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Panayotis Pantazis

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Chrisiida Tsimplouli; Costas Demetzos; Margarita Hadzopoulou-Cladaras; Panayotis Pantazis; Kostas Dimas
In vitro activity of dietary flavonol congeners against human cancer cell lines.
Louisa G Mahaira; Panayotis Pantazis; Nikos Sakellaridis; Chrisiida Tsimplouli; Konstantinos Alevizopoulos; Costas Demetzos; Zhiyong Han; Kostas Dimas
The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action.
Kostas Dimas; Sophia Hatziantoniou; James H Wyche; Panayotis Pantazis
A mastic gum extract induces suppression of growth of human colorectal tumor xenografts in immunodeficient mice.

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All Publications

2012: Chrisiida Tsimplouli; Costas Demetzos; Margarita Hadzopoulou-Cladaras; Panayotis Pantazis; Kostas Dimas
In vitro activity of dietary flavonol congeners against human cancer cell lines.
European journal of nutrition 2012;51(2):181-90.
2011: Louisa G Mahaira; Panayotis Pantazis; Nikos Sakellaridis; Chrisiida Tsimplouli; Konstantinos Alevizopoulos; Costas Demetzos; Zhiyong Han; Kostas Dimas
The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action.
European journal of pharmacology 2011;666(1-3):173-82.
2009: Kostas Dimas; Sophia Hatziantoniou; James H Wyche; Panayotis Pantazis
A mastic gum extract induces suppression of growth of human colorectal tumor xenografts in immunodeficient mice.
In vivo (Athens, Greece) 2009;23(1):63-8.
2007: Kostas Dimas; Sophia Hatziantoniou; Sophia Tseleni; Humaira Khan; Aristidis Georgopoulos; Konstantinos Alevizopoulos; James H Wyche; Panayotis Pantazis; Costas Demetzos
Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice.
Apoptosis : an international journal on programmed cell death 2007;12(4):685-94.
2007: Kannan V Balan; Jeffrey Prince; Z Han; Kostas Dimas; M Cladaras; James H Wyche; N M Sitaras; Panayotis Pantazis
Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var. chia.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2007;14(4):263-72.
2007: Constantin Tamvakopoulos; Kostas Dimas; Zacharias D Sofianos; Sophia Hatziantoniou; Zhiyong Han; Zhong-Li Liu; James H Wyche; Panayotis Pantazis
Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(4):1269-77.
2007: Constantin Tamvakopoulos; Zacharias D Sofianos; Spiros D Garbis; Panayotis Pantazis
Analysis of the in vitro metabolites of diferuloylmethane (curcumin) by liquid chromatography--tandem mass spectrometry on a hybrid quadrupole linear ion trap system: newly identified metabolites.
European journal of drug metabolism and pharmacokinetics 2007;32(1):51-7.
2006: Kannan V Balan; Yongbao Wang; Siming W Chen; Jin-Chun Chen; Li-Fang Zheng; Li Yang; Zhong-Li Liu; Panayotis Pantazis; James H Wyche; Zhiyong Han
Proteasome-independent down-regulation of estrogen receptor-alpha (ERalpha) in breast cancer cells treated with 4,4'-dihydroxy-trans-stilbene.
Biochemical pharmacology 2006;72(5):573-81.
2006: Kannan V Balan; Yongbao Wang; Siming W Chen; Panayotis Pantazis; James H Wyche; Zhiyong Han
Down-regulation of estrogen receptor-alpha in MCF-7 human breast cancer cells after proteasome inhibition.
Biochemical pharmacology 2006;72(5):566-72.
2006: Kostas Dimas; magdalini papadaki; C Tsimplouli; Sophia Hatziantoniou; K Alevizopoulos; Panayotis Pantazis; Costas Demetzos
Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2006;60(3):127-33.
2006: Kannan V Balan; N M Sitaras; Kostas Dimas; Z Han; James H Wyche; Panayotis Pantazis
Differential susceptibility to etoposide in clones derived from a human ovarian cancer cell line.
Chemotherapy 2006;52(3):137-46.
2005: Yongbao Wang; Bo Wang; Jinchun Cheng; Li Yang; Zhong-Li Liu; Kannan V Balan; Panayotis Pantazis; James H Wyche; Zhiyong Han
FADD-dependent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene.
Biochemical pharmacology 2005;69(2):249-54.
2005: Kannan V Balan; Costas Demetzos; Jeffrey Prince; Kostas Dimas; Margarita Cladaras; Zhiyong Han; James H Wyche; Panayotis Pantazis
Induction of apoptosis in human colon cancer HCT116 cells treated with an extract of the plant product, Chios mastic gum.
In vivo (Athens, Greece) 2005;19(1):93-102.
2004: Devasis Chatterjee; Melissa Goldman; Corey D Braastad; James W Darnowski; James H Wyche; Panayotis Pantazis; Lee Goodglick
Reduction of 9-nitrocamptothecin-triggered apoptosis in DU-145 human prostate cancer cells by ectopic expression of 14-3-3zeta.
International journal of oncology 2004;25(2):503-9.
2004: Devasis Chatterjee; Yin Bai; zhe wang; Sandy Beach; Stephanie Mott; Rajat Roy; Corey D Braastad; Yaping Sun; Asok Mukhopadhyay; Bharat B Aggarwal; James W Darnowski; Panayotis Pantazis; James H Wyche; Zheng Fu; Yasuhide Kitagwa; Evan T Keller; John M Sedivy; Kam C Yeung
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis.
The Journal of biological chemistry 2004;279(17):17515-23.
2003: Panayotis Pantazis; Zhiyong Han; Kannan V Balan; Yongbao Wang; James H Wyche
Camptothecin and 9-nitrocamptothecin (9NC) as anti-cancer, anti-HIV and cell-differentiation agents. Development of resistance, enhancement of 9NC-induced activities and combination treatments in cell and animal models.
Anticancer research 2003;23(5A):3623-38.
2003: Xiaolan Hu; Kannan V Balan; Noemi Ramos-DeSimone; James H Wyche; Zhiyong Han; Panayotis Pantazis
Differential susceptibility to 9-nitrocamptothecin (9-NC)-induced apoptosis in clones derived from a human ovarian cancer cell line: possible implications in the treatment of ovarian cancer patients with 9-NC.
Anti-cancer drugs 2003;14(6):427-36.
2002: Zhiyong Han; Iole Ribbizi; Panayotis Pantazis; James H Wyche; James W Darnowski; Paul Calabresi
The antibacterial drug taurolidine induces apoptosis by a mitochondrial cytochrome c-dependent mechanism.
Anticancer research 2002;22(4):1959-64.
2002: Zhiyong Han; Wenyi Wei; Stephen Dunaway; James W Darnowski; Paul Calabresi; John M Sedivy; Eric A Hendrickson; Kannan V Balan; Panayotis Pantazis; James H Wyche
Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin.
The Journal of biological chemistry 2002;277(19):17154-60.
2001: Zhiyong Han; Panayotis Pantazis; James H Wyche; Nicola Kouttab; V J Kidd; Eric A Hendrickson
A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line.
The Journal of biological chemistry 2001;276(42):38748-54.
2001: Devasis Chatterjee; Ingo Schmitz; Andreas Krueger; Kam Yeung; Sabine Kirchhoff; Peter H Krammer; Marcus E Peter; James H Wyche; Panayotis Pantazis
Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short).
Cancer research 2001;61(19):7148-54.
2001: Zhiyong Han; James H Wyche; Howard Sands; Panayotis Pantazis
9-Nitrocamptothecin is an effective drug for the treatment of human lung tumors: comparison of in vitro and in vivo studies.
Anticancer research 2001;21(3B):1823-7.
2000: D Chatterjee; James H Wyche; Panayotis Pantazis
Up-regulation of cyclin B1 and cdc2 expression during 9-nitrocamptothecin-induced regression of DU145 prostate tumor.
Anticancer research 2000;20(6B):4477-82.
2000: D Chatterjee; James H Wyche; D P Romero; Panayotis Pantazis
Telomerase activity, Myc and Bcl-2: possible indicators of effective therapy of prostate cancer with 9-nitrocamptothecin.
Anticancer research 2000;20(5A):2885-9.
2000: Devasis Chatterjee; Panayotis Pantazis; G Li; TA Bremner; Eric A Hendrickson; James H Wyche
Susceptibility to apoptosis is restored in human leukemia HCW-2 cells following induction and stabilization of the apoptotic effector Bak.
Oncogene 2000;19(36):4108-16.
2000: Zhiyong Han; Panayotis Pantazis; T S Lange; James H Wyche; Eric A Hendrickson
The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C.
Cell death and differentiation 2000;7(6):521-30.
1999: Panayotis Pantazis; D Chatterjee; Zhiyong Han; James H Wyche
Differentiation of human malignant melanoma cells that escape apoptosis after treatment with 9-nitrocamptothecin in vitro.
Neoplasia (New York, N.Y.) 1999;1(3):231-40.
1999: Z Han; Z Cao; D Chatterjee; James H Wyche; Panayotis Pantazis
Propionate and butyrate esters of camptothecin and 9-nitrocamptothecin as antileukemia prodrugs in vitro.
European journal of haematology 1999;62(4):246-55.
1999: Panayotis Pantazis; Zhiyong Han; James H Wyche
Schedule-dependent efficiency of thermochemotherapy in vitro with etoposide and heating at 43 degrees C.
Anticancer research 1999;19(2A):995-8.
1999: Panayotis Pantazis; D Chatterjee; Z Han; James H Wyche
Modulation of 9-nitrocamptothecin-induced apoptosis by hyperthermia in human leukemia HL-60 cells.
Anti-cancer drugs 1999;10(3):317-22.
1999: Zhiyong Han; Kapil N Bhalla; Panayotis Pantazis; Eric A Hendrickson; James H Wyche
Cif (Cytochrome c efflux-inducing factor) activity is regulated by Bcl-2 and caspases and correlates with the activation of Bid.
Molecular and cellular biology 1999;19(2):1381-9.
1999: Panayotis Pantazis; Z Han; D Chatterjee; James H Wyche
Water-insoluble camptothecin analogues as potential antiviral drugs.
Journal of biomedical science 1999;6(1):1-7.
1997: Devasis Chatterjee; Z Han; J Mendoza; Lee Goodglick; Eric A Hendrickson; Panayotis Pantazis; James H Wyche
Monocytic differentiation of HL-60 promyelocytic leukemia cells correlates with the induction of Bcl-xL.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(10):1083-9.
1996: D Chatterjee; James H Wyche; Panayotis Pantazis
Induction of apoptosis in malignant and camptothecin-resistant human cells.
Annals of the New York Academy of Sciences 1996;803():143-56.
1996: Panayotis Pantazis; D Chatterjee; James H Wyche; A DeJesus; J Early; S Plaschke; Beppino C Giovanella
Establishment of human prostate tumor xenografts in nude mice and response to 9-nitrocamptothecin in vivo and in vitro does not correlate with the expression of various apoptosis-regulating proteins.
Journal of experimental therapeutics & oncology 1996;1(5):322-33.
1996: Panayotis Pantazis; D Chatterjee; Z Han; James H Wyche; A DeJesus; Beppino C Giovanella
Monocytic differentiation and synthesis of proteins associated with apoptosis in human leukemia U-937 cells acquiring resistance to vincristine.
European journal of haematology 1996;57(1):79-86.
1996: Zhiyong Han; D Chatterjee; J Early; Panayotis Pantazis; Eric A Hendrickson; James H Wyche
Isolation and characterization of an apoptosis-resistant variant of human leukemia HL-60 cells that has switched expression from Bcl-2 to Bcl-xL.
Cancer research 1996;56(7):1621-8.
1995: Panayotis Pantazis
The water-insoluble camptothecin analogues: promising drugs for the effective treatment of haematological malignancies.
Leukemia research 1995;19(11):775-88.
1995: Zhiyong Han; D Chatterjee; DM He; J Early; Panayotis Pantazis; James H Wyche; Eric A Hendrickson
Evidence for a G2 checkpoint in p53-independent apoptosis induction by X-irradiation.
Molecular and cellular biology 1995;15(11):5849-57.
1995: Panayotis Pantazis; A Dejesus; J Early; R Rodriguez; D Chatterjee; Z Han; James H Wyche; Beppino C Giovanella
Development of human leukemia U-937 cell sublines resistant to doxorubicin: induction of differentiation and altered sensitivities to topoisomerase-directed drugs.
Anticancer research 1995;15(5B):1873-81.
1995: Panayotis Pantazis; N Harris; J Mendoza; Beppino C Giovanella
The role of pH and serum albumin in the metabolic conversion of 9-nitrocamptothecin to 9-aminocamptothecin by human hematopoietic and other cells.
European journal of haematology 1995;55(3):211-3.
1995: Panayotis Pantazis; D Vardeman; J Mendoza; J Early; A Kozielski; A DeJesus; Beppino C Giovanella
Sensitivity of camptothecin-resistant human leukemia cells and tumors to anticancer drugs with diverse mechanisms of action.
Leukemia research 1995;19(1):43-55.
1994: Panayotis Pantazis; N Harris; J Mendoza; Beppino C Giovanella
Conversion of 9-nitro-camptothecin to 9-amino-camptothecin by human blood cells in vitro.
European journal of haematology 1994;53(4):246-8.
1994: Panayotis Pantazis; J T Mendoza; A DeJesus; E Rubin; Donald Kufe; Beppino C Giovanella
Partial characterization of human leukemia U-937 cell sublines resistant to 9-nitrocamptothecin.
European journal of haematology 1994;53(3):135-44.
1994: Panayotis Pantazis; J Mendoza; A DeJesus; J Early; M Shaw; Beppino C Giovanella
Development of resistance to 9-nitro-camptothecin by human leukemia U-937 cells in vitro correlates with altered sensitivities to several anticancer drugs.
Anti-cancer drugs 1994;5(4):473-9.
1994: Panayotis Pantazis; J A Early; J T Mendoza; A R DeJesus; Beppino C Giovanella
Cytotoxic efficacy of 9-nitrocamptothecin in the treatment of human malignant melanoma cells in vitro.
Cancer research 1994;54(3):771-6.
1994: Panayotis Pantazis; A Kozielski; R Rodriguez; E Petry; M Wani; M Wall; Beppino C Giovanella
Therapeutic efficacy of camptothecin derivatives against human malignant melanoma xenografts.
Melanoma research 1994;4(1):5-10.
1994: E Rubin; Panayotis Pantazis; Ajit Bharti; D Toppmeyer; B Giovanella; Donald Kufe
Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin.
The Journal of biological chemistry 1994;269(4):2433-9.
1993: Panayotis Pantazis; J A Early; A J Kozielski; J T Mendoza; H R Hinz; Beppino C Giovanella
Regression of human breast carcinoma tumors in immunodeficient mice treated with 9-nitrocamptothecin: differential response of nontumorigenic and tumorigenic human breast cells in vitro.
Cancer research 1993;53(7):1577-82.
1993: Panayotis Pantazis; A J Kozielski; J T Mendoza; J A Early; H R Hinz; Beppino C Giovanella
Camptothecin derivatives induce regression of human ovarian carcinomas grown in nude mice and distinguish between non-tumorigenic and tumorigenic cells in vitro.
International journal of cancer. Journal international du cancer 1993;53(5):863-71.
1993: Panayotis Pantazis; J T Mendoza; J A Early; A J Kozielski; E A Natelson; Beppino C Giovanella
9-Nitro-camptothecin delays growth of U-937 leukemia tumors in nude mice and is cytotoxic or cytostatic for human myelomonocytic leukemia lines in vitro.
European journal of haematology 1993;50(2):81-9.
1993: Panayotis Pantazis; A J Kozielski; D M Vardeman; E R Petry; Beppino C Giovanella
Efficacy of camptothecin congeners in the treatment of human breast carcinoma xenografts.
Oncology research 1993;5(8):273-81.
1992: Panayotis Pantazis; H R Hinz; J T Mendoza; A J Kozielski; L J Williams; John S Stehlin; Beppino C Giovanella
Complete inhibition of growth followed by death of human malignant melanoma cells in vitro and regression of human melanoma xenografts in immunodeficient mice induced by camptothecins.
Cancer research 1992;52(14):3980-7.
1991: S Kharbanda; E Rubin; H Gunji; H Hinz; B Giovanella; Panayotis Pantazis; Donald Kufe
Camptothecin and its derivatives induce expression of the c-jun protooncogene in human myeloid leukemia cells.
Cancer research 1991;51(24):6636-42.
1991: Panayotis Pantazis; S Kharbanda; Anton Goustin; T Galanopoulos; Donald Kufe
Coexpression of the genes for platelet-derived growth factor B-chain receptor and macrophage colony-stimulating factor 1 receptor during monocytic differentiation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(6):2481-5.
1990: Panayotis Pantazis; Anton Goustin; J Nixon
Platelet-derived growth factor and its receptor in blood cell differentiation and neoplasia.
European journal of haematology 1990;45(3):127-38.
1990: Anton Goustin; T Galanopoulos; V S Kalyanaraman; Panayotis Pantazis
Coexpression of the genes for platelet-derived growth factor and its receptor in human T-cell lines infected with HTLV-I.
Growth factors (Chur, Switzerland) 1990;2(2-3):189-95.
1989: E Sariban; K Imamura; M Sherman; V Rothwell; Panayotis Pantazis; Donald Kufe
Downregulation of c-fms gene expression in human monocytes treated with phorbol esters and colony-stimulating factor 1.
Blood 1989;74(1):123-9.
1988: E Sariban; N M Sitaras; H N Antoniades; Donald Kufe; Panayotis Pantazis
Expression of platelet-derived growth factor (PDGF)-related transcripts and synthesis of biologically active PDGF-like proteins by human malignant epithelial cell lines.
The Journal of clinical investigation 1988;82(4):1157-64.
1988: N M Sitaras; E Sariban; M Bravo; Panayotis Pantazis; H N Antoniades
Constitutive production of platelet-derived growth factor-like proteins by human prostate carcinoma cell lines.
Cancer research 1988;48(7):1930-5.
1987: N M Sitaras; E Sariban; Panayotis Pantazis; B Zetter; H N Antoniades
Human iliac artery endothelial cells express both genes encoding the chains of platelet-derived growth factor (PDGF) and synthesize PDGF-like mitogen.
Journal of cellular physiology 1987;132(2):376-80.
1987: Panayotis Pantazis; E Sariban; C A Bohan; H N Antoniades; V S Kalyanaraman
Synthesis of PDGF by cultured human T cells transformed with HTLV-I and II.
Oncogene 1987;1(3):285-9.