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William Pao

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Ken Takezawa; Valentina Pirazzoli; Katerina Politi; Gregory J Riely; Xiaoling Song; Paula J Spitzler; Maria E Arcila; Elisa de Stanchina; Yelena Y Janjigian; Mark G Kris; Marc Ladanyi; Mary Ann Melnick; Vincent A Miller; Caroline A Nebhan; Kadoaki Ohashi; William Pao
HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation.
Geoffrey R Oxnard; William Pao; Mark E Robson; Christopher G Azzoli; Marc Ladanyi; Vincent A Miller; Maria E Arcila
Screening for germline EGFR T790M mutations through lung cancer genotyping.
Juliann Chmielecki; Katherine Hutchinson; Mark G Kris; Vincent Miller; M Catherine Pietanza; Naiyer Rizvi; Ronglai Shen; Thomas Stout; Agnes Viale; Zhiguo Zhao; Dana Aftab; Xi Chen; William Pao
EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib.

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2012: Ken Takezawa; Valentina Pirazzoli; Katerina Politi; Gregory J Riely; Xiaoling Song; Paula J Spitzler; Maria E Arcila; Elisa de Stanchina; Yelena Y Janjigian; Mark G Kris; Marc Ladanyi; Mary Ann Melnick; Vincent A Miller; Caroline A Nebhan; Kadoaki Ohashi; William Pao
HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation.
Cancer discovery 2012;2(10):922-33.
2012: Geoffrey R Oxnard; William Pao; Mark E Robson; Christopher G Azzoli; Marc Ladanyi; Vincent A Miller; Maria E Arcila
Screening for germline EGFR T790M mutations through lung cancer genotyping.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(6):1049-52.
2012: Juliann Chmielecki; Katherine Hutchinson; Mark G Kris; Vincent Miller; M Catherine Pietanza; Naiyer Rizvi; Ronglai Shen; Thomas Stout; Agnes Viale; Zhiguo Zhao; Dana Aftab; Xi Chen; William Pao
EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2012;7(2):434-42.
2012: Juliann Chmielecki; Utpal P Davé; Rebecca S Dean; Jennifer Giltnane; Clayton J Hollis; Katherine Hutchinson; Madan Jagasia; Annette S Kim; Martin Peifer; Nicholas D Socci; Roman K Thomas; Agnes Viale; Ashwini Yenamandra; William Pao
Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm.
Genes, chromosomes & cancer 2012;51(1):54-65.
2012: Yixuan Gong; William Pao
EGFR mutant lung cancer.
Current topics in microbiology and immunology 2012;355():59-81.
2011: Christian Grommes; Andrei I Holodny; Mark G Kris; Vincent A Miller; Geoffrey R Oxnard; William Pao; Jennifer L Clarke; Andrew B Lassman
"Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer.
Neuro-oncology 2011;13(12):1364-9.
2011: Juliann Chmielecki; Elisa de Stanchina; Jasmine Foo; Michelle S Ginsberg; Katherine Hutchinson; Akira Inoue; Mark G Kris; Marc Ladanyi; Franziska Michor; Vincent A Miller; Kadoaki Ohashi; Geoffrey R Oxnard; Nicholas D Socci; Romel Somwar; Martin L Sos; Roman K Thomas; Agnes Viale; Lu Wang; Katherine R Amato; Maria Arcila; William Pao
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.
Science translational medicine 2011;3(90):90ra59.
2010: Binsheng Zhao; Geoffrey R Oxnard; Chaya S Moskowitz; Mark G Kris; William Pao; Pingzhen Guo; Valerie M Rusch; Marc Ladanyi; Naiyer A Rizvi; Lawrence H Schwartz
A pilot study of volume measurement as a method of tumor response evaluation to aid biomarker development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(18):4647-53.
2010: Jennifer L Clarke; William Pao; Nian Wu; Vincent A Miller; Andrew B Lassman
High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer.
Journal of neuro-oncology 2010;99(2):283-6.
2010: Elizabeth F Redente; Lori D Dwyer-Nield; Daniel T Merrick; Komal Raina; Rajesh Agarwal; William Pao; Pamela L Rice; Kenneth R Shroyer; Alvin M Malkinson
Tumor progression stage and anatomical site regulate tumor-associated macrophage and bone marrow-derived monocyte polarization.
The American journal of pathology 2010;176(6):2972-85.
2010: Christopher G Azzoli; Sherman Baker; Sarah Temin; William Pao; Timothy Aliff; Julie R Brahmer; David H Johnson; Janessa L Laskin; Gregory Masters; Daniel Milton; Luke Nordquist; David G Pfister; Steven Piantadosi; Joan H Schiller; Reily Smith; Thomas J Smith; John R Strawn; David Trent; Giuseppe Giaccone
[American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2010;13(3):171-89.
2010: Nicolas Girard; Emil Lou; Christopher G Azzoli; Rekha Reddy; Mark Robson; Megan Harlan; Irene Orlow; Yasushi Yatabe; Khedoudja Nafa; Marc Ladanyi; Agnes Viale; Mark G Kris; Gregory J Riely; Vincent A Miller; Robert J. Klein; Keitaro Matsuo; William Pao
Analysis of genetic variants in never-smokers with lung cancer facilitated by an Internet-based blood collection protocol: a preliminary report.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(2):755-63.
2010: Stephen B Solomon; Maureen F Zakowski; William Pao; Raymond H Thornton; Marc Ladanyi; Mark G Kris; Valerie W Rusch; Naiyer A Rizvi
Core needle lung biopsy specimens: adequacy for EGFR and KRAS mutational analysis.
AJR. American journal of roentgenology 2010;194(1):266-9.
2010: Selvaraju Veeriah; Barry S Taylor; Shasha Meng; Fang Fang; Emrullah Yilmaz; Igor Vivanco; Manickam Janakiraman; Nikolaus Schultz; Aphrothiti J Hanrahan; William Pao; Marc Ladanyi; Chris Sander; Adriana Heguy; Eric C Holland; Philip B Paty; Paul Mischel; Linda Liau; Timothy F Cloughesy; Ingo K Mellinghoff; David B Solit; Timothy Chan
Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies.
Nature genetics 2010;42(1):77-82.
2010: Nicolas Girard; Charuhas Deshpande; Christopher G Azzoli; Valerie W Rusch; William D Travis; Marc Ladanyi; William Pao
Use of epidermal growth factor receptor/Kirsten rat sarcoma 2 viral oncogene homolog mutation testing to define clonal relationships among multiple lung adenocarcinomas: comparison with clinical guidelines.
Chest 2010;137(1):46-52.
2009: Nicolas Girard; Charuhas Deshpande; Christopher Lau; David John Finley; Valerie W Rusch; William Pao; William D Travis
Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.
The American journal of surgical pathology 2009;33(12):1752-64.
2009: Nicolas Girard; Ronglai Shen; Tianhua Guo; Maureen F Zakowski; Adriana Heguy; Gregory J Riely; James Huang; Christopher Lau; Alex E Lash; Marc Ladanyi; Agnes Viale; Cristina R Antonescu; William D Travis; Valerie W Rusch; Mark G Kris; William Pao
Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(22):6790-9.
2009: Lucia Regales; Yixuan Gong; Ronglai Shen; Elisa de Stanchina; Igor Vivanco; Aviva Goel; Jason A Koutcher; Maria Spassova; Ouathek Ouerfelli; Ingo K Mellinghoff; Maureen F Zakowski; Katerina A Politi; William Pao
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer.
The Journal of clinical investigation 2009;119(10):3000-10.
2009: William Pao; Mark G Kris; A John Iafrate; Marc Ladanyi; Pasi A Janne; Ignacio I Wistuba; Ryn Miake-Lye; Roy S Herbst; David P Carbone; Bruce E Johnson; Thomas J Lynch
Integration of molecular profiling into the lung cancer clinic.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(17):5317-22.
2009: Nicolas Girard; Irina Ostrovnaya; Christopher Lau; Bernard J Park; Marc Ladanyi; David John Finley; Charuhas Deshpande; Valerie W Rusch; Irene Orlow; William D Travis; William Pao; Colin B Begg
Genomic and mutational profiling to assess clonal relationships between multiple non-small cell lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(16):5184-90.
2009: Dhananjay A Chitale; Yixuan Gong; B S Taylor; S Broderick; Cameron Brennan; Romel Somwar; B Golas; Liang Wang; N Motoi; J Szoke; J M Reinersman; J Major; Chris Sander; Venkatraman E Seshan; Maureen F Zakowski; Valerie W Rusch; William Pao; William Gerald; Marc Ladanyi
An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors.
Oncogene 2009;28(31):2773-83.
2009: Selvaraju Veeriah; Cameron Brennan; Shasha Meng; Bhuvanesh Singh; James A Fagin; David B Solit; Philip B Paty; Dan Rohle; Igor Vivanco; Juliann Chmielecki; William Pao; Marc Ladanyi; William L Gerald; Linda Liau; Timothy C Cloughesy; Paul Mischel; Chris Sander; Barry Taylor; Nikolaus Schultz; John Major; Adriana Heguy; Fang Fang; Ingo K Mellinghoff; Timothy Chan
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(23):9435-40.
2009: Gregory J Riely; Jenifer Marks; William Pao
KRAS mutations in non-small cell lung cancer.
Proceedings of the American Thoracic Society 2009;6(2):201-5.
2009: Yixuan Gong; Evelyn Yao; Ronglai Shen; Aviva Goel; Maria Arcila; Julie T Feldstein; Maureen F Zakowski; Stanley Frankel; Martin Peifer; Roman K Thomas; Marc Ladanyi; William Pao
High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507).
PloS one 2009;4(10):e7273.
2008: Christine A Pratilas; Aphrothiti J Hanrahan; Ensar Halilovic; Yogindra Persaud; Junichi Soh; Dhananjay Chitale; Hisayuki Shigematsu; Hiromasa Yamamoto; Ayana Sawai; Manickam Janakiraman; Barry S Taylor; William Pao; Shinichi Toyooka; Marc Ladanyi; Adi Gazdar; Neal Rosen; David B Solit
Genetic predictors of MEK dependence in non-small cell lung cancer.
Cancer research 2008;68(22):9375-83.
2008: Gregory J Riely; Mark G Kris; Daniel Rosenbaum; Jenifer Marks; Allan Li; Dhananjay A Chitale; Khedoudja Nafa; Elyn Riedel; Meier Hsu; William Pao; Vincent A Miller; Marc Ladanyi
Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(18):5731-4.
2008: Jenifer L Marks; Yixuan Gong; Dhananjay Chitale; Ben Golas; Michael D McLellan; Yumi Kasai; Li Ding; Elaine R Mardis; Richard K Wilson; David B Solit; Ross Levine; Kathrin Michel; Roman K Thomas; Valerie W Rusch; Marc Ladanyi; William Pao
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma.
Cancer research 2008;68(14):5524-8.
2008: Yelena Lyustikman; Hiroyuki Momota; William Pao; Eric C Holland
Constitutive activation of Raf-1 induces glioma formation in mice.
Neoplasia (New York, N.Y.) 2008;10(5):501-10.
2008: Marc Ladanyi; William Pao
Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008;21 Suppl 2():S16-22.
2008: Allan R Li; Dhananjay Chitale; Gregory J Riely; William Pao; Vincent A Miller; Maureen F Zakowski; Valerie W Rusch; Mark G Kris; Marc Ladanyi
EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression.
The Journal of molecular diagnostics : JMD 2008;10(3):242-8.
2008: Vincent A Miller; Gregory J Riely; Maureen F Zakowski; Allan R Li; Jyoti D Patel; Robert T Heelan; Mark G Kris; Alan B Sandler; David P Carbone; Anne Tsao; Roy S Herbst; Glenn Heller; Marc Ladanyi; William Pao; David H Johnson
Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(9):1472-8.
2008: Jenifer L Marks; Stephen Broderick; Qin Zhou; Dhananjay Chitale; Allan R Li; Maureen F Zakowski; Mark G Kris; Valerie W Rusch; Christopher G Azzoli; Venkatraman E Seshan; Marc Ladanyi; William Pao
Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(2):111-6.
2008: Christopher G Azzoli; Bernard J Park; William Pao; Maureen F Zakowski; Mark G Kris
Molecularly tailored adjuvant chemotherapy for resected non-small cell lung cancer: a time for excitement and equipoise.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2008;3(1):84-93.
2007: James Bean; Cameron Brennan; Jin-Yuan Shih; Gregory J Riely; Agnes Viale; Lu Wang; Dhananjay Chitale; Noriko Motoi; Janos Szoke; Stephen Broderick; Marissa N Balak; Wen-Cheng Chang; Chong-Jen Yu; Adi F Gazdar; Harvey I Pass; Valerie W Rusch; William Gerald; Shiu-Feng Huang; Pan-Chyr Yang; Vincent A Miller; Marc Ladanyi; Chih-Hsin Yang; William Pao
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20932-7.
2007: Sizhi Paul Gao; Kevin G Mark; Kenneth Leslie; William Pao; Noriko Motoi; William L Gerald; William D Travis; William G Bornmann; Darren R Veach; Bayard Clarkson; Jacqueline F Bromberg
Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas.
The Journal of clinical investigation 2007;117(12):3846-56.
2007: Yixuan Gong; Romel Somwar; Katerina Politi; Marissa N Balak; Juliann Chmielecki; Xuejun Jiang; William Pao
Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas.
PLoS medicine 2007;4(10):e294.
2007: Gregory J Riely; Mark G Kris; Binsheng Zhao; Timothy Akhurst; Daniel T Milton; Erin Moore; Leslie Tyson; William Pao; Naiyer A Rizvi; Lawrence H Schwartz; Vincent A Miller
Prospective assessment of discontinuation and reinitiation of erlotinib or gefitinib in patients with acquired resistance to erlotinib or gefitinib followed by the addition of everolimus.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(17):5150-5.
2007: Daniel T Milton; Gregory J Riely; Christopher G Azzoli; Jorge Gomez; Robert T Heelan; Mark G Kris; Lee M Krug; William Pao; Barbara Pizzo; Naiyer A Rizvi; Vincent A Miller
Phase 1 trial of everolimus and gefitinib in patients with advanced nonsmall-cell lung cancer.
Cancer 2007;110(3):599-605.
2007: Lucia Regales; Marissa N Balak; Yixuan Gong; Katerina Politi; Ayana Sawai; Carl Le; Jason A Koutcher; David B Solit; Neal Rosen; Maureen F Zakowski; William Pao
Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors.
PloS one 2007;2(8):e810.
2007: Jenifer L Marks; Michael D McLellan; Maureen F Zakowski; Alex E Lash; Yumi Kasai; Stephen Broderick; Inderpal S Sarkaria; Duykhanh Pham; Bhuvanesh Singh; Tracie L Miner; Ginger A Fewell; Lucinda L Fulton; Elaine R Mardis; Richard K Wilson; Mark G Kris; Valerie W Rusch; Harold Varmus; William Pao
Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.
PloS one 2007;2(5):e426.
2006: Gregory J Riely; Katerina Politi; Vincent A Miller; William Pao
Update on epidermal growth factor receptor mutations in non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7232-41.
2006: David C Christiani; William Pao; James DeMartini; R Ilona Linnoila; Alvin M Malkinson; Amir Onn; Katerina Politi; Michael Sharp; Kwok-Kin Wong; Kwok Kim
BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2006;1(9 Suppl):S2-7.
2006: William Pao
Defining clinically relevant molecular subsets of lung cancer.
Cancer chemotherapy and pharmacology 2006;58 Suppl 1():s11-5.
2006: Marissa N Balak; Yixuan Gong; Gregory J Riely; Romel Somwar; Allan R Li; Maureen F Zakowski; Anne Chiang; Guangli Yang; Ouathek Ouerfelli; Mark G Kris; Marc Ladanyi; Vincent A Miller; William Pao
Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(21):6494-501.
2006: Daniel T Milton; Gregory J Riely; William Pao; Vincent A Miller; Mark G Kris; Robert T Heelan
Molecular on/off switch.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(30):4940-2.
2006: Daniel T Milton; Christopher G Azzoli; Robert T Heelan; Venkatraman E Seshan; Jorge Gomez; Mark G Kris; Lee M Krug; William Pao; Naiyer A Rizvi; Megan Dunne; Vincent A Miller
A phase I/II study of weekly high-dose erlotinib in previously treated patients with nonsmall cell lung cancer.
Cancer 2006;107(5):1034-41.
2006: Katerina Politi; Maureen F Zakowski; Pang-Dian Fan; Emily A Schonfeld; William Pao; Harold Varmus
Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors.
Genes & development 2006;20(11):1496-510.
2006: Duykhanh Pham; Mark G Kris; Gregory J Riely; Inderpal S Sarkaria; Tiffani McDonough; Shaokun Chuai; Venkatraman E Seshan; Vincent A Miller; Marc Ladanyi; William Pao; Richard K Wilson; Bhuvanesh Singh; Valerie W Rusch
Use of cigarette-smoking history to estimate the likelihood of mutations in epidermal growth factor receptor gene exons 19 and 21 in lung adenocarcinomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(11):1700-4.
2006: Gregory J Riely; William Pao; Duykhanh Pham; Allan R Li; Naiyer A Rizvi; Venkatraman E Seshan; Maureen F Zakowski; Mark G Kris; Marc Ladanyi; Vincent A Miller
Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 1):839-44.
2005: Andrew B Lassman; Michael R Rossi; Jeffrey J Raizer; Jeffrey R Razier; Lauren E Abrey; Frank S Lieberman; Chelsea N Grefe; Kathleen R Lamborn; William Pao; Alan H Shih; John Kuhn; Richard Wilson; Norma J Nowak; John Kenneth Cowell; Lisa De Angelis; Patrick Y Wen; Mark R Gilbert; Susan Chang; W A Yung; Michael Prados; Eric C Holland
Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(21):7841-50.
2005: Gregory J Riely; William Pao
Combining EGFR targeted therapy with chemotherapy in pancreatic cancer: is timing important?
Cancer biology & therapy 2005;4(10):1096-7.
2005: Todd A Carter; Lisa M Wodicka; Neil P Shah; Anne Marie Velasco; Miles A Fabian; Daniel K Treiber; Zdravko V Milanov; Corey E Atteridge; William H Biggs; Philip T Edeen; Mark Floyd; Julia M Ford; Robert M Grotzfeld; Sanna Herrgard; Darren E Insko; Shamal A Mehta; Hitesh K Patel; William Pao; Charles L Sawyers; Harold Varmus; Patrick P Zarrinkar; David J Lockhart
Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(31):11011-6.
2005: Qiulu Pan; William Pao; Marc Ladanyi
Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas.
The Journal of molecular diagnostics : JMD 2005;7(3):396-403.
2005: William Pao; Vincent A Miller
Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(11):2556-68.
2005: William Pao; Vincent A Miller; Katerina Politi; Gregory J Riely; Romel Somwar; Maureen F Zakowski; Mark G Kris; Harold Varmus
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain.
PLoS medicine 2005;2(3):e73.
2005: Harold Varmus; William Pao; Katerina Politi; Katrina Podsypanina; Yi-Chieh Nancy Du
Oncogenes come of age.
Cold Spring Harbor symposia on quantitative biology 2005;70():1-9.
2005: William Pao; Theresa Y Wang; Gregory J Riely; Vincent A Miller; Qiulu Pan; Marc Ladanyi; Maureen F Zakowski; Robert T Heelan; Mark G Kris; Harold Varmus
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib.
PLoS medicine 2005;2(1):e17.
2005: Neelam T Shah; Mark G Kris; William Pao; Leslie Tyson; Barbara Pizzo; Murk-Hein Heinemann; Leah Ben-Porat; Dana L Sachs; Robert T Heelan; Vincent A Miller
Practical management of patients with non-small-cell lung cancer treated with gefitinib.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(1):165-74.
2004: William Pao; Vincent A Miller; Maureen F Zakowski; Jennifer Doherty; Katerina Politi; Inderpal S Sarkaria; Bhuvanesh Singh; Robert T Heelan; Valerie W Rusch; Lucinda Fulton; Elaine R Mardis; Doris Kupfer; Richard Wilson; Mark G Kris; Harold Varmus
EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(36):13306-11.
2004: William Pao; Vincent A Miller; Venkatraman E Seshan; Mark G Kris
Predicting sensitivity of non-small-cell lung cancer to gefitinib: is there a role for P-Akt?
Journal of the National Cancer Institute 2004;96(15):1117-9.
2004: Feijie Zhang; William Pao; Sarah M Umphress; Sonia B Jakowlew; Amy M Meyer; Lori D Dwyer-Nield; Katsuyuki Takeda; Erwin W Gelfand; J Fisher; Alvin M Malkinson; Robert J Mason
Serum levels of surfactant protein D are increased in mice with lung tumors.
Chest 2004;125(5 Suppl):109S.
2004: Vincent A Miller; Mark G Kris; Neelam Shah; Jyoti Patel; Christopher G Azzoli; Jorge Gomez; Lee M Krug; William Pao; Naiyer A Rizvi; Barbara Pizzo; Leslie Tyson; Venkatraman E Seshan; Leah Ben-Porat; Natalie Memoli; Maureen F Zakowski; Valerie W Rusch; Robert T Heelan
Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(6):1103-9.
2004: William Pao; Vincent A Miller; Mark G Kris
'Targeting' the epidermal growth factor receptor tyrosine kinase with gefitinib (Iressa) in non-small cell lung cancer (NSCLC).
Seminars in cancer biology 2004;14(1):33-40.
2003: Feng Cong; Jianxuan Zhang; William Pao; Pengbo Zhou; Harold Varmus
A protein knockdown strategy to study the function of beta-catenin in tumorigenesis.
BMC molecular biology 2003;4():10.
2003: Feijie Zhang; William Pao; Sarah M Umphress; Sonia B Jakowlew; Amy M Meyer; Lori D Dwyer-Nield; Larry D Nielsen; Katsuyuki Takeda; Erwin W Gelfand; James H Fisher; Lening Zhang; Alvin M Malkinson; Robert J Mason
Serum levels of surfactant protein D are increased in mice with lung tumors.
Cancer research 2003;63(18):5889-94.
2003: William Pao; David S Klimstra; Galen H Fisher; Harold Varmus
Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8764-9.