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Christos Paraskeva

Research Profile

Disorders

Anatomy

Chemicals & Drugs

Physiology

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Mouse

Genes & Molecular Sequences

Genes, p53

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Publications

TOP 3
Manal R A Al-Kharusi; Tracey J Collard; Elizabeth D Emery; Alexander Greenhough; H J M Smartt; Ann C Williams; Christos Paraskeva
LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs.
H J M Smartt; Ann C Williams; M Al-Kharusi; Tracey J Collard; Alexander Greenhough; Joerg Huelsken; John M Mariadason; Paloma Ordóñez-Morán; Christos Paraskeva
β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
Anthony R Dallosso; M Frank; Alexander Greenhough; Anne L Hancock; C Owen; Christos Paraskeva; M Szemes; K Thorsen; B Øster; Claus L Andersen; T J Curry; Karim Malik
Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.

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All Publications

2013: Manal R A Al-Kharusi; Tracey J Collard; Elizabeth D Emery; Alexander Greenhough; H J M Smartt; Ann C Williams; Christos Paraskeva
LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs.
Carcinogenesis 2013;34(5):1150-7.
2012: H J M Smartt; Ann C Williams; M Al-Kharusi; Tracey J Collard; Alexander Greenhough; Joerg Huelsken; John M Mariadason; Paloma Ordóñez-Morán; Christos Paraskeva
β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?
British journal of cancer 2012;107(9):1514-7.
2012: Anthony R Dallosso; M Frank; Alexander Greenhough; Anne L Hancock; C Owen; Christos Paraskeva; M Szemes; K Thorsen; B Øster; Claus L Andersen; T J Curry; Karim Malik
Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways.
Oncogene 2012;31(40):4409-19.
2012: Helena J M Smartt; Elena Talero; Catherine A Wallam; Ann C Williams; Lee Parry; Heather R Roberts; Manal Al Kharusi; Catherine A Cherry; Alan R Clarke; Alexander Greenhough; Joerg Huelsken; John M Mariadason; Paloma Ordóñez-Morán; Christos Paraskeva
β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells.
Gut 2012;61(9):1306-14.
2012: S L Southern; Paul A Townsend; B C Urban; Tracey J Collard; Angela Hague; F Oakley; Christos Paraskeva; N D Perkins; V R Skeen; H J M Smartt; Ann C Williams
BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis.
Oncogene 2012;31(22):2761-72.
2012: Tracey J Collard; Angela Hague; Christos Paraskeva; Helena A Patsos; Paul A Townsend; B C Urban; Ann C Williams
The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells.
Cell death & disease 2012;3():e408.
2012: Victoria R Skeen; Christos Paraskeva; Ian Paterson; Ann C Williams
TGF-β1 signalling, connecting aberrant inflammation and colorectal tumorigenesis.
Current pharmaceutical design 2012;18(26):3874-88.
2011: Heather R Roberts; Helena J M Smartt; Ann C Williams; Alexander Greenhough; Amy E Moore; Christos Paraskeva
Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.
Carcinogenesis 2011;32(11):1741-7.
2010: Helena A Patsos; Alexander Greenhough; Diane J Hicks; Manal Al Kharusi; Tracey J Collard; Jon D Lane; Christos Paraskeva; Ann C Williams
The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.
International journal of oncology 2010;37(1):187-93.
2010: Alexander Greenhough; C A Wallam; Diane J Hicks; Moganaden Moorghen; Ann C Williams; Christos Paraskeva
The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE(2) signalling in colorectal adenoma cells.
Oncogene 2010;29(23):3398-410.
2009: David Qualtrough; K Singh; N Banu; Christos Paraskeva; Massimo Pignatelli
The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro.
British journal of cancer 2009;101(7):1124-9.
2009: Amy E Moore; Alexander Greenhough; Heather R Roberts; Diane J Hicks; Helena A Patsos; Ann C Williams; Christos Paraskeva
HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.
Carcinogenesis 2009;30(10):1796-804.
2009: Alexander Greenhough; Helena J M Smartt; Amy E Moore; Heather R Roberts; Ann C Williams; Christos Paraskeva; Abderrahmane Kaidi
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.
Carcinogenesis 2009;30(3):377-86.
2008: Alex Varey; E S Rennel; Y Qiu; H S Bevan; R M Perrin; S Raffy; A R Dixon; Christos Paraskeva; Oliver J Zaccheo; Andrew Bassim Hassan; Steven J Harper; David O Bates
VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy.
British journal of cancer 2008;98(8):1366-79.
2008: Nadine K Clemo; Tracey J Collard; Samantha L Southern; Kieron D Edwards; Moganaden Moorghen; Graham Packham; Angela Hague; Christos Paraskeva; Ann C Williams
BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity.
Carcinogenesis 2008;29(4):849-57.
2007: Alexander Greenhough; Helena A Patsos; Ann C Williams; Christos Paraskeva
The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.
International journal of cancer. Journal international du cancer 2007;121(10):2172-80.
2007: Abderrahmane Kaidi; Moganaden Moorghen; Ann C Williams; Christos Paraskeva
Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia?
Gut 2007;56(11):1637-8.
2007: N Banu; Andrea Buda; Simon Chell; D Elder; Moganaden Moorghen; Christos Paraskeva; David Qualtrough; Massimo Pignatelli
Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy.
Cell proliferation 2007;40(5):768-79.
2007: David Qualtrough; Abderrahmane Kaidi; Simon Chell; Henry N Jabbour; Ann C Williams; Christos Paraskeva
Prostaglandin F(2alpha) stimulates motility and invasion in colorectal tumor cells.
International journal of cancer. Journal international du cancer 2007;121(4):734-40.
2007: Abderrahmane Kaidi; Ann C Williams; Christos Paraskeva
Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia.
Nature cell biology 2007;9(2):210-7.
2007: Ann C Williams; H J M Smartt; Akram M H-Zadeh; Marion MacFarlane; Christos Paraskeva; Tracey J Collard
Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB.
Cell death and differentiation 2007;14(1):137-45.
2006: Akram M H-Zadeh; Tracey J Collard; Karim Malik; Diane J Hicks; Christos Paraskeva; Ann C Williams
Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells.
International journal of oncology 2006;29(5):1279-86.
2006: Simon Chell; Abderrahmane Kaidi; Abderrahmane Kadi; Ann C Williams; Christos Paraskeva
Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer.
Biochimica et biophysica acta 2006;1766(1):104-19.
2006: Abderrahmane Kaidi; David Qualtrough; Ann C Williams; Christos Paraskeva
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.
Cancer research 2006;66(13):6683-91.
2006: Simon Chell; Ian R Witherden; Richard R Dobson; Moganaden Moorghen; Andrew A Herman; David Qualtrough; Ann C Williams; Christos Paraskeva
Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence.
Cancer research 2006;66(6):3106-13.
2005: Helena A Patsos; Diane J Hicks; R R H Dobson; Alexander Greenhough; N Woodman; Jon D Lane; Ann C Williams; Christos Paraskeva
The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2.
Gut 2005;54(12):1741-50.
2005: Andrew Bassim Hassan; Christos Paraskeva
Colorectal cancer prognosis: is it all mutation, mutation, mutation?
Gut 2005;54(9):1209-11.
2005: Helena A Patsos; Diane J Hicks; Alexander Greenhough; Ann C Williams; Christos Paraskeva
Cannabinoids and cancer: potential for colorectal cancer therapy.
Biochemical Society transactions 2005;33(Pt 4):712-4.
2005: N K Clemo; Nathalie J Arhel; J D Barnes; J Baker; Moganaden Moorghen; Graham Packham; Christos Paraskeva; Ann C Williams
The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.
Biochemical Society transactions 2005;33(Pt 4):676-8.
2005: Simon Chell; Helena A Patsos; David Qualtrough; Akram M H-Zadeh; Diane J Hicks; Abderrahmane Kaidi; I R Witherden; Ann C Williams; Christos Paraskeva
Prospects in NSAID-derived chemoprevention of colorectal cancer.
Biochemical Society transactions 2005;33(Pt 4):667-71.
2005: J D Barnes; Nathalie J Arhel; S S Lee; Adam Sharp; M Al-Okail; Graham Packham; Angela Hague; Christos Paraskeva; Ann C Williams
Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells.
Apoptosis : an international journal on programmed cell death 2005;10(2):301-11.
2005: Angela Hague; Diane J Hicks; F Hasan; H J M Smartt; GM Cohen; Christos Paraskeva; Marion MacFarlane
Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis.
British journal of cancer 2005;92(4):736-42.
2004: Angela Hague; Christos Paraskeva
Apoptosis and disease: a matter of cell fate.
Cell death and differentiation 2004;11(12):1366-72.
2004: David Qualtrough; Andrea Buda; William Gaffield; Ann C Williams; Christos Paraskeva
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment.
International journal of cancer. Journal international du cancer 2004;110(6):831-7.
2003: H J M Smartt; Douglas J E Elder; Diane J Hicks; N A Williams; Christos Paraskeva
Increased NF-kappaB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells.
British journal of cancer 2003;89(7):1358-65.
2003: Nathalie J Arhel; Graham Packham; Paul A Townsend; Tracey J Collard; Akram M H-Zadeh; Adam Sharp; Ramsey I Cutress; Karim Malik; Angela Hague; Christos Paraskeva; Ann C Williams
The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines.
International journal of cancer. Journal international du cancer 2003;106(3):364-71.
2003: Andrea Buda; David Qualtrough; Mark A Jepson; Diego Martines; Christos Paraskeva; Massimo Pignatelli
Butyrate downregulates alpha2beta1 integrin: a possible role in the induction of apoptosis in colorectal cancer cell lines.
Gut 2003;52(5):729-34.
2003: Tracey J Collard; M Guy; A J Butt; Claire M Perks; Jeff M P Holly; Christos Paraskeva; Ann C Williams
Transcriptional upregulation of the insulin-like growth factor binding protein IGFBP-3 by sodium butyrate increases IGF-independent apoptosis in human colonic adenoma-derived epithelial cells.
Carcinogenesis 2003;24(3):393-401.
2002: Douglas J E Elder; Jenny A Baker; Nahida A Banu; Moganaden Moorghen; Christos Paraskeva
Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression.
The Journal of pathology 2002;198(4):428-34.
2002: David Qualtrough; T Hinoi; Eric R Fearon; Christos Paraskeva
Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system.
Gut 2002;51(2):184-90.
2002: L C Playle; Diane J Hicks; David Qualtrough; Christos Paraskeva
Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines.
British journal of cancer 2002;87(3):352-8.
2002: Douglas J E Elder; Dawn E Halton; Laura C Playle; Christos Paraskeva
The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells.
International journal of cancer. Journal international du cancer 2002;99(3):323-7.
2001: M Guy; Moganaden Moorghen; J A Bond; Tracey J Collard; Christos Paraskeva; Ann C Williams
Transcriptional down-regulation of the retinoblastoma protein is associated with differentiation and apoptosis in human colorectal epithelial cells.
British journal of cancer 2001;84(4):520-8.
2000: Douglas J E Elder; Dawn E Halton; T E Crew; Christos Paraskeva
Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug NS-398.
International journal of cancer. Journal international du cancer 2000;86(4):553-60.
2000: G D Díaz; Christos Paraskeva; M G Thomas; L Binderup; Angela Hague
Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy.
Cancer research 2000;60(8):2304-12.
2000: Ann C Williams; Tracey J Collard; Claire M Perks; Paul Newcomb; Moganaden Moorghen; Jeff M P Holly; Christos Paraskeva
Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells.
Cancer research 2000;60(1):22-7.
2000: T E Crew; Douglas J E Elder; Christos Paraskeva
A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate.
Carcinogenesis 2000;21(1):69-77.
1999: Douglas J E Elder; Christos Paraskeva
Induced apoptosis in the prevention of colorectal cancer by non-steroidal anti-inflammatory drugs.
Apoptosis : an international journal on programmed cell death 1999;4(5):365-72.
1999: Ann C Williams; Tracey J Collard; Christos Paraskeva
An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis.
Oncogene 1999;18(21):3199-204.
1998: Angela Hague; TS Bracey; Diane J Hicks; J C Reed; Christos Paraskeva
Decreased levels of p26-Bcl-2, but not p30 phosphorylated Bcl-2, precede TGFbeta1-induced apoptosis in colorectal adenoma cells.
Carcinogenesis 1998;19(9):1691-5.
1998: B Singh; Christos Paraskeva
Bcl-2 as a possible sensor of nutritional stress inhibiting apoptosis and allowing cell survival during colorectal carcinogenesis.
Biochemical Society transactions 1998;26(2):236-41.
1998: S J Browne; Marion MacFarlane; GM Cohen; Christos Paraskeva
The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases.
Cell death and differentiation 1998;5(3):206-13.
1997: A J Butt; Angela Hague; Christos Paraskeva
Butyrate- but not TGFbeta1-induced apoptosis of colorectal adenoma cells is associated with increased expression of the differentiation markers E-cadherin and alkaline phosphatase.
Cell death and differentiation 1997;4(8):725-32.
1997: Douglas J E Elder; Christos Paraskeva
NSAIDs to prevent colorectal cancer: a question of sensitivity.
Gastroenterology 1997;113(6):1999-2003.
1997: D G Palmer; Christos Paraskeva; Ann C Williams
Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate.
International journal of cancer. Journal international du cancer 1997;73(5):702-6.
1997: Douglas J E Elder; Dawn E Halton; Angela Hague; Christos Paraskeva
Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(10):1679-83.
1997: Angela Hague; G D Diaz; Diane J Hicks; S Krajewski; J C Reed; Christos Paraskeva
bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis.
International journal of cancer. Journal international du cancer 1997;72(5):898-905.
1997: Ann C Williams; J C Miller; Tracey J Collard; S J Browne; R F Newbold; Christos Paraskeva
The effect of different TP53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with endogenous wild type TP53 activity, before and after DNA damage.
Genes, chromosomes & cancer 1997;20(1):44-52.
1997: TS Bracey; A C Williams; Christos Paraskeva
Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(8):1371-81.
1997: B Singh; Andrew P Halestrap; Christos Paraskeva
Butyrate can act as a stimulator of growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources.
Carcinogenesis 1997;18(6):1265-70.
1997: Angela Hague; B Singh; Christos Paraskeva
Butyrate acts as a survival factor for colonic epithelial cells: further fuel for the in vivo versus in vitro debate.
Gastroenterology 1997;112(3):1036-40.
1997: Angela Hague; Diane J Hicks; TS Bracey; Christos Paraskeva
Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: growth factors protect against c-myc-independent apoptosis.
British journal of cancer 1997;75(7):960-8.
1996: Angela Hague; A J Butt; Christos Paraskeva
The role of butyrate in human colonic epithelial cells: an energy source or inducer of differentiation and apoptosis?
The Proceedings of the Nutrition Society 1996;55(3):937-43.
1996: Ann C Williams; Angela Hague; Douglas J E Elder; Christos Paraskeva
In vitro models for studying colorectal carcinogenesis: cellular and molecular events including APC and Rb cleavage in the control of proliferation, differentiation and apoptosis.
Biochimica et biophysica acta 1996;1288(1):F9-19.
1996: J W van der Stappen; Ann C Williams; R A Maciewicz; Christos Paraskeva
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D.
International journal of cancer. Journal international du cancer 1996;67(4):547-54.
1996: Douglas J E Elder; Angela Hague; Diane J Hicks; Christos Paraskeva
Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.
Cancer research 1996;56(10):2273-6.
1995: Angela Hague; Christos Paraskeva
The short-chain fatty acid butyrate induces apoptosis in colorectal tumour cell lines.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 1995;4(5):359-64.
1995: Ann C Williams; J C Miller; T J Collard; T S Bracey; S Cosulich; Christos Paraskeva
Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation.
Oncogene 1995;11(1):141-9.
1995: T S Bracey; J C Miller; Alan Preece; Christos Paraskeva
Gamma-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53.
Oncogene 1995;10(12):2391-6.
1995: Angela Hague; Douglas J E Elder; Diane J Hicks; Christos Paraskeva
Apoptosis in colorectal tumour cells: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate.
International journal of cancer. Journal international du cancer 1995;60(3):400-6.
1994: Angela Hague; M Moorghen; D Hicks; M Chapman; Christos Paraskeva
BCL-2 expression in human colorectal adenomas and carcinomas.
Oncogene 1994;9(11):3367-70.
1994: W B Mackinnon; L Huschtscha; K Dent; R Hancock; Christos Paraskeva; Carolyn E Mountford
Correlation of cellular differentiation in human colorectal carcinoma and adenoma cell lines with metabolite profiles determined by 1H magnetic resonance spectroscopy.
International journal of cancer. Journal international du cancer 1994;59(2):248-61.
1994: S J Browne; Ann C Williams; Angela Hague; A J Butt; Christos Paraskeva
Loss of APC protein expressed by human colonic epithelial cells and the appearance of a specific low-molecular-weight form is associated with apoptosis in vitro.
International journal of cancer. Journal international du cancer 1994;59(1):56-64.
1994: Ann C Williams; S J Browne; A M Manning; P Daffada; T J Collard; Christos Paraskeva
Transfection and expression of mutant p53 protein does not alter the in vivo or in vitro growth characteristics of the AA/C1 human adenoma derived cell line, including sensitivity to transforming growth factor-beta 1.
Oncogene 1994;9(5):1479-85.
1993: Ann C Williams; S J Browne; W A Yeudal; Ian C Paterson; C J Marshall; D P Lane; Christos Paraskeva
Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.
Oncogene 1993;8(11):3063-72.
1993: Angela Hague; A M Manning; K A Hanlon; L I Huschtscha; D Hart; Christos Paraskeva
Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large-bowel cancer.
International journal of cancer. Journal international du cancer 1993;55(3):498-505.
1993: Angela Hague; A M Manning; J W van der Stappen; Christos Paraskeva
Escape from negative regulation of growth by transforming growth factor beta and from the induction of apoptosis by the dietary agent sodium butyrate may be important in colorectal carcinogenesis.
Cancer metastasis reviews 1993;12(3-4):227-37.
1993: A Avery; Christos Paraskeva; P Hall; K C Flanders; Michael B. Sporn; M Moorghen
TGF-beta expression in the human colon: differential immunostaining along crypt epithelium.
British journal of cancer 1993;68(1):137-9.
1993: Ann C Williams; S J Browne; A M Manning; Angela Hague; J W van der Stappen; Christos Paraskeva
Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.
Seminars in cancer biology 1993;4(3):153-9.
1993: Ann C Williams; Angela Hague; A M Manning; J W Van der Stappen; Christos Paraskeva
In vitro models of human colorectal cancer.
Cancer surveys 1993;16():15-29.
1992: Ann C Williams; S J Harper; C J Marshall; R W Gill; R A Mountford; Christos Paraskeva
Specific cytogenetic abnormalities and k-ras mutation in two new human colorectal-adenoma-derived cell lines.
International journal of cancer. Journal international du cancer 1992;52(5):785-90.
1992: Christos Paraskeva; Ann C Williams
Cell and molecular biology of gastrointestinal tract cancer.
Current opinion in oncology 1992;4(4):707-13.
1992: Christos Paraskeva; Angela Hague; N Rooney; Ann C Williams; S J Harper; K A Hanlon; R J Atkinson; Anthony P Corfield
A single human colonic adenoma cell line can be converted in vitro to both a colorectal adenocarcinoma and a mucinous carcinoma.
International journal of cancer. Journal international du cancer 1992;51(4):661-4.
1991: J W van der Stappen; Christos Paraskeva; Ann C Williams; Angela Hague; R A Maciewicz
Relationship between the secretion of cysteine proteinases and their inhibitors and malignant potential.
Biochemical Society transactions 1991;19(4):362S.
1991: A M Manning; Ann C Williams; S M Game; Christos Paraskeva
Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.
Oncogene 1991;6(8):1471-6.
1990: Christos Paraskeva; Anthony P Corfield; S Harper; Angela Hague; K Audcent; Ann C Williams
Colorectal carcinogenesis: sequential steps in the in vitro immortalization and transformation of human colonic epithelial cells (review).
Anticancer research 1990;10(5A):1189-200.
1990: Ann C Williams; S J Harper; Christos Paraskeva
Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence.
Cancer research 1990;50(15):4724-30.
1990: Christos Paraskeva; Ann C Williams
Are different events involved in the development of sporadic versus hereditary tumours? The possible importance of the microenvironment in hereditary cancer.
British journal of cancer 1990;61(6):828-30.
1989: Christos Paraskeva; A Harvey; S Finerty; S Powell
Possible involvement of chromosome 1 in in vitro immortalization: evidence from progression of a human adenoma-derived cell line in vitro.
International journal of cancer. Journal international du cancer 1989;43(4):743-6.
1989: R A Maciewicz; R J Wardale; D J Etherington; Christos Paraskeva
Immunodetection of cathepsins B and L present in and secreted from human pre-malignant and malignant colorectal tumour cell lines.
International journal of cancer. Journal international du cancer 1989;43(3):478-86.
1989: Christos Paraskeva; S Finerty; R A Mountford; S C Powell
Specific cytogenetic abnormalities in two new human colorectal adenoma-derived epithelial cell lines.
Cancer research 1989;49(5):1282-6.
1988: Christine J Farr; C J Marshall; David J Easty; N A Wright; S C Powell; Christos Paraskeva
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
Oncogene 1988;3(6):673-8.
1988: Christos Paraskeva; S Finerty; S Powell
Immortalization of a human colorectal adenoma cell line by continuous in vitro passage: possible involvement of chromosome 1 in tumour progression.
International journal of cancer. Journal international du cancer 1988;41(6):908-12.
1988: R D Berry; Christos Paraskeva
Expression of carcinoembryonic antigen by adenoma and carcinoma derived epithelial cell lines: possible marker of tumour progression and modulation of expression by sodium butyrate.
Carcinogenesis 1988;9(3):447-50.
1988: R D Berry; S C Powell; Christos Paraskeva
In vitro culture of human foetal colonic epithelial cells and their transformation with origin minus SV40 DNA.
British journal of cancer 1988;57(3):287-9.