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John Parrington

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Anthony J Morgan; John Parrington; Siegfried K T Y Wagner; Grant C Churchill; Lianne C Davis; Alexander M Lewis; Antony Galione
Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.
Junaid Kashir; Bernadette Lemmon; Enda McVeigh; Ginny Mounce; John Parrington; Walaa M Ramadan; Karen Turner; Tim Child; Petra de Sutter; Bjorn Heindryckx; Celine Jones; Kevin Coward
Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability.
Lianne C Davis; Duncan Bloor-Young; Vincenzo Cerundolo; Ji-Li Chen; Grant C Churchill; Stuart J Conway; Anthony J Morgan; John Parrington; Eugene Shenderov; Charlotte M Snead; Megan N Stanton-Humphreys; Antony Galione
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.

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All Publications

2013: Anthony J Morgan; John Parrington; Siegfried K T Y Wagner; Grant C Churchill; Lianne C Davis; Alexander M Lewis; Antony Galione
Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles.
The Journal of cell biology 2013;200(6):789-805.
2013: Junaid Kashir; Bernadette Lemmon; Enda McVeigh; Ginny Mounce; John Parrington; Walaa M Ramadan; Karen Turner; Tim Child; Petra de Sutter; Bjorn Heindryckx; Celine Jones; Kevin Coward
Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability.
Fertility and sterility 2013;99(1):107-17.
2012: Lianne C Davis; Duncan Bloor-Young; Vincenzo Cerundolo; Ji-Li Chen; Grant C Churchill; Stuart J Conway; Anthony J Morgan; John Parrington; Eugene Shenderov; Charlotte M Snead; Megan N Stanton-Humphreys; Antony Galione
NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing.
Current biology : CB 2012;22(24):2331-7.
2012: Anthony J Morgan; John Parrington; Antony Galione
The luminal Ca(2+) chelator, TPEN, inhibits NAADP-induced Ca(2+) release.
Cell calcium 2012;52(6):481-7.
2012: Junaid Kashir; Michalis Konstantinidis; John Parrington; Dagan Wells; Petra De Sutter; Bjorn Heindryckx; Celine Jones; Kevin Coward
Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells.
Fertility and sterility 2012;98(2):423-31.
2012: J Kashir; John Parrington; P De Sutter; B Heindryckx; C Jones; K Coward
A sperm's tail: the need to consider temporal aspects of specific physiological mechanisms during and following gamete fusion.
Human reproduction (Oxford, England) 2012;27(2):625-6.
2012: Timothy F Walseth; Antony Galione; Pooja Jain; Yaping Lin-Moshier; Jonathan S Marchant; John Parrington; Margarida Ruas; James T Slama
Photoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin egg.
The Journal of biological chemistry 2012;287(4):2308-15.
2011: Junaid Kashir; Hoi-Chang Lee; Dimitra Nikiforaki; John Parrington; Katja Rietdorf; Margarida Ruas; Sze Tian Tee; Petra De Sutter; Claire Durrans; Rafael A Fissore; Antony Galione; Bjorn Heindryckx; Celine Jones; Kevin Coward
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.
Human reproduction (Oxford, England) 2011;26(12):3372-87.
2011: Katja Rietdorf; Margarida Ruas; Tim M Funnell; Jennifer Heinemann; John Parrington; Antony Galione
Two-pore channels form homo- and heterodimers.
The Journal of biological chemistry 2011;286(43):37058-62.
2011: Antony Galione; John Parrington; Tim Funnell
Physiological roles of NAADP-mediated Ca2+ signaling.
Science China. Life sciences 2011;54(8):725-32.
2011: Junaid Kashir; John Parrington; Karen Turner; Jo Craig; Claire Durrans; Joaquín Gadea; Ariane Heynen; Celine Jones; Kevin Coward
Effects of cryopreservation and density-gradient washing on phospholipase C zeta concentrations in human spermatozoa.
Reproductive biomedicine online 2011;23(2):263-7.
2011: John Parrington; Kevin Coward; Joaquín Gadea
Sperm and testis mediated DNA transfer as a means of gene therapy.
Systems biology in reproductive medicine 2011;57(1-2):35-42.
2010: Antony Galione; Anthony J Morgan; Abdelilah Arredouani; Lianne C Davis; Katja Rietdorf; Margarida Ruas; John Parrington
NAADP as an intracellular messenger regulating lysosomal calcium-release channels.
Biochemical Society transactions 2010;38(6):1424-31.
2010: Abdelilah Arredouani; A Mark Evans; Jianjie Ma; John Parrington; Michael X Zhu; Antony Galione
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.
Islets 2010;2(5):323-30.
2010: Nezahat Tugba Durlu-Kandilci; Margarida Ruas; Kai-Ting Chuang; Alison Brading; John Parrington; Antony Galione
TPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscle.
The Journal of biological chemistry 2010;285(32):24925-32.
2010: Margarida Ruas; John A Ward; Keiko Watanabe; Gary M Wessel; Michael X Zhu; Abdelilah Arredouani; Xiaotong Cheng; Grant C Churchill; Lianne C Davis; Timothy M Funnell; Heidi Koegel; Emyr Lloyd-Evans; Anthony J Morgan; John Parrington; Frances M Platt; Katja Rietdorf; Antony Galione
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.
Current biology : CB 2010;20(8):703-9.
2009: Antony Galione; A Mark Evans; Jianjie Ma; John Parrington; Abdelilah Arredouani; Xiaotong Cheng; Michael X Zhu
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
Pflügers Archiv : European journal of physiology 2009;458(5):869-76.
2009: Claire Young; Patricia Grasa; Kevin Coward; Lianne C Davis; John Parrington
Phospholipase C zeta undergoes dynamic changes in its pattern of localization in sperm during capacitation and the acrosome reaction.
Fertility and sterility 2009;91(5 Suppl):2230-42.
2008: Sook-Young Yoon; Teru Jellerette; Ana Maria Salicioni; Hoi-Chang Lee; Myung-Sik Yoo; Kevin Coward; John Parrington; Daniel Grow; Jose B Cibelli; Pablo E Visconti; Jesse Mager; Rafael A Fissore
Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development.
The Journal of clinical investigation 2008;118(11):3671-81.
2008: P Grasa; Kevin Coward; C Young; John Parrington
The pattern of localization of the putative oocyte activation factor, phospholipase Czeta, in uncapacitated, capacitated, and ionophore-treated human spermatozoa.
Human reproduction (Oxford, England) 2008;23(11):2513-22.
2008: Lianne C Davis; Anthony J Morgan; Margarida Ruas; Julian L Wong; Richard M Graeff; Albert J Poustka; Hon Cheung Lee; Gary M Wessel; John Parrington; Antony Galione
Ca(2+) signaling occurs via second messenger release from intraorganelle synthesis sites.
Current biology : CB 2008;18(20):1612-8.
2007: John Parrington; Lianne C Davis; Antony Galione; Gary Wessel
Flipping the switch: how a sperm activates the egg at fertilization.
Developmental dynamics : an official publication of the American Association of Anatomists 2007;236(8):2027-38.
2007: Paul A D Mattick; John Parrington; Efe Odia; Alasdair Simpson; Thomas Collins; Derek A Terrar
Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current.
The Journal of physiology 2007;582(Pt 3):1195-203.
2007: Kevin Coward; Hiroki Kubota; John Parrington
In vivo gene transfer into testis and sperm: developments and future application.
Archives of andrology 2007;53(4):187-97.
2007: Kevin Coward; Helen Owen; Richard Tunwell; Karl Swann; John Parrington
Phospholipid binding properties and functional characterization of a sea urchin phospholipase Cdelta in urchin and mouse eggs.
Biochemical and biophysical research communications 2007;357(4):964-70.
2007: John Parrington; Kevin Coward; Olivia Hibbitt; Hiroki Kubota; C Young; J McIlhinney; O Jones
In vivo gene transfer into the testis by electroporation and viral infection--a novel way to study testis and sperm function.
Society of Reproduction and Fertility supplement 2007;65():469-74.
2006: Kevin Coward; Hiroki Kubota; Olivia Hibbitt; Jeff McIlhinney; Kenjiro Kohri; John Parrington
Expression of a fluorescent recombinant form of sperm protein phospholipase C zeta in mouse epididymal sperm by in vivo gene transfer into the testis.
Fertility and sterility 2006;85 Suppl 1():1281-9.
2006: Olivia Hibbitt; Kevin Coward; Hiroki Kubota; Nilendran Prathalingham; William Holt; Kenjiro Kohri; John Parrington
In vivo gene transfer by electroporation allows expression of a fluorescent transgene in hamster testis and epididymal sperm and has no adverse effects upon testicular integrity or sperm quality.
Biology of reproduction 2006;74(1):95-101.
2005: Kevin Coward; C P Ponting; H-Y Chang; Olivia Hibbitt; P Savolainen; Keith T Jones; John Parrington
Phospholipase Czeta, the trigger of egg activation in mammals, is present in a non-mammalian species.
Reproduction (Cambridge, England) 2005;130(2):157-63.
2005: Hiroki Kubota; Yutaro Hayashi; Yasue Kubota; Kevin Coward; John Parrington
Comparison of two methods of in vivo gene transfer by electroporation.
Fertility and sterility 2005;83 Suppl 1():1310-8.
2004: Antony Galione; John Parrington; James Dowden
The NAADP receptor: commentary on Billington et al.
British journal of pharmacology 2004;142(8):1203-7.
2004: Kevin Coward; Helen Owen; Albert J Poustka; Olivia Hibbitt; Richard Tunwell; Hiroki Kubota; Karl Swann; John Parrington
Cloning of a novel phospholipase C-delta isoform from pacific purple sea urchin (Strongylocentrotus purpuratus) gametes and its expression during early embryonic development.
Biochemical and biophysical research communications 2004;313(4):894-901.
2003: Kevin Coward; Antonio Campos-Mendoza; Mark G Larman; Olivia Hibbitt; Brendan McAndrew; Niall Bromage; John Parrington
Teleost fish spermatozoa contain a cytosolic protein factor that induces calcium release in sea urchin egg homogenates and triggers calcium oscillations when injected into mouse oocytes.
Biochemical and biophysical research communications 2003;305(2):299-304.
2003: John Parrington; Kevin Coward
The spark of life.
Biologist (London, England) 2003;50(1):5-10.
2002: Georgina Berridge; George Dickinson; John Parrington; Antony Galione; Sandip Patel
Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate.
The Journal of biological chemistry 2002;277(46):43717-23.
2002: Christopher M Saunders; Mark G Larman; John Parrington; Llewellyn J Cox; Jillian Royse; Lynda M Blayney; Karl Swann; F Anthony Lai
PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development.
Development (Cambridge, England) 2002;129(15):3533-44.
2002: John Parrington; M L Jones; Richard Tunwell; Christelle Devader; M Katan; Karl Swann
Phospholipase C isoforms in mammalian spermatozoa: potential components of the sperm factor that causes Ca2+ release in eggs.
Reproduction (Cambridge, England) 2002;123(1):31-9.
2001: Karl Swann; John Parrington; Keith T Jones
Potential role of a sperm-derived phospholipase C in triggering the egg-activating Ca2+ signal at fertilization.
Reproduction (Cambridge, England) 2001;122(6):839-46.
2001: John Parrington
Does a soluble sperm factor trigger calcium release in the egg at fertilization?
Journal of andrology 2001;22(1):1-11.
2000: A Rice; John Parrington; Keith T Jones; Karl Swann
Mammalian sperm contain a Ca(2+)-sensitive phospholipase C activity that can generate InsP(3) from PIP(2) associated with intracellular organelles.
Developmental biology 2000;228(1):125-35.
2000: John Parrington; F Anthony Lai; Karl Swann
The soluble mammalian sperm factor protein that triggers Ca2+ oscillations in eggs: evidence for expression of mRNA(s) coding for sperm factor protein(s) in spermatogenic cells.
Biology of the cell / under the auspices of the European Cell Biology Organization 2000;92(3-4):267-75.
2000: Keith T Jones; M Matsuda; John Parrington; M Katan; Karl Swann
Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs.
The Biochemical journal 2000;346 Pt 3():743-9.
1999: Karl Swann; John Parrington
Mechanism of Ca2+ release at fertilization in mammals.
The Journal of experimental zoology 1999;285(3):267-75.
1999: John Parrington; Keith T Jones; A Lai; Karl Swann
The soluble sperm factor that causes Ca2+ release from sea-urchin (Lytechinus pictus) egg homogenates also triggers Ca2+ oscillations after injection into mouse eggs.
The Biochemical journal 1999;341 ( Pt 1)():1-4.
1998: John Parrington; S Brind; H De Smedt; R Gangeswaran; F Anthony Lai; R Wojcikiewicz; John Carroll
Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.
Developmental biology 1998;203(2):451-61.
1998: Karl Swann; John Parrington; Keith T Jones
On the search for the sperm oscillogen.
Molecular human reproduction 1998;4(11):1010-2.
1998: Keith T Jones; C Cruttwell; John Parrington; Karl Swann
A mammalian sperm cytosolic phospholipase C activity generates inositol trisphosphate and causes Ca2+ release in sea urchin egg homogenates.
FEBS letters 1998;437(3):297-300.
1998: V Shevchenko; M Hogben; R Ekong; John Parrington; F Anthony Lai
The human glucosamine-6-phosphate deaminase gene: cDNA cloning and expression, genomic organization and chromosomal localization.
Gene 1998;216(1):31-8.
1998: M Hogben; John Parrington; V Shevchenko; Karl Swann; F Anthony Lai
Calcium oscillations, sperm factors and egg activation at fertilisation.
Journal of molecular medicine (Berlin, Germany) 1998;76(8):548-54.
1998: Markus Montag; John Parrington; Karl Swann; F Anthony Lai; Hans van der Ven
Presence and localization of oscillin in human spermatozoa in relation to the integrity of the sperm membrane.
FEBS letters 1998;423(3):357-61.
1998: John Parrington; F Anthony Lai; Karl Swann
A novel protein for Ca2+ signaling at fertilization.
Current topics in developmental biology 1998;39():215-43.
1996: A T Thein; X Han; E Heyderman; M Fox; S J Steele; John Parrington
Molecular cytogenetic analysis of five newly established cervical cancer cell lines using G banding and fluorescence in situ hybridization.
Cancer genetics and cytogenetics 1996;91(1):28-36.
1996: Jon K Sherlock; D K Griffin; J D A Delhanty; John Parrington
Homologies between human and marmoset (Callithrix jacchus) chromosomes revealed by comparative chromosome painting.
Genomics 1996;33(2):214-9.
1996: Richard Festenstein; Mauro Tolaini; P Corbella; Clio Mamalaki; John Parrington; M Fox; A Miliou; M Jones; Dimitris Kioussis
Locus control region function and heterochromatin-induced position effect variegation.
Science (New York, N.Y.) 1996;271(5252):1123-5.
1996: John Parrington; Karl Swann; V I Shevchenko; A K Sesay; F Anthony Lai
Calcium oscillations in mammalian eggs triggered by a soluble sperm protein.
Nature 1996;379(6563):364-8.
1996: C P Berrie; K S Cuthbertson; John Parrington; F Anthony Lai; Karl Swann
A cytosolic sperm factor triggers calcium oscillations in rat hepatocytes.
The Biochemical journal 1996;313 ( Pt 2)():369-72.
1995: R M al-Jehani; D Wells; M Fox; John Parrington
Correlation of loss of heterozygosity with cytogenetic analysis using G-banding and fluorescence in situ hybridization in aneuploid cultures from two human testicular germ-cell tumors.
Cancer genetics and cytogenetics 1995;85(1):26-36.
1995: R M al-Jehani; Sue Povey; J D A Delhanty; John Parrington
Loss of heterozygosity on chromosome arms 5q, 11p, 11q, 13q, and 16p in human testicular germ cell tumors.
Genes, chromosomes & cancer 1995;13(4):249-56.
1994: John Parrington; L F West; E Heyderman
Chromosome analysis of parallel short-term cultures from four testicular germ-cell tumors.
Cancer genetics and cytogenetics 1994;75(2):90-102.
1988: J D A Delhanty; John Parrington
The origin of isochromosomes.
Clinical genetics 1988;34(3):207-8.
1988: K Tsioupra; L F West; M B Davis; John Parrington; J D A Delhanty
Spontaneous and induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members.
Disease markers 1988;6(2):127-32.
1987: John Parrington; L F West; Sue Povey
Loss of heterozygosity in hypotriploid cell cultures from testicular tumours.
Human genetics 1987;77(3):269-76.
1985: I Santisteban; Sue Povey; L F West; John Parrington; David A Hopkinson
Chromosome assignment, biochemical and immunological studies on a human aldehyde dehydrogenase, ALDH3.
Annals of human genetics 1985;49(Pt 2):87-100.
1985: Yvonne H Edwards; M Parkar; Sue Povey; L F West; John Parrington; E Solomon
Human myosin heavy chain genes assigned to chromosome 17 using a human cDNA clone as probe.
Annals of human genetics 1985;49(Pt 2):101-9.
1984: John Parrington; L F West; Sue Povey
The origin of ovarian teratomas.
Journal of medical genetics 1984;21(1):4-12.
1981: J D A Delhanty; John Parrington; G Casey; J Attwood; L West; D Kirk; G Corney
Growth, DNA repair, sister chromatid exchange and chromosome studies in fibroblasts from Huntington's disease patients.
Annals of human genetics 1981;45(Pt 2):181-98.