 3-thiazolidin-4-ones: anti-HIV agents.
Chemical biology & drug design 2008;72(2):147-54.
2008: Anna Maria Monforte; Angela Rao; Patrizia Logoteta; Stefania Ferro; Laura De Luca; Maria Letizia Barreca; Nunzio Iraci; giovanni maga; Erik De Clercq; Christophe Pannecouque; Alba Chimirri
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2008;16(15):7429-35.
2008: Cledir Santos; José Morais; Luis Filipe Gouveia; Erik De Clercq; Christophe Pannecouque; Carsten Uhd Nielsen; Bente Steffansen; Rui Moreira; Paula Gomes
Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity.
ChemMedChem 2008;3(6):970-8.
2008: Yuan-Zhen Xiong; Fen-Er Chen; Jan Balzarini; Erik De Clercq; Christophe Pannecouque
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.
European journal of medicinal chemistry 2008;43(6):1230-6.
2008: Yaseen A Al-Soud; Najim A Al-Masoudi; Thilo Schuppler; Erik De Clercq; Christophe Pannecouque
Microwave-assisted synthesis and anti-HIV activity of new acyclic C-nucleosides of 3-(D-ribo-tetritol-1-yl)-5-mercapto-1,2,4-triazoles. Part 1.
Nucleosides, nucleotides & nucleic acids 2008;27(5):469-83.
2008: Cyrille Tomassi; Albert Nguyen Van Nhien; José Marco-Contelles; Jan Balzarini; Christophe Pannecouque; Erik De Clercq; Denis Postel
Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.
Bioorganic & medicinal chemistry 2008;16(8):4733-41.
2008: Cyrille Tomassi; Van Nhien Albert Nguyen; José Marco-Contelles; Jan Balzarini; Christophe Pannecouque; Erik De Clercq; Elena Soriano; Denis Postel
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.
Bioorganic & medicinal chemistry letters 2008;18(7):2277-81.
2008: Yue-Ping Wang; Fen-Er Chen; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2008;16(7):3887-94.
2008: Xin-yong Liu; Ren-zhang Yan; Yan Wang; Peng Zhan; Erik De Clercq; Christophe Pannecouque; Myriam Witvrouw; Maria Teresa Molina; Salvador Vega
Synthesis and anti-HIV activity evaluation of novel 2,4-disubstituted 7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo-[4,5-e][1,2]thiadiazines.
Archiv der Pharmazie 2008;341(4):216-22.
2008: Matthew D Cullen; York-Fong Cheung; Miles D Houslay; Tracy L Hartman; Karen M Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(4):1530-3.
2008: Matthew D Cullen; Taradas Sarkar; Ernest Hamel; Tracy L Hartman; Karen M Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Inhibition of tubulin polymerization by select alkenyldiarylmethanes.
Bioorganic & medicinal chemistry letters 2008;18(2):469-73.
2008: Christophe Pannecouque; Dirk Daelemans; Erik De Clercq
Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later.
Nature protocols 2008;3(3):427-34.
2008: Yueping Wang; Fen-Er Chen; Jan Balzarini; Erik De Clercq; Christophe Pannecouque
Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10. Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues.
Chemistry & biodiversity 2008;5(1):168-76.
2008: Yongqiang Lin; Xinyong Liu; Renzhang Yan; Jin Li; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs).
Bioorganic & medicinal chemistry 2008;16(1):157-63.
2007: Yaseen A Al-Soud; Najim A Al-Masoudi; Hamed Gh Hassan; Erik De Clercq; Christophe Pannecouque
Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives.
Acta pharmaceutica (Zagreb, Croatia) 2007;57(4):379-93.
2007: Graeme McRobbie; Gina C Valks; Christopher J Empson; Abid Khan; Jon D Silversides; Christophe Pannecouque; Erik De Clercq; Steven G Fiddy; Adam J Bridgeman; Nigel A Young; Stephen J Archibald
Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists.
Dalton transactions (Cambridge, England : 2003) 2007;(43):5008-18.
2007: Matthew D Cullen; Bo-Liang Deng; Tracy L Hartman; Karen M Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability.
Journal of medicinal chemistry 2007;50(20):4854-67.
2007: Kristel Van Laethem; Christophe Pannecouque; Anne-Mieke Vandamme
Mutations at 65 and 70 within the context of a Q151M cluster in human immunodeficiency virus type 1 reverse transcriptase impact the susceptibility to the different nucleoside reverse transcriptase inhibitors in distinct ways.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2007;7(5):600-3.
2007: Els Keyaerts; Leen Vijgen; Christophe Pannecouque; Els J M Van Damme; Willy J Peumans; Herman Egberink; Jan Balzarini; Marc Van Ranst
Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.
Antiviral research 2007;75(3):179-87.
2007: Miguel Stevens; Jan Balzarini; Irene M Lagoja; Bernard Noppen; Katrien François; Arthur Van Aerschot; Piet Herdewijn; Erik De Clercq; Christophe Pannecouque
Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives.
Virology 2007;365(1):220-37.
2007: Takeshi Sakamoto; Matthew D Cullen; Tracy L Hartman; Karen M Watson; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems.
Journal of medicinal chemistry 2007;50(14):3314-21.
2007: Ravindra K Rawal; Raj Kamal Tripathi; Seturam B Katti; Christophe Pannecouque; Erik De Clercq
Synthesis and biological evaluation of 2,3-diaryl substituted-1,3-thiazolidin-4-ones as anti-HIV agents.
Medicinal chemistry (Shāriqah (United Arab Emirates)) 2007;3(4):355-63.
2007: Ravindra K Rawal; Renu Tripathi; Seturam B Katti; Christophe Pannecouque; Erik De Clercq
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents.
Bioorganic & medicinal chemistry 2007;15(9):3134-42.
2007: Lei Ji; Fen-Er Chen; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry 2007;50(8):1778-86.
2007: Maria Letizia Barreca; Angela Rao; Laura De Luca; Nunzio Iraci; Anna Maria Monforte; giovanni maga; Erik De Clercq; Christophe Pannecouque; Jan Balzarini; Alba Chimirri
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Bioorganic & medicinal chemistry letters 2007;17(7):1956-60.
2007: Miguel Stevens; Michela Pollicita; Christophe Pannecouque; Erik Verbeken; Oriana Tabarrini; Violetta Cecchetti; Stefano Aquaro; Carlo Federico Perno; Arnaldo Fravolini; Erik De Clercq; Dominique Schols; Jan Balzarini
Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives.
Antimicrobial agents and chemotherapy 2007;51(4):1407-13.
2007: Ravindra K Rawal; Renu Tripathi; Seturam B Katti; Christophe Pannecouque; Erik De Clercq
Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
Bioorganic & medicinal chemistry 2007;15(4):1725-31.
2007: Lei Ji; Fen-Er Chen; Bin Xie; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2007;42(2):198-204.
2007: Tokumi Maruyama; Yosuke Demizu; Shigetada Kozai; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Robert Snoecks; Graciela Andrei; Erik De Clercq
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1553-8.
2007: Adriana Garozzo; Christian C C Cutri; Christophe Pannecouque; Angelo Castro; Francesco Guerrera; Erik De Clercq
Isothiazole derivatives as antiviral agents.
Antiviral chemistry & chemotherapy 2007;18(5):277-83.
2007: Jingde Wu; Xinyong Liu; Xianchao Cheng; Yuan Cao; Defeng Wang; Zhong Li; Wenfang Xu; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs.
Molecules (Basel, Switzerland) 2007;12(8):2003-16.
2007: Najim A Al-Masoudi; Yaseen A Al-Soud; Erik De Clercq; Christophe Pannecouque
Nitroimidazoles Part 6. Synthesis, structure and in vitro anti-HIV activity of new 5-substituted piperazinyl-4-nitroimidazole derivatives.
Antiviral chemistry & chemotherapy 2007;18(4):191-200.
2007: Najim A Al-Masoudi; Yaseen A Al-Soud; Ibrahim A I Ali; Thilo Schuppler; Christophe Pannecouque; Erik De Clercq
New AZT analogues having 5'-alkylsulfonyl groups: synthesis and anti-HIV activity.
Nucleosides, nucleotides & nucleic acids 2007;26(3):223-30.
2006: Ren-Zhang Yan; Xin-Yong Liu; Wen-Fang Xu; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines.
Archives of pharmacal research 2006;29(11):957-62.
2006: Gina C Valks; Graeme McRobbie; Elizabeth A Lewis; Timothy J Hubin; Tina M Hunter; Peter J Sadler; Christophe Pannecouque; Erik De Clercq; Stephen J Archibald
Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.
Journal of medicinal chemistry 2006;49(21):6162-5.
2006: Pilar Canoa; María J González-Moa; Marta Teijeira; Carmen Terán; Eugenio Uriarte; Christophe Pannecouque; Erik De Clercq
Synthesis and anti-HIV activity of novel cyclopentenyl nucleoside analogues of 8-azapurine.
Chemical & pharmaceutical bulletin 2006;54(10):1418-20.
2006: Dirk Daelemans; Christophe Pannecouque
HIV-1 Rev function as target for antiretroviral drug development.
Current opinion in HIV and AIDS 2006;1(5):388-97.
2006: Lei Ji; Fen-Er Chen; Xiao-Qing Feng; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues.
Chemical & pharmaceutical bulletin 2006;54(9):1248-53.
2006: Bo-Liang Deng; Tracy L Hartman; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Mark Cushman
Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents.
Journal of medicinal chemistry 2006;49(17):5316-23.
2006: Karin Thevissen; Isabelle E J A François; Joris Winderickx; Christophe Pannecouque; Bruno P A Cammue
Ceramide involvement in apoptosis and apoptotic diseases.
Mini reviews in medicinal chemistry 2006;6(6):699-709.
2006: Najim A Al-Masoudi; Yaseen A Al-Soud; Aris Kalogerakis; Christophe Pannecouque; Erik De Clercq
Nitroimidazoles, part 2: Synthesis, antiviral and antitumor activity of new 4-nitroimidazoles.
Chemistry & biodiversity 2006;3(5):515-26.
2006: Miguel Stevens; Christophe Pannecouque; Erik De Clercq; Jan Balzarini
Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding.
Biochemical pharmacology 2006;71(8):1122-35.
2006: Bo-Liang Deng; Matthew D Cullen; Zhigang Zhou; Tracy L Hartman; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Phillip E Fanwick; Mark Cushman
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings.
Bioorganic & medicinal chemistry 2006;14(7):2366-74.
2006: Tokumi Maruyama; Shigetada Kozai; Yosuke Demizu; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Robert Snoecks; Graciela Andrei; Erik De Clercq
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.
Chemical & pharmaceutical bulletin 2006;54(3):325-33.
2006: Gerard Griffioen; Hein Duhamel; Nele Van Damme; Klaartje Pellens; Piotr Zabrocki; Christophe Pannecouque; Fred Van Leuven; Joris Winderickx; Stefaan Wera
A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential.
Biochimica et biophysica acta 2006;1762(3):312-8.
2005: Miguel Stevens; Jan Balzarini; Oriana Tabarrini; Graciela Andrei; Robert Snoeck; Violetta Cecchetti; Arnaldo Fravolini; Erik De Clercq; Christophe Pannecouque
Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation.
The Journal of antimicrobial chemotherapy 2005;56(5):847-55.
2005: Guang-Fu Sun; Yun-Yan Kuang; Fen-Er Chen; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues.
Archiv der Pharmazie 2005;338(10):457-61.
2005: Bo-Liang Deng; Tracy L Hartman; Robert W Buckheit; Christophe Pannecouque; Erik De Clercq; Phillip E Fanwick; Mark Cushman
Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2005;48(19):6140-55.
2005: Guang-Fu Sun; Xu-Xiang Chen; Fen-Er Chen; Yue-Ping Wang; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues.
Chemical & pharmaceutical bulletin 2005;53(8):886-92.
2005: Albert Nguyen Van Nhien; Cyrille Tomassi; Christophe Len; José Marco-Contelles; Jan Balzarini; Christophe Pannecouque; Erik De Clercq; Denis Postel
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
Journal of medicinal chemistry 2005;48(13):4276-84.
2005: Myriam Witvrouw; Valery Fikkert; Anke Hantson; Christophe Pannecouque; Barry R O'Keefe; James McMahon; Leonidas Stamatatos; Erik De Clercq; Anders Bolmstedt
Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.
Journal of virology 2005;79(12):7777-84.
2005: Maria Letizia Barreca; Angela Rao; Laura De Luca; Maria Zappalà; Anna Maria Monforte; giovanni maga; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; Alba Chimirri; Pietro Monforte
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
Journal of medicinal chemistry 2005;48(9):3433-7.
2005: Dirk Daelemans; Christophe Pannecouque; George Pavlakis; Oriana Tabarrini; Erik De Clercq
A novel and efficient approach to discriminate between pre- and post-transcription HIV inhibitors.
Molecular pharmacology 2005;67(5):1574-80.
2005: Tongfei Wu; Matheus Froeyen; Veerle Kempeneers; Christophe Pannecouque; Jing Wang; Roger Busson; Erik De Clercq; Piet Herdewijn
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents.
Journal of the American Chemical Society 2005;127(14):5056-65.
2005: Jan Balzarini; Miguel Stevens; Erik De Clercq; Dominique Schols; Christophe Pannecouque
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.
The Journal of antimicrobial chemotherapy 2005;55(2):135-8.
2005: Erik De Clercq; Graciela Andrei; Jan Balzarini; Pieter Leyssen; Lieve Naesens; Johan Neyts; Christophe Pannecouque; Robert Snoeck; Chunxiao Ying; Dana Hocková; Antonín Holý
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):331-41.
2005: Anke Hantson; Valery Fikkert; Barbara Van Remoortel; Christophe Pannecouque; Peter Cherepanov; Barry Matthews; George Holan; Erik De Clercq; Anne-Mieke Vandamme; zeger debyser; Myriam Witvrouw
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.
Antiviral chemistry & chemotherapy 2005;16(4):253-66.
2004: Yanping He; Fener Chen; Xiongjie Yu; Yueping Wang; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones.
Bioorganic chemistry 2004;32(6):536-48.
2004: Valery Fikkert; Anneleen Hombrouck; Barbara Van Remoortel; Marc De Maeyer; Christophe Pannecouque; Erik De Clercq; zeger debyser; Myriam Witvrouw
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.
AIDS (London, England) 2004;18(15):2019-28.
2004: Oriana Tabarrini; Miguel Stevens; Violetta Cecchetti; Stefano Sabatini; Micaela Dell'Uomo; Giuseppe Manfroni; Manlio Palumbo; Christophe Pannecouque; Erik De Clercq; Arnaldo Fravolini
Structure modifications of 6-aminoquinolones with potent anti-HIV activity.
Journal of medicinal chemistry 2004;47(22):5567-78.
2004: Jan Balzarini; Christophe Pannecouque; Lieve Naesens; Graciela Andrei; Robert Snoeck; Erik De Clercq; Dana Hocková; Antonín Holý
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1321-7.
2004: Myriam Witvrouw; Bénédicte Van Maele; Jo Vercammen; Anke Hantson; Yves Engelborghs; Erik De Clercq; Christophe Pannecouque; zeger debyser
Novel inhibitors of HIV-1 integration.
Current drug metabolism 2004;5(4):291-304.
2004: A Rao; Jan Balzarini; A Carbone; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
Antiviral research 2004;63(2):79-84.
2004: Christian C C Cutrì; Adriana Garozzo; Christophe Pannecouque; Angelo Castro; Francesco Guerrera; Erik De Clercq
Isothiazole derivatives as novel HIV replication inhibitors.
Antiviral chemistry & chemotherapy 2004;15(4):201-5.
2004: Yanping He; Fener Chen; Guangfu Sun; Yueping Wang; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.
Bioorganic & medicinal chemistry letters 2004;14(12):3173-6.
2004: Maximilian Silvestri; Muthukaman Nagarajan; Erik De Clercq; Christophe Pannecouque; Mark Cushman
Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2004;47(12):3149-62.
2004: Valérie Gagnard; Alain Leydet; Alain Morère; Jean-Louis Montero; Isabelle Lefèbvre; Gilles Gosselin; Christophe Pannecouque; Erick De Clercq
Synthesis and in vitro evaluation of S-acyl-3-thiopropyl prodrugs of Foscarnet.
Bioorganic & medicinal chemistry 2004;12(6):1393-402.
2004: Carole Anastasi; Olivier Hantz; Erik De Clercq; Christophe Pannecouque; Pascal Clayette; Nathalie Dereuddre-Bosquet; Dominique Dormont; Françoise Gondois-Rey; Ivan Hirsch; Jean-Louis Kraus
Potent nonclassical nucleoside antiviral drugs based on the N,N-diarylformamidine concept.
Journal of medicinal chemistry 2004;47(5):1183-92.
2004: Myriam Witvrouw; Christophe Pannecouque; William Switzer; Thomas M Folks; Erik De Clercq; Walid Heneine
Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis.
Antiviral therapy 2004;9(1):57-65.
2004: Tokumi Maruyama; Shigetada Kozai; Yosuke Demizu; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Robert Snoeck; Graciela Andrei; Erik De Clercq
Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1.
Nucleic acids symposium series (2004) 2004;(48):3-4.
2004: M Taourirte; L Ait Mohamed; A Rochdi; Jean-Jacques Vasseur; Susana Fernández; Miguel Ferrero; Vicente Gotor; Christophe Pannecouque; Erik De Clercq; Hassan Bihi Lazrek
Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity.
Nucleosides, nucleotides & nucleic acids 2004;23(4):701-14.
2004: Suzana Jaksa; Bogdan Kralj; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; Joze Kobe
How a modification (8-aza-3-deaza-2'-deoxyguanosine) influences the quadruplex structure of Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):77-88.
2004: Angela Rao; Jan Balzarini; Anna Carbone; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
Farmaco (Società chimica italiana : 1989) 2004;59(1):33-9.
2003: George Stamatiou; George B Foscolos; George Fytas; Antonios Kolocouris; Nicolas Kolocouris; Christophe Pannecouque; Myriam Witvrouw; Elizaveta Padalko; Johan Neyts; Erik De Clercq
Heterocyclic rimantadine analogues with antiviral activity.
Bioorganic & medicinal chemistry 2003;11(24):5485-92.
2003: Myriam Witvrouw; Christophe Pannecouque; Valery Fikkert; Anke Hantson; Barbara Van Remoortel; Marjan Hezareh; Erik De Clercq; Stephen J Brown
Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry.
Antiviral chemistry & chemotherapy 2003;14(6):321-8.
2003: Valery Fikkert; Bénédicte Van Maele; Jo Vercammen; Anke Hantson; Barbara Van Remoortel; Martine Michiels; Cristina Gurnari; Christophe Pannecouque; Marc De Maeyer; Yves Engelborghs; Erik De Clercq; zeger debyser; Myriam Witvrouw
Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Journal of virology 2003;77(21):11459-70.
2003: Miguel Stevens; Christophe Pannecouque; Erik De Clercq; Jan Balzarini
Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action.
Antimicrobial agents and chemotherapy 2003;47(10):3109-16.
2003: Tokumi Maruyama; Shigetada Kozai; Tetsuo Yamasaki; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Robert Snoeck; Graciela Andrei; Erik De Clercq
Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.
Antiviral chemistry & chemotherapy 2003;14(5):271-9.
2003: Miguel Stevens; Christophe Pannecouque; Erik De Clercq; Jan Balzarini
Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives.
Antimicrobial agents and chemotherapy 2003;47(9):2951-7.
2003: Carole Anastasi; Patrick Vlieghe; Olivier Hantz; Olivier Schorr; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq; Pascal Clayette; Nathalie Dereuddre-Bosquet; Dominique Dormont; Françoise Gondois-Rey; Ivan Hirsch; Jean-Louis Kraus
Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?
Bioorganic & medicinal chemistry letters 2003;13(15):2459-63.
2003: Christophe Galtier; Sylvie Mavel; Robert Snoeck; Graciela Andreï; Christophe Pannecouque; Myriam Witvrouw; Jan Balzarini; Erik De Clercq; Alain Gueiffier
Synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives.
Antiviral chemistry & chemotherapy 2003;14(4):177-82.
2003: Ge Meng; Fen-Er Chen; Erik De Clercq; Jan Balzarini; Christophe Pannecouque
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues.
Chemical & pharmaceutical bulletin 2003;51(7):779-89.
2003: Jan Balzarini; Christophe Pannecouque; Erik De Clercq; Andrey Y Pavlov; Svetlana S Printsevskaya; Olga V Miroshnikova; Marina I Reznikova; Maria N Preobrazhenskaya
Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics.
Journal of medicinal chemistry 2003;46(13):2755-64.
2003: L Ait Mohamed; M Taourirte; A Rochdi; Hassan Bihi Lazrek; Jean-Jacques Vasseur; Joachim W Engels; Christophe Pannecouque; Erik De Clercq
Synthesis of new homo and heterodimers of 2',3'-dideoxyinosine (ddI) using ester linkages.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):829-31.
2003: Irene M Lagoja; Christophe Pannecouque; Arthur Van Aerschot; Myriam Witvrouw; zeger debyser; Jan Balzarini; Piet Herdewijn; Erik De Clercq
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.
Journal of medicinal chemistry 2003;46(8):1546-53.
2003: Angela Rao; Anna Carbone; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.
Farmaco (Società chimica italiana : 1989) 2003;58(2):115-20.
2002: Valery Fikkert; Peter Cherepanov; Kristel Van Laethem; Anke Hantson; Barbara Van Remoortel; Christophe Pannecouque; Erik De Clercq; zeger debyser; Anne-Mieke Vandamme; Myriam Witvrouw
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.
Antimicrobial agents and chemotherapy 2002;46(12):3954-62.
2002: Maria Letizia Barreca; Jan Balzarini; Alba Chimirri; Erik De Clercq; Laura De Luca; Hans-Dieter Höltje; Monika Höltje; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Angela Rao; Maria Zappalà
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Journal of medicinal chemistry 2002;45(24):5410-3.
2002: Angela Rao; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles.
Farmaco (Società chimica italiana : 1989) 2002;57(10):819-23.
2002: Wim Pluymers; Godwin C G Pais; Bénédicte Van Maele; Christophe Pannecouque; Valery Fikkert; Terrence R Burke; Erik De Clercq; Myriam Witvrouw; Nouri Neamati; zeger debyser
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives.
Antimicrobial agents and chemotherapy 2002;46(10):3292-7.
2002: Angela Rao; Anna Carbone; Alba Chimirri; Erik De Clercq; Anna Maria Monforte; Pietro Monforte; Christophe Pannecouque; Maria Zappalà
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.
Farmaco (Società chimica italiana : 1989) 2002;57(9):747-51.
2002: Christophe Pannecouque; Wim Pluymers; Bénédicte Van Maele; Victor Tetz; Peter Cherepanov; Erik De Clercq; Myriam Witvrouw; zeger debyser
New class of HIV integrase inhibitors that block viral replication in cell culture.
Current biology : CB 2002;12(14):1169-77.
2002: Jan Balzarini; Christophe Pannecouque; Erik De Clercq; Stefano Aquaro; Carlo Federico Perno; Herman Egberink; Antonín Holý
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.
Antimicrobial agents and chemotherapy 2002;46(7):2185-93.
2002: Sofía Salido; Joaquín Altarejos; Manuel Nogueras; Adolfo Sánchez; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Chemical studies of essential oils of Juniperus oxycedrus ssp. badia.
Journal of ethnopharmacology 2002;81(1):129-34.
2002: Vibha Mishra; Surendra N Pandeya; Christophe Pannecouque; Myriam Witvrouw; E de Clercq
Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone.
Archiv der Pharmazie 2002;335(5):183-6.
2002: Patrick Vlieghe; Thierry Clerc; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq; Jean-Pierre Salles; Jean-Louis Kraus
Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities.
Journal of medicinal chemistry 2002;45(6):1275-83.
2002: Antonios Kolocouris; Kostas Dimas; Christophe Pannecouque; Myriam Witvrouw; George B Foscolos; George Stamatiou; George Fytas; Grigoris Zoidis; Nicolas Kolocouris; Graciela Andrei; Robert Snoeck; Erik De Clercq
New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
Bioorganic & medicinal chemistry letters 2002;12(5):723-7.
2002: Marina Kritsanida; Anastasia Mouroutsou; Panagiotis Marakos; Nicole Pouli; Spyroula Papakonstantinou-Garoufalias; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
Farmaco (Società chimica italiana : 1989) 2002;57(3):253-7.
2002: Omar Moukha-chafiq; Mohamed Labd Taha; Hassan Bihi Lazrek; Jean-Jacques Vasseur; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines.
Farmaco (Società chimica italiana : 1989) 2002;57(1):27-32.
2001: Hassan Bihi Lazrek; M Taourirte; T Oulih; Jean Louis Barascut; Jean-Louis Imbach; Christophe Pannecouque; M Witrouw; Erik De Clercq
Synthesis and anti-HIV activity of new modified 1,2,3-triazole acyclonucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(12):1949-60.
2001: A Chaouni-Enabdallah; Christophe Galtier; Hassan Allouchi; A Kherbeche; Olivier Chavignon; Jean-Claude Teulade; Myriam Witvrouw; Christophe Pannecouque; Robert Snoeck; Graciela Andrei; Jan Balzarini; Erik De Clercq; Florence Fauvelle; Cécile Enguehard; Alain Gueiffier
3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents.
Chemical & pharmaceutical bulletin 2001;49(12):1631-5.
2001: A Casimiro-Garcia; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Loftus; Jim A Turpin; Robert W Buckheit; Phillip E Fanwick; Mark Cushman
Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments.
Bioorganic & medicinal chemistry 2001;9(11):2827-41.
2001: O Moukha-Hafiq; Mohamed Labd Taha; Hassan Bihi Lazrek; Jean-Jacques Vasseur; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis and biological evaluation of some 4-substituted 1-[1-(4-hydroxybutyl)-1,2,3-triazol-(4 &5)-ylmethyl]-1H-pyrazolo- 13,4-dipyrimidines.
Nucleosides, nucleotides & nucleic acids 2001;20(10-11):1811-21.
2001: Omar Moukha-chafiq; Mohamed Labd Taha; Hassan Bihi Lazrek; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq; Jean Louis Barascut; Jean-Louis Imbach
Synthesis and biological activity of 4-substituted 1-[1-(2-hydroxyethoxy)-methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines.
Nucleosides, nucleotides & nucleic acids 2001;20(10-11):1797-810.
2001: Patrick Vlieghe; Thierry Clerc; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq; Jean-Pierre Salles; Jean-Louis Kraus
New 3'-azido-3'-deoxythymidin-5'-yl O-(4-hydroxyalkyl or -alkenyl or -alkylepoxide) carbonate prodrugs: synthesis and anti-HIV evaluation.
Journal of medicinal chemistry 2001;44(18):3014-21.
2001: Maria Letizia Barreca; Alba Chimirri; Laura De Luca; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; Jan Balzarini; Erik De Clercq; Christophe Pannecouque; Myriam Witvrouw
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.
Bioorganic & medicinal chemistry letters 2001;11(13):1793-6.
2001: A Chaouni-Benabdallah; Christophe Galtier; Hassan Allouchi; A Kherbeche; Jean-Claude Debouzy; Jean-Claude Teulade; Olivier Chavignon; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; Cécile Enguehard; Alain Gueiffier
Synthesis of 3-nitrosoimidazo[1,2-a]pyridine derivatives as potential antiretroviral agents.
Archiv der Pharmazie 2001;334(7):224-8.
2001: Alba Chimirri; Pietro Monforte; Angela Rao; Maria Zappalà; Anna Maria Monforte; G De Sarro; Christophe Pannecouque; Myriam Witvrouw; Jan Balzarini; Erik De Clercq
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 2001;12(3):169-74.
2001: Kristel Van Laethem; Myriam Witvrouw; Christophe Pannecouque; Barbara Van Remoortel; Jean-Claude Schmit; Robert M Esnouf; JP Kleim; Jan Balzarini; Jan Desmyter; Erik De Clercq; Anne-Mieke Vandamme
Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype.
AIDS (London, England) 2001;15(5):553-61.
2001: Patrick Vlieghe; Frederic Bihel; Thierry Clerc; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq; Jean-Pierre Salles; Jean-Claude Chermann; Jean-Louis Kraus
New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.
Journal of medicinal chemistry 2001;44(5):777-86.
2001: K C Santhosh; G C Paul; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Loftus; Jim A Turpin; Robert W Buckheit; Mark Cushman
Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.
Journal of medicinal chemistry 2001;44(5):703-14.
2001: Athanasia Varvaresou; Kritonas Iakovou; EC Filippatos; C Souli; Theodora Calogeropoulou; I Ioannidou; Angeliki P Kourounakis; Christophe Pannecouque; Myriam Witvrouw; Elizaveta Padalko; Johan Neyts; Erik De Clercq; Andrew Tsotinis
Synthesis, antiretroviral and antioxidant evaluation of a series of new benzo[b]furan derivatives.
Arzneimittel-Forschung 2001;51(2):156-62.
2000: K C Santhosh; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Loftus; Jim A Turpin; Robert W Buckheit; Mark Cushman
Anti-HIV activity of a series of cosalane amino acid conjugates.
Bioorganic & medicinal chemistry letters 2000;10(22):2505-8.
2000: Myriam Witvrouw; Valery Fikkert; Wim Pluymers; Barry Matthews; K Mardel; Dominique Schols; J Raff; zeger debyser; Erik De Clercq; George Holan; Christophe Pannecouque
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.
Molecular pharmacology 2000;58(5):1100-8.
2000: G C Paul; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Loftus; Jim A Turpin; Robert W Buckheit; Mark Cushman
Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates.
Bioorganic & medicinal chemistry letters 2000;10(18):2149-52.
2000: Wim Pluymers; Nouri Neamati; Christophe Pannecouque; Valery Fikkert; C Marchand; Terrence R Burke; Y Pommier; Dominique Schols; Erik De Clercq; zeger debyser; Myriam Witvrouw
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.
Molecular pharmacology 2000;58(3):641-8.
2000: Kristien Van Vaerenbergh; Kristel Van Laethem; J Albert; C A Boucher; Bonaventura Clotet; Marco Floridia; J Gerstoft; B Hejdeman; C Nielsen; Christophe Pannecouque; L Perrin; Maria F Pirillo; Lidia Ruiz; Jean-Claude Schmit; F Schneider; A Schoolmeester; R Schuurman; Hans-Jürgen Stellbrink; Lieven Stuyver; Jan van Lunzen; Barbara Van Remoortel; Eric Van Wijngaerden; STEFANO VELLA; Myriam Witvrouw; S Yerly; Erik De Clercq; J Destmyer; Anne-Mieke Vandamme
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues.
Antimicrobial agents and chemotherapy 2000;44(8):2109-17.
2000: Myriam Witvrouw; Christophe Pannecouque; Jan Desmyter; Erik De Clercq; Koen Andries
In vitro evaluation of the effect of temporary removal of HIV drug pressure.
Antiviral research 2000;46(3):215-21.
2000: Myriam Witvrouw; H Weigold; Christophe Pannecouque; Dominique Schols; Erik De Clercq; George Holan
Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.
Journal of medicinal chemistry 2000;43(5):778-83.
2000: A Casimiro-Garcia; Erik De Clercq; Christophe Pannecouque; M Witvrouw; TL Stup; Jim A Turpin; Robert W Buckheit; Mark Cushman
Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain.
Bioorganic & medicinal chemistry 2000;8(1):191-200.
2000: Dirk Daelemans; Dominique Schols; Myriam Witvrouw; Christophe Pannecouque; Sigrid Hatse; Sonia Van Dooren; François Hamy; Thomas Klimkait; Erik De Clercq; Anne-Mieke Vandamme
A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.
Molecular pharmacology 2000;57(1):116-24.
1999: M E Arranz; JA Díaz; ST Ingate; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; S Vega
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 1999;7(12):2811-22.
1999: Jan Van Gelder; Myriam Witvrouw; Christophe Pannecouque; Geoffrey Henson; Gary J Bridger; Lieve Naesens; Erik De Clercq; Pieter Annaert; Manijeh Shafiee; Guy Van den Mooter; Renaat Kinget; Patrick Augustijns
Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.
International journal of pharmaceutics 1999;186(2):127-36.
1999: Alba Chimirri; Silvana Grasso; Pietro Monforte; Angela Rao; Maria Zappalà; Anna Maria Monforte; Christophe Pannecouque; Myriam Witvrouw; Jan Balzarini; Erik De Clercq
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 1999;10(4):211-7.
1999: Myriam Witvrouw; Christophe Pannecouque; Erik De Clercq; E Fernández-Alvarez; JL Marco
Inhibition of human immunodeficiency virus type (HIV-1) replication by some diversely functionalized spirocyclopropyl derivatives.
Archiv der Pharmazie 1999;332(5):163-6.
1999: Surendra N Pandeya; Perumal Yogeeswari; Dharmarajan Sriram; E de Clercq; Christophe Pannecouque; Myriam Witvrouw
Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives.
Chemotherapy 1999;45(3):192-6.
1998: Alain Leydet; C Moullet; JP Roque; M Witvrouw; Christophe Pannecouque; G Andrei; R Snoeck; J Neyts; D Schols; Erick De Clercq
Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.
Journal of medicinal chemistry 1998;41(25):4927-32.
1998: Vibha Mishra; Surendra N Pandeya; E DeClercq; Christophe Pannecouque; Myriam Witvrouw
Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.
Pharmaceutica acta Helvetiae 1998;73(4):215-8.
1998: E Arranz; JA Díaz; ST Ingate; Myriam Witvrouw; Christophe Pannecouque; Jan Balzarini; Erik De Clercq; S Vega
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.
Journal of medicinal chemistry 1998;41(21):4109-17.
1998: Alba Chimirri; Silvana Grasso; Anna Maria Monforte; Pietro Monforte; Angela Rao; Maria Zappalà; G Bruno; F Nicolò; Christophe Pannecouque; Myriam Witvrouw; Erik De Clercq
Synthesis, structure and in vitro anti-human immunodeficiency virus activity of novel 3-methyl-1H,3H-thiazolo[3,4-a]benzimidazoles.
Antiviral chemistry & chemotherapy 1998;9(5):431-8.
1998: Myriam Witvrouw; Dirk Daelemans; Christophe Pannecouque; Johan Neyts; Graciela Andrei; Robert Snoeck; Anne-Mieke Vandamme; Jan Balzarini; Jan Desmyter; M Baba; Erik De Clercq
Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.
Antiviral chemistry & chemotherapy 1998;9(5):403-11.
1998: Myriam Witvrouw; M E Arranz; Christophe Pannecouque; Ruben Declercq; H Jonckheere; Jean-Claude Schmit; Anne-Mieke Vandamme; J A Diaz; ST Ingate; Jan Desmyter; Robert M Esnouf; Luc Van Meervelt; S Vega; Jan Balzarini; Erik De Clercq
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.
Antimicrobial agents and chemotherapy 1998;42(3):618-23.
1998: José A Esté; C Cabrera; Dominique Schols; Peter Cherepanov; A Gutierrez; Myriam Witvrouw; Christophe Pannecouque; zeger debyser; RF Rando; B Clotet; Jan Desmyter; E De Clercq
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
Molecular pharmacology 1998;53(2):340-5.
1997: Dirk Daelemans; José A Esté; Myriam Witvrouw; Christophe Pannecouque; H Jonckheere; Stefano Aquaro; Carlo Federico Perno; Erik De Clercq; Anne-Mieke Vandamme
S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation.
Molecular pharmacology 1997;52(6):1157-63.
1997: Jan Balzarini; J Kruining; O Wedgwood; Christophe Pannecouque; Stefano Aquaro; Carlo Federico Perno; Lieve Naesens; Myriam Witvrouw; Rudolf Heijtink; Erik De Clercq; Christopher McGuigan
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
FEBS letters 1997;410(2-3):324-8.
1997: Jan Balzarini; T Vahlenkamp; Herman Egberink; K Hartmann; Myriam Witvrouw; Christophe Pannecouque; P Casara; J F Navé; Erik De Clercq
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice.
Antimicrobial agents and chemotherapy 1997;41(3):611-6.
1997: Myriam Witvrouw; Jan Balzarini; Christophe Pannecouque; S Jhaumeer-Laulloo; José A Esté; Dominique Schols; Peter Cherepanov; Jean-Claude Schmit; zeger debyser; Anne-Mieke Vandamme; Jan Desmyter; S R Ramadas; Erik De Clercq
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.
Antimicrobial agents and chemotherapy 1997;41(2):262-8.
1991: piet wigerinck; Christophe Pannecouque; Robert Snoeck; P Claes; E De Clercq; Piet Herdewijn
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
Journal of medicinal chemistry 1991;34(8):2383-9.