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Edward Parkin

Research Profile

Chemicals & Drugs

Anatomy

Concepts & Ideas

Disorders

Alzheimer's Disease

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Publications

TOP 3
D Katie Wilkinson; E Jane Turner; Edward T Parkin; Ashley E Garner; Penny J Harrison; Mark Crawford; Gordon W Stewart; Nigel M Hooper
Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis.
Edward T Parkin; Nicole T Watt; Ishrut Hussain; Elizabeth A Eckman; Christopher B Eckman; Jean C Manson; Herbert N Baybutt; Anthony J Turner; Nigel M Hooper
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Daniel W Lambert; Mike Yarski; Fiona J Warner; Paul Thornhill; Edward T Parkin; A Ian Smith; Nigel M Hooper; Anthony J Turner
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).

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All Publications

2008: D Katie Wilkinson; E Jane Turner; Edward T Parkin; Ashley E Garner; Penny J Harrison; Mark Crawford; Gordon W Stewart; Nigel M Hooper
Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis.
Biochimica et biophysica acta 2008;1778(1):125-32.
2007: Edward T Parkin; Nicole T Watt; Ishrut Hussain; Elizabeth A Eckman; Christopher B Eckman; Jean C Manson; Herbert N Baybutt; Anthony J Turner; Nigel M Hooper
Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(26):11062-7.
2005: Daniel W Lambert; Mike Yarski; Fiona J Warner; Paul Thornhill; Edward T Parkin; A Ian Smith; Nigel M Hooper; Anthony J Turner
Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2).
The Journal of biological chemistry 2005;280(34):30113-9.
2004: Edward T Parkin; Anthony J Turner; Nigel M Hooper
Secretase-mediated cell surface shedding of the angiotensin-converting enzyme.
Protein and peptide letters 2004;11(5):423-32.
2004: Tobias M J Allinson; Edward T Parkin; Thomas P Condon; Sylva L U Schwager; Edward D Sturrock; Anthony J Turner; Nigel M Hooper
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.
European journal of biochemistry / FEBS 2004;271(12):2539-47.
2004: Edward T Parkin; Nicole T Watt; Anthony J Turner; Nigel M Hooper
Dual mechanisms for shedding of the cellular prion protein.
The Journal of biological chemistry 2004;279(12):11170-8.
2003: Tobias M J Allinson; Edward T Parkin; Anthony J Turner; Nigel M Hooper
ADAMs family members as amyloid precursor protein alpha-secretases.
Journal of neuroscience research 2003;74(3):342-52.
2003: Edward T Parkin; Fulong Tan; Randal A Skidgel; Anthony J Turner; Nigel M Hooper
The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts.
Journal of cell science 2003;116(Pt 15):3079-87.
2002: Edward T Parkin; Alison Trew; Graham R Christie; Andrew Faller; Ruth Mayer; Anthony J Turner; Nigel M Hooper
Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha.
Biochemistry 2002;41(15):4972-81.
2002: R Elwyn Isaac; Edward T Parkin; Jeffrey N Keen; Dick R Nässel; Richard J Siviter; Alan D Shirras
Inactivation of a tachykinin-related peptide: identification of four neuropeptide-degrading enzymes in neuronal membranes of insects from four different orders.
Peptides 2002;23(4):725-33.
2001: Edward T Parkin; Anthony J Turner; Nigel M Hooper
Differential effects of glycosphingolipids on the detergent-insolubility of the glycosylphosphatidylinositol-anchored membrane dipeptidase.
The Biochemical journal 2001;358(Pt 1):209-16.
2001: Marwan Alfalah; Edward T Parkin; Ralf Jacob; Edward D Sturrock; R Mentele; Anthony J Turner; Nigel M Hooper; Hassan Y Naim
A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase.
The Journal of biological chemistry 2001;276(24):21105-9.
2000: Edward T Parkin; Anthony J Turner; Nigel M Hooper
Distribution of Presenilins and Amyloid Precursor Protein (APP) in Detergent-Insoluble Membrane Domains.
Methods in molecular medicine 2000;32():345-60.
2000: Nigel M Hooper; Alison Trew; Edward T Parkin; Anthony J Turner
The role of proteolysis in Alzheimer's disease.
Advances in experimental medicine and biology 2000;477():379-90.
1999: Edward T Parkin; Anthony J Turner; Nigel M Hooper
Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein.
The Biochemical journal 1999;344 Pt 1():23-30.
1999: Edward T Parkin; Ishrut Hussain; EH Karran; Anthony J Turner; Nigel M Hooper
Characterization of detergent-insoluble complexes containing the familial Alzheimer's disease-associated presenilins.
Journal of neurochemistry 1999;72(4):1534-43.
1998: Edward T Parkin; Anthony J Turner; Nigel M Hooper
Detergent solubility and processing of the familial Alzheimer's disease-related presenilin proteins.
Biochemical Society transactions 1998;26(3):S241.
1997: Edward T Parkin; Ishrut Hussain; Anthony J Turner; Nigel M Hooper
The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains.
Journal of neurochemistry 1997;69(5):2179-88.
1996: Edward T Parkin; Anthony J Turner; Nigel M Hooper
Isolation and characterization of two distinct low-density, Triton-insoluble, complexes from porcine lung membranes.
The Biochemical journal 1996;319 ( Pt 3)():887-96.
1996: Edward T Parkin; Anthony J Turner; Nigel M Hooper
A role for calcium and annexins in the formation of caveolae.
Biochemical Society transactions 1996;24(3):444S.