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Giuseppe Paradies

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Myocardial Reperfusion Injury

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Giuseppe Paradies; Valeria Paradies; Francesca M Ruggiero; Giuseppe Petrosillo
Changes in the mitochondrial permeability transition pore in aging and age-associated diseases.
Giuseppe Paradies; Giuseppe Petrosillo; Valeria Paradies; Francesca M Ruggiero
Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin.
Giuseppe Petrosillo; Nicola Di Venosa; N Moro; Giuseppe Colantuono; V Paradies; edy tiravanti; Antonio Federici; Francesca M Ruggiero; Giuseppe Paradies
In vivo hyperoxic preconditioning protects against rat-heart ischemia/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c release.

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All Publications

2013: Giuseppe Paradies; Valeria Paradies; Francesca M Ruggiero; Giuseppe Petrosillo
Changes in the mitochondrial permeability transition pore in aging and age-associated diseases.
Mechanisms of ageing and development 2013;134(1-2):1-9.
2011: Giuseppe Paradies; Giuseppe Petrosillo; Valeria Paradies; Francesca M Ruggiero
Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin.
Neurochemistry international 2011;58(4):447-57.
2011: Giuseppe Petrosillo; Nicola Di Venosa; N Moro; Giuseppe Colantuono; V Paradies; edy tiravanti; Antonio Federici; Francesca M Ruggiero; Giuseppe Paradies
In vivo hyperoxic preconditioning protects against rat-heart ischemia/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c release.
Free radical biology & medicine 2011;50(3):477-83.
2010: Consiglia Pacelli; Addolorata Coluccia; Ignazio Grattagliano; Tiziana Cocco; Giuseppe Petrosillo; Giuseppe Paradies; Emanuele De Nitto; Antonio Massaro; Michele Persichella; borracci pietro; Piero Portincasa; Maria Rosaria Carratù
Dietary choline deprivation impairs rat brain mitochondrial function and behavioral phenotype.
The Journal of nutrition 2010;140(6):1072-9.
2010: Giuseppe Paradies; Giuseppe Petrosillo; Valeria Paradies; Francesca M Ruggiero
Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging.
Free radical biology & medicine 2010;48(10):1286-95.
2010: Giuseppe Paradies; Giuseppe Petrosillo; Valeria Paradies; Russel J Reiter; Francesca M Ruggiero
Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease.
Journal of pineal research 2010;48(4):297-310.
2010: Giuseppe Petrosillo; Nicola Moro; Valeria Paradies; Francesca M Ruggiero; Giuseppe Paradies
Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin.
Journal of pineal research 2010;48(4):340-6.
2009: Giuseppe Petrosillo; Giuseppe Colantuono; Nicola Moro; Francesca M Ruggiero; edy tiravanti; Nicola Di Venosa; Tommaso Fiore; Giuseppe Paradies
Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening.
American journal of physiology. Heart and circulatory physiology 2009;297(4):H1487-93.
2009: Giuseppe Petrosillo; Nicola Moro; Francesca M Ruggiero; Giuseppe Paradies
Melatonin inhibits cardiolipin peroxidation in mitochondria and prevents the mitochondrial permeability transition and cytochrome c release.
Free radical biology & medicine 2009;47(7):969-74.
2009: Giuseppe Paradies; Giuseppe Petrosillo; Valeria Paradies; Francesca M Ruggiero
Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease.
Cell calcium 2009;45(6):643-50.
2008: Giuseppe Petrosillo; M Matera; Giacoma Casanova; Francesca M Ruggiero; Giuseppe Paradies
Mitochondrial dysfunction in rat brain with aging Involvement of complex I, reactive oxygen species and cardiolipin.
Neurochemistry international 2008;53(5):126-31.
2008: Giuseppe Petrosillo; Patrizia Fattoretti; Mariagiuseppa Matera; Francesca M Ruggiero; Carlo Bertoni-Freddari; Giuseppe Paradies
Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection.
Rejuvenation research 2008;11(5):935-43.
2007: Giuseppe Petrosillo; Giacoma Casanova; Mariagiuseppa Matera; Francesca M Ruggiero; Giuseppe Paradies
Synergistic effect of Ca2+ and peroxidized cardiolipin in the induction of permeability transition and cytochrome c release in rat heart mitochondria.
The Italian journal of biochemistry 2007;56(4):307-9.
2007: Giuseppe Petrosillo; Piero Portincasa; Ignazio Grattagliano; Giacoma Casanova; Mariagiuseppa Matera; Francesca M Ruggiero; Domenico Ferri; Giuseppe Paradies
Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipin.
Biochimica et biophysica acta 2007;1767(10):1260-7.
2006: Giuseppe Petrosillo; Giacoma Casanova; Mariagiuseppa Matera; Francesca M Ruggiero; Giuseppe Paradies
Interaction of peroxidized cardiolipin with rat-heart mitochondrial membranes: induction of permeability transition and cytochrome c release.
FEBS letters 2006;580(27):6311-6.
2006: Giuseppe Petrosillo; Nicola Di Venosa; Marilva Pistolese; Giacoma Casanova; edy tiravanti; Giuseppe Colantuono; Antonio Federici; Giuseppe Paradies; Francesca M Ruggiero
Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia- reperfusion: role of cardiolipin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(2):269-76.
2005: Giuseppe Petrosillo; Nicola Di Venosa; Francesca M Ruggiero; Marilva Pistolese; Donato D'Agostino; edy tiravanti; Tommaso Fiore; Giuseppe Paradies
Mitochondrial dysfunction associated with cardiac ischemia/reperfusion can be attenuated by oxygen tension control. Role of oxygen-free radicals and cardiolipin.
Biochimica et biophysica acta 2005;1710(2-3):78-86.
2004: Giuseppe Petrosillo; Francesca M Ruggiero; Marilva Pistolese; Giuseppe Paradies
Ca2+-induced reactive oxygen species production promotes cytochrome c release from rat liver mitochondria via mitochondrial permeability transition (MPT)-dependent and MPT-independent mechanisms: role of cardiolipin.
The Journal of biological chemistry 2004;279(51):53103-8.
2004: Giuseppe Paradies; Giuseppe Petrosillo; Marilva Pistolese; Nicola Di Venosa; Antonio Federici; Francesca M Ruggiero
Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin.
Circulation research 2004;94(1):53-9.
2003: Giuseppe Petrosillo; Francesca M Ruggiero; Giuseppe Paradies
Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(15):2202-8.
2003: Giuseppe Petrosillo; Francesca M Ruggiero; Nicola Di Venosa; Giuseppe Paradies
Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipin.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):714-6.
2002: Leonardo Montinaro; Giuseppe Paradies; Samuele Leggio
The Lortat-Jacob operation by laparoscopic access to treat gastroesophageal reflux in pediatric patients. Preliminary results.
Surgical endoscopy 2002;16(10):1438-40.
2002: Giuseppe Paradies; Giuseppe Petrosillo; Marilva Pistolese; Francesca M Ruggiero
Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage.
Gene 2002;286(1):135-41.
2001: Giuseppe Petrosillo; Francesca M Ruggiero; Marilva Pistolese; Giuseppe Paradies
Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis.
FEBS letters 2001;509(3):435-8.
2001: Giuseppe Paradies; Giuseppe Petrosillo; Marilva Pistolese; Francesca M Ruggiero
Reactive oxygen species generated by the mitochondrial respiratory chain affect the complex III activity via cardiolipin peroxidation in beef-heart submitochondrial particles.
Mitochondrion 2001;1(2):151-9.
2000: Giuseppe Grandaliano; Loreto Gesualdo; Fabio Bartoli; Elena Ranieri; Rosa Monno; Antonio Leggio; Giuseppe Paradies; E Caldarulo; Barbara Infante; Francesco Paolo Schena
MCP-1 and EGF renal expression and urine excretion in human congenital obstructive nephropathy.
Kidney international 2000;58(1):182-92.
2000: Fabio Bartoli; Loreto Gesualdo; Giuseppe Paradies; E Caldarulo; Barbara Infante; Giuseppe Grandaliano; Rosa Monno; Samuele Leggio; F Salzillo; Francesco Paolo Schena; Antonio Leggio
Renal expression of monocyte chemotactic protein-1 and epidermal growth factor in children with obstructive hydronephrosis.
Journal of pediatric surgery 2000;35(4):569-72.
2000: Giuseppe Paradies; Giuseppe Petrosillo; Marilva Pistolese; Francesca M Ruggiero
The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles.
FEBS letters 2000;466(2-3):323-6.
1999: Giuseppe Paradies; Giuseppe Petrosillo; Maria Nicola Gadaleta; Francesca M Ruggiero
The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria.
FEBS letters 1999;454(3):207-9.
1999: Giuseppe Paradies; Giuseppe Petrosillo; Marilva Pistolese; Nicola Di Venosa; D Serena; Francesca M Ruggiero
Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion.
Free radical biology & medicine 1999;27(1-2):42-50.
1998: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; E Quagliariello
Peroxidative damage to cardiac mitochondria: cytochrome oxidase and cardiolipin alterations.
FEBS letters 1998;424(3):155-8.
1997: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; E Quagliariello
Alterations in carnitine-acylcarnitine translocase activity and in phospholipid composition in heart mitochondria from hypothyroid rats.
Biochimica et biophysica acta 1997;1362(2-3):193-200.
1997: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; E Quagliariello
Age-dependent decline in the cytochrome c oxidase activity in rat heart mitochondria: role of cardiolipin.
FEBS letters 1997;406(1-2):136-8.
1997: Giuseppe Paradies; Giuseppe Petrosillo; Francesca M Ruggiero
Cardiolipin-dependent decrease of cytochrome c oxidase activity in heart mitochondria from hypothyroid rats.
Biochimica et biophysica acta 1997;1319(1):5-8.
1996: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; E Quagliariello
Stimulation of carnitine acylcarnitine translocase activity in heart mitochondria from hyperthyroid rats.
FEBS letters 1996;397(2-3):260-2.
1996: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; E Quagliariello
Age-dependent impairment of mitochondrial function in rat heart tissue. Effect of pharmacological agents.
Annals of the New York Academy of Sciences 1996;786():252-63.
1995: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; Maria Nicola Gadaleta; E Quagliariello
Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine.
Mechanisms of ageing and development 1995;84(2):103-12.
1994: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; Maria Nicola Gadaleta; E Quagliariello
Effect of aging and acetyl-L-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria.
FEBS letters 1994;350(2-3):213-5.
1994: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; Maria Nicola Gadaleta; E Quagliariello
The effect of aging and acetyl-L-carnitine on the function and on the lipid composition of rat heart mitochondria.
Annals of the New York Academy of Sciences 1994;717():233-43.
1994: Rosa Monno; MA Valenza; Michele Quarto; V Sabato; Domenico De Mattia; Giuseppe Paradies; L Montinaro; D Fumarola
Yersinia enterocolitica infection in a boy with beta thalassemia major.
The Pediatric infectious disease journal 1994;13(3):233-4.
1994: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; E Quagliariello
Enhanced cytochrome oxidase activity and modification of lipids in heart mitochondria from hyperthyroid rats.
Biochimica et biophysica acta 1994;1225(2):165-70.
1993: Giuseppe Paradies; Francesca M Ruggiero; P Dinoi; Giuseppe Petrosillo; E Quagliariello
Decreased cytochrome oxidase activity and changes in phospholipids in heart mitochondria from hypothyroid rats.
Archives of biochemistry and biophysics 1993;307(1):91-5.
1993: Giuseppe Paradies; Francesca M Ruggiero; Giuseppe Petrosillo; E Quagliariello
Age-dependent decrease in the cytochrome c oxidase activity and changes in phospholipids in rat-heart mitochondria.
Archives of gerontology and geriatrics 1993;16(3):263-72.
1992: Giuseppe Paradies; Francesca M Ruggiero; E Quagliariello
Age-dependent changes in the activity of anion carriers and in the lipid composition in rat heart mitochondria.
Annals of the New York Academy of Sciences 1992;673():160-4.
1992: Giuseppe Paradies; Francesca M Ruggiero; P Dinoi
Decreased activity of the phosphate carrier and modification of lipids in cardiac mitochondria from senescent rats.
The International journal of biochemistry 1992;24(5):783-7.
1992: Giuseppe Paradies; Francesca M Ruggiero; Maria Nicola Gadaleta; E Quagliariello
The effect of aging and acetyl-L-carnitine on the activity of the phosphate carrier and on the phospholipid composition in rat heart mitochondria.
Biochimica et biophysica acta 1992;1103(2):324-6.
1991: Giuseppe Paradies; Francesca M Ruggiero; P Dinoi
The influence of hypothyroidism on the transport of phosphate and on the lipid composition in rat-liver mitochondria.
Biochimica et biophysica acta 1991;1070(1):180-6.
1991: Giuseppe Paradies; Francesca M Ruggiero
Effect of aging on the activity of the phosphate carrier and on the lipid composition in rat liver mitochondria.
Archives of biochemistry and biophysics 1991;284(2):332-7.
1990: Giuseppe Paradies; Francesca M Ruggiero
Stimulation of phosphate transport in rat-liver mitochondria by thyroid hormones.
Biochimica et biophysica acta 1990;1019(2):133-6.
1990: Giuseppe Paradies; Francesca M Ruggiero
Enhanced activity of the tricarboxylate carrier and modification of lipids in hepatic mitochondria from hyperthyroid rats.
Archives of biochemistry and biophysics 1990;278(2):425-30.
1990: Giuseppe Paradies; Francesca M Ruggiero
Age-related changes in the activity of the pyruvate carrier and in the lipid composition in rat-heart mitochondria.
Biochimica et biophysica acta 1990;1016(2):207-12.
1989: Giuseppe Paradies; Francesca M Ruggiero
Decreased activity of the pyruvate translocator and changes in the lipid composition in heart mitochondria from hypothyroid rats.
Archives of biochemistry and biophysics 1989;269(2):595-602.
1988: Giuseppe Paradies; Francesca M Ruggiero
The effect of doxorubicin on the transport of pyruvate in rat-heart mitochondria.
Biochemical and biophysical research communications 1988;156(3):1302-7.
1988: Giuseppe Paradies; Francesca M Ruggiero
Effect of hyperthyroidism on the transport of pyruvate in rat-heart mitochondria.
Biochimica et biophysica acta 1988;935(1):79-86.
1988: Giuseppe Paradies
The effect of phenylglyoxal on the translocation of pyruvate in rat-heart mitochondria.
Biochimica et biophysica acta 1988;932(1):1-7.
1986: Giuseppe Paradies; Francesca M Ruggiero
Characterization of the alpha-cyanocinnamate binding site in rat heart mitochondria and in submitochondrial particles.
Biochimica et biophysica acta 1986;850(2):249-55.