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Margareta Berggren

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Margareta I Berggren; Sivanandane Sittadjody; Zuohe Song; Jean-Louis Samira; Randy Burd; Emmanuelle J Meuillet
Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells.
Daruka Mahadevan; Garth Powis; Eugene A. Mash Jr.; Benjamin George; Vijay Gokhale; Shuxing Zhang; Kishore Shakalya; Lei Du-Cuny; Margareta I Berggren; M Ahad Ali; Umasish Jana; Nathan T Ihle; Sylvestor Moses; Chloe Franklin; Satya Narayan; Nikhil Shirahatti; Emmanuelle J Meuillet
Discovery of a novel class of AKT pleckstrin homology domain inhibitors.
Nathan T Ihle; Gillian Paine-Murrieta; Margareta I Berggren; Amanda Baker; Wendy R Tate; Peter Wipf; Robert T Abraham; D Lynn Kirkpatrick; Garth Powis
The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts.

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All Publications

2009: Margareta I Berggren; Sivanandane Sittadjody; Zuohe Song; Jean-Louis Samira; Randy Burd; Emmanuelle J Meuillet
Sodium selenite increases the activity of the tumor suppressor protein, PTEN, in DU-145 prostate cancer cells.
Nutrition and cancer 2009;61(3):322-31.
2008: Daruka Mahadevan; Garth Powis; Eugene A. Mash Jr.; Benjamin George; Vijay Gokhale; Shuxing Zhang; Kishore Shakalya; Lei Du-Cuny; Margareta I Berggren; M Ahad Ali; Umasish Jana; Nathan T Ihle; Sylvestor Moses; Chloe Franklin; Satya Narayan; Nikhil Shirahatti; Emmanuelle J Meuillet
Discovery of a novel class of AKT pleckstrin homology domain inhibitors.
Molecular cancer therapeutics 2008;7(9):2621-32.
2005: Nathan T Ihle; Gillian Paine-Murrieta; Margareta I Berggren; Amanda Baker; Wendy R Tate; Peter Wipf; Robert T Abraham; D Lynn Kirkpatrick; Garth Powis
The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts.
Molecular cancer therapeutics 2005;4(9):1349-57.
2004: Emmanuelle J Meuillet; Daruka Mahadevan; Margareta I Berggren; Amy Coon; Garth Powis
Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity.
Archives of biochemistry and biophysics 2004;429(2):123-33.
2004: Peter Wipf; Daniel J Minion; Robert J Halter; Margareta I Berggren; Caroline B Ho; Gary G Chiang; Lynn Kirkpatrick; Robert Abraham; Garth Powis
Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin.
Organic & biomolecular chemistry 2004;2(13):1911-20.
2004: Nathan T Ihle; Ryan Williams; Sherry Chow; Wade M Chew; Margareta I Berggren; Gillian Paine-Murrieta; Daniel J Minion; Robert J Halter; Peter Wipf; Robert Abraham; Lynn Kirkpatrick; Garth Powis
Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling.
Molecular cancer therapeutics 2004;3(7):763-72.
2003: Larisa Nonn; Margareta I Berggren; Garth Powis
Increased expression of mitochondrial peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis.
Molecular cancer research : MCR 2003;1(9):682-9.
2003: Emmanuelle J Meuillet; Daruka Mahadevan; Hariprasad Vankayalapati; Margareta I Berggren; Ryan Williams; Amy Coon; Alan P Kozikowski; Garth Powis
Specific inhibition of the Akt1 pleckstrin homology domain by D-3-deoxy-phosphatidyl-myo-inositol analogues.
Molecular cancer therapeutics 2003;2(4):389-99.
2001: Margareta I Berggren; Bryan Husbeck; Betty K Samulitis; Amanda F Baker; Alfred Gallegos; Garth Powis
Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin.
Archives of biochemistry and biophysics 2001;392(1):103-9.
2001: Y Hu; Emmanuelle J Meuillet; Margareta I Berggren; Garth Powis; Alan P Kozikowski
3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth.
Bioorganic & medicinal chemistry letters 2001;11(2):173-6.
2001: Bryan Husbeck; Margareta I Berggren; Garth Powis
DNA microarray reveals increased expression of thioredoxin peroxidase in thioredoxin-1 transfected cells and its functional consequences.
Advances in experimental medicine and biology 2001;500():157-68.
2000: Y Hu; Lixin Qiao; Shaomeng Wang; Suo-Bao Rong; Emmanuelle J Meuillet; Margareta I Berggren; Alfred Gallegos; Garth Powis; Alan P Kozikowski
3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth.
Journal of medicinal chemistry 2000;43(16):3045-51.
1998: D Lynn Kirkpatrick; M Kuperus; M Dowdeswell; N Potier; Lynda J Donald; MW Kunkel; Margareta I Berggren; M Angulo; Garth Powis
Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides.
Biochemical pharmacology 1998;55(7):987-94.
1997: Alfred Gallegos; Margareta I Berggren; JR Gasdaska; Garth Powis
Mechanisms of the regulation of thioredoxin reductase activity in cancer cells by the chemopreventive agent selenium.
Cancer research 1997;57(21):4965-70.
1997: Margareta I Berggren; Alfred Gallegos; JR Gasdaska; Garth Powis
Cellular thioredoxin reductase activity is regulated by selenium.
Anticancer research 1997;17(5A):3377-80.
1997: Garth Powis; JR Gasdaska; PY Gasdaska; Margareta I Berggren; D Lynn Kirkpatrick; Lars Engman; Ian A Cotgreave; M Angulo; Amanda Baker
Selenium and the thioredoxin redox system: effects on cell growth and death.
Oncology research 1997;9(6-7):303-12.
1996: Alfred Gallegos; JR Gasdaska; Charles W Taylor; Gillian Paine-Murrieta; D Goodman; P Y Gasdaska; Margareta I Berggren; Margaret M Briehl; Garth Powis
Transfection with human thioredoxin increases cell proliferation and a dominant-negative mutant thioredoxin reverses the transformed phenotype of human breast cancer cells.
Cancer research 1996;56(24):5765-70.
1996: JR Gasdaska; D Lynn Kirkpatrick; William R Montfort; M Kuperus; S R Hill; Margareta I Berggren; Garth Powis
Oxidative inactivation of thioredoxin as a cellular growth factor and protection by a Cys73-->Ser mutation.
Biochemical pharmacology 1996;52(11):1741-7.
1996: Margareta I Berggren; Alfred Gallegos; JR Gasdaska; P Y Gasdaska; James Warneke; Garth Powis
Thioredoxin and thioredoxin reductase gene expression in human tumors and cell lines, and the effects of serum stimulation and hypoxia.
Anticancer research 1996;16(6B):3459-66.
1995: JR Gasdaska; Margareta I Berggren; Garth Powis
Cell growth stimulation by the redox protein thioredoxin occurs by a novel helper mechanism.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(12):1643-50.
1995: T Frew; Garth Powis; Margareta I Berggren; Alfred Gallegos; R T Abraham; C L Ashendel; Leon H Zalkow; C Hudson; E Gruszecka-Kowalik; E M Burgess
Novel quinone antiproliferative inhibitors of phosphatidylinositol-3-kinase.
Anti-cancer drug design 1995;10(4):347-59.
1995: Alan P Kozikowski; J J Kiddle; T Frew; Margareta I Berggren; Garth Powis
Synthesis and biology of 1D-3-deoxyphosphatidylinositol: a putative antimetabolite of phosphatidylinositol-3-phosphate and an inhibitor of cancer cell colony formation.
Journal of medicinal chemistry 1995;38(7):1053-6.
1995: J E Oblong; Margareta I Berggren; P Y Gasdaska; S R Hill; Garth Powis
Site-directed mutagenesis of Lys36 in human thioredoxin: the highly conserved residue affects reduction rates and growth stimulation but is not essential for the redox protein's biochemical or biological properties.
Biochemistry 1995;34(10):3319-24.
1995: Garth Powis; Margareta I Berggren; Alfred Gallegos; T Frew; S Hill; Alan P Kozikowski; R Bonjouklian; Leon H Zalkow; R Abraham; C Ashendel
Advances with phospholipid signalling as a target for anticancer drug development.
Acta biochimica Polonica 1995;42(4):395-403.
1994: T Frew; Garth Powis; Margareta I Berggren; R T Abraham; C L Ashendel; Leon H Zalkow; C Hudson; S Qazia; E Gruszecka-Kowalik; R Merriman
A multiwell assay for inhibitors of phosphatidylinositol-3-kinase and the identification of natural product inhibitors.
Anticancer research 1994;14(6B):2425-8.
1994: Garth Powis; R Bonjouklian; Margareta I Berggren; Alfred Gallegos; R Abraham; C Ashendel; Leon H Zalkow; W F Matter; J Dodge; G Grindey
Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.
Cancer research 1994;54(9):2419-23.
1994: J E Oblong; Margareta I Berggren; P Y Gasdaska; Garth Powis
Site-directed mutagenesis of active site cysteines in human thioredoxin produces competitive inhibitors of human thioredoxin reductase and elimination of mitogenic properties of thioredoxin.
The Journal of biological chemistry 1994;269(16):11714-20.
1994: J E Oblong; Margareta I Berggren; Garth Powis
Biochemical, structural, and biological properties of human thioredoxin active site peptides.
FEBS letters 1994;343(1):81-4.
1994: Garth Powis; J E Oblong; P Y Gasdaska; Margareta I Berggren; S R Hill; D Lynn Kirkpatrick
The thioredoxin/thioredoxin reductase redox system and control of cell growth.
Oncology research 1994;6(10-11):539-44.
1993: Margareta I Berggren; L A Burns; R T Abraham; Garth Powis
Inhibition of protein tyrosine phosphatase by the antitumor agent gallium nitrate.
Cancer research 1993;53(8):1862-6.
1991: K Olafsdottir; Ake Ryrfeldt; Luigi Atzori; Margareta I Berggren; P Moldéus
Hydroperoxide-induced broncho- and vasoconstriction in the isolated rat lung.
Experimental lung research 1991;17(3):615-27.
1991: K Olafsdóttir; Luigi Atzori; Ake Ryrfeldt; Margareta I Berggren; M Kumlin; P Moldéus
Mechanisms of hydroperoxide-induced broncho- and vasoconstriction in isolated and perfused rat lung.
Pharmacology & toxicology 1991;68(3):181-6.
1990: Ake Ryrfeldt; K Olafsdottir; Margareta I Berggren; P Moldéus
Effects of some autacoids on breathing and perfusion flow in the isolated perfused rat lung.
Pharmacology & toxicology 1990;66(4):312-4.
1988: Ian A Cotgreave; M Weis; Margareta I Berggren; M S Sandy; P W Moldéus
Determination of the intracellular protein thiol distribution of hepatocytes using monobromobimane derivatisation of intact cells and isolated subcellular fractions.
Journal of biochemical and biophysical methods 1988;16(4):247-54.
1988: Ake Ryrfeldt; F Kröll; Margareta I Berggren; P Moldéus
Hydroperoxide and cigarette smoke induced effects on lung mechanics and glutathione status in rat isolated perfused and ventilated lungs.
Life sciences 1988;42(15):1439-45.
1987: Ian A Cotgreave; M S Sandy; Margareta I Berggren; P W Moldéus; M T Smith
N-acetylcysteine and glutathione-dependent protective effect of PZ51 (Ebselen) against diquat-induced cytotoxicity in isolated hepatocytes.
Biochemical pharmacology 1987;36(18):2899-904.
1987: Ian A Cotgreave; Margareta I Berggren; T W Jones; J Dawson; P Moldéus
Gastrointestinal metabolism of N-acetylcysteine in the rat, including an assay for sulfite in biological systems.
Biopharmaceutics & drug disposition 1987;8(4):377-86.
1986: P Moldéus; I A Cotgreave; Margareta I Berggren
Lung protection by a thiol-containing antioxidant: N-acetylcysteine.
Respiration; international review of thoracic diseases 1986;50 Suppl 1():31-42.