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Ernest Parker

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Rebecca C Markovitz; Shannon L Meeks; Ernest T Parker; John Healey; Pete Lollar
The diversity of the immune response to the A2 domain of human factor VIII.
Shannon L Meeks; Ernest T Parker; Rachel T Barrow; Courtney L Cox; Bhavya S Doshi; Bagirath Gangadharan; John Healey; Pete Lollar
A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function.
Ryan J Summers; Shannon L Meeks; John Francis Healey; Harrison C Brown; Ernest T Parker; Christine Luise Kempton; Christopher B Doering; Pete Lollar
Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein.

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All Publications

2013: Rebecca C Markovitz; Shannon L Meeks; Ernest T Parker; John Healey; Pete Lollar
The diversity of the immune response to the A2 domain of human factor VIII.
Blood 2013;121(14):2785-95.
2012: Shannon L Meeks; Ernest T Parker; Rachel T Barrow; Courtney L Cox; Bhavya S Doshi; Bagirath Gangadharan; John Healey; Pete Lollar
A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function.
Blood 2012;120(12):2512-20.
2011: Ryan J Summers; Shannon L Meeks; John Francis Healey; Harrison C Brown; Ernest T Parker; Christine Luise Kempton; Christopher B Doering; Pete Lollar
Factor VIII A3 domain substitution N1922S results in hemophilia A due to domain-specific misfolding and hyposecretion of functional protein.
Blood 2011;117(11):3190-8.
2011: H Trent Spencer; Gabriela D. Denning; Richard E Gautney; Boro Dropulic; Andre J Roy; Lajos Baranyi; Bagirath Gangadharan; Ernest T Parker; Pete Lollar; Christopher B Doering
Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII.
Molecular therapy : the journal of the American Society of Gene Therapy 2011;19(2):302-9.
2009: S L Meeks; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Non-classical anti-factor VIII C2 domain antibodies are pathogenic in a murine in vivo bleeding model.
Journal of thrombosis and haemostasis : JTH 2009;7(4):658-64.
2008: Shannon L Meeks; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Nonclassical anti-C2 domain antibodies are present in patients with factor VIII inhibitors.
Blood 2008;112(4):1151-3.
2008: Mamoru Shoji; Aiming Sun; Walter Kisiel; Yang J Lu; Hyunsuk Shim; Bernard E McCarey; Christopher Nichols; Ernest T Parker; jan pohl; Cara A Mosley; Aaron R Alizadeh; Dennis C Liotta; James P Snyder
Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa.
Journal of drug targeting 2008;16(3):185-97.
2007: Shannon L Meeks; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation.
Blood 2007;110(13):4234-42.
2007: Ernest T Parker; Pete Lollar
Contribution of A1 subunit residue Q316 in thrombin-activated factor VIII to A2 subunit dissociation.
Biochemistry 2007;46(34):9737-42.
2007: John Francis Healey; Ernest T Parker; Rachel T Barrow; T J Langley; W R Church; Pete Lollar
The humoral response to human factor VIII in hemophilia A mice.
Journal of thrombosis and haemostasis : JTH 2007;5(3):512-9.
2006: Ernest T Parker; Christopher B Doering; Pete Lollar
A1 subunit-mediated regulation of thrombin-activated factor VIII A2 subunit dissociation.
The Journal of biological chemistry 2006;281(20):13922-30.
2006: Bagirath Gangadharan; Ernest T Parker; Lucienne M Ide; H Trent Spencer; Christopher B Doering
High-level expression of porcine factor VIII from genetically modified bone marrow-derived stem cells.
Blood 2006;107(10):3859-64.
2004: Ernest T Parker; John Francis Healey; Rachel T Barrow; Heather N Craddock; Pete Lollar
Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope.
Blood 2004;104(3):704-10.
2004: Ernest T Parker; Heather N Craddock; Rachel T Barrow; Pete Lollar
Comparative immunogenicity of recombinant B domain-deleted porcine factor VIII and Hyate:C in hemophilia A mice presensitized to human factor VIII.
Journal of thrombosis and haemostasis : JTH 2004;2(4):605-11.
2004: Christopher B Doering; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
Identification of porcine coagulation factor VIII domains responsible for high level expression via enhanced secretion.
The Journal of biological chemistry 2004;279(8):6546-52.
2003: Christopher B Doering; Ernest T Parker; Christopher E Nichols; Pete Lollar
Decreased factor VIII levels during acetaminophen-induced murine fulminant hepatic failure.
Blood 2003;102(5):1743-4.
2003: Ernest T Parker; Pete Lollar
A quantitative measure of the efficacy of factor VIII in hemophilia A mice.
Thrombosis and haemostasis 2003;89(3):480-5.
2002: Christopher B Doering; John Francis Healey; Ernest T Parker; Rachel T Barrow; Pete Lollar
High level expression of recombinant porcine coagulation factor VIII.
The Journal of biological chemistry 2002;277(41):38345-9.
2002: Christopher B Doering; Ernest T Parker; John Francis Healey; Heather N Craddock; Rachel T Barrow; Pete Lollar
Expression and characterization of recombinant murine factor VIII.
Thrombosis and haemostasis 2002;88(3):450-8.
2001: Pete Lollar; John Francis Healey; Rachel T Barrow; Ernest T Parker
Factor VIII inhibitors.
Advances in experimental medicine and biology 2001;489():65-73.
1997: Ernest T Parker; J Pohl; M N Blackburn; Pete Lollar
Subunit structure and function of porcine factor Xa-activated factor VIII.
Biochemistry 1997;36(31):9365-73.