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Hee-Won Park

Research Profile

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Chemicals & Drugs

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Genes & Molecular Sequences

Amino Acid Sequences

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Bacteriophage mu

Physiology

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Publications

TOP 3
Natallia Strushkevich; Sergey A Usanov; Limin Shen; Cheryl H Arrowsmith; Aled M Edwards; Andrei A Gilep; Hee-Won Park
Structural insights into aldosterone synthase substrate specificity and targeted inhibition.
Muthiah Kumaraswami; Hee-Won Park; Rajendra Rai; Lakshmi Avanigadda; Martha M Howe
Genetic analysis of phage Mu Mor protein amino acids involved in DNA minor groove binding and conformational changes.
Hui Wang; Limin Shen; Wolfram Tempel; Yufeng Tong; Susmita Borthakur; Matthias Buck; Prasanta K Hota; Soonjeung Kim; Buren Li; Lyudmila Nedyalkova; Hee-Won Park
Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs).

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All Publications

2013: Natallia Strushkevich; Sergey A Usanov; Limin Shen; Cheryl H Arrowsmith; Aled M Edwards; Andrei A Gilep; Hee-Won Park
Structural insights into aldosterone synthase substrate specificity and targeted inhibition.
Molecular endocrinology (Baltimore, Md.) 2013;27(2):315-24.
2011: Muthiah Kumaraswami; Hee-Won Park; Rajendra Rai; Lakshmi Avanigadda; Martha M Howe
Genetic analysis of phage Mu Mor protein amino acids involved in DNA minor groove binding and conformational changes.
The Journal of biological chemistry 2011;286(41):35852-62.
2011: Hui Wang; Limin Shen; Wolfram Tempel; Yufeng Tong; Susmita Borthakur; Matthias Buck; Prasanta K Hota; Soonjeung Kim; Buren Li; Lyudmila Nedyalkova; Hee-Won Park
Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs).
The Journal of biological chemistry 2011;286(29):26093-106.
2011: Natallia Strushkevich; Sergey Usanov; Tatyana Cherkesova; Irina Grabovec; Farrell Mackenzie; Hee-Won Park
Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(25):10139-43.
2010: Yufeng Tong; Wolfram Tempel; Hui Wang; Kaori Yamada; Limin Shen; Guillermo A Senisterra; Farrell Mackenzie; Athar H Chishti; Hee-Won Park
Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(47):20346-51.
2010: Bum Soo Hong; Abdellah Allali-Hassani; Wolfram Tempel; Patrick J Finerty; Farrell Mackenzie; Svetoslav Dimov; Masoud Vedadi; Hee-Won Park
Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
The Journal of biological chemistry 2010;285(21):16330-40.
2010: Natallia Strushkevich; Sergey A Usanov; Hee-Won Park
Structural basis of human CYP51 inhibition by antifungal azoles.
Journal of molecular biology 2010;397(4):1067-78.
2009: Yufeng Tong; Isaac Park; Bum-Soo Hong; Lyudmila Nedyalkova; Wolfram Tempel; Hee-Won Park
Crystal structure of human eIF5A1: insight into functional similarity of human eIF5A1 and eIF5A2.
Proteins 2009;75(4):1040-5.
2009: Yufeng Tong; Wolfram Tempel; Lyudmila Nedyalkova; Farrell Mackenzie; Hee-Won Park
Crystal structure of the N-acetylmannosamine kinase domain of GNE.
PloS one 2009;4(10):e7165.
2008: Natallia Strushkevich; Sergey A Usanov; Alexander N Plotnikov; Glenville Jones; Hee-Won Park
Structural analysis of CYP2R1 in complex with vitamin D3.
Journal of molecular biology 2008;380(1):95-106.
2008: Guillermo A Senisterra; Bum Soo Hong; Hee-Won Park; Masoud Vedadi
Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands.
Journal of biomolecular screening 2008;13(5):337-42.
2007: Wolfram Tempel; Wael M Rabeh; Katrina L Bogan; Peter Belenky; Marzena Wojcik; Heather Couch; Lyudmila Nedyalkova; Tianle Yang; Anthony A Sauve; Hee-Won Park; Charles Brenner
Nicotinamide riboside kinase structures reveal new pathways to NAD+.
PLoS biology 2007;5(10):e263.
2007: Bum Soo Hong; Guillermo Senisterra; Wael M Rabeh; Masoud Vedadi; Roberta Leonardi; Yong-Mei Zhang; Charles O Rock; Suzanne Jackowski; Hee-Won Park
Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.
The Journal of biological chemistry 2007;282(38):27984-93.
2007: Karthik K Shanmuganatham; Manimekalai Ravichandran; Martha M Howe; Hee-Won Park
Crystallization and preliminary X-ray analysis of phage Mu activator protein C in a complex with promoter DNA.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 7):620-3.
2007: Hee-Won Park
Structure determination of the motor domain of yeast kinesin kar3 by x-ray crystallography.
Methods in molecular biology (Clifton, N.J.) 2007;392():199-211.
2006: Bum Soo Hong; Mi Kyung Yun; Yong-Mei Zhang; Shigeru Chohnan; Charles O Rock; Stephen W White; Suzanne Jackowski; Hee-Won Park; Roberta Leonardi
Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties.
Structure (London, England : 1993) 2006;14(8):1251-61.
2006: Kristopher G Virga; Yong-Mei Zhang; Roberta Leonardi; Robert A Ivey; Kirk Edward Hevener; Hee-Won Park; Suzanne Jackowski; Charles O Rock; Richard E Lee
Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors.
Bioorganic & medicinal chemistry 2006;14(4):1007-20.
2004: Ramy Aziz; Shehab A Ismail; Hee-Won Park; Malak Kotb
Post-proteomic identification of a novel phage-encoded streptodornase, Sda1, in invasive M1T1 Streptococcus pyogenes.
Molecular microbiology 2004;54(1):184-97.
2004: Robert A Ivey; Yong-Mei Zhang; Kristopher G Virga; Kirk Edward Hevener; Richard E Lee; Charles O Rock; Suzanne Jackowski; Hee-Won Park
The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.
The Journal of biological chemistry 2004;279(34):35622-9.
2004: Muthiah Kumaraswami; Martha M Howe; Hee-Won Park
Crystal structure of the Mor protein of bacteriophage Mu, a member of the Mor/C family of transcription activators.
The Journal of biological chemistry 2004;279(16):16581-90.
2003: Mikyung Yun; Lakhu Keshvara; Cheon-Gil Park; Yong-Mei Zhang; J Bradley Dickerson; Jie Zheng; Charles O Rock; Tom Curran; Hee-Won Park
Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
The Journal of biological chemistry 2003;278(38):36572-81.