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Roy Parker

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Living Beings

Saccharomyces cerevisiae

Chemicals & Drugs

Concepts & Ideas

Physiology

Genes & Molecular Sequences

Fungal Genes

Anatomy

Cytoplasmic Structures

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Network (preview)

Co-Publications
Name
13
Muhlrad, Denise
8
van Hoof, Ambro
6
Valencia-Sanchez, Marco Antonio
5
Tucker, Morgan
5
Sheth, Ujwal
5
Teixeira, Daniela
5
Coller, Jeff
4
Decker, Carolyn
4
Doma, Meenakshi
4
Hilleren, P
3
Hannon, Gregory
3
He, Wei
3
Brengues, Muriel
3
Tharun, S
3
Staples, Robin

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Publications

TOP 3
Luhtala Natalie; Parker Roy
LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels.
Thompson Debrah M; Parker Roy
Stressing out over tRNA cleavage.
Passos Dario O; Doma Meenakshi K; Shoemaker Christopher J; Muhlrad Denise; Green Rachel; Weissman Jonathan; Hollien Julie; Parker Roy
Analysis of Dom34 and its function in no-go decay.

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All Publications

2009: Luhtala Natalie; Parker Roy
LSM1 over-expression in Saccharomyces cerevisiae depletes U6 snRNA levels.
Nucleic acids research 2009;37(16):5529-36.
2009: Thompson Debrah M; Parker Roy
Stressing out over tRNA cleavage.
Cell 2009;138(2):215-9.
2009: Passos Dario O; Doma Meenakshi K; Shoemaker Christopher J; Muhlrad Denise; Green Rachel; Weissman Jonathan; Hollien Julie; Parker Roy
Analysis of Dom34 and its function in no-go decay.
Molecular biology of the cell 2009;20(13):3025-32.
2009: Balagopal Vidya; Parker Roy
Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs.
Current opinion in cell biology 2009;21(3):403-8.
2009: Swisher Kylie D; Parker Roy
Related mechanisms for mRNA and rRNA quality control.
Molecular cell 2009;34(4):401-2.
2009: Chekulaeva Marina; Filipowicz Witold; Parker Roy
Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila.
RNA (New York, N.Y.) 2009;15(5):794-803.
2009: Thompson Debrah M; Parker Roy
The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae.
The Journal of cell biology 2009;185(1):43-50.
2009: Rajyaguru Purusharth; Parker Roy
CGH-1 and the control of maternal mRNAs.
Trends in cell biology 2009;19(1):24-8.
2009: Balagopal Vidya; Parker Roy
Stm1 modulates mRNA decay and Dhh1 function in Saccharomyces cerevisiae.
Genetics 2009;181(1):93-103.
2008: Buchan J Ross; Muhlrad Denise; Parker Roy
P bodies promote stress granule assembly in Saccharomyces cerevisiae.
The Journal of cell biology 2008;183(3):441-55.
2008: Hilliker Angela; Parker Roy
Stressed out? Make some modifications!
Nature cell biology 2008;10(10):1129-30.
2008: Thompson Debrah M; Lu Cheng; Green Pamela J; Parker Roy
tRNA cleavage is a conserved response to oxidative stress in eukaryotes.
RNA (New York, N.Y.) 2008;14(10):2095-103.
2008: Beckham Carla J; Parker Roy
P bodies, stress granules, and viral life cycles.
Cell host & microbe 2008;3(4):206-12.
2008: Beckham Carla; Hilliker Angela; Cziko Anne-Marie; Noueiry Amine; Ramaswami Mani; Parker Roy
The DEAD-box RNA helicase Ded1p affects and accumulates in Saccharomyces cerevisiae P-bodies.
Molecular biology of the cell 2008;19(3):984-93.
2008: Pilkington Guy R; Parker Roy
Pat1 contains distinct functional domains that promote P-body assembly and activation of decapping.
Molecular and cellular biology 2008;28(4):1298-312.
2008: Nissan Tracy; Parker Roy
Analyzing P-bodies in Saccharomyces cerevisiae.
Methods in enzymology 2008;448():507-20.
2008: Passos Dario O; Parker Roy
Analysis of cytoplasmic mRNA decay in Saccharomyces cerevisiae.
Methods in enzymology 2008;448():409-27.
2007: Buchan J Ross; Parker Roy
Molecular biology. The two faces of miRNA.
Science (New York, N.Y.) 2007;318(5858):1877-8.
2007: Doma Meenakshi K; Parker Roy
RNA quality control in eukaryotes.
Cell 2007;131(4):660-8.
2007: Decker Carolyn J; Teixeira Daniela; Parker Roy
Edc3p and a glutamine/asparagine-rich domain of Lsm4p function in processing body assembly in Saccharomyces cerevisiae.
The Journal of cell biology 2007;179(3):437-49.
2007: Beckham Carla J; Light Heather R; Nissan T Amar; Ahlquist Paul; Parker Roy; Noueiry Amine
Interactions between brome mosaic virus RNAs and cytoplasmic processing bodies.
Journal of virology 2007;81(18):9759-68.
2007: Brengues Muriel; Parker Roy
Accumulation of polyadenylated mRNA, Pab1p, eIF4E, and eIF4G with P-bodies in Saccharomyces cerevisiae.
Molecular biology of the cell 2007;18(7):2592-602.
2007: Teixeira Daniela; Parker Roy
Analysis of P-body assembly in Saccharomyces cerevisiae.
Molecular biology of the cell 2007;18(6):2274-87.
2007: Parker Roy; Sheth Ujwal
P bodies and the control of mRNA translation and degradation.
Molecular cell 2007;25(5):635-46.
2007: Thompson Debrah M; Parker Roy
Cytoplasmic decay of intergenic transcripts in Saccharomyces cerevisiae.
Molecular and cellular biology 2007;27(1):92-101.
2006: Barbee Scott A; Estes Patricia S; Cziko Anne-Marie; Hillebrand Jens; Luedeman Rene A; Coller Jeff M; Johnson Nick; Howlett Iris C; Geng Cuiyun; Ueda Ryu; Brand Andrea H; Newbury Sarah F; Wilhelm James E; Levine Richard B; Nakamura Akira; Parker Roy; Ramaswami Mani
Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies.
Neuron 2006;52(6):997-1009.
2006: Doma Meenakshi K; Parker Roy
Revenge of the NRD: preferential degradation of nonfunctional eukaryotic rRNA.
Developmental cell 2006;11(6):757-8.
2006: Hilgers Valérie; Teixeira Daniela; Parker Roy
Translation-independent inhibition of mRNA deadenylation during stress in Saccharomyces cerevisiae.
RNA (New York, N.Y.) 2006;12(10):1835-45.
2006: Segal Scott P; Dunckley Travis; Parker Roy
Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae.
Molecular and cellular biology 2006;26(13):5120-30.
2006: Sheth Ujwal; Parker Roy
Targeting of aberrant mRNAs to cytoplasmic processing bodies.
Cell 2006;125(6):1095-109.
2006: Decker Carolyn J; Parker Roy
CAR-1 and trailer hitch: driving mRNP granule function at the ER?
The Journal of cell biology 2006;173(2):159-63.
2006: Doma Meenakshi K; Parker Roy
Endonucleolytic cleavage of eukaryotic mRNAs with stalls in translation elongation.
Nature 2006;440(7083):561-4.
2006: Valencia-Sanchez Marco Antonio; Liu Jidong; Hannon Gregory J; Parker Roy
Control of translation and mRNA degradation by miRNAs and siRNAs.
Genes & development 2006;20(5):515-24.
2005: Liu Jidong; Rivas Fabiola V; Wohlschlegel James; Yates John R; Parker Roy; Hannon Gregory J
A role for the P-body component GW182 in microRNA function.
Nature cell biology 2005;7(12):1261-6.
2005: Brengues Muriel; Teixeira Daniela; Parker Roy
Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies.
Science (New York, N.Y.) 2005;310(5747):486-9.
2005: Coller Jeff; Parker Roy
General translational repression by activators of mRNA decapping.
Cell 2005;122(6):875-86.
2005: Wilson Marenda A; Meaux Stacie; Parker Roy; van Hoof Ambro
Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(29):10244-9.
2005: Liu Jidong; Valencia-Sanchez Marco Antonio; Hannon Gregory J; Parker Roy
MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.
Nature cell biology 2005;7(7):719-23.
2005: Teixeira Daniela; Sheth Ujwal; Valencia-Sanchez Marco A; Brengues Muriel; Parker Roy
Processing bodies require RNA for assembly and contain nontranslating mRNAs.
RNA (New York, N.Y.) 2005;11(4):371-82.
2005: Muhlrad Denise; Parker Roy
The yeast EDC1 mRNA undergoes deadenylation-independent decapping stimulated by Not2p, Not4p, and Not5p.
The EMBO journal 2005;24(5):1033-45.
2004: Baker Kristian E; Coller Jeff; Parker Roy
The yeast Apq12 protein affects nucleocytoplasmic mRNA transport.
RNA (New York, N.Y.) 2004;10(9):1352-8.
2004: Baker Kristian E; Parker Roy
Nonsense-mediated mRNA decay: terminating erroneous gene expression.
Current opinion in cell biology 2004;16(3):293-9.
2004: Kshirsagar Meenakshi; Parker Roy
Identification of Edc3p as an enhancer of mRNA decapping in Saccharomyces cerevisiae.
Genetics 2004;166(2):729-39.
2004: Parker Roy; Song Haiwei
The enzymes and control of eukaryotic mRNA turnover.
Nature structural & molecular biology 2004;11(2):121-7.
2004: Coller Jeff; Parker Roy
Eukaryotic mRNA decapping.
Annual review of biochemistry 2004;73():861-90.
2003: Cao Dan; Parker Roy
Computational modeling and experimental analysis of nonsense-mediated decay in yeast.
Cell 2003;113(4):533-45.
2003: Sheth Ujwal; Parker Roy
Decapping and decay of messenger RNA occur in cytoplasmic processing bodies.
Science (New York, N.Y.) 2003;300(5620):805-8.
2003: Schwartz David; Decker Carolyn J; Parker Roy
The enhancer of decapping proteins, Edc1p and Edc2p, bind RNA and stimulate the activity of the decapping enzyme.
RNA (New York, N.Y.) 2003;9(2):239-51.
2003: Steiger Michelle; Carr-Schmid Anne; Schwartz David C; Kiledjian Megerditch; Parker Roy
Analysis of recombinant yeast decapping enzyme.
RNA (New York, N.Y.) 2003;9(2):231-8.
2002: Decker Carolyn J; Parker Roy
mRNA decay enzymes: decappers conserved between yeast and mammals.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(20):12512-4.
2002: van Hoof Ambro; Parker Roy
Messenger RNA degradation: beginning at the end.
Current biology : CB 2002;12(8):R285-7.
2002: van Hoof Ambro; Frischmeyer Pamela A; Dietz Harry C; Parker Roy
Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.
Science (New York, N.Y.) 2002;295(5563):2262-4.
2002: Frischmeyer Pamela A; van Hoof Ambro; O'Donnell Kathryn; Guerrerio Anthony L; Parker Roy; Dietz Harry C
An mRNA surveillance mechanism that eliminates transcripts lacking termination codons.
Science (New York, N.Y.) 2002;295(5563):2258-61.
2002: Tucker Morgan; Staples Robin R; Valencia-Sanchez Marco A; Muhlrad Denise; Parker Roy
Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae.
The EMBO journal 2002;21(6):1427-36.
2002: Steiger Michelle A; Parker Roy
Analyzing mRNA decay in Saccharomyces cerevisiae.
Methods in enzymology 2002;351():648-60.
2001: Coller J M; Tucker M; Sheth U; Valencia-Sanchez M A; Parker R
The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes.
RNA (New York, N.Y.) 2001;7(12):1717-27.
2001: Tharun S; Parker R
Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs.
Molecular cell 2001;8(5):1075-83.
2001: Hilleren P; McCarthy T; Rosbash M; Parker R; Jensen T H
Quality control of mRNA 3'-end processing is linked to the nuclear exosome.
Nature 2001;413(6855):538-42.
2001: Cao D; Parker R
Computational modeling of eukaryotic mRNA turnover.
RNA (New York, N.Y.) 2001;7(9):1192-212.
2001: He W; Parker R
The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation.
Genetics 2001;158(4):1445-55.
2001: Hilleren P; Parker R
Defects in the mRNA export factors Rat7p, Gle1p, Mex67p, and Rat8p cause hyperadenylation during 3'-end formation of nascent transcripts.
RNA (New York, N.Y.) 2001;7(5):753-64.
2001: Tucker M; Valencia-Sanchez M A; Staples R R; Chen J; Denis C L; Parker R
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae.
Cell 2001;104(3):377-86.
2001: Dunckley T; Tucker M; Parker R
Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae.
Genetics 2001;157(1):27-37.
2000: Olivas W; Parker R
The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast.
The EMBO journal 2000;19(23):6602-11.
2000: van Hoof A; Staples R R; Baker R E; Parker R
Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA.
Molecular and cellular biology 2000;20(21):8230-43.
2000: Schwartz D C; Parker R
mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E.
Molecular and cellular biology 2000;20(21):7933-42.
2000: He W; Parker R
Functions of Lsm proteins in mRNA degradation and splicing.
Current opinion in cell biology 2000;12(3):346-50.
2000: Jacobs Anderson J S; Parker R
Computational identification of cis-acting elements affecting post-transcriptional control of gene expression in Saccharomyces cerevisiae.
Nucleic acids research 2000;28(7):1604-17.
2000: Tharun S; He W; Mayes A E; Lennertz P; Beggs J D; Parker R
Yeast Sm-like proteins function in mRNA decapping and decay.
Nature 2000;404(6777):515-8.
2000: van Hoof A; Lennertz P; Parker R
Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast.
The EMBO journal 2000;19(6):1357-65.
2000: van Hoof A; Lennertz P; Parker R
Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs.
Molecular and cellular biology 2000;20(2):441-52.
2000: Tucker M; Parker R
Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae.
Annual review of biochemistry 2000;69():571-95.
1999: van Hoof A; Parker R
The exosome: a proteasome for RNA?
Cell 1999;99(4):347-50.
1999: Muhlrad D; Parker R
Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.
Molecular biology of the cell 1999;10(11):3971-8.
1999: Muhlrad D; Parker R
Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance.
RNA (New York, N.Y.) 1999;5(10):1299-307.
1999: Dunckley T; Parker R
The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif.
The EMBO journal 1999;18(19):5411-22.
1999: Schwartz D C; Parker R
Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae.
Molecular and cellular biology 1999;19(8):5247-56.
1999: Hilleren P; Parker R
mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?
RNA (New York, N.Y.) 1999;5(6):711-9.
1999: Tharun S; Parker R
Analysis of mutations in the yeast mRNA decapping enzyme.
Genetics 1999;151(4):1273-85.
1999: LaGrandeur T; Parker R
The cis acting sequences responsible for the differential decay of the unstable MFA2 and stable PGK1 transcripts in yeast include the context of the translational start codon.
RNA (New York, N.Y.) 1999;5(3):420-33.
1999: Hilleren P; Parker R
Mechanisms of mRNA surveillance in eukaryotes.
Annual review of genetics 1999;33():229-60.
1998: LaGrandeur T E; Parker R
Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme.
The EMBO journal 1998;17(5):1487-96.
1997: Olivas W M; Muhlrad D; Parker R
Analysis of the yeast genome: identification of new non-coding and small ORF-containing RNAs.
Nucleic acids research 1997;25(22):4619-25.
1996: Caponigro G; Parker R
mRNA turnover in yeast promoted by the MATalpha1 instability element.
Nucleic acids research 1996;24(21):4304-12.
1996: Hatfield L; Beelman C A; Stevens A; Parker R
Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae.
Molecular and cellular biology 1996;16(10):5830-8.
1996: Beelman C A; Stevens A; Caponigro G; LaGrandeur T E; Hatfield L; Fortner D M; Parker R
An essential component of the decapping enzyme required for normal rates of mRNA turnover.
Nature 1996;382(6592):642-6.
1996: Anderson J S; Parker R
RNA turnover: the helicase story unwinds.
Current biology : CB 1996;6(7):780-2.
1996: Caponigro G; Parker R
Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae.
Microbiological reviews 1996;60(1):233-49.
1996: LaGrandeur T E; Parker R
mRNA decapping activities and their biological roles.
Biochimie 1996;78(11-12):1049-55.
1995: Mandart E; Parker R
Effects of mutations in the Saccharomyces cerevisiae RNA14, RNA15, and PAP1 genes on polyadenylation in vivo.
Molecular and cellular biology 1995;15(12):6979-86.
1995: Caponigro G; Parker R
Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.
Genes & development 1995;9(19):2421-32.
1995: Muhlrad D; Decker C J; Parker R
Turnover mechanisms of the stable yeast PGK1 mRNA.
Molecular and cellular biology 1995;15(4):2145-56.
1995: Beelman C A; Parker R
Degradation of mRNA in eukaryotes.
Cell 1995;81(2):179-83.
1994: Muhlrad D; Parker R
Premature translational termination triggers mRNA decapping.
Nature 1994;370(6490):578-81.
1994: Decker C J; Parker R
Mechanisms of mRNA degradation in eukaryotes.
Trends in biochemical sciences 1994;19(8):336-40.
1994: Beelman C A; Parker R
Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA.
The Journal of biological chemistry 1994;269(13):9687-92.
1994: Muhlrad D; Decker C J; Parker R
Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.
Genes & development 1994;8(7):855-66.
1993: Caponigro G; Muhlrad D; Parker R
A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons.
Molecular and cellular biology 1993;13(9):5141-8.
1993: Decker C J; Parker R
A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.
Genes & development 1993;7(8):1632-43.
1993: Parker R; Siliciano P G
Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron.
Nature 1993;361(6413):660-2.
1992: Muhlrad D; Parker R
Mutations affecting stability and deadenylation of the yeast MFA2 transcript.
Genes & development 1992;6(11):2100-11.
1992: Heaton B; Decker C; Muhlrad D; Donahue J; Jacobson A; Parker R
Analysis of chimeric mRNAs derived from the STE3 mRNA identifies multiple regions within yeast mRNAs that modulate mRNA decay.
Nucleic acids research 1992;20(20):5365-73.
1992: Muhlrad D; Hunter R; Parker R
A rapid method for localized mutagenesis of yeast genes.
Yeast (Chichester, England) 1992;8(2):79-82.

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