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Bryce Paschal

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Chemicals & Drugs

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Chelsi J Snow; Ashraf Dar; Anindya Dutta; Ralph H Kehlenbach; Bryce M Paschal
Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.
Daniel Gioeli; Bryce M Paschal
Post-translational modification of the androgen receptor.
Joshua B Kelley; Michael J Matunis; Li Ni; Mandovi Chatterjee; Caelin Cubeñas-Potts; Sutirtha Datta; Chelsi J Snow; Adam Spencer; Chun-Song Yang; Bryce M Paschal
The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.

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All Publications

2013: Chelsi J Snow; Ashraf Dar; Anindya Dutta; Ralph H Kehlenbach; Bryce M Paschal
Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport.
The Journal of cell biology 2013;201(4):541-57.
2012: Daniel Gioeli; Bryce M Paschal
Post-translational modification of the androgen receptor.
Molecular and cellular endocrinology 2012;352(1-2):70-8.
2011: Joshua B Kelley; Michael J Matunis; Li Ni; Mandovi Chatterjee; Caelin Cubeñas-Potts; Sutirtha Datta; Chelsi J Snow; Adam Spencer; Chun-Song Yang; Bryce M Paschal
The defective nuclear lamina in Hutchinson-gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9.
Molecular and cellular biology 2011;31(16):3378-95.
2010: Stephen R Braddock; Holly H Ardinger; Chun-Song Yang; Bryce M Paschal; Bryan D Hall
Petty syndrome and Fontaine-Farriaux syndrome: Delineation of a single syndrome.
American journal of medical genetics. Part A 2010;152A(7):1718-23.
2010: Li Ni; Chun-Song Yang; Daniel Gioeli; Henry Frierson; David O Toft; Bryce M Paschal
FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells.
Molecular and cellular biology 2010;30(5):1243-53.
2010: Joshua B Kelley; Ashley M Talley; Adam Spencer; Daniel Gioeli; Bryce M Paschal
Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors.
BMC cell biology 2010;11():63.
2009: Mary T Galgano; Mark Conaway; Adam M Spencer; Bryce M Paschal; Henry F Frierson
PRK1 distribution in normal tissues and carcinomas: overexpression and activation in ovarian serous carcinoma.
Human pathology 2009;40(10):1434-40.
2009: Shaoyong Chen; Cristina T Kesler; Bryce M Paschal; Steven P Balk
Androgen receptor phosphorylation and activity are regulated by an association with protein phosphatase 1.
The Journal of biological chemistry 2009;284(38):25576-84.
2009: Sanna Kaikkonen; Tiina Jääskeläinen; Ulla Karvonen; Miia M Rytinki; Harri Makkonen; Daniel Gioeli; Bryce M Paschal; Jorma J Palvimo
SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells.
Molecular endocrinology (Baltimore, Md.) 2009;23(3):292-307.
2008: Leonard C Shank; Joshua B Kelley; Daniel Gioeli; Chun-Song Yang; Adam Spencer; Lizabeth A Allison; Bryce M Paschal
Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro.
The Journal of biological chemistry 2008;283(16):10568-80.
2007: Joshua B Kelley; Bryce M Paschal
Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP.
Molecular biology of the cell 2007;18(11):4365-76.
2007: Cristina T Kesler; Daniel Gioeli; Mark Conaway; Michael J Weber; Bryce M Paschal
Subcellular localization modulates activation function 1 domain phosphorylation in the androgen receptor.
Molecular endocrinology (Baltimore, Md.) 2007;21(9):2071-84.
2007: Kai Sun; Vedrana Montana; Karthikeyani Chellappa; Yann Brelivet; Dino Moras; Yutaka Maeda; Vladimir Parpura; Bryce M Paschal; Frances M Sladek
Phosphorylation of a conserved serine in the deoxyribonucleic acid binding domain of nuclear receptors alters intracellular localization.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1297-311.
2007: Chun-Song Yang; Hong-Wu Xin; Joshua B Kelley; Adam Spencer; David L Brautigan; Bryce M Paschal
Ligand binding to the androgen receptor induces conformational changes that regulate phosphatase interactions.
Molecular and cellular biology 2007;27(9):3390-404.
2006: Lucy F Pemberton; Bryce M Paschal
Scientists share nuclear secrets at Jekyll Island.
Traffic (Copenhagen, Denmark) 2006;7(6):751-60.
2006: Daniel Gioeli; Ben E Black; Vicki Gordon; Adam Spencer; Cristina T Kesler; Scott T. Eblen; Bryce M Paschal; Michael J Weber
Stress kinase signaling regulates androgen receptor phosphorylation, transcription, and localization.
Molecular endocrinology (Baltimore, Md.) 2006;20(3):503-15.
2006: Lyne Lévesque; Yeou-cherng Bor; Leah H Matzat; Li Jin; Stephen Berberoglu; David Rekosh; Marie-Louise Hammarskjöld; Bryce M Paschal
Mutations in tap uncouple RNA export activity from translocation through the nuclear pore complex.
Molecular biology of the cell 2006;17(2):931-43.
2005: Nima Afshar; Ben E Black; Bryce M Paschal
Retrotranslocation of the chaperone calreticulin from the endoplasmic reticulum lumen to the cytosol.
Molecular and cellular biology 2005;25(20):8844-53.
2005: Lucy F Pemberton; Bryce M Paschal
Mechanisms of receptor-mediated nuclear import and nuclear export.
Traffic (Copenhagen, Denmark) 2005;6(3):187-98.
2005: Chun-Song Yang; Michael J Vitto; Scott A Busby; Benjamin A Garcia; Cristina T Kesler; Daniel Gioeli; Jeffrey Shabanowitz; Donald F Hunt; Mary Kathleen Rundell; David L Brautigan; Bryce M Paschal
Simian virus 40 small t antigen mediates conformation-dependent transfer of protein phosphatase 2A onto the androgen receptor.
Molecular and cellular biology 2005;25(4):1298-308.
2005: Leonard C Shank; Bryce M Paschal
Nuclear transport of steroid hormone receptors.
Critical reviews in eukaryotic gene expression 2005;15(1):49-73.
2004: Ben E Black; Bryce M Paschal
Intranuclear organization and function of the androgen receptor.
Trends in endocrinology and metabolism: TEM 2004;15(9):411-7.
2004: Nahum Meller; Mohammad Irani-Tehrani; Boris I Ratnikov; Bryce M Paschal; Martin A Schwartz
The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain.
The Journal of biological chemistry 2004;279(36):37470-6.
2004: Ben E Black; Michael J Vitto; Daniel Gioeli; Adam Spencer; Nima Afshar; Mark Conaway; Michael J Weber; Bryce M Paschal
Transient, ligand-dependent arrest of the androgen receptor in subnuclear foci alters phosphorylation and coactivator interactions.
Molecular endocrinology (Baltimore, Md.) 2004;18(4):834-50.
2002: Bryce M Paschal
Translocation through the nuclear pore complex.
Trends in biochemical sciences 2002;27(12):593-6.
2002: James M Holaska; Ben E Black; Fraydoon Rastinejad; Bryce M Paschal
Ca2+-dependent nuclear export mediated by calreticulin.
Molecular and cellular biology 2002;22(17):6286-97.
2002: Amy M Brownawell; James M Holaska; Ian G Macara; Bryce M Paschal
The use of permeabilized cell systems to study nuclear transport.
Methods in molecular biology (Clifton, N.J.) 2002;189():209-29.
2002: Susanne M Steggerda; Bryce M Paschal
Regulation of nuclear import and export by the GTPase Ran.
International review of cytology 2002;217():41-91.
2001: Lyne Lévesque; Brian W Guzik; Tinglu Guan; J Coyle; Ben E Black; David Rekosh; Marie-Louise Hammarskjöld; Bryce M Paschal
RNA export mediated by tap involves NXT1-dependent interactions with the nuclear pore complex.
The Journal of biological chemistry 2001;276(48):44953-62.
2001: Ben E Black; James M Holaska; Fraydoon Rastinejad; Bryce M Paschal
DNA binding domains in diverse nuclear receptors function as nuclear export signals.
Current biology : CB 2001;11(22):1749-58.
2001: Susanne M Steggerda; Bryce M Paschal
Identification of a conserved loop in Mog1 that releases GTP from Ran.
Traffic (Copenhagen, Denmark) 2001;2(11):804-11.
2001: Mark E Lindsay; James M Holaska; K Welch; Bryce M Paschal; Ian G Macara
Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export.
The Journal of cell biology 2001;153(7):1391-402.
2001: Brian W Guzik; L Levesque; S Prasad; Yeou-cherng Bor; Ben E Black; Bryce M Paschal; David Rekosh; Marie-Louise Hammarskjöld
NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells.
Molecular and cellular biology 2001;21(7):2545-54.
2001: Ben E Black; James M Holaska; Lyne Lévesque; Batool Ossareh-Nazari; Carole Gwizdek; Catherine Dargemont; Bryce M Paschal
NXT1 is necessary for the terminal step of Crm1-mediated nuclear export.
The Journal of cell biology 2001;152(1):141-55.
2001: James M Holaska; Ben E Black; Dona C Love; John Hanover; John Leszyk; Bryce M Paschal
Calreticulin Is a receptor for nuclear export.
The Journal of cell biology 2001;152(1):127-40.
2000: Susanne M Steggerda; Bryce M Paschal
The mammalian Mog1 protein is a guanine nucleotide release factor for Ran.
The Journal of biological chemistry 2000;275(30):23175-80.
2000: Batool Ossareh-Nazari; Christèle Maison; Ben E Black; Lyne Lévesque; Bryce M Paschal; Catherine Dargemont
RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro.
Molecular and cellular biology 2000;20(13):4562-71.
2000: Susanne M Steggerda; Ben E Black; Bryce M Paschal
Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran.
Molecular biology of the cell 2000;11(2):703-19.
1999: Ben E Black; Lyne Lévesque; James M Holaska; TC Wood; Bryce M Paschal
Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.
Molecular and cellular biology 1999;19(12):8616-24.
1999: S Hübner; HM Smith; Wei Hu; Chee-Kai Chan; H P Rihs; Bryce M Paschal; Natasha V Raikhel; David A Jans
Plant importin alpha binds nuclear localization sequences with high affinity and can mediate nuclear import independent of importin beta.
The Journal of biological chemistry 1999;274(32):22610-7.
1999: B Liao; Bryce M Paschal; Kate Luby-Phelps
Mechanism of Ca2+-dependent nuclear accumulation of calmodulin.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6217-22.
1998: James M Holaska; Bryce M Paschal
A cytosolic activity distinct from crm1 mediates nuclear export of protein kinase inhibitor in permeabilized cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(25):14739-44.
1997: W D Clarkson; Anita H Corbett; Bryce M Paschal; Helen M Kent; Airlie J McCoy; Larry Gerace; P A Silver; Murray Stewart
Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran.
Journal of molecular biology 1997;272(5):716-30.
1997: Bryce M Paschal; C Fritze; Tinglu Guan; Larry Gerace
High levels of the GTPase Ran/TC4 relieve the requirement for nuclear protein transport factor 2.
The Journal of biological chemistry 1997;272(34):21534-9.
1996: J F Dillman; L P Dabney; Sher Karki; Bryce M Paschal; Erika L F Holzbaur; K Kevin Pfister
Functional analysis of dynactin and cytoplasmic dynein in slow axonal transport.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(21):6742-52.
1996: Kevin T Vaughan; A Mikami; Bryce M Paschal; Erika L F Holzbaur; S M Hughes; CJ Echeverri; K J Moore; D J Gilbert; N G Copeland; N A Jenkins; Richard B Vallee
Multiple mouse chromosomal loci for dynein-based motility.
Genomics 1996;36(1):29-38.
1996: Bryce M Paschal; C Delphin; Larry Gerace
Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7679-83.
1996: CJ Echeverri; Bryce M Paschal; Kevin T Vaughan; Richard B Vallee
Molecular characterization of the 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis.
The Journal of cell biology 1996;132(4):617-33.
1995: Tinglu Guan; S Müller; G Klier; N Panté; J M Blevitt; M Haner; Bryce M Paschal; U Aebi; Larry Gerace
Structural analysis of the p62 complex, an assembly of O-linked glycoproteins that localizes near the central gated channel of the nuclear pore complex.
Molecular biology of the cell 1995;6(11):1591-603.
1995: Bryce M Paschal; Larry Gerace
Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.
The Journal of cell biology 1995;129(4):925-37.
1995: F Melchior; Tinglu Guan; Bryce M Paschal; Larry Gerace
Biochemical and structural analysis of nuclear protein import.
Cold Spring Harbor symposia on quantitative biology 1995;60():707-16.
1994: S W Clark; O Staub; I B Clark; Erika L F Holzbaur; Bryce M Paschal; Richard B Vallee; David I Meyer
Beta-centractin: characterization and distribution of a new member of the centractin family of actin-related proteins.
Molecular biology of the cell 1994;5(12):1301-10.
1993: F Melchior; Bryce M Paschal; J Evans; Larry Gerace
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor.
The Journal of cell biology 1993;123(6 Pt 2):1649-59.
1993: Bryce M Paschal; Erika L F Holzbaur; K Kevin Pfister; S Clark; David I Meyer; Richard B Vallee
Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin.
The Journal of biological chemistry 1993;268(20):15318-23.
1993: A Mikami; Bryce M Paschal; M Mazumdar; Richard B Vallee
Molecular cloning of the retrograde transport motor cytoplasmic dynein (MAP 1C).
Neuron 1993;10(5):787-96.
1993: Bryce M Paschal; Richard B Vallee
Microtubule and axoneme gliding assays for force production by microtubule motor proteins.
Methods in cell biology 1993;39():65-74.
1992: Erika L F Holzbaur; J A Hammarback; Bryce M Paschal; N G Kravit; K Kevin Pfister; Richard B Vallee
Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued.
Nature 1992;360(6405):695.
1992: Bryce M Paschal; A Mikami; K Kevin Pfister; Richard B Vallee
Homology of the 74-kD cytoplasmic dynein subunit with a flagellar dynein polypeptide suggests an intracellular targeting function.
The Journal of cell biology 1992;118(5):1133-43.
1991: Erika L F Holzbaur; J A Hammarback; Bryce M Paschal; N G Kravit; K Kevin Pfister; Richard B Vallee
Homology of a 150K cytoplasmic dynein-associated polypeptide with the Drosophila gene Glued.
Nature 1991;351(6327):579-83.
1991: Bryce M Paschal; H S Shpetner; Richard B Vallee
Purification of brain cytoplasmic dynein and characterization of its in vitro properties.
Methods in enzymology 1991;196():181-91.
1990: Richard B Vallee; H S Shpetner; Bryce M Paschal
Potential roles of microtubule-associated motor molecules in cell division.
Annals of the New York Academy of Sciences 1990;582():99-107.
1989: Bryce M Paschal; Bob Obar; Richard B Vallee
Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin.
Nature 1989;342(6249):569-72.
1989: Richard B Vallee; H S Shpetner; Bryce M Paschal
The role of dynein in retrograde axonal transport.
Trends in neurosciences 1989;12(2):66-70.
1989: Richard B Vallee; H S Shpetner; Bryce M Paschal
The role of dynein and other microtubule-activated ATPases in mitosis.
Progress in clinical and biological research 1989;318():205-15.
1988: H S Shpetner; Bryce M Paschal; Richard B Vallee
Characterization of the microtubule-activated ATPase of brain cytoplasmic dynein (MAP 1C).
The Journal of cell biology 1988;107(3):1001-9.
1988: Richard B Vallee; J S Wall; Bryce M Paschal; H S Shpetner
Microtubule-associated protein 1C from brain is a two-headed cytosolic dynein.
Nature 1988;332(6164):561-3.
1987: Bryce M Paschal; Stephen M King; A G Moss; C A Collins; Richard B Vallee; George B Witman
Isolated flagellar outer arm dynein translocates brain microtubules in vitro.
Nature 1987;330(6149):672-4.
1987: Bryce M Paschal; Richard B Vallee
Retrograde transport by the microtubule-associated protein MAP 1C.
Nature 1987;330(6144):181-3.
1987: Bryce M Paschal; H S Shpetner; Richard B Vallee
MAP 1C is a microtubule-activated ATPase which translocates microtubules in vitro and has dynein-like properties.
The Journal of cell biology 1987;105(3):1273-82.
1987: L Molony; D McCaslin; J Abernethy; Bryce M Paschal; Keith Burridge
Properties of talin from chicken gizzard smooth muscle.
The Journal of biological chemistry 1987;262(16):7790-5.
1986: Robert Sealock; Bryce M Paschal; M Beckerle; Keith Burridge
Talin is a post-synaptic component of the rat neuromuscular junction.
Experimental cell research 1986;163(1):143-50.