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Drew Pardoll

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Jing Zeng; Emilia Albesiano; Zineb Belcaid; Henry Brem; Charles G Drake; Nicholas Durham; Eric Ford; Hans-Joerg Hammers; Timothy J Harris; Christopher M Jackson; Dimitris Mathios; Christian Meyer; Drew M Pardoll; Jillian Phallen; Gustavo Pradilla; Jacob Ruzevick; Alfred P See; Phuoc Tran; Betty Tyler; John Wong; Michael Lim
Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas.
David Vasquez-Dunddel; Qi Zeng; Hao Zhang; Fan Pan; Drew M Pardoll; Ada J Tam; Emilia Albesiano; Richard L Blosser; Tullia Bruno; Juan Fu; Mikhail Gorbounov; Young Kim
STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients.
Sofia Lyford-Pike; Belinda Akpeng; Justin A Bishop; Tullia C Bruno; Lieping Chen; Charles G Drake; Drew M Pardoll; Shiwen Peng; Jeremy D Richmon; Janis M Taube; Suzanne Topalian; Hao Wang; William H Westra; Geoffrey D Young; Sara I Pai
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma.

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All Publications

2013: Jing Zeng; Emilia Albesiano; Zineb Belcaid; Henry Brem; Charles G Drake; Nicholas Durham; Eric Ford; Hans-Joerg Hammers; Timothy J Harris; Christopher M Jackson; Dimitris Mathios; Christian Meyer; Drew M Pardoll; Jillian Phallen; Gustavo Pradilla; Jacob Ruzevick; Alfred P See; Phuoc Tran; Betty Tyler; John Wong; Michael Lim
Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas.
International journal of radiation oncology, biology, physics 2013;86(2):343-9.
2013: David Vasquez-Dunddel; Qi Zeng; Hao Zhang; Fan Pan; Drew M Pardoll; Ada J Tam; Emilia Albesiano; Richard L Blosser; Tullia Bruno; Juan Fu; Mikhail Gorbounov; Young Kim
STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients.
The Journal of clinical investigation 2013;123(4):1580-9.
2013: Sofia Lyford-Pike; Belinda Akpeng; Justin A Bishop; Tullia C Bruno; Lieping Chen; Charles G Drake; Drew M Pardoll; Shiwen Peng; Jeremy D Richmon; Janis M Taube; Suzanne Topalian; Hao Wang; William H Westra; Geoffrey D Young; Sara I Pai
Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma.
Cancer research 2013;73(6):1733-41.
2013: Joseph Barbi; Drew M Pardoll; Fan Pan
Metabolic control of the Treg/Th17 axis.
Immunological reviews 2013;252(1):52-77.
2013: Evan J Lipson; Drew M Pardoll; Alice Pons; WILLIAM SHARFMAN; Janis M Taube; Robert A Anders; Julie R Brahmer; Lieping Chen; Charles G Drake; Ira Wollner; Haiying Xu; Sheng Yao; Suzanne Topalian
Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(2):462-8.
2012: Drew M Pardoll
Immunology beats cancer: a blueprint for successful translation.
Nature immunology 2012;13(12):1129-32.
2012: Alfred P See; Jing Zeng; Sarah Nicholas; Fan Pan; Drew M Pardoll; Jillian Phallen; Jacob Ruzevick; Emilia Albesiano; Zineb Belcaid; Zev Binder; Gary L Gallia; Chelsea Gottschalk; James E Han; Christopher Jackson; Sung Jin Jeong; Dilini Jinasena; Young Kim; Michael Lim
The role of STAT3 activation in modulating the immune microenvironment of GBM.
Journal of neuro-oncology 2012;110(3):359-68.
2012: Elizabeth C Wick; Christine A Iacobuzio-Donahue; Robert E LeBlanc; Guillermo Ortega; Drew M Pardoll; Elizabeth A Platz; Chelsea Robinson; Cynthia L Sears
Shift from pStat6 to pStat3 predominance is associated with inflammatory bowel disease-associated dysplasia.
Inflammatory bowel diseases 2012;18(7):1267-74.
2012: Kelly Olino; Xiaoyu Pan; Drew M Pardoll; Richard D Schulick; Jill Slansky; Koji Tamada; Satoshi Wada; Walter Weber; Dirk Brockstedt; BARISH EDIL; Peter Lauer; Kristen Meckel; Kiyoshi Yoshimura
Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases.
Annals of surgical oncology 2012;19 Suppl 3():S597-607.
2012: Julie R Brahmer; Luis H Camacho; Shuming Chen; Laura Q M Chow; Charles G Drake; Keith Eaton; Stacie M Goldberg; Joseph F Grosso; Ashok Gupta; Omid Hamid; Patrick Hwu; Wen-Jen Hwu; John Kauh; Alan J Korman; Renato Martins; Kunle Odunsi; Drew M Pardoll; Susan M Parker; Henry C Pitot; Theresa M Salay; Suzanne Topalian; Scott S Tykodi; Shruti Agrawal; Suresh Alaparthy; Shailender Bhatia; JON WIGGINTON
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer.
The New England journal of medicine 2012;366(26):2455-65.
2012: Suzanne Topalian; JON WIGGINTON; Haiying Xu; Janis M Taube; Shruti Agrawal; Robert A Anders; Scott J Antonia; Michael B Atkins; Julie R Brahmer; Richard D Carvajal; Lieping Chen; Charles G Drake; Scott N Gettinger; Ashok Gupta; F Stephen Hodi; Leora Horn; Maria Jure-Kunkel; Georgia D Kollia; Alan J Korman; Philip D Leming; David F McDermott; Daniel McDonald; Tracee L McMiller; Drew M Pardoll; John D Powderly; WILLIAM SHARFMAN; David C Smith; Jeffrey A Sosman; David R Spigel; Mario Sznol
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
The New England journal of medicine 2012;366(26):2443-54.
2012: Matthew L Bettini; David Finkelstein; Stefan Floess; Jochen Huehn; Fan Pan; Drew M Pardoll; Jerold E Rehg; Bryan D Bell; Maria Bettini; Steven F Ziegler; Dario A A Vignali
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.
Immunity 2012;36(5):717-30.
2012: Kelly Olino; Xiaoyu Pan; Drew M Pardoll; Richard D Schulick; Avesh Thuluvath; BARISH EDIL; Kristen F Meckel; Kiyoshi Yoshimura; Walter P Weber
Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated Listeria monocytogenes.
Archives of surgery (Chicago, Ill. : 1960) 2012;147(5):480-2.
2012: Drew M Pardoll
The blockade of immune checkpoints in cancer immunotherapy.
Nature reviews. Cancer 2012;12(4):252-64.
2012: Suzanne Topalian; Charles G Drake; Drew M Pardoll
Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity.
Current opinion in immunology 2012;24(2):207-12.
2012: Tullia C Bruno; Nicholas M Durham; Derese Getnet; Joseph Grosso; George Netto; Drew M Pardoll; Cristin Rothwell; Hung-Rong Yen; Charles G Drake
Anti-tumor effects of endogenous prostate cancer-specific CD8 T cells in a murine TCR transgenic model.
The Prostate 2012;72(5):514-22.
2012: Janis M Taube; Suzanne Topalian; Haiying Xu; Geoffrey D Young; Shuming Chen; Alison P Klein; Tracee L McMiller; Drew M Pardoll; Rajni Sharma; Robert A Anders; Lieping Chen
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape.
Science translational medicine 2012;4(127):127ra37.
2012: Seng-Ryong Woo; Creg J Workman; Peter Vogel; Jaishree Bankoti; Maria Bettini; Alcides Chaux; Charles G Drake; Monica V Goldberg; David M Gravano; Joseph Grosso; Alan J Korman; Chih Long Liu; George Netto; Christopher J Nirschl; Drew M Pardoll; Mark Selby; Matthew P Smeltzer; Stephanie Tangsombatvisit; Meghan E Turnis; Paul J Utz; Dario A A Vignali
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Cancer research 2012;72(4):917-27.
2012: Drew M Pardoll; Charles G Drake
Immunotherapy earns its spot in the ranks of cancer therapy.
The Journal of experimental medicine 2012;209(2):201-9.
2012: Kei Tomihara; Bin Zhang; Vincent J Hurez; Takako Shin; Drew M Pardoll; Hideo Yagita; Tyler J Curiel; Tahiro Shin
Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction.
Aging cell 2012;11(1):128-38.
2011: Suzanne Topalian; George J Weiner; Drew M Pardoll
Cancer immunotherapy comes of age.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(36):4828-36.
2011: Eric V Dang; Juan Fu; Dilini Jinasena; Young Kim; Weibo Luo; Joseph Barbi; Zachary Bordman; Chi Dang; Drew M Pardoll; Gregg L Semenza; Larissa A Shimoda; Suzanne Topalian; Huang-Yu Yang; Hung-Rong Yen; Hong Yu; Karen I Zeller; Ying Zheng; Fan Pan
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Cell 2011;146(5):772-84.
2011: Rachel W Humphrey; Kathleen M Dohoney; James H Doroshow; Sandra J Meech; Mark J Ratain; Suzanne Topalian; David T Bonk; Laura M Brockway-Lunardi; Drew M Pardoll
Opportunities and challenges in the development of experimental drug combinations for cancer.
Journal of the National Cancer Institute 2011;103(16):1222-6.
2011: Meghan B Davis; Juan Fu; Drew M Pardoll; David Vasquez-Dunddel; Emilia Albesiano; Young J Kim
Intratumoral administration of TLR4 agonist absorbed into a cellular vector improves antitumor responses.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(12):3984-92.
2011: Heehyoung Lee; Jiehui Deng; Hong Xin; Yong Liu; Drew M Pardoll; Hua Yu
A requirement of STAT3 DNA binding precludes Th-1 immunostimulatory gene expression by NF-κB in tumors.
Cancer research 2011;71(11):3772-80.
2011: Drew M Pardoll
Timeline: a decade of advances in immunotherapy.
Nature medicine 2011;17(3):296.
2011: Cynthia L Sears; Drew M Pardoll
Perspective: alpha-bugs, their microbial partners, and the link to colon cancer.
The Journal of infectious diseases 2011;203(3):306-11.
2010: Lin Wang; Tangsheng Yi; Wang Zhang; Drew M Pardoll; Hua Yu
IL-17 enhances tumor development in carcinogen-induced skin cancer.
Cancer research 2010;70(24):10112-20.
2010: Kimberly Noonan; LUIGI MARCHIONNI; Judy Anderson; Drew M Pardoll; G David Roodman; Ivan Borrello
A novel role of IL-17-producing lymphocytes in mediating lytic bone disease in multiple myeloma.
Blood 2010;116(18):3554-63.
2010: Emilia Albesiano; Meghan Davis; Alfred P See; James E Han; Michael Lim; Drew M Pardoll; Young Kim
Immunologic consequences of signal transducers and activators of transcription 3 activation in human squamous cell carcinoma.
Cancer research 2010;70(16):6467-76.
2010: DUNG LE; Drew M Pardoll; Elizabeth M Jaffee
Cellular vaccine approaches.
Cancer journal (Sudbury, Mass.) 2010;16(4):304-10.
2010: Julie R Brahmer; Charles G Drake; Ira Wollner; John D Powderly; Joel Picus; WILLIAM SHARFMAN; Elizabeth Stankevich; Alice Pons; Theresa M Salay; Tracee L McMiller; MARTA GILSON; Changyu Wang; Mark Selby; Janis M Taube; Robert A Anders; Lieping Chen; Alan J Korman; Drew M Pardoll; Israel Lowy; Suzanne Topalian
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(19):3167-75.
2010: Derese Getnet; Joseph F Grosso; Monica V Goldberg; Timothy J Harris; Hung-Rong Yen; Tullia C Bruno; Nicholas M Durham; Edward L Hipkiss; Kristin J Pyle; Satoshi Wada; Fan Pan; Drew M Pardoll; Charles G Drake
A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells.
Molecular immunology 2010;47(7-8):1595-600.
2010: Kenji Ishiwata; Naohiro Watanabe; Miao Guo; Kei Tomihara; Michael J Brumlik; Hideo Yagita; Drew M Pardoll; Lieping Chen; Tae Kwang Shin
Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):2086-94.
2009: Hung-Rong Yen; Timothy J Harris; Satoshi Wada; Joseph F Grosso; Derese Getnet; Monica V Goldberg; Kai-Li Liang; Tullia C Bruno; Kristin J Pyle; Siaw-Li Chan; Robert A Anders; Cornelia L Trimble; Adam J Adler; Tzou-Yien Lin; Drew M Pardoll; Ching-Tai Huang; Charles G Drake
Tc17 CD8 T cells: functional plasticity and subset diversity.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7161-8.
2009: Hua Yu; Drew M Pardoll; Richard Jove
STATs in cancer inflammation and immunity: a leading role for STAT3.
Nature reviews. Cancer 2009;9(11):798-809.
2009: Marcin Kortylewski; Piotr Swiderski; Andreas Herrmann; Lin Wang; Claudia Kowolik; Maciej Kujawski; Heehyoung Lee; Anna Scuto; Yong Liu; Chunmei Yang; Jiehui Deng; Harris S Soifer; Andrew Raubitschek; Stephen Forman; John J Rossi; Drew M Pardoll; Richard Jove; Hua Yu
In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses.
Nature biotechnology 2009;27(10):925-32.
2009: Kiyoshi Yoshimura; Kristen F Meckel; Lindsay S Laird; Christina Y Chia; Jang-June Park; Kelly L Olino; Ryouichi Tsunedomi; Toshio Harada; Norio Iizuka; Shoichi Hazama; Yukihiko Kato; Jesse W Keller; John M Thompson; Fumin Chang; Lewis H Romer; Ajay Jain; Christine A Iacobuzio-Donahue; Masaaki Oka; Drew M Pardoll; Richard D Schulick
Integrin alpha2 mediates selective metastasis to the liver.
Cancer research 2009;69(18):7320-8.
2009: Shaoguang Wu; Ki-Jong Rhee; Emilia Albesiano; Shervin Rabizadeh; Xinqun Wu; Hung-Rong Yen; David L Huso; frederick brancati; Elizabeth C Wick; Florencia McAllister; Franck Housseau; Drew M Pardoll; Cynthia L Sears
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
Nature medicine 2009;15(9):1016-22.
2009: Fan Pan; Hong Yu; Eric V Dang; Joseph Barbi; Xiaoyu Pan; Joseph F Grosso; Dinili Jinasena; Sudarshana M Sharma; Erin M McCadden; Derese Getnet; Charles G Drake; Jun O Liu; Michael C Ostrowski; Drew M Pardoll
Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells.
Science (New York, N.Y.) 2009;325(5944):1142-6.
2009: Maria Pletneva; Hongni Fan; Jang-June Park; Vedran Radojcic; Chunfa Jie; YANXING YU; Camie W Y Chan; Alec Redwood; Drew M Pardoll; Franck Housseau
IFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacity.
Cancer research 2009;69(16):6607-14.
2009: Drew M Pardoll
Metastasis-promoting immunity: when T cells turn to the dark side.
Cancer cell 2009;16(2):81-2.
2009: Lin Wang; Tangsheng Yi; Marcin Kortylewski; Drew M Pardoll; Defu Zeng; Hua Yu
IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway.
The Journal of experimental medicine 2009;206(7):1457-64.
2009: Joseph F Grosso; Monica V Goldberg; Derese Getnet; Tullia C Bruno; Hung-Rong Yen; Kristin J Pyle; Edward Hipkiss; Dario A A Vignali; Drew M Pardoll; Charles G Drake
Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6659-69.
2009: Satoshi Wada; Kiyoshi Yoshimura; Edward L Hipkiss; Tim J Harris; Hung-Rong Yen; Monica V Goldberg; Joseph F Grosso; Derese Getnet; Angelo M DeMarzo; GEORGES NETTO; Robert A Anders; Drew M Pardoll; Charles G Drake
Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model.
Cancer research 2009;69(10):4309-18.
2009: Derese Getnet; Charles H Maris; Edward L Hipkiss; Joseph Grosso; Timothy J Harris; Hung-Rong Yen; Tullia C Bruno; Satoshi Wada; Adam Adler; Robert W Georgantas; Chunfa Jie; Monica V Goldberg; Drew M Pardoll; Charles G Drake
Tumor recognition and self-recognition induce distinct transcriptional profiles in antigen-specific CD4 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):4675-85.
2009: Heehyoung Lee; Andreas Herrmann; Jie-Hui Deng; Maciej Kujawski; Guilian Niu; Zhiwei Li; Steve Forman; Richard Jove; Drew M Pardoll; Hua Yu
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.
Cancer cell 2009;15(4):283-93.
2009: Tianhong Wang; Qiong Jiang; Camie W Y Chan; Kevin Gorski; Erin McCadden; David Kardian; Drew M Pardoll; Katharine A Whartenby
Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR.
Blood 2009;113(13):2906-13.
2009: Creg J Workman; Yao Wang; Karim C El Kasmi; Drew M Pardoll; Peter J Murray; Charles G Drake; Dario A A Vignali
LAG-3 regulates plasmacytoid dendritic cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(4):1885-91.
2009: Marcin Kortylewski; Hong Xin; Maciej Kujawski; Heehyoung Lee; Yong Liu; Timothy Harris; Charles G Drake; Drew M Pardoll; Hua Yu
Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment.
Cancer cell 2009;15(2):114-23.
2009: Cornelia L Trimble; Shiwen Peng; FERDYNAND KOS; Patti Gravitt; Raphael P Viscidi; Elizabeth Sugar; Drew M Pardoll; Tzyy-choou Wu
A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(1):361-7.
2008: Alleluiah Rutebemberwa; Stuart C Ray; Jacquie Astemborski; Jordana Levine; Lin Liu; Kimberly A Dowd; Shalyn Clute; Changyu Wang; Alan Korman; Alessandro Sette; John Sidney; Drew M Pardoll; Andrea L Cox
High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(12):8215-25.
2008: Matthias Wölfl; Alleluiah Rutebemberwa; Timothy Mosbruger; Qing Mao; Hong-mei Li; Dale Netski; Stuart C Ray; Drew M Pardoll; John Sidney; Alessandro Sette; Todd Allen; Thomas Kuntzen; Daniel G Kavanagh; Jürgen Kuball; Philip D Greenberg; Andrea L Cox
Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(9):6435-46.
2008: Timothy J Harris; Edward L Hipkiss; Scott Borzillary; Satoshi Wada; Joseph Grosso; Hung-Rong Yen; Derese Getnet; Tullia C Bruno; Monica V Goldberg; Drew M Pardoll; Theodore L DeWeese; Charles G Drake
Radiotherapy augments the immune response to prostate cancer in a time-dependent manner.
The Prostate 2008;68(12):1319-29.
2008: Eleanor Barnes; M Salio; Vincenzo Cerundolo; L Francesco; Drew M Pardoll; Paul Klenerman; Andrea L Cox
Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus.
Journal of viral hepatitis 2008;15(3):219-28.
2008: Koichiro Matsumoto; Satoru Fukuyama; Miyuki Eguchi-Tsuda; Takako Nakano; Takafumi Matsumoto; Mikiko Matsumura; Atsushi Moriwaki; Keiko Kan-o; Yoshihiro Wada; Hideo Yagita; Tae Kwang Shin; Drew M Pardoll; Rirprajak Patcharee; Miyuki Azuma; Yoichi Nakanishi; Hiromasa Inoue
B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma.
Biochemical and biophysical research communications 2008;365(1):170-5.
2008: Kimberly R Jordan; Rachel H McMahan; Jason Z Oh; Matthew R Pipeling; Drew M Pardoll; Ross M Kedl; John W Kappler; Jill E Slansky
Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):188-97.
2007: Drew M Pardoll
Building the bionic T cell.
Nature medicine 2007;13(12):1411-3.
2007: Tsvetelina Pentcheva-Hoang; Lieping Chen; Drew M Pardoll; James P Allison
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(45):17765-70.
2007: Joseph Grosso; Cristin C Kelleher; Timothy J Harris; Charles H Maris; Edward L Hipkiss; Angelo M DeMarzo; Robert A Anders; GEORGES NETTO; Derese Getnet; Tullia C Bruno; Monica V Goldberg; Drew M Pardoll; Charles G Drake
LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems.
The Journal of clinical investigation 2007;117(11):3383-92.
2007: Kiyoshi Yoshimura; Lindsay S Laird; Christina Y Chia; Kristen F Meckel; Jill E Slansky; John M Thompson; Ajay Jain; Drew M Pardoll; Richard D Schulick
Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory T cells.
Cancer research 2007;67(20):10058-66.
2007: Timothy J Harris; Joseph Grosso; Hung-Rong Yen; Hong Xin; Marcin Kortylewski; Emilia Albesiano; Edward L Hipkiss; Derese Getnet; Monica V Goldberg; Charles H Maris; Franck Housseau; Hua Yu; Drew M Pardoll; Charles G Drake
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4313-7.
2007: Monica V Goldberg; Charles H Maris; Edward L Hipkiss; Andrew S Flies; Lijie Zhen; Rubin M Tuder; Joseph Grosso; Timothy J Harris; Derese Getnet; Katharine A Whartenby; Dirk G Brockstedt; Thomas W Dubensky; Lieping Chen; Drew M Pardoll; Charles G Drake
Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells.
Blood 2007;110(1):186-92.
2007: Fumihiko Tsushima; SHENG YAO; Tae Kwang Shin; Andrew S Flies; Sarah Flies; Haiying Xu; Koji Tamada; Drew M Pardoll; Lieping Chen
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy.
Blood 2007;110(1):180-5.
2007: Shiwen Peng; Cornelia L Trimble; Lee Wu; Drew M Pardoll; Richard B S Roden; Chien-Fu Hung; Tzyy-choou Wu
HLA-DQB1*02-restricted HPV-16 E7 peptide-specific CD4+ T-cell immune responses correlate with regression of HPV-16-associated high-grade squamous intraepithelial lesions.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(8):2479-87.
2007: Ken-Yu Lin; Dan Lu; Chien-Fu Hung; Shiwen Peng; LANQING HUANG; Chunfa Jie; Francisco Martinez Murillo; Jesse Rowley; Ya-Chea Tsai; Liangmei He; Dae-Jin Kim; Elizabeth M Jaffee; Drew M Pardoll; Tzyy-choou Wu
Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion.
Cancer research 2007;67(4):1832-41.
2007: Ignacio Melero; Sandra Hervas-Stubbs; Martin J Glennie; Drew M Pardoll; Lieping Chen
Immunostimulatory monoclonal antibodies for cancer therapy.
Nature reviews. Cancer 2007;7(2):95-106.
2007: Fan Pan; Luo Sun; David B Kardian; Katharine A Whartenby; Drew M Pardoll; Jun O Liu
Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin.
Nature 2007;445(7126):433-6.
2007: Hua Yu; Marcin Kortylewski; Drew M Pardoll
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.
Nature reviews. Immunology 2007;7(1):41-51.
2006: Kristen M Hege; Karin Jooss; Drew M Pardoll
GM-CSF gene-modifed cancer cell immunotherapies: of mice and men.
International reviews of immunology 2006;25(5-6):321-52.
2006: Sudarshan Anand; Pu Wang; Kiyoshi Yoshimura; In-Hak Choi; Anja Hilliard; Youhai H Chen; Chyung-Ru Wang; Richard D Schulick; Andrew S Flies; Dallas B Flies; Gefeng Zhu; Yanhui Xu; Drew M Pardoll; Lieping Chen; Koji Tamada
Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis.
The Journal of clinical investigation 2006;116(4):1045-51.
2006: Rajani Ravi; Ephraim J Fuchs; Ajay Jain; Vui Pham; Kiyoshi Yoshimura; Traci Prouser; Sanju Jalla; Xianzheng Zhou; Elizabeth Garrett-Mayer; Scott H Kaufmann; Richard D Schulick; Drew M Pardoll; Atul Bedi
Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling.
Cancer research 2006;66(3):1730-9.
2006: Camie W Y Chan; Emily Crafton; Hong-Ni Fan; James Flook; Kiyoshi Yoshimura; Mario Skarica; Dirk G Brockstedt; Thomas W Dubensky; Monique F Stins; Lewis L Lanier; Drew M Pardoll; Franck Housseau
Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity.
Nature medicine 2006;12(2):207-13.
2006: Kiyoshi Yoshimura; Ajay Jain; Heather E Allen; Lindsay S Laird; Christina Y Chia; TANNA RAVI; Dirk G Brockstedt; Martin A Giedlin; Keith Bahjat; Meredith L Leong; Jill E Slansky; David N Cook; Thomas W Dubensky; Drew M Pardoll; Richard D Schulick
Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes.
Cancer research 2006;66(2):1096-104.
2006: Charles G Drake; Elizabeth M Jaffee; Drew M Pardoll
Mechanisms of immune evasion by tumors.
Advances in immunology 2006;90():51-81.
2006: Shiwen Peng; Cornelia L Trimble; Liangmei He; Ya-Chea Tsai; Cheng-Tao Lin; David A K Boyd; Drew M Pardoll; Chien-Fu Hung; Tzyy-choou Wu
Characterization of HLA-A2-restricted HPV-16 E7-specific CD8(+) T-cell immune responses induced by DNA vaccines in HLA-A2 transgenic mice.
Gene therapy 2006;13(1):67-77.
2005: Lesniak Maciej; Erin Kelleher; Drew M Pardoll; Yan Cui
Targeted gene therapy to antigen-presenting cells in the central nervous system using hematopoietic stem cells.
Neurological research 2005;27(8):820-6.
2005: Marcin Kortylewski; Maciej Kujawski; Tianhong Wang; Sheng Wei; Shumin Zhang; Shari Pilon-Thomas; Guilian Niu; Heidi Kay; James J Mulé; William G Kerr; Richard Jove; Drew M Pardoll; Hua Yu
Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity.
Nature medicine 2005;11(12):1314-21.
2005: Katharine A Whartenby; Peter A Calabresi; Erin McCadden; Bao Nguyen; David Kardian; Tianhong Wang; Claudio Mosse; Drew M Pardoll; Donald Small
Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16741-6.
2005: Daniel Laheru; Drew M Pardoll; Elizabeth M Jaffee
Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology.
Molecular cancer therapeutics 2005;4(11):1645-52.
2005: Guilian Niu; Kenneth L Wright; Yihong Ma; Gabriela M Wright; Mei Huang; Rosalyn B Irby; Jon Briggs; James Karras; W.Douglas Cress; Drew M Pardoll; Richard Jove; Jiangdong Chen; Hua Yu
Role of Stat3 in regulating p53 expression and function.
Molecular and cellular biology 2005;25(17):7432-40.
2005: JEAN KIM; Allen C Myers; Lieping Chen; Drew M Pardoll; Quynh-Ai Truong-Tran; Andrew Lane; John F McDyer; Lowella Fortuno; Robert P Schleimer
Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells.
American journal of respiratory cell and molecular biology 2005;33(3):280-9.
2005: Josef Mautner; Elizabeth M Jaffee; Drew M Pardoll
Tumor-specific CD4+ T cells from a patient with renal cell carcinoma recognize diverse shared antigens.
International journal of cancer. Journal international du cancer 2005;115(5):752-9.
2005: Cornelia L Trimble; Steven Piantadosi; Patti Gravitt; Brigitte M Ronnett; Ellen S Pizer; Andrea Elko; Barbara Wilgus; William Yutzy; Richard Daniel; Keerti V Shah; Shiwen Peng; Chien-Fu Hung; Richard B S Roden; Tzyy-choou Wu; Drew M Pardoll
Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotype.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(13):4717-23.
2005: Andrea L Cox; Timothy Mosbruger; Georg M Lauer; Drew M Pardoll; David L Thomas; Stuart C Ray
Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C.
Hepatology (Baltimore, Md.) 2005;42(1):104-12.
2005: Andrea L Cox; Timothy Mosbruger; Qing Mao; Zhi Liu; Xiao-Hong Wang; Hung-Chih Yang; John Sidney; Alessandro Sette; Drew M Pardoll; David L Thomas; Stuart C Ray
Cellular immune selection with hepatitis C virus persistence in humans.
The Journal of experimental medicine 2005;201(11):1741-52.
2005: Tae Kwang Shin; Kiyoshi Yoshimura; Takako Shin; Emily Crafton; Haruo Tsuchiya; Franck Housseau; Haruhiko Koseki; Richard D Schulick; Lieping Chen; Drew M Pardoll
In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses.
The Journal of experimental medicine 2005;201(10):1531-41.
2005: Lyudmila Burdelya; Maciej Kujawski; Guilian Niu; Bin Zhong; Tianhong Wang; Shumin Zhang; Marcin Kortylewski; Kenneth Shain; Heidi Kay; Julie Y Djeu; William Dalton; Drew M Pardoll; Sheng Wei; Hua Yu
Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(7):3925-31.
2005: Charles G Drake; Amy D H Doody; Marianne A Mihalyo; Ching-Tai Huang; Erin Kelleher; TANNA RAVI; Edward L Hipkiss; Dallas B Flies; Eugene P Kennedy; Meixiao Long; Patrick W McGary; Lee Coryell; William G Nelson; Drew M Pardoll; Adam J. Adler
Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen.
Cancer cell 2005;7(3):239-49.
2005: Xianzheng Zhou; Do Youn Jun; Amy Morck Thomas; Xin Huang; LANQING HUANG; Josef Mautner; Wa Mo; Paul F Robbins; Drew M Pardoll; Elizabeth M Jaffee
Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccine.
Cancer research 2005;65(3):1079-88.
2004: Rajani Ravi; Ajay Jain; Richard D Schulick; Vui Pham; Traci S Prouser; Heather Allen; Elizabeth Garrett Mayer; Hua Yu; Drew M Pardoll; Avi Ashkenazi; Atul Bedi
Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL.
Cancer research 2004;64(24):9105-14.
2004: Lesniak Maciej; Patrik Gabikian; Betty M. Tyler; Drew M Pardoll; Henry Brem
Dexamethasone mediated inhibition of local IL-2 immunotherapy is dose dependent in experimental brain tumors.
Journal of neuro-oncology 2004;70(1):23-8.
2004: Ching-Tai Huang; Creg J Workman; Dallas B Flies; Xiaoyu Pan; Aimee L Marson; Gang Zhou; Edward L Hipkiss; TANNA RAVI; Jeanne Kowalski; Hyam I Levitsky; Jonathan D Powell; Drew M Pardoll; Charles G Drake; Dario A A Vignali
Role of LAG-3 in regulatory T cells.
Immunity 2004;21(4):503-13.
2004: Drew M Pardoll; James Allison
Cancer immunotherapy: breaking the barriers to harvest the crop.
Nature medicine 2004;10(9):887-92.
2004: Yiping Yang; Ching-Tai Huang; Xiaopei Huang; Drew M Pardoll
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance.
Nature immunology 2004;5(5):508-15.
2004: Koichiro Matsumoto; Hiromasa Inoue; Takako Nakano; Miyuki Tsuda; Yuki Yoshiura; Satoru Fukuyama; Fumihiko Tsushima; Tomoaki Hoshino; Hisamichi Aizawa; Hisaya Akiba; Drew M Pardoll; Nobuyuki Hara; Hideo Yagita; Miyuki Azuma; Yoichi Nakanishi
B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(4):2530-41.
2004: Tianhong Wang; Guilian Niu; Marcin Kortylewski; Lyudmila Burdelya; Kenneth Shain; Shumin Zhang; Raka Bhattacharya; Dmitry I Gabrilovich; Richard Heller; Domenico Coppola; William Dalton; Richard Jove; Drew M Pardoll; Hua Yu
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells.
Nature medicine 2004;10(1):48-54.
2003: Cornelia L Trimble; Cheng-Tao Lin; Chien-Fu Hung; Sara I Pai; Jeremy Juang; Liangmei He; Maura L Gillison; Drew M Pardoll; Lee Wu; Tzyy-choou Wu
Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe.
Vaccine 2003;21(25-26):4036-42.
2003: Kevin Gorski; Tae Kwang Shin; Emily Crafton; Mizuto Otsuji; Frédérique M Rattis; Xin Huang; Erin Kelleher; Loise Francisco; Drew M Pardoll; Haruo Tsuchiya
A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer.
Molecular immunology 2003;40(1):35-47.
2003: Lesniak Maciej; Betty M. Tyler; Drew M Pardoll; Henry Brem
Gene therapy for experimental brain tumors using a xenogenic cell line engineered to secrete hIL-2.
Journal of neuro-oncology 2003;64(1-2):155-60.
2003: Ajay Jain; Jill E Slansky; Laurel C Matey; Heather E Allen; Drew M Pardoll; Richard D Schulick
Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases.
Annals of surgical oncology 2003;10(7):810-20.
2003: Marion Couch; John K Saunders; Bert W O'Malley; Drew M Pardoll; Elizabeth M Jaffee
Spatial distribution of tumor vaccine improves efficacy.
The Laryngoscope 2003;113(8):1401-5.
2003: Pornpan Youngnak; Yuko Kozono; Haruo Kozono; Hideyuki Iwai; Noriko Otsuki; Hisayo Jin; Ken Omura; Hideo Yagita; Drew M Pardoll; Lieping Chen; Miyuki Azuma
Differential binding properties of B7-H1 and B7-DC to programmed death-1.
Biochemical and biophysical research communications 2003;307(3):672-7.
2003: Xianzheng Zhou; Yan Cui; Xin Huang; Zhiwei Yu; Amy M Thomas; Zhaohui Ye; Drew M Pardoll; Elizabeth M Jaffee; Linzhao Cheng
Lentivirus-mediated gene transfer and expression in established human tumor antigen-specific cytotoxic T cells and primary unstimulated T cells.
Human gene therapy 2003;14(11):1089-105.
2003: Tae Kwang Shin; Gene Kennedy; Kevin Gorski; Haruo Tsuchiya; Haruhiko Koseki; Miyuki Azuma; Hideo Yagita; Lieping Chen; Jonathan D Powell; Drew M Pardoll; Franck Housseau
Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor.
The Journal of experimental medicine 2003;198(1):31-8.
2003: Yan Cui; Erin Kelleher; Erin Straley; Ephraim J Fuchs; Kevin Gorski; Hyam I Levitsky; Ivan Borrello; Curt I Civin; Stephen P Schoenberger; Linzhao Cheng; Drew M Pardoll; Katharine A Whartenby
Immunotherapy of established tumors using bone marrow transplantation with antigen gene--modified hematopoietic stem cells.
Nature medicine 2003;9(7):952-8.
2003: Falk Nimmerjahn; Slavoljub Milosevic; Uta Behrends; Elizabeth M Jaffee; Drew M Pardoll; Georg W Bornkamm; Josef Mautner
Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy.
European journal of immunology 2003;33(5):1250-9.
2003: Ching-Tai Huang; David L Huso; Zhenbing Lu; Tianhong Wang; Gang Zhou; Eugene P Kennedy; Charles G Drake; David J Morgan; Linda A Sherman; Amy D Higgins; Drew M Pardoll; Adam J. Adler
CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(8):3945-53.
2003: Marion Couch; John K Saunders; Bert W O'Malley; Drew M Pardoll; Elizabeth M Jaffee
Genetically engineered tumor cell vaccine in a head and neck cancer model.
The Laryngoscope 2003;113(3):552-6.
2003: Suresh Radhakrishnan; Loc T Nguyen; Bogoljub Ciric; Daren R Ure; Bin Zhou; Koji Tamada; Haidong Dong; Su-Yi Tseng; Tae Kwang Shin; Drew M Pardoll; Lieping Chen; Robert A Kyle; Moses Rodriguez; Larry R Pease
Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):1830-8.
2003: Leo Luznik; Jill E Slansky; Sanju Jalla; Ivan Borrello; Hyam I Levitsky; Drew M Pardoll; Ephraim J Fuchs
Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras.
Blood 2003;101(4):1645-52.
2003: Drew M Pardoll
Does the immune system see tumors as foreign or self?
Annual review of immunology 2003;21():807-39.
2002: Tim F Greten; Firouzeh Korangy; Gunnar Neumann; Heiner Wedemeyer; Karola Schlote; Astrid Heller; Stephan Scheffer; Drew M Pardoll; Annette I Garbe; Jonathan P Schneck; Michael P Manns
Peptide-beta2-microglobulin-MHC fusion molecules bind antigen-specific T cells and can be used for multivalent MHC-Ig complexes.
Journal of immunological methods 2002;271(1-2):125-35.
2002: Drew M Pardoll
T cells take aim at cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(25):15840-2.
2002: Drew M Pardoll
Tumor reactive T cells get a boost.
Nature biotechnology 2002;20(12):1207-8.
2002: Loc T Nguyen; Suresh Radhakrishnan; Bogoljub Ciric; Koji Tamada; Tae Kwang Shin; Drew M Pardoll; Lieping Chen; Moses Rodriguez; Larry R Pease
Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.
The Journal of experimental medicine 2002;196(10):1393-8.
2002: Yamazaki Tomohide; Hisaya Akiba; Hideyuki Iwai; Hironori Matsuda; Mami Aoki; Yuka Tanno; Tae Kwang Shin; Haruo Tsuchiya; Drew M Pardoll; Ko Okumura; Miyuki Azuma; Hideo Yagita
Expression of programmed death 1 ligands by murine T cells and APC.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5538-45.
2002: Katharine A Whartenby; Erin E Straley; Heeje Kim; Frederick Racke; Tanavde Vivek; Kevin Gorski; Linzhao Cheng; Drew M Pardoll; Curt I Civin
Transduction of donor hematopoietic stem-progenitor cells with Fas ligand enhanced short-term engraftment in a murine model of allogeneic bone marrow transplantation.
Blood 2002;100(9):3147-54.
2002: Richard E Clatterbuck; Eric M Oshiro; Patricia A Hoffman; Gregory N Dietsch; Drew M Pardoll; Rafael J Tamargo
Inhibition of vasospasm with lymphocyte function-associated antigen-1 monoclonal antibody in a femoral artery model in rats.
Journal of neurosurgery 2002;97(3):676-82.
2002: Xiang-Yang Wang; Ying Li; Masoud H Manjili; Elizabeth A Repasky; Drew M Pardoll; John R Subjeck
Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor.
Cancer immunology, immunotherapy : CII 2002;51(6):311-9.
2002: Ryan A Wilcox; Andrei I Chapoval; Kevin Gorski; Mizuto Otsuji; Tae Kwang Shin; Dallas B Flies; Koji Tamada; Robert S Mittler; Haruo Tsuchiya; Drew M Pardoll; Lieping Chen
Cutting edge: Expression of functional CD137 receptor by dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4262-7.
2002: Drew M Pardoll
Spinning molecular immunology into successful immunotherapy.
Nature reviews. Immunology 2002;2(4):227-38.
2002: Ivan Borrello; Drew M Pardoll
GM-CSF-based cellular vaccines: a review of the clinical experience.
Cytokine & growth factor reviews 2002;13(2):185-93.
2002: Guilian Niu; Kenneth L Wright; Mei Huang; Lanxi Song; Eric Haura; James Turkson; Shumin Zhang; Tianhong Wang; Dominic Sinibaldi; Domenico Coppola; Richard Heller; Lee M Ellis; James Karras; Jacqueline F Bromberg; Drew M Pardoll; Richard Jove; Hua Yu
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis.
Oncogene 2002;21(13):2000-8.
2002: Franck Housseau; Daniel A Langer; Samuel D Oberholtzer; Anitha Moorthy; Hyam I Levitsky; Drew M Pardoll; Suzanne Topalian
Tumor-specific CD8+ T lymphocytes derived from the peripheral blood of prostate cancer patients by in vitro stimulation with autologous tumor cell lines.
International journal of cancer. Journal international du cancer 2002;98(1):57-62.
2002: Charles G Drake; Drew M Pardoll
Tumor immunology--towards a paradigm of reciprocal research.
Seminars in cancer biology 2002;12(1):73-80.
2002: Yan Cui; Jonathan Golob; Erin Kelleher; Zhaohui Ye; Drew M Pardoll; Linzhao Cheng
Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem/progenitor cells.
Blood 2002;99(2):399-408.
2002: Maria G Sotomayor; Hua Yu; Scott J Antonia; Eduardo M Sotomayor; Drew M Pardoll
Advances in gene therapy for malignant melanoma.
Cancer control : journal of the Moffitt Cancer Center 2002;9(1):39-48.
2001: Drew M Pardoll
Immunology. Stress, NK receptors, and immune surveillance.
Science (New York, N.Y.) 2001;294(5542):534-6.
2001: SM O'Herrin; Jill E Slansky; Q Tang; Mary A. Markiewicz; Thomas F Gajewski; Drew M Pardoll; Jonathan P Schneck; Jeffrey A Bluestone
Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(5):2555-60.
2001: Justin Hanes; AK Sills; Z Zhao; KW Suh; Betty M. Tyler; Francesco DiMeco; Daniel J Brat; Michael A Choti; K W Leong; Drew M Pardoll; Henry Brem
Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors.
Pharmaceutical research 2001;18(7):899-906.
2001: Denise Golgher; Firouzeh Korangy; B Gao; Kevin Gorski; Elizabeth M Jaffee; Michael Edidin; Drew M Pardoll; Tim Elliott
An immunodominant MHC class II-restricted tumor antigen is conformation dependent and binds to the endoplasmic reticulum chaperone, calreticulin.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(1):147-55.
2001: Drew M Pardoll
T cells and tumours.
Nature 2001;411(6841):1010-2.
2001: Abdel Rahim A Hamad; A Srikrishnan; P Mirmonsef; C P Broeren; Carl H June; Drew M Pardoll; Jonathan P Schneck
Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunity.
The Journal of experimental medicine 2001;193(10):1113-21.
2001: D S Tendler; Clare Bao; Tianhong Wang; E L Huang; Edward Ratovitski; Drew M Pardoll; Charles J Lowenstein
Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.
Cancer research 2001;61(9):3682-8.
2001: S Y Tseng; Mizuto Otsuji; Kevin Gorski; Xin Huang; Jill E Slansky; Sara I Pai; A Shalabi; Tae Kwang Shin; Drew M Pardoll; Haruo Tsuchiya
B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
The Journal of experimental medicine 2001;193(7):839-46.
2001: C M Gérard; N Baudson; K Kraemer; C Bruck; N Garçon; Yvonne Paterson; Zhixing K Pan; Drew M Pardoll
Therapeutic potential of protein and adjuvant vaccinations on tumour growth.
Vaccine 2001;19(17-19):2583-9.
2001: C M Gérard; N Baudson; K Kraemer; C Ledent; Drew M Pardoll; C Bruck
Recombinant human papillomavirus type 16 E7 protein as a model antigen to study the vaccine potential in control and E7 transgenic mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3 Suppl):838s-847s.
2001: CH Chen; Tian-Li Wang; Hongxiu Ji; Chien-Fu Hung; Drew M Pardoll; Wen-Fang Cheng; Morris Ling; Tzyy-choou Wu
Recombinant DNA vaccines protect against tumors that are resistant to recombinant vaccinia vaccines containing the same gene.
Gene therapy 2001;8(2):128-38.
2001: Elizabeth M Jaffee; Ralph Hruban; Barbara A Biedrzycki; Daniel Laheru; K Schepers; P R Sauter; M Goemann; JoAnn Coleman; Louise B. Grochow; Ross C Donehower; Keith D Lillemoe; Seamus O'Reilly; Ross A. Abrams; Drew M Pardoll; John L Cameron; Charles J Yeo
Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(1):145-56.
2000: Jill E Slansky; FM Rattis; L F Boyd; Tarek M Fahmy; Elizabeth M Jaffee; Jonathan P Schneck; David Margulies; Drew M Pardoll
Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complex.
Immunity 2000;13(4):529-38.
2000: Matthew G Ewend; R C Thompson; R Anderson; AK Sills; K Staveley-O'Carroll; Betty M. Tyler; Justin Hanes; Daniel J Brat; M Thomas; Elizabeth M Jaffee; Drew M Pardoll; Henry Brem
Intracranial paracrine interleukin-2 therapy stimulates prolonged antitumor immunity that extends outside the central nervous system.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2000;23(4):438-48.
2000: CH Chen; KW Suh; Hongxiu Ji; Michael A Choti; Drew M Pardoll; Tzyy-choou Wu
Antigen-specific immunotherapy for human papillomavirus 16 E7-expressing tumors grown in the liver.
Journal of hepatology 2000;33(1):91-8.
2000: E Y Chang; C H Chen; Hongxiu Ji; Tian-Li Wang; K Hung; B P Lee; Alex Yee-Chen Huang; Robert J Kurman; Drew M Pardoll; Tzyy-choou Wu
Antigen-specific cancer immunotherapy using a GM-CSF secreting allogeneic tumor cell-based vaccine.
International journal of cancer. Journal international du cancer 2000;86(5):725-30.
2000: Tian-Li Wang; Morris Ling; Ie-Ming Shih; T Pham; Sara I Pai; Z Lu; Robert J Kurman; Drew M Pardoll; Tzyy-choou Wu
Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity.
Gene therapy 2000;7(9):726-33.
2000: CH Chen; Tian-Li Wang; Chien-Fu Hung; Drew M Pardoll; Tzyy-choou Wu
Boosting with recombinant vaccinia increases HPV-16 E7-specific T cell precursor frequencies of HPV-16 E7-expressing DNA vaccines.
Vaccine 2000;18(19):2015-22.
2000: Drew M Pardoll
Therapeutic vaccination for cancer.
Clinical immunology (Orlando, Fla.) 2000;95(1 Pt 2):S44-62.
2000: Francesco DiMeco; Laurence D Rhines; Justin Hanes; Betty M. Tyler; Daniel J Brat; E Torchiana; Michael Guarnieri; M P Colombo; Drew M Pardoll; Gaetano Finocchiaro; Henry Brem; Alessandro Olivi
Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats.
Journal of neurosurgery 2000;92(3):419-27.
2000: CH Chen; Tian-Li Wang; Chien-Fu Hung; Y Yang; R A Young; Drew M Pardoll; Tzyy-choou Wu
Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene.
Cancer research 2000;60(4):1035-42.
2000: Z Lu; L Yuan; X Zhou; Eduardo M Sotomayor; Hyam I Levitsky; Drew M Pardoll
CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes.
The Journal of experimental medicine 2000;191(3):541-50.
2000: Adam J. Adler; Ching-Tai Huang; Gregory S Yochum; D W Marsh; Drew M Pardoll
In vivo CD4+ T cell tolerance induction versus priming is independent of the rate and number of cell divisions.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):649-55.
2000: Lesniak Maciej; Prakash Sampath; Francesco DiMeco; Michael P Viglione; Betty M. Tyler; Drew M Pardoll; Henry Brem
Comparative analysis of paracrine immunotherapy in experimental brain tumors.
Neurosurgical focus 2000;9(6):e4.
1999: CH Chen; Hongxiu Ji; KW Suh; Michael A Choti; Drew M Pardoll; Tzyy-choou Wu
Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs.
Gene therapy 1999;6(12):1972-81.
1999: Liisa K Selin; MY Lin; K A Kraemer; Drew M Pardoll; Jonathan P Schneck; SM Varga; P A Santolucito; Amelia K Pinto; Raymond M Welsh
Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses.
Immunity 1999;11(6):733-42.
1999: KW Suh; Steven Piantadosi; H A Yazdi; Drew M Pardoll; Henry Brem; Michael A Choti
Treatment of liver metastases from colon carcinoma with autologous tumor vaccine expressing granulocyte-macrophage colony-stimulating factor.
Journal of surgical oncology 1999;72(4):218-24.
1999: Hongxiu Ji; Tian-Li Wang; CH Chen; Sara I Pai; Chien-Fu Hung; Ken-Yu Lin; Robert J Kurman; Drew M Pardoll; Tzyy-choou Wu
Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors.
Human gene therapy 1999;10(17):2727-40.
1999: Drew M Pardoll
Inducing autoimmune disease to treat cancer.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5340-2.
1999: Prakash Sampath; Justin Hanes; Francesco DiMeco; Betty M. Tyler; Daniel J Brat; Drew M Pardoll; Henry Brem
Paracrine immunotherapy with interleukin-2 and local chemotherapy is synergistic in the treatment of experimental brain tumors.
Cancer research 1999;59(9):2107-14.
1999: MS Lebowitz; SM O'Herrin; Abdel Rahim A Hamad; Tarek M Fahmy; D Marguet; N C Barnes; Drew M Pardoll; Joan G Bieler; Jonathan P Schneck
Soluble, high-affinity dimers of T-cell receptors and class II major histocompatibility complexes: biochemical probes for analysis and modulation of immune responses.
Cellular immunology 1999;192(2):175-84.
1999: Bert W O'Malley; Dechun Li; A Buckner; L Duan; Savio L-Y. Woo; Drew M Pardoll
Limitations of adenovirus-mediated interleukin-2 gene therapy for oral cancer.
The Laryngoscope 1999;109(3):389-95.
1998: K Hung; R Hayashi; Anne Lafond-Walker; Charles J Lowenstein; Drew M Pardoll; Hyam I Levitsky
The central role of CD4(+) T cells in the antitumor immune response.
The Journal of experimental medicine 1998;188(12):2357-68.
1998: Abdel Rahim A Hamad; SM O'Herrin; MS Lebowitz; A Srikrishnan; Joan G Bieler; Jonathan P Schneck; Drew M Pardoll
Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor.
The Journal of experimental medicine 1998;188(9):1633-40.
1998: Drew M Pardoll; Suzanne Topalian
The role of CD4+ T cell responses in antitumor immunity.
Current opinion in immunology 1998;10(5):588-94.
1998: Hongxiu Ji; E Y Chang; Ken-Yu Lin; Robert J Kurman; Drew M Pardoll; Tzyy-choou Wu
Antigen-specific immunotherapy for murine lung metastatic tumors expressing human papillomavirus type 16 E7 oncoprotein.
International journal of cancer. Journal international du cancer 1998;78(1):41-5.
1998: Elizabeth M Jaffee; RHODA ABRAMS; John L Cameron; Ross C Donehower; M Duerr; J Gossett; Tim F Greten; Louise B. Grochow; Ralph Hruban; Scott E Kern; Keith D Lillemoe; Seamus O'Reilly; Drew M Pardoll; Henry A Pitt; Patricia A Sauter; C Weber; C Yeo
A phase I clinical trial of lethally irradiated allogeneic pancreatic tumor cells transfected with the GM-CSF gene for the treatment of pancreatic adenocarcinoma.
Human gene therapy 1998;9(13):1951-71.
1998: Tim F Greten; Jill E Slansky; Ryuji Kubota; Samantha S Soldan; Elizabeth M Jaffee; Thomas P Leist; Drew M Pardoll; Steven Jacobson; Jonathan P Schneck
Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7568-73.
1998: Adam J. Adler; D W Marsh; Gregory S Yochum; J L Guzzo; A Nigam; William G Nelson; Drew M Pardoll
CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells.
The Journal of experimental medicine 1998;187(10):1555-64.
1998: Drew M Pardoll
Cancer vaccines.
Nature medicine 1998;4(5 Suppl):525-31.
1998: M C Thomas; Tim F Greten; Drew M Pardoll; Elizabeth M Jaffee
Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine.
Human gene therapy 1998;9(6):835-43.
1998: K Staveley-O'Carroll; Eduardo M Sotomayor; J Montgomery; Ivan Borrello; L Hwang; S Fein; Drew M Pardoll; Hyam I Levitsky
Induction of antigen-specific T cell anergy: An early event in the course of tumor progression.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(3):1178-83.
1998: David J Morgan; Huub T C Kreuwel; S Fleck; Hyam I Levitsky; Drew M Pardoll; Linda A Sherman
Activation of low avidity CTL specific for a self epitope results in tumor rejection but not autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(2):643-51.
1998: A Nigam; R F Yacavone; M L Zahurak; C M Johns; Drew M Pardoll; Steven Piantadosi; Hyam I Levitsky; William G Nelson
Immunomodulatory properties of antineoplastic drugs administered in conjunction with GM-CSF-secreting cancer cell vaccines.
International journal of oncology 1998;12(1):161-70.
1997: Eric M Oshiro; Patricia A Hoffman; Gregory N Dietsch; M C Watts; Drew M Pardoll; Rafael J Tamargo
Inhibition of experimental vasospasm with anti-intercellular adhesion molecule-1 monoclonal antibody in rats.
Stroke; a journal of cerebral circulation 1997;28(10):2031-7; discussion 2037-8.
1997: Elizabeth M Jaffee; Drew M Pardoll
Considerations for the clinical development of cytokine gene-transduced tumor cell vaccines.
Methods (San Diego, Calif.) 1997;12(2):143-53.
1997: Drew M Pardoll
Maturation of cancer vaccines. A meeting report on 'Cancer Vaccines 1996,' sponsored by the Cancer Research Institute, held October 7-9, 1996.
Biochimica et biophysica acta 1997;1332(2):R33-6.
1997: Jonathan W Simons; Elizabeth M Jaffee; CE Weber; Hyam I Levitsky; William G Nelson; Michael A Carducci; A J Lazenby; LK Cohen; C C Finn; Shirley Clift; K M Hauda; Lisa A Beck; KM Leiferman; A H Owens; Steven Piantadosi; Glenn Dranoff; Richard C Mulligan; Drew M Pardoll; Fray F Marshall
Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer.
Cancer research 1997;57(8):1537-46.
1996: R C Thompson; Drew M Pardoll; Elizabeth M Jaffee; M G Ewend; M C Thomas; Betty M. Tyler; Henry Brem
Systemic and local paracrine cytokine therapies using transduced tumor cells are synergistic in treating intracranial tumors.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1996;19(6):405-13.
1996: Elizabeth M Jaffee; Drew M Pardoll
Murine tumor antigens: is it worth the search?
Current opinion in immunology 1996;8(5):622-7.
1996: Alex Yee-Chen Huang; PH Gulden; Amina S Woods; M C Thomas; C D Tong; W Wang; Victor H Engelhard; Gary R Pasternack; Robert J Cotter; D Hunt; Drew M Pardoll; Elizabeth M Jaffee
The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9730-5.
1996: M M Fort; Drew M Pardoll
Can bone marrow-derived thymic stromal cells mediate the positive selection of class I-restricted T cells?
Cellular immunology 1996;171(1):74-9.
1996: Elizabeth M Jaffee; M C Thomas; Alex Yee-Chen Huang; K M Hauda; Hyam I Levitsky; Drew M Pardoll
Enhanced immune priming with spatial distribution of paracrine cytokine vaccines.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1996;19(3):176-83.
1996: Alex Yee-Chen Huang; Allen Bruce; Drew M Pardoll; Hyam I Levitsky
In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter.
Immunity 1996;4(4):349-55.
1996: Drew M Pardoll
Releasing the brakes on antitumor immune response.
Science (New York, N.Y.) 1996;271(5256):1691.
1996: Alex Yee-Chen Huang; Allen Bruce; Drew M Pardoll; Hyam I Levitsky
Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?
The Journal of experimental medicine 1996;183(3):769-76.
1996: K Y Lin; F G Guarnieri; K Staveley-O'Carroll; Hyam I Levitsky; Thomas J August; Drew M Pardoll; Tzyy-choou Wu
Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.
Cancer research 1996;56(1):21-6.
1995: Tzyy-choou Wu; F G Guarnieri; K Staveley-O'Carroll; Raphael P Viscidi; Hyam I Levitsky; L Hedrick; Kathleen R Cho; Thomas J August; Drew M Pardoll
Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11671-5.
1995: Tzyy-choou Wu; Alex Yee-Chen Huang; Elizabeth M Jaffee; Hyam I Levitsky; Drew M Pardoll
A reassessment of the role of B7-1 expression in tumor rejection.
The Journal of experimental medicine 1995;182(5):1415-21.
1995: Z K Pan; G Ikonomidis; Drew M Pardoll; Yvonne Paterson
Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine.
Cancer research 1995;55(21):4776-9.
1995: Drew M Pardoll; A M Beckerleg
Exposing the immunology of naked DNA vaccines.
Immunity 1995;3(2):165-9.
1995: Elizabeth M Jaffee; Audrey Lazenby; J Meurer; F Marshall; K M Hauda; C Counts; H Hurwitz; Jonathan W Simons; Hyam I Levitsky; Drew M Pardoll
Use of murine models of cytokine-secreting tumor vaccines to study feasibility and toxicity issues critical to designing clinical trials.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1995;18(1):1-9.
1995: Z K Pan; G Ikonomidis; Audrey Lazenby; Drew M Pardoll; Yvonne Paterson
A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours.
Nature medicine 1995;1(5):471-7.
1995: Amina S Woods; Alex Yee-Chen Huang; Robert J Cotter; Gary R Pasternack; Drew M Pardoll; Elizabeth M Jaffee
Simplified high-sensitivity sequencing of a major histocompatibility complex class I-associated immunoreactive peptide using matrix-assisted laser desorption/ionization mass spectrometry.
Analytical biochemistry 1995;226(1):15-25.
1995: Martin G Sanda; Nicholas P Restifo; J C Walsh; Y Kawakami; William G Nelson; Drew M Pardoll; Jonathan W Simons
Molecular characterization of defective antigen processing in human prostate cancer.
Journal of the National Cancer Institute 1995;87(4):280-5.
1995: Elizabeth M Jaffee; Drew M Pardoll
Gene therapy: its potential applications in the treatment of renal-cell carcinoma.
Seminars in oncology 1995;22(1):81-91.
1995: Drew M Pardoll
Paracrine cytokine adjuvants in cancer immunotherapy.
Annual review of immunology 1995;13():399-415.
1994: Drew M Pardoll
Tumour antigens. A new look for the 1990s.
Nature 1994;369(6479):357.
1994: Alex Yee-Chen Huang; P Golumbek; M Ahmadzadeh; Elizabeth M Jaffee; Drew M Pardoll; Hyam I Levitsky
Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens.
Science (New York, N.Y.) 1994;264(5161):961-5.
1994: Hyam I Levitsky; Audrey Lazenby; R J Hayashi; Drew M Pardoll
In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.
The Journal of experimental medicine 1994;179(4):1215-24.
1994: K B Urdahl; Drew M Pardoll; Marc K Jenkins
Cyclosporin A inhibits positive selection and delays negative selection in alpha beta TCR transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(6):2853-9.
1994: Martin G Sanda; S R Ayyagari; Elizabeth M Jaffee; Jonathan I Epstein; S L Clift; LK Cohen; Glenn Dranoff; Drew M Pardoll; Richard C Mulligan; Jonathan W Simons
Demonstration of a rational strategy for human prostate cancer gene therapy.
The Journal of urology 1994;151(3):622-8.
1994: Alex Yee-Chen Huang; P Golumbek; M Ahmadzadeh; Elizabeth M Jaffee; Drew M Pardoll; Hyam I Levitsky
Bone marrow-derived cells present MHC class I-restricted tumour antigens in priming of antitumour immune responses.
Ciba Foundation symposium 1994;187():229-40; discussion 240-4.
1993: P T Golumbek; R Azhari; Elizabeth M Jaffee; Hyam I Levitsky; Audrey Lazenby; K Leong; Drew M Pardoll
Controlled release, biodegradable cytokine depots: a new approach in cancer vaccine design.
Cancer research 1993;53(24):5841-4.
1993: Drew M Pardoll
New strategies for enhancing the immunogenicity of tumors.
Current opinion in immunology 1993;5(5):719-25.
1993: Drew M Pardoll
Genetically engineered tumor vaccines.
Annals of the New York Academy of Sciences 1993;690():301-10.
1993: A M Yeager; C Shinn; M Shinohara; Drew M Pardoll
Hematopoietic cell transplantation in the twitcher mouse. The effects of pretransplant conditioning with graded doses of busulfan.
Transplantation 1993;56(1):185-90.
1993: Drew M Pardoll
Cancer vaccines.
Immunology today 1993;14(6):310-6.
1993: Elizabeth M Jaffee; Glenn Dranoff; LK Cohen; K M Hauda; Shirley Clift; Fray F Marshall; Richard C Mulligan; Drew M Pardoll
High efficiency gene transfer into primary human tumor explants without cell selection.
Cancer research 1993;53(10 Suppl):2221-6.
1993: Drew M Pardoll
Cancer vaccines.
Trends in pharmacological sciences 1993;14(5):202-8.
1993: Glenn Dranoff; Elizabeth M Jaffee; Audrey Lazenby; P Golumbek; Hyam I Levitsky; K Brose; V Jackson; H Hamada; Drew M Pardoll; Richard C Mulligan
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3539-43.
1993: P Golumbek; Hyam I Levitsky; L Jaffee; Drew M Pardoll
The antitumor immune response as a problem of self-nonself discrimination: implications for immunotherapy.
Immunologic research 1993;12(2):183-92.
1992: Drew M Pardoll
Immunotherapy with cytokine gene-transduced tumor cells: the next wave in gene therapy for cancer.
Current opinion in oncology 1992;4(6):1124-9.
1992: K B Urdahl; Drew M Pardoll; Marc K Jenkins
Self-reactive T cells are present in the peripheral lymphoid tissues of cyclosporin A-treated mice.
International immunology 1992;4(12):1341-9.
1992: Ana Carrera; S B Wee; Thomas M Roberts; Drew M Pardoll
Selective association between MHC class I-restricted T cell receptors, CDS, and activated tyrosine kinases on thymocytes undergoing positive selection.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(10):3142-9.
1992: P T Golumbek; Fayez M Hamzeh; Elizabeth M Jaffee; Hyam I Levitsky; Paul S Lietman; Drew M Pardoll
Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1992;12(4):224-30.
1992: Drew M Pardoll
New strategies for active immunotherapy with genetically engineered tumor cells.
Current opinion in immunology 1992;4(5):619-23.
1992: Ana Carrera; C Baker; Thomas M Roberts; Drew M Pardoll
Tyrosine kinase triggering in thymocytes undergoing positive selection.
European journal of immunology 1992;22(9):2289-94.
1992: F Heuze; Drew M Pardoll; Elisabeth Diez; S Ezine; Francine Jotereau
Molecular analysis of a pro-T cell clone transformed by Abelson-murine leukemia virus, displaying progressive gamma delta T cell receptor gene rearrangement and surface expression.
European journal of immunology 1992;22(8):2077-84.
1992: Drew M Pardoll; A Carrera
Thymic selection.
Current opinion in immunology 1992;4(2):162-5.
1992: Drew M Pardoll; P Golumbek; Hyam I Levitsky; L Jaffee
Molecular engineering of the antitumor immune response.
Bone marrow transplantation 1992;9 Suppl 1():182-6.
1991: A M Yeager; C Shinn; Drew M Pardoll
Lymphoid reconstitution after transplantation of congenic hematopoietic cells in busulfan-treated mice.
Blood 1991;78(12):3312-6.
1991: P T Golumbek; Audrey Lazenby; Hyam I Levitsky; L M Jaffee; H Karasuyama; M Baker; Drew M Pardoll
Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.
Science (New York, N.Y.) 1991;254(5032):713-6.
1991: W Matthews; Craig T Jordan; G W Wiegand; Drew M Pardoll; Ihor R Lemischka
A receptor tyrosine kinase specific to hematopoietic stem and progenitor cell-enriched populations.
Cell 1991;65(7):1143-52.
1991: Hyam I Levitsky; P T Golumbek; Drew M Pardoll
The fate of CD4-8- T cell receptor-alpha beta+ thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(4):1113-7.
1990: T Saito; Drew M Pardoll; B J Fowlkes; Hiroshi Ohno
A murine thymocyte clone expressing gamma delta T cell receptor mediates natural killer-like cytolytic function and TH1-like lymphokine production.
Cellular immunology 1990;131(2):284-301.
1990: Eric R Fearon; Drew M Pardoll; T Itaya; P Golumbek; Hyam I Levitsky; J W Simons; H Karasuyama; Bert Vogelstein; P Frost
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response.
Cell 1990;60(3):397-403.
1990: J C Zůñiga-Pflücker; Kendall A Smith; L Tentori; Drew M Pardoll; Dan Longo; A M Kruisbeek
Are the IL-2 receptors expressed in the murine fetal thymus functional?
Developmental immunology 1990;1(1):59-66.
1990: Ellen A Robey; B J Fowlkes; Drew M Pardoll
Molecular mechanisms for lineage commitment in T cell development.
Seminars in immunology 1990;2(1):25-34.
1989: E M Janis; S H Kaufmann; Ronald H Schwartz; Drew M Pardoll
Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis.
Science (New York, N.Y.) 1989;244(4905):713-6.
1989: B J Fowlkes; Drew M Pardoll
Molecular and cellular events of T cell development.
Advances in immunology 1989;44():207-64.
1988: Marc K Jenkins; Ronald H Schwartz; Drew M Pardoll
Effects of cyclosporine A on T cell development and clonal deletion.
Science (New York, N.Y.) 1988;241(4873):1655-8.
1988: B J Fowlkes; Ronald H Schwartz; Drew M Pardoll
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage.
Nature 1988;334(6183):620-3.
1988: R Q Cron; F Koning; W L Maloy; Drew M Pardoll; John E Coligan; J A Bluestone
Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor gamma delta structures.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(4):1074-82.
1988: Drew M Pardoll; B J Fowlkes; A M Lew; W L Maloy; M A Weston; J A Bluestone; Ronald H Schwartz; J E Coligan; A M Kruisbeek
Thymus-dependent and thymus-independent developmental pathways for peripheral T cell receptor-gamma delta-bearing lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(12):4091-6.
1988: L Tentori; Drew M Pardoll; J C Zuñiga; J Hu-Li; William Paul; J A Bluestone; A M Kruisbeek
Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(4):1089-94.
1988: F Koning; A M Kruisbeek; W L Maloy; S Marusic-Galesic; Drew M Pardoll; E M Shevach; G Stingl; R Valas; W M Yokoyama; John E Coligan
T cell receptor gamma/delta chain diversity.
The Journal of experimental medicine 1988;167(2):676-81.
1988: S Marusić-Galesić; Drew M Pardoll; T Saito; O Leo; B J Fowlkes; John E Coligan; Ronald N Germain; R H Schwartz; A M Kruisbeek
Activation properties of T cell receptor-gamma delta hybridomas expressing diversity in both gamma- and delta-chains.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(2):411-8.
1987: B J Fowlkes; A M Kruisbeek; H Ton-That; M A Weston; J E Coligan; Ronald H Schwartz; Drew M Pardoll
A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.
Nature 1987;329(6136):251-4.
1987: Drew M Pardoll; A M Kruisbeek; B J Fowlkes; J E Coligan; R H Schwartz
The unfolding story of T cell receptor gamma.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1987;1(2):103-9.
1987: M K Jenkins; Drew M Pardoll; J Mizuguchi; T M Chused; R H Schwartz
Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(15):5409-13.
1987: Drew M Pardoll; B J Fowlkes; R I Lechler; R N Germain; R H Schwartz
Early genetic events in T cell development analyzed by in situ hybridization.
The Journal of experimental medicine 1987;165(6):1624-38.
1987: J A Bluestone; Drew M Pardoll; S O Sharrow; B J Fowlkes
Characterization of murine thymocytes with CD3-associated T-cell receptor structures.
Nature 1987;326(6108):82-4.
1987: Drew M Pardoll; B J Fowlkes; J A Bluestone; A Kruisbeek; W L Maloy; J E Coligan; R H Schwartz
Differential expression of two distinct T-cell receptors during thymocyte development.
Nature 1987;326(6108):79-81.
1987: Eric R Fearon; J A Winkelstein; Curt I Civin; Drew M Pardoll; Bert Vogelstein
Carrier detection in X-linked agammaglobulinemia by analysis of X-chromosome inactivation.
The New England journal of medicine 1987;316(8):427-31.
1987: Marc K Jenkins; Drew M Pardoll; J Mizuguchi; H Quill; R H Schwartz
T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state.
Immunological reviews 1987;95():113-35.
1987: Drew M Pardoll; A M Lew; W L Maloy; B J Fowlkes; A Kruisbeek; J A Bluestone; R H Schwartz; J E Coligan
Analysis of T-cell receptor gamma chain expression in the thymus.
Advances in experimental medicine and biology 1987;225():241-6.
1986: A M Lew; Drew M Pardoll; W L Maloy; B J Fowlkes; A Kruisbeek; S F Cheng; R N Germain; J A Bluestone; R H Schwartz; J E Coligan
Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes.
Science (New York, N.Y.) 1986;234(4782):1401-5.
1986: B A Zehnbauer; Drew M Pardoll; P J Burke; M L Graham; Bert Vogelstein
Immunoglobulin gene rearrangements in remission bone marrow specimens from patients with acute lymphoblastic leukemia.
Blood 1986;67(3):835-8.
1982: Drew M Pardoll; R J Rodeheffer; R R Smith; S Charache
Aplastic crisis due to extensive bone marrow necrosis in sickle cell disease.
Archives of internal medicine 1982;142(12):2223-5.
1982: Drew M Pardoll; S Charache; Brian Hjelle; R Jones; J A Phillips; R R Smith; R J Rodeheffer
Homozygous alpha thalassemia/Hb G Philadelphia.
Hemoglobin 1982;6(5):503-15.
1980: Barry D Nelkin; Drew M Pardoll; Bert Vogelstein
Localization of SV40 genes within supercoiled loop domains.
Nucleic acids research 1980;8(23):5623-33.
1980: Bert Vogelstein; Drew M Pardoll; Donald S Coffey
Supercoiled loops and eucaryotic DNA replicaton.
Cell 1980;22(1 Pt 1):79-85.
1980: Drew M Pardoll; Bert Vogelstein
Sequence analysis of nuclear matrix associated DNA from rat liver.
Experimental cell research 1980;128(2):466-70.
1980: Drew M Pardoll; Bert Vogelstein; Donald S Coffey
A fixed site of DNA replication in eucaryotic cells.
Cell 1980;19(2):527-36.
1978: J H Shaper; Drew M Pardoll; S H Kaufmann; Evelyn Barrack; Bert Vogelstein; Donald S Coffey
The relationship of the nuclear matrix to cellular structure and function.
Advances in enzyme regulation 1978;17():213-48.
1976: H Berger; Drew M Pardoll
Evidence that mismatched bases in heteroduplex T4 bacteriophage are recognized in vivo.
Journal of virology 1976;20(2):441-5.