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Robert Parise

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Jianxia Guo; Robert A Parise; Elizabeth R Sharlow; Qiming Jane Wang; Peter Wipf; Jan H Beumer; Karla Bravo-Altamirano; Dana M Clausen; Merrill J Egorin; Julie L Eiseman
In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.
Robert A Parise; Bean N Anyang; Joseph M Covey; Merrill J Egorin; Julie L Eiseman; Jan H Beumer
Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines.
Jan H Beumer; David Z D'Argenio; Beatriz Kanterewicz; Robert A Parise; Martin Petkovich; Pamela A Hershberger
A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS assay.

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All Publications

2013: Jianxia Guo; Robert A Parise; Elizabeth R Sharlow; Qiming Jane Wang; Peter Wipf; Jan H Beumer; Karla Bravo-Altamirano; Dana M Clausen; Merrill J Egorin; Julie L Eiseman
In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts.
Cancer chemotherapy and pharmacology 2013;71(2):331-44.
2013: Robert A Parise; Bean N Anyang; Joseph M Covey; Merrill J Egorin; Julie L Eiseman; Jan H Beumer
Formation of active products of benzaldehyde dimethane sulfonate (NSC 281612, DMS612) in human blood and plasma and their activity against renal cell carcinoma lines.
Cancer chemotherapy and pharmacology 2013;71(1):73-83.
2012: Jan H Beumer; David Z D'Argenio; Beatriz Kanterewicz; Robert A Parise; Martin Petkovich; Pamela A Hershberger
A local effect of CYP24 inhibition on lung tumor xenograft exposure to 1,25-dihydroxyvitamin D(3) is revealed using a novel LC-MS/MS assay.
Steroids 2012;77(5):477-83.
2011: Jan H Beumer; Julie L Eiseman; Judith A Gilbert; Julianne L Holleran; Archibong E Yellow-Duke; Dana M Clausen; David Z D'Argenio; Matthew M Ames; Pamela A Hershberger; Robert A Parise; Lihua Bai; Joseph M Covey; Merrill J Egorin
Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.
Cancer chemotherapy and pharmacology 2011;67(2):421-30.
2010: Dana M Clausen; Jianxia Guo; Robert A Parise; Jan H Beumer; Merrill J Egorin; John Lazo; Edward V Prochownik; Julie L Eiseman
In vitro cytotoxicity and in vivo efficacy, pharmacokinetics, and metabolism of 10074-G5, a novel small-molecule inhibitor of c-Myc/Max dimerization.
The Journal of pharmacology and experimental therapeutics 2010;335(3):715-27.
2010: Julianne L Holleran; Robert A Parise; Archibong E Yellow-Duke; Merrill J Egorin; Julie L Eiseman; Joseph M Covey; Jan H Beumer
Liquid chromatography-tandem mass spectrometric assay for the quantitation in human plasma of the novel indenoisoquinoline topoisomerase I inhibitors, NSC 743400 and NSC 725776.
Journal of pharmaceutical and biomedical analysis 2010;52(5):714-20.
2009: Robert A Parise; Merrill J Egorin; Susan Lubawy; Dhvani D Shah; Wei Zhou; Jan H Beumer
A high-performance liquid chromatography-mass spectrometry assay for quantitation of the tyrosine kinase inhibitor nilotinib in human plasma and serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(20-21):1894-900.
2009: Shivendra V Singh; Renaud Warin; Dong Xiao; Anna A Powolny; Silvia D Stan; Julie A Arlotti; Yan Zeng; Eun-Ryeong Hahm; Stanley W Marynowski; Ajay Bommareddy; Dhimant Desai; Shantu Amin; Robert A Parise; Jan H Beumer; William Chambers
Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.
Cancer research 2009;69(5):2117-25.
2009: Jianxia Guo; Robert A Parise; Erin Joseph; Merrill J Egorin; John Lazo; Edward V Prochownik; Julie L Eiseman
Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice.
Cancer chemotherapy and pharmacology 2009;63(4):615-25.
2008: Robert A Parise; Mohammad Shawaqfeh; Merrill J Egorin; Jan H Beumer
Liquid chromatography-mass spectrometric assay for the quantitation in human plasma of ABT-888, an orally available, small molecule inhibitor of poly(ADP-ribose) polymerase.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;872(1-2):141-7.
2008: Jan H Beumer; Julie L Eiseman; Robert A Parise; Jeffry A Florian; Erin Joseph; David Z D'Argenio; Robert S Parker; Brittany Kay; Joseph M Covey; Merrill J Egorin
Plasma pharmacokinetics and oral bioavailability of 3,4,5,6-tetrahydrouridine, a cytidine deaminase inhibitor, in mice.
Cancer chemotherapy and pharmacology 2008;62(3):457-64.
2008: William C Zamboni; Sandra Strychor; Erin Joseph; Robert A Parise; Merrill J Egorin; Julie L Eiseman
Tumor, tissue, and plasma pharmacokinetic studies and antitumor response studies of docetaxel in combination with 9-nitrocamptothecin in mice bearing SKOV-3 human ovarian xenografts.
Cancer chemotherapy and pharmacology 2008;62(3):417-26.
2008: Jan H Beumer; Robert A Parise; Edward M Newman; James Doroshow; Timothy W Synold; Heinz-Josef Lenz; Merrill J Egorin
Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU).
Cancer chemotherapy and pharmacology 2008;62(2):363-8.
2008: Jan H Beumer; Julie L Eiseman; Robert A Parise; Erin Joseph; Joseph M Covey; Merrill J Egorin
Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3529-35.
2008: Joseph Gibbons; Merrill J Egorin; Ramesh K Ramanathan; Pingfu Fu; Daniel Mulkerin; Stephen Shibata; Chris H Takimoto; Sridhar Mani; Patricia M LoRusso; Jean L Grem; Anna Pavlick; Heinz-Josef Lenz; Susan M Flick; Sherrie Reynolds; Theodore F Lagattuta; Robert A Parise; Yanfeng Wang; Anthony J Murgo; S Percy Ivy; Scot C Remick
Phase I and pharmacokinetic study of imatinib mesylate in patients with advanced malignancies and varying degrees of renal dysfunction: a study by the National Cancer Institute Organ Dysfunction Working Group.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(4):570-6.
2008: Robert A Parise; Jan H Beumer; Cyrous O Kangani; Julianne L Holleran; Julie L Eiseman; Nicola F Smith; Joseph M Covey; Susan P Perrine; Merrill J Egorin
Liquid chromatography-mass spectrometric assay for quantitation of the short-chain fatty acid, 2,2-dimethylbutyrate (NSC 741804), in rat plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;862(1-2):168-74.
2007: William C Zamboni; Sandra Strychor; Erin Joseph; Dustin R Walsh; Beth A Zamboni; Robert A Parise; Margaret E Tonda; Ning Y Yu; Charles Engbers; Julie L Eiseman
Plasma, tumor, and tissue disposition of STEALTH liposomal CKD-602 (S-CKD602) and nonliposomal CKD-602 in mice bearing A375 human melanoma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(23):7217-23.
2007: Jianxia Guo; Robert A Parise; Erin Joseph; Jing Lan; Su-Shu Pan; Beomjun Joo; Merrill J Egorin; Peter Wipf; John Lazo; Julie L Eiseman
Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284).
Anticancer research 2007;27(5A):3067-73.
2007: Sakkaraiappan Ramalingam; Robert A Parise; Ramesh K Ramanathan; Ramesh K Ramananthan; Theodore F Lagattuta; Lori A Musguire; Ronald G Stoller; Douglas M Potter; Athanassios Argiris; James A Zwiebel; Merrill J Egorin; Chandra P Belani
Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(12):3605-10.
2007: Robert A Parise; Merrill J Egorin; Julie L Eiseman; Erin Joseph; Joseph M Covey; Jan H Beumer
Quantitative determination of the cytidine deaminase inhibitor tetrahydrouridine (THU) in mouse plasma by liquid chromatography/electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(13):1991-7.
2006: Jan H Beumer; Julie L Eiseman; Robert A Parise; Erin Joseph; Julianne L Holleran; Joseph M Covey; Merrill J Egorin
Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(24):7483-91.
2006: Robert A Parise; Merrill J Egorin; Beatriz Kanterewicz; Mohammed Taimi; Martin Petkovich; April M Lew; Samuel S Chuang; Mark Nichols; Talal El-Hefnawy; Pamela A Hershberger
CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer.
International journal of cancer. Journal international du cancer 2006;119(8):1819-28.
2006: William C Zamboni; Ramesh K Ramanathan; howard mcleod; Sridhar Mani; Douglas M Potter; Sandra Strychor; Lauren J Maruca; Cristi R King; Laura L Jung; Robert A Parise; Merrill J Egorin; Todd A Davis; Sharon Marsh
Disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in relation to ABC transporter genotypes.
Investigational new drugs 2006;24(5):393-401.
2006: Robert A Parise; Julianne L Holleran; Jan H Beumer; Sakkaraiappan Ramalingam; Merrill J Egorin
A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;840(2):108-15.
2006: William C Zamboni; SANJAY GOEL; Tahir Iqbal; Robert A Parise; Sandra Strychor; Trisha V W Repinski; Merrill J Egorin; Sridhar Mani
Clinical and pharmacokinetic study evaluating the effect of food on the disposition of 9-nitrocamptothecin and its 9-aminocamptothecin metabolite in patients with solid tumors.
Cancer chemotherapy and pharmacology 2006;57(5):631-9.
2006: Ramesh K Ramanathan; Marwan G Fakih; Sridhar Mani; Melvin Deutsch; Raymond P Perez; Mark A Ritter; Julie L Eiseman; S Percy Ivy; Donald L Trump; Chandra P Belani; Robert A Parise; Douglas M Potter; Merrill J Egorin
Phase I and pharmacokinetic study of the novel redox-active agent, motexafin gadolinium, with concurrent radiation therapy in patients with locally advanced pancreatic or biliary cancers.
Cancer chemotherapy and pharmacology 2006;57(4):465-74.
2005: Bernard J Komoroski; Robert A Parise; Merrill J Egorin; Stephen C Strom; Raman Venkataramanan
Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(19 Pt 1):6972-9.
2005: Julianne L Holleran; Robert A Parise; Erin Joseph; Julie L Eiseman; Joseph M Covey; Elizabeth R Glaze; Aleksander V. Lyubimov; Ya-Fei Chen; David Z D'Argenio; Merrill J Egorin
Plasma pharmacokinetics, oral bioavailability, and interspecies scaling of the DNA methyltransferase inhibitor, zebularine.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(10):3862-8.
2004: Robert A Parise; Barney R Sparrow; John W Merrill; Irma M Grossi; Joseph M Covey; James O Peggins; Merrill J Egorin
Liquid chromatography-electrospray tandem mass spectrometric assay suitable for quantitation of halofuginone in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;810(1):35-40.
2004: Julianne L Holleran; Julien Fourcade; Merrill J Egorin; Julie L Eiseman; Robert A Parise; Steven M Musser; Kevin D White; Joseph M Covey; Gerald L Forrest; Su-Shu Pan
In vitro metabolism of the phosphatidylinositol 3-kinase inhibitor, wortmannin, by carbonyl reductase.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(5):490-6.
2003: Julianne L Holleran; Merrill J Egorin; Eleanor G Zuhowski; Robert A Parise; Steven M Musser; Su-Shu Pan
Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media.
Analytical biochemistry 2003;323(1):19-25.
2003: Steven M Musser; Merrill J Egorin; Eleanor G Zuhowski; Deborah R Hamburger; Robert A Parise; Joseph M Covey; Kevin D White; Julie L Eiseman
Biliary excretion of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) and metabolites by Fischer 344 rats.
Cancer chemotherapy and pharmacology 2003;52(2):139-46.
2003: Robert A Parise; Ramesh K Ramanathan; Michael J Hayes; Merrill J Egorin
Liquid chromatographic-mass spectrometric assay for quantitation of imatinib and its main metabolite (CGP 74588) in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;791(1-2):39-44.
2003: Robert A Parise; Ramesh K Ramanathan; William C Zamboni; Merrill J Egorin
Sensitive liquid chromatography-mass spectrometry assay for quantitation of docetaxel and paclitaxel in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;783(1):231-6.
2001: K P Stecklair; Deborah R Hamburger; Merrill J Egorin; Robert A Parise; Joseph M Covey; Julie L Eiseman
Pharmacokinetics and tissue distribution of halofuginone (NSC 713205) in CD2F1 mice and Fischer 344 rats.
Cancer chemotherapy and pharmacology 2001;48(5):375-82.
2000: Robert A Parise; D R Miles; Merrill J Egorin
Sensitive high-performance liquid chromatographic assay for motexafin gadolinium and motexafin lutetium in human plasma.
Journal of chromatography. B, Biomedical sciences and applications 2000;749(2):145-52.
1998: Joseph A Carcillo; Kenneth R Korzekwa; G S Jones; Robert A Parise; Delbert G Gillespie; Michael J Whalen; P M Kochanek; Robert A Branch; Curtis K Kost
The cytochrome P450 suicide inhibitor, 1-aminobenzotriazole, sensitizes rats to zymosan-induced toxicity.
Research communications in molecular pathology and pharmacology 1998;102(1):57-68.
1998: Kenneth R Korzekwa; N Krishnamachary; Magang Shou; A Ogai; Robert A Parise; Allan E Rettie; F J Gonzalez; Timothy S Tracy
Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites.
Biochemistry 1998;37(12):4137-47.
1996: Joseph A Carcillo; Robert A Parise; Adedayo Adedoyin; R Frye; Robert A Branch; Marjorie Romkes
CYP2D6 mRNA expression in circulating peripheral blood mononuclear cells correlates with in vivo debrisoquine hydroxylase activity in extensive metabolizers.
Research communications in molecular pathology and pharmacology 1996;91(2):149-159.