William Pardridge

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TOP 3
Boado Ruben J; Hui Eric K-W; Lu Jeff Zhiqiang; Pardridge William M
AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys.
Pardridge William M; Boado Ruben J
Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery.
Pardridge William M
Alzheimer's disease drug development and the problem of the blood-brain barrier.

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All Publications

2009: Boado Ruben J; Hui Eric K-W; Lu Jeff Zhiqiang; Pardridge William M
AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys.
Journal of biotechnology 2009;144(2):135-41.
2009: Pardridge William M; Boado Ruben J
Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery.
Pharmaceutical research 2009;26(10):2227-36.
2009: Pardridge William M
Alzheimer's disease drug development and the problem of the blood-brain barrier.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2009;5(5):427-32.
2009: Hui Eric Ka-Wai; Boado Ruben J; Pardridge William M
Tumor necrosis factor receptor-IgG fusion protein for targeted drug delivery across the human blood-brain barrier.
Molecular pharmaceutics 2009;6(5):1536-43.
2009: Zhang Yun; Pardridge William M
Near complete rescue of experimental Parkinson's disease with intravenous, non-viral GDNF gene therapy.
Pharmaceutical research 2009;26(5):1059-63.
2009: Xia Chun-Fang; Boado Ruben J; Pardridge William M
Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology.
Molecular pharmaceutics 2009;6(3):747-51.
2009: Boado Ruben J; Zhang Yun; Wang Yuntao; Pardridge William M
Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse.
Biotechnology and bioengineering 2009;102(4):1251-8.
2008: Boado Ruben J; Zhang Yun; Zhang Yufeng; Wang Yuntao; Pardridge William M
IgG-paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier.
Molecular pharmaceutics 2008;5(6):1037-43.
2008: Pardridge William M
Re-engineering biopharmaceuticals for delivery to brain with molecular Trojan horses.
Bioconjugate chemistry 2008;19(7):1327-38.
2008: Boado Ruben J; Zhang Yun; Zhang Yufeng; Wang Yuntao; Pardridge William M
GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier.
Biotechnology and bioengineering 2008;100(2):387-96.
2008: Boado Ruben J; Zhang Yufeng; Zhang Yun; Xia Chun-fang; Wang Yuntao; Pardridge William M
Genetic engineering, expression, and activity of a chimeric monoclonal antibody-avidin fusion protein for receptor-mediated delivery of biotinylated drugs in humans.
Bioconjugate chemistry 2008;19(3):731-9.
2008: Xia Chun-Fang; Boado Ruben J; Zhang Yun; Chu Chun; Pardridge William M
Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter.
The journal of gene medicine 2008;10(3):306-15.
2008: Boado Ruben J; Zhang Yun; Zhang Yufeng; Xia Chun-Fang; Wang Yuntao; Pardridge William M
Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier.
Biotechnology and bioengineering 2008;99(2):475-84.
2008: Chu Chun; Li Jian Yi; Boado Ruben J; Pardridge William M
Blood-brain barrier genomics and cloning of a novel organic anion transporter.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):291-301.
2008: Zhang Yun; Wang Yuntao; Boado Ruben J; Pardridge William M
Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer.
Pharmaceutical research 2008;25(2):400-6.
2007: Xia Chun-Fang; Zhang Yufeng; Zhang Yun; Boado Ruben J; Pardridge William M
Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology.
Pharmaceutical research 2007;24(12):2309-16.
2007: Pardridge William M
Blood-brain barrier delivery of protein and non-viral gene therapeutics with molecular Trojan horses.
Journal of controlled release : official journal of the Controlled Release Society 2007;122(3):345-8.
2007: Pardridge William M
Brain drug development and brain drug targeting.
Pharmaceutical research 2007;24(9):1729-32.
2007: Pardridge William M
Drug targeting to the brain.
Pharmaceutical research 2007;24(9):1733-44.
2007: Boado Ruben J; Zhang Yufeng; Zhang Yun; Pardridge William M
Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier.
Biotechnology and bioengineering 2007;97(6):1376-86.
2007: Xia Chun-Fang; Chu Chun; Li Jianyi; Wang Yuntao; Zhang Yun; Boado Ruben J; Pardridge William M
Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes.
The journal of gene medicine 2007;9(7):605-12.
2007: Pardridge William M
shRNA and siRNA delivery to the brain.
Advanced drug delivery reviews 2007;59(2-3):141-52.
2007: Boado Ruben J; Zhang Yufeng; Zhang Yun; Xia Chun-Fang; Pardridge William M
Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation.
Bioconjugate chemistry 2007;18(2):447-55.
2007: Pardridge William M
Blood-brain barrier genomics.
Stroke; a journal of cerebral circulation 2007;38(2 Suppl):686-90.
2007: Boado Ruben J; Zhang Yufeng; Zhang Yun; Pardridge William M
Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier.
Biotechnology and bioengineering 2007;96(2):381-91.
2007: Pardridge William M
Blood-brain barrier delivery.
Drug discovery today 2007;12(1-2):54-61.
2006: Pardridge William M
Molecular Trojan horses for blood-brain barrier drug delivery.
Current opinion in pharmacology 2006;6(5):494-500.
2006: Zhang Yun; Pardridge William M
Blood-brain barrier targeting of BDNF improves motor function in rats with middle cerebral artery occlusion.
Brain research 2006;1111(1):227-9.
2006: Pardridge William M
Molecular trojan horses for blood-brain barrier drug delivery.
Discovery medicine 2006;6(34):139-43.
2006: Chu Chun; Zhang Yun; Boado Ruben J; Pardridge William M
Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation.
Pharmaceutical research 2006;23(7):1586-90.
2005: Boado Ruben J; Li Jian Yi; Chu Chun; Ogoshi Fumio; Wise Petra; Pardridge William M
Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1.
Biochimica et biophysica acta 2005;1715(2):104-10.
2005: Zhang Yun; Pardridge William M
Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1075-81.
2005: Pardridge William M
Molecular biology of the blood-brain barrier.
Molecular biotechnology 2005;30(1):57-70.
2005: Pardridge William M
Tyrosine hydroxylase replacement in experimental Parkinson's disease with transvascular gene therapy.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(1):129-38.
2005: Pardridge William M
The blood-brain barrier: bottleneck in brain drug development.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(1):3-14.
2005: Pardridge William M
The blood-brain barrier and neurotherapeutics.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(1):1-2.
2004: Boado Ruben J; Li Jian Yi; Wise Petra; Pardridge William M
Human LAT1 single nucleotide polymorphism N230K does not alter phenylalanine transport.
Molecular genetics and metabolism 2004;83(4):306-11.
2004: Suzuki Toyofumi; Zhang Yun; Zhang Yu-Feng; Schlachetzki Felix; Pardridge William M
Imaging gene expression in regional brain ischemia in vivo with a targeted [111in]-antisense radiopharmaceutical.
Molecular imaging : official journal of the Society for Molecular Imaging 2004;3(4):356-63.
2004: Suzuki Toyofumi; Wu Dafang; Schlachetzki Felix; Li Jian Yi; Boado Ruben J; Pardridge William M
Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004;45(10):1766-75.
2004: Zhu Chunni; Zhang Yun; Zhang Yu-Feng; Yi Li Jian; Boado Ruben J; Pardridge William M
Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice.
The journal of gene medicine 2004;6(8):906-12.
2004: Pardridge William M
Intravenous, non-viral RNAi gene therapy of brain cancer.
Expert opinion on biological therapy 2004;4(7):1103-13.
2004: Zhang Yun; Zhang Yu-Feng; Bryant Joshua; Charles Andrew; Boado Ruben J; Pardridge William M
Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3667-77.
2004: Pardridge William M
Log(BB), PS products and in silico models of drug brain penetration.
Drug discovery today 2004;9(9):392-3.
2004: Schlachetzki Felix; Zhang Yun; Boado Ruben J; Pardridge William M
Gene therapy of the brain: the trans-vascular approach.
Neurology 2004;62(8):1275-81.
2004: Zhang Yun; Schlachetzki Felix; Zhang Yu-Feng; Boado Ruben J; Pardridge William M
Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter.
Human gene therapy 2004;15(4):339-50.
2004: Boado Ruben J; Li Jian Yi; Pardridge William M
Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein.
Pediatric research 2004;55(4):557-60.
2004: Pardridge William M
Holy grails and in vitro blood-brain barrier models.
Drug discovery today 2004;9(6):258.
2003: Zhang Yun; Boado Ruben J; Pardridge William M
In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats.
The journal of gene medicine 2003;5(12):1039-45.
2003: Zhang Yu-feng; Boado Ruben J; Pardridge William M
Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes.
Pharmaceutical research 2003;20(11):1779-85.
2003: Schlachetzki Felix; Pardridge William M
P-glycoprotein and caveolin-1alpha in endothelium and astrocytes of primate brain.
Neuroreport 2003;14(16):2041-6.
2003: Zhang Yun; Schlachetzki Felix; Li Jian Yi; Boado Ruben J; Pardridge William M
Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer.
Molecular vision 2003;9():465-72.
2003: Shusta Eric V; Li Jian Yi; Boado Ruben J; Pardridge William M
The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature.
Neuroreport 2003;14(14):1861-5.
2003: Pardridge William M
Blood-brain barrier genomics and the use of endogenous transporters to cause drug penetration into the brain.
Current opinion in drug discovery & development 2003;6(5):683-91.
2003: Pardridge William M
Translational science: what is it and why is it so important?
Drug discovery today 2003;8(18):813-5.
2003: Lee Hwa Jeong; Pardridge William M
Monoclonal antibody radiopharmaceuticals: cationization, pegylation, radiometal chelation, pharmacokinetics, and tumor imaging.
Bioconjugate chemistry 2003;14(3):546-53.
2003: Boado Ruben J; Li Jian Yi; Tsukamoto Haruhisa; Pardridge William M
Hypoxia induces de-stabilization of the LAT1 large neutral amino acid transporter mRNA in brain capillary endothelial cells.
Journal of neurochemistry 2003;85(4):1037-42.
2003: Pardridge William M
Blood-brain barrier drug targeting: the future of brain drug development.
Molecular interventions 2003;3(2):90-105, 51.
2003: Boado Ruben J; Li Jian Yi; Pardridge William M
Site-directed mutagenesis of rabbit LAT1 at amino acids 219 and 234.
Journal of neurochemistry 2003;84(6):1322-31.
2003: Zhang Yun; Boado Ruben J; Pardridge William M
Marked enhancement in gene expression by targeting the human insulin receptor.
The journal of gene medicine 2003;5(2):157-63.
2003: Zhang Yun; Schlachetzki Felix; Pardridge William M
Global non-viral gene transfer to the primate brain following intravenous administration.
Molecular therapy : the journal of the American Society of Gene Therapy 2003;7(1):11-8.
2003: Zhang Yun; Calon Frederic; Zhu Chunni; Boado Ruben J; Pardridge William M
Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.
Human gene therapy 2003;14(1):1-12.
2003: Pardridge William M
Gene targeting in vivo with pegylated immunoliposomes.
Methods in enzymology 2003;373():507-28.
2003: Pardridge William M
Molecular biology of the blood-brain barrier.
Methods in molecular medicine 2003;89():385-99.
2002: Pardridge William M
Neurotrophins, neuroprotection and the blood-brain barrier.
Current opinion in investigational drugs (London, England : 2000) 2002;3(12):1753-7.
2002: Pardridge William M
Formulation of therapeutic synthetic polymers for drug and gene delivery.
Drug discovery today 2002;7(22):1120-1.
2002: Pardridge William M
Drug and gene delivery to the brain: the vascular route.
Neuron 2002;36(4):555-8.
2002: Li Jian Yi; Boado Ruben J; Pardridge William M
Rat blood-brain barrier genomics. II.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(11):1319-26.
2002: Lee Hwa Jeong; Zhang Yun; Pardridge William M
Blood-brain barrier disruption following the internal carotid arterial perfusion of alkyl glycerols.
Journal of drug targeting 2002;10(6):463-7.
2002: Zhu Chunni; Zhang Yun; Pardridge William M
Widespread expression of an exogenous gene in the eye after intravenous administration.
Investigative ophthalmology & visual science 2002;43(9):3075-80.
2002: Olivier Jean-Christophe; Huertas Ramon; Lee Hwa Jeong; Calon Frederic; Pardridge William M
Synthesis of pegylated immunonanoparticles.
Pharmaceutical research 2002;19(8):1137-43.
2002: Shusta Eric V; Zhu Chunni; Boado Ruben J; Pardridge William M
Subtractive expression cloning reveals high expression of CD46 at the blood-brain barrier.
Journal of neuropathology and experimental neurology 2002;61(7):597-604.
2002: Lee Hwa Jeong; Boado Ruben J; Braasch Dwaine A; Corey David R; Pardridge William M
Imaging gene expression in the brain in vivo in a transgenic mouse model of Huntington's disease with an antisense radiopharmaceutical and drug-targeting technology.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2002;43(7):948-56.
2002: Zhang Yun; Zhu Chunni; Pardridge William M
Antisense gene therapy of brain cancer with an artificial virus gene delivery system.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(1):67-72.
2002: Wu Dafang; Song Bi-Wei; Vinters Harry V; Pardridge William M
Pharmacokinetics and brain uptake of biotinylated basic fibroblast growth factor conjugated to a blood-brain barrier drug delivery system.
Journal of drug targeting 2002;10(3):239-45.
2002: Song Bi-Wei; Vinters Harry V; Wu Dafang; Pardridge William M
Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector.
The Journal of pharmacology and experimental therapeutics 2002;301(2):605-10.
2002: Schlachetzki Felix; Zhu Chunni; Pardridge William M
Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier.
Journal of neurochemistry 2002;81(1):203-6.
2002: Zhang Yun; Jeong Lee Hwa; Boado Ruben J; Pardridge William M
Receptor-mediated delivery of an antisense gene to human brain cancer cells.
The journal of gene medicine 2002;4(2):183-94.
2002: Shusta Eric V; Boado Ruben J; Mathern Gary W; Pardridge William M
Vascular genomics of the human brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(3):245-52.
2002: Pardridge William M
Drug and gene targeting to the brain with molecular Trojan horses.
Nature reviews. Drug discovery 2002;1(2):131-9.
2002: Boado Ruben J; Pardridge William M
Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element.
Journal of neurochemistry 2002;80(3):552-4.
2002: Pardridge William M
William Pardridge discusses the lack of BBB research. Interview by Rebecca N. Lawrence.
Drug discovery today 2002;7(4):223-6.
2002: Lee Hwa Jeong; Zhang Yun; Zhu Chunni; Duff Karen; Pardridge William M
Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(2):223-31.
2002: Shusta Eric V; Boado Ruben J; Pardridge William M
Vascular proteomics and subtractive antibody expression cloning.
Molecular & cellular proteomics : MCP 2002;1(1):75-82.
2002: Pardridge William M
Why is the global CNS pharmaceutical market so under-penetrated?
Drug discovery today 2002;7(1):5-7.
2002: Pardridge William M
Targeting neurotherapeutic agents through the blood-brain barrier.
Archives of neurology 2002;59(1):35-40.
2002: Pardridge William M
Blood-brain barrier drug targeting enables neuroprotection in brain ischemia following delayed intravenous administration of neurotrophins.
Advances in experimental medicine and biology 2002;513():397-430.
2001: Lee H J; Pardridge W M
Pharmacokinetics and delivery of tat and tat-protein conjugates to tissues in vivo.
Bioconjugate chemistry 2001;12(6):995-9.
2001: Li J Y; Boado R J; Pardridge W M
Differential kinetics of transport of 2',3'-dideoxyinosine and adenosine via concentrative Na+ nucleoside transporter CNT2 cloned from rat blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2001;299(2):735-40.
2001: Shi N; Zhang Y; Zhu C; Boado R J; Pardridge W M
Brain-specific expression of an exogenous gene after i.v. administration.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12754-9.
2001: Shi N; Boado R J; Pardridge W M
Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes.
Pharmaceutical research 2001;18(8):1091-5.
2001: Li J Y; Boado R J; Pardridge W M
Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(8):929-36.
2001: Zhang Y; Pardridge W M
Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system.
Stroke; a journal of cerebral circulation 2001;32(6):1378-84.
2001: Bickel U; Yoshikawa T; Pardridge W M
Delivery of peptides and proteins through the blood-brain barrier.
Advanced drug delivery reviews 2001;46(1-3):247-79.
2001: Zhang Y; Pardridge W M
Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.
Journal of neuroimmunology 2001;114(1-2):168-72.
2001: Zhang Y; Pardridge W M
Rapid transferrin efflux from brain to blood across the blood-brain barrier.
Journal of neurochemistry 2001;76(5):1597-600.
2001: Zhang Y; Pardridge W M
Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin.
Brain research 2001;889(1-2):49-56.
2001: Li J Y; Boado R J; Pardridge W M
Blood-brain barrier genomics.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2001;21(1):61-8.
2000: Shi N; Boado R J; Pardridge W M
Antisense imaging of gene expression in the brain in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(26):14709-14.
2000: Boado R J; Kazantsev A; Apostol B L; Thompson L M; Pardridge W M
Antisense-mediated down-regulation of the human huntingtin gene.
The Journal of pharmacology and experimental therapeutics 2000;295(1):239-43.
2000: Boado R J; Li J Y; Pardridge W M
Selective Lutheran glycoprotein gene expression at the blood-brain barrier in normal brain and in human brain tumors.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(7):1096-102.
2000: Shi N; Pardridge W M
Noninvasive gene targeting to the brain.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7567-72.
2000: Kurihara A; Pardridge W M
Abeta(1-40) peptide radiopharmaceuticals for brain amyloid imaging: (111)In chelation, conjugation to poly(ethylene glycol)-biotin linkers, and autoradiography with Alzheimer's disease brain sections.
Bioconjugate chemistry 2000;11(3):380-6.
2000: Golden P L; Pardridge W M
Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain.
Cellular and molecular neurobiology 2000;20(2):165-81.
2000: Coloma M J; Lee H J; Kurihara A; Landaw E M; Boado R J; Morrison S L; Pardridge W M
Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor.
Pharmaceutical research 2000;17(3):266-74.
2000: Lee H J; Engelhardt B; Lesley J; Bickel U; Pardridge W M
Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse.
The Journal of pharmacology and experimental therapeutics 2000;292(3):1048-52.
2000: Jeong Lee H; Pardridge W M
Drug targeting to the brain using avidin-biotin technology in the mouse; (blood-brain barrier, monoclonal antibody, transferrin receptor, Alzheimer's disease).
Journal of drug targeting 2000;8(6):413-24.
2000: Boado R J; Ji A; Pardridge W M
Cloning and expression in Pichia pastoris of a genetically engineered single chain antibody against the rat transferrin receptor.
Journal of drug targeting 2000;8(6):403-12.
1999: Kurihara A; Pardridge W M
Imaging brain tumors by targeting peptide radiopharmaceuticals through the blood-brain barrier.
Cancer research 1999;59(24):6159-63.
1999: Boado R J; Li J Y; Nagaya M; Zhang C; Pardridge W M
Selective expression of the large neutral amino acid transporter at the blood-brain barrier.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):12079-84.
1999: Penichet M L; Kang Y S; Pardridge W M; Morrison S L; Shin S U
An antibody-avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4421-6.
1999: Li J Y; Sugimura K; Boado R J; Lee H J; Zhang C; Duebel S; Pardridge W M
Genetically engineered brain drug delivery vectors: cloning, expression and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein.
Protein engineering 1999;12(9):787-96.
1999: Kurihara A; Deguchi Y; Pardridge W M
Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors.
Bioconjugate chemistry 1999;10(3):502-11.
1999: Wu D; Pardridge W M
Blood-brain barrier transport of reduced folic acid.
Pharmaceutical research 1999;16(3):415-9.
1999: Golden P L; Pardridge W M
P-Glycoprotein on astrocyte foot processes of unfixed isolated human brain capillaries.
Brain research 1999;819(1-2):143-6.
1999: Deguchi Y; Kurihara A; Pardridge W M
Retention of biologic activity of human epidermal growth factor following conjugation to a blood-brain barrier drug delivery vector via an extended poly(ethylene glycol) linker.
Bioconjugate chemistry 1999;10(1):32-7.
1999: Boado R J; Pardridge W M
Amplification of gene expression using both 5'- and 3'-untranslated regions of GLUT1 glucose transporter mRNA.
Brain research. Molecular brain research 1999;63(2):371-4.
1999: Wu D; Pardridge W M
Neuroprotection with noninvasive neurotrophin delivery to the brain.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):254-9.
1998: Pardridge W M; Yang J; Diagne A
Chloroquine inhibits HIV-1 replication in human peripheral blood lymphocytes.
Immunology letters 1998;64(1):45-7.
1998: Boado R J; Tsukamoto H; Pardridge W M
Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS.
Journal of pharmaceutical sciences 1998;87(11):1308-15.
1998: Boado R J; Golden P L; Levin N; Pardridge W M
Up-regulation of blood-brain barrier short-form leptin receptor gene products in rats fed a high fat diet.
Journal of neurochemistry 1998;71(4):1761-4.
1998: Wu D; Pardridge W M
Pharmacokinetics and blood-brain barrier transport of an anti-transferrin receptor monoclonal antibody (OX26) in rats after chronic treatment with the antibody.
Drug metabolism and disposition: the biological fate of chemicals 1998;26(9):937-9.
1998: Boado R J; Pardridge W M
Ten nucleotide cis element in the 3'-untranslated region of the GLUT1 glucose transporter mRNA increases gene expression via mRNA stabilization.
Brain research. Molecular brain research 1998;59(1):109-13.
1998: Tsukamoto H; Hamada Y; Wu D; Boado R J; Pardridge W M
GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues.
Brain research. Molecular brain research 1998;58(1-2):170-7.
1998: Pardridge W M; Buciak J; Yang J; Wu D
Enhanced endocytosis in cultured human breast carcinoma cells and in vivo biodistribution in rats of a humanized monoclonal antibody after cationization of the protein.
The Journal of pharmacology and experimental therapeutics 1998;286(1):548-54.
1998: Pardridge W M
CNS drug design based on principles of blood-brain barrier transport.
Journal of neurochemistry 1998;70(5):1781-92.
1998: Wu D; Clement J G; Pardridge W M
Low blood-brain barrier permeability to azidothymidine (AZT), 3TC, and thymidine in the rat.
Brain research 1998;791(1-2):313-6.
1998: Pardridge W M; Wu D; Sakane T
Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration.
Pharmaceutical research 1998;15(4):576-82.
1997: Wu D; Yang J; Pardridge W M
Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor.
The Journal of clinical investigation 1997;100(7):1804-12.
1997: Huwyler J; Yang J; Pardridge W M
Receptor mediated delivery of daunomycin using immunoliposomes: pharmacokinetics and tissue distribution in the rat.
The Journal of pharmacology and experimental therapeutics 1997;282(3):1541-6.
1997: Sakane T; Pardridge W M
Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity.
Pharmaceutical research 1997;14(8):1085-91.
1997: Pardridge W M
Drug delivery to the brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(7):713-31.
1997: Wu D; Kang Y S; Bickel U; Pardridge W M
Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(6):768-71.
1997: Tsukamoto H; Boado R J; Pardridge W M
Site-directed deletion of a 10-nucleotide domain of the 3'-untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain tumors and induction of reporter gene expression.
Journal of neurochemistry 1997;68(6):2587-92.
1997: Shin S U; Wu D; Ramanathan R; Pardridge W M; Morrison S L
Functional and pharmacokinetic properties of antibody-avidin fusion proteins.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(10):4797-804.
1997: Pardridge W M; Golden P L; Kang Y S; Bickel U
Brain microvascular and astrocyte localization of P-glycoprotein.
Journal of neurochemistry 1997;68(3):1278-85.
1997: Golden P L; Maccagnan T J; Pardridge W M
Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels.
The Journal of clinical investigation 1997;99(1):14-8.
1996: Huwyler J; Wu D; Pardridge W M
Brain drug delivery of small molecules using immunoliposomes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14164-9.
1996: Wu D; Pardridge W M
Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system.
The Journal of pharmacology and experimental therapeutics 1996;279(1):77-83.
1996: Boado R J; Tsukamoto H; Pardridge W M
Evidence for translational control elements within the 5'-untranslated region of GLUT1 glucose transporter mRNA.
Journal of neurochemistry 1996;67(4):1335-43.
1996: Tsukamoto H; Boado R J; Pardridge W M
Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA.
The Journal of clinical investigation 1996;97(12):2823-32.
1996: Dwyer K J; Boado R J; Pardridge W M
Cis-element/cytoplasmic protein interaction within the 3'-untranslated region of the GLUT1 glucose transporter mRNA.
Journal of neurochemistry 1996;66(2):449-58.
1996: Kumagai A K; Vinores S A; Pardridge W M
Pathological upregulation of inner blood-retinal barrier Glut1 glucose transporter expression in diabetes mellitus.
Brain research 1996;706(2):313-7.
1996: Pardridge W M; Kang Y S; Diagne A; Zack J A
Cationized hyperimmune immunoglobulins: pharmacokinetics, toxicity evaluation and treatment of human immunodeficiency virus-infected human-peripheral blood lymphocytes-severe combined immune deficiency mice.
The Journal of pharmacology and experimental therapeutics 1996;276(1):246-52.
1996: Wu D; Boado R J; Pardridge W M
Pharmacokinetics and blood-brain barrier transport of [3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system.
The Journal of pharmacology and experimental therapeutics 1996;276(1):206-11.
1995: Kumagai A K; Kang Y S; Boado R J; Pardridge W M
Upregulation of blood-brain barrier GLUT1 glucose transporter protein and mRNA in experimental chronic hypoglycemia.
Diabetes 1995;44(12):1399-404.
1995: Boado R J; Kang Y S; Wu D; Pardridge W M
Rapid plasma clearance and metabolism in vivo of a phosphorothioate oligodeoxynucleotide with a single, internal phosphodiester bond.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(11):1297-300.
1995: Cornford E M; Hyman S; Black K L; Cornford M E; Vinters H V; Pardridge W M
High expression of the Glut1 glucose transporter in human brain hemangioblastoma endothelium.
Journal of neuropathology and experimental neurology 1995;54(6):842-51.
1995: Saito Y; Buciak J; Yang J; Pardridge W M
Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10227-31.
1995: Pardridge W M; Kang Y S; Yang J; Buciak J L
Enhanced cellular uptake and in vivo biodistribution of a monoclonal antibody following cationization.
Journal of pharmaceutical sciences 1995;84(8):943-8.
1995: Pardridge W M; Boado R J; Kang Y S
Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5592-6.
1995: Pardridge W M; Kang Y S; Buciak J L; Yang J
Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate.
Pharmaceutical research 1995;12(6):807-16.
1995: Skarlatos S; Yoshikawa T; Pardridge W M
Transport of [125I]transferrin through the rat blood-brain barrier.
Brain research 1995;683(2):164-71.
1995: Shin S U; Friden P; Moran M; Olson T; Kang Y S; Pardridge W M; Morrison S L
Transferrin-antibody fusion proteins are effective in brain targeting.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2820-4.
1995: Bickel U; Kang Y S; Pardridge W M
In vivo cleavability of a disulfide-based chimeric opioid peptide in rat brain.
Bioconjugate chemistry 1995;6(2):211-8.
1995: Kang Y S; Boado R J; Pardridge W M
Pharmacokinetics and organ clearance of a 3'-biotinylated, internally [32P]-labeled phosphodiester oligodeoxynucleotide coupled to a neutral avidin/monoclonal antibody conjugate.
Drug metabolism and disposition: the biological fate of chemicals 1995;23(1):55-9.
1995: Bickel U; Pardridge W M
Vector-mediated delivery of opioid peptides to the brain.
NIDA research monograph 1995;154():28-46.
1995: Skarlatos S; Pardridge W M
Targeting of an anti-CR3 (CD11b/CD18) monoclonal antibody to spleen but not brain, in vivo in mice.
Journal of drug targeting 1995;3(1):9-14.
1995: Kang Y S; Saito Y; Pardridge W M
Pharmacokinetics of [3H]biotin bound to different avidin analogues.
Journal of drug targeting 1995;3(2):159-65.
1994: Black K L; Baba T; Pardridge W M
Enzymatic barrier protects brain capillaries from leukotriene C4.
Journal of neurosurgery 1994;81(5):745-51.
1994: Bickel U; Kang Y S; Yoshikawa T; Pardridge W M
In vivo demonstration of subcellular localization of anti-transferrin receptor monoclonal antibody-colloidal gold conjugate in brain capillary endothelium.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(11):1493-7.
1994: Boado R J; Pardridge W M
Differential expression of alpha-actin mRNA and immunoreactive protein in brain microvascular pericytes and smooth muscle cells.
Journal of neuroscience research 1994;39(4):430-5.
1994: Boado R J; Black K L; Pardridge W M
Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors.
Brain research. Molecular brain research 1994;27(1):51-7.
1994: Pardridge W M; Bickel U; Buciak J; Yang J; Diagne A; Aepinus C
Cationization of a monoclonal antibody to the human immunodeficiency virus REV protein enhances cellular uptake but does not impair antigen binding of the antibody.
Immunology letters 1994;42(3):191-5.
1994: Pardridge W M; Buciak J; Yang J; Diagne A
Treatment of human immunodeficiency virus-infected lymphocytes with cationized human immunoglobulins.
The Journal of infectious diseases 1994;170(3):563-9.
1994: Boado R J; Pardridge W M
Complete inactivation of target mRNA by biotinylated antisense oligodeoxynucleotide-avidin conjugates.
Bioconjugate chemistry 1994;5(5):406-10.
1994: Kang Y S; Pardridge W M
Brain delivery of biotin bound to a conjugate of neutral avidin and cationized human albumin.
Pharmaceutical research 1994;11(9):1257-64.
1994: Samii A; Bickel U; Stroth U; Pardridge W M
Blood-brain barrier transport of neuropeptides: analysis with a metabolically stable dermorphin analogue.
The American journal of physiology 1994;267(1 Pt 1):E124-31.
1994: Kumagai A K; Dwyer K J; Pardridge W M
Differential glycosylation of the GLUT1 glucose transporter in brain capillaries and choroid plexus.
Biochimica et biophysica acta 1994;1193(1):24-30.
1994: Boado R J; Pardridge W M
Measurement of blood-brain barrier GLUT1 glucose transporter and actin mRNA by a quantitative polymerase chain reaction assay.
Journal of neurochemistry 1994;62(6):2085-90.
1994: Pardridge W M; Kang Y S; Buciak J L
Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery.
Pharmaceutical research 1994;11(5):738-46.
1994: Kang Y S; Pardridge W M
Use of neutral avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate.
The Journal of pharmacology and experimental therapeutics 1994;269(1):344-50.
1994: Bickel U; Lee V M; Trojanowski J Q; Pardridge W M
Development and in vitro characterization of a cationized monoclonal antibody against beta A4 protein: a potential probe for Alzheimer's disease.
Bioconjugate chemistry 1994;5(2):119-25.
1994: Boado R J; Wang L; Pardridge W M
Enhanced expression of the blood-brain barrier GLUT1 glucose transporter gene by brain-derived factors.
Brain research. Molecular brain research 1994;22(1-4):259-67.
1994: Bickel U; Yamada S; Pardridge W M
Synthesis and bioactivity of monobiotinylated DALDA: a mu-specific opioid peptide designed for targeted brain delivery.
The Journal of pharmacology and experimental therapeutics 1994;268(2):791-6.
1994: Pardridge W M; Yoshikawa T; Kang Y S; Miller L P
Blood-brain barrier transport and brain metabolism of adenosine and adenosine analogs.
The Journal of pharmacology and experimental therapeutics 1994;268(1):14-8.
1994: Pardridge W M; Bickel U; Buciak J; Yang J; Diagne A
Enhanced endocytosis and anti-human immunodeficiency virus type 1 activity of anti-rev antibodies after cationization.
The Journal of infectious diseases 1994;169(1):55-61.
1994: Kang Y S; Bickel U; Pardridge W M
Pharmacokinetics and saturable blood-brain barrier transport of biotin bound to a conjugate of avidin and a monoclonal antibody to the transferrin receptor.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(1):99-105.
1993: Pardridge W M; Buciak J L; Kang Y S; Boado R J
Protamine-mediated transport of albumin into brain and other organs of the rat. Binding and endocytosis of protamine-albumin complex by microvascular endothelium.
The Journal of clinical investigation 1993;92(5):2224-9.
1993: Cornford E M; Hyman S; Pardridge W M
An electron microscopic immunogold analysis of developmental up-regulation of the blood-brain barrier GLUT1 glucose transporter.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1993;13(5):841-54.
1993: Lutz A J; Pardridge W M
Insulin therapy normalizes GLUT1 glucose transporter mRNA but not immunoreactive transporter protein in streptozocin-diabetic rats.
Metabolism: clinical and experimental 1993;42(8):939-44.
1993: Pardridge W M
Transport of insulin-related peptides and glucose across the blood-brain barrier.
Annals of the New York Academy of Sciences 1993;692():126-37.
1993: Boado R J; Pardridge W M
Glucose deprivation causes posttranscriptional enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization.
Journal of neurochemistry 1993;60(6):2290-6.
1993: Bickel U; Yoshikawa T; Landaw E M; Faull K F; Pardridge W M
Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2618-22.
1993: Dwyer K J; Pardridge W M
Developmental modulation of blood-brain barrier and choroid plexus GLUT1 glucose transporter messenger ribonucleic acid and immunoreactive protein in rabbits.
Endocrinology 1993;132(2):558-65.
1992: Yoshikawa T; Pardridge W M
Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor.
The Journal of pharmacology and experimental therapeutics 1992;263(2):897-903.
1992: Boado R J; Pardridge W M
Complete protection of antisense oligonucleotides against serum nuclease degradation by an avidin-biotin system.
Bioconjugate chemistry 1992;3(6):519-23.
1992: Boado R J; Pardridge W M; Vinters H V; Black K L
Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9044-8.
1992: Farrell C R; Boado R J; Pardridge W M
Enhanced GLUT1 glucose transporter and cytoskeleton gene expression in cultured bovine brain capillary endothelial cells after treatment with phorbol esters and serum.
Brain research. Molecular brain research 1992;15(3-4):221-6.
1992: Pardridge W M
Recent developments in peptide drug delivery to the brain.
Pharmacology & toxicology 1992;71(1):3-10.
1992: Pardridge W M; Buciak J L; Yoshikawa T
Transport of recombinant CD4 through the rat blood-brain barrier in vivo.
The Journal of pharmacology and experimental therapeutics 1992;261(3):1175-80.
1992: Cramer S C; Pardridge W M; Hirayama B A; Wright E M
Colocalization of GLUT2 glucose transporter, sodium/glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocytochemistry.
Diabetes 1992;41(6):766-70.
1992: Farrell C L; Yang J; Pardridge W M
GLUT-1 glucose transporter is present within apical and basolateral membranes of brain epithelial interfaces and in microvascular endothelia with and without tight junctions.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1992;40(2):193-9.
1992: Cornford E M; Young D; Paxton J W; Finlay G J; Wilson W R; Pardridge W M
Melphalan penetration of the blood-brain barrier via the neutral amino acid transporter in tumor-bearing brain.
Cancer research 1992;52(1):138-43.
1992: Pardridge W M
Opioid peptide drug development: transport of opioid chimeric peptides through the blood-brain barrier.
NIDA research monograph 1992;120():153-68.
1991: Pardridge W M
Advances in cell biology of blood-brain barrier transport.
Seminars in cell biology 1991;2(6):419-26.
1991: Pardridge W M; Buciak J L; Friden P M
Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo.
The Journal of pharmacology and experimental therapeutics 1991;259(1):66-70.
1991: Pardridge W M; Boado R J
Enhanced cellular uptake of biotinylated antisense oligonucleotide or peptide mediated by avidin, a cationic protein.
FEBS letters 1991;288(1-2):30-2.
1991: Triguero D; Buciak J L; Pardridge W M
Cationization of immunoglobulin G results in enhanced organ uptake of the protein after intravenous administration in rats and primate.
The Journal of pharmacology and experimental therapeutics 1991;258(1):186-92.
1991: Farrell C L; Pardridge W M
Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(13):5779-83.
1991: Farrell C L; Pardridge W M
Ultrastructural localization of blood-brain barrier-specific antibodies using immunogold-silver enhancement techniques.
Journal of neuroscience methods 1991;37(2):103-10.
1991: Pardridge W M; Buciak J L; Yang J; Miller B L; Vinters H V
Measurement of amyloid peptide precursor of Alzheimer disease in human blood by double antibody immunoradiometric assay.
Alzheimer disease and associated disorders 1991;5(1):12-24.
1990: Boado R J; Pardridge W M
Molecular cloning of the bovine blood-brain barrier glucose transporter cDNA and demonstration of phylogenetic conservation of the 5'-untranslated region.
Molecular and cellular neurosciences 1990;1(3):224-32.
1990: Pardridge W M; Triguero D; Buciak J; Yang J
Evaluation of cationized rat albumin as a potential blood-brain barrier drug transport vector.
The Journal of pharmacology and experimental therapeutics 1990;255(2):893-9.
1990: Pardridge W M; Boado R J; Farrell C R
Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization.
The Journal of biological chemistry 1990;265(29):18035-40.
1990: Pardridge W M; Triguero D; Farrell C R
Downregulation of blood-brain barrier glucose transporter in experimental diabetes.
Diabetes 1990;39(9):1040-4.
1990: Pardridge W M; Yang J; Buciak J L; Boado R J
Differential expression of 53- and 45-kDa brain capillary-specific proteins by brain capillary endothelium and choroid plexus in vivo and by brain capillary endothelium in tissue culture.
Molecular and cellular neurosciences 1990;1(1):20-8.
1990: Vinters H V; Nishimura G S; Secor D L; Pardridge W M
Immunoreactive A4 and gamma-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease.
The American journal of pathology 1990;137(2):233-40.
1990: Vinters H V; Secor D L; Pardridge W M; Gray F
Immunohistochemical study of cerebral amyloid angiopathy. III. Widespread Alzheimer A4 peptide in cerebral microvessel walls colocalizes with gamma trace in patients with leukoencephalopathy.
Annals of neurology 1990;28(1):34-42.
1990: Triguero D; Buciak J; Pardridge W M
Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins.
Journal of neurochemistry 1990;54(6):1882-8.
1990: Wall K M; Pardridge W M
Decreases in brain protein synthesis elicited by moderate increases in plasma phenylalanine.
Biochemical and biophysical research communications 1990;168(3):1177-83.
1990: Pardridge W M; Triguero D; Yang J; Cancilla P A
Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1990;253(2):884-91.
1990: Lupo M A; Cefalu W T; Pardridge W M
Kinetics of lactate transport into rat liver in vivo.
Metabolism: clinical and experimental 1990;39(4):374-7.
1990: Pardridge W M; Fierer G
Transport of tryptophan into brain from the circulating, albumin-bound pool in rats and in rabbits.
Journal of neurochemistry 1990;54(3):971-6.
1990: Hargreaves-Wall K M; Buciak J L; Pardridge W M
Measurement of free intracellular and transfer RNA amino acid specific activity and protein synthesis in rat brain in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1990;10(2):162-9.
1990: Pardridge W M; Triguero D; Buciak J L
Beta-endorphin chimeric peptides: transport through the blood-brain barrier in vivo and cleavage of disulfide linkage by brain.
Endocrinology 1990;126(2):977-84.
1990: Boado R J; Pardridge W M
The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier.
Biochemical and biophysical research communications 1990;166(1):174-9.
1990: Ellison S A; Pardridge W M
Reduction of testosterone availability to 5 alpha-reductase by human sex hormone-binding globulin in the rat ventral prostate gland in vivo.
The Prostate 1990;17(4):281-91.
1989: Pardridge W M; Triguero D; Buciak J
Transport of histone through the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1989;251(3):821-6.
1989: Choi T B; Boado R J; Pardridge W M
Blood-brain barrier glucose transporter mRNA is increased in experimental diabetes mellitus.
Biochemical and biophysical research communications 1989;164(1):375-80.
1989: Pardridge W M; Nowlin D M; Choi T B; Yang J; Calaycay J; Shively J E
Brain capillary 46,000 dalton protein is cytoplasmic actin and is localized to endothelial plasma membrane.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1989;9(5):675-80.
1989: Pardridge W M; Nowlin D M; Calaycay J; Shively J E
Predominant low-molecular-weight proteins in isolated brain capillaries are histones.
Journal of neurochemistry 1989;53(4):1014-8.
1989: Pardridge W M
Strategies for drug delivery through the blood-brain barrier.
Neurobiology of aging 1989;10(5):636-7; discussion 648-50.
1989: Pardridge W M; Yang J; Buciak J; Tourtellotte W W
Human brain microvascular DR-antigen.
Journal of neuroscience research 1989;23(3):337-41.
1989: Triguero D; Buciak J B; Yang J; Pardridge W M
Blood-brain barrier transport of cationized immunoglobulin G: enhanced delivery compared to native protein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4761-5.
1988: Hargreaves K M; Pardridge W M
Neutral amino acid transport at the human blood-brain barrier.
The Journal of biological chemistry 1988;263(36):19392-7.
1988: Terasaki T; Nowlin D M; Pardridge W M
Differential binding of testosterone and estradiol to isoforms of sex hormone-binding globulin: selective alteration of estradiol binding in cirrhosis.
The Journal of clinical endocrinology and metabolism 1988;67(4):639-43.
1988: Vinters H V; Pardridge W M; Secor D L; Ishii N
Immunohistochemical study of cerebral amyloid angiopathy. II. Enhancement of immunostaining using formic acid pretreatment of tissue sections.
The American journal of pathology 1988;133(1):150-62.
1988: Terasaki T; Pardridge W M
Restricted transport of 3'-azido-3'-deoxythymidine and dideoxynucleosides through the blood-brain barrier.
The Journal of infectious diseases 1988;158(3):630-2.
1988: Sakiyama R; Pardridge W M; Musto N A
Influx of testosterone-binding globulin (TeBG) and TeBG-bound sex steroid hormones into rat testis and prostate.
The Journal of clinical endocrinology and metabolism 1988;67(1):98-103.
1988: Terasaki T; Pardridge W M
Differential binding of thyroxine and triiodothyronine to acidic isoforms of thyroid hormone binding globulin in human serum.
Biochemistry 1988;27(10):3624-8.
1988: Pardridge W M; Eisenberg J; Fierer G; Musto N A
Developmental changes in brain and serum binding of testosterone and in brain capillary uptake of testosterone-binding serum proteins in the rabbit.
Brain research 1988;466(2):245-53.
1988: Duffy K R; Pardridge W M; Rosenfeld R G
Human blood-brain barrier insulin-like growth factor receptor.
Metabolism: clinical and experimental 1988;37(2):136-40.
1988: Pardridge W M
Does the brain's gatekeeper falter in aging?
Neurobiology of aging 1988;9(1):44-6.
1988: Chaudhuri G; Steingold K A; Pardridge W M; Judd H L
TeBG- and CBG-bound steroid hormones in rabbits are available for influx into uterus in vivo.
The American journal of physiology 1988;254(1 Pt 1):E79-83.
1988: Pardridge W M
New directions in blood-brain barrier research. Studies with isolated human brain capillaries.
Annals of the New York Academy of Sciences 1988;529():50-60.
1988: Pardridge W M
Selective delivery of sex steroid hormones to tissues in vivo by albumin and by sex hormone-binding globulin.
Annals of the New York Academy of Sciences 1988;538():173-92.
1987: Pardridge W M; Vinters H V; Yang J; Eisenberg J; Choi T B; Tourtellotte W W; Huebner V; Shively J E
Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels.
Journal of neurochemistry 1987;49(5):1394-401.
1987: Kumagai A K; Eisenberg J B; Pardridge W M
Absorptive-mediated endocytosis of cationized albumin and a beta-endorphin-cationized albumin chimeric peptide by isolated brain capillaries. Model system of blood-brain barrier transport.
The Journal of biological chemistry 1987;262(31):15214-9.
1987: Duffy K R; Pardridge W M
Blood-brain barrier transcytosis of insulin in developing rabbits.
Brain research 1987;420(1):32-8.
1987: Pardridge W M; Yang J; Eisenberg J; Tourtellotte W W
Isolation of intact capillaries and capillary plasma membranes from frozen human brain.
Journal of neuroscience research 1987;18(2):352-7.
1986: Pardridge W M; Eisenberg J; Fierer G; Kuhn R W
CBG does not restrict blood-brain barrier corticosterone transport in rabbits.
The American journal of physiology 1986;251(2 Pt 1):E204-8.

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