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Christophe Pannecouque

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Publications

TOP 3
Yu Mingyan; Liu Xinyong; Li Zhenyu; Liu Shuai; Pannecouque Christophe; Clercq Erik De
Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.
François Katrien O; Pannecouque Christophe; Auwerx Joeri; Lozano Virginia; Pérez-Pérez Maria-Jésus; Schols Dominique; Balzarini Jan
The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential.
Zhan Peng; Liu Xinyong; Fang Zengjun; Li Zhenyu; Pannecouque Christophe; De Clercq Erik
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.

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All Publications

2009: Yu Mingyan; Liu Xinyong; Li Zhenyu; Liu Shuai; Pannecouque Christophe; Clercq Erik De
Synthesis and biological evaluation of novel 2-(substituted phenylaminocarbonylmethylthio)-6-(2,6-dichlorobenzyl)-pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs.
Bioorganic & medicinal chemistry 2009;17(22):7749-54.
2009: François Katrien O; Pannecouque Christophe; Auwerx Joeri; Lozano Virginia; Pérez-Pérez Maria-Jésus; Schols Dominique; Balzarini Jan
The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential.
Antimicrobial agents and chemotherapy 2009;53(11):4852-9.
2009: Zhan Peng; Liu Xinyong; Fang Zengjun; Li Zhenyu; Pannecouque Christophe; De Clercq Erik
Synthesis and anti-HIV activity evaluation of 2-(4-(naphthalen-2-yl)-1,2,3-thiadiazol-5-ylthio)-N-acetamides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2009;44(11):4648-53.
2009: Cullen Matthew D; Ho William C; Bauman Joseph D; Das Kalyan; Arnold Eddy; Hartman Tracy L; Watson Karen M; Buckheit Robert W; Pannecouque Christophe; De Clercq Erik; Cushman Mark
Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase.
Journal of medicinal chemistry 2009;52(20):6467-73.
2009: Darque Albert; Dumètre Aurélien; Hutter Sébastien; Casano Gilles; Robin Maxime; Pannecouque Christophe; Azas Nadine
Synthesis and biological evaluation of new heterocyclic quinolinones as anti-parasite and anti-HIV drug candidates.
Bioorganic & medicinal chemistry letters 2009;19(20):5962-4.
2009: Zhan Peng; Liu Xinyong; Fang Zengjun; Pannecouque Christophe; De Clercq Erik
1,2,3-Selenadiazole thioacetanilides: synthesis and anti-HIV activity evaluation.
Bioorganic & medicinal chemistry 2009;17(17):6374-9.
2009: Liang Yong-Hong; Feng Xiao-Qing; Zeng Zhao-Sen; Chen Fen-Er; Balzarini Jan; Pannecouque Christophe; De Clercq Erik
Design, synthesis, and SAR of naphthyl-substituted Diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
ChemMedChem 2009;4(9):1537-45.
2009: el-Sabbagh Osama I; Baraka Mohamed M; Ibrahim Samy M; Pannecouque Christophe; Andrei Graciela; Snoeck Robert; Balzarini Jan; Rashad Adel A
Synthesis and antiviral activity of new pyrazole and thiazole derivatives.
European journal of medicinal chemistry 2009;44(9):3746-53.
2009: Karakus Sevgi; Güniz Küçükgüzel S; Küçükgüzel Ilkay; De Clercq Erik; Pannecouque Christophe; Andrei Graciela; Snoeck Robert; Sahin Fikrettin; Bayrak Omer Faruk
Synthesis, antiviral and anticancer activity of some novel thioureas derived from N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide.
European journal of medicinal chemistry 2009;44(9):3591-5.
2009: Zhan Peng; Liu Xinyong; Zhu Junjie; Fang Zengjun; Li Zhenyu; Pannecouque Christophe; Clercq Erik De
Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2009;17(16):5775-81.
2009: Zhan Peng; Liu Xinyong; Li Zhenyu; Fang Zengjun; Li Zhong; Wang Defeng; Pannecouque Christophe; Clercq Erik De
Novel 1,2,3-thiadiazole derivatives as HIV-1 NNRTIs with improved potency: Synthesis and preliminary SAR studies.
Bioorganic & medicinal chemistry 2009;17(16):5920-7.
2009: Monforte Anna-Maria; Logoteta Patrizia; Ferro Stefania; Luca Laura De; Iraci Nunzio; Maga Giovanni; Clercq Erik De; Pannecouque Christophe; Chimirri Alba
Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.
Bioorganic & medicinal chemistry 2009;17(16):5962-7.
2009: Santos Cledir R; Capela Rita; Pereira Cláudia S G P; Valente Emília; Gouveia Luís; Pannecouque Christophe; De Clercq Erik; Moreira Rui; Gomes Paula
Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design.
European journal of medicinal chemistry 2009;44(6):2339-46.
2009: Mahajan Dharmesh H; Pannecouque Christophe; De Clercq Erik; Chikhalia Kishor H
Synthesis and studies of new 2-(coumarin-4-yloxy)-4,6-(substituted)-S-triazine derivatives as potential anti-HIV agents.
Archiv der Pharmazie 2009;342(5):281-90.
2009: Xiong Yuan-Zhen; Chen Fen-Er; Balzarini Jan; De Clercq Erik; Pannecouque Christophe
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 13: synthesis of fluorine-containing diaryltriazine derivatives for in vitro anti-HIV evaluation against wild-type strain.
Chemistry & biodiversity 2009;6(4):561-8.
2009: Naesens Lieve; Vanderlinden Evelien; Roth Erzsébet; Jeko József; Andrei Graciela; Snoeck Robert; Pannecouque Christophe; Illyés Eszter; Batta Gyula; Herczegh Pál; Sztaricskai Ferenc
Anti-influenza virus activity and structure-activity relationship of aglycoristocetin derivatives with cyclobutenedione carrying hydrophobic chains.
Antiviral research 2009;82(1):89-94.
2009: Khan Abid; Nicholson Gary; Greenman John; Madden Leigh; McRobbie Graeme; Pannecouque Christophe; De Clercq Erik; Ullom Robert; Maples Danny L; Maples Randall D; Silversides Jon D; Hubin Timothy J; Archibald Stephen J
Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultrarigid metal complexes.
Journal of the American Chemical Society 2009;131(10):3416-7.
2009: Deng Bo-Liang; Zhao Yujie; Hartman Tracy L; Watson Karen; Buckheit Robert W; Pannecouque Christophe; De Clercq Erik; Cushman Mark
Synthesis of alkenyldiarylmethanes (ADAMs) containing benzo[d]isoxazole and oxazolidin-2-one rings, a new series of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2009;44(3):1210-4.
2009: Wang Yue-Ping; Chen Fen-Er; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2009;44(3):1016-23.
2009: Xiong Yuan-Zhen; Hu Hai-Rong; Chen Fen-Er; Balzarini Jan; Pannecouque Christophe; de Clercq Erik
Non-nucleoside reverse transcriptase inhibitors (Part 18): synthesis and anti-HIV activity of 4-allylamino or 4-azido substituted diaryltriazines.
Yao xue xue bao = Acta pharmaceutica Sinica 2009;44(2):145-9.
2009: Feng Xiao-Qing; Liang Yong-Hong; Zeng Zhao-Sen; Chen Fen-Er; Balzarini Jan; Pannecouque Christophe; De Clercq Erik
Structural modifications of DAPY analogues with potent anti-HIV-1 activity.
ChemMedChem 2009;4(2):219-24.
2009: Bannwarth Ludovic; Rose Thierry; Dufau Laure; Vanderesse Régis; Dumond Julien; Jamart-Grégoire Brigitte; Pannecouque Christophe; De Clercq Erik; Reboud-Ravaux Michèle
Dimer disruption and monomer sequestration by alkyl tripeptides are successful strategies for inhibiting wild-type and multidrug-resistant mutated HIV-1 proteases.
Biochemistry 2009;48(2):379-87.
2009: Massari Serena; Daelemans Dirk; Manfroni Giuseppe; Sabatini Stefano; Tabarrini Oriana; Pannecouque Christophe; Cecchetti Violetta
Studies on anti-HIV quinolones: new insights on the C-6 position.
Bioorganic & medicinal chemistry 2009;17(2):667-74.
2009: Zhan Peng; Liu Xinyong; Li Zhenyu; Pannecouque Christophe; De Clercq Erik
Design strategies of novel NNRTIs to overcome drug resistance.
Current medicinal chemistry 2009;16(29):3903-17.
2008: Rawal Ravindra K; Tripathi Rajkamal; Katti S B; Pannecouque Christophe; De Clercq Erik
Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
European journal of medicinal chemistry 2008;43(12):2800-6.
2008: Van Neck Tine; Pannecouque Christophe; Vanstreels Els; Stevens Miguel; Dehaen Wim; Daelemans Dirk
Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
Bioorganic & medicinal chemistry 2008;16(21):9487-97.
2008: Zhan Peng; Liu Xinyong; Cao Yuan; Wang Yan; Pannecouque Christophe; De Clercq Erik
1,2,3-Thiadiazole thioacetanilides as a novel class of potent HIV-1 non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(20):5368-71.
2008: Tabarrini Oriana; Massari Serena; Daelemans Dirk; Stevens Miguel; Manfroni Giuseppe; Sabatini Stefano; Balzarini Jan; Cecchetti Violetta; Pannecouque Christophe; Fravolini Arnaldo
Structure-activity relationship study on anti-HIV 6-desfluoroquinolones.
Journal of medicinal chemistry 2008;51(17):5454-8.
2008: Rawal Ravindra K; Tripathi Rajkamal; Kulkarni Smitha; Paranjape R; Katti S B; Pannecouque Christophe; De Clercq Erik
2-(2,6-Dihalo-phenyl)-3-heteroaryl-2-ylmethyl-1, 3-thiazolidin-4-ones: anti-HIV agents.
Chemical biology & drug design 2008;72(2):147-54.
2008: Monforte Anna-Maria; Rao Angela; Logoteta Patrizia; Ferro Stefania; De Luca Laura; Barreca Maria Letizia; Iraci Nunzio; Maga Giovanni; De Clercq Erik; Pannecouque Christophe; Chimirri Alba
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2008;16(15):7429-35.
2008: Santos Cledir; Morais José; Gouveia Luís; de Clercq Erik; Pannecouque Christophe; Nielsen Carsten Uhd; Steffansen Bente; Moreira Rui; Gomes Paula
Dipeptide derivatives of AZT: synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity.
ChemMedChem 2008;3(6):970-8.
2008: Xiong Yuan-Zhen; Chen Fen-Er; Balzarini Jan; De Clercq Erik; Pannecouque Christophe
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.
European journal of medicinal chemistry 2008;43(6):1230-6.
2008: Al-Soud Yaseen A; Al-Masoudi Najim A; Schuppler Thilo; De Clercq Erik; Pannecouque Christophe
Microwave-assisted synthesis and anti-HIV activity of new acyclic C-nucleosides of 3-(D-ribo-tetritol-1-yl)-5-mercapto-1,2,4-triazoles. Part 1.
Nucleosides, nucleotides & nucleic acids 2008;27(5):469-83.
2008: Tomassi Cyrille; Nguyen Van Nhien Albert; Marco-Contelles José; Balzarini Jan; Pannecouque Christophe; De Clercq Erik; Soriano Elena; Postel Denis
Synthesis, anti-HIV-1 activity, and modeling studies of N-3 Boc TSAO compound.
Bioorganic & medicinal chemistry letters 2008;18(7):2277-81.
2008: Tomassi Cyrille; Nguyen Van Nhien Albert; Marco-Contelles José; Balzarini Jan; Pannecouque Christophe; De Clercq Erik; Postel Denis
Synthesis and anti-HIV1 biological activity of novel 5''-ATSAO compounds.
Bioorganic & medicinal chemistry 2008;16(8):4733-41.
2008: Wang Yue-Ping; Chen Fen-Er; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Synthesis and biological evaluation of novel 6-substituted 5-alkyl-2-(arylcarbonylmethylthio)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 2008;16(7):3887-94.
2008: Liu Xin-yong; Yan Ren-zhang; Wang Yan; Zhan Peng; De Clercq Erik; Pannecouque Christophe; Witvrouw Myriam; Molina Maria Teresa; Vega Salvador
Synthesis and anti-HIV activity evaluation of novel 2,4-disubstituted 7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo-[4,5-e][1,2]thiadiazines.
Archiv der Pharmazie 2008;341(4):216-22.
2008: Cullen Matthew D; Cheung York-Fong; Houslay Miles D; Hartman Tracy L; Watson Karen M; Buckheit Robert W; Pannecouque Christophe; De Clercq Erik; Cushman Mark
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors.
Bioorganic & medicinal chemistry letters 2008;18(4):1530-3.
2008: Wang Yueping; Chen Fen-Er; Balzarini Jan; De Clercq Erik; Pannecouque Christophe
Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10. Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues.
Chemistry & biodiversity 2008;5(1):168-76.
2008: Cullen Matthew D; Sarkar Taradas; Hamel Ernest; Hartman Tracy L; Watson Karen M; Buckheit Robert W; Pannecouque Christophe; De Clercq Erik; Cushman Mark
Inhibition of tubulin polymerization by select alkenyldiarylmethanes.
Bioorganic & medicinal chemistry letters 2008;18(2):469-73.
2008: Lin Yongqiang; Liu Xinyong; Yan Renzhang; Li Jin; Pannecouque Christophe; Witvrouw Myriam; De Clercq Erik
Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs).
Bioorganic & medicinal chemistry 2008;16(1):157-63.
2008: Pannecouque Christophe; Daelemans Dirk; De Clercq Erik
Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later.
Nature protocols 2008;3(3):427-34.
2007: Al-Soud Yaseen A; Al-Masoudi Najim A; Hassan Hamed Gh; De Clercq Erik; Pannecouque Christophe
Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives.
Acta pharmaceutica (Zagreb, Croatia) 2007;57(4):379-93.
2007: McRobbie Graeme; Valks Gina C; Empson Christopher J; Khan Abid; Silversides Jon D; Pannecouque Christophe; De Clercq Erik; Fiddy Steven G; Bridgeman Adam J; Young Nigel A; Archibald Stephen J
Probing key coordination interactions: configurationally restricted metal activated CXCR4 antagonists.
Dalton transactions (Cambridge, England : 2003) 2007;(43):5008-18.
2007: Cullen Matthew D; Deng Bo-Liang; Hartman Tracy L; Watson Karen M; Buckheit Robert W; Pannecouque Christophe; Clercq Erik De; Cushman Mark
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability.
Journal of medicinal chemistry 2007;50(20):4854-67.
2007: Van Laethem Kristel; Pannecouque Christophe; Vandamme Anne-Mieke
Mutations at 65 and 70 within the context of a Q151M cluster in human immunodeficiency virus type 1 reverse transcriptase impact the susceptibility to the different nucleoside reverse transcriptase inhibitors in distinct ways.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2007;7(5):600-3.
2007: Keyaerts Els; Vijgen Leen; Pannecouque Christophe; Van Damme Els; Peumans Willy; Egberink Herman; Balzarini Jan; Van Ranst Marc
Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle.
Antiviral research 2007;75(3):179-87.
2007: Stevens Miguel; Balzarini Jan; Lagoja Irene M; Noppen Bernard; François Katrien; Van Aerschot Arthur; Herdewijn Piet; De Clercq Erik; Pannecouque Christophe
Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives.
Virology 2007;365(1):220-37.
2007: Rawal Ravindra K; Tripathi Raj Kamal; Katti S B; Pannecouque Christophe; De Clercq Erik
Synthesis and biological evaluation of 2,3-diaryl substituted-1,3-thiazolidin-4-ones as anti-HIV agents.
Medicinal chemistry (Shariqah (United Arab Emirates)) 2007;3(4):355-63.
2007: Sakamoto Takeshi; Cullen Matthew D; Hartman Tracy L; Watson Karen M; Buckheit Robert W; Pannecouque Christophe; De Clercq Erik; Cushman Mark
Synthesis and anti-HIV activity of new metabolically stable alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors incorporating N-methoxy imidoyl halide and 1,2,4-oxadiazole systems.
Journal of medicinal chemistry 2007;50(14):3314-21.
2007: Rawal Ravindra K; Tripathi Rajkamal; Katti S B; Pannecouque Christophe; De Clercq Erik
Synthesis and evaluation of 2-(2,6-dihalophenyl)-3-pyrimidinyl-1,3-thiazolidin-4-one analogues as anti-HIV-1 agents.
Bioorganic & medicinal chemistry 2007;15(9):3134-42.
2007: Ji Lei; Chen Fen-Er; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Synthesis and anti-HIV-1 activity evaluation of 5-alkyl-2-alkylthio-6-(arylcarbonyl or alpha-cyanoarylmethyl)-3,4-dihydropyrimidin-4(3H)-ones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
Journal of medicinal chemistry 2007;50(8):1778-86.
2007: Barreca Maria Letizia; Rao Angela; De Luca Laura; Iraci Nunzio; Monforte Anna-Maria; Maga Giovanni; De Clercq Erik; Pannecouque Christophe; Balzarini Jan; Chimirri Alba
Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains.
Bioorganic & medicinal chemistry letters 2007;17(7):1956-60.
2007: Stevens Miguel; Pollicita Michela; Pannecouque Christophe; Verbeken Erik; Tabarrini Oriana; Cecchetti Violetta; Aquaro Stefano; Perno Carlo Federico; Fravolini Arnaldo; De Clercq Erik; Schols Dominique; Balzarini Jan
Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives.
Antimicrobial agents and chemotherapy 2007;51(4):1407-13.
2007: Rawal Ravindra K; Tripathi Rajkamal; Katti S B; Pannecouque Christophe; De Clercq Erik
Design, synthesis, and evaluation of 2-aryl-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
Bioorganic & medicinal chemistry 2007;15(4):1725-31.
2007: Ji Lei; Chen Fen-Er; Xie Bin; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Synthesis and anti-HIV activity evaluation of 1-[(alkenyl or alkynyl or alkyloxy)methyl]-5-alkyl-6-(1-naphthoyl)-2,4-pyrimidinediones as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
European journal of medicinal chemistry 2007;42(2):198-204.
2007: Maruyama Tokumi; Demizu Yosuke; Kozai Shigetada; Witvrouw Myriam; Pannecouque Christophe; Balzarini Jan; Snoecks Robert; Andrei Graciella; De Clercq Erik
Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV.
Nucleosides, nucleotides & nucleic acids 2007;26(10-12):1553-8.
2007: Garozzo Adriana; Cutri Christian C C; Pannecouque Christophe; Castro Angelo; Guerrera Francesco; De Clercq Erik
Isothiazole derivatives as antiviral agents.
Antiviral chemistry & chemotherapy 2007;18(5):277-83.
2007: Wu Jingde; Liu Xinyong; Cheng Xianchao; Cao Yuan; Wang Defeng; Li Zhong; Xu Wenfang; Pannecouque Christophe; Witvrouw Myriam; De Clercq Erik
Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs.
Molecules (Basel, Switzerland) 2007;12(8):2003-16.
2007: Al-Masoudi Najim A; Al-Soud Yaseen A; De Clercq Erik; Pannecouque Christophe
Nitroimidazoles Part 6. Synthesis, structure and in vitro anti-HIV activity of new 5-substituted piperazinyl-4-nitroimidazole derivatives.
Antiviral chemistry & chemotherapy 2007;18(4):191-200.
2007: Al-Masoudi Najim A; Al-Soud Yaseen A; Ali Ibrahim A I; Schuppler Thilo; Pannecouque Christoph; De Clercq Erik
New AZT analogues having 5'-alkylsulfonyl groups: synthesis and anti-HIV activity.
Nucleosides, nucleotides & nucleic acids 2007;26(3):223-30.
2006: Yan Ren-Zhang; Liu Xin-Yong; Xu Wen-Fang; Pannecouque Christophe; Witvrouw Myriam; De Clercq Erik
Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines.
Archives of pharmacal research 2006;29(11):957-62.
2006: Valks Gina C; McRobbie Graeme; Lewis Elizabeth A; Hubin Timothy J; Hunter Tina M; Sadler Peter J; Pannecouque Christophe; De Clercq Erik; Archibald Stephen J
Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.
Journal of medicinal chemistry 2006;49(21):6162-5.
2006: Canoa Pilar; González-Moa María J; Teijeira Marta; Terán Carmen; Uriarte Eugenio; Pannecouque Christophe; De Clercq Erik
Synthesis and anti-HIV activity of novel cyclopentenyl nucleoside analogues of 8-azapurine.
Chemical & pharmaceutical bulletin 2006;54(10):1418-20.
2006: Daelemans Dirk; Pannecouque Christophe
HIV-1 Rev function as target for antiretroviral drug development.
Current opinion in HIV and AIDS 2006;1(5):388-97.
2006: Ji Lei; Chen Fen-Er; Feng Xiao-Qing; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Non-nucleoside HIV-1 reverse transcriptase inhibitors, Part 7. Synthesis, antiviral activity, and 3D-QSAR investigations of novel 6-(1-naphthoyl) HEPT analogues.
Chemical & pharmaceutical bulletin 2006;54(9):1248-53.
2006: Deng Bo-Liang; Hartman Tracy L; Buckheit Robert W; Pannecouque Christophe; De Clercq Erik; Cushman Mark
Replacement of the metabolically labile methyl esters in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors with isoxazolone, isoxazole, oxazolone, or cyano substituents.
Journal of medicinal chemistry 2006;49(17):5316-23.
2006: Thevissen Karin; François Isabelle E J A; Winderickx Joris; Pannecouque Christophe; Cammue Bruno P A
Ceramide involvement in apoptosis and apoptotic diseases.
Mini reviews in medicinal chemistry 2006;6(6):699-709.
2006: Al-Masoudi Najim A; Al-Soud Yaseen A; Kalogerakis Aris; Pannecouque Christophe; De Clercq Erik
Nitroimidazoles, part 2: Synthesis, antiviral and antitumor activity of new 4-nitroimidazoles.
Chemistry & biodiversity 2006;3(5):515-26.
2006: Stevens Miguel; Pannecouque Christophe; De Clercq Erik; Balzarini Jan
Pyridine N-oxide derivatives inhibit viral transactivation by interfering with NF-kappaB binding.
Biochemical pharmacology 2006;71(8):1122-35.
2006: Deng Bo-Liang; Cullen Matthew D; Zhou Zhigang; Hartman Tracy L; Buckheit Robert W; Pannecouque Christophe; De Clercq Erik; Fanwick Phillip E; Cushman Mark
Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings.
Bioorganic & medicinal chemistry 2006;14(7):2366-74.
2006: Maruyama Tokumi; Kozai Shigetada; Demizu Yosuke; Witvrouw Myriam; Pannecouque Christophe; Balzarini Jan; Snoecks Robert; Andrei Graciella; De Clercq Erik
Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.
Chemical & pharmaceutical bulletin 2006;54(3):325-33.
2006: Griffioen Gerard; Duhamel Hein; Van Damme Nele; Pellens Klaartje; Zabrocki Piotr; Pannecouque Christophe; van Leuven Fred; Winderickx Joris; Wera Stefaan
A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential.
Biochimica et biophysica acta 2006;1762(3):312-8.
2005: Stevens Miguel; Balzarini Jan; Tabarrini Oriana; Andrei Graciela; Snoeck Robert; Cecchetti Violetta; Fravolini Arnaldo; De Clercq Erik; Pannecouque Christophe
Cell-dependent interference of a series of new 6-aminoquinolone derivatives with viral (HIV/CMV) transactivation.
The Journal of antimicrobial chemotherapy 2005;56(5):847-55.
2005: Sun Guang-Fu; Kuang Yun-Yan; Chen Fen-Er; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Non-nucleoside HIV reverse transcriptase inhibitors, Part 6[1]: synthesis and anti-HIV activity of novel 2-[(arylcarbonylmethyl)thio]-6-arylthio DABO analogues.
Archiv der Pharmazie 2005;338(10):457-61.
2005: Deng Bo-Liang; Hartman Tracy L; Buckheit Robert W; Pannecouque Christophe; De Clercq Erik; Fanwick Phillip E; Cushman Mark
Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2005;48(19):6140-55.
2005: Sun Guang-Fu; Chen Xu-Xiang; Chen Fen-Er; Wang Yue-Ping; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Nonnucleoside HIV-1 reverse-transcriptase inhibitors, part 5. Synthesis and anti-HIV-1 activity of novel 6-naphthylthio HEPT analogues.
Chemical & pharmaceutical bulletin 2005;53(8):886-92.
2005: Nguyen Van Nhien Albert; Tomassi Cyrille; Len Christophe; Marco-Contelles José Luis; Balzarini Jan; Pannecouque Christophe; De Clercq Erik; Postel Denis
First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication.
Journal of medicinal chemistry 2005;48(13):4276-84.
2005: Witvrouw Myriam; Fikkert Valery; Hantson Anke; Pannecouque Christophe; O'keefe Barry R; McMahon James; Stamatatos Leonidas; de Clercq Erik; Bolmstedt Anders
Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.
Journal of virology 2005;79(12):7777-84.
2005: Barreca Maria Letizia; Rao Angela; De Luca Laura; Zappalà Maria; Monforte Anna-Maria; Maga Giovanni; Pannecouque Christophe; Balzarini Jan; De Clercq Erik; Chimirri Alba; Monforte Pietro
Computational strategies in discovering novel non-nucleoside inhibitors of HIV-1 RT.
Journal of medicinal chemistry 2005;48(9):3433-7.
2005: Daelemans Dirk; Pannecouque Christophe; Pavlakis George N; Tabarrini Oriana; De Clercq Erik
A novel and efficient approach to discriminate between pre- and post-transcription HIV inhibitors.
Molecular pharmacology 2005;67(5):1574-80.
2005: Wu Tongfei; Froeyen Matheus; Kempeneers Veerle; Pannecouque Christophe; Wang Jing; Busson Roger; De Clercq Erik; Herdewijn Piet
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents.
Journal of the American Chemical Society 2005;127(14):5056-65.
2005: Balzarini Jan; Stevens Miguel; De Clercq Erik; Schols Dominique; Pannecouque Christophe
Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.
The Journal of antimicrobial chemotherapy 2005;55(2):135-8.
2005: De Clercq Erik; Andrei G; Balzarini J; Leyssen P; Naesens L; Neyts J; Pannecouque C; Snoeck R; Ying C; Hocková D; Holý A
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):331-41.
2005: Hantson Anke; Fikkert Valery; Van Remoortel Barbara; Pannecouque Chistophe; Cherepanov Peter; Matthews Barry; Holan George; De Clercq Erik; Vandamme Anne-Mieke; Debyser Zeger; Witvrouw Myriam
Mutations in both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology.
Antiviral chemistry & chemotherapy 2005;16(4):253-66.
2004: He Yanping; Chen Fener; Yu Xiongjie; Wang Yueping; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Nonnucleoside HIV-1 reverse transcriptase inhibitors; part 3. Synthesis and antiviral activity of 5-alkyl-2-[(aryl and alkyloxyl-carbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones.
Bioorganic chemistry 2004;32(6):536-48.
2004: Fikkert Valery; Hombrouck Anneleen; Van Remoortel Barbara; De Maeyer Marc; Pannecouque Christophe; De Clercq Erik; Debyser Zeger; Witvrouw Myriam
Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.
AIDS (London, England) 2004;18(15):2019-28.
2004: Balzarini J; Pannecouque C; Naesens L; Andrei G; Snoeck R; De Clercq E; Hocková D; Holý A
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1321-7.
2004: Tabarrini Oriana; Stevens Miguel; Cecchetti Violetta; Sabatini Stefano; Dell'Uomo Micaela; Manfroni Giuseppe; Palumbo Manlio; Pannecouque Christophe; De Clercq Erik; Fravolini Arnaldo
Structure modifications of 6-aminoquinolones with potent anti-HIV activity.
Journal of medicinal chemistry 2004;47(22):5567-78.
2004: Witvrouw M; Van Maele B; Vercammen J; Hantson A; Engelborghs Y; De Clercq E; Pannecouque C; Debyser Z
Novel inhibitors of HIV-1 integration.
Current drug metabolism 2004;5(4):291-304.
2004: Rao A; Balzarini J; Carbone A; Chimirri A; De Clercq E; Monforte A M; Monforte P; Pannecouque C; Zappalà M
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
Antiviral research 2004;63(2):79-84.
2004: Cutrì Christian C C; Garozzo Adriana; Pannecouque Christophe; Castro Angelo; Guerrera Francesco; De Clercq Erik
Isothiazole derivatives as novel HIV replication inhibitors.
Antiviral chemistry & chemotherapy 2004;15(4):201-5.
2004: Silvestri Maximilian A; Nagarajan Muthukaman; De Clercq Erik; Pannecouque Christophe; Cushman Mark
Design, synthesis, anti-HIV activities, and metabolic stabilities of alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors.
Journal of medicinal chemistry 2004;47(12):3149-62.
2004: He Yanping; Chen Fener; Sun Guangfu; Wang Yueping; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
5-Alkyl-2-[(aryl and alkyloxylcarbonylmethyl)thio]-6-(1-naphthylmethyl) pyrimidin-4(3H)-ones as an unique HIV reverse transcriptase inhibitors of S-DABO series.
Bioorganic & medicinal chemistry letters 2004;14(12):3173-6.
2004: Gagnard Valérie; Leydet Alain; Morère Alain; Montero Jean-Louis; Lefèbvre Isabelle; Gosselin Gilles; Pannecouque Christophe; De Clercq Erick
Synthesis and in vitro evaluation of S-acyl-3-thiopropyl prodrugs of Foscarnet.
Bioorganic & medicinal chemistry 2004;12(6):1393-402.
2004: Witvrouw Myriam; Pannecouque Christophe; Switzer William M; Folks Thomas M; De Clercq Erik; Heneine Walid
Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis.
Antiviral therapy 2004;9(1):57-65.
2004: Anastasi Carole; Hantz Olivier; De Clercq Erik; Pannecouque Christophe; Clayette Pascal; Dereuddre-Bosquet Nathalie; Dormont Dominique; Gondois-Rey Françoise; Hirsch Ivan; Kraus Jean-Louis
Potent nonclassical nucleoside antiviral drugs based on the N,N-diarylformamidine concept.
Journal of medicinal chemistry 2004;47(5):1183-92.
2004: Rao Angela; Balzarini Jan; Carbone Anna; Chimirri Alba; De Clercq Erik; Monforte Anna Maria; Monforte Pietro; Pannecouque Christophe; Zappalà Maria
Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
Farmaco (Società chimica italiana : 1989) 2004;59(1):33-9.
2004: Maruyama Tokumi; Kozai Shigetada; Demizu Yosuke; Witvrouw Myriam; Pannecouque Christophe; Balzarini Jan; Snoeck Robert; Andrei Graciella; De Clercq Erik
Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1.
Nucleic acids symposium series (2004) 2004;(48):3-4.
2004: Taourirte M; Mohamed L Ait; Rochdi A; Vasseur J J; Fernández S; Ferrero M; Gotor V; Pannecouque C; De Clercq E; Lazrek H B
Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity.
Nucleosides, nucleotides & nucleic acids 2004;23(4):701-14.
2004: Jaksa Suzana; Kralj Bogdan; Pannecouque Christophe; Balzarini Jan; De Clercq Erik; Kobe Joze
How a modification (8-aza-3-deaza-2'-deoxyguanosine) influences the quadruplex structure of Hotoda's 6-mer TGGGAG with 5'- and 3'-end modifications.
Nucleosides, nucleotides & nucleic acids 2004;23(1-2):77-88.
2003: Stamatiou George; Foscolos George B; Fytas George; Kolocouris Antonios; Kolocouris Nicolas; Pannecouque Christophe; Witvrouw Myriam; Padalko Elizaveta; Neyts Johan; De Clercq Erik
Heterocyclic rimantadine analogues with antiviral activity.
Bioorganic & medicinal chemistry 2003;11(24):5485-92.
2003: Witvrouw Myriam; Pannecouque Christophe; Fikkert Valery; Hantson Anke; Van Remoortel Barbara; Hezareh Marjan; De Clercq Erik; Brown Stephen J
Potent and selective inhibition of HIV and SIV by prostratin interacting with viral entry.
Antiviral chemistry & chemotherapy 2003;14(6):321-8.
2003: Fikkert Valery; Van Maele Bénédicte; Vercammen Jo; Hantson Anke; Van Remoortel Barbara; Michiels Martine; Gurnari Cristina; Pannecouque Christophe; De Maeyer Marc; Engelborghs Yves; De Clercq Erik; Debyser Zeger; Witvrouw Myriam
Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Journal of virology 2003;77(21):11459-70.
2003: Stevens Miguel; Pannecouque Christophe; De Clercq Erik; Balzarini Jan
Novel human immunodeficiency virus (HIV) inhibitors that have a dual mode of anti-HIV action.
Antimicrobial agents and chemotherapy 2003;47(10):3109-16.
2003: Maruyama Tokumi; Kozai Shigetada; Yamasaki Tetsuo; Witvrouw Myriam; Pannecouque Christophe; Balzarini Jan; Snoeck Robert; Andrei Graciella; De Clercq Erik
Synthesis and antiviral activity of 1,3-disubstituted uracils against HIV-1 and HCMV.
Antiviral chemistry & chemotherapy 2003;14(5):271-9.
2003: Stevens Miguel; Pannecouque Christophe; De Clercq Erik; Balzarini Jan
Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives.
Antimicrobial agents and chemotherapy 2003;47(9):2951-7.
2003: Anastasi Carole; Vlieghe Patrick; Hantz Olivier; Schorr Olivier; Pannecouque Christophe; Witvrouw Myriam; De Clercq Erik; Clayette Pascal; Dereuddre-Bosquet Nathalie; Dormont Dominique; Gondois-Rey Françoise; Hirsch Ivan; Kraus Jean-Louis
Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?
Bioorganic & medicinal chemistry letters 2003;13(15):2459-63.
2003: Galtier Christophe; Mavel Sylvie; Snoeck Robert; Andreï Graciela; Pannecouque Christophe; Witvrouw Myriam; Balzarini Jan; De Clercq Erik; Gueiffier Alain
Synthesis and antiviral activities of 3-aralkylthiomethylimidazo[1,2-b]pyridazine derivatives.
Antiviral chemistry & chemotherapy 2003;14(4):177-82.
2003: Meng Ge; Chen Fen-Er; De Clercq Erik; Balzarini Jan; Pannecouque Christophe
Nonnucleoside HIV-1 reverse transcriptase inhibitors: Part I. Synthesis and structure-activity relationship of 1-alkoxymethyl-5-alkyl-6-naphthylmethyl uracils as HEPT analogues.
Chemical & pharmaceutical bulletin 2003;51(7):779-89.
2003: Balzarini Jan; Pannecouque Christophe; De Clercq Erik; Pavlov Andrey Y; Printsevskaya Svetlana S; Miroshnikova Olga V; Reznikova Marina I; Preobrazhenskaya Maria N
Antiretroviral activity of semisynthetic derivatives of glycopeptide antibiotics.
Journal of medicinal chemistry 2003;46(13):2755-64.
2003: Ait Mohamed L; Taourirte M; Rochdi A; Lazrek H B; Vasseur J J; Engels J W; Pannecouque C; De Clercq E
Synthesis of new homo and heterodimers of 2',3'-dideoxyinosine (ddI) using ester linkages.
Nucleosides, nucleotides & nucleic acids 2003;22(5-8):829-31.
2003: Lagoja Irene M; Pannecouque Christophe; Van Aerschot Arthur; Witvrouw Myriam; Debyser Zeger; Balzarini Jan; Herdewijn Piet; De Clercq Erik
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.
Journal of medicinal chemistry 2003;46(8):1546-53.
2003: Rao Angela; Carbone Anna; Chimirri Alba; De Clercq Erik; Monforte Anna Maria; Monforte Pietro; Pannecouque Christophe; Zappalà Maria
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-ones.
Farmaco (Società chimica italiana : 1989) 2003;58(2):115-20.
2002: Fikkert Valery; Cherepanov Peter; Van Laethem Kristel; Hantson Anke; Van Remoortel Barbara; Pannecouque Christophe; De Clercq Erik; Debyser Zeger; Vandamme Anne-Mieke; Witvrouw Myriam
env chimeric virus technology for evaluating human immunodeficiency virus susceptibility to entry inhibitors.
Antimicrobial agents and chemotherapy 2002;46(12):3954-62.
2002: Barreca Maria L; Balzarini Jan; Chimirri Alba; De Clercq Erik; De Luca Laura; Höltje Hans Dieter; Höltje Monika; Monforte Anna Maria; Monforte Pietro; Pannecouque Christophe; Rao Angela; Zappalà Maria
Design, synthesis, structure-activity relationships, and molecular modeling studies of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV agents.
Journal of medicinal chemistry 2002;45(24):5410-3.
2002: Rao Angela; Chimirri Alba; De Clercq Erik; Monforte Anna Maria; Monforte Pietro; Pannecouque Christophe; Zappalà Maria
Synthesis and anti-hIV activity of 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-a]benzimidazole structurally-related 1,2-substituted benzimidazoles.
Farmaco (Società chimica italiana : 1989) 2002;57(10):819-23.
2002: Pluymers Wim; Pais Godwin; Van Maele Bénédicte; Pannecouque Christophe; Fikkert Valery; Burke Terrence R; De Clercq Erik; Witvrouw Myriam; Neamati Nouri; Debyser Zeger
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives.
Antimicrobial agents and chemotherapy 2002;46(10):3292-7.
2002: Rao Angela; Carbone Anna; Chimirri Alba; De Clercq Erik; Monforte Anna Maria; Monforte Pietro; Pannecouque Christophe; Zappalà Maria
Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.
Farmaco (Società chimica italiana : 1989) 2002;57(9):747-51.
2002: Pannecouque Christophe; Pluymers Wim; Van Maele Bénédicte; Tetz Victor; Cherepanov Peter; De Clercq Erik; Witvrouw Myriam; Debyser Zeger
New class of HIV integrase inhibitors that block viral replication in cell culture.
Current biology : CB 2002;12(14):1169-77.
2002: Balzarini J; Pannecouque C; De Clercq E; Aquaro S; Perno C-F; Egberink H; Holý A
Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.
Antimicrobial agents and chemotherapy 2002;46(7):2185-93.
2002: Salido Sofía; Altarejos Joaquín; Nogueras Manuel; Sánchez Adolfo; Pannecouque Christophe; Witvrouw Myriam; De Clercq Erik
Chemical studies of essential oils of Juniperus oxycedrus ssp. badia.
Journal of ethnopharmacology 2002;81(1):129-34.
2002: Mishra Vibha; Pandeya S N; Pannecouque Christophe; Witvrouw Myriam; De Clercq E
Anti-HIV activity of thiosemicarbazone and semicarbazone derivatives of (+/-)-3-menthone.
Archiv der Pharmazie 2002;335(5):183-6.
2002: Kritsanida Marina; Mouroutsou Anastasia; Marakos Panagiotis; Pouli Nicole; Papakonstantinou-Garoufalias Spyroula; Pannecouque Christophe; Witvrouw Myriam; De Clercq Erik
Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
Farmaco (Società chimica italiana : 1989) 2002;57(3):253-7.
2002: Vlieghe Patrick; Clerc Thierry; Pannecouque Christophe; Witvrouw Myriam; De Clercq Erik; Salles Jean-Pierre; Kraus Jean-Louis
Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities.
Journal of medicinal chemistry 2002;45(6):1275-83.
2002: Kolocouris Antonios; Dimas Kostas; Pannecouque Christophe; Witvrouw Myriam; Foscolos George B; Stamatiou George; Fytas George; Zoidis Grigoris; Kolocouris Nicolas; Andrei Graciela; Snoeck Robert; De Clercq Erik
New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.
Bioorganic & medicinal chemistry letters 2002;12(5):723-7.
2002: Moukha-chafiq Omar; Taha Mohamed Labd; Lazrek Hassan Bihi; Vasseur Jean-Jacques; Pannecouque Christophe; Witvrouw Myriam; De Clercq Erik
Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines.
Farmaco (Società chimica italiana : 1989) 2002;57(1):27-32.
2001: Lazrek H B; Taourirte M; Oulih T; Barascut J L; Imbach J L; Pannecouque C; Witrouw M; De Clercq E
Synthesis and anti-HIV activity of new modified 1,2,3-triazole acyclonucleosides.
Nucleosides, nucleotides & nucleic acids 2001;20(12):1949-60.
2001: Chaouni-Enabdallah A; Galtier C; Allouchi H; Kherbeche A; Chavignon O; Teulade J C; Witvrouw M; Pannecouque C; Snoeck R; Andrei G; Balzarini J; De Clercq E; Fauvelle F; Enguehard C; Gueiffier A
3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents.
Chemical & pharmaceutical bulletin 2001;49(12):1631-5.
2001: Casimiro-Garcia A; De Clercq E; Pannecouque C; Witvrouw M; Loftus T L; Turpin J A; Buckheit R W; Fanwick P E; Cushman M
Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments.
Bioorganic & medicinal chemistry 2001;9(11):2827-41.
2001: Moukha-Hafiq O; Taha M L; Lazrek H B; Vasseur J J; Pannecouque C; Witvrouw M; De Clercq E
Synthesis and biological evaluation of some 4-substituted 1-[1-(4-hydroxybutyl)-1,2,3-triazol-(4 &5)-ylmethyl]-1H-pyrazolo- 13,4-dipyrimidines.
Nucleosides, nucleotides & nucleic acids 2001;20(10-11):1811-21.
2001: Moukha-Chafiq O; Taha M L; Lazrek H B; Pannecouque C; Witvrouw M; De Clercq E; Barascut J L; Imbach J L
Synthesis and biological activity of 4-substituted 1-[1-(2-hydroxyethoxy)-methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines.
Nucleosides, nucleotides & nucleic acids 2001;20(10-11):1797-810.
2001: Vlieghe P; Clerc T; Pannecouque C; Witvrouw M; De Clercq E; Salles J P; Kraus J L
New 3'-azido-3'-deoxythymidin-5'-yl O-(4-hydroxyalkyl or -alkenyl or -alkylepoxide) carbonate prodrugs: synthesis and anti-HIV evaluation.
Journal of medicinal chemistry 2001;44(18):3014-21.
2001: Chaouni-Benabdallah A; Galtier C; Allouchi H; Kherbeche A; Debouzy J C; Teulade J C; Chavignon O; Witvrouw M; Pannecouque C; Balzarini J; de Clercq E; Enguehard C; Gueiffier A
Synthesis of 3-nitrosoimidazo[1,2-a]pyridine derivatives as potential antiretroviral agents.
Archiv der Pharmazie 2001;334(7):224-8.
2001: Barreca M L; Chimirri A; De Luca L; Monforte A M; Monforte P; Rao A; Zappalà M; Balzarini J; De Clercq E; Pannecouque C; Witvrouw M
Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.
Bioorganic & medicinal chemistry letters 2001;11(13):1793-6.
2001: Chimirri A; Monforte P; Rao A; Zappalà M; Monforte A M; De Sarro G; Pannecouque C; Witvrouw M; Balzarini J; De Clercq E
Synthesis, biological activity, pharmacokinetic properties and molecular modelling studies of novel 1H,3H-oxazolo[3,4-a]benzimidazoles: non-nucleoside HIV-1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 2001;12(3):169-74.
2001: Van Laethem K; Witvrouw M; Pannecouque C; Van Remoortel B; Schmit J C; Esnouf R; Kleim J P; Balzarini J; Desmyter J; De Clercq E; Vandamme A M
Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype.
AIDS (London, England) 2001;15(5):553-61.
2001: Vlieghe P; Bihel F; Clerc T; Pannecouque C; Witvrouw M; De Clercq E; Salles J P; Chermann J C; Kraus J L
New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.
Journal of medicinal chemistry 2001;44(5):777-86.
2001: Santhosh K C; Paul G C; De Clercq E; Pannecouque C; Witvrouw M; Loftus T L; Turpin J A; Buckheit R W; Cushman M
Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.
Journal of medicinal chemistry 2001;44(5):703-14.
2001: Varvaresou A; Iakovou K; Filippatos E; Souli C; Calogeropoulou T; Ioannidou I; Kourounakis A P; Pannecouque C; Witvrouw M; Padalko E; Neyts J; De Clercq E; Tsotinis A
Synthesis, antiretroviral and antioxidant evaluation of a series of new benzo[b]furan derivatives.
Arzneimittel-Forschung 2001;51(2):156-62.
2000: Santhosh K C; De Clercq E; Pannecouque C; Witvrouw M; Loftus T L; Turpin J A; Buckheit R W; Cushman M
Anti-HIV activity of a series of cosalane amino acid conjugates.
Bioorganic & medicinal chemistry letters 2000;10(22):2505-8.
2000: Witvrouw M; Fikkert V; Pluymers W; Matthews B; Mardel K; Schols D; Raff J; Debyser Z; De Clercq E; Holan G; Pannecouque C
Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.
Molecular pharmacology 2000;58(5):1100-8.
2000: Paul G C; De Clercq E; Pannecouque C; Witvrouw M; Loftus T L; Turpin J A; Buckheit R W; Cushman M
Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates.
Bioorganic & medicinal chemistry letters 2000;10(18):2149-52.
2000: Pluymers W; Neamati N; Pannecouque C; Fikkert V; Marchand C; Burke T R; Pommier Y; Schols D; De Clercq E; Debyser Z; Witvrouw M
Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.
Molecular pharmacology 2000;58(3):641-8.
2000: Van Vaerenbergh K; Van Laethem K; Albert J; Boucher C A; Clotet B; Floridia M; Gerstoft J; Hejdeman B; Nielsen C; Pannecouque C; Perrin L; Pirillo M F; Ruiz L; Schmit J C; Schneider F; Schoolmeester A; Schuurman R; Stellbrink H J; Stuyver L; Van Lunzen J; Van Remoortel B; Van Wijngaerden E; Vella S; Witvrouw M; Yerly S; De Clercq E; Destmyer J; Vandamme A M
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues.
Antimicrobial agents and chemotherapy 2000;44(8):2109-17.
2000: Witvrouw M; Pannecouque C; Desmyter J; De Clercq E; Andries K
In vitro evaluation of the effect of temporary removal of HIV drug pressure.
Antiviral research 2000;46(3):215-21.
2000: Witvrouw M; Weigold H; Pannecouque C; Schols D; De Clercq E; Holan G
Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.
Journal of medicinal chemistry 2000;43(5):778-83.
2000: Casimiro-Garcia A; De Clercq E; Pannecouque C; Witvrouw M; Stup T L; Turpin J A; Buckheit R W; Cushman M
Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain.
Bioorganic & medicinal chemistry 2000;8(1):191-200.
2000: Daelemans D; Schols D; Witvrouw M; Pannecouque C; Hatse S; van Dooren S; Hamy F; Klimkait T; de Clercq E; VanDamme A M
A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.
Molecular pharmacology 2000;57(1):116-24.
1999: Arranz M E; Díaz J A; Ingate S T; Witvrouw M; Pannecouque C; Balzarini J; De Clercq E; Vega S
Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors.
Bioorganic & medicinal chemistry 1999;7(12):2811-22.
1999: Van Gelder J; Witvrouw M; Pannecouque C; Henson G; Bridger G; Naesens L; De Clercq E; Annaert P; Shafiee M; Van den Mooter G; Kinget R; Augustijns P
Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.
International journal of pharmaceutics 1999;186(2):127-36.
1999: Chimirri A; Grasso S; Monforte P; Rao A; Zappalà M; Monforte A M; Pannecouque C; Witvrouw M; Balzarini J; De Clercq E
Synthesis and biological activity of novel 1H,3H-thiazolo[3,4-a]benzimidazoles: non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.
Antiviral chemistry & chemotherapy 1999;10(4):211-7.
1999: Witvrouw M; Pannecouque C; De Clercq E; Fernández-Alvarez E; Marco J L
Inhibition of human immunodeficiency virus type (HIV-1) replication by some diversely functionalized spirocyclopropyl derivatives.
Archiv der Pharmazie 1999;332(5):163-6.
1999: Pandeya S N; Yogeeswari P; Sriram D; de Clercq E; Pannecouque C; Witvrouw M
Synthesis and screening for anti-HIV activity of some N-Mannich bases of isatin derivatives.
Chemotherapy 1999;45(3):192-6.
1998: Mishra V; Pandeya S N; DeClercq E; Pannecouque C; Witvrouw M
Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.
Pharmaceutica acta Helvetiae 1998;73(4):215-8.
1998: Leydet A; Moullet C; Roque J P; Witvrouw M; Pannecouque C; Andrei G; Snoeck R; Neyts J; Schols D; De Clercq E
Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.
Journal of medicinal chemistry 1998;41(25):4927-32.
1998: Arranz E; Díaz J A; Ingate S T; Witvrouw M; Pannecouque C; Balzarini J; De Clercq E; Vega S
Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.
Journal of medicinal chemistry 1998;41(21):4109-17.
1998: Chimirri A; Grasso S; Monforte A M; Monforte P; Rao A; Zappalà M; Bruno G; Nicolò F; Pannecouque C; Witvrouw M; De Clercq E
Synthesis, structure and in vitro anti-human immunodeficiency virus activity of novel 3-methyl-1H,3H-thiazolo[3,4-a]benzimidazoles.
Antiviral chemistry & chemotherapy 1998;9(5):431-8.
1998: Witvrouw M; Daelemans D; Pannecouque C; Neyts J; Andrei G; Snoeck R; Vandamme A M; Balzarini J; Desmyter J; Baba M; De Clercq E
Broad-spectrum antiviral activity and mechanism of antiviral action of the fluoroquinolone derivative K-12.
Antiviral chemistry & chemotherapy 1998;9(5):403-11.
1998: Witvrouw M; Arranz M E; Pannecouque C; Declercq R; Jonckheere H; Schmit J C; Vandamme A M; Diaz J A; Ingate S T; Desmyter J; Esnouf R; Van Meervelt L; Vega S; Balzarini J; De Clercq E
1,1,3-Trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine (TTD) derivatives: a new class of nonnucleoside human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitors with anti-HIV-1 activity.
Antimicrobial agents and chemotherapy 1998;42(3):618-23.
1998: Esté J A; Cabrera C; Schols D; Cherepanov P; Gutierrez A; Witvrouw M; Pannecouque C; Debyser Z; Rando R F; Clotet B; Desmyter J; De Clercq E
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).
Molecular pharmacology 1998;53(2):340-5.
1997: Daelemans D; Esté J A; Witvrouw M; Pannecouque C; Jonckheere H; Aquaro S; Perno C F; De Clercq E; Vandamme A M
S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation.
Molecular pharmacology 1997;52(6):1157-63.
1997: Balzarini J; Kruining J; Wedgwood O; Pannecouque C; Aquaro S; Perno C F; Naesens L; Witvrouw M; Heijtink R; De Clercq E; McGuigan C
Conversion of 2',3'-dideoxyadenosine (ddA) and 2',3'-didehydro-2',3'-dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus.
FEBS letters 1997;410(2-3):324-8.
1997: Balzarini J; Vahlenkamp T; Egberink H; Hartmann K; Witvrouw M; Pannecouque C; Casara P; Navé J F; De Clercq E
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice.
Antimicrobial agents and chemotherapy 1997;41(3):611-6.
1997: Witvrouw M; Balzarini J; Pannecouque C; Jhaumeer-Laulloo S; Esté J A; Schols D; Cherepanov P; Schmit J C; Debyser Z; Vandamme A M; Desmyter J; Ramadas S R; de Clercq E
SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus.
Antimicrobial agents and chemotherapy 1997;41(2):262-8.
1991: Wigerinck P; Pannecouque C; Snoeck R; Claes P; De Clercq E; Herdewijn P
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
Journal of medicinal chemistry 1991;34(8):2383-9.

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