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John Park

Research Profile

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Mark Jesus M Magbanua; Adam B Olshen; Lauren E Eisenbud; Dan Pinkel; Ritu Roy; Hope S Rugo; Janet H Scott; Eduardo V Sosa; John W Park
Genomic profiling of isolated circulating tumor cells from metastatic breast cancer patients.
Laura A Petrillo; Paul T Spellman; Laura van't Veer; Nicholas J Wang; Max S Wicha; Denise M Wolf; Yuanyuan Xiao; Joe W Gray; Ann M Kapoun; Hasan Korkaya; John Lewicki; John W Park; Frederick L Baehner; Andrea Barczak; Laura J Esserman
Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors.
Hope S Rugo; Janet Scott; Alison T Stopeck; A Jo Chien; Sandra X Franco; Alexa Glencer; Clifford Hudis; Soumi Lahiri; Ben Nulsen; John W Park; Michael C Arbushites; Maura Dickler
A phase II study of lapatinib and bevacizumab as treatment for HER2-overexpressing metastatic breast cancer.

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2013: Mark Jesus M Magbanua; Adam B Olshen; Lauren E Eisenbud; Dan Pinkel; Ritu Roy; Hope S Rugo; Janet H Scott; Eduardo V Sosa; John W Park
Genomic profiling of isolated circulating tumor cells from metastatic breast cancer patients.
Cancer research 2013;73(1):30-40.
2012: Laura A Petrillo; Paul T Spellman; Laura van't Veer; Nicholas J Wang; Max S Wicha; Denise M Wolf; Yuanyuan Xiao; Joe W Gray; Ann M Kapoun; Hasan Korkaya; John Lewicki; John W Park; Frederick L Baehner; Andrea Barczak; Laura J Esserman
Xenografts faithfully recapitulate breast cancer-specific gene expression patterns of parent primary breast tumors.
Breast cancer research and treatment 2012;135(3):913-22.
2012: Hope S Rugo; Janet Scott; Alison T Stopeck; A Jo Chien; Sandra X Franco; Alexa Glencer; Clifford Hudis; Soumi Lahiri; Ben Nulsen; John W Park; Michael C Arbushites; Maura Dickler
A phase II study of lapatinib and bevacizumab as treatment for HER2-overexpressing metastatic breast cancer.
Breast cancer research and treatment 2012;134(1):13-20.
2012: Mark Jesus M Magbanua; Colin Collins; Dan Pinkel; Charles J Ryan; Janet H Scott; Jeff Simko; Eduardo V Sosa; John W Park
Isolation and genomic analysis of circulating tumor cells from castration resistant metastatic prostate cancer.
BMC cancer 2012;12():78.
2011: Laura P Serwer; Daryl C Drummond; Dmitri B Kirpotin; Karine Michaud; Charles O Noble; Tomoko Ozawa; John W Park; Michael D Prados; C David James
Investigation of intravenous delivery of nanoliposomal topotecan for activity against orthotopic glioblastoma xenografts.
Neuro-oncology 2011;13(12):1288-95.
2011: Laura J Esserman; Cheryl E Gillett; Stig Kreps; Dan H Moore; Elissa M Ozanne; John W Park; Vickram J Tandon; Pamela J Tsing; Andrew N J Tutt; Christina Yau; Frederick L Baehner; Philip W Chu; Robert E Chung; Christopher C Benz
Biologic markers determine both the risk and the timing of recurrence in breast cancer.
Breast cancer research and treatment 2011;129(2):607-16.
2011: John W Park
Disseminated tumor cells: the method is the message.
Breast cancer research and treatment 2011;125(3):739-40.
2010: Mark Barok; Margit Balazs; Viktória Lázár; Zsuzsa Rakosy; Eniko Toth; Andrea Treszl; György Vereb; Gail T Colbern; John W Park; Janos Szollosi
Characterization of a novel, trastuzumab resistant human breast cancer cell line.
Frontiers in bioscience (Elite edition) 2010;2():627-40.
2009: Prema P Peethambaram; Michelle E Melisko; Kristine J Rinn; Steven R Alberts; Nicole M Provost; Lori A Jones; Robert B Sims; Lisa R C Lin; Mark W Frohlich; John W Park
A phase I trial of immunotherapy with lapuleucel-T (APC8024) in patients with refractory metastatic tumors that express HER-2/neu.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(18):5937-44.
2008: John W Park; Richard M Neve; Janos Szollosi; Christopher C Benz
Unraveling the biologic and clinical complexities of HER2.
Clinical breast cancer 2008;8(5):392-401.
2007: Michal T Krauze; Charles O Noble; Tomohiro Kawaguchi; Daryl Drummond; Dmitri B Kirpotin; Yoji Yamashita; Erika Kullberg; John R Forsayeth; John W Park; Krystof S Bankiewicz
Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts.
Neuro-oncology 2007;9(4):393-403.
2007: Laura J Esserman; Yiwey Shieh; John W Park; Elissa M Ozanne
A role for biomarkers in the screening and diagnosis of breast cancer in younger women.
Expert review of molecular diagnostics 2007;7(5):533-44.
2007: John W Park; Michelle E Melisko; Laura J Esserman; Lori A Jones; Jami Breen Wollan; Robert Sims
Treatment with autologous antigen-presenting cells activated with the HER-2 based antigen Lapuleucel-T: results of a phase I study in immunologic and clinical activity in HER-2 overexpressing breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(24):3680-7.
2007: Jorge A Garcia; Jonathan E Rosenberg; Vivian Weinberg; Janet Scott; Mark Frohlich; John W Park; Eric J Small
Evaluation and significance of circulating epithelial cells in patients with hormone-refractory prostate cancer.
BJU international 2007;99(3):519-24.
2007: Yoji Yamashita; Michal T Krauze; Tomohiro Kawaguchi; Charles O Noble; Daryl C Drummond; John W Park; Krystof S Bankiewicz
Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts.
Neuro-oncology 2007;9(1):20-8.
2006: Mark E Hayes; Daryl C Drummond; Keelung Hong; W W Zheng; V A Khorosheva; J A Cohen; Noble C O; John W Park; James D Marks; Christopher C Benz; Dmitri B Kirpotin
Increased target specificity of anti-HER2 genospheres by modification of surface charge and degree of PEGylation.
Molecular pharmaceutics 2006;3(6):726-36.
2006: Michal T Krauze; John R Forsayeth; John W Park; Krystof S Bankiewicz
Real-time imaging and quantification of brain delivery of liposomes.
Pharmaceutical research 2006;23(11):2493-504.
2006: Dmitri B Kirpotin; Daryl C Drummond; Yi Shao; M Refaat Shalaby; Keelung Hong; Ulrik B Nielsen; James D Marks; Christopher C Benz; John W Park
Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models.
Cancer research 2006;66(13):6732-40.
2006: Ryuta Saito; Michal T Krauze; Charles O Noble; Daryl C Drummond; Dmitri B Kirpotin; Mitchel S Berger; John W Park; Krystof S Bankiewicz
Convection-enhanced delivery of Ls-TPT enables an effective, continuous, low-dose chemotherapy against malignant glioma xenograft model.
Neuro-oncology 2006;8(3):205-14.
2006: Lisa Tesch; Yoji Yamashita; Hanna Mirek; Laszlo Tamas; Martha C Bohn; Charles Noble; John W Park; Krystof S Bankiewicz
The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(1):69-78.
2006: Ryuta Saito; Michal T Krauze; Charles O Noble; Matyas Tamas; Daryl C Drummond; Dmitri B Kirpotin; Mitchel S Berger; John W Park; Krystof S Bankiewicz
Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery.
Journal of neuroscience methods 2006;154(1-2):225-32.
2006: Christoph Mamot; Reto Ritschard; Willy Küng; John W Park; Richard Herrmann; Christoph F Rochlitz
EGFR-targeted immunoliposomes derived from the monoclonal antibody EMD72000 mediate specific and efficient drug delivery to a variety of colorectal cancer cells.
Journal of drug targeting 2006;14(4):215-23.
2006: Mark E Hayes; Daryl C Drummond; Keelung Hong; John W Park; James D Marks; Dmitri B Kirpotin
Assembly of nucleic acid-lipid nanoparticles from aqueous-organic monophases.
Biochimica et biophysica acta 2006;1758(4):429-42.
2006: Mark E Hayes; Daryl C Drummond; Dmitri B Kirpotin; W W Zheng; Charles O Noble; John W Park; James D Marks; Christopher C Benz; Keelung Hong
Genospheres: self-assembling nucleic acid-lipid nanoparticles suitable for targeted gene delivery.
Gene therapy 2006;13(7):646-51.
2006: Charles O Noble; Michal T Krauze; Daryl C Drummond; Yoji Yamashita; Ryuta Saito; Mitchel S Berger; Dmitri B Kirpotin; Krystof S Bankiewicz; John W Park
Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy.
Cancer research 2006;66(5):2801-6.
2005: Christoph Mamot; Daryl C Drummond; Charles O Noble; Verena Kallab; Zexiong Guo; Keelung Hong; Dmitri B Kirpotin; John W Park
Epidermal growth factor receptor-targeted immunoliposomes significantly enhance the efficacy of multiple anticancer drugs in vivo.
Cancer research 2005;65(24):11631-8.
2005: Ryuta Saito; Michal T Krauze; John Bringas; Charles O Noble; Tracy R McKnight; Pamela Jackson; Michael F Wendland; Christoph Mamot; Daryl C Drummond; Dmitri B Kirpotin; Keelung Hong; Mitchel S Berger; John W Park; Krystof S Bankiewicz
Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain.
Experimental neurology 2005;196(2):381-9.
2005: Michal T Krauze; Tracy R McKnight; Yoji Yamashita; John Bringas; Charles O Noble; Ryuta Saito; Karsten Geletneky; John R Forsayeth; Mitchel S Berger; Pamela Jackson; John W Park; Krystof S Bankiewicz
Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging.
Brain research. Brain research protocols 2005;16(1-3):20-6.
2005: Michal T Krauze; Ryuta Saito; Charles O Noble; Matyas Tamas; John Bringas; John W Park; Mitchel S Berger; Krystof S Bankiewicz
Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents.
Journal of neurosurgery 2005;103(5):923-9.
2005: Glenn Liu; Hope S Rugo; George Wilding; Teresa M McShane; Jeffrey L Evelhoch; Chaan Ng; Edward Jackson; Frederick Kelcz; Benjamin M Yeh; Fred T Lee; Chusilp Charnsangavej; John W Park; Edward A Ashton; Heidi M Steinfeldt; Yazdi K Pithavala; Steven D Reich; Roy S Herbst
Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a phase I study.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(24):5464-73.
2005: Hope S Rugo; Roy S Herbst; Glenn Liu; John W Park; Merrill S Kies; Heidi M Steinfeldt; Yazdi K Pithavala; Steven D Reich; James L Freddo; George Wilding
Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(24):5474-83.
2005: Michael J Campbell; Janet Scott; Holden T Maecker; John W Park; Laura J Esserman
Immune dysfunction and micrometastases in women with breast cancer.
Breast cancer research and treatment 2005;91(2):163-71.
2005: Michelle E Melisko; Sandeep Kunwar; Michael Prados; Mitchel S Berger; John W Park
Brain metastases of breast cancer.
Expert review of anticancer therapy 2005;5(2):253-68.
2004: Nicholas J Robert; Charles L Vogel; I Craig Henderson; Joseph A Sparano; Melvin R Moore; Paula Silverman; Beth Overmoyer; Charles L Shapiro; John W Park; Gail T Colbern; Eric P Winer; Alberto Gabizon
The role of the liposomal anthracyclines and other systemic therapies in the management of advanced breast cancer.
Seminars in oncology 2004;31(6 Suppl 13):106-46.
2004: Charles O Noble; Dmitri B Kirpotin; Mark E Hayes; Christoph Mamot; Keelung Hong; John W Park; Christopher C Benz; James D Marks; Daryl C Drummond
Development of ligand-targeted liposomes for cancer therapy.
Expert opinion on therapeutic targets 2004;8(4):335-53.
2004: John W Park; Robert S Kerbel; Gary J Kelloff; J Carl Barrett; Bruce A Chabner; David R Parkinson; Jonathan Peck; Raymond W Ruddon; Caroline C Sigman; Dennis J Slamon
Rationale for biomarkers and surrogate end points in mechanism-driven oncology drug development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3885-96.
2004: Gary J Kelloff; Robert C Bast; Donald S Coffey; Anthony V D'Amico; Robert S Kerbel; John W Park; Raymond W Ruddon; Gordon J S Rustin; Richard L Schilsky; Caroline C Sigman; George Vande Woude
Biomarkers, surrogate end points, and the acceleration of drug development for cancer prevention and treatment: an update prologue.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3881-4.
2004: Christoph Mamot; John B Nguyen; Micheal Pourdehnad; Piotr Hadaczek; Ryuta Saito; John Bringas; Daryl C Drummond; Keelung Hong; Dmitri B Kirpotin; Tracy R McKnight; Mitchel S Berger; John W Park; Krystof S Bankiewicz
Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery.
Journal of neuro-oncology 2004;68(1):1-9.
2004: Ryuta Saito; John Bringas; Tracy R McKnight; Michael F Wendland; Christoph Mamot; Daryl C Drummond; Dmitri B Kirpotin; John W Park; Mitchel S Berger; Krystof S Bankiewicz
Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging.
Cancer research 2004;64(7):2572-9.
2003: Christoph Mamot; Daryl C Drummond; Keelung Hong; Dmitri B Kirpotin; John W Park
Liposome-based approaches to overcome anticancer drug resistance.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2003;6(5):271-9.
2003: Christoph Mamot; Daryl C Drummond; Udo Greiser; Keelung Hong; Dmitri B Kirpotin; James D Marks; John W Park
Epidermal growth factor receptor (EGFR)-targeted immunoliposomes mediate specific and efficient drug delivery to EGFR- and EGFRvIII-overexpressing tumor cells.
Cancer research 2003;63(12):3154-61.
2002: Ulrik B Nielsen; Dmitri B Kirpotin; Edward M Pickering; Keelung Hong; John W Park; M Refaat Shalaby; Yi Shao; Christopher C Benz; James D Marks
Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis.
Biochimica et biophysica acta 2002;1591(1-3):109-118.
2002: John W Park; Keelung Hong; Dmitri B Kirpotin; Gail T Colbern; Refaat Shalaby; Jose Baselga; Yvonne Shao; Ulrik B Nielsen; James D Marks; Dan Moore; Demetrios Papahadjopoulos; Christopher C Benz
Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(4):1172-81.
2001: John W Park; Dmitri B Kirpotin; Keelung Hong; Refaat Shalaby; Yvonne Shao; Ulrik B Nielsen; James D Marks; Demetrios Papahadjopoulos; Christopher C Benz
Tumor targeting using anti-her2 immunoliposomes.
Journal of controlled release : official journal of the Controlled Release Society 2001;74(1-3):95-113.
1999: Keelung Hong; Dmitri B Kirpotin; John W Park; Yvonne Shao; Refaat Shalaby; Gail T Colbern; Christopher C Benz; Demetrios Papahadjopoulos
Anti-HER2 immunoliposomes for targeted drug delivery.
Annals of the New York Academy of Sciences 1999;886():293-6.
1998: O Meyer; Dmitri B Kirpotin; Keelung Hong; B Sternberg; John W Park; M C Woodle; Demetrios Papahadjopoulos
Cationic liposomes coated with polyethylene glycol as carriers for oligonucleotides.
The Journal of biological chemistry 1998;273(25):15621-7.
1997: John W Park; Keelung Hong; Dmitri B Kirpotin; O Meyer; Demetrios Papahadjopoulos; Christopher C Benz
Anti-HER2 immunoliposomes for targeted therapy of human tumors.
Cancer letters 1997;118(2):153-60.
1997: Dmitri B Kirpotin; John W Park; Keelung Hong; S Zalipsky; W L Li; P Carter; Christopher C Benz; Demetrios Papahadjopoulos
Sterically stabilized anti-HER2 immunoliposomes: design and targeting to human breast cancer cells in vitro.
Biochemistry 1997;36(1):66-75.
1997: John W Park; Keelung Hong; Dmitri B Kirpotin; Demetrios Papahadjopoulos; Christopher C Benz
Immunoliposomes for cancer treatment.
Advances in pharmacology (San Diego, Calif.) 1997;40():399-435.