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Peter Parker

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
13
Woscholski, R
10
Dekker, Lodewijk
9
Waterfield, Michael
8
Larijani, Banafshé
7
Cooke, Frank
7
Dove, Stephen
6
Calleja, Véronique
6
Whelan, Richard
6
Michell, Robert
5
Totty, Nick
5
Sugden, Peter
5
Evans, FJ
5
Jaken, S
5
Mellor, H
4
Kermorgant, Stéphanie

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Publications

TOP 3
Rosse Carine; Formstecher Etienne; Boeckeler Katrina; Zhao Yingming; Kremerskothen Joachim; White Michael D; Camonis Jacques H; Parker Peter J
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation.
Kostelecky Brenda; Saurin Adrian T; Purkiss Andrew; Parker Peter J; McDonald Neil Q
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.
De Rycker Manu; Rigoreau Laurent; Dowding Sarah; Parker Peter J
A high-content, cell-based screen identifies micropolyin, a new inhibitor of microtubule dynamics.

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All Publications

2009: Rosse Carine; Formstecher Etienne; Boeckeler Katrina; Zhao Yingming; Kremerskothen Joachim; White Michael D; Camonis Jacques H; Parker Peter J
An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation.
PLoS biology 2009;7(11):e1000235.
2009: Kostelecky Brenda; Saurin Adrian T; Purkiss Andrew; Parker Peter J; McDonald Neil Q
Recognition of an intra-chain tandem 14-3-3 binding site within PKCepsilon.
EMBO reports 2009;10(9):983-9.
2009: De Rycker Manu; Rigoreau Laurent; Dowding Sarah; Parker Peter J
A high-content, cell-based screen identifies micropolyin, a new inhibitor of microtubule dynamics.
Chemical biology & drug design 2009;73(6):599-610.
2009: Cameron Angus J M; Escribano Cristina; Saurin Adrian T; Kostelecky Brenda; Parker Peter J
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.
Nature structural & molecular biology 2009;16(6):624-30.
2009: Saurin Adrian T; Brownlow Nicola; Parker Peter J
Protein kinase C epsilon in cell division: control of abscission.
Cell cycle (Georgetown, Tex.) 2009;8(4):549-55.
2008: Kermorgant Stéphanie; Parker Peter J
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation.
The Journal of cell biology 2008;182(5):855-63.
2008: Cameron Angus J; Procyk Katarzyna J; Leitges Michael; Parker Peter J
PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival.
International journal of cancer. Journal international du cancer 2008;123(4):769-79.
2008: Kong Anthony; Calleja Véronique; Leboucher Pierre; Harris Adrian; Parker Peter J; Larijani Banafshé
HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells.
PloS one 2008;3(8):e2881.
2007: Cameron A J; De Rycker M; Calleja V; Alcor D; Kjaer S; Kostelecky B; Saurin A; Faisal A; Laguerre M; Hemmings B A; McDonald N; Larijani B; Parker P J
Protein kinases, from B to C.
Biochemical Society transactions 2007;35(Pt 5):1013-7.
2007: Calleja Véronique; Alcor Damien; Laguerre Michel; Park Jongsun; Vojnovic Borivoj; Hemmings Brian A; Downward Julian; Parker Peter J; Larijani Banafshé
Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.
PLoS biology 2007;5(4):e95.
2007: Iturrioz Xavier; Parker Peter J
PKCzetaII is a target for degradation through the tumour suppressor protein pVHL.
FEBS letters 2007;581(7):1397-402.
2007: Byrne Richard D; Rosivatz Erika; Parsons Maddy; Larijani Banafshé; Parker Peter J; Ng Tony; Woscholski Rudiger
Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha.
Cellular signalling 2007;19(2):321-9.
2006: Fili N; Calleja V; Woscholski R; Parker P J; Larijani B
Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(42):15473-8.
2006: Iturrioz Xavier; Durgan Joanne; Calleja Véronique; Larijani Banafshé; Okuda Heiwa; Whelan Richard; Parker Peter J
The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta.
The Biochemical journal 2006;397(1):109-20.
2006: Kong Anthony; Leboucher Pierre; Leek Russell; Calleja Véronique; Winter Stuart; Harris Adrian; Parker Peter J; Larijani Banafshé
Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer.
Cancer research 2006;66(5):2834-43.
2005: Kermorgant S; Parker P J
c-Met signalling: spatio-temporal decisions.
Cell cycle (Georgetown, Tex.) 2005;4(3):352-5.
2004: Kermorgant Stéphanie; Zicha Daniel; Parker Peter J
PKC controls HGF-dependent c-Met traffic, signalling and cell migration.
The EMBO journal 2004;23(19):3721-34.
2004: Jeffries Tim R; Dove Stephen K; Michell Robert H; Parker Peter J
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49.
Molecular biology of the cell 2004;15(6):2652-63.
2004: Dove Stephen K; Piper Robert C; McEwen Robert K; Yu Jong W; King Megan C; Hughes David C; Thuring Jan; Holmes Andrew B; Cooke Frank T; Michell Robert H; Parker Peter J; Lemmon Mark A
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.
The EMBO journal 2004;23(9):1922-33.
2004: Parkinson Scott J; Le Good J Anne; Whelan Richard D H; Whitehead Phil; Parker Peter J
Identification of PKCzetaII: an endogenous inhibitor of cell polarity.
The EMBO journal 2004;23(1):77-88.
2004: Parker Peter J; Murray-Rust Judith
PKC at a glance.
Journal of cell science 2004;117(Pt 2):131-2.
2003: Kermorgant Stephanie; Zicha Daniel; Parker Peter J
Protein kinase C controls microtubule-based traffic but not proteasomal degradation of c-Met.
The Journal of biological chemistry 2003;278(31):28921-9.
2003: Ivaska Johanna; Bosca Lisardo; Parker Peter J
PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.
Nature cell biology 2003;5(4):363-9.
2002: Srivastava Jyoti; Procyk Katarzyna J; Iturrioz Xavier; Parker Peter J
Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.
The Biochemical journal 2002;368(Pt 1):349-55.
2002: Ivaska Johanna; Whelan Richard D H; Watson Rose; Parker Peter J
PKC epsilon controls the traffic of beta1 integrins in motile cells.
The EMBO journal 2002;21(14):3608-19.
2002: Hughes William E; Larijani Banafshé; Parker Peter J
Detecting protein-phospholipid interactions. Epidermal growth factor-induced activation of phospholipase D1b in situ.
The Journal of biological chemistry 2002;277(25):22974-9.
2002: Srivastava Jyoti; Goris Jozef; Dilworth Stephen M; Parker Peter J
Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides.
FEBS letters 2002;516(1-3):265-9.
2001: Parker P J; Parkinson S J
AGC protein kinase phosphorylation and protein kinase C.
Biochemical Society transactions 2001;29(Pt 6):860-3.
2001: Hughes W E; Parker P J
Endosomal localization of phospholipase D 1a and 1b is defined by the C-termini of the proteins, and is independent of activity.
The Biochemical journal 2001;356(Pt 3):727-36.
2001: Vanhaesebroeck B; Leevers S J; Ahmadi K; Timms J; Katso R; Driscoll P C; Woscholski R; Parker P J; Waterfield M D
Synthesis and function of 3-phosphorylated inositol lipids.
Annual review of biochemistry 2001;70():535-602.
2000: Parekh D B; Katso R M; Leslie N R; Downes C P; Procyk K J; Waterfield M D; Parker P J
Beta1-integrin and PTEN control the phosphorylation of protein kinase C.
The Biochemical journal 2000;352 Pt 2():425-33.
2000: Hughes W E; Cooke F T; Parker P J
Sac phosphatase domain proteins.
The Biochemical journal 2000;350 Pt 2():337-52.
2000: Prevostel C; Alice V; Joubert D; Parker P J
Protein kinase C(alpha) actively downregulates through caveolae-dependent traffic to an endosomal compartment.
Journal of cell science 2000;113 ( Pt 14)():2575-84.
2000: Flynn P; Mellor H; Casamassima A; Parker P J
Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.
The Journal of biological chemistry 2000;275(15):11064-70.
2000: Parekh D B; Ziegler W; Parker P J
Multiple pathways control protein kinase C phosphorylation.
The EMBO journal 2000;19(4):496-503.
2000: Sayers L G; Katayama S; Nakano K; Mellor H; Mabuchi I; Toda T; Parker P J
Rho-dependence of Schizosaccharomyces pombe Pck2.
Genes to cells : devoted to molecular & cellular mechanisms 2000;5(1):17-27.
2000: Hughes W E; Woscholski R; Cooke F T; Patrick R S; Dove S K; McDonald N Q; Parker P J
SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases.
The Journal of biological chemistry 2000;275(2):801-8.
1999: Parekh D; Ziegler W; Yonezawa K; Hara K; Parker P J
Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilon.
The Journal of biological chemistry 1999;274(49):34758-64.
1999: McEwen R K; Dove S K; Cooke F T; Painter G F; Holmes A B; Shisheva A; Ohya Y; Parker P J; Michell R H
Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases.
The Journal of biological chemistry 1999;274(48):33905-12.
1999: Hansra G; Garcia-Paramio P; Prevostel C; Whelan R D; Bornancin F; Parker P J
Multisite dephosphorylation and desensitization of conventional protein kinase C isotypes.
The Biochemical journal 1999;342 ( Pt 2)():337-44.
1999: Dove S K; McEwen R K; Cooke F T; Parker P J; Michell R H
Phosphatidylinositol 3,5-bisphosphate: a novel lipid that links stress responses to membrane trafficking events.
Biochemical Society transactions 1999;27(4):674-7.
1999: Ng T; Shima D; Squire A; Bastiaens P I; Gschmeissner S; Humphries M J; Parker P J
PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic.
The EMBO journal 1999;18(14):3909-23.
1999: Ziegler W H; Parekh D B; Le Good J A; Whelan R D; Kelly J J; Frech M; Hemmings B A; Parker P J
Rapamycin-sensitive phosphorylation of PKC on a carboxy-terminal site by an atypical PKC complex.
Current biology : CB 1999;9(10):522-9.
1999: Whelan R D; Kiley S C; Parker P J
Tetradecanoyl phorbol acetate-induced microtubule reorganization is required for sustained mitogen-activated protein kinase activation and morphological differentiation of U937 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(4):271-7.
1999: Blake R A; Garcia-Paramio P; Parker P J; Courtneidge S A
Src promotes PKCdelta degradation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(4):231-41.
1999: Ng T; Squire A; Hansra G; Bornancin F; Prevostel C; Hanby A; Harris W; Barnes D; Schmidt S; Mellor H; Bastiaens P I; Parker P J
Imaging protein kinase Calpha activation in cells.
Science (New York, N.Y.) 1999;283(5410):2085-9.
1998: Cooke F T; Dove S K; McEwen R K; Painter G; Holmes A B; Hall M N; Michell R H; Parker P J
The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae.
Current biology : CB 1998;8(22):1219-22.
1998: Le Good J A; Ziegler W H; Parekh D B; Alessi D R; Cohen P; Parker P J
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
Science (New York, N.Y.) 1998;281(5385):2042-5.
1998: Garcia-Paramio P; Cabrerizo Y; Bornancin F; Parker P J
The broad specificity of dominant inhibitory protein kinase C mutants infers a common step in phosphorylation.
The Biochemical journal 1998;333 ( Pt 3)():631-6.
1998: Pappa H; Dekker L V; Parker P J; McDonald N Q
Preliminary X-ray analysis of a C2-like domain from protein kinase C-delta.
Acta crystallographica. Section D, Biological crystallography 1998;54(Pt 4):693-6.
1998: Woscholski R; Finan P M; Radley E; Parker P J
Identification and characterisation of a novel splice variant of synaptojanin1.
FEBS letters 1998;432(1-2):5-8.
1998: Pappa H; Murray-Rust J; Dekker L V; Parker P J; McDonald N Q
Crystal structure of the C2 domain from protein kinase C-delta.
Structure (London, England : 1993) 1998;6(7):885-94.
1998: Mellor H; Parker P J
The extended protein kinase C superfamily.
The Biochemical journal 1998;332 ( Pt 2)():281-92.
1998: Whelan R D; Parker P J
Loss of protein kinase C function induces an apoptotic response.
Oncogene 1998;16(15):1939-44.
1998: Mellor H; Flynn P; Nobes C D; Hall A; Parker P J
PRK1 is targeted to endosomes by the small GTPase, RhoB.
The Journal of biological chemistry 1998;273(9):4811-4.
1998: Flynn P; Mellor H; Palmer R; Panayotou G; Parker P J
Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif.
The Journal of biological chemistry 1998;273(5):2698-705.
1997: Woscholski R; Parker P J
Inositol lipid 5-phosphatases--traffic signals and signal traffic.
Trends in biochemical sciences 1997;22(11):427-31.
1997: Dove S K; Cooke F T; Douglas M R; Sayers L G; Parker P J; Michell R H
Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis.
Nature 1997;390(6656):187-92.
1997: Dekker L V; Parker P J
Regulated binding of the protein kinase C substrate GAP-43 to the V0/C2 region of protein kinase C-delta.
The Journal of biological chemistry 1997;272(19):12747-53.
1997: Woscholski R; Finan P M; Radley E; Totty N F; Sterling A E; Hsuan J J; Waterfield M D; Parker P J
Synaptojanin is the major constitutively active phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase in rodent brain.
The Journal of biological chemistry 1997;272(15):9625-8.
1997: Kiley S C; Parker P J
Defective microtubule reorganization in phorbol ester-resistant U937 variants: reconstitution of the normal cell phenotype with nocodazole treatment.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(2):231-42.
1997: Kiley S C; Adams P D; Parker P J
Cloning and characterization of phorbol ester differentiation-resistant U937 cell variants.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(2):221-30.
1997: Bornancin F; Parker P J
Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state.
The Journal of biological chemistry 1997;272(6):3544-9.
1996: Hansra G; Bornancin F; Whelan R; Hemmings B A; Parker P J
12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Calpha correlates with the presence of a membrane-associated protein phosphatase 2A heterotrimer.
The Journal of biological chemistry 1996;271(51):32785-8.
1996: Srinivasan N; Bax B; Blundell T L; Parker P J
Structural aspects of the functional modules in human protein kinase-C alpha deduced from comparative analyses.
Proteins 1996;26(2):217-35.
1996: Schönwasser D C; Palmer R H; Herget T; Parker P J
p42 MAPK phosphorylates 80 kDa MARCKS at Ser-113.
FEBS letters 1996;395(1):1-5.
1996: Olivier A R; Hansra G; Pettitt T R; Wakelam M J; Parker P J
The co-mitogenic combination of transforming growth factor beta 1 and bombesin protects protein kinase C-delta from late-phase down-regulation, despite synergy in diacylglycerol accumulation.
The Biochemical journal 1996;318 ( Pt 2)():519-25.
1996: Oehrlein S A; Parker P J; Herget T
Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation.
The Biochemical journal 1996;317 ( Pt 1)():219-24.
1996: Palmer R H; Schönwasser D C; Rahman D; Pappin D J; Herget T; Parker P J
PRK1 phosphorylates MARCKS at the PKC sites: serine 152, serine 156 and serine 163.
FEBS letters 1996;378(3):281-5.
1995: Woscholski R; Waterfield M D; Parker P J
Purification and biochemical characterization of a mammalian phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
The Journal of biological chemistry 1995;270(52):31001-7.
1995: Herget T; Oehrlein S A; Pappin D J; Rozengurt E; Parker P J
The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C.
European journal of biochemistry / FEBS 1995;233(2):448-57.
1995: de Vente J E; Kukoly C A; Bryant W O; Posekany K J; Chen J; Fletcher D J; Parker P J; Pettit G J; Lozano G; Cook P P
Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death.
The Journal of clinical investigation 1995;96(4):1874-86.
1995: Palmer R H; Dekker L V; Woscholski R; Le Good J A; Gigg R; Parker P J
Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes.
The Journal of biological chemistry 1995;270(38):22412-6.
1995: Clerk A; Bogoyevitch M A; Fuller S J; Lazou A; Parker P J; Sugden P H
Expression of protein kinase C isoforms during cardiac ventricular development.
The American journal of physiology 1995;269(3 Pt 2):H1087-97.
1995: Woscholski R; Kodaki T; Palmer R H; Waterfield M D; Parker P J
Modulation of the substrate specificity of the mammalian phosphatidylinositol 3-kinase by cholesterol sulfate and sulfatide.
Biochemistry 1995;34(36):11489-93.
1995: Kiley S C; Jaken S; Whelan R; Parker P J
Intracellular targeting of protein kinase C isoenzymes: functional implications.
Biochemical Society transactions 1995;23(3):601-5.
1995: Dimitrijevic S M; Ryves W J; Parker P J; Evans F J
Characterization of phorbol ester binding to protein kinase C isotypes.
Molecular pharmacology 1995;48(2):259-67.
1995: Dekker L V; Palmer R H; Parker P J
The protein kinase C and protein kinase C related gene families.
Current opinion in structural biology 1995;5(3):396-402.
1995: Kodaki T; Woscholski R; Parker P J
V-Ras activates phosphatidylinositol 3-kinase.
Biochemical Society transactions 1995;23(2):195S.
1995: Sharma P; Ryves W J; Gordge P C; Evans A T; Shaun N; Thomas B; Parker P J; Evans F J
Properties of a resiniferatoxin-stimulated, calcium inhibited but phosphatidylserine-dependent kinase, which is distinct from protein kinase C isotypes alpha, beta 1, gamma, delta, epsilon and eta.
The Journal of pharmacy and pharmacology 1995;47(4):297-306.
1995: Ways D K; Kukoly C A; deVente J; Hooker J L; Bryant W O; Posekany K J; Fletcher D J; Cook P P; Parker P J
MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype.
The Journal of clinical investigation 1995;95(4):1906-15.
1995: Kiley S C; Parker P J
Differential localization of protein kinase C isozymes in U937 cells: evidence for distinct isozyme functions during monocyte differentiation.
Journal of cell science 1995;108 ( Pt 3)():1003-16.
1995: Goode N T; Hajibagheri M A; Parker P J
Protein kinase C (PKC)-induced PKC down-regulation. Association with up-regulation of vesicle traffic.
The Journal of biological chemistry 1995;270(6):2669-73.
1995: Parker P J; Bosca L; Dekker L; Goode N T; Hajibagheri N; Hansra G
Protein kinase C (PKC)-induced PKC degradation: a model for down-regulation.
Biochemical Society transactions 1995;23(1):153-5.
1995: Woscholski R; Kodaki T; Parker P J
The lipid kinase activity of the phosphatidylinositol 3-kinase is affected by its intrinsic protein kinase activity.
Biochemical Society transactions 1995;23(1):14S.
1995: Palmer R H; Ridden J; Parker P J
Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family.
European journal of biochemistry / FEBS 1995;227(1-2):344-51.
1994: Palmer R H; Ridden J; Parker P J
Identification of multiple, novel, protein kinase C-related gene products.
FEBS letters 1994;356(1):5-8.
1994: Decock J B; Gillespie-Brown J; Parker P J; Sugden P H; Fuller S J
Classical, novel and atypical isoforms of PKC stimulate ANF- and TRE/AP-1-regulated-promoter activity in ventricular cardiomyocytes.
FEBS letters 1994;356(2-3):275-8.
1994: Woscholski R; Dhand R; Fry M J; Waterfield M D; Parker P J
Biochemical characterization of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha.p85 alpha forms of the mammalian phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1994;269(40):25067-72.
1994: Kodaki T; Woscholski R; Hallberg B; Rodriguez-Viciana P; Downward J; Parker P J
The activation of phosphatidylinositol 3-kinase by Ras.
Current biology : CB 1994;4(9):798-806.
1994: Goode N T; Hajibagheri M A; Warren G; Parker P J
Expression of mammalian protein kinase C in Schizosaccharomyces pombe: isotype-specific induction of growth arrest, vesicle formation, and endocytosis.
Molecular biology of the cell 1994;5(8):907-20.
1994: Cazaubon S; Bornancin F; Parker P J
Threonine-497 is a critical site for permissive activation of protein kinase C alpha.
The Biochemical journal 1994;301 ( Pt 2)():443-8.
1994: Junco M; Webster C; Crawford C; Bosca L; Parker P J
Protein kinase C V3 domain mutants with differential sensitivities to m-calpain are not resistant to phorbol-ester-induced down-regulation.
European journal of biochemistry / FEBS 1994;223(1):259-63.
1994: McKinnon M; Parker P J
Phospholipase-D activation can be negatively regulated through the action of protein kinase C.
Biochimica et biophysica acta 1994;1222(1):109-12.
1994: Woscholski R; Kodaki T; McKinnon M; Waterfield M D; Parker P J
A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3-kinase.
FEBS letters 1994;342(2):109-14.
1994: Kiley S C; Olivier A R; Gordge P C; Ryves W J; Evans F J; Ways D K; Parker P J
12-Deoxyphorbol-13-O-phenylacetate-20-acetate is not protein kinase C-beta isozyme-selective in vivo.
Carcinogenesis 1994;15(2):319-24.
1994: Ways D K; Qin W; Garris T O; Chen J; Hao E; Cooper D R; Usala S J; Parker P J; Cook P P
Effects of chronic phorbol ester treatment on protein kinase C activity, content, and gene expression in the human monoblastoid U937 cell.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(2):161-9.
1994: Dekker L V; Parker P J
Protein kinase C--a question of specificity.
Trends in biochemical sciences 1994;19(2):73-7.
1994: Goode N T; Parker P J
A phorbol ester-responsive PKC-zeta generated by fusion with the regulatory domain of PKC-delta.
FEBS letters 1994;340(1-2):145-50.
1994: Kodaki T; Woscholski R; Emr S; Waterfield M D; Nurse P; Parker P J
Mammalian phosphatidylinositol 3'-kinase induces a lethal phenotype on expression in Schizosaccharomyces pombe; comparison with the VPS34 gene product.
European journal of biochemistry / FEBS 1994;219(3):775-80.
1994: Olivier A R; Parker P J
Bombesin, platelet-derived growth factor, and diacylglycerol induce selective membrane association and down-regulation of protein kinase C isotypes in Swiss 3T3 cells.
The Journal of biological chemistry 1994;269(4):2758-63.
1994: Bogoyevitch M A; Glennon P E; Andersson M B; Clerk A; Lazou A; Marshall C J; Parker P J; Sugden P H
Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.
The Journal of biological chemistry 1994;269(2):1110-9.
1993: Parker P J
Antibodies to fluorylsulfonylbenzoyladenosine permit identification of protein kinases.
FEBS letters 1993;334(3):347-50.
1993: Schnabel P; Camps M; Carozzi A; Parker P J; Gierschik P
Mutational analysis of phospholipase C-beta 2. Identification of regions required for membrane association and stimulation by guanine-nucleotide-binding protein beta gamma subunits.
European journal of biochemistry / FEBS 1993;217(3):1109-15.
1993: Clerk A; Bogoyevitch M A; Parker P J; Sugden P H
Down-regulation of protein kinase C isotypes during postnatal development of rat heart.
Biochemical Society transactions 1993;21(4):385S.
1993: Dekker L V; McIntyre P; Parker P J
Mutagenesis of the regulatory domain of rat protein kinase C-eta. A molecular basis for restricted histone kinase activity.
The Journal of biological chemistry 1993;268(26):19498-504.
1993: Ways D K; Qin W; Cook P; Parker P J; Menke J B; Hao E; Smith A M; Jones C; Hershman J M; Geffner M E
Dominant and nondominant negative C-erbA beta 1 receptors associated with thyroid hormone resistance syndromes augment 12-O-tetradecanoyl-phorbol-13-acetate induction of the collagenase promoter and exhibit defective 3,5,3'-triiodothyronine-mediated repression.
Molecular endocrinology (Baltimore, Md.) 1993;7(9):1112-20.
1993: Dekker L V; McIntyre P; Parker P J
Altered substrate selectivity of PKC-eta pseudosubstrate site mutants.
FEBS letters 1993;329(1-2):129-33.
1993: Bogoyevitch M A; Parker P J; Sugden P H
Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin.
Circulation research 1993;72(4):757-67.
1993: Ruiz-Larrea F; Vicendo P; Yaish P; End P; Panayotou G; Fry M J; Morgan S J; Thompson A; Parker P J; Waterfield M D
Characterization of the bovine brain cytosolic phosphatidylinositol 3-kinase complex.
The Biochemical journal 1993;290 ( Pt 2)():609-16.
1993: Carozzi A; Camps M; Gierschik P; Parker P J
Activation of phosphatidylinositol lipid-specific phospholipase C-beta 3 by G-protein beta gamma subunits.
FEBS letters 1993;315(3):340-2.
1992: Camps M; Carozzi A; Schnabel P; Scheer A; Parker P J; Gierschik P
Isozyme-selective stimulation of phospholipase C-beta 2 by G protein beta gamma-subunits.
Nature 1992;360(6405):684-6.
1992: Carozzi A J; Kriz R W; Webster C; Parker P J
Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.
European journal of biochemistry / FEBS 1992;210(2):521-9.
1992: Dekker L V; Parker P J; McIntyre P
Biochemical properties of rat protein kinase C-eta expressed in COS cells.
FEBS letters 1992;312(2-3):195-9.
1992: Kiley S C; Parker P J; Fabbro D; Jaken S
Selective redistribution of protein kinase C isozymes by thapsigargin and staurosporine.
Carcinogenesis 1992;13(11):1997-2001.
1992: Ways D K; Messer B R; Garris T O; Qin W; Cook P P; Parker P J
Modulation of protein kinase C-epsilon by phorbol esters in the monoblastoid U937 cell.
Cancer research 1992;52(20):5604-9.
1992: Parker P J; Waterfield M D
Phosphatidylinositol 3-kinase: a novel effector.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1992;3(10):747-52.
1992: Olivier A R; Kiley S C; Pears C; Schaap D; Jaken S; Parker P J
Protein kinase C-delta and -epsilon: a functional appraisal.
Biochemical Society transactions 1992;20(3):603-7.
1992: Goode N; Hughes K; Woodgett J R; Parker P J
Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.
The Journal of biological chemistry 1992;267(24):16878-82.
1992: Parker P J; Cook P P; Olivier A R; Pears C; Ways D K; Webster C
Protein kinase C.
Biochemical Society transactions 1992;20(2):415-8.
1992: Pears C; Stabel S; Cazaubon S; Parker P J
Studies on the phosphorylation of protein kinase C-alpha.
The Biochemical journal 1992;283 ( Pt 2)():515-8.
1992: Ways D K; Cook P P; Webster C; Parker P J
Effect of phorbol esters on protein kinase C-zeta.
The Journal of biological chemistry 1992;267(7):4799-805.
1992: Kiley S C; Parker P J; Fabbro D; Jaken S
Hormone- and phorbol ester-activated protein kinase C isozymes mediate a reorganization of the actin cytoskeleton associated with prolactin secretion in GH4C1 cells.
Molecular endocrinology (Baltimore, Md.) 1992;6(1):120-31.
1991: Kiley S C; Parker P J; Fabbro D; Jaken S
Differential regulation of protein kinase C isozymes by thyrotropin-releasing hormone in GH4C1 cells.
The Journal of biological chemistry 1991;266(35):23761-8.
1991: Olivier A R; Parker P J
Expression and characterization of protein kinase C-delta.
European journal of biochemistry / FEBS 1991;200(3):805-10.
1991: Adams P D; Parker P J
TPA-induced activation of MAP kinase.
FEBS letters 1991;290(1-2):77-82.
1991: Ryves W J; Evans A T; Olivier A R; Parker P J; Evans F J
Activation of the PKC-isotypes alpha, beta 1, gamma, delta and epsilon by phorbol esters of different biological activities.
FEBS letters 1991;288(1-2):5-9.
1991: Pears C; Parker P J
Down-regulation of a kinase defective PKC-alpha.
FEBS letters 1991;284(1):120-2.
1991: Pears C; Schaap D; Parker P J
The regulatory domain of protein kinase C-epsilon restricts the catalytic-domain-specificity.
The Biochemical journal 1991;276 ( Pt 1)():257-60.
1991: Evans F J; Parker P J; Olivier A R; Thomas S; Ryves W J; Evans A T; Gordge P; Sharma P
Phorbol ester activation of the isotypes of protein kinase C from bovine and rat brain.
Biochemical Society transactions 1991;19(2):397-402.
1991: Meldrum E; Parker P J; Carozzi A
The PtdIns-PLC superfamily and signal transduction.
Biochimica et biophysica acta 1991;1092(1):49-71.
1991: Meldrum E; Kriz R W; Totty N; Parker P J
A second gene product of the inositol-phospholipid-specific phospholipase C delta subclass.
European journal of biochemistry / FEBS 1991;196(1):159-65.
1991: Stabel S; Schaap D; Parker P J
Expression of protein kinase C isotypes using baculovirus vectors.
Methods in enzymology 1991;200():670-3.
1990: Marais R M; Nguyen O; Woodgett J R; Parker P J
Studies on the primary sequence requirements for PKC-alpha, -beta 1 and -gamma peptide substrates.
FEBS letters 1990;277(1-2):151-5.
1990: Pears C J; Kour G; House C; Kemp B E; Parker P J
Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation.
European journal of biochemistry / FEBS 1990;194(1):89-94.
1990: Schaap D; Hsuan J; Totty N; Parker P J
Proteolytic activation of protein kinase C-epsilon.
European journal of biochemistry / FEBS 1990;191(2):431-5.
1990: Schaap D; Parker P J
Expression, purification, and characterization of protein kinase C-epsilon.
The Journal of biological chemistry 1990;265(13):7301-7.
1989: Marais R M; Parker P J
Purification and characterisation of bovine brain protein kinase C isotypes alpha, beta and gamma.
European journal of biochemistry / FEBS 1989;182(1):129-37.
1989: Parker P J; Bajaj M; Marais R; Mitchell F; Pears C; Stabel S
Protein kinase C as a second messenger target.
Biochemical Society transactions 1989;17(2):279-80.
1989: Schaap D; Parker P J; Bristol A; Kriz R; Knopf J
Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity.
FEBS letters 1989;243(2):351-7.
1988: Katan M; Kriz R W; Totty N; Philp R; Meldrum E; Aldape R A; Knopf J L; Parker P J
Determination of the primary structure of PLC-154 demonstrates diversity of phosphoinositide-specific phospholipase C activities.
Cell 1988;54(2):171-7.
1988: Parker P J; Marais R; Bajaj M; Mitchell F; King P; Young S; Ullrich A; Stabel S
Protein kinase C--structural studies.
Advances in experimental medicine and biology 1988;231():417-26.
1988: Katan M; Kriz R W; Totty N; Philp R; Meldrum E; Aldape R A; Knopf J; Parker P J
Primary structure of PLC-154.
Cold Spring Harbor symposia on quantitative biology 1988;53 Pt 2():921-6.
1987: Young S; Parker P J; Ullrich A; Stabel S
Down-regulation of protein kinase C is due to an increased rate of degradation.
The Biochemical journal 1987;244(3):775-9.

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