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Wulf Paschen
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19
Hossmann, Konstantin-Alexander
17
Doutheil, J
14
Mies, Günter
11
Gissel, C
11
Althausen, Sonja
11
Mengesdorf, Thorsten
5
Dux, E
4
Ernestus, Ralf-Ingo
4
Aufenberg, Christoph
4
Linden, T
4
Sheng, Huaxin
4
Warner, David
3
Oláh, Laszlo
3
Hotop, Svenja
3
Klug, Norfrid
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All Publications
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2009: Sheng Huaxin; Yang Wei; Fukuda Shiro; Tse Hubert M; Paschen Wulf; Johnson Kwame; Batinic-Haberle Ines; Crapo James D; Pearlstein Robert D; Piganelli Jon; Warner David S
Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat.
Free radical biology & medicine 2009;47(7):917-23.
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2009: Yang Wei; Paschen Wulf
The endoplasmic reticulum and neurological diseases.
Experimental neurology 2009;219(2):376-81.
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2009: Yang Wei; Ma Qing; Mackensen G Burkhard; Paschen Wulf
Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(5):886-90.
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2009: Yang Wei; Paschen Wulf
Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression.
Biochemical and biophysical research communications 2009;382(1):215-8.
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2008: Yang Wei; Sheng Huaxin; Homi H Mayumi; Warner David S; Paschen Wulf
Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention?
Journal of neurochemistry 2008;106(3):989-99.
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2008: Yang Wei; Sheng Huaxin; Warner David S; Paschen Wulf
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(5):892-6.
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2008: Yang Wei; Sheng Huaxin; Warner David S; Paschen Wulf
Transient global cerebral ischemia induces a massive increase in protein sumoylation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):269-79.
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2008: Yang Wei; Paschen Wulf
Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter.
Biochemical and biophysical research communications 2008;365(3):521-7.
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2007: Paschen Wulf; Proud Christopher G; Mies Günter
Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance.
Current pharmaceutical design 2007;13(18):1887-902.
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2005: Paschen Wulf; Mengesdorf Thorsten
Cellular abnormalities linked to endoplasmic reticulum dysfunction in cerebrovascular disease--therapeutic potential.
Pharmacology & therapeutics 2005;108(3):362-75.
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2005: Aufenberg Christoph; Wenkel Simone; Mautes Angelika; Paschen Wulf
Spinal cord trauma activates processing of xbp1 mRNA indicative of endoplasmic reticulum dysfunction.
Journal of neurotrauma 2005;22(9):1018-24.
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2005: Paschen Wulf; Mengesdorf Thorsten
Endoplasmic reticulum stress response and neurodegeneration.
Cell calcium 2005;38(3-4):409-15.
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2004: Schneeloch Edda; Wenkel Simone; Mies Günter; Paschen Wulf
Spreading depression activates unfolded protein response.
Neuroscience letters 2004;368(1):37-40.
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2004: Paschen Wulf; Hayashi Takeshi; Saito Atsushi; Chan Pak H
GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post-ischemic recovery of protein synthesis in ischemia-resistant cells.
Journal of neurochemistry 2004;90(3):694-701.
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2004: Paschen Wulf
Endoplasmic reticulum dysfunction in brain pathology: critical role of protein synthesis.
Current neurovascular research 2004;1(2):173-81.
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2004: Paschen Wulf; Yatsiv Ido; Shoham Shai; Shohami Esther
Brain trauma induces X-box protein 1 processing indicative of activation of the endoplasmic reticulum unfolded protein response.
Journal of neurochemistry 2004;88(4):983-92.
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2003: Paschen Wulf
Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain.
Cell calcium 2003;34(4-5):365-83.
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2003: Paschen Wulf
Mechanisms of neuronal cell death: diverse roles of calcium in the various subcellular compartments.
Cell calcium 2003;34(4-5):305-10.
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2003: Paschen Wulf; Mengesdorf Thorsten
Conditions associated with ER dysfunction activate homer 1a expression.
Journal of neurochemistry 2003;86(5):1108-15.
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2003: Paschen Wulf
Shutdown of translation: lethal or protective? Unfolded protein response versus apoptosis.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(7):773-9.
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2003: Paschen Wulf; Aufenberg Christoph; Hotop Svenja; Mengesdorf Thorsten
Transient cerebral ischemia activates processing of xbp1 messenger RNA indicative of endoplasmic reticulum stress.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(4):449-61.
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2003: Paschen Wulf; Hotop Svenja; Aufenberg Christoph
Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress.
Cell calcium 2003;33(2):83-9.
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2002: Mengesdorf Thorsten; Jensen Poul H; Mies Gunter; Aufenberg Christoph; Paschen Wulf
Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15042-7.
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2002: Mengesdorf Thorsten; Proud Christopher G; Mies Günter; Paschen Wulf
Mechanisms underlying suppression of protein synthesis induced by transient focal cerebral ischemia in mouse brain.
Experimental neurology 2002;177(2):538-46.
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2002: Mengesdorf Thorsten; Althausen Sonja; Paschen Wulf
Genes associated with pro-apoptotic and protective mechanisms are affected differently on exposure of neuronal cell cultures to arsenite. No indication for endoplasmic reticulum stress despite activation of grp78 and gadd153 expression.
Brain research. Molecular brain research 2002;104(2):227-39.
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2002: Mengesdorf Thorsten; Althausen Sonja; Mies Günter; Oláh Laszlo; Paschen Wulf
Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain.
Neurochemical research 2002;27(6):477-84.
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2001: Paschen W; Frandsen A
Endoplasmic reticulum dysfunction--a common denominator for cell injury in acute and degenerative diseases of the brain?
Journal of neurochemistry 2001;79(4):719-25.
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2001: Althausen S; Mengesdorf T; Mies G; Oláh L; Nairn A C; Proud C G; Paschen W
Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice.
Journal of neurochemistry 2001;78(4):779-87.
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2001: Mengesdorf T; Althausen S; Oberndorfer I; Paschen W
Response of neurons to an irreversible inhibition of endoplasmic reticulum Ca(2+)-ATPase: relationship between global protein synthesis and expression and translation of individual genes.
The Biochemical journal 2001;356(Pt 3):805-12.
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2001: Paschen W; Mengesdorf T; Althausen S; Hotop S
Peroxidative stress selectively down-regulates the neuronal stress response activated under conditions of endoplasmic reticulum dysfunction.
Journal of neurochemistry 2001;76(6):1916-24.
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2001: Paschen W
Dependence of vital cell function on endoplasmic reticulum calcium levels: implications for the mechanisms underlying neuronal cell injury in different pathological states.
Cell calcium 2001;29(1):1-11.
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2000: Althausen S; Paschen W
Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures.
Brain research. Molecular brain research 2000;84(1-2):32-40.
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2000: Paschen W; Oláh L; Mies G
Effect of transient focal ischemia of mouse brain on energy state and NAD levels: no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism.
Journal of neurochemistry 2000;75(4):1675-80.
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2000: Doutheil J; Althausen S; Treiman M; Paschen W
Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism.
Cell calcium 2000;27(2):107-15.
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1999: Doutheil J; Paschen W
Effect of 3,4,5-trimethoxybenzoic acid 8-diethylamino-octyl ester (TMB-8) on neuronal calcium homeostasis, protein synthesis, and energy metabolism.
Pharmacology & toxicology 1999;85(2):85-91.
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1999: Doutheil J; Treiman M; Oschlies U; Paschen W
Recovery of neuronal protein synthesis after irreversible inhibition of the endoplasmic reticulum calcium pump.
Cell calcium 1999;25(6):419-28.
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1999: Paschen W; Mies G
Effect of induced tolerance on biochemical disturbances in hippocampal slices from the gerbil during and after oxygen/glucose deprivation.
Neuroreport 1999;10(7):1417-21.
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1999: Paschen W; Althausen S; Doutheil J
Ischemia-induced changes in 2'-5'-oligoadenylate synthethase mRNA levels in rat brain: comparison with changes produced by perturbations of endoplasmic reticulum calcium homeostasis in neuronal cell cultures.
Neuroscience letters 1999;263(2-3):109-12.
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1999: Paschen W; Doutheil J
Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury?
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(1):1-18.
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1999: Doutheil J; Althausen S; Gissel C; Paschen W
Activation of MYD116 (gadd34) expression following transient forebrain ischemia of rat: implications for a role of disturbances of endoplasmic reticulum calcium homeostasis.
Brain research. Molecular brain research 1999;63(2):225-32.
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1999: Paschen W; Doutheil J
Disturbance of endoplasmic reticulum functions: a key mechanism underlying cell damage?
Acta neurochirurgica. Supplement 1999;73():1-5.
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1998: Paschen W; Gissel C; Althausen S; Doutheil J
Changes in interferon-regulatory factor-1 mRNA levels after transient ischemia in rat brain.
Neuroreport 1998;9(14):3147-51.
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1998: Paschen W; Gissel C; Linden T; Althausen S; Doutheil J
Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction.
Brain research. Molecular brain research 1998;60(1):115-22.
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1998: Linden T; Doutheil J; Paschen W
Role of calcium in the activation of erp72 and heme oxygenase-1 expression on depletion of endoplasmic reticulum calcium stores in rat neuronal cell culture.
Neuroscience letters 1998;247(2-3):103-6.
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1998: Paschen W; Linden T; Doutheil J
Effects of transient cerebral ischemia on hsp40 mRNA levels in rat brain.
Brain research. Molecular brain research 1998;55(2):341-4.
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1998: Paschen W; Gissel C; Linden T; Doutheil J
Erp72 expression activated by transient cerebral ischemia or disturbance of neuronal endoplasmic reticulum calcium stores.
Metabolic brain disease 1998;13(1):55-68.
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1998: Berger R; Jensen A; Hossmann K A; Paschen W
Effect of mild hypothermia during and after transient in vitro ischemia on metabolic disturbances in hippocampal slices at different stages of development.
Brain research. Developmental brain research 1998;105(1):67-77.
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1997: Gissel C; Doutheil J; Paschen W
Temporal analysis of changes in neuronal c-fos mRNA levels induced by depletion of endoplasmic reticulum calcium stores: effect of clamping cytoplasmic calcium activity at resting levels.
Journal of neurochemistry 1997;69(6):2538-45.
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1997: Doutheil J; Gissel C; Oschlies U; Hossmann K A; Paschen W
Relation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggregation and protein synthesis: implications for stress-induced suppression of protein synthesis.
Brain research 1997;775(1-2):43-51.
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1997: Mies G; Djuricic B; Paschen W; Hossmann K A
Quantitative measurement of cerebral protein synthesis in vivo: theory and methodological considerations.
Journal of neuroscience methods 1997;76(1):35-44.
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1997: Gissel C; Doutheil J; Paschen W
Activation of heme oxygenase-1 expression by disturbance of endoplasmic reticulum calcium homeostasis in rat neuronal cell culture.
Neuroscience letters 1997;231(2):75-8.
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1997: Berger R; Jensen A; Hossmann K A; Paschen W
No effect of glutamate on metabolic disturbances in hippocampal slices of mature fetal guinea pigs after transient in vitro ischemia.
Brain research. Developmental brain research 1997;101(1-2):49-56.
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1997: Paschen W; Schmitt J; Gissel C; Dux E
Developmental changes of RNA editing of glutamate receptor subunits GluR5 and GluR6: in vivo versus in vitro.
Brain research. Developmental brain research 1997;98(2):271-80.
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1996: Paschen W; Doutheil J; Uto A; Gissel C
Changes in endoplasmic reticulum Ca(2-)-ATPase mRNA levels in transient cerebral ischemia of rat: a quantitative polymerase chain reaction study.
Neuroscience letters 1996;217(1):41-4.
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1996: Paschen W; Doutheil J; Gissel C; Treiman M
Depletion of neuronal endoplasmic reticulum calcium stores by thapsigargin: effect on protein synthesis.
Journal of neurochemistry 1996;67(4):1735-43.
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1996: Kusumoto M; Dux E; Paschen W; Hossmann K A
Susceptibility of hippocampal and cortical neurons to argon-mediated in vitro ischemia.
Journal of neurochemistry 1996;67(4):1613-21.
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1996: Ernestus R I; Röhn G; Schröder R; Els T; Lee J Y; Klug N; Paschen W
Polyamine metabolism in gliomas.
Journal of neuro-oncology 1996;29(2):167-74.
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1996: Paschen W; Schmitt J; Uto A
RNA editing of glutamate receptor subunits GluR2, GluR5 and GluR6 in transient cerebral ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(4):548-56.
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1996: Berger R; Djuricic B; Jensen A; Hossmann K A; Paschen W
Ontogenetic differences in energy metabolism and inhibition of protein synthesis in hippocampal slices during in vitro ischemia and 24 h of recovery.
Brain research. Developmental brain research 1996;91(2):281-91.
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1996: Schmitt J; Dux E; Gissel C; Paschen W
Regional analysis of developmental changes in the extent of GluR6 mRNA editing in rat brain.
Brain research. Developmental brain research 1996;91(1):153-7.
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1996: Paschen W
Glutamate excitotoxicity in transient global cerebral ischemia.
Acta neurobiologiae experimentalis 1996;56(1):313-22.
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1995: Paschen W
Comparison of biochemical disturbances in hippocampal slices of gerbil and rat during and after in vitro ischemia.
Neuroscience letters 1995;199(1):41-4.
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1995: Paschen W; Djuricic B
Comparison of in vitro ischemia-induced disturbances in energy metabolism and protein synthesis in the hippocampus of rats and gerbils.
Journal of neurochemistry 1995;65(4):1692-7.
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1995: Paschen W; Schmitt J; Dux E; Djuricic B
Temporal analysis of the upregulation of GluR5 mRNA editing with age: regional evaluation.
Brain research. Developmental brain research 1995;86(1-2):359-63.
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1995: Djuricic B; Röhn G; Paschen W; Hossmann K A
Calcium activity and post-ischemic suppression of protein synthesis.
Experientia 1995;51(3):245-8.
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1995: Paschen W; Djuricic B
Regional differences in the extent of RNA editing of the glutamate receptor subunits GluR2 and GluR6 in rat brain.
Journal of neuroscience methods 1995;56(1):21-9.
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1995: Berger R; Djuricic B; Jensen A; Paschen W
[Cerebral ischemia: ontogenetic differences in energy metabolism and protein biosynthesis]
Gynäkologisch-geburtshilfliche Rundschau 1995;35 Suppl 1():19-24.
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1994: Djuricic B; Berger R; Paschen W
Protein synthesis and energy metabolism in hippocampal slices during extended (24 hours) recovery following different periods of ischemia.
Metabolic brain disease 1994;9(4):377-89.
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1994: Paschen W; Uto A; Djuricic B; Schmitt J
Hemeoxygenase expression after reversible ischemia of rat brain.
Neuroscience letters 1994;180(1):5-8.
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1994: Djuricic B; Röhn G; Paschen W; Hossmann K A
Protein synthesis in the hippocampal slice: transient inhibition by glutamate and lasting inhibition by ischemia.
Metabolic brain disease 1994;9(3):235-47.
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1994: Paschen W; Dux E; Djuricic B
Developmental changes in the extent of RNA editing of glutamate receptor subunit GluR5 in rat brain.
Neuroscience letters 1994;174(1):109-12.
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1994: Paschen W; Djuricic B
Extent of RNA editing of glutamate receptor subunit GluR5 in different brain regions of the rat.
Cellular and molecular neurobiology 1994;14(3):259-70.
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1993: Ernestus R I; Röhn G; Hossmann K A; Paschen W
Polyamine metabolism in experimental brain tumors of rat.
Journal of neurochemistry 1993;60(2):417-22.
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1993: Paschen W; Cleef M; Röhn G; Müller M; Pajunen A E
Ischemia-induced disturbances of polyamine synthesis.
Progress in brain research 1993;96():147-60.
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1992: Paschen W; Mies G; Hossmann K A
Threshold relationship between cerebral blood flow, glucose utilization, and energy metabolites during development of stroke in gerbils.
Experimental neurology 1992;117(3):325-33.
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1992: Röhn G; Schlenker M; Paschen W
Activity of ornithine decarboxylase and S-adenosylmethionine decarboxylase in transient cerebral ischemia: relationship to the duration of vascular occlusion.
Experimental neurology 1992;117(2):210-5.
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1992: Paschen W
Polyamine metabolism in different pathological states of the brain.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1992;16(3):241-71.
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1992: Paschen W; Widmann R; Weber C
Changes in regional polyamine profiles in rat brains after transient cerebral ischemia (single versus repetitive ischemia): evidence for release of polyamines from injured neurons.
Neuroscience letters 1992;135(1):121-4.
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1992: Ernestus R I; Röhn G; Schröder R; Klug N; Hossmann K A; Paschen W
Activity of ornithine decarboxylase (ODC) and polyamine levels as biochemical markers of malignancy in human brain tumors.
Acta histochemica. Supplementband 1992;42():159-64.
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1992: Paschen W
Polyamine metabolism in reversible cerebral ischemia.
Cerebrovascular and brain metabolism reviews 1992;4(1):59-88.
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1992: Röhn G; Ernestus R I; Schröder R; Hossmann K A; Klug N; Paschen W
Transglutaminase activity in human brain tumors.
Acta histochemica. Supplementband 1992;42():155-8.
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1991: Paschen W; Csiba L; Röhn G; Bereczki D
Polyamine metabolism in transient focal ischemia of rat brain.
Brain research 1991;566(1-2):354-7.
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1991: Paschen W; Bengtsson F; Röhn G; Bonnekoh P; Siesjö B; Hossmann K A
Cerebral polyamine metabolism in reversible hypoglycemia of rat: relationship to energy metabolites and calcium.
Journal of neurochemistry 1991;57(1):204-15.
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1991: Müller M; Cleef M; Röhn G; Bonnekoh P; Pajunen A E; Bernstein H G; Paschen W
Ornithine decarboxylase in reversible cerebral ischemia: an immunohistochemical study.
Acta neuropathologica 1991;83(1):39-45.
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1990: Mies G; Paschen W; Hossmann K A
Cerebral blood flow, glucose utilization, regional glucose, and ATP content during the maturation period of delayed ischemic injury in gerbil brain.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1990;10(5):638-45.
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1990: Röhn G; Kocher M; Oschlies U; Hossmann K A; Paschen W
Putrescine content and structural defects in isolated fractions of rat brain after reversible cerebral ischemia.
Experimental neurology 1990;107(3):249-55.
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1990: Paschen W; Hallmayer J; Mies G; Röhn G
Ornithine decarboxylase activity and putrescine levels in reversible cerebral ischemia of Mongolian gerbils: effect of barbiturate.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1990;10(2):236-42.
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1990: Paschen W; Röhn G; Schmidt-Kastner R
Transglutaminase activity in reversible cerebral ischemia in the rat.
Neuroscience letters 1990;110(1-2):232-6.
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1990: Paschen W
Imaging of energy metabolites (ATP, glucose and lactate) in tissue sections: a bioluminescent technique.
Progress in histochemistry and cytochemistry 1990;20(4):1-122.
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1989: Schmidt-Kastner R; Paschen W; Ophoff B G; Hossmann K A
A modified four-vessel occlusion model for inducing incomplete forebrain ischemia in rats.
Stroke; a journal of cerebral circulation 1989;20(7):938-46.
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1988: Paschen W; Röhn G; Hallmayer J; Mies G
Polyamine metabolism in reversible cerebral ischemia of Mongolian gerbils.
Metabolic brain disease 1988;3(4):297-302.
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1988: Hossmann K A; Ophoff B G; Csiba L; Paschen W
Regional pH and electrolyte homeostasis of cat brain after prolonged ischemia.
Neurochemical pathology 1988;9():127-37.
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1988: Paschen W; Schmidt-Kastner R; Hallmayer J; Djuricic B
Polyamines in cerebral ischemia.
Neurochemical pathology 1988;9():1-20.
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1988: Paschen W; Röhn G; Meese C O; Djuricic B; Schmidt-Kastner R
Polyamine metabolism in reversible cerebral ischemia: effect of alpha-difluoromethylornithine.
Brain research 1988;453(1-2):9-16.
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1988: Paschen W; Hallmayer J; Röhn G
Relationship between putrescine content and density of ischemic cell damage in the brain of mongolian gerbils: effect of nimodipine and barbiturate.
Acta neuropathologica 1988;76(4):388-94.
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1987: Paschen W; Hallmayer J; Mies G
Regional profile of polyamines in reversible cerebral ischemia of Mongolian gerbils.
Neurochemical pathology 1987;7(2):143-56.
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1987: Paschen W; Schmidt-Kastner R; Djuricic B; Meese C; Linn F; Hossmann K A
Polyamine changes in reversible cerebral ischemia.
Journal of neurochemistry 1987;49(1):35-7.
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1987: Linn F; Paschen W; Ophoff B G; Hossmann K A
Mitochondrial respiration during recirculation after prolonged ischemia in cat brain.
Experimental neurology 1987;96(2):321-33.
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1987: Paschen W; Djuricic B; Mies G; Schmidt-Kastner R; Linn F
Lactate and pH in the brain: association and dissociation in different pathophysiological states.
Journal of neurochemistry 1987;48(1):154-9.
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1986: Paschen W; van den Kerchhoff W; Hossmann K A
Glycerol as an indicator of lipid degradation in bicuculline-induced seizures and experimental cerebral ischemia.
Metabolic brain disease 1986;1(1):37-44.
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