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David Parker

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TOP 3
David Parker; Bradley P Waldron; Dmitrii S Yufit
Crystallographic and solution NMR structural analyses of four hexacoordinated gallium(iii) complexes based on ligands derived from 6-amino-perhydro-1,4-diazepine.
Brian K McMahon; Robert Pal; David Parker
A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells.
David Parker; Bradley P Waldron
Conformational analysis and synthetic approaches to polydentate perhydro-diazepine ligands for the complexation of gallium(III).

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All Publications

2013: David Parker; Bradley P Waldron; Dmitrii S Yufit
Crystallographic and solution NMR structural analyses of four hexacoordinated gallium(iii) complexes based on ligands derived from 6-amino-perhydro-1,4-diazepine.
Dalton transactions (Cambridge, England : 2003) 2013;42(22):8001-8.
2013: Brian K McMahon; Robert Pal; David Parker
A bright and responsive europium probe for determination of pH change within the endoplasmic reticulum of living cells.
Chemical communications (Cambridge, England) 2013;49(47):5363-5.
2013: David Parker; Bradley P Waldron
Conformational analysis and synthetic approaches to polydentate perhydro-diazepine ligands for the complexation of gallium(III).
Organic & biomolecular chemistry 2013;11(17):2827-38.
2013: James W Walton; Jurriaan M Zwier; Horst Puschmann; Marine Soulie; Chantal Andraud; Adrien Bourdolle; Stephen J Butler; Martina Delbianco; Laurent Lamarque; Olivier MAURY; Brian K McMahon; Robert Pal; David Parker
Very bright europium complexes that stain cellular mitochondria.
Chemical communications (Cambridge, England) 2013;49(16):1600-2.
2013: Stephen J Butler; David Parker
Anion binding in water at lanthanide centres: from structure and selectivity to signalling and sensing.
Chemical Society reviews 2013;42(4):1652-66.
2013: Alexander M Funk; Peter Harvey; Alan M Kenwright; Pascal H Fries; David Parker
Experimental measurement and theoretical assessment of fast lanthanide electronic relaxation in solution with four series of isostructural complexes.
The journal of physical chemistry. A 2013;117(5):905-17.
2013: Bradley P Waldron; Dmitry S Yufit; Melanie Zimny; Carsten Burchardt; David Parker; Frank Roesch
Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68.
Chemical communications (Cambridge, England) 2013;49(6):579-81.
2012: Rachel Carr; Nicholas H Evans; David Parker
Lanthanide complexes as chiral probes exploiting circularly polarized luminescence.
Chemical Society reviews 2012;41(23):7673-86.
2012: Rachel Carr; Lorenzo Di Bari; Samuele Lo Piano; David Parker; Robert D Peacock; John M Sanderson
A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence.
Dalton transactions (Cambridge, England : 2003) 2012;41(42):13154-8.
2012: David G Smith; Robert Pal; David Parker
Measuring equilibrium bicarbonate concentrations directly in cellular mitochondria and in human serum using europium/terbium emission intensity ratios.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(37):11604-13.
2012: David G Smith; Brian K McMahon; Robert Pal; David Parker
Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes.
Chemical communications (Cambridge, England) 2012;48(68):8520-2.
2012: James W Walton; Dmitry S Yufit; Mauro Botta; Rachel Carr; Sara De Pinto; Nicholas H Evans; Alexander M Funk; Alan M Kenwright; David Parker; Ka-Leung Wong
Isostructural series of nine-coordinate chiral lanthanide complexes based on triazacyclononane.
Inorganic chemistry 2012;51(15):8042-56.
2012: Peter Harvey; Anurag Mishra; Kirsten H Chalmers; Elena De Luca; David Parker
Paramagnetic 19F chemical shift probes that respond selectively to calcium or citrate levels and signal ester hydrolysis.
Chemistry (Weinheim an der Bergstrasse, Germany) 2012;18(28):8748-57.
2012: Aruna S Prakash; Martin Sims; Michael J P Smith; Peter Stokes; Ci Yan; Anthony W T Bristow; Glenn Hurst; Zied Kaabia; David Parker; Jackie A Mosely
Using electron induced dissociation (EID) on an LC time-scale to characterize a mixture of analogous small organic molecules.
Journal of the American Society for Mass Spectrometry 2012;23(5):850-7.
2011: James W Walton; Lorenzo Di Bari; David Parker; Gennaro Pescitelli; Horst Puschmann; Dmitry S Yufit
Structure, resolution and chiroptical analysis of stable lanthanide complexes of a pyridylphenylphosphinate triazacyclononane ligand.
Chemical communications (Cambridge, England) 2011;47(45):12289-91.
2011: Kirsten H Chalmers; Alan M Kenwright; David Parker; Andrew M Blamire
19F-lanthanide complexes with increased sensitivity for 19F-MRI: optimization of the MR acquisition.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2011;66(4):931-6.
2011: Robert Pal; Andrew Beeby; David Parker
Analysis of citrate in low-volume seminal fluid samples using a time-gated measurement of europium luminescence.
Journal of pharmaceutical and biomedical analysis 2011;56(2):352-8.
2011: David G Smith; Ga-Lai Law; Benjamin S Murray; Robert Pal; David Parker; Ka-Leung Wong
Evidence for the optical signalling of changes in bicarbonate concentration within the mitochondrial region of living cells.
Chemical communications (Cambridge, England) 2011;47(26):7347-9.
2011: Anurag Mishra; Nikos K Logothetis; David Parker
Critical in vitro evaluation of responsive MRI contrast agents for calcium and zinc.
Chemistry (Weinheim an der Bergstrasse, Germany) 2011;17(5):1529-37.
2011: Kirsten H Chalmers; Mauro Botta; David Parker
Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.
Dalton transactions (Cambridge, England : 2003) 2011;40(4):904-13.
2010: Daniela Imperio; Giovanni B Giovenzana; Ga-Lai Law; David Parker; James W Walton
Synthesis and comparative anion binding profiles of two di-aqua Eu(III) complexes.
Dalton transactions (Cambridge, England : 2003) 2010;39(41):9897-903.
2010: Ga-Lai Law; Cornelia Man; David Parker; James W Walton
Observation of the selective staining of chromosomal DNA in dividing cells using a luminescent terbium(III) complex.
Chemical communications (Cambridge, England) 2010;46(14):2391-3.
2010: Elizabeth J New; David Parker; David G Smith; James W Walton
Development of responsive lanthanide probes for cellular applications.
Current opinion in chemical biology 2010;14(2):238-46.
2010: Kirsten H Chalmers; Elena De Luca; Naomi H M Hogg; Alan M Kenwright; Ilya Kuprov; David Parker; Mauro Botta; J Ian Wilson; Andrew M Blamire
Design principles and theory of paramagnetic fluorine-labelled lanthanide complexes as probes for (19)F magnetic resonance: a proof-of-concept study.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(1):134-48.
2009: Ga-Lai Law; Robert Pal; Lars O Palsson; David Parker; Ka-Leung Wong
Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing.
Chemical communications (Cambridge, England) 2009;(47):7321-3.
2009: Ga-Lai Law; David Parker; Siobhan L Richardson; Ka-Leung Wong
The mechanism of quenching of the lanthanide excited state for optical probes using sensitised emission.
Dalton transactions (Cambridge, England : 2003) 2009;(40):8481-4.
2009: Craig P Montgomery; Benjamin S Murray; Elizabeth J New; Robert Pal; David Parker
Cell-penetrating metal complex optical probes: targeted and responsive systems based on lanthanide luminescence.
Accounts of chemical research 2009;42(7):925-37.
2009: Robert Pal; David Parker; Leslie C Costello
A europium luminescence assay of lactate and citrate in biological fluids.
Organic & biomolecular chemistry 2009;7(8):1525-8.
2009: Elisa M Elemento; David Parker; Silvio Aime; Eliana Gianolio; Luciano Lattuada
Variation of water exchange dynamics with ligand structure and stereochemistry in lanthanide complexes based on 1,4-diazepine derivatives.
Organic & biomolecular chemistry 2009;7(6):1120-31.
2009: Elizabeth J New; David Parker
The mechanism of cell uptake for luminescent lanthanide optical probes: the role of macropinocytosis and the effect of enhanced membrane permeability on compartmentalisation.
Organic & biomolecular chemistry 2009;7(5):851-5.
2009: Elizabeth J New; David Parker; Robert D Peacock
Comparative study of the constitution and chiroptical properties of emissive terbium and europium complexes with a common tetraazatriphenylene sensitiser; the nature of the sensitiser determines quenching sensitivity and cellular uptake.
Dalton transactions (Cambridge, England : 2003) 2009;(4):672-9.
2008: Craig P Montgomery; Elizabeth J New; David Parker; Robert D Peacock
Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence.
Chemical communications (Cambridge, England) 2008;(36):4261-3.
2008: Filip Kielar; Ga-Lai Law; Elizabeth J New; David Parker
The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use.
Organic & biomolecular chemistry 2008;6(13):2256-8.
2008: Benjamin S Murray; Elizabeth J New; Robert Pal; David Parker
Critical evaluation of five emissive europium(III) complexes as optical probes: correlation of cytotoxicity, anion and protein affinity with complex structure, stability and intracellular localisation profile.
Organic & biomolecular chemistry 2008;6(12):2085-94.
2008: Alan M Kenwright; Ilya Kuprov; Elena De Luca; David Parker; Shashi U Pandya; P Kanthi Senanayake; David G Smith
19F NMR based pH probes: lanthanide(III) complexes with pH-sensitive chemical shifts.
Chemical communications (Cambridge, England) 2008;(22):2514-6.
2008: Filip Kielar; Aileen Congreve; Ga-Lai Law; Elizabeth J New; David Parker; Kin-Ling Wong; Pilar Castreno; Javier de Mendoza
Two-photon microscopy study of the intracellular compartmentalisation of emissive terbium complexes and their oligo-arginine and oligo-guanidinium conjugates.
Chemical communications (Cambridge, England) 2008;(21):2435-7.
2008: Robert Pal; David Parker
A ratiometric optical imaging probe for intracellular pH based on modulation of europium emission.
Organic & biomolecular chemistry 2008;6(6):1020-33.
2007: Lars-Olof Pålsson; Robert Pal; Benjamin S Murray; David Parker; Andrew Beeby
Two-photon absorption and photoluminescence of europium based emissive probes for bioactive systems.
Dalton transactions (Cambridge, England : 2003) 2007;(48):5726-34.
2007: Craig P Montgomery; David Parker; Laurent Lamarque
Effective and efficient sensitisation of terbium luminescence at 355 nm with cell permeable pyrazoyl-1-azaxanthone macrocyclic complexes.
Chemical communications (Cambridge, England) 2007;(37):3841-3.
2007: Filip Kielar; Craig P Montgomery; Elizabeth J New; David Parker; Robert A Poole; Siobhan L Richardson; Philip A Stenson
A mechanistic study of the dynamic quenching of the excited state of europium(III) and terbium(III) macrocyclic complexes by charge- or electron transfer.
Organic & biomolecular chemistry 2007;5(18):2975-82.
2007: P Kanthi Senanayake; Alan M Kenwright; David Parker; Susanna K van der Hoorn
Responsive fluorinated lanthanide probes for 19F magnetic resonance spectroscopy.
Chemical communications (Cambridge, England) 2007;(28):2923-5.
2007: Robert A Poole; Craig P Montgomery; Elizabeth J New; Aileen Congreve; David Parker; Mauro Botta
Identification of emissive lanthanide complexes suitable for cellular imaging that resist quenching by endogenous anti-oxidants.
Organic & biomolecular chemistry 2007;5(13):2055-62.
2007: Robert Pal; David Parker
A single component ratiometric pH probe with long wavelength excitation of europium emission.
Chemical communications (Cambridge, England) 2007;(5):474-6.
2006: Amber L Thompson; David Parker; David A Fulton; Judith A K Howard; Shashi U Pandya; Horst Puschmann; Kanthi Senanayake; Philip A Stenson; Alessandra Badari; Mauro Botta; Stefano Avedano; Silvio Aime
On the role of the counter-ion in defining water structure and dynamics: order, structure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes.
Dalton transactions (Cambridge, England : 2003) 2006;(47):5605-16.
2006: Kanthi Senanayake; Amber L Thompson; Judith A K Howard; Mauro Botta; David Parker
Synthesis and characterisation of dimeric eight-coordinate lanthanide(III) complexes of a macrocyclic tribenzylphosphinate ligand.
Dalton transactions (Cambridge, England : 2003) 2006;(45):5423-8.
2006: Robert A Poole; Filip Kielar; Siobhan L Richardson; Philip A Stenson; David Parker
A ratiometric and non-enzymatic luminescence assay for uric acid: differential quenching of lanthanide excited states by anti-oxidants.
Chemical communications (Cambridge, England) 2006;(39):4084-6.
2006: Paul Atkinson; Benjamin S Murray; David Parker
A cationic lanthanide complex binds selectively to phosphorylated tyrosine sites, aiding NMR analysis of the phosphorylated insulin receptor peptide fragment.
Organic & biomolecular chemistry 2006;4(16):3166-71.
2006: Philip A Stenson; Amber L Thompson; David Parker
Structural characterisation of a diprotonated ligand lanthanide complex--a key intermediate in lanthanide ion association and complex dissociation pathways.
Dalton transactions (Cambridge, England : 2003) 2006;(27):3291-3.
2006: Shashi Pandya; Junhua Yu; David Parker
Engineering emissive europium and terbium complexes for molecular imaging and sensing.
Dalton transactions (Cambridge, England : 2003) 2006;(23):2757-66.
2006: Paul Atkinson; Karen S Findlay; Filip Kielar; Robert Pal; David Parker; Robert A Poole; Horst Puschmann; Siobhan L Richardson; Philip A Stenson; Amber L Thompson; Junhau Yu
Azaxanthones and azathioxanthones are effective sensitisers for europium and terbium luminescence.
Organic & biomolecular chemistry 2006;4(9):1707-22.
2006: David A Fulton; Elisa M Elemento; Silvio Aime; Linda Chaabane; Mauro Botta; David Parker
Glycoconjugates of gadolinium complexes for MRI applications.
Chemical communications (Cambridge, England) 2006;(10):1064-6.
2006: Junhua Yu; David Parker; Robert Pal; Robert A Poole; Martin J Cann
A europium complex that selectively stains nucleoli of cells.
Journal of the American Chemical Society 2006;128(7):2294-9.
2005: David Parker; Junhua Yu
A pH-insensitive, ratiometric chemosensor for citrate using europium luminescence.
Chemical communications (Cambridge, England) 2005;(25):3141-3.
2005: Robert A Poole; Gabriella Bobba; Martin J Cann; Juan-Carlos Frias; David Parker; Robert D Peacock
Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage "in cellulo".
Organic & biomolecular chemistry 2005;3(6):1013-24.
2005: David A Fulton; Mark O'Halloran; David Parker; Kanthi Senanayake; Mauro Botta; Silvio Aime
Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates.
Chemical communications (Cambridge, England) 2005;(4):474-6.
2005: David Parker; Yann Bretonniere
Luminescent lanthanide complexes as sensors and imaging probes.
Ernst Schering Research Foundation workshop 2005;(49):123-46.
2004: Nicola C Thompson; David Parker; Heribert Schmitt-Willich; Detlev Sulzle; Gilles Muller; James P Riehl
NMR and chiroptical examination of the diastereoisomers of (S)-Eu-EOB-DTPA.
Dalton transactions (Cambridge, England : 2003) 2004;(12):1892-5.
2004: Yann Bretonniere; Martin J Cann; David Parker; Rachel Slater
Design, synthesis and evaluation of ratiometric probes for hydrogencarbonate based on europium emission.
Organic & biomolecular chemistry 2004;2(11):1624-32.
2004: Aileen Congreve; David Parker; Eliana Gianolio; Mauro Botta
Steric control of lanthanide hydration state: fast water exchange at gadolinium in a mono-amide 'DOTA' complex.
Dalton transactions (Cambridge, England : 2003) 2004;(9):1441-5.
2004: David Parker
Excitement in f block: structure, dynamics and function of nine-coordinate chiral lanthanide complexes in aqueous media.
Chemical Society reviews 2004;33(3):156-65.
2004: Paul Atkinson; Yann Bretonniere; David Parker
Chemoselective signalling of selected phospho-anions using lanthanide luminescence.
Chemical communications (Cambridge, England) 2004;(4):438-9.
2004: Rachel S Dickins; Andrei S Batsanov; Judith A K Howard; David Parker; Horst Puschmann; Stefania Salamano
Structural and NMR investigations of the ternary adducts of twenty alpha-amino acids and selected dipeptides with a chiral, diaqua-ytterbium complex.
Dalton transactions (Cambridge, England : 2003) 2004;(1):70-80.
2003: David Parker; Horst Puschmann; Andrei S Batsanov; Kanthi Senanayake
Structural analysis of nine-coordinate lanthanide complexes: steric control of the metal-water distance across the series.
Inorganic chemistry 2003;42(26):8646-51.
2003: Alessandro Barge; Mauro Botta; David Parker; Horst Puschmann
The nature of the counter-anion can determine the rate of water exchange in a metal aqua complex.
Chemical communications (Cambridge, England) 2003;(12):1386-7.
2003: Gabriella Bobba; Yann Bretonnière; Juan-Carlos Frias; David Parker
Enantiopure lanthanide complexes incorporating a tetraazatriphenylene sensitiser and three naphthyl groups: exciton coupling, intramolecular energy transfer, efficient singlet oxygen formation and perturbation by DNA binding.
Organic & biomolecular chemistry 2003;1(11):1870-2.
2003: Mauro Botta; Silvio Aime; Alessandro Barge; Gabriella Bobba; Rachel S Dickins; David Parker; Enzo Terreno
Ternary complexes between cationic GdIII chelates and anionic metabolites in aqueous solution: an NMR relaxometric study.
Chemistry (Weinheim an der Bergstrasse, Germany) 2003;9(9):2102-9.
2003: Juan-Carlos Frias; Gabriella Bobba; Martin J Cann; Christopher J Hutchison; David Parker
Luminescent nonacoordinate cationic lanthanide complexes as potential cellular imaging and reactive probes.
Organic & biomolecular chemistry 2003;1(6):905-7.
2003: David Parker; J A Gareth Williams
Responsive luminescent lanthanide complexes.
Metal ions in biological systems 2003;40():233-80.
2002: Rachel S Dickins; Silvio Aime; Andrei S Batsanov; Andrew Beeby; Mauro Botta; James I Bruce; Judith A K Howard; Christine S Love; David Parker; Robert D Peacock; Horst Puschmann
Structural, luminescence, and NMR studies of the reversible binding of acetate, lactate, citrate, and selected amino acids to chiral diaqua ytterbium, gadolinium, and europium complexes.
Journal of the American Chemical Society 2002;124(43):12697-705.
2002: Yann Bretonnière; Martin J Cann; David Parker; Rachel Slater
Ratiometric probes for hydrogencarbonate analysis in intracellular or extracellular environments using europium luminescence.
Chemical communications (Cambridge, England) 2002;(17):1930-1.
2002: James I Bruce; David Parker; Stefan Lopinski; Robert D Peacock
Survey of factors determining the circularly polarised luminescence of macrocyclic lanthanide complexes in solution.
Chirality 2002;14(7):562-7.
2002: David Parker; Rachel S Dickins; Horst Puschmann; Clare Crossland; Judith A K Howard
Being excited by lanthanide coordination complexes: aqua species, chirality, excited-state chemistry, and exchange dynamics.
Chemical reviews 2002;102(6):1977-2010.
2002: Silvio Aime; Alessandro Barge; Andrei S Batsanov; Mauro Botta; Daniela Delli Castelli; Franco Fedeli; Armando Mortillaro; David Parker; Horst Puschmann
Controlling the variation of axial water exchange rates in macrocyclic lanthanide(III) complexes.
Chemical communications (Cambridge, England) 2002;(10):1120-1.
2002: Gabriella Bobba; Juan-Carlos Frias; David Parker
Highly emissive, nine-coordinate enantiopure lanthanide complexes incorporating tetraazatriphenylenes as probes for DNA.
Chemical communications (Cambridge, England) 2002;(8):890-1.
2001: James I Bruce; David Parker; David J Tozer
Experimental assessment of lanthanide ion donor preference: spectroscopic and theoretical dissection of static charge and dynamic polarisation contributions to axial ligation in a C4-symmetric chiral europium complex.
Chemical communications (Cambridge, England) 2001;(21):2250-1.
2001: S Blair; MP Lowe; C E Mathieu; David Parker; P K Senanayake; Ritu Kataky
Narrow-range optical pH sensors based on luminescent europium and terbium complexes immobilized in a sol gel glass.
Inorganic chemistry 2001;40(23):5860-7.
2001: MP Lowe; David Parker; O Reany; Silvio Aime; Mauro Botta; Giancarlo Castellano; Eliana Gianolio; Roberto Pagliarin
pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation.
Journal of the American Chemical Society 2001;123(31):7601-9.
2000: Andrew Beeby; Stanley W Botchway; I M Clarkson; Stephen Faulkner; Anthony Parker; David Parker; J A Gareth Williams
Luminescence imaging microscopy and lifetime mapping using kinetically stable lanthanide(III) complexes.
Journal of photochemistry and photobiology. B, Biology 2000;57(2-3):83-9.
2000: Silvio Aime; Eliana Gianolio; Enzo Terreno; Giovanni B Giovenzana; Roberto Pagliarin; Massimo Sisti; Giovanni Palmisano; Mauro Botta; MP Lowe; David Parker
Ternary Gd(III)L-HSA adducts: evidence for the replacement of inner-sphere water molecules by coordinating groups of the protein. Implications for the design of contrast agents for MRI.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 2000;5(4):488-97.