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Andrea Parmeggiani

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Andrea Parmeggiani; Poul Nissen
Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action.
Andrea Parmeggiani; Ivo M Krab; Sumio Okamura; Rikke C Nielsen; Jens Nyborg; Poul Nissen
Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
Andrea Parmeggiani; Ivo M Krab; Toshihiko Watanabe; Rikke C Nielsen; Caroline Dahlberg; Jens Nyborg; Poul Nissen
Enacyloxin IIa pinpoints a binding pocket of elongation factor Tu for development of novel antibiotics.

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All Publications

2006: Andrea Parmeggiani; Poul Nissen
Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action.
FEBS letters 2006;580(19):4576-81.
2006: Andrea Parmeggiani; Ivo M Krab; Sumio Okamura; Rikke C Nielsen; Jens Nyborg; Poul Nissen
Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu.
Biochemistry 2006;45(22):6846-57.
2006: Andrea Parmeggiani; Ivo M Krab; Toshihiko Watanabe; Rikke C Nielsen; Caroline Dahlberg; Jens Nyborg; Poul Nissen
Enacyloxin IIa pinpoints a binding pocket of elongation factor Tu for development of novel antibiotics.
The Journal of biological chemistry 2006;281(5):2893-900.
2004: Pieter H Anborgh; Sumio Okamura; Andrea Parmeggiani
Effects of the antibiotic pulvomycin on the elongation factor Tu-dependent reactions. Comparison with other antibiotics.
Biochemistry 2004;43(49):15550-6.
2002: Ivo M Krab; Andrea Parmeggiani
Mechanisms of EF-Tu, a pioneer GTPase.
Progress in nucleic acid research and molecular biology 2002;71():513-51.
2001: Ivo M Krab; Rob te Biesebeke; A Bernardi; Andrea Parmeggiani
Elongation factor Ts can act as a steric chaperone by increasing the solubility of nucleotide binding-impaired elongation factor-Tu.
Biochemistry 2001;40(29):8531-5.
2001: Rob te Biesebeke; Ivo M Krab; Andrea Parmeggiani
The arginine finger loop of yeast and human GAP is a determinant for the specificity toward Ras GTPase.
Biochemistry 2001;40(25):7474-9.
2001: C Giglione; S Gonfloni; Andrea Parmeggiani
Differential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25Mm.
European journal of biochemistry / FEBS 2001;268(11):3275-83.
2001: K Accorsi; C Giglione; Marco Vanoni; Andrea Parmeggiani
The Ras GDP/GTP cycle is regulated by oxidizing agents at the level of Ras regulators and effectors.
FEBS letters 2001;492(1-2):139-45.
2001: S Baouz; Eric Jacquet; K Accorsi; C Hountondji; Monica Balestrini; Renata Zippel; Emmapaola Sturani; Andrea Parmeggiani
Sites of phosphorylation by protein kinase A in CDC25Mm/GRF1, a guanine nucleotide exchange factor for Ras.
The Journal of biological chemistry 2001;276(3):1742-9.
2000: Jean-Bernard Créchet; Eric Jacquet; A Bernardi; Andrea Parmeggiani
Analysis of the role of the hypervariable region of yeast Ras2p and its farnesylation in the interaction with exchange factors and adenylyl cyclase.
The Journal of biological chemistry 2000;275(23):17754-61.
1999: Ivo M Krab; Andrea Parmeggiani
Mutagenesis of three residues, isoleucine-60, threonine-61, and aspartic acid-80, implicated in the GTPase activity of Escherichia coli elongation factor Tu.
Biochemistry 1999;38(40):13035-41.
1999: Ivo M Krab; Andrea Parmeggiani
Functional-structural analysis of threonine 25, a residue coordinating the nucleotide-bound magnesium in elongation factor Tu.
The Journal of biological chemistry 1999;274(16):11132-8.
1998: C Giglione; Andrea Parmeggiani
Raf-1 is involved in the regulation of the interaction between guanine nucleotide exchange factor and Ha-ras. Evidences for a function of Raf-1 and phosphatidylinositol 3-kinase upstream to Ras.
The Journal of biological chemistry 1998;273(52):34737-44.
1998: Ivo M Krab; Andrea Parmeggiani
EF-Tu, a GTPase odyssey.
Biochimica et biophysica acta 1998;1443(1-2):1-22.
1998: Jirí Jonák; Pieter H Anborgh; Andrea Parmeggiani
Interaction of EF-Tu with EF-Ts: substitution of His-118 in EF-Tu destabilizes the EF-Tu x EF-Ts complex but does not prevent EF-Ts from stimulating the release of EF-Tu-bound GDP.
FEBS letters 1998;422(2):189-92.
1998: Rengul Cetin-Atalay; Pieter H Anborgh; Robbert Cool; Andrea Parmeggiani
Functional role of the noncatalytic domains of elongation factor Tu in the interactions with ligands.
Biochemistry 1998;37(2):486-95.
1997: C Giglione; M C Parrini; S Baouz; A Bernardi; Andrea Parmeggiani
A new function of p120-GTPase-activating protein. Prevention of the guanine nucleotide exchange factor-stimulated nucleotide exchange on the active form of Ha-ras p21.
The Journal of biological chemistry 1997;272(40):25128-34.
1997: M C Parrini; C Giglione; Andrea Parmeggiani
Co-ordination and specificity of the action of GTPase-activating proteins and GDP/GTP-exchange factors on Ras.
Biochemical Society transactions 1997;25(3):997-1001.
1997: S Baouz; Eric Jacquet; A Bernardi; Andrea Parmeggiani
The N-terminal moiety of CDC25(Mm), a GDP/GTP exchange factor of Ras proteins, controls the activity of the catalytic domain. Modulation by calmodulin and calpain.
The Journal of biological chemistry 1997;272(10):6671-6.
1996: J B Créchet; A Bernardi; Andrea Parmeggiani
Distal switch II region of Ras2p is required for interaction with guanine nucleotide exchange factor.
The Journal of biological chemistry 1996;271(29):17234-40.
1996: Rengul Cetin-Atalay; Ivo M Krab; P H Anborgh; Robbert Cool; T Watanabe; T Sugiyama; K Izaki; Andrea Parmeggiani
Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome.
The EMBO journal 1996;15(10):2604-11.
1996: M C Parrini; A Bernardi; Andrea Parmeggiani
Determinants of Ras proteins specifying the sensitivity to yeast Ira2p and human p120-GAP.
The EMBO journal 1996;15(5):1107-11.
1995: Barend Kraal; L A Zeef; J R Mesters; Kathy Boon; E L Vorstenbosch; L Bosch; P H Anborgh; Andrea Parmeggiani; R Hilgenfeld
Antibiotic resistance mechanisms of mutant EF-Tu species in Escherichia coli.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1995;73(11-12):1167-77.
1995: M C Parrini; E Jacquet; A Bernardi; M Jacquet; Andrea Parmeggiani
Properties and regulation of the catalytic domain of Ira2p, a Saccharomyces cerevisiae GTPase-activating protein of Ras2p.
Biochemistry 1995;34(42):13776-83.
1995: E Jacquet; S Baouz; Andrea Parmeggiani
Characterization of mammalian C-CDC25Mm exchange factor and kinetic properties of the exchange reaction intermediate p21.C-CDC25Mm.
Biochemistry 1995;34(38):12347-54.
1995: Kathy Boon; I Krab; Andrea Parmeggiani; L Bosch; Barend Kraal
Substitution of Arg230 and Arg233 in Escherichia coli elongation factor Tu strongly enhances its pulvomycin resistance.
European journal of biochemistry / FEBS 1995;227(3):816-22.
1995: P Poullet; J B Créchet; A Bernardi; Andrea Parmeggiani
Properties of the catalytic domain of sdc25p, a yeast GDP/GTP exchange factor of Ras proteins. Complexation with wild-type Ras2p, [S24N]Ras2p and [R80D, N81D]Ras2p.
European journal of biochemistry / FEBS 1995;227(1-2):537-44.
1994: L A Zeef; L Bosch; P H Anborgh; Rengul Cetin-Atalay; Andrea Parmeggiani; R Hilgenfeld
Pulvomycin-resistant mutants of E.coli elongation factor Tu.
The EMBO journal 1994;13(21):5113-20.
1994: E Jacquet; M C Parrini; A Bernardi; Enzo Martegani; Andrea Parmeggiani
Properties of the catalytic domain of CDC25, a Saccharomyces cerevisiae GDP/GTP exchange factor: comparison of its activity on full-length and C-terminal truncated RAS2 proteins.
Biochemical and biophysical research communications 1994;199(2):497-503.
1993: J B Créchet; P Poullet; A Bernardi; O Fasano; Andrea Parmeggiani
Properties of the SDC25 C-domain, a GDP to GTP exchange factor of RAS proteins and in vitro modulation of adenylyl cyclase.
The Journal of biological chemistry 1993;268(20):14836-41.
1993: Emmanuelle Boy-Marcotte; A Buu; C Soustelle; P Poullet; Andrea Parmeggiani; Michel Jacquet
The C-terminal part of the CDC25 gene product has Ras-nucleotide exchange activity when present in a chimeric SDC25-CDC25 protein.
Current genetics 1993;23(5-6):397-401.
1992: E Jacquet; M Vanoni; C Ferrari; L Alberghina; Enzo Martegani; Andrea Parmeggiani
A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins.
The Journal of biological chemistry 1992;267(34):24181-3.
1992: K Harmark; P H Anborgh; M Merola; B F Clark; Andrea Parmeggiani
Substitution of aspartic acid-80, a residue involved in coordination of magnesium, weakens the GTP binding and strongly enhances the GTPase of the G domain of elongation factor Tu.
Biochemistry 1992;31(32):7367-72.
1992: M Y Mistou; E Jacquet; P Poullet; H Rensland; P Gideon; Ilme Schlichting; Alfred Wittinghofer; Andrea Parmeggiani
Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.
The EMBO journal 1992;11(7):2391-7.
1992: A Weijland; K Harmark; Robbert Cool; P H Anborgh; Andrea Parmeggiani
Elongation factor Tu: a molecular switch in protein biosynthesis.
Molecular microbiology 1992;6(6):683-8.
1992: M Y Mistou; Robbert Cool; Andrea Parmeggiani
Effects of ions on the intrinsic activities of c-H-ras protein p21. A comparison with elongation factor Tu.
European journal of biochemistry / FEBS 1992;204(1):179-85.
1991: P H Anborgh; Robbert Cool; F Gümüsel; K Harmark; E Jacquet; A Weijland; M Y Mistou; Andrea Parmeggiani
Structure-function relationships of elongation factor Tu as studied by mutagenesis.
Biochimie 1991;73(7-8):1051-9.
1990: K Harmark; Robbert Cool; B F Clark; Andrea Parmeggiani
The functional and structural roles of residues Gln114 and Glu117 in elongation factor Tu.
European journal of biochemistry / FEBS 1990;194(3):731-7.
1990: Barend Kraal; J M de Graaf; J R Mesters; P J van Hoof; E Jacquet; Andrea Parmeggiani
Fluoroaluminates do not affect the guanine-nucleotide binding centre of the peptide chain elongation factor EF-Tu.
European journal of biochemistry / FEBS 1990;192(2):305-9.
1990: F Gümüşel; Robbert Cool; A Weijland; P H Anborgh; Andrea Parmeggiani
Mutagenesis of the NH2-terminal domain of elongation factor Tu.
Biochimica et biophysica acta 1990;1050(1-3):215-21.
1990: J B Créchet; P Poullet; M Y Mistou; Andrea Parmeggiani; J Camonis; Emmanuelle Boy-Marcotte; F Damak; Michel Jacquet
Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25.
Science (New York, N.Y.) 1990;248(4957):866-8.
1990: J B Créchet; P Poullet; J Camonis; Michel Jacquet; Andrea Parmeggiani
Different kinetic properties of the two mutants, RAS2Ile152 and RAS2Val19, that suppress the CDC25 requirement in RAS/adenylate cyclase pathway in Saccharomyces cerevisiae.
The Journal of biological chemistry 1990;265(3):1563-8.
1987: G W Swart; Andrea Parmeggiani; Barend Kraal; L Bosch
Effects of the mutation glycine-222----aspartic acid on the functions of elongation factor Tu.
Biochemistry 1987;26(7):2047-54.
1984: F J Duisterwinkel; Barend Kraal; J M De Graaf; A Talens; L Bosch; G W Swart; Andrea Parmeggiani; T F La Cour; Jens Nyborg; Brian F C Clark
Specific alterations of the EF-Tu polypeptide chain considered in the light of its three-dimensional structure.
The EMBO journal 1984;3(1):113-20.
1982: G W Swart; Barend Kraal; L Bosch; Andrea Parmeggiani
Allosteric changes of the guanine nucleotide site of elongation factor EF-Tu: a comparative study of two kirromycin-resistant EF-Tu species.
FEBS letters 1982;142(1):101-6.