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Hans Parge

Research Profile

Chemicals & Drugs

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X Ray Crystallography

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Genes & Molecular Sequences

Amino Acid Sequences

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Viral Drug Resistance

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Publications

TOP 3
Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Tanya Jewell; Leena Patel; Sarah Ludlum; Matthew Drowns; Sadayappan V Rahavendran; Heather Skor; Robert Hunter; Stephanie T Shi; Koleen J Herlihy; Hans E Parge; Michael Hickey; Xiu Yu; Fannie Chau; Jim Nonomiya; Cristina Lewis
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Stephanie T Shi; Koleen J Herlihy; Joanne P Graham; Shella A Fuhrman; Chau Doan; Hans E Parge; Michael Hickey; Jingjin Gao; Xiu Yu; Fannie Chau; Javier Gonzalez; Hui Li; Cristina Lewis; Amy K Patick; Rohit Duggal
In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Allen Borchardt; Peter S Dragovich; Tanya Jewell; Thomas J Prins; Ru Zhou; Julie Blazel; Hans E Parge; Robert Love; Michael Hickey; Chau Doan; Stephanie Shi; Rohit Duggal; Cristina Lewis; Shella A Fuhrman
Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.

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All Publications

2009: Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Tanya Jewell; Leena Patel; Sarah Ludlum; Matthew Drowns; Sadayappan V Rahavendran; Heather Skor; Robert Hunter; Stephanie T Shi; Koleen J Herlihy; Hans E Parge; Michael Hickey; Xiu Yu; Fannie Chau; Jim Nonomiya; Cristina Lewis
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Journal of medicinal chemistry 2009;52(5):1255-8.
2008: Stephanie T Shi; Koleen J Herlihy; Joanne P Graham; Shella A Fuhrman; Chau Doan; Hans E Parge; Michael Hickey; Jingjin Gao; Xiu Yu; Fannie Chau; Javier Gonzalez; Hui Li; Cristina Lewis; Amy K Patick; Rohit Duggal
In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Antimicrobial agents and chemotherapy 2008;52(2):675-83.
2006: Hui Li; John Tatlock; Angelica Linton; Javier Gonzalez; Allen Borchardt; Peter S Dragovich; Tanya Jewell; Thomas J Prins; Ru Zhou; Julie Blazel; Hans E Parge; Robert Love; Michael Hickey; Chau Doan; Stephanie Shi; Rohit Duggal; Cristina Lewis; Shella A Fuhrman
Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(18):4834-8.
2004: Robert A Love; Karen A Maegley; Xiu Yu; Rose Ann Ferre; Laura K Lingardo; Wade Diehl; Hans E Parge; Peter S Dragovich; Shella A Fuhrman
The crystal structure of the RNA-dependent RNA polymerase from human rhinovirus: a dual function target for common cold antiviral therapy.
Structure (London, England : 1993) 2004;12(8):1533-44.
2003: Robert A Love; Hans E Parge; Xiu Yu; Michael J Hickey; Wade Diehl; Jingjin Gao; Hilary Wriggers; Anne Ekker; Liann Wang; James A Thomson; Peter S Dragovich; Shella A Fuhrman
Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme.
Journal of virology 2003;77(13):7575-81.
1998: Robert A Love; Hans E Parge; J A Wickersham; Z Hostomsky; N Habuka; E W Moomaw; T Adachi; S Margosiak; E Dagostino; Z Hostomska
The conformation of hepatitis C virus NS3 proteinase with and without NS4A: a structural basis for the activation of the enzyme by its cofactor.
Clinical and diagnostic virology 1998;10(2-3):151-6.