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William Parsons

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S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl pyrazoles as sodium channel blockers.

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All Publications

2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Ronsar Eid; Michael H Fisher; William H Parsons; Matthew J Wyvratt; Kathryn A Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; Ann Weber; Joseph L Duffy
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
Bioorganic & medicinal chemistry letters 2010;20(24):7479-82.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5536-40.
2010: S Tyagarajan; Prasun K Chakravarty; Bishan Zhou; Brett Taylor; Michael H Fisher; Matthew J Wyvratt; Kathy Lyons; Tracy Klatt; Xiaohua Li; Sanjeev Kumar; Brande Williams; John Felix; Birgit T Priest; Richard Brochu; Vivien A Warren; McHardy Smith; Maria Garcia; Gregory J Kaczorowski; William J Martin; Catherine Abbadie; Erin McGowan; Nina Jochnowitz; William H Parsons
Substituted biaryl pyrazoles as sodium channel blockers.
Bioorganic & medicinal chemistry letters 2010;20(18):5480-3.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2009;19(18):5334-8.
2009: Pengcheng P Shao; Feng Ye; Ann E Weber; Xiaohua Li; Kathryn A Lyons; William H Parsons; Maria L Garcia; Birgit T Priest; McHardy Smith; John P Felix; Brande S Williams; Gregory J Kaczorowski; Erin McGowan; Catherine Abbadie; William J Martin; Daniel R McMasters; Ying-Duo Gao
Discovery of a novel class of isoxazoline voltage gated sodium channel blockers.
Bioorganic & medicinal chemistry letters 2009;19(18):5329-33.
2008: Scott B Hoyt; Clare London; Matthew J Wyvratt; Michael H Fisher; Doreen E Cashen; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; D Euan MacIntyre; William J Martin; Birgit T Priest; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
3-Amino-1,5-benzodiazepinones: potent, state-dependent sodium channel blockers with anti-epileptic activity.
Bioorganic & medicinal chemistry letters 2008;18(6):1963-6.
2008: Clare London; Scott B Hoyt; William H Parsons; Brande S Williams; Vivien A Warren; Richard A Tschirret-Guth; McHardy Smith; Birgit T Priest; Erin McGowan; William J Martin; Kathryn A Lyons; Xiaohua Li; Bindhu V Karanam; Nina Jochnowitz; Maria L Garcia; John P Felix; Brian Dean; Catherine Abbadie; Gregory J Kaczorowski; Joseph L Duffy
Imidazopyridines: a novel class of hNav1.7 channel blockers.
Bioorganic & medicinal chemistry letters 2008;18(5):1696-701.
2007: Brande S Williams; John P Felix; Birgit T Priest; Richard Brochu; Kefei Dai; Scott B Hoyt; Clare London; Yui S Tang; Joseph L Duffy; William H Parsons; Gregory J Kaczorowski; Maria L Garcia
Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7.
Biochemistry 2007;46(50):14693-703.
2007: Scott B Hoyt; Clare London; Hyun O Ok; Edward Gonzalez; Joseph L Duffy; Catherine Abbadie; Brian Dean; John P Felix; Maria L Garcia; Nina Jochnowitz; Bindhu V Karanam; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; McHardy Smith; Richard A Tschirret-Guth; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Benzazepinone Nav1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(22):6172-7.
2007: Scott B Hoyt; Clare London; David J. Gorin; Matthew J Wyvratt; Michael H Fisher; Catherine Abbadie; John P Felix; Maria L Garcia; Xiaohua Li; Kathryn A Lyons; Erin McGowan; D Euan MacIntyre; William J Martin; Birgit T Priest; Amy Ritter; McHardy Smith; Vivien A Warren; Brande S Williams; Gregory J Kaczorowski; William H Parsons
Discovery of a novel class of benzazepinone Na(v)1.7 blockers: potential treatments for neuropathic pain.
Bioorganic & medicinal chemistry letters 2007;17(16):4630-4.
2007: Gabor Butora; Richard Jiao; William H Parsons; Pasquale P Vicario; Hong Jin; Julia Ayala; Margaret A Cascieri; Lihu Yang
3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2.
Bioorganic & medicinal chemistry letters 2007;17(13):3636-41.
2007: Lihu Yang; Gabor Butora; Richard X Jiao; Alexander Pasternak; Changyou Zhou; William H Parsons; Sander G Mills; Pasquale P Vicario; Julia Ayala; Margaret A Cascieri; Malcolm MacCoss
Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.
Journal of medicinal chemistry 2007;50(11):2609-11.
2007: Changyou Zhou; Liangqin Guo; William H Parsons; Sander G Mills; Malcolm MacCoss; Pasquale P Vicario; Hans Zweerink; Margaret A Cascieri; Martin S Springer; Lihu Yang
Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists.
Bioorganic & medicinal chemistry letters 2007;17(2):309-14.
2006: Gabor Butora; Gregori J Morriello; Shankaran Kothandaraman; Deodialsingh Guiadeen; Alexander Pasternak; William H Parsons; Malcolm MacCoss; Pasquale P Vicario; Margaret A Cascieri; Lihu Yang
4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 2006;16(18):4715-22.
2006: Alexander Pasternak; Dominick Marino; Pasquale P Vicario; Julia Ayala; Margaret A Cascierri; William H Parsons; Sander G Mills; Malcolm MacCoss; Lihu Yang
Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.
Journal of medicinal chemistry 2006;49(16):4801-4.
2006: Lihu Yang; Changyou Zhou; Liangqin Guo; Gregori J Morriello; Gabor Butora; Alexander Pasternak; William H Parsons; Sander G Mills; Malcolm MacCoss; Pasquale P Vicario; Hans Zweerink; Julia Ayala; Shefali Goyal; William A Hanlon; Margaret A Cascieri; Martin S Springer
Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.
Bioorganic & medicinal chemistry letters 2006;16(14):3735-9.
2006: Dong Ok; Chunshi Li; Catherine Abbadie; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; William J Martin; Birgit T Priest; McHardy Smith; Brande S Williams; Matthew J Wyvratt; William H Parsons
Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers.
Bioorganic & medicinal chemistry letters 2006;16(5):1358-61.
2006: Richard Brochu; Ivy E Dick; Jason W Tarpley; Erin McGowan; David Gunner; James Herrington; Pengcheng P Shao; Dong Ok; Chunshi Li; William H Parsons; Gary L Stump; christopher regan; Joseph J Lynch; Kathryn A Lyons; Owen B McManus; Samantha Clark; Zahid Ali; Gregory J Kaczorowski; William J Martin; Birgit T Priest
Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.
Molecular pharmacology 2006;69(3):823-32.
2005: Jun Liang; Richard Brochu; charles cohen; Ivy E Dick; John P Felix; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Kathryn A Lyons; Peter T Meinke; Birgit T Priest; william Schmalhofer; McHardy Smith; Jason W Tarpley; Brande S Williams; William J Martin; William H Parsons
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(11):2943-7.
2005: Pengcheng P Shao; Dong Ok; Michael H Fisher; Maria L Garcia; Gregory J Kaczorowski; Chunshi Li; Kathryn A Lyons; William J Martin; Peter T Meinke; Birgit T Priest; McHardy Smith; Matthew J Wyvratt; Feng Ye; William H Parsons
Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain.
Bioorganic & medicinal chemistry letters 2005;15(7):1901-7.
2005: Jianming Bao; Shouwu Miao; Frank Kayser; Andrew Kotliar; Robert K Baker; George A Doss; John P Felix; Randal M Bugianesi; Robert S Slaughter; Gregory J Kaczorowski; Maria L Garcia; Sookhee N Ha; Laurie A Castonguay; Gloria C Koo; Kashmira Shah; Martin S Springer; Mary Jo Staruch; William H Parsons; Kathleen M Rupprecht
Potent Kv1.3 inhibitors from correolide-modification of the C18 position.
Bioorganic & medicinal chemistry letters 2005;15(2):447-51.
2004: Birgit T Priest; Maria L Garcia; Richard E Middleton; Richard Brochu; Samantha Clark; Ge Dai; Ivy E Dick; John P Felix; Chou J Liu; Brita S Reiseter; william Schmalhofer; Pengcheng P Shao; Yui S Tang; Margaret Z Chou; Martin G Kohler; McHardy Smith; Vivien A Warren; Brande S Williams; charles cohen; William J Martin; Peter T Meinke; William H Parsons; Keith A Wafford; Gregory J Kaczorowski
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.
Biochemistry 2004;43(30):9866-76.
2003: Shouwu Miao; Jianming Bao; Maria L Garcia; Joung L Goulet; Xingfang J Hong; Gregory J Kaczorowski; Frank Kayser; Gloria C Koo; Andrew Kotliar; william Schmalhofer; Kashmira Shah; Peter J Sinclair; Robert S Slaughter; Martin S Springer; Mary Jo Staruch; Nancy N Tsou; Frederick Wong; William H Parsons; Kathleen M Rupprecht
Benzamide derivatives as blockers of Kv1.3 ion channel.
Bioorganic & medicinal chemistry letters 2003;13(6):1161-4.
2002: william Schmalhofer; Jianming Bao; Owen B McManus; Brian Green; Mary Matyskiela; Denise Wunderler; Randal M Bugianesi; John P Felix; Markus Hanner; Ana-Rosa Linde-Arias; Cristiano G Ponte; Lucia Velasco; Gloria C Koo; Mary Jo Staruch; Shouwu Miao; William H Parsons; Kathleen M Rupprecht; Robert S Slaughter; Gregory J Kaczorowski; Maria L Garcia
Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties.
Biochemistry 2002;41(24):7781-94.
2002: Jianming Bao; Robert K Baker; George A Doss; Frank Kayser; Andrew Kotliar; Shouwu Miao; William H Parsons; Kathleen M Rupprecht
Novel fragmentation reaction of correolide.
Organic letters 2002;4(11):1871-3.
2002: Suzanne Mandala; Richard Hajdu; James Bergstrom; Elizabeth J Quackenbush; Jenny Xie; James A Milligan; Rosemary Thornton; Gan-Ju Shei; Deborah Card; Carol Ann Keohane; Mark J Rosenbach; Jeffrey Hale; Christopher L Lynch; Kathleen M Rupprecht; William H Parsons; Hugh Rosen
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Science (New York, N.Y.) 2002;296(5566):346-9.
1999: Gloria C Koo; JT Blake; Kashmira Shah; Mary Jo Staruch; Francis J Dumont; Denise Wunderler; Manuel Sanchez; Owen B McManus; A Sirotina-Meisher; P Fischer; R C Boltz; Michael A Goetz; R Baker; Jianming Bao; Frank Kayser; Kathleen M Rupprecht; William H Parsons; X C Tong; I E Ita; James V Pivnichny; S Vincent; P Cunningham; Donald F Hora; William P Feeney; Gregory J Kaczorowski
Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels.
Cellular immunology 1999;197(2):99-107.
1999: siegmund wanner; Hartmut Glossmann; Hans-Günther Knaus; R Baker; William H Parsons; Kathleen M Rupprecht; Richard Brochu; charles cohen; william Schmalhofer; McHardy Smith; Vivien A Warren; Maria L Garcia; Gregory J Kaczorowski
WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels.
Biochemistry 1999;38(34):11137-46.
1999: Joseph W Becker; Jennifer Rotonda; JG Cryan; M Martin; William H Parsons; Peter J Sinclair; GJ Wiederrecht; Frederick Wong
32-Indolyl ether derivatives of ascomycin: three-dimensional structures of complexes with FK506-binding protein.
Journal of medicinal chemistry 1999;42(15):2798-804.
1999: H M Armstrong; Frederick Wong; M A Holmes; Peter J Sinclair; Mark T Goulet; Francis J Dumont; Mary Jo Staruch; Sam L Koprak; Laurence B Peterson; R Rosa; MB Wilusz; GJ Wiederrecht; JG Cryan; Matthew J Wyvratt; William H Parsons
Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity.
Bioorganic & medicinal chemistry letters 1999;9(14):2089-94.
1999: Mark T Goulet; Peter J Sinclair; Frederick Wong; Mary Jo Staruch; Francis J Dumont; JG Cryan; GJ Wiederrecht; Matthew J Wyvratt; William H Parsons
C32-O-phenalkyl ether derivatives of the immunosuppressant ascomycin: a tether length study.
Bioorganic & medicinal chemistry letters 1999;9(14):2085-8.
1999: John P Felix; Randal M Bugianesi; william Schmalhofer; Robert P Borris; Michael A Goetz; OD Hensens; J M Bao; Frank Kayser; William H Parsons; Kathleen M Rupprecht; Maria L Garcia; Gregory J Kaczorowski; Robert S Slaughter
Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3.
Biochemistry 1999;38(16):4922-30.
1998: Mark T Goulet; S R McAlpine; Mary Jo Staruch; Sam L Koprak; Francis J Dumont; JG Cryan; GJ Wiederrecht; R Rosa; MB Wilusz; Laurence B Peterson; Matthew J Wyvratt; William H Parsons
C32-O-imidazol-2-yl-methyl ether derivatives of the immunosuppressant ascomycin with improved therapeutic potential.
Bioorganic & medicinal chemistry letters 1998;8(16):2253-8.
1998: F J Dumont; Sam L Koprak; Mary Jo Staruch; A Talento; Gloria C Koo; C DaSilva; Peter J Sinclair; Frederick Wong; J Woods; J Barker; James V Pivnichny; I Singer; NH Sigal; A R Williamson; William H Parsons; Matthew J Wyvratt
A tacrolimus-related immunosuppressant with reduced toxicity.
Transplantation 1998;65(1):18-26.
1998: Laurence B Peterson; JG Cryan; R Rosa; M M Martin; MB Wilusz; Peter J Sinclair; Frederick Wong; J N Parsons; S J O'Keefe; William H Parsons; Matthew J Wyvratt; NH Sigal; A R Williamson; GJ Wiederrecht
A tacrolimus-related immunosuppressant with biochemical properties distinct from those of tacrolimus.
Transplantation 1998;65(1):10-8.
1996: Gloria C Koo; Y Luk; A Talento; J Wu; A Sirotina; P A Fischer; J T Blake; M P Nguyen; William H Parsons; M Poe
Association of serine protease with the rise of intracellular calcium in cytotoxic T lymphocytes.
Cellular immunology 1996;174(2):107-15.
1994: M M Ponpipom; N N Girotra; R L Bugianesi; C D Roberts; G D Berger; R M Burk; R W Marquis; William H Parsons; Ken Bartizal; J D Bergstom
Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Journal of medicinal chemistry 1994;37(23):4031-51.
1994: T Biftu; J J Acton; G D Berger; James Bergstrom; C Dufresne; M M Kurtz; R W Marquis; William H Parsons; D R Rew; K E Wilson
Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.
Journal of medicinal chemistry 1994;37(3):421-4.
1993: William H Parsons; Nolan Sigal; Matthew J Wyvratt
FK-506--a novel immunosuppressant.
Annals of the New York Academy of Sciences 1993;685():22-36.
1992: N N Girotra; T Biftu; M M Ponpipom; J J Acton; A W Alberts; T N Bach; R G Ball; R L Bugianesi; William H Parsons; J C Chabala
Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.
Journal of medicinal chemistry 1992;35(19):3474-82.