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Seppo Parkkila

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Anna-Kaisa Harju; Marianne Kuuslahti; Fatemeh Bootorabi; Claudiu T Supuran; Seppo Parkkila
Carbonic anhydrase III: a neglected isozyme is stepping into the limelight.
Aarre Kivelä; Aija Knuuttila; Jaromir Pastorek; Silvia Pastorekova; Jari Räsänen; Juha Saarnio; Kaisa Salmenkivi; Jarmo A Salo; Eero I T Sihvo; William S Sly; Abdul Waheed; Seppo Parkkila
Carbonic anhydrase IX in malignant pleural mesotheliomas: a potential target for anti-cancer therapy.
Martti E E Tolvanen; Maarit Patrikainen; Ashok Aspatwar; Harlan R Barker; Csaba Ortutay; Seppo Parkkila
Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes.

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2013: Anna-Kaisa Harju; Marianne Kuuslahti; Fatemeh Bootorabi; Claudiu T Supuran; Seppo Parkkila
Carbonic anhydrase III: a neglected isozyme is stepping into the limelight.
Journal of enzyme inhibition and medicinal chemistry 2013;28(2):231-9.
2013: Aarre Kivelä; Aija Knuuttila; Jaromir Pastorek; Silvia Pastorekova; Jari Räsänen; Juha Saarnio; Kaisa Salmenkivi; Jarmo A Salo; Eero I T Sihvo; William S Sly; Abdul Waheed; Seppo Parkkila
Carbonic anhydrase IX in malignant pleural mesotheliomas: a potential target for anti-cancer therapy.
Bioorganic & medicinal chemistry 2013;21(6):1483-8.
2013: Martti E E Tolvanen; Maarit Patrikainen; Ashok Aspatwar; Harlan R Barker; Csaba Ortutay; Seppo Parkkila
Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes.
Bioorganic & medicinal chemistry 2013;21(6):1503-10.
2013: Leo Syrjänen; Martti E E Tolvanen; Daniela Vullo; Fabrizio Carta; Mika Hilvo; Claudiu T Supuran; Seppo Parkkila
Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new α-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster.
Bioorganic & medicinal chemistry 2013;21(6):1516-21.
2013: Ashok Aspatwar; Sanna-Kaisa E Harjula; Eija Jokitalo; Csaba Ortutay; Mataleena Parikka; Mika Rämet; Martti E E Tolvanen; Mauno Vihinen; Seppo Parkkila
Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish.
Human molecular genetics 2013;22(3):417-32.
2013: Emma-Leena Alarmo; Kaija Holli; Heini Huhtala; Tarja Korhonen; Tuula Kuukasjärvi; Seppo Parkkila; Liisa Pylkkänen; Anne Kallioniemi
Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2013;26(1):10-21.
2012: Serdar Durdagi; Vesa P Hytönen; Niklas Kähkönen; Juha A Määttä; Peiwen Pan; Seppo Parkkila; Andrea Scozzafava; Daniela Vullo; Claudiu T Supuran
Protein-protein interactions: inhibition of mammalian carbonic anhydrases I-XV by the murine inhibitor of carbonic anhydrase and other members of the transferrin family.
Journal of medicinal chemistry 2012;55(11):5529-35.
2012: Seppo Parkkila; Andrea Scozzafava; Fabrizio Carta; Alfonso Maresca; Daniela Vullo; Claudiu T Supuran
Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.
Chemical communications (Cambridge, England) 2012;48(29):3551-3.
2012: Piritta Hynninen; Seppo Parkkila; Jaromir Pastorek; Silvia Pastorekova; William S Sly; Heini Huhtala; Abdul Waheed; Eija Tomas
Carbonic anhydrase isozymes II, IX, and XII in uterine tumors.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2012;120(2):117-29.
2012: Pei-wen Pan; Anna-Kaisa Parkkila; Salla Autio; Hannu Haapasalo; Mika Hilvo; Jaromir Pastorek; Silvia Pastorekova; Raija Sormunen; Seppo Parkkila
Brain phenotype of carbonic anhydrase IX-deficient mice.
Transgenic research 2012;21(1):163-76.
2011: David J Culp; Melanie N Cash; Thomas W Hussey; Pei-Wen Pan; Seppo Parkkila; Bently Robinson; Helen N Truong; Sarah L Gullett
Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva.
Biochimica et biophysica acta 2011;1812(12):1567-76.
2011: Fatemeh Bootorabi; Marianne Kuuslahti; Claudiu T Supuran; Jarkko Valjakka; Daniela Vullo; Onni Niemelä; Vesa P Hytönen; Janne Jänis; Seppo Parkkila
Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases.
Journal of enzyme inhibition and medicinal chemistry 2011;26(6):862-70.
2011: Veronika Tothova; Jorma Isola; Juraj Kopacek; Seppo Parkkila; Jaromir Pastorek; Silvia Pastorekova; Adriana Gibadulinova
Glucocorticoid receptor-mediated transcriptional activation of S100P gene coding for cancer-related calcium-binding protein.
Journal of cellular biochemistry 2011;112(11):3373-84.
2011: Marja Pertovaara; Amos Pasternack; Fatemeh Bootorabi; Marianne Kuuslahti; Seppo Parkkila
Novel carbonic anhydrase autoantibodies and renal manifestations in patients with primary Sjogren's syndrome.
Rheumatology (Oxford, England) 2011;50(8):1453-7.
2011: Pei-wen Pan; Katri Käyrä; Jukka Leinonen; Marja Nissinen; Seppo Parkkila; Hannu Rajaniemi
Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice.
Transgenic research 2011;20(3):675-98.
2011: Heini Kallio; Anne Kallioniemi; Sami Kilpinen; Eeva Laurila; Pei-wen Pan; Jaromir Pastorek; Silvia Pastorekova; Martti Tolvanen; Vilppu J Tuominen; Jarkko Valjakka; Jorma Isola; Janne Jänis; Seppo Parkkila
Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins.
PloS one 2011;6(11):e27152.
2010: Pei-wen Pan; Abdul Waheed; William S Sly; Seppo Parkkila
Carbonic anhydrases in the mouse harderian gland.
Journal of molecular histology 2010;41(6):411-7.
2010: Lina Baranauskienė; Mika Hilvo; Jurgita Matulienė; Dmitrij Golovenko; Elena Manakova; Virginija Dudutienė; Vilma Michailovienė; Jolanta Torresan; Jelena Jachno; Seppo Parkkila; Alfonso Maresca; Claudiu T Supuran; Saulius Gražulis; Daumantas Matulis
Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides.
Journal of enzyme inhibition and medicinal chemistry 2010;25(6):863-70.
2010: Anna Di Fiore; Emanuela Truppo; Claudiu T Supuran; vincenzo alterio; Nina Dathan; Fatemeh Bootorabi; Seppo Parkkila; Simona Maria Monti; Giuseppina De simone
Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide.
Bioorganic & medicinal chemistry letters 2010;20(17):5023-6.
2010: Fatemeh Bootorabi; Janne Jänis; Elona Smith; Abdul Waheed; Sampo Kukkurainen; Vesa Hytönen; Jarkko Valjakka; Claudiu T Supuran; Daniela Vullo; William S Sly; Seppo Parkkila
Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme.
Biochimie 2010;92(8):1072-80.
2010: Niku Oksala; Mari Levula; Markku Pelto-Huikko; Leena Kytömäki; Juhani T Soini; Juha Salenius; Mika Kähönen; Pekka J Karhunen; Reijo Laaksonen; Seppo Parkkila; Terho Lehtimäki
Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study.
Annals of medicine 2010;42(5):360-70.
2010: Calypse B Agborsangaya; Heljä-Marja Surcel; Adetunji T Toriola; Eero Pukkala; Seppo Parkkila; Pentti Tuohimaa; Annekatrin Lukanova; Matti Lehtinen
Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study.
European journal of cancer (Oxford, England : 1990) 2010;46(3):467-70.
2010: Claudia Temperini; Alessio Innocenti; Andrea Scozzafava; Seppo Parkkila; Claudiu T Supuran
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.
Journal of medicinal chemistry 2010;53(2):850-4.
2010: Janine Hallerdei; Renate J Scheibe; Seppo Parkkila; Abdul Waheed; William S Sly; Gerolf Gros; Petra Wetzel; Volker Endeward
T tubules and surface membranes provide equally effective pathways of carbonic anhydrase-facilitated lactic acid transport in skeletal muscle.
PloS one 2010;5(12):e15137.
2010: Ashok Aspatwar; Martti E E Tolvanen; Csaba Ortutay; Seppo Parkkila
Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer.
Current pharmaceutical design 2010;16(29):3264-76.
2010: Leo Syrjänen; Martti Tolvanen; Mika Hilvo; Ayodeji Olatubosun; Alessio Innocenti; Andrea Scozzafava; Jenni Leppiniemi; Barbara Niederhauser; Vesa P Hytönen; Thomas A Gorr; Seppo Parkkila; Claudiu T Supuran
Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates.
BMC biochemistry 2010;11():28.
2010: Heini Kallio; Mika Hilvo; Alejandra Rodriguez; Eeva-Helena Lappalainen; Anna-Maria Lappalainen; Seppo Parkkila
Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach.
BMC genomics 2010;11():397.
2010: Kristiina Nordfors; Joonas A Haapasalo; Miikka Korja; Anssi Niemelä; Jukka Laine; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila; Hannu Haapasalo
The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis.
BMC cancer 2010;10():148.
2010: Ashok Aspatwar; Martti Ee Tolvanen; Seppo Parkkila
Phylogeny and expression of carbonic anhydrase-related proteins.
BMC molecular biology 2010;11():25.
2010: Sina Saari; Mika Hilvo; Peiwen Pan; Gerolf Gros; Nina Hanke; Abdul Waheed; William S Sly; Seppo Parkkila
The most recently discovered carbonic anhydrase, CA XV, is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney.
PloS one 2010;5(3):e9624.
2010: Calypse Agborsangaya; Adetunji T Toriola; Kjell Grankvist; Heljä-Marja Surcel; Katsiaryna Holl; Seppo Parkkila; Pentti Tuohimaa; Annekatrin Lukanova; Matti Lehtinen
The effects of storage time and sampling season on the stability of serum 25-hydroxy vitamin D and androstenedione.
Nutrition and cancer 2010;62(1):51-7.
2009: vincenzo alterio; Mika Hilvo; Anna Di Fiore; Claudiu T Supuran; Peiwen Pan; Seppo Parkkila; Andrea Scaloni; Jaromir Pastorek; Silvia Pastorekova; Carlo Pedone; Andrea Scozzafava; Simona Maria Monti; Giuseppina De simone
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(38):16233-8.
2009: Seppo Parkkila; Alessio Innocenti; Heini Kallio; Mika Hilvo; Andrea Scozzafava; Claudiu T Supuran
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.
Bioorganic & medicinal chemistry letters 2009;19(15):4102-6.
2009: Alessio Innocenti; Mika Hilvo; Seppo Parkkila; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines.
Bioorganic & medicinal chemistry letters 2009;19(13):3430-3.
2009: Alessio Innocenti; Mika Hilvo; Seppo Parkkila; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
Bioorganic & medicinal chemistry letters 2009;19(4):1155-8.
2009: Mika Hilvo; Anna Maria Salzano; Alessio Innocenti; Markku S Kulomaa; Andrea Scozzafava; Andrea Scaloni; Seppo Parkkila; Claudiu T Supuran
Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
Journal of medicinal chemistry 2009;52(3):646-54.
2009: Alejandra Rodriguez; Tiina Luukkaala; Robert E Fleming; Robert S Britton; Bruce R Bacon; Seppo Parkkila
Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum.
PloS one 2009;4(9):e7212.
2009: Milla M Hänninen; Joonas Haapasalo; Hannu Haapasalo; Robert E Fleming; Robert S Britton; Bruce R Bacon; Seppo Parkkila
Expression of iron-related genes in human brain and brain tumors.
BMC neuroscience 2009;10():36.
2008: Anna Ohradanova; Katarina Gradin; Monika Barathova; Miriam Zatovicova; T Holotnakova; Juraj Kopacek; Seppo Parkkila; L Poellinger; Silvia Pastorekova; Jaromir Pastorek
Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2.
British journal of cancer 2008;99(8):1348-56.
2008: Ozlen Güzel; Alessio Innocenti; Andrea Scozzafava; Aydin Salman; Seppo Parkkila; Mika Hilvo; Claudiu T Supuran
Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides.
Bioorganic & medicinal chemistry 2008;16(20):9113-20.
2008: Mika Hilvo; Lina Baranauskiene; Anna Maria Salzano; Andrea Scaloni; Daumantas Matulis; Alessio Innocenti; Andrea Scozzafava; Simona Maria Monti; Anna Di Fiore; Giuseppina De Simone; Mikaela Lindfors; Janne Jänis; Jarkko Valjakka; Silvia Pastoreková; Jaromir Pastorek; Markku S Kulomaa; Henri R Nordlund; Claudiu T Supuran; Seppo Parkkila
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes.
The Journal of biological chemistry 2008;283(41):27799-809.
2008: Adriana Gibadulinova; Ingrid Oveckova; Seppo Parkkila; Silvia Pastorekova; Jaromir Pastorek
Key promoter elements involved in transcriptional activation of the cancer-related gene coding for S100P calcium-binding protein.
Oncology reports 2008;20(2):391-6.
2008: Alessio Innocenti; Mika Hilvo; Andrea Scozzafava; Seppo Parkkila; Claudiu T Supuran
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols.
Bioorganic & medicinal chemistry letters 2008;18(12):3593-6.
2008: Seppo Parkkila
Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches.
BJU international 2008;101 Suppl 4():16-21.
2008: Alessio Innocenti; Andrea Scozzafava; Seppo Parkkila; Luca Puccetti; Giuseppina De Simone; Claudiu T Supuran
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates.
Bioorganic & medicinal chemistry letters 2008;18(7):2267-71.
2008: Joonas Haapasalo; Mika Hilvo; Kristiina Nordfors; Hannu Haapasalo; Seppo Parkkila; Alise Hyrskyluoto; Immo Rantala; Abdul Waheed; William S Sly; Silvia Pastorekova; Jaromir Pastorek; Anna-Kaisa Parkkila
Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas.
Neuro-oncology 2008;10(2):131-8.
2008: Alessio Innocenti; Mika Hilvo; Andrea Scozzafava; Mikaela Lindfors; Henri R Nordlund; Markku S Kulomaa; Seppo Parkkila; Claudiu T Supuran
Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX.
Bioorganic & medicinal chemistry letters 2008;18(6):1898-903.
2008: Saman Warnakulasuriya; Seppo Parkkila; Toru Nagao; Victor R Preedy; Markku Pasanen; Heidi Koivisto; Onni Niemelä
Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2008;37(3):157-65.
2008: Mika Hilvo; A Innocenti; S M Monti; G De Simone; Claudiu T Supuran; Seppo Parkkila
Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV.
Current pharmaceutical design 2008;14(7):672-8.
2008: Seppo Parkkila; Pei-Wen Pan; Aoife Ward; Adriana Gibadulinova; Ingrid Oveckova; Silvia Pastorekova; Jaromir Pastorek; Alejandra Rodriguez Martinez; Henrik O Helin; Jorma Isola
The calcium-binding protein S100P in normal and malignant human tissues.
BMC clinical pathology 2008;8():2.
2008: Sally Järvelä; Seppo Parkkila; Helena Bragge; Marketta Kähkönen; Anna-Kaisa Parkkila; Ylermi Soini; Silvia Pastorekova; Jaromir Pastorek; Hannu Haapasalo
Carbonic anhydrase IX in oligodendroglial brain tumors.
BMC cancer 2008;8():1.
2007: Anssi M Niemelä; Piritta Hynninen; Jukka-Pekka Mecklin; Teijo Kuopio; Antti Kokko; Lauri Aaltonen; Anna-Kaisa Parkkila; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Torben F Orntoft; Mogens Kruhøffer; Hannu Haapasalo; Seppo Parkkila; Aarre Kivelä
Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007;16(9):1760-6.
2007: Max C Y Wong; Bernard Portmann; Roy Sherwood; Onni Niemela; Heidi Koivisto; Seppo Parkkila; Keith Trick; Mary R L'abbe; James Wilson; Philip R Dash; rajaventhan srirajaskanthan; Victor R Preedy; Helen Wiseman
The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver.
Metabolism: clinical and experimental 2007;56(7):865-75.
2007: Joonas Haapasalo; Kristiina Nordfors; Sally Järvelä; Helena Bragge; Immo Rantala; Anna-Kaisa Parkkila; Hannu Haapasalo; Seppo Parkkila
Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy.
Neuro-oncology 2007;9(3):308-13.
2007: Alejandra Rodriguez; Mika Hilvo; Leena Kytömäki; Robert E Fleming; Robert S Britton; Bruce R Bacon; Seppo Parkkila
Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse.
BMC genomics 2007;8():379.
2007: Mika Hilvo; Claudiu T Supuran; Seppo Parkkila
Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV.
Current topics in medicinal chemistry 2007;7(9):893-9.
2007: Pei-wen Pan; Alejandra Rodriguez; Seppo Parkkila
A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system.
BMC molecular biology 2007;8():22.
2007: Alejandra Rodriguez; Peiwen Pan; Seppo Parkkila
Expression studies of neogenin and its ligand hemojuvelin in mouse tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(1):85-96.
2006: Piritta Hynninen; Liisa Vaskivuo; Juha Saarnio; Hannu Haapasalo; Jyrki J. Kivelä; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S Sly; Ulla Puistola; Seppo Parkkila
Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours.
Histopathology 2006;49(6):594-602.
2006: Renate J Scheibe; Gerolf Gros; Seppo Parkkila; Abdul Waheed; Jeffrey H Grubb; Gul N Shah; William S Sly; Petra Wetzel
Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006;54(12):1379-91.
2006: Seppo Parkkila; Daniela Vullo; Luca Puccetti; Anna-Kaisa Parkkila; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines.
Bioorganic & medicinal chemistry letters 2006;16(15):3955-9.
2006: Heidi Koivisto; Johanna Hietala; Petra Anttila; Seppo Parkkila; Onni Niemelä
Long-term ethanol consumption and macrocytosis: diagnostic and pathogenic implications.
The Journal of laboratory and clinical medicine 2006;147(4):191-6.
2006: Peiwen Pan; Mari Leppilampi; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila
Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice.
The Journal of physiology 2006;571(Pt 2):319-27.
2006: Joonas A Haapasalo; Kristiina M Nordfors; Mika Hilvo; Immo J Rantala; Ylermi Soini; Anna-Kaisa Parkkila; Silvia Pastoreková; Jaromir Pastorek; Seppo Parkkila; Hannu Haapasalo
Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(2):473-7.
2006: Silvia Pastorekova; Seppo Parkkila; Jan Zavada
Tumor-associated carbonic anhydrases and their clinical significance.
Advances in clinical chemistry 2006;42():167-216.
2006: Heini Kallio; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Susanna Mannisto; Markku Heikinheimo; Seppo Parkkila
Expression of carbonic anhydrases IX and XII during mouse embryonic development.
BMC developmental biology 2006;6():22.
2006: Piia Halmi; Seppo Parkkila; Jari Honkaniemi
Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus.
Neurochemistry international 2006;48(1):24-30.
2005: Mika Hilvo; Martti Tolvanen; Amy Clark; bairong shen; Gul N Shah; Abdul Waheed; Piia Halmi; Milla Hänninen; Jonna M Hämäläinen; Mauno Vihinen; William S Sly; Seppo Parkkila
Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase.
The Biochemical journal 2005;392(Pt 1):83-92.
2005: Mari Leppilampi; Seppo Parkkila; Tuomo J Karttunen; Marta Gut; Gerolf Gros; Markus Sjöblom
Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(42):15247-52.
2005: Mari Leppilampi; Tuomo J Karttunen; Jyrki J. Kivelä; Marta Gut; Silvia Pastoreková; Jaromir Pastorek; Seppo Parkkila
Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C.
Transgenic research 2005;14(5):655-63.
2005: Thomas L Freeman; Dean J Tuma; Geoffrey M Thiele; Lynell W Klassen; Simon Worrall; Onni Niemelä; Seppo Parkkila; Peter W Emery; Victor R Preedy
Recent advances in alcohol-induced adduct formation.
Alcoholism, clinical and experimental research 2005;29(7):1310-6.
2005: Antti-J Kivela; Seppo Parkkila; Juha Saarnio; Tuomo J Karttunen; Jyrki Kivela; Anna-Kaisa Parkkila; Maria Bartosova; Vojtech Mucha; Michal Novak; Abdul Waheed; William S Sly; Hannu J Rajaniemi; Silvia Pastorekova; Jaromir Pastorek
Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa.
World journal of gastroenterology : WJG 2005;11(17):2616-25.
2005: Tanja Kleinke; Siegfried Wagner; Harald John; David Hewett-Emmett; Seppo Parkkila; Wolf-Georg Forssmann; Gerolf Gros
A distinct carbonic anhydrase in the mucus of the colon of humans and other mammals.
The Journal of experimental biology 2005;208(Pt 3):487-96.
2005: Aarre Kivelä; Jyrki J. Kivelä; Juha Saarnio; Seppo Parkkila
Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours.
World journal of gastroenterology : WJG 2005;11(2):155-63.
2005: Laura Kummola; Jonna M Hämäläinen; Jyrki J. Kivelä; Aarre Kivelä; Juha Saarnio; Tuomo J Karttunen; Seppo Parkkila
Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa.
BMC cancer 2005;5():41.
2005: Jokke Hannuksela; Mari Leppilampi; Keijo Peuhkurinen; Satu Kärkkäinen; Eija Saastamoinen; Tiina Heliö; Maija Kaartinen; Markku S Nieminen; Pentti Nieminen; Seppo Parkkila
Hereditary hemochromatosis gene (HFE) mutations C282Y, H63D and S65C in patients with idiopathic dilated cardiomyopathy.
European journal of heart failure 2005;7(1):103-8.
2004: Alejandra Rodriguez Martinez; Onni Niemelä; Seppo Parkkila
Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin.
Haematologica 2004;89(12):1441-5.
2004: Piritta Hynninen; Jonna M Hämäläinen; Silvia Pastorekova; Jaromir Pastorek; Abdul Waheed; William S Sly; Eija Tomas; Pertti Kirkinen; Seppo Parkkila
Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs.
Reproductive biology and endocrinology : RB&E 2004;2():73.
2004: Mika Hilvo; Monika Rafajová; Silvia Pastoreková; Jaromir Pastorek; Seppo Parkkila
Expression of carbonic anhydrase IX in mouse tissues.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004;52(10):1313-22.
2004: Jonna M Lehtonen; Seppo Parkkila; Daniela Vullo; Angela Casini; Andrea Scozzafava; Claudiu T Supuran
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design.
Bioorganic & medicinal chemistry letters 2004;14(14):3757-62.
2004: Silvia Pastorekova; Seppo Parkkila; Jaromir Pastorek; Claudiu T Supuran
Carbonic anhydrases: current state of the art, therapeutic applications and future prospects.
Journal of enzyme inhibition and medicinal chemistry 2004;19(3):199-229.
2004: Jaana Latvala; Seppo Parkkila; Onni Niemelä
Excess alcohol consumption is common in patients with cytopenia: studies in blood and bone marrow cells.
Alcoholism, clinical and experimental research 2004;28(4):619-24.
2004: Onni Niemelä; Seppo Parkkila
Alcoholic macrocytosis--is there a role for acetaldehyde and adducts?
Addiction biology 2004;9(1):3-10.
2004: Piia Halmi; Jonna Lehtonen; Abdul Waheed; William S Sly; Seppo Parkkila
Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2004;277(1):171-7.
2004: Jonna Lehtonen; bairong shen; Mauno Vihinen; Angela Casini; Andrea Scozzafava; Claudiu T Supuran; Anna-Kaisa Parkkila; Juha Saarnio; Aarre Kivelä; Abdul Waheed; William S Sly; Seppo Parkkila
Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family.
The Journal of biological chemistry 2004;279(4):2719-27.
2003: Onni Niemelä; Seppo Parkkila; Simon Worrall; Peter W Emery; Victor R Preedy
Generation of aldehyde-derived protein modifications in ethanol-exposed heart.
Alcoholism, clinical and experimental research 2003;27(12):1987-92.
2003: Miriam Zat'ovicová; Kvetoslava Tarábková; Eliska Svastová; Adriana Gibadulinová; Vojtech Mucha; Lýdia Jakubícková; Zuzana Biesová; Monika Rafajová; Marta Ortova Gut; Seppo Parkkila; Anna-Kaisa Parkkila; Abdul Waheed; Willam S Sly; Ivan Horak; Jaromir Pastorek; Silvia Pastoreková
Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX.
Journal of immunological methods 2003;282(1-2):117-34.
2003: Matti S Kyllönen; Seppo Parkkila; Hannu J Rajaniemi; Abdul Waheed; Jeffrey H Grubb; Gul N Shah; William S Sly; Kari Kaunisto
Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003;51(9):1217-24.
2003: Jyrki J. Kivelä; Merja Laine; Seppo Parkkila; Hannu J Rajaniemi
Salivary carbonic anhydrase VI and its relation to salivary flow rate and buffer capacity in pregnant and non-pregnant women.
Archives of oral biology 2003;48(8):547-51.
2003: Adrián Chrastina; Jan Závada; Seppo Parkkila; Stefan Kaluz; Milota Kaluzová; Július Rajcáni; Jaromir Pastorek; Silvia Pastoreková
Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma.
International journal of cancer. Journal international du cancer 2003;105(6):873-81.
2003: Mari Leppilampi; Juha Saarnio; Tuomo J Karttunen; Jyrki J. Kivelä; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila
Carbonic anhydrase isozymes IX and XII in gastric tumors.
World journal of gastroenterology : WJG 2003;9(7):1398-403.
2003: Jokke Hannuksela; Onni Niemelä; Mari Leppilampi; Anna-Kaisa Parkkila; Pirjo Koistinen; Pentti Nieminen; Seppo Parkkila
Clinical utility and outcome of HFE-genotyping in the search for hereditary hemochromatosis.
Clinica chimica acta; international journal of clinical chemistry 2003;331(1-2):61-7.
2003: Jokke Hannuksela; Seppo Parkkila; Abdul Waheed; Robert S Britton; Robert E Fleming; Bruce R Bacon; William S Sly
Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2.
European journal of haematology 2003;70(4):201-6.
2002: Marta Gut; Seppo Parkkila; Zdeòka Vernerová; Elvira Rohde; Jan Závada; Michael Höcker; Jaromir Pastorek; Tuomo J Karttunen; Adriana Gibadulinová; Zuzana Závadová; Klaus-Peter Knobeloch; Bertram Wiedenmann; Jan Svoboda; Ivan Horak; Silvia Pastoreková
Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9.
Gastroenterology 2002;123(6):1889-903.
2002: Onni Niemelä; Seppo Parkkila; Michael Koll; Victor R Preedy
Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II fibers in rats exposed to ethanol and the acetaldehyde dehydrogenase inhibitor cyanamide.
The American journal of clinical nutrition 2002;76(3):668-74.
2002: Charles H Halsted; Jesus A Villanueva; Angela M Devlin; Onni Niemelä; Seppo Parkkila; Timothy A Garrow; Lynn M Wallock; Mark K Shigenaga; Stepan Melnyk; S Jill James
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(15):10072-7.
2002: Mária Bartosová; Seppo Parkkila; Kamil Pohlodek; Tuomo J Karttunen; Stefan Galbavý; Vojtech Mucha; Adrian L Harris; Jaromir Pastorek; Silvia Pastoreková
Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2.
The Journal of pathology 2002;197(3):314-21.
2002: Mari Leppilampi; Pirjo Koistinen; Eeva-Riitta Savolainen; Jokke Hannuksela; Anna-Kaisa Parkkila; Onni Niemelä; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S Sly; Seppo Parkkila; Hannu J Rajaniemi
The expression of carbonic anhydrase II in hematological malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2240-5.
2002: Kari Kaunisto; Seppo Parkkila; Hannu J Rajaniemi; Abdul Waheed; Jeffrey H Grubb; William S Sly
Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification.
Kidney international 2002;61(6):2111-8.
2002: Seppo Parkkila; Aarre Kivelä; Kari Kaunisto; Anna-Kaisa Parkkila; Jukka Hakkola; Hannu J Rajaniemi; Abdul Waheed; William S Sly
The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV.
BMC gastroenterology 2002;2():13.
2002: Victor R Preedy; Junko Adachi; Migiwa Asano; Michael Koll; David Mantle; Onni Niemela; Seppo Parkkila; Alistair G Paice; Timothy Peters; Rajkumar Rajendram; Helmut Seitz; Yasuhiro Ueno; Simon Worrall
Free radicals in alcoholic myopathy: indices of damage and preventive studies.
Free radical biology & medicine 2002;32(8):683-7.
2002: Jokke Hannuksela; Eeva-Riitta Savolainen; Pirjo Koistinen; Seppo Parkkila
Prevalence of HFE genotypes, C282Y and H63D, in patients with hematologic disorders.
Haematologica 2002;87(2):131-5.
2001: Seppo Parkkila; Onni Niemelä; Robert S Britton; Robert E Fleming; A Waheed; Bruce R Bacon; William S Sly
Molecular aspects of iron absorption and HFE expression.
Gastroenterology 2001;121(6):1489-96.
2001: Jaana Latvala; J Melkko; Seppo Parkkila; Kimmo Järvi; K Makkonen; Onni Niemelä
Assays for acetaldehyde-derived adducts in blood proteins based on antibodies against acetaldehyde/lipoprotein condensates.
Alcoholism, clinical and experimental research 2001;25(11):1648-53.
2001: Juha Saarnio; Seppo Parkkila; Anna-Kaisa Parkkila; Silvia Pastoreková; Kari Haukipuro; Jaromir Pastorek; Tatu Juvonen; Tuomo J Karttunen
Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumours.
Journal of hepatology 2001;35(5):643-9.
2001: P Karhumaa; Jukka S Leinonen; Seppo Parkkila; Kari Kaunisto; Juha S Tapanainen; Hannu J Rajaniemi
The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11604-8.
2001: Simon Worrall; Onni Niemela; Seppo Parkkila; Timothy J Peters; Victor R Preedy
Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region.
European journal of clinical investigation 2001;31(8):723-30.
2001: P Karhumaa; Kari Kaunisto; Seppo Parkkila; Abdul Waheed; Silvia Pastoreková; Jaromir Pastorek; William S Sly; Hannu J Rajaniemi
Expression of the transmembrane carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts.
Molecular human reproduction 2001;7(7):611-6.
2001: Jaana Latvala; Seppo Parkkila; J Melkko; Onni Niemelä
Acetaldehyde adducts in blood and bone marrow of patients with ethanol-induced erythrocyte abnormalities.
Molecular medicine (Cambridge, Mass.) 2001;7(6):401-5.
2001: Seppo Parkkila; Onni Niemelä; Eeva-Riitta Savolainen; Pirjo Koistinen
HFE mutations do not account for transfusional iron overload in patients with acute myeloid leukemia.
Transfusion 2001;41(6):828-31.
2001: Victor R Preedy; Junko Adachi; Timothy J Peters; Simon Worrall; Seppo Parkkila; Onni Niemela; M Asamo; Yasuhiro Ueno; K Takeda; M Yamauchi; K Sakamoto; M Takagi; H Nakajima; G Toda
Recent advances in the pathology of alcoholic myopathy.
Alcoholism, clinical and experimental research 2001;25(5 Suppl ISBRA):54S-59S.
2001: Jukka S Leinonen; Seppo Parkkila; Kari Kaunisto; P Koivunen; Hannu J Rajaniemi
Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner's glands.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(5):657-62.
2001: K Makkonen; Katja Viitala; Seppo Parkkila; Onni Niemelä
Serum IgG and IgE antibodies against mold-derived antigens in patients with symptoms of hypersensitivity.
Clinica chimica acta; international journal of clinical chemistry 2001;305(1-2):89-98.
2001: Seppo Parkkila; Anna-Kaisa Parkkila; Hannu J Rajaniemi; Gul N Shah; Jeffrey H Grubb; Abdul Waheed; William S Sly
Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1918-23.
2000: Onni Niemelä; Seppo Parkkila; Risto O Juvonen; Katja Viitala; H V Gelboin; Markku Pasanen
Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases.
Journal of hepatology 2000;33(6):893-901.
2000: Seppo Parkkila; Anna-Kaisa Parkkila; Juha Saarnio; Jyrki J. Kivelä; Tuomo J Karttunen; Kari Kaunisto; Abdul Waheed; William S Sly; Ozlem Türeci; Ismo Virtanen; Hannu J Rajaniemi
Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(12):1601-8.
2000: Aarre Kivelä; Seppo Parkkila; Juha Saarnio; Tuomo J Karttunen; Jyrki J. Kivelä; Anna-Kaisa Parkkila; Silvia Pastoreková; Jaromir Pastorek; Abdul Waheed; William S Sly; Hannu J Rajaniemi
Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours.
Histochemistry and cell biology 2000;114(3):197-204.
2000: Jyrki Rintala; Pia Jaatinen; Seppo Parkkila; Maija Sarviharju; Kalervo Kiianmaa; Antti Hervonen; Onni Niemelä
Evidence of acetaldehyde-protein adduct formation in rat brain after lifelong consumption of ethanol.
Alcohol and alcoholism (Oxford, Oxfordshire) 2000;35(5):458-63.
2000: P Karhumaa; Seppo Parkkila; Abdul Waheed; Anna-Kaisa Parkkila; Kari Kaunisto; P W Tucker; C J Huang; William S Sly; Hannu J Rajaniemi
Nuclear NonO/p54(nrb) protein is a nonclassical carbonic anhydrase.
The Journal of biological chemistry 2000;275(21):16044-9.
2000: Seppo Parkkila; Anna-Kaisa Parkkila; Abdul Waheed; Robert S Britton; X Y Zhou; Robert E Fleming; Shunji Tomatsu; Bruce R Bacon; William S Sly
Cell surface expression of HFE protein in epithelial cells, macrophages, and monocytes.
Haematologica 2000;85(4):340-5.
2000: Seppo Parkkila; Hannu J Rajaniemi; Anna-Kaisa Parkkila; Jyrki Kivela; Abdul Waheed; Silvia Pastorekova; Jaromir Pastorek; William S Sly
Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(5):2220-4.
2000: Aarre Kivelä; Seppo Parkkila; Juha Saarnio; Tuomo J Karttunen; Jyrki J. Kivelä; Anna-Kaisa Parkkila; Abdul Waheed; William S Sly; Jeffrey H Grubb; G Shah; Ozlem Türeci; Hannu J Rajaniemi
Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors.
The American journal of pathology 2000;156(2):577-84.
2000: Jyrki J. Kivelä; Seppo Parkkila; Anna-Kaisa Parkkila; Hannu J Rajaniemi
[Carbonic anhydrases protect teeth and upper gastrointestinal mucosa].
Duodecim; lääketieteellinen aikakauskirja 2000;116(19):2105-9.
2000: Seppo Parkkila
[Hereditary hemochromatosis].
Duodecim; lääketieteellinen aikakauskirja 2000;116(8):829-36.
2000: Seppo Parkkila
An overview of the distribution and function of carbonic anhydrase in mammals.
EXS 2000;(90):79-93.
2000: Seppo Parkkila
Roles of carbonic anhydrases in the alimentary tract.
EXS 2000;(90):462-74.
2000: P Karhumaa; Seppo Parkkila; Ozlem Türeci; Abdul Waheed; Jeffrey H Grubb; G Shah; Anna-Kaisa Parkkila; Kari Kaunisto; Juha S Tapanainen; William S Sly; Hannu J Rajaniemi
Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium.
Molecular human reproduction 2000;6(1):68-74.
1999: Seppo Parkkila; Charles H Halsted; Jesus A Villanueva; H Kalervo Väänänen; Onni Niemelä
Expression of testosterone-dependent enzyme, carbonic anhydrase III, and oxidative stress in experimental alcoholic liver disease.
Digestive diseases and sciences 1999;44(11):2205-13.
1999: Jyrki Kivela; Seppo Parkkila; Anna-Kaisa Parkkila; Jukka S Leinonen; Hannu J Rajaniemi
Salivary carbonic anhydrase isoenzyme VI.
The Journal of physiology 1999;520 Pt 2():315-20.
1999: Onni Niemelä; Seppo Parkkila; Markku Pasanen; Katja Viitala; Jesus A Villanueva; Charles H Halsted
Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs.
Hepatology (Baltimore, Md.) 1999;30(4):1011-7.
1999: Onni Niemelä; Seppo Parkkila; Robert S Britton; E Brunt; Christine G Janney; Bruce R Bacon
Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury.
The Journal of laboratory and clinical medicine 1999;133(5):451-60.
1999: Jukka S Leinonen; Jyrki J. Kivelä; Seppo Parkkila; Anna-Kaisa Parkkila; Hannu J Rajaniemi
Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle.
Caries research 1999;33(3):185-90.
1999: Jyrki J. Kivelä; Seppo Parkkila; Anna-Kaisa Parkkila; Hannu J Rajaniemi
A low concentration of carbonic anhydrase isoenzyme VI in whole saliva is associated with caries prevalence.
Caries research 1999;33(3):178-84.
1999: Juha Saarnio; Seppo Parkkila; Anna-Kaisa Parkkila; Abdul Waheed; Tuomo J Karttunen; William S Sly
Cell-specific expression of mitochondrial carbonic anhydrase in the human and rat gastrointestinal tract.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(4):517-24.
1998: Onni Niemelä; Seppo Parkkila; Markku Pasanen; Yuji Iimuro; B Bradford; R G Thurman
Early alcoholic liver injury: formation of protein adducts with acetaldehyde and lipid peroxidation products, and expression of CYP2E1 and CYP3A.
Alcoholism, clinical and experimental research 1998;22(9):2118-24.
1998: Juha Saarnio; Seppo Parkkila; Anna-Kaisa Parkkila; Kari Haukipuro; Silvia Pastoreková; Jaromir Pastorek; MI Kairaluoma; Tuomo J Karttunen
Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation.
The American journal of pathology 1998;153(1):279-85.
1998: Juha Saarnio; Seppo Parkkila; Anna-Kaisa Parkkila; Abdul Waheed; M C Casey; X Y Zhou; Silvia Pastoreková; Jaromir Pastorek; Tuomo J Karttunen; Kari Haukipuro; MI Kairaluoma; William S Sly
Immunohistochemistry of carbonic anhydrase isozyme IX (MN/CA IX) in human gut reveals polarized expression in the epithelial cells with the highest proliferative capacity.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(4):497-504.
1997: Jyrki J. Kivelä; Seppo Parkkila; Abdul Waheed; Anna-Kaisa Parkkila; William S Sly; Hannu J Rajaniemi
Secretory carbonic anhydrase isoenzyme (CA VI) in human serum.
Clinical chemistry 1997;43(12):2318-22.
1997: Jyrki J. Kivelä; Seppo Parkkila; J Metteri; Anna-Kaisa Parkkila; A Toivanen; Hannu J Rajaniemi
Salivary carbonic anhydrase VI concentration and its relation to basic characteristics of saliva in young men.
Acta physiologica Scandinavica 1997;161(2):221-5.
1997: Anna-Kaisa Parkkila; Seppo Parkkila; M Reunanen; Onni Niemelä; Seppo Tuisku; I Rautakorpi; Hannu J Rajaniemi
Carbonic anhydrase II in the cerebrospinal fluid: its value as a disease marker.
European journal of clinical investigation 1997;27(5):392-7.
1997: Seppo Parkkila; Anna-Kaisa Parkkila; Juhani Lehtola; A Reinilä; H J Södervik; M Rannisto; Hannu J Rajaniemi
Salivary carbonic anhydrase protects gastroesophageal mucosa from acid injury.
Digestive diseases and sciences 1997;42(5):1013-9.
1997: Silvia Pastoreková; Seppo Parkkila; Anna-Kaisa Parkkila; R Opavský; Vladimír Zelník; Juha Saarnio; Jaromir Pastorek
Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts.
Gastroenterology 1997;112(2):398-408.