Michael Parker

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Kok W Mei; Scanlon Denis B; Karas John A; Miles Luke A; Tew Deborah J; Parker Michael W; Barnham Kevin J; Hutton Craig A
Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide.
Feil Susanne C; Tang Julian; Hansen Guido; Gorman Michael A; Wiktelius Eric; Stenberg Gun; Parker Michael W
Crystallization and preliminary X-ray analysis of glutathione transferases from cyanobacteria.
McKinstry William J; Polekhina Galina; Diefenbach-Jagger Hannelore; Sato Koh; Onuma Etsuro; Gillespie Matthew T; Martin Thomas J; Parker Michael W
Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment.

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All Publications

2009: Kok W Mei; Scanlon Denis B; Karas John A; Miles Luke A; Tew Deborah J; Parker Michael W; Barnham Kevin J; Hutton Craig A
Solid-phase synthesis of homodimeric peptides: preparation of covalently-linked dimers of amyloid beta peptide.
Chemical communications (Cambridge, England) 2009;(41):6228-30.
2009: Feil Susanne C; Tang Julian; Hansen Guido; Gorman Michael A; Wiktelius Eric; Stenberg Gun; Parker Michael W
Crystallization and preliminary X-ray analysis of glutathione transferases from cyanobacteria.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 5):475-7.
2009: McKinstry William J; Polekhina Galina; Diefenbach-Jagger Hannelore; Sato Koh; Onuma Etsuro; Gillespie Matthew T; Martin Thomas J; Parker Michael W
Crystallization of the receptor-binding domain of parathyroid hormone-related protein in complex with a neutralizing monoclonal antibody Fab fragment.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 4):336-8.
2009: Atkinson Sarah C; Dobson Renwick C J; Newman Janet M; Gorman Michael A; Dogovski Con; Parker Michael W; Perugini Matthew A
Crystallization and preliminary X-ray analysis of dihydrodipicolinate synthase from Clostridium botulinum in the presence of its substrate pyruvate.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 3):253-5.
2009: Voss Jarrod E; Scally Stephen W; Taylor Nicole L; Dogovski Con; Alderton Malcolm R; Hutton Craig A; Gerrard Juliet A; Parker Michael W; Dobson Renwick C J; Perugini Matthew A
Expression, purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Bacillus anthracis in the presence of pyruvate.
Acta crystallographica. Section F, Structural biology and crystallization communications 2009;65(Pt 2):188-91.
2009: Chen Xuebin; Cromer Brett; Webb Timothy I; Yang Zhe; Hantke Janina; Harvey Robert J; Parker Michael W; Lynch Joseph W
Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition.
Neuropharmacology 2009;56(1):318-27.
2008: Albiston Anthony L; Morton Craig J; Ng Hooi Ling; Pham Vi; Yeatman Holly R; Ye Siying; Fernando Ruani N; De Bundel Dimitri; Ascher David B; Mendelsohn Frederick A O; Parker Michael W; Chai Siew Yeen
Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(12):4209-17.
2008: Burgess Benjamin R; Dobson Renwick C J; Bailey Michael F; Atkinson Sarah C; Griffin Michael D W; Jameson Geoffrey B; Parker Michael W; Gerrard Juliet A; Perugini Matthew A
Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen.
The Journal of biological chemistry 2008;283(41):27598-603.
2008: Hansen Guido; Hercus Timothy R; McClure Barbara J; Stomski Frank C; Dottore Mara; Powell Jason; Ramshaw Hayley; Woodcock Joanna M; Xu Yibin; Guthridge Mark; McKinstry William J; Lopez Angel F; Parker Michael W
The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation.
Cell 2008;134(3):496-507.
2008: Hansen Guido; Hercus Timothy R; Xu Yibin; Lopez Angel F; Parker Michael W; McKinstry William J
Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 8):711-4.
2008: Burgess Benjamin R; Dobson Renwick C J; Dogovski Con; Jameson Geoffrey B; Parker Michael W; Perugini Matthew A
Purification, crystallization and preliminary X-ray diffraction studies to near-atomic resolution of dihydrodipicolinate synthase from methicillin-resistant Staphylococcus aureus.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 7):659-61.
2008: Androulakis Steve; Schmidberger Jason; Bate Mark A; DeGori Ross; Beitz Anthony; Keong Cyrus; Cameron Bob; McGowan Sheena; Porter Corrine J; Harrison Andrew; Hunter Jane; Martin Jennifer L; Kobe Bostjan; Dobson Renwick C J; Parker Michael W; Whisstock James C; Gray Joan; Treloar Andrew; Groenewegen David; Dickson Neil; Buckle Ashley M
Federated repositories of X-ray diffraction images.
Acta crystallographica. Section D, Biological crystallography 2008;D64(Pt 7):810-4.
2008: Ye Siying; Chai Siew Yeen; Lew Rebecca A; Ascher David B; Morton Craig J; Parker Michael W; Albiston Anthony L
Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2008;86(3):251-61.
2008: Parker Lorien J; Ciccone Sarah; Italiano Louis C; Primavera Alessandra; Oakley Aaron J; Morton Craig J; Hancock Nancy C; Bello Mario Lo; Parker Michael W
The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.
Journal of molecular biology 2008;380(1):131-44.
2008: Dobson Renwick C J; Atkinson Sarah C; Gorman Michael A; Newman Janet M; Parker Michael W; Perugini Matthew A
The purification, crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase from Clostridium botulinum.
Acta crystallographica. Section F, Structural biology and crystallization communications 2008;64(Pt 3):206-8.
2008: Miles Luke A; Wun Kwok S; Crespi Gabriela A N; Fodero-Tavoletti Michelle T; Galatis Denise; Bagley Christopher J; Beyreuther Konrad; Masters Colin L; Cappai Roberto; McKinstry William J; Barnham Kevin J; Parker Michael W
Amyloid-beta-anti-amyloid-beta complex structure reveals an extended conformation in the immunodominant B-cell epitope.
Journal of molecular biology 2008;377(1):181-92.
2008: Kong Geoffrey K-W; Miles Luke A; Crespi Gabriela A N; Morton Craig J; Ng Hooi Ling; Barnham Kevin J; McKinstry William J; Cappai Roberto; Parker Michael W
Copper binding to the Alzheimer's disease amyloid precursor protein.
European biophysics journal : EBJ 2008;37(3):269-79.
2008: Chai Siew Yeen; Yeatman Holly R; Parker Michael W; Ascher David B; Thompson Philip E; Mulvey Hayley T; Albiston Anthony L
Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase.
BMC neuroscience 2008;9 Suppl 2():S14.
2007: Low Wai Yee; Ng Hooi Ling; Morton Craig J; Parker Michael W; Batterham Philip; Robin Charles
Molecular evolution of glutathione S-transferases in the genus Drosophila.
Genetics 2007;177(3):1363-75.
2007: Cromer Brett A; Gorman Michael A; Hansen Guido; Adams Julian J; Coggan Marjorie; Board Philip G; Parker Michael W
Expression, purification, crystallization and preliminary X-ray diffraction analysis of chloride intracellular channel 2 (CLIC2).
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 11):961-3.
2007: Cromer Brett A; Gorman Michael A; Hansen Guido; Adams Julian J; Coggan Marjorie; Littler Dene R; Brown Louise J; Mazzanti Michele; Breit Samuel N; Curmi Paul M G; Dulhunty Angela F; Board Philip G; Parker Michael W
Structure of the Janus protein human CLIC2.
Journal of molecular biology 2007;374(3):719-31.
2007: Bennetts Brett; Parker Michael W; Cromer Brett A
Inhibition of skeletal muscle ClC-1 chloride channels by low intracellular pH and ATP.
The Journal of biological chemistry 2007;282(45):32780-91.
2007: Kong Geoffrey Kwai-Wai; Adams Julian J; Cappai Roberto; Parker Michael W
Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 10):819-24.
2007: Yang Zhe; Cromer Brett A; Harvey Robert J; Parker Michael W; Lynch Joseph W
A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.
Journal of neurochemistry 2007;103(2):580-9.
2007: Avlani Vimesh A; Gregory Karen J; Morton Craig J; Parker Michael W; Sexton Patrick M; Christopoulos Arthur
Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.
The Journal of biological chemistry 2007;282(35):25677-86.
2007: Rossjohn Jamie; Polekhina Galina; Feil Susanne C; Morton Craig J; Tweten Rodney K; Parker Michael W
Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins.
Journal of molecular biology 2007;367(5):1227-36.
2007: Kong Geoffrey K-W; Adams Julian J; Harris Hugh H; Boas John F; Curtain Cyril C; Galatis Denise; Masters Colin L; Barnham Kevin J; McKinstry William J; Cappai Roberto; Parker Michael W
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
Journal of molecular biology 2007;367(1):148-61.
2007: Yang Zhe; Ney Agnieszka; Cromer Brett A; Ng Hooi-Ling; Parker Michael W; Lynch Joseph W
Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.
Journal of neurochemistry 2007;100(3):758-69.
2006: Hawthorne Rebecca; Cromer Brett A; Ng Hooi-Ling; Parker Michael W; Lynch Joseph W
Molecular determinants of ginkgolide binding in the glycine receptor pore.
Journal of neurochemistry 2006;98(2):395-407.
2006: Li Rong; Soosairajah Juliana; Harari Daniel; Citri Ami; Price John; Ng Hooi Ling; Morton Craig J; Parker Michael W; Yarden Yosef; Bernard Ora
Hsp90 increases LIM kinase activity by promoting its homo-dimerization.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1218-20.
2006: Téllez-Sanz Ramiro; Cesareo Eleonora; Nuccetelli Marzia; Aguilera Ana M; Barón Carmen; Parker Lorien J; Adams Julian J; Morton Craig J; Lo Bello Mario; Parker Michael W; García-Fuentes Luis
Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1.
Protein science : a publication of the Protein Society 2006;15(5):1093-105.
2006: House Colin M; Hancock Nancy C; Möller Andreas; Cromer Brett A; Fedorov Victor; Bowtell David D L; Parker Michael W; Polekhina Galina
Elucidation of the substrate binding site of Siah ubiquitin ligase.
Structure (London, England : 1993) 2006;14(4):695-701.
2006: Gralle Matthias; Oliveira Cristiano L P; Guerreiro Luiz H; McKinstry William J; Galatis Denise; Masters Colin L; Cappai Roberto; Parker Michael W; Ramos Carlos H I; Torriani Iris; Ferreira Sérgio T
Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human amyloid precursor protein.
Journal of molecular biology 2006;357(2):493-508.
2006: Andersen Olav M; Schmidt Vanessa; Spoelgen Robert; Gliemann Jørgen; Behlke Joachim; Galatis Denise; McKinstry William J; Parker Michael W; Masters Colin L; Hyman Bradley T; Cappai Roberto; Willnow Thomas E
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Biochemistry 2006;45(8):2618-28.
2005: Cesareo Eleonora; Parker Lorien J; Pedersen Jens Z; Nuccetelli Marzia; Mazzetti Anna P; Pastore Anna; Federici Giorgio; Caccuri Anna M; Ricci Giorgio; Adams Julian J; Parker Michael W; Lo Bello Mario
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo.
The Journal of biological chemistry 2005;280(51):42172-80.
2005: Polekhina Galina; Gupta Abhilasha; van Denderen Bryce J W; Feil Susanne C; Kemp Bruce E; Stapleton David; Parker Michael W
Structural basis for glycogen recognition by AMP-activated protein kinase.
Structure (London, England : 1993) 2005;13(10):1453-62.
2005: Brown Richard J; Adams Julian J; Pelekanos Rebecca A; Wan Yu; McKinstry William J; Palethorpe Kathryn; Seeber Ruth M; Monks Thea A; Eidne Karin A; Parker Michael W; Waters Michael J
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer.
Nature structural & molecular biology 2005;12(9):814-21.
2005: Bennetts Brett; Rychkov Grigori Y; Ng Hooi-Ling; Morton Craig J; Stapleton David; Parker Michael W; Cromer Brett A
Cytoplasmic ATP-sensing domains regulate gating of skeletal muscle ClC-1 chloride channels.
The Journal of biological chemistry 2005;280(37):32452-8.
2005: Pham Vi; Dong Maoqing; Wade John D; Miller Laurence J; Morton Craig J; Ng Hooi-Ling; Parker Michael W; Sexton Patrick M
Insights into interactions between the alpha-helical region of the salmon calcitonin antagonists and the human calcitonin receptor using photoaffinity labeling.
The Journal of biological chemistry 2005;280(31):28610-22.
2005: Parker Michael W; Feil Susanne C
Pore-forming protein toxins: from structure to function.
Progress in biophysics and molecular biology 2005;88(1):91-142.
2005: Kong Geoffrey K-W; Galatis Denise; Barnham Kevin J; Polekhina Galina; Adams Julian J; Masters Colin L; Cappai Roberto; Parker Michael W; McKinstry William J
Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 1):93-5.
2005: Polekhina Galina; Feil Susanne C; Gupta Abhilasha; O'Donnell Paul; Stapleton David; Parker Michael W
Crystallization of the glycogen-binding domain of the AMP-activated protein kinase beta subunit and preliminary X-ray analysis.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 1):39-42.
2005: Polekhina Galina; Giddings Kara Sue; Tweten Rodney K; Parker Michael W
Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(3):600-5.
2004: McKinstry William J; Wan Yu; Adams Julian J; Brown Richard J; Waters Michael J; Parker Michael W
Crystallization and preliminary X-ray diffraction analysis of the unliganded human growth hormone receptor.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 12 Pt 2):2380-2.
2004: Austin Christopher J D; Mizdrak Jasminka; Matin Azadeh; Sirijovski Nicholche; Kosim-Satyaputra Priambudi; Willows Robert D; Roberts Thomas H; Truscott Roger J W; Polekhina Galina; Parker Michael W; Jamie Joanne F
Optimised expression and purification of recombinant human indoleamine 2,3-dioxygenase.
Protein expression and purification 2004;37(2):392-8.
2004: Ricci Giorgio; Turella Paola; De Maria Francesca; Antonini Giovanni; Nardocci Luisa; Board Philip G; Parker Michael W; Carbonelli Maria Grazia; Federici Giorgio; Caccuri Anna Maria
Binding and kinetic mechanisms of the Zeta class glutathione transferase.
The Journal of biological chemistry 2004;279(32):33336-42.
2004: Melton Jody A; Parker Michael W; Rossjohn Jamie; Buckley J Thomas; Tweten Rodney K
The identification and structure of the membrane-spanning domain of the Clostridium septicum alpha toxin.
The Journal of biological chemistry 2004;279(14):14315-22.
2004: Polekhina Galina; Giddings Kara Sue; Tweten Rodney K; Parker Michael W
Crystallization and preliminary X-ray analysis of the human-specific toxin intermedilysin.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):347-9.
2004: Adams Julian; Chen Zhi-Ping; Van Denderen Bryce J W; Morton Craig J; Parker Michael W; Witters Lee A; Stapleton David; Kemp Bruce E
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site.
Protein science : a publication of the Protein Society 2004;13(1):155-65.
2003: Ortiz-Salmerón Emilia; Nuccetelli Marzia; Oakley Aaron J; Parker Michael W; Lo Bello Mario; García-Fuentes Luis
Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1-1 in binding with glutathione and the inhibitor S-hexylglutathione.
The Journal of biological chemistry 2003;278(47):46938-48.
2003: Ricci Giorgio; Caccuri Anna Maria; Lo Bello Mario; Parker Michael W; Nuccetelli Marzia; Turella Paola; Stella Lorenzo; Di Iorio Ernesto E; Federici Giorgio
Glutathione transferase P1-1: self-preservation of an anti-cancer enzyme.
The Biochemical journal 2003;376(Pt 1):71-6.
2003: Board Philip G; Taylor Matthew C; Coggan Marjorie; Parker Michael W; Lantum Hoffman B; Anders M W
Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique.
The Biochemical journal 2003;374(Pt 3):731-7.
2003: Nevin Simon T; Cromer Brett A; Haddrill Justine L; Morton Craig J; Parker Michael W; Lynch Joseph W
Insights into the structural basis for zinc inhibition of the glycine receptor.
The Journal of biological chemistry 2003;278(31):28985-92.
2003: Parker Michael W
Cryptic clues as to how water-soluble protein toxins form pores in membranes.
Toxicon : official journal of the International Society on Toxinology 2003;42(1):1-6.
2003: Lin Henry J; Johansson Ann Sofie; Stenberg Gun; Materi Alicia M; Park Jae Man; Dai Aihua; Zhou Haiyan; Gim Jason S Y; Kau Irving H; Hardy Steven I; Parker Michael W; Mannervik Bengt
Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1.
Biochimica et biophysica acta 2003;1649(1):16-23.
2003: Polekhina Galina; Gupta Abhilasha; Michell Belinda J; van Denderen Bryce; Murthy Sid; Feil Susanne C; Jennings Ian G; Campbell Duncan J; Witters Lee A; Parker Michael W; Kemp Bruce E; Stapleton David
AMPK beta subunit targets metabolic stress sensing to glycogen.
Current biology : CB 2003;13(10):867-71.
2003: Barnham Kevin J; McKinstry William J; Multhaup Gerd; Galatis Denise; Morton Craig J; Curtain Cyril C; Williamson Nicholas A; White Anthony R; Hinds Mark G; Norton Raymond S; Beyreuther Konrad; Masters Colin L; Parker Michael W; Cappai Roberto
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis.
The Journal of biological chemistry 2003;278(19):17401-7.
2003: Micaloni Chiara; Kong Geoffrey K-W; Mazzetti Anna P; Nuccetelli Marzia; Antonini Giovanni; Stella Lorenzo; McKinstry William J; Polekhina Galina; Rossjohn Jamie; Federici Giorgio; Ricci Giorgio; Parker Michael W; Lo Bello Mario
Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences.
Journal of molecular biology 2003;325(1):111-22.
2003: Kong Geoffrey K-W; Polekhina Galina; McKinstry William J; Parker Michael W; Dragani Beatrice; Aceto Antonio; Paludi Domenico; Principe Daniela Rossi; Mannervik Bengt; Stenberg Gun
Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1.
The Journal of biological chemistry 2003;278(2):1291-302.
2002: Bowser David N; Wagner David A; Czajkowski Cynthia; Cromer Brett A; Parker Michael W; Wallace Robyn H; Harkin Louise A; Mulley John C; Marini Carla; Berkovic Samuel F; Williams David A; Jones Mathew V; Petrou Steven
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15170-5.
2002: Cromer Brett A; Morton Craig J; Board Philip G; Parker Michael W
From glutathione transferase to pore in a CLIC.
European biophysics journal : EBJ 2002;31(5):356-64.
2002: Coggan Marjorie; Flanagan Jack U; Parker Michael W; Vichai Vanicha; Pearson William R; Board Philip G
Identification and characterization of GSTT3, a third murine Theta class glutathione transferase.
The Biochemical journal 2002;366(Pt 1):323-32.
2002: Cromer Brett A; Morton Craig J; Parker Michael W
Anxiety over GABA(A) receptor structure relieved by AChBP.
Trends in biochemical sciences 2002;27(6):280-7.
2002: Farrow Kylie A; Lyras Dena; Polekhina Galina; Koutsis Katerina; Parker Michael W; Rood Julian I
Identification of essential residues in the Erm(B) rRNA methyltransferase of Clostridium perfringens.
Antimicrobial agents and chemotherapy 2002;46(5):1253-61.
2002: Caccuri Anna Maria; Antonini Giovanni; Allocati Nerino; Di Ilio Carmine; De Maria Francesca; Innocenti Federica; Parker Michael W; Masulli Michele; Lo Bello Mario; Turella Paola; Federici Giorgio; Ricci Giorgio
GSTB1-1 from Proteus mirabilis: a snapshot of an enzyme in the evolutionary pathway from a redox enzyme to a conjugating enzyme.
The Journal of biological chemistry 2002;277(21):18777-84.
2002: Caccuri Anna Maria; Antonini Giovanni; Allocati Nerino; Di Ilio Carmine; Innocenti Federica; De Maria Francesca; Parker Michael W; Masulli Michele; Polizio Francesca; Federici Giorgio; Ricci Giorgio
Properties and utility of the peculiar mixed disulfide in the bacterial glutathione transferase B1-1.
Biochemistry 2002;41(14):4686-93.
2002: Allocati Nerino; Masulli Michele; Casalone Enrico; Santucci Silvia; Favaloro Bartolo; Parker Michael W; Di Ilio Carmine
Glutamic acid-65 is an essential residue for catalysis in Proteus mirabilis glutathione S-transferase B1-1.
The Biochemical journal 2002;363(Pt 1):189-93.
2002: White Anthony R; Multhaup Gerd; Galatis Denise; McKinstry William J; Parker Michael W; Pipkorn Rüdiger; Beyreuther Konrad; Masters Colin L; Cappai Roberto
Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(2):365-76.
2002: Polekhina Galina; House Colin M; Traficante Nadia; Mackay Joel P; Relaix Frédéric; Sassoon David A; Parker Michael W; Bowtell David D L
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.
Nature structural biology 2002;9(1):68-75.
2001: Blackburn A C; Coggan M; Tzeng H F; Lantum H; Polekhina G; Parker M W; Anders M W; Board P G
GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase.
Pharmacogenetics 2001;11(8):671-8.
2001: Lo Bello M; Nuccetelli M; Caccuri A M; Stella L; Parker M W; Rossjohn J; McKinstry W J; Mozzi A F; Federici G; Polizio F; Pedersen J Z; Ricci G
Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme.
The Journal of biological chemistry 2001;276(45):42138-45.
2001: Gisi D; Maillard J; Flanagan J U; Rossjohn J; Chelvanayagam G; Board P G; Parker M W; Leisinger T; Vuilleumier S
Dichloromethane mediated in vivo selection and functional characterization of rat glutathione S-transferase theta 1-1 variants.
European journal of biochemistry / FEBS 2001;268(14):4001-10.
2001: Hotze E M; Wilson-Kubalek E M; Rossjohn J; Parker M W; Johnson A E; Tweten R K
Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane beta-sheet from a prepore intermediate.
The Journal of biological chemistry 2001;276(11):8261-8.
2001: Polekhina G; Board P G; Blackburn A C; Parker M W
Crystal structure of maleylacetoacetate isomerase/glutathione transferase zeta reveals the molecular basis for its remarkable catalytic promiscuity.
Biochemistry 2001;40(6):1567-76.
2001: Caccuri A M; Antonini G; Board P G; Flanagan J; Parker M W; Paolesse R; Turella P; Federici G; Lo Bello M; Ricci G
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of substrate binding to the active site of glutathione transferases.
The Journal of biological chemistry 2001;276(8):5427-31.
2001: Caccuri A M; Antonini G; Board P G; Flanagan J; Parker M W; Paolesse R; Turella P; Chelvanayagam G; Ricci G
Human glutathione transferase T2-2 discloses some evolutionary strategies for optimization of the catalytic activity of glutathione transferases.
The Journal of biological chemistry 2001;276(8):5432-7.
2001: Tweten R K; Parker M W; Johnson A E
The cholesterol-dependent cytolysins.
Current topics in microbiology and immunology 2001;257():15-33.
2000: Micaloni C; Mazzetti A P; Nuccetelli M; Rossjohn J; McKinstry W J; Antonini G; Caccuri A M; Oakley A J; Federici G; Ricci G; Parker M W; Lo Bello M
Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1.
Biochemistry 2000;39(51):15961-70.
2000: Allocati N; Casalone E; Masulli M; Polekhina G; Rossjohn J; Parker M W; Di Ilio C
Evaluation of the role of two conserved active-site residues in beta class glutathione S-transferases.
The Biochemical journal 2000;351 Pt 2():341-6.
2000: Rossjohn J; McKinstry W J; Oakley A J; Parker M W; Stenberg G; Mannervik B; Dragani B; Cocco R; Aceto A
Structures of thermolabile mutants of human glutathione transferase P1-1.
Journal of molecular biology 2000;302(2):295-302.
2000: Njålsson R; Carlsson K; Olin B; Carlsson B; Whitbread L; Polekhina G; Parker M W; Norgren S; Mannervik B; Board P G; Larsson A
Kinetic properties of missense mutations in patients with glutathione synthetase deficiency.
The Biochemical journal 2000;349(Pt 1):275-9.
2000: Flanagan J U; King W; Parker M W; Board P G; Chelvanayagam G
Ab initio calculations on hidden modulators of theta class glutathione transferase activity.
Proteins 2000;39(3):235-43.
2000: Rossjohn J; McKinstry W J; Woodcock J M; McClure B J; Hercus T R; Parker M W; Lopez A F; Bagley C J
Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist.
Blood 2000;95(8):2491-8.
2000: Dunstone M A; Dai W; Whisstock J C; Rossjohn J; Pike R N; Feil S C; Le Bonniec B F; Parker M W; Bottomley S P
Cleaved antitrypsin polymers at atomic resolution.
Protein science : a publication of the Protein Society 2000;9(2):417-20.
1999: Caccuri A M; Antonini G; Board P G; Parker M W; Nicotra M; Lo Bello M; Federici G; Ricci G
Proton release on binding of glutathione to alpha, Mu and Delta class glutathione transferases.
The Biochemical journal 1999;344 Pt 2():419-25.
1999: Gilbert R J; Heenan R K; Timmins P A; Gingles N A; Mitchell T J; Rowe A J; Rossjohn J; Parker M W; Andrew P W; Byron O
Studies on the structure and mechanism of a bacterial protein toxin by analytical ultracentrifugation and small-angle neutron scattering.
Journal of molecular biology 1999;293(5):1145-60.
1999: Shatursky O; Heuck A P; Shepard L A; Rossjohn J; Parker M W; Johnson A E; Tweten R K
The mechanism of membrane insertion for a cholesterol-dependent cytolysin: a novel paradigm for pore-forming toxins.
Cell 1999;99(3):293-9.
1999: Flanagan J U; Rossjohn J; Parker M W; Board P G; Chelvanayagam G
Mutagenic analysis of conserved arginine residues in and around the novel sulfate binding pocket of the human Theta class glutathione transferase T2-2.
Protein science : a publication of the Protein Society 1999;8(10):2205-12.
1999: Oakley A J; Lo Bello M; Nuccetelli M; Mazzetti A P; Parker M W
The ligandin (non-substrate) binding site of human Pi class glutathione transferase is located in the electrophile binding site (H-site).
Journal of molecular biology 1999;291(4):913-26.
1999: Polekhina G; Board P G; Gali R R; Rossjohn J; Parker M W
Molecular basis of glutathione synthetase deficiency and a rare gene permutation event.
The EMBO journal 1999;18(12):3204-13.
1999: Rossjohn J; Cappai R; Feil S C; Henry A; McKinstry W J; Galatis D; Hesse L; Multhaup G; Beyreuther K; Masters C L; Parker M W
Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.
Nature structural biology 1999;6(4):327-31.
1999: Allocati N; Casalone E; Masulli M; Ceccarelli I; Carletti E; Parker M W; Di Ilio C
Functional analysis of the evolutionarily conserved proline 53 residue in Proteus mirabilis glutathione transferase B1-1.
FEBS letters 1999;445(2-3):347-50.
1998: Lo Bello M; Nuccetelli M; Chiessi E; Lahm A; Mazzetti A P; Battistoni A; Caccuri A M; Oakley A J; Parker M W; Tramontano A; Federici G; Ricci G
Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.
Journal of molecular biology 1998;284(5):1717-25.
1998: Gilbert R J; Rossjohn J; Parker M W; Tweten R K; Morgan P J; Mitchell T J; Errington N; Rowe A J; Andrew P W; Byron O
Self-interaction of pneumolysin, the pore-forming protein toxin of Streptococcus pneumoniae.
Journal of molecular biology 1998;284(4):1223-37.
1998: Flanagan J U; Rossjohn J; Parker M W; Board P G; Chelvanayagam G
A homology model for the human theta-class glutathione transferase T1-1.
Proteins 1998;33(3):444-54.
1998: Nuccetelli M; Mazzetti A P; Rossjohn J; Parker M W; Board P; Caccuri A M; Federici G; Ricci G; Lo Bello M
Shifting substrate specificity of human glutathione transferase (from class Pi to class alpha) by a single point mutation.
Biochemical and biophysical research communications 1998;252(1):184-9.
1998: Rossjohn J; Gilbert R J; Crane D; Morgan P J; Mitchell T J; Rowe A J; Andrew P W; Paton J C; Tweten R K; Parker M W
The molecular mechanism of pneumolysin, a virulence factor from Streptococcus pneumoniae.
Journal of molecular biology 1998;284(2):449-61.
1998: Shepard L A; Heuck A P; Hamman B D; Rossjohn J; Parker M W; Ryan K R; Johnson A E; Tweten R K
Identification of a membrane-spanning domain of the thiol-activated pore-forming toxin Clostridium perfringens perfringolysin O: an alpha-helical to beta-sheet transition identified by fluorescence spectroscopy.
Biochemistry 1998;37(41):14563-74.
1998: Vetter I R; Parker M W; Tucker A D; Lakey J H; Pattus F; Tsernoglou D
Crystal structure of a colicin N fragment suggests a model for toxicity.
Structure (London, England : 1993) 1998;6(7):863-74.
1998: Oakley A J; Lo Bello M; Ricci G; Federici G; Parker M W
Evidence for an induced-fit mechanism operating in pi class glutathione transferases.
Biochemistry 1998;37(28):9912-7.
1998: Rossjohn J; Polekhina G; Feil S C; Allocati N; Masulli M; De Illio C; Parker M W
A mixed disulfide bond in bacterial glutathione transferase: functional and evolutionary implications.
Structure (London, England : 1993) 1998;6(6):721-34.
1998: Rossjohn J; McKinstry W J; Oakley A J; Verger D; Flanagan J; Chelvanayagam G; Tan K L; Board P G; Parker M W
Human theta class glutathione transferase: the crystal structure reveals a sulfate-binding pocket within a buried active site.
Structure (London, England : 1993) 1998;6(3):309-22.
1998: Nicotra M; Paci M; Sette M; Oakley A J; Parker M W; Lo Bello M; Caccuri A M; Federici G; Ricci G
Solution structure of glutathione bound to human glutathione transferase P1-1: comparison of NMR measurements with the crystal structure.
Biochemistry 1998;37(9):3020-7.
1998: Casalone E; Allocati N; Ceccarelli I; Masulli M; Rossjohn J; Parker M W; Di Ilio C
Site-directed mutagenesis of the Proteus mirabilis glutathione transferase B1-1 G-site.
FEBS letters 1998;423(2):122-4.
1998: McKinstry W J; Oakley A J; Rossjohn J; Verger D; Tan K L; Board P G; Parker M W
Preliminary X-ray crystallographic studies of a newly defined human theta-class glutathione transferase.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 1):148-50.
1998: Rossjohn J; Raja S M; Nelson K L; Feil S C; van der Goot F G; Parker M W; Buckley J T
Movement of a loop in domain 3 of aerolysin is required for channel formation.
Biochemistry 1998;37(2):741-6.
1998: Rossjohn J; Feil S C; McKinstry W J; Tsernoglou D; van der Goot G; Buckley J T; Parker M W
Aerolysin--a paradigm for membrane insertion of beta-sheet protein toxins?
Journal of structural biology 1998;121(2):92-100.
1997: Oakley A J; Lo Bello M; Mazzetti A P; Federici G; Parker M W
The glutathione conjugate of ethacrynic acid can bind to human pi class glutathione transferase P1-1 in two different modes.
FEBS letters 1997;419(1):32-6.
1997: Cabiaux V; Buckley J T; Wattiez R; Ruysschaert J M; Parker M W; van der Goot F G
Conformational changes in aerolysin during the transition from the water-soluble protoxin to the membrane channel.
Biochemistry 1997;36(49):15224-32.
1997: Oakley A J; Lo Bello M; Battistoni A; Ricci G; Rossjohn J; Villar H O; Parker M W
The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution.
Journal of molecular biology 1997;274(1):84-100.
1997: Caccuri A M; Antonini G; Nicotra M; Battistoni A; Lo Bello M; Board P G; Parker M W; Ricci G
Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione S-transferases. Investigation of Ser-9 and Tyr-113 in a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.
The Journal of biological chemistry 1997;272(47):29681-6.
1997: Rossjohn J; Feil S C; Wilce M C; Sexton J L; Spithill T W; Parker M W
Crystallization, structural determination and analysis of a novel parasite vaccine candidate: Fasciola hepatica glutathione S-transferase.
Journal of molecular biology 1997;273(4):857-72.
1997: Rossjohn J; Buckley J T; Hazes B; Murzin A G; Read R J; Parker M W
Aerolysin and pertussis toxin share a common receptor-binding domain.
The EMBO journal 1997;16(12):3426-34.
1997: Kobe B; Jennings I G; House C M; Feil S C; Michell B J; Tiganis T; Parker M W; Cotton R G; Kemp B E
Regulation and crystallization of phosphorylated and dephosphorylated forms of truncated dimeric phenylalanine hydroxylase.
Protein science : a publication of the Protein Society 1997;6(6):1352-7.
1997: Rossjohn J; Feil S C; McKinstry W J; Tweten R K; Parker M W
Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form.
Cell 1997;89(5):685-92.
1997: Lo Bello M; Oakley A J; Battistoni A; Mazzetti A P; Nuccetelli M; Mazzarese G; Rossjohn J; Parker M W; Ricci G
Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.
Biochemistry 1997;36(20):6207-17.
1997: Chelvanayagam G; Wilce M C; Parker M W; Tan K L; Board P G
Homology model for the human GSTT2 Theta class glutathione transferase.
Proteins 1997;27(1):118-30.
1997: Oakley A J; Rossjohn J; Lo Bello M; Caccuri A M; Federici G; Parker M W
The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate.
Biochemistry 1997;36(3):576-85.
1996: Kobe B; Heierhorst J; Feil S C; Parker M W; Benian G M; Weiss K R; Kemp B E
Giant protein kinases: domain interactions and structural basis of autoregulation.
The EMBO journal 1996;15(24):6810-21.
1996: Feil S C; Rossjohn J; Rohde K; Tweten R K; Parker M W
Crystallization and preliminary X-ray analysis of a thiol-activated cytolysin.
FEBS letters 1996;397(2-3):290-2.
1996: Tan K L; Chelvanayagam G; Parker M W; Board P G
Mutagenesis of the active site of the human Theta-class glutathione transferase GSTT2-2: catalysis with different substrates involves different residues.
The Biochemical journal 1996;319 ( Pt 1)():315-21.
1996: Caccuri A M; Ascenzi P; Antonini G; Parker M W; Oakley A J; Chiessi E; Nuccetelli M; Battistoni A; Bellizia A; Ricci G
Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase.
The Journal of biological chemistry 1996;271(27):16193-8.
1996: Rossjohn J; Board P G; Parker M W; Wilce M C
A structurally derived consensus pattern for theta class glutathione transferases.
Protein engineering 1996;9(4):327-32.
1996: Heierhorst J; Kobe B; Feil S C; Parker M W; Benian G M; Weiss K R; Kemp B E
Ca2+/S100 regulation of giant protein kinases.
Nature 1996;380(6575):636-9.
1996: Feil S C; Wilce M C; Rossjohn J; Allocati N; Aceto A; Di Ilio C; Parker M W
Crystallization and preliminary X-ray analysis of a bacterial glutathione transferase.
Acta crystallographica. Section D, Biological crystallography 1996;52(Pt 1):189-91.
1996: Parker M W; van der Goot F G; Buckley J T
Aerolysin--the ins and outs of a model channel-forming toxin.
Molecular microbiology 1996;19(2):205-12.
1996: Kemp B E; Barden J A; Kobe B; House C; Parker M W
Intrasteric regulation of calmodulin-dependent protein kinases.
Advances in pharmacology (San Diego, Calif.) 1996;36():221-49.
1995: Buckley J T; Wilmsen H U; Lesieur C; Schulze A; Pattus F; Parker M W; van der Goot F G
Protonation of histidine-132 promotes oligomerization of the channel-forming toxin aerolysin.
Biochemistry 1995;34(50):16450-5.
1995: Board P G; Coggan M; Wilce M C; Parker M W
Evidence for an essential serine residue in the active site of the Theta class glutathione transferases.
The Biochemical journal 1995;311 ( Pt 1)():247-50.
1995: Hardie K R; Schulze A; Parker M W; Buckley J T
Vibrio spp. secrete proaerolysin as a folded dimer without the need for disulphide bond formation.
Molecular microbiology 1995;17(6):1035-44.
1995: Wilce M C; Board P G; Feil S C; Parker M W
Crystal structure of a theta-class glutathione transferase.
The EMBO journal 1995;14(10):2133-43.
1995: Ricci G; Lo Bello M; Caccurri A M; Pastore A; Nuccetelli M; Parker M W; Federici G
Site-directed mutagenesis of human glutathione transferase P1-1. Mutation of Cys-47 induces a positive cooperatively in glutathione transferase P1-1.
The Journal of biological chemistry 1995;270(3):1243-8.
1994: Kemp B E; Parker M W; Hu S; Tiganis T; House C
Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity.
Trends in biochemical sciences 1994;19(11):440-4.
1994: Hu S H; Parker M W; Lei J Y; Wilce M C; Benian G M; Kemp B E
Insights into autoregulation from the crystal structure of twitchin kinase.
Nature 1994;369(6481):581-4.
1994: Wilce M C; Parker M W
Structure and function of glutathione S-transferases.
Biochimica et biophysica acta 1994;1205(1):1-18.
1994: Wilce M C; Feil S C; Board P G; Parker M W
Crystallization and preliminary X-ray diffraction studies of a glutathione S-transferase from the Australian sheep blowfly, Lucilia cuprina.
Journal of molecular biology 1994;236(5):1407-9.
1994: Hu S H; Lei J Y; Wilce M C; Valenzuela M R; Benian G M; Parker M W; Kemp B E
Crystallization and preliminary X-ray analysis of the auto-inhibited twitchin kinase.
Journal of molecular biology 1994;236(4):1259-61.
1994: Sexton J L; Wilce M C; Colin T; Wijffels G L; Salvatore L; Feil S; Parker M W; Spithill T W; Morrison C A
Vaccination of sheep against Fasciola hepatica with glutathione S-transferase. Identification and mapping of antibody epitopes on a three-dimensional model of the antigen.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1861-72.
1994: Parker M W; Buckley J T; Postma J P; Tucker A D; Leonard K; Pattus F; Tsernoglou D
Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states.
Nature 1994;367(6460):292-5.
1993: Parker M W; Pattus F
Rendering a membrane protein soluble in water: a common packing motif in bacterial protein toxins.
Trends in biochemical sciences 1993;18(10):391-5.
1993: Lo Bello M; Parker M W; Desideri A; Polticelli F; Falconi M; Del Boccio G; Pennelli A; Federici G; Ricci G
Peculiar spectroscopic and kinetic properties of Cys-47 in human placental glutathione transferase. Evidence for an atypical thiolate ion pair near the active site.
The Journal of biological chemistry 1993;268(25):19033-8.
1993: Lo Bello M; Pastore A; Petruzzelli R; Parker M W; Wilce M C; Federici G; Ricci G
Conformational states of human placental glutathione transferase as probed by limited proteolysis.
Biochemical and biophysical research communications 1993;194(2):804-10.
1992: Parker M W; Postma J P; Pattus F; Tucker A D; Tsernoglou D
Refined structure of the pore-forming domain of colicin A at 2.4 A resolution.
Journal of molecular biology 1992;224(3):639-57.
1991: Tucker A D; Jackman S; Parker M W; Tsernoglou D
Crystallization and preliminary X-ray analysis of phosphoporin from the outer membrane of Escherichia coli.
Journal of molecular biology 1991;222(4):881-4.
1991: Pauptit R A; Schirmer T; Jansonius J N; Rosenbusch J P; Parker M W; Tucker A D; Tsernoglou D; Weiss M S; Schultz G E
A common channel-forming motif in evolutionarily distant porins.
Journal of structural biology 1991;107(2):136-45.
1991: Lakey J H; Massotte D; Heitz F; Dasseux J L; Faucon J F; Parker M W; Pattus F
Membrane insertion of the pore-forming domain of colicin A. A spectroscopic study.
European journal of biochemistry / FEBS 1991;196(3):599-607.
1990: Parker M W; Lo Bello M; Federici G
Crystallization of glutathione S-transferase from human placenta.
Journal of molecular biology 1990;213(2):221-2.
1990: Tucker A D; Parker M W; Tsernoglou D; Buckley J T
Crystallization of a proform of aerolysin, a hole-forming toxin from Aeromonas hydrophila.
Journal of molecular biology 1990;212(4):561-2.
1990: Parker M W; Tucker A D; Tsernoglou D; Pattus F
Insights into membrane insertion based on studies of colicins.
Trends in biochemical sciences 1990;15(4):126-9.
1990: Pattus F; Massotte D; Wilmsen H U; Lakey J; Tsernoglou D; Tucker A; Parker M W
Colicins: prokaryotic killer-pores.
Experientia 1990;46(2):180-92.
1989: Postma J P; Parker M W; Tsernoglou D
Application of molecular dynamics in the crystallographic refinement of colicin A.
Acta crystallographica. Section A, Foundations of crystallography 1989;45 ( Pt 7)():471-7.
1989: Tucker A D; Baty D; Parker M W; Pattus F; Lazdunski C; Tsernoglou D
Crystallographic phases through genetic engineering: experiences with colicin A.
Protein engineering 1989;2(6):399-405.
1989: Parker M W; Pattus F; Tucker A D; Tsernoglou D
Structure of the membrane-pore-forming fragment of colicin A.
Nature 1989;337(6202):93-6.
1988: Parker M W; Blake C C
Iron- and manganese-containing superoxide dismutases can be distinguished by analysis of their primary structures.
FEBS letters 1988;229(2):377-82.

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