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Ralf Paschke

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Reverse Transcriptase Polymerase Chain Reaction

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Carolina Ferraz; Stephan Lorenz; Ralf Paschke; Bartosz Wojtas; Stefan R Bornstein; Markus Eszlinger
Inverse correlation of miRNA and cell cycle-associated genes suggests influence of miRNA on benign thyroid nodule tumorigenesis.
J Schaarschmidt; M Özerden; S Paschke; Markus Eszlinger; S Huth; H Jäschke; J Meller; Ralf Paschke
Late manifestation of subclinical hyperthyroidism after goitrogenesis in an index patient with a N670S TSH receptor germline mutation masquerading as TSH receptor antibody negative Graves' disease.
Carolina Ferraz; Laszlo Hegedüs; Annelise Krogdahl; Frank Narz; Ralf Paschke; Eva Magrethe Precht Jensen; Christian Rehfeld; Eileen Bösenberg; Markus Eszlinger
Detection of PAX8/PPARG and RET/PTC rearrangements is feasible in routine air-dried fine needle aspiration smears.

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2013: Carolina Ferraz; Stephan Lorenz; Ralf Paschke; Bartosz Wojtas; Stefan R Bornstein; Markus Eszlinger
Inverse correlation of miRNA and cell cycle-associated genes suggests influence of miRNA on benign thyroid nodule tumorigenesis.
The Journal of clinical endocrinology and metabolism 2013;98(1):E8-16.
2012: J Schaarschmidt; M Özerden; S Paschke; Markus Eszlinger; S Huth; H Jäschke; J Meller; Ralf Paschke
Late manifestation of subclinical hyperthyroidism after goitrogenesis in an index patient with a N670S TSH receptor germline mutation masquerading as TSH receptor antibody negative Graves' disease.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2012;44(13):962-5.
2012: Carolina Ferraz; Laszlo Hegedüs; Annelise Krogdahl; Frank Narz; Ralf Paschke; Eva Magrethe Precht Jensen; Christian Rehfeld; Eileen Bösenberg; Markus Eszlinger
Detection of PAX8/PPARG and RET/PTC rearrangements is feasible in routine air-dried fine needle aspiration smears.
Thyroid : official journal of the American Thyroid Association 2012;22(10):1025-30.
2011: Ralf Paschke
Molecular pathogenesis of nodular goiter.
Langenbeck's archives of surgery / Deutsche Gesellschaft für Chirurgie 2011;396(8):1127-36.
2011: Sandra Mueller; Ralf Paschke; Jörg Schaarschmidt; Mariusz W Szkudlinski; Robert Günther; Holger Jaeschke
Identification of novel TSH interaction sites by systematic binding analysis of the TSHR hinge region.
Endocrinology 2011;152(8):3268-78.
2011: S Sancak; L S Sen; Z Sever; O Tarcin; S Akalin; Rifat Bircan; F Eren; Hulya Gozu; B Guellueoglu; Holger Jaeschke; T Ozlem; Ralf Paschke; Markus Eszlinger
High prevalence of TSHR/Gsα mutation-negative clonal hot thyroid nodules (HNs) in a Turkish cohort.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2011;43(8):562-8.
2011: Carolina Ferraz; Markus Eszlinger; Ralf Paschke
Current state and future perspective of molecular diagnosis of fine-needle aspiration biopsy of thyroid nodules.
The Journal of clinical endocrinology and metabolism 2011;96(7):2016-26.
2011: Gunnar Kleinau; Anne Diehl; Paul Grzesik; Holger Jaeschke; Sandra Mueller; Susanne Neumann; Ralf Paschke; Gerd Krause
Defining structural and functional dimensions of the extracellular thyrotropin receptor region.
The Journal of biological chemistry 2011;286(25):22622-31.
2011: Holger Jaeschke; J Lueblinghoff; R Coslovsky; Markus Eszlinger; Ralf Paschke
Prolonged inappropriate TSH suppression during hypothyroidism after thyroid ablation in a patient with nonautoimmune familial hyperthyroidism.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2011;43(7):500-4.
2011: Ralf Paschke; Laszlo Hegedüs; Erik Alexander; Roberto Valcavi; Enrico Papini; Hossein Gharib
Thyroid nodule guidelines: agreement, disagreement and need for future research.
Nature reviews. Endocrinology 2011;7(6):354-61.
2011: J Singer; Markus Eszlinger; J Wicht; Ralf Paschke
Evidence for a more pronounced effect of genetic predisposition than environmental factors on goitrogenesis by a case control study in an area with low normal iodine supply.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2011;43(5):349-54.
2011: Ralf Paschke
Nodulogenesis and goitrogenesis.
Annales d'endocrinologie 2011;72(2):117-9.
2011: Thomas Lincke; G Orschekowski; J Singer; Osama Sabri; Ralf Paschke
Increased gallium-68 DOTATOC uptake in normal thyroid glands.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2011;43(4):282-6.
2011: Julia Lueblinghoff; Markus Eszlinger; Holger Jaeschke; Sandra Mueller; Rifat Bircan; Hulya Gozu; Seda Sancak; Sema Akalin; Ralf Paschke
Shared sporadic and somatic thyrotropin receptor mutations display more active in vitro activities than familial thyrotropin receptor mutations.
Thyroid : official journal of the American Thyroid Association 2011;21(3):221-9.
2010: Holger Jaeschke; Sandra Mueller; Markus Eszlinger; Ralf Paschke
Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas.
Clinical endocrinology 2010;73(6):815-20.
2010: Ralf Paschke; Florian Gerhard Wuthe; Katja Kühn; Claudia Jochmann; Peter Wiedemann
[Comparison of risk factors and guideline oriented prevention and therapy of diabetic retinopathy between type 2 diabetes patients undergoing laser therapy and type 2 diabetes outpatients].
Medizinische Klinik (Munich, Germany : 1983) 2010;105(11):772-8.
2010: J Singer; F Werner; Christian A Koch; Michael Bartels; Thomas Aigner; Thomas Lincke; Mathias Fasshauer; Ralf Paschke
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2010;118(8):524-9.
2010: Ralf Paschke; Theo Visser
Clinical application and consequences of molecular genetics of thyroid diseases.
Molecular and cellular endocrinology 2010;322(1-2):1.
2010: Markus Eszlinger; Ralf Paschke
Molecular fine-needle aspiration biopsy diagnosis of thyroid nodules by tumor specific mutations and gene expression patterns.
Molecular and cellular endocrinology 2010;322(1-2):29-37.
2010: Ralf Paschke
[Drowning in a sea of thyroid nodules? Prevention and selection which nodules should undergo fine needle aspiration biopsy].
MMW Fortschritte der Medizin 2010;152(13):41-4.
2010: J Lueblinghoff; Sandra Mueller; J Sontheimer; Ralf Paschke
Lack of consistent association of thyrotropin receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism.
Journal of endocrinological investigation 2010;33(4):228-33.
2010: Stephan Lorenz; Markus Eszlinger; Ralf Paschke; Gabriela Aust; Michael Weick; Dagmar Führer; Knut Krohn
Calcium signaling of thyrocytes is modulated by TSH through calcium binding protein expression.
Biochimica et biophysica acta 2010;1803(3):352-60.
2010: Ralf Paschke; Kurt Werner Schmid; Roland Gärtner; Klaus Mann; Henning Dralle; Christoph Reiners
[Epidemiology, pathophysiology, guideline-adjusted diagnostics, and treatment of thyroid nodules].
Medizinische Klinik (Munich, Germany : 1983) 2010;105(2):80-7.
2010: Sandra Mueller; Holger Jaeschke; Robert Günther; Ralf Paschke
The hinge region: an important receptor component for GPHR function.
Trends in endocrinology and metabolism: TEM 2010;21(2):111-22.
2010: Markus Eszlinger; Kurt Werner Schmid; Ralf Paschke
Clinical implications of molecular studies for the diagnosis of thyroid cancer.
Hormones (Athens, Greece) 2010;9(1):51-6.
2010: Gunnar Kleinau; Holger Jaeschke; Catherine L Worth; Sandra Mueller; Jorge Gonzalez; Ralf Paschke; Gerd Krause
Principles and determinants of G-protein coupling by the rhodopsin-like thyrotropin receptor.
PloS one 2010;5(3):e9745.
2009: Ralf Paschke
[Diagnostic work-up of euthyroid nodules: which nodules should undergo fine-needle aspiration biopsy? Relevance of ultrasound].
Deutsche medizinische Wochenschrift (1946) 2009;134(49):2498-503.
2009: S Sancak; A Hardt; Albert M Ricken; Stephan Lorenz; Markus Eszlinger; L S Sen; B M Güllüoglu; Z Sever; F T Eren; N S Akalin; Ralf Paschke
Increased percentage of microvessels but decreased density of large vessels in papillary carcinomas as compared to hot and cold thyroid nodules.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2009;117(10):637-44.
2009: Sandra Mueller; Hulya Iliksu Gozu; Rifat Bircan; Holger Jaeschke; Markus Eszlinger; Julia Lueblinghoff; Knut Krohn; Ralf Paschke
Cases of borderline in vitro constitutive thyrotropin receptor activity: how to decide whether a thyrotropin receptor mutation is constitutively active or not?
Thyroid : official journal of the American Thyroid Association 2009;19(7):765-73.
2009: Sandra Mueller; Gunnar Kleinau; Mariusz W Szkudlinski; Holger Jaeschke; Gerd Krause; Ralf Paschke
The superagonistic activity of bovine thyroid-stimulating hormone (TSH) and the human TR1401 TSH analog is determined by specific amino acids in the hinge region of the human TSH receptor.
The Journal of biological chemistry 2009;284(24):16317-24.
2009: Thomas Lincke; Joerg Singer; Regine Kluge; Osama Sabri; Ralf Paschke
Relative quantification of indium-111 pentetreotide and gallium-68 DOTATOC uptake in the thyroid gland and association with thyroid pathologies.
Thyroid : official journal of the American Thyroid Association 2009;19(4):381-9.
2009: Laszlo Hegedüs; Thomas Brix; Ralf Paschke
Etiology of simple goiter.
Thyroid : official journal of the American Thyroid Association 2009;19(3):209-11.
2008: Holger Jaeschke; Gunnar Kleinau; J Sontheimer; Sandra Mueller; Gerd Krause; Ralf Paschke
Preferences of transmembrane helices for cooperative amplification of G(alpha)s and G (alpha)q signaling of the thyrotropin receptor.
Cellular and molecular life sciences : CMLS 2008;65(24):4028-38.
2008: Gunnar Kleinau; Holger Jaeschke; Sandra Mueller; C L Worth; Ralf Paschke; Gerd Krause
Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.
Cellular and molecular life sciences : CMLS 2008;65(22):3664-76.
2008: Marianthi Georgitsi; Elina Heliövaara; Ralf Paschke; Ajith V K Kumar; Marc Tischkowitz; Outi Vierimaa; Pasi Salmela; Timo Sane; Ernesto De Menis; Serafinella P Cannavò; Sadi Gündogdu; Anneke Lucassen; Louise Izatt; Simon Aylwin; Gul Bano; Shirley Hodgson; Christian A Koch; Auli Karhu; Lauri A Aaltonen
Large genomic deletions in AIP in pituitary adenoma predisposition.
The Journal of clinical endocrinology and metabolism 2008;93(10):4146-51.
2008: Marianthi Georgitsi; Ernesto De Menis; Serafinella P Cannavò; Markus Makinen; Karoliina Tuppurainen; Paolo Pauletto; Lorenzo Curtò; Robert J Weil; Ralf Paschke; Grzegorz Zielinski; Anna Wasik; Jan Lubinski; Pia Vahteristo; Auli Karhu; Lauri A Aaltonen
Aryl hydrocarbon receptor interacting protein (AIP) gene mutation analysis in children and adolescents with sporadic pituitary adenomas.
Clinical endocrinology 2008;69(4):621-7.
2008: Markus Eszlinger; Knut Krohn; Steffen Hauptmann; Henning Dralle; Thomas J Giordano; Ralf Paschke
Perspectives for improved and more accurate classification of thyroid epithelial tumors.
The Journal of clinical endocrinology and metabolism 2008;93(9):3286-94.
2008: Gunnar Kleinau; Holger Jaeschke; Sandra Mueller; Bruce M Raaka; Susanne Neumann; Ralf Paschke; Gerd Krause
Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(8):2798-808.
2008: Sandra Mueller; Gunnar Kleinau; Holger Jaeschke; Ralf Paschke; Gerd Krause
Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation.
The Journal of biological chemistry 2008;283(26):18048-55.
2008: R Bircan; Konstanze Miehle; G Mladenova; R Ivanova; R Ivanova; A Sarafova; A-M Borissova; J Lüblinghoff; Ralf Paschke
Multiple relapses of hyperthyroidism after thyroid surgeries in a patient with long term follow-up of sporadic non-autoimmune hyperthyroidism.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116(6):341-6.
2008: Hulya Gozu; Sandra Mueller; Rifat Bircan; Knut Krohn; Gazenfer Ekinci; Dilek Yavuzer; Haluk Sargin; Mehmet Sargin; Tunc Ones; Cem Gezen; Ekrem Orbay; Beyazit Cirakoglu; Ralf Paschke
A new silent germline mutation of the TSH receptor: coexpression in a hyperthyroid family member with a second activating somatic mutation.
Thyroid : official journal of the American Thyroid Association 2008;18(5):499-508.
2007: Stefan Falk; Jürgen Kratzsch; Ralf Paschke; Christian A Koch
Hypercalcemia as a result of sarcoidosis with normal serum concentrations of vitamin D.
Medical science monitor : international medical journal of experimental and clinical research 2007;13(11):CS133-136.
2007: Carsten Voigt; C Prodinger; Ralf Paschke
The TSH receptor is linked with AP1 and NFkappaB signaling in COS7 cells.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007;115(9):590-3.
2007: Markus Eszlinger; Holger Jaeschke; Ralf Paschke
Insights from molecular pathways: potential pharmacologic targets of benign thyroid nodules.
Current opinion in endocrinology, diabetes, and obesity 2007;14(5):393-7.
2007: Knut Krohn; Jacqueline Maier; Ralf Paschke
Mechanisms of disease: hydrogen peroxide, DNA damage and mutagenesis in the development of thyroid tumors.
Nature clinical practice. Endocrinology & metabolism 2007;3(10):713-20.
2007: Krzysztof Fujarewicz; Michal Jarzab; Markus Eszlinger; Knut Krohn; Ralf Paschke; Malgorzata Oczko-Wojciechowska; Malgorzata Wiench; Aleksandra Kukulska; Barbara Jarzab; Andrzej Swierniak
A multi-gene approach to differentiate papillary thyroid carcinoma from benign lesions: gene selection using support vector machines with bootstrapping.
Endocrine-related cancer 2007;14(3):809-26.
2007: Ralf Paschke
32(nd) Annual Meeting of the European Thyroid Association in Leipzig, Germany.
Thyroid : official journal of the American Thyroid Association 2007;17(7):601.
2007: Romy Kursawe; Ralf Paschke
Modulation of TSHR signaling by posttranslational modifications.
Trends in endocrinology and metabolism: TEM 2007;18(5):199-207.
2007: Yvonne Böttcher; Thomas Paufler; Thomas Stehr; Frank Ludwig Bertschat; Ralf Paschke; Christian A Koch
Thyroid hormone resistance without mutations in thyroid hormone receptor beta.
Medical science monitor : international medical journal of experimental and clinical research 2007;13(6):CS67-70.
2007: J Maier; H van Steeg; Conny Th M van Oostrom; Ralf Paschke; R E Weiss; Knut Krohn
Iodine deficiency activates antioxidant genes and causes DNA damage in the thyroid gland of rats and mice.
Biochimica et biophysica acta 2007;1773(6):990-9.
2007: Markus Eszlinger; Knut Krohn; Aleksandra Kukulska; Barbara Jarzab; Ralf Paschke
Perspectives and limitations of microarray-based gene expression profiling of thyroid tumors.
Endocrine reviews 2007;28(3):322-38.
2007: Stephan Lorenz; Romy Frenzel; Ralf Paschke; Gerda E Breitwieser; Susanne U Miedlich
Functional desensitization of the extracellular calcium-sensing receptor is regulated via distinct mechanisms: role of G protein-coupled receptor kinases, protein kinase C and beta-arrestins.
Endocrinology 2007;148(5):2398-404.
2007: Ralf Paschke
[Thyroid nodules].
MMW Fortschritte der Medizin 2007;149(13):39-43; quiz 44.
2007: Marianthi Georgitsi; Anniina Raitila; Auli Karhu; Karoliina Tuppurainen; Markus Makinen; Outi Vierimaa; Ralf Paschke; Wolfgang Saeger; Rob B van der Luijt; Timo Sane; Mercedes Robledo; Ernesto De Menis; Robert J Weil; Anna Wasik; Grzegorz Zielinski; Olga Lucewicz; Jan Lubinski; Virpi Launonen; Pia Vahteristo; Lauri A Aaltonen
Molecular diagnosis of pituitary adenoma predisposition caused by aryl hydrocarbon receptor-interacting protein gene mutations.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4101-5.
2007: Susan Kralisch; Ulrike Lossner; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Growth hormone induces apelin mRNA expression and secretion in mouse 3T3-L1 adipocytes.
Regulatory peptides 2007;139(1-3):84-9.
2007: Susan Kralisch; Matthias Blüher; Anke Tönjes; Ulrike Lossner; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Tissue inhibitor of metalloproteinase-1 predicts adiposity in humans.
European journal of endocrinology / European Federation of Endocrine Societies 2007;156(2):257-61.
2007: Gunnar Kleinau; Maren Claus; Holger Jaeschke; Sandra Mueller; Susanne Neumann; Ralf Paschke; Gerd Krause
Contacts between extracellular loop two and transmembrane helix six determine basal activity of the thyroid-stimulating hormone receptor.
The Journal of biological chemistry 2007;282(1):518-25.
2007: Susan Kralisch; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Adipokines and adipocyte targets in the future management of obesity and the metabolic syndrome.
Mini reviews in medicinal chemistry 2007;7(1):39-45.
2006: V F H Brauer; Ulrich Schweizer; Josef Köhrle; Ralf Paschke
Selenium and goiter prevalence in borderline iodine sufficiency.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(6):807-12.
2006: Kerstin Krause; Angelika Schierhorn; Andrea Sinz; Johannes-Dieter Wissmann; Annette G Beck-Sickinger; Ralf Paschke; Dagmar Führer
Toward the application of proteomics to human thyroid tissue.
Thyroid : official journal of the American Thyroid Association 2006;16(11):1131-43.
2006: Ralf Paschke
[Increased levels of auto-antibodies in thyroid diagnostics: Hashimoto thyroidities or Graves disease?].
Der Internist 2006;47(11):1193-4.
2006: Maren Claus; Susanne Neumann; Gunnar Kleinau; Gerd Krause; Ralf Paschke
Structural determinants for G-protein activation and specificity in the third intracellular loop of the thyroid-stimulating hormone receptor.
Journal of molecular medicine (Berlin, Germany) 2006;84(11):943-54.
2006: Sandra Mueller; Gunnar Kleinau; Holger Jaeschke; Susanne Neumann; Gerd Krause; Ralf Paschke
Significance of ectodomain cysteine boxes 2 and 3 for the activation mechanism of the thyroid-stimulating hormone receptor.
The Journal of biological chemistry 2006;281(42):31638-46.
2006: Anke Tönjes; Stefan Karger; Christian A Koch; Ralf Paschke; Andrea Tannapfel; Michael Stumvoll; Dagmar Führer
Impaired enteral levothyroxine absorption in hypothyroidism refractory to oral therapy after thyroid ablation for papillary thyroid cancer: case report and kinetic studies.
Thyroid : official journal of the American Thyroid Association 2006;16(10):1047-51.
2006: Hulya Gozu; Rifat Bircan; Knut Krohn; Sandra Müller; Selahattin Vural; Cem Gezen; Haluk Sargin; Dilek Yavuzer; Mehmet Sargin; Beyazit Cirakoglu; Ralf Paschke
Similar prevalence of somatic TSH receptor and Gsalpha mutations in toxic thyroid nodules in geographical regions with different iodine supply in Turkey.
European journal of endocrinology / European Federation of Endocrine Societies 2006;155(4):535-45.
2006: Susan Kralisch; Johannes Klein; Ulrike Lossner; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Isoproterenol stimulates monocyte chemoattractant protein-1 expression and secretion in 3T3-L1 adipocytes.
Regulatory peptides 2006;135(1-2):12-6.
2006: Susan Kralisch; Johannes Klein; Ulrike Lossner; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Plasminogen activator inhibitor-1 expression and secretion are stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes.
Molecular and cellular endocrinology 2006;253(1-2):56-62.
2006: J Maier; H van Steeg; Conny Th M van Oostrom; Stefan Karger; Ralf Paschke; Knut Krohn
Deoxyribonucleic acid damage and spontaneous mutagenesis in the thyroid gland of rats and mice.
Endocrinology 2006;147(7):3391-7.
2006: Susanna Moore; Holger Jaeschke; Gunnar Kleinau; Susanne Neumann; Stefano Costanzi; Jian-Kang Jiang; John Childress; Bruce M Raaka; Anny-Odile Colson; Ralf Paschke; Gerd Krause; Craig J Thomas; Marvin C Gershengorn
Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.
Journal of medicinal chemistry 2006;49(13):3888-96.
2006: K Uhlmann; Peter Kovacs; Yvonne Böttcher; Hans-Peter Hammes; Ralf Paschke
Genetics of diabetic retinopathy.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2006;114(6):275-94.
2006: Susan Kralisch; Ulrike Lossner; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Tissue inhibitor of metalloproteinase 1 expression and secretion are induced by beta-adrenergic stimulation in 3T3-L1 adipocytes.
The Journal of endocrinology 2006;189(3):665-70.
2006: Romy Frenzel; Carsten Voigt; Ralf Paschke
The human thyrotropin receptor is predominantly internalized by beta-arrestin 2.
Endocrinology 2006;147(6):3114-22.
2006: Outi Vierimaa; Marianthi Georgitsi; Rainer Lehtonen; Pia Vahteristo; Antti Kokko; Anniina Raitila; Karoliina Tuppurainen; Tapani Ebeling; Pasi Salmela; Ralf Paschke; Sadi Gündogdu; Ernesto De Menis; Markus Makinen; Virpi Launonen; Auli Karhu; Lauri A Aaltonen
Pituitary adenoma predisposition caused by germline mutations in the AIP gene.
Science (New York, N.Y.) 2006;312(5777):1228-30.
2006: Markus Eszlinger; Malgorzata Wiench; Barbara Jarzab; Knut Krohn; Martin Beck; Jürgen Läuter; Elzbieta Gubała; Krzysztof Fujarewicz; Andrzej Swierniak; Ralf Paschke
Meta- and reanalysis of gene expression profiles of hot and cold thyroid nodules and papillary thyroid carcinoma for gene groups.
The Journal of clinical endocrinology and metabolism 2006;91(5):1934-42.
2006: Holger Jäschke; Susanne Neumann; Susanna Moore; Craig J Thomas; Anny-Odile Colson; Stefano Costanzi; Gunnar Kleinau; Jian-Kang Jiang; Ralf Paschke; Bruce M Raaka; Gerd Krause; Marvin C Gershengorn
A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).
The Journal of biological chemistry 2006;281(15):9841-4.
2006: Andreas Oberbach; Yvonne Bossenz; Stefanie Lehmann; Josef Niebauer; Volker Adams; Ralf Paschke; Michael R Schön; Matthias Blüher; Karla Punkt
Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes.
Diabetes care 2006;29(4):895-900.
2006: Andreas Oberbach; Anke Tönjes; Nora Klöting; Mathias Fasshauer; Jürgen Kratzsch; Martin W Busse; Ralf Paschke; Michael Stumvoll; Matthias Blüher
Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance.
European journal of endocrinology / European Federation of Endocrine Societies 2006;154(4):577-85.
2006: Holger Jaeschke; Susanne Neumann; Gunnar Kleinau; Sandra Mueller; Maren Claus; Gerd Krause; Ralf Paschke
An aromatic environment in the vicinity of serine 281 is a structural requirement for thyrotropin receptor function.
Endocrinology 2006;147(4):1753-60.
2006: Markus Eszlinger; Knut Krohn; Martin Beck; David Kipling; Sarah Forbes-Robertson; Jürgen Läuter; Anke Tönjes; David Wynford-Thomas; Ralf Paschke
Comparison of differential gene expression of hot and cold thyroid nodules with primary epithelial cell culture models by investigation of co-regulated gene sets.
Biochimica et biophysica acta 2006;1763(3):263-71.
2006: V F H Brauer; H Below; A Kramer; Dagmar Führer; Ralf Paschke
The role of thiocyanate in the etiology of goiter in an industrial metropolitan area.
European journal of endocrinology / European Federation of Endocrine Societies 2006;154(2):229-35.
2006: Christian A Koch; Frederieke M Brouwers; Alexander O Vortmeyer; Andrea Tannapfel; Steven Libutti; Zhengping Zhuang; Karel Pacak; Hartmut P H Neumann; Ralf Paschke
Somatic VHL gene alterations in MEN2-associated medullary thyroid carcinoma.
BMC cancer 2006;6():131.
2006: Mathias Fasshauer; Thomas Lincke; Helmut Witzigmann; Regine Kluge; Andrea Tannapfel; Michael Moche; Michael Buchfelder; Stephan Petersenn; Jürgen Kratzsch; Ralf Paschke; Christian A Koch
Ectopic Cushing' syndrome caused by a neuroendocrine carcinoma of the mesentery.
BMC cancer 2006;6():108.
2005: Konstanze Miehle; Jürgen Kratzsch; Jacques W M Lenders; Regine Kluge; Ralf Paschke; Christian A Koch
Adrenal incidentaloma diagnosed as pheochromocytoma by plasma chromogranin A and plasma metanephrines.
Journal of endocrinological investigation 2005;28(11):1040-2.
2005: Thorsten Klemm; A K Mehnert; Annelie Siegemund; Tobias D Wiesner; Götz Gelbrich; Matthias Blüher; Ralf Paschke
Impact of the Thr789Ala variant of the von Willebrand factor levels, on ristocetin co-factor and collagen binding capacity and its association with coronary heart disease in patients with diabetes mellitus type 2.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2005;113(10):568-72.
2005: Maren Claus; Holger Jaeschke; Gunnar Kleinau; Susanne Neumann; Gerd Krause; Ralf Paschke
A hydrophobic cluster in the center of the third extracellular loop is important for thyrotropin receptor signaling.
Endocrinology 2005;146(12):5197-203.
2005: Susan Kralisch; Johannes Klein; Ulrike Lossner; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Proinflammatory adipocytokines induce TIMP-1 expression in 3T3-L1 adipocytes.
FEBS letters 2005;579(28):6417-22.
2005: V F H Brauer; P Eder; K Miehle; T D Wiesner; H Hasenclever; Ralf Paschke
Interobserver variation for ultrasound determination of thyroid nodule volumes.
Thyroid : official journal of the American Thyroid Association 2005;15(10):1169-75.
2005: Matthias Blüher; Mathias Fasshauer; Anke Tönjes; Jürgen Kratzsch; Michael R Schön; Ralf Paschke
Association of interleukin-6, C-reactive protein, interleukin-10 and adiponectin plasma concentrations with measures of obesity, insulin sensitivity and glucose metabolism.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2005;113(9):534-7.
2005: Romy Frenzel; Knut Krohn; Markus Eszlinger; Anke Tönjes; Ralf Paschke
Sialylation of human thyrotropin receptor improves and prolongs its cell-surface expression.
Molecular pharmacology 2005;68(4):1106-13.
2005: Susan Kralisch; Johannes Klein; Ulrike Lossner; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes.
American journal of physiology. Endocrinology and metabolism 2005;289(4):E586-90.
2005: Maren Claus; Jacqueline Maier; Ralf Paschke; Christoph Kujat; Michael Stumvoll; Dagmar Führer
Novel thyrotropin receptor germline mutation (Ile568Val) in a Saxonian family with hereditary nonautoimmune hyperthyroidism.
Thyroid : official journal of the American Thyroid Association 2005;15(9):1089-94.
2005: Stefan Karger; Kerstin Berger; Markus Eszlinger; Andrea Tannapfel; Henning Dralle; Ralf Paschke; Dagmar Führer
Evaluation of peroxisome proliferator-activated receptor-gamma expression in benign and malignant thyroid pathologies.
Thyroid : official journal of the American Thyroid Association 2005;15(9):997-1003.
2005: Yvonne Böttcher; Markus Eszlinger; Anke Tönjes; Ralf Paschke
The genetics of euthyroid familial goiter.
Trends in endocrinology and metabolism: TEM 2005;16(7):314-9.
2005: Knut Krohn; Markus Eszlinger; Ralf Paschke; Ingo Roeder; E Schuster
Increased power of microarray analysis by use of an algorithm based on a multivariate procedure.
Bioinformatics (Oxford, England) 2005;21(17):3530-4.
2005: Susan Kralisch; Johannes Klein; Ulrike Lossner; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Isoproterenol, TNFalpha, and insulin downregulate adipose triglyceride lipase in 3T3-L1 adipocytes.
Molecular and cellular endocrinology 2005;240(1-2):43-9.
2005: Ralf Paschke; Christoph Reiners; Dagmar Führer; Kurt W Schmid; Henning Dralle; G Brabant
[Recommendations and unanswered questions in the diagnosis and treatment of thyroid nodules. Opinion of the Thyroid Section of the German Society for Endocrinology].
Deutsche medizinische Wochenschrift (1946) 2005;130(31-32):1831-6.
2005: Susan Kralisch; Johannes Klein; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Therapeutic perspectives of adipocytokines.
Expert opinion on pharmacotherapy 2005;6(6):863-72.
2005: Susan Kralisch; Johannes Klein; Ulrike Lossner; Matthias Blüher; Ralf Paschke; Michael Stumvoll; Mathias Fasshauer
Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes.
The Journal of endocrinology 2005;185(3):R1-8.
2005: Knut Krohn; Dagmar Führer; Yvonne Bayer; Markus Eszlinger; V F H Brauer; Susanne Neumann; Ralf Paschke
Molecular pathogenesis of euthyroid and toxic multinodular goiter.
Endocrine reviews 2005;26(4):504-24.
2005: Dagmar Führer; Christian A Koch; Christos Trantakis; A Taunapfel; Ralf Paschke
TSHoma with low alpha subunit in a patient with long-standing asymptomatic hyperthyroidism.
Thyroid : official journal of the American Thyroid Association 2005;15(5):489-90.
2005: Dagmar Führer; Markus Eszlinger; Stefan Karger; Kerstin Krause; C Engelhardt; Dirk Hasenclever; Henning Dralle; Ralf Paschke
Evaluation of insulin-like growth factor II, cyclooxygenase-2, ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(5):785-90.
2005: Anke Tönjes; Ralf Paschke
[Diagnosis and therapy of thyroid nodules].
Der Internist 2005;46(5):565-72; quiz 573-4.
2005: Tobias D Wiesner; Christos Trantakis; Jürgen Meixensberger; Christian A Koch; Claus Zimmer; Ralf Paschke
[Structure of an interdisciplinary pituitary outpatient care unit at the University Hospital of Leipzig and results for treatment of prolactin and growth hormone secreting pituitary tumors].
Medizinische Klinik (Munich, Germany : 1983) 2005;100(4):173-9.
2005: Matthias Blüher; Mathias Fasshauer; Susan Kralisch; Michael R Schön; Knut Krohn; Ralf Paschke
Regulation of adiponectin receptor R1 and R2 gene expression in adipocytes of C57BL/6 mice.
Biochemical and biophysical research communications 2005;329(3):1127-32.
2005: Hulya Gozu; Melike Avsar; Rifat Bircan; Maren Claus; Serap Sahin; Ozlem Sezgin; Oguzhan Deyneli; Ralf Paschke; Beyazit Cirakoglu; Sema Akalin
Two novel mutations in the sixth transmembrane segment of the thyrotropin receptor gene causing hyperfunctioning thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2005;15(4):389-97.
2005: V F H Brauer; W H Brauer; Dagmar Führer; Ralf Paschke
Iodine nutrition, nodular thyroid disease, and urinary iodine excretion in a German university study population.
Thyroid : official journal of the American Thyroid Association 2005;15(4):364-70.
2005: Susanne Neumann; Maren Claus; Ralf Paschke
Interactions between the extracellular domain and the extracellular loops as well as the 6th transmembrane domain are necessary for TSH receptor activation.
European journal of endocrinology / European Federation of Endocrine Societies 2005;152(4):625-34.
2005: Dagmar Führer; C Mügge; Ralf Paschke
Questionnaire on management of nodular thyroid disease (Annual Meeting of the Thyroid Section of the German Society of Endocrinology 2003).
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2005;113(3):152-9.
2005: Anke Tönjes; Yvonne Böttcher; Susanne Neumann; Konstanze Miehle; V F H Brauer; Ralf Paschke
[Elucidation of genetic predisposition of euthyroid goiter using linkage- and association analyses].
Deutsche medizinische Wochenschrift (1946) 2005;130(7):340-3.
2005: Carsten Voigt; Hans-Peter Holzapfel; Ralf Paschke
Decreased expression of G-protein coupled receptor kinase 2 in cold thyroid nodules.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2005;113(2):102-6.
2005: Markus Eszlinger; Knut Krohn; Kerstin Berger; Jürgen Läuter; Siegfried Kropf; Martin Beck; Dagmar Führer; Ralf Paschke
Gene expression analysis reveals evidence for increased expression of cell cycle-associated genes and Gq-protein-protein kinase C signaling in cold thyroid nodules.
The Journal of clinical endocrinology and metabolism 2005;90(2):1163-70.
2005: Susanne Neumann; Gerd Krause; Maren Claus; Ralf Paschke
Structural determinants for g protein activation and selectivity in the second intracellular loop of the thyrotropin receptor.
Endocrinology 2005;146(1):477-85.
2004: Gunnar Kleinau; Holger Jäschke; Susanne Neumann; Jens Lättig; Ralf Paschke; Gerd Krause
Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface.
The Journal of biological chemistry 2004;279(49):51590-600.
2004: Mathias Fasshauer; Johannes Klein; Susan Kralisch; Margit Klier; Ulrike Lossner; Matthias Blüher; Ralf Paschke
Serum amyloid A3 expression is stimulated by dexamethasone and interleukin-6 in 3T3-L1 adipocytes.
The Journal of endocrinology 2004;183(3):561-7.
2004: Kerstin Berger; D Wissmann; Christian Ihling; Stefan Kalkhof; Annette G Beck-Sickinger; Andrea Sinz; Ralf Paschke; Dagmar Führer
Quantitative proteome analysis in benign thyroid nodular disease using the fluorescent ruthenium II tris(bathophenanthroline disulfonate) stain.
Molecular and cellular endocrinology 2004;227(1-2):21-30.
2004: Anke Tönjes; Susanne U Miedlich; Hans-Peter Holzapfel; Markus Eszlinger; Cord Arkenau; Ralf Paschke
Expression of regulators of g protein signaling mRNA is differentially regulated in hot and cold thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2004;14(11):896-901.
2004: Mathias Fasshauer; Ralf Paschke; Michael Stumvoll
Adiponectin, obesity, and cardiovascular disease.
Biochimie 2004;86(11):779-84.
2004: V F H Brauer; Ralf Paschke
[Molecular aetiology of nodular goitre -- consequences for therapy?].
Zentralblatt für Chirurgie 2004;129(5):356-62.
2004: Markus Eszlinger; Hans-Peter Holzapfel; Carsten Voigt; Cord Arkenau; Ralf Paschke
RGS 2 expression is regulated by TSH and inhibits TSH receptor signaling.
European journal of endocrinology / European Federation of Endocrine Societies 2004;151(3):383-90.
2004: Kirsten G Meyer; Mathias Fasshauer; Istvan-Tibor Nebel; Ralf Paschke
Comparative analysis of conventional training and a computer-based interactive training program for celiac disease patients.
Patient education and counseling 2004;54(3):353-60.
2004: Yvonne Bayer; Susanne Neumann; Birgit Meyer; Franz Rüschendorf; Andreas Reske; Thomas Brix; Laszlo Hegedüs; Pavel Langer; Peter Nürnberg; Ralf Paschke
Genome-wide linkage analysis reveals evidence for four new susceptibility loci for familial euthyroid goiter.
The Journal of clinical endocrinology and metabolism 2004;89(8):4044-52.
2004: Konstanze Miehle; Andrea Tannapfel; Peter Lamesch; Gudrun Borte; Eva Schenker; Regine Kluge; Rudolf Ott; Volker Wiechmann; Martin Koch; Woubet T Kassahun; Ralf Paschke; Christian A Koch
Pancreatic neuroendocrine tumor with ectopic adrenocorticotropin production upon second recurrence.
The Journal of clinical endocrinology and metabolism 2004;89(8):3731-6.
2004: Carsten Voigt; Hans-Peter Holzapfel; Silke Meyer; Ralf Paschke
Increased expression of G-protein-coupled receptor kinases 3 and 4 in hyperfunctioning thyroid nodules.
The Journal of endocrinology 2004;182(1):173-82.
2004: C Pohlink; A Tannapfe; Uwe Eichfeld; F Schmidt; Dagmar Führer; Ralf Paschke; Christian A Koch
Does tumor heterogeneity limit the use of the Weiss criteria in the evaluation of adrenocortical tumors?
Journal of endocrinological investigation 2004;27(6):565-9.
2004: Istvan-Tibor Nebel; Thorsten Klemm; Mathias Fasshauer; Ulrich Müller; Hans-Joachim Verlohren; Antje Klaiberg; Ralf Paschke
Comparative analysis of conventional and an adaptive computer-based hypoglycaemia education programs.
Patient education and counseling 2004;53(3):315-8.
2004: Knut Krohn; Ralf Paschke
BRAF mutations are not an alternative explanation for the molecular etiology of ras-mutation negative cold thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2004;14(5):359-61.
2004: Mathias Fasshauer; Johannes Klein; Susan Kralisch; Margit Klier; Ulrike Lossner; Matthias Blüher; Ralf Paschke
Monocyte chemoattractant protein 1 expression is stimulated by growth hormone and interleukin-6 in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 2004;317(2):598-604.
2004: Mathias Fasshauer; Susan Kralisch; Margit Klier; Ulrike Lossner; Matthias Blüher; Johannes Klein; Ralf Paschke
Insulin resistance-inducing cytokines differentially regulate SOCS mRNA expression via growth factor- and Jak/Stat-signaling pathways in 3T3-L1 adipocytes.
The Journal of endocrinology 2004;181(1):129-38.
2004: Christiane Roick; Katrin Thierfelder; Dirk Heider; Thorsten Klemm; Ralf Paschke; Matthias C Angermeyer
[Quality of life instruments and health state preferences to assess effects of medical interventions for mentally and medically ill patients].
Psychiatrische Praxis 2004;31(3):128-37.
2004: Rainer U Pliquett; Mathias Fasshauer; Matthias Blüher; Ralf Paschke
Neurohumoral stimulation in type-2-diabetes as an emerging disease concept.
Cardiovascular diabetology 2004;3():4.
2004: Mathias Fasshauer; Susan Kralisch; Margit Klier; Ulrike Lossner; Matthias Blüher; Anne-Marie Chambaut-Guérin; Johannes Klein; Ralf Paschke
Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes.
FEBS letters 2004;560(1-3):153-7.
2004: Susanne Neumann; Katrin Schuchardt; Andreas Reske; Alexander Reske; Peter Emmrich; Ralf Paschke
Lack of correlation for sodium iodide symporter mRNA and protein expression and analysis of sodium iodide symporter promoter methylation in benign cold thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2004;14(2):99-111.
2004: Yvonne Bayer; Mathias Fasshauer; Ralf Paschke
The novel missense mutation methionine 442 threonine in the thyroid hormone receptor beta causes thyroid hormone resistance: a case report.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2004;112(2):95-7.
2004: Peter Lachmund; Istvan-Tibor Nebel; Dagmar Führer; Ralf Paschke
The pedigree tool: web-based visualization of a family tree.
Human mutation 2004;23(2):103-5.
2004: Mathias Fasshauer; Johannes Klein; Susan Kralisch; Margit Klier; Ulrike Lössner; Matthias Blüher; Ralf Paschke
Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes.
FEBS letters 2004;558(1-3):27-32.
2004: Markus Eszlinger; Knut Krohn; Romy Frenzel; Siegfried Kropf; Anke Tönjes; Ralf Paschke
Gene expression analysis reveals evidence for inactivation of the TGF-beta signaling cascade in autonomously functioning thyroid nodules.
Oncogene 2004;23(3):795-804.
2004: V F H Brauer; Gerhard Scholz; Susanne Neumann; Tobias Lohmann; Ralf Paschke; Christian A Koch
RET germline mutation in codon 791 in a family representing 3 generations from age 5 to age 70 years: should thyroidectomy be performed?
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 2004;10(1):5-9.
2003: Dagmar Führer; Peter Lachmund; Istvan-Tibor Nebel; Ralf Paschke
The thyrotropin receptor mutation database: update 2003.
Thyroid : official journal of the American Thyroid Association 2003;13(12):1123-6.
2003: Dagmar Führer; Andrea Tannapfel; Osama Sabri; Peter Lamesch; Ralf Paschke
Two somatic TSH receptor mutations in a patient with toxic metastasising follicular thyroid carcinoma and non-functional lung metastases.
Endocrine-related cancer 2003;10(4):591-600.
2003: Mathias Fasshauer; Ralf Paschke
Regulation of adipocytokines and insulin resistance.
Diabetologia 2003;46(12):1594-603.
2003: V F H Brauer; Bettina Hentschel; Ralf Paschke
[Euthyroid thyroid nodules. Aims, results and perspectives concerning drug therapy].
Deutsche medizinische Wochenschrift (1946) 2003;128(45):2381-7.
2003: Susanne U Miedlich; Knut Krohn; Ralf Paschke
Update on genetic and clinical aspects of primary hyperparathyroidism.
Clinical endocrinology 2003;59(5):539-54.
2003: Susanne Neumann; Yvonne Bayer; Andreas Reske; Mária Tajtáková; Pavel Langer; Ralf Paschke
Further indications for genetic heterogeneity of euthyroid familial goiter.
Journal of molecular medicine (Berlin, Germany) 2003;81(11):736-45.
2003: V F H Brauer; Ralf Paschke
[Pathophysiologic basis for prevention and pharmacotherapy of benign cold thyroid nodules].
Deutsche medizinische Wochenschrift (1946) 2003;128(44):2324-8.
2003: Matthias Blüher; Ralf Paschke
[Visceral adipose tissue and metabolic syndrome].
Deutsche medizinische Wochenschrift (1946) 2003;128(44):2319-23.
2003: Gerhard Scholz; Eva Hagemann; Cord Arkenau; Lothar Engelmann; Peter Lamesch; Dierk Schreiter; Manfred Schoenfelder; Derk Olthoff; Ralf Paschke
Is there a place for thyroidectomy in older patients with thyrotoxic storm and cardiorespiratory failure?
Thyroid : official journal of the American Thyroid Association 2003;13(10):933-40.
2003: Rainer U Pliquett; Jörg Schwock; Ralf Paschke; Harald Achenbach
Calciphylaxis in chronic, non-dialysis-dependent renal disease.
BMC nephrology 2003;4():8.
2003: Konstanze Miehle; Ralf Paschke
Therapy of hyperthyroidism.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2003;111(6):305-18.
2003: Mathias Fasshauer; Johannes Klein; S Krahlisch; U Lössner; Margit Klier; Matthias Blüher; Ralf Paschke
GH is a positive regulator of tumor necrosis factor alpha-induced adipose related protein in 3T3-L1 adipocytes.
The Journal of endocrinology 2003;178(3):523-31.
2003: Tobias D Wiesner; Matthias Blüher; M Windgassen; Ralf Paschke
Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma.
The Journal of clinical endocrinology and metabolism 2003;88(8):3632-6.
2003: Knut Krohn; Ingo Stricker; Peter Emmrich; Ralf Paschke
Cold thyroid nodules show a marked increase in proliferation markers.
Thyroid : official journal of the American Thyroid Association 2003;13(6):569-75.
2003: Mathias Fasshauer; Johannes Klein; Ulrike Lossner; Margit Klier; Susan Kralisch; Ralf Paschke
Suppression of aquaporin adipose gene expression by isoproterenol, TNFalpha, and dexamethasone.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(4):222-7.
2003: Matthias Blüher; Ralf Paschke
Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2003;111(2):85-90.
2003: Mathias Fasshauer; Johannes Klein; Ulrike Lossner; Ralf Paschke
Interleukin (IL)-6 mRNA expression is stimulated by insulin, isoproterenol, tumour necrosis factor alpha, growth hormone, and IL-6 in 3T3-L1 adipocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(3):147-52.
2003: Matthias Blüher; Georg Lübben; Ralf Paschke
Analysis of the relationship between the Pro12Ala variant in the PPAR-gamma2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes.
Diabetes care 2003;26(3):825-31.
2003: Gerasimos P Sykiotis; Susanne Neumann; Neoklis A Georgopoulos; Argyro Sgourou; Adamantia Papachatzopoulou; Kostas B Markou; Venetsana Kyriazopoulou; Ralf Paschke; Apostolos G Vagenakis; Athanasios G Papavassiliou
Functional significance of the thyrotropin receptor germline polymorphism D727E.
Biochemical and biophysical research communications 2003;301(4):1051-6.
2003: Mathias Fasshauer; Susan Kralisch; Margit Klier; Ulrike Lossner; Matthias Blüher; Johannes Klein; Ralf Paschke
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 2003;301(4):1045-50.
2003: Thorsten Klemm; S Mittrach-Schorin; Susanne Neumann; TG Gerike; Hans Krankenberg; Gerhard Schuler; Ralf Paschke
No association between the angiotensin-converting-enzyme gene insertion/deletion polymorphism and the occurrence of macroangiopathy in patients with diabetes mellitus type 2.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2003;35(1):43-7.
2003: Wieland Kiess; Antje Böttner; Klemens Raile; Thomas Kapellen; Grit Müller; Angela Galler; Ralf Paschke; Martin Wabitsch
Type 2 diabetes mellitus in children and adolescents: a review from a European perspective.
Hormone research 2003;59 Suppl 1():77-84.
2002: Mathias Fasshauer; Johannes Klein; Ulrike Lossner; Ralf Paschke
Isoproterenol is a positive regulator of the suppressor of cytokine signaling-3 gene expression in 3T3-L1 adipocytes.
The Journal of endocrinology 2002;175(3):727-33.
2002: Markus Eszlinger; Susanne Neumann; Lothar Otto; Ralf Paschke
Thyroglobulin mRNA quantification in the peripheral blood is not a reliable marker for the follow-up of patients with differentiated thyroid cancer.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(5):575-82.
2002: Mathias Fasshauer; Johannes Klein; Ulrike Lossner; Ralf Paschke
Negative regulation of adipose-expressed galectin-12 by isoproterenol, tumor necrosis factor alpha, insulin and dexamethasone.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(4):553-9.
2002: Tobias Lohmann; S Laue; Ute Nietzschmann; Thomas Kapellen; Irina Lehmann; S Schroeder; Ralf Paschke; Wieland Kiess
Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes.
Diabetes 2002;51(8):2474-80.
2002: Henri Wallaschofski; Konstanze Miehle; A Mayer; Ulrich Tuschy; Bettina Hentschel; Ralf Paschke
Prediction of remission or relapse for Graves' hyperthyroidism by the combined determination of stimulating, blocking and binding TSH-receptor antibodies after the withdrawal of antithyroid drug treatment.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(7):383-8.
2002: Hans-Peter Holzapfel; Beate Bergner; Peter Wonerow; Ralf Paschke
Expression of G(alpha)(s) proteins and TSH receptor signalling in hyperfunctioning thyroid nodules with TSH receptor mutations.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(1):109-16.
2002: Matthias Blüher; Thorsten Klemm; TG Gerike; Hans Krankenberg; Gerhard Schuler; Ralf Paschke
Lack of association between peroxisome proliferator-activated receptor-gamma-2 gene variants and the occurrence of coronary heart disease in patients with diabetes mellitus.
European journal of endocrinology / European Federation of Endocrine Societies 2002;146(4):545-51.
2002: Knut Krohn; Ralf Paschke
Somatic mutations in thyroid nodular disease.
Molecular genetics and metabolism 2002;75(3):202-8.
2002: Matthias Blüher; R Unger; Fausi Rassoul; Volker Richter; Ralf Paschke
Relation between glycaemic control, hyperinsulinaemia and plasma concentrations of soluble adhesion molecules in patients with impaired glucose tolerance or Type II diabetes.
Diabetologia 2002;45(2):210-6.
2002: Mathias Fasshauer; Johannes Klein; Susanne Neumann; Markus Eszlinger; Ralf Paschke
Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 2002;290(3):1084-9.
2002: C Lamesch; Susanne Neumann; Roland Pfäffle; Wieland Kiess; Ralf Paschke
Adrenocorticotrope deficiency with clinical evidence for late onset in combined pituitary hormone deficiency caused by a homozygous 301-302delAG mutation of the PROP1 gene.
Pituitary 2002;5(3):163-8.
2002: Henri Wallaschofski; D Müller; P Georgi; Ralf Paschke
Induction of TSH-receptor antibodies in patients with toxic multinodular goitre by radioiodine treatment.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(1):36-9.
2002: Istvan-Tibor Nebel; Matthias Blüher; Ulrike Starcke; Ulrich A Müller; Thomas Haak; Ralf Paschke
Evaluation of a computer based interactive diabetes education program designed to train the estimation of the energy or carbohydrate contents of foods.
Patient education and counseling 2002;46(1):55-9.
2001: Peter Wonerow; Susanne Neumann; Thomas Gudermann; Ralf Paschke
Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action.
Journal of molecular medicine (Berlin, Germany) 2001;79(12):707-21.
2001: Mathias Fasshauer; Johannes Klein; Susanne Neumann; Markus Eszlinger; Ralf Paschke
Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes.
Biochemical and biophysical research communications 2001;288(4):1027-31.
2001: Mathias Fasshauer; Johannes Klein; Susanne Neumann; Markus Eszlinger; Ralf Paschke
Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes.
FEBS letters 2001;507(2):142-6.
2001: Markus Eszlinger; Knut Krohn; Ralf Paschke
Complementary DNA expression array analysis suggests a lower expression of signal transduction proteins and receptors in cold and hot thyroid nodules.
The Journal of clinical endocrinology and metabolism 2001;86(10):4834-42.
2001: Susanne U Miedlich; Peter Lamesch; A Mueller; Ralf Paschke
Frequency of the calcium-sensing receptor variant A986S in patients with primary hyperparathyroidism.
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(4):421-7.
2001: Tobias Lohmann; Christos Trantakis; Markus Biesold; Sascha Prothmann; S Guenzel; Ralf Schober; Ralf Paschke
Minor tumour shrinkage in nonfunctioning pituitary adenomas by long-term treatment with the dopamine agonist cabergoline.
Pituitary 2001;4(3):173-8.
2001: Henri Wallaschofski; C Orda; P Georgi; Konstanze Miehle; Ralf Paschke
Distinction between autoimmune and non-autoimmune hyperthyroidism by determination of TSH-receptor antibodies in patients with the initial diagnosis of toxic multinodular goiter.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(8):504-7.
2001: Knut Krohn; Andreas Reske; Frank Ackermann; A Müller; Ralf Paschke
Ras mutations are rare in solitary cold and toxic thyroid nodules.
Clinical endocrinology 2001;55(2):241-8.
2001: Knut Krohn; Ralf Paschke
Loss of heterozygocity at the thyroid peroxidase gene locus in solitary cold thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2001;11(8):741-7.
2001: Susanne Neumann; Gerd Krause; S Chey; Ralf Paschke
A free carboxylate oxygen in the side chain of position 674 in transmembrane domain 7 is necessary for TSH receptor activation.
Molecular endocrinology (Baltimore, Md.) 2001;15(8):1294-305.
2001: Susanne U Miedlich; Tobias Lohmann; U Schneyer; Peter Lamesch; Ralf Paschke
Familial isolated primary hyperparathyroidism--a multiple endocrine neoplasia type 1 variant?
European journal of endocrinology / European Federation of Endocrine Societies 2001;145(2):155-60.
2001: Henri Wallaschofski; C Orda; Dagmar Führer; Hans-Peter Holzapfel; Knut Krohn; Konstanze Miehle; Susanne Neumann; P Georgi; Ralf Paschke
Distinction between autoimmune and nonautoimmune hyperthyroidism by determination of thyrotropin-receptor antibodies in patients with the scintigraphic diagnosis of disseminated autonomy.
Thyroid : official journal of the American Thyroid Association 2001;11(7):710-1.
2001: Knut Krohn; Ralf Paschke
Clinical review 133: Progress in understanding the etiology of thyroid autonomy.
The Journal of clinical endocrinology and metabolism 2001;86(7):3336-45.
2001: Mathias Fasshauer; Johannes Klein; Susanne Neumann; Markus Eszlinger; Ralf Paschke
Isoproterenol inhibits resistin gene expression through a G(S)-protein-coupled pathway in 3T3-L1 adipocytes.
FEBS letters 2001;500(1-2):60-3.
2001: Susanne Neumann; Knut Krohn; S Chey; Ralf Paschke
Mutations in the mouse TSH receptor equivalent to human constitutively activating TSH receptor mutations also cause constitutive activity.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(5):263-9.
2001: Markus Eszlinger; Knut Krohn; Jürgen Kratzsch; Carsten Voigt; Ralf Paschke
Growth factor expression in cold and hot thyroid nodules.
Thyroid : official journal of the American Thyroid Association 2001;11(2):125-35.
2001: Matthias Blüher; Jürgen Kratzsch; Ralf Paschke
Plasma levels of tumor necrosis factor-alpha, angiotensin II, growth hormone, and IGF-I are not elevated in insulin-resistant obese individuals with impaired glucose tolerance.
Diabetes care 2001;24(2):328-34.
2001: Frank Reichenberger; Hubert Wirtz; Ralf Paschke
Clopidogrel and side effects.
Cardiology 2001;96(1):51-2.
2001: Ralf Paschke; Susanne Neumann
Sodium/iodide symporter mRNA expression in cold thyroid nodules.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2001;109(1):45-6.
2001: Thorsten Klemm; Susanne Neumann; B Trülzsch; F Pistrosch; M Hanefeld; Ralf Paschke
Search for mitochondrial DNA mutation at position 3243 in German patients with a positive family history of maternal diabetes mellitus.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2001;109(5):283-7.
2001: Tobias Lohmann; Jürgen Kratzsch; K Kellner; Helmut Witzigmann; Johann Hauss; Ralf Paschke
Severe hypoglycemia due to insulin autoimmune syndrome with insulin autoantibodies crossreactive to proinsulin.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2001;109(4):245-8.
2001: B Trülzsch; Knut Krohn; Peter Wonerow; S Chey; Hans-Peter Holzapfel; Frank Ackermann; Dagmar Führer; Ralf Paschke
Detection of thyroid-stimulating hormone receptor and Gsalpha mutations: in 75 toxic thyroid nodules by denaturing gradient gel electrophoresis.
Journal of molecular medicine (Berlin, Germany) 2001;78(12):684-91.
2000: Carsten Voigt; Hans-Peter Holzapfel; Ralf Paschke
Expression of beta-arrestins in toxic and cold thyroid nodules.
FEBS letters 2000;486(3):208-12.
2000: Henri Wallaschofski; M Kaczmarek; Konstanze Miehle; Bettina Hentschel; Ralf Paschke
Differences between thyrotropin receptor antibody bioactivity and inhibition of 125I-bovine thyrotropin binding.
Thyroid : official journal of the American Thyroid Association 2000;10(10):897-907.
2000: Matthias Blüher; M Windgassen; Ralf Paschke
Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma.
Diabetes care 2000;23(10):1591-2.
2000: Peter Wonerow; S Chey; Dagmar Führer; Hans-Peter Holzapfel; Ralf Paschke
Functional characterization of five constitutively activating thyrotrophin receptor mutations.
Clinical endocrinology 2000;53(4):461-8.
2000: Knut Krohn; S Wohlgemuth; H Gerber; Ralf Paschke
Hot microscopic areas of iodine-deficient euthyroid goitres contain constitutively activating TSH receptor mutations.
The Journal of pathology 2000;192(1):37-42.
2000: Susanne U Miedlich; Knut Krohn; Peter Lamesch; A Müller; Ralf Paschke
Frequency of somatic MEN1 gene mutations in monoclonal parathyroid tumours of patients with primary hyperparathyroidism.
European journal of endocrinology / European Federation of Endocrine Societies 2000;143(1):47-54.
2000: Thorsten Klemm; Ralf Paschke
[Possible genetic causes for late complications of diabetes mellitus].
Medizinische Klinik (Munich, Germany : 1983) 2000;95(1):31-9.
1999: Matthias Blüher; Knut Krohn; Henri Wallaschofski; L E Braverman; Ralf Paschke
Fas and Fas ligand gene expression in autoimmune thyroiditis in BB/W rats.
European journal of endocrinology / European Federation of Endocrine Societies 1999;141(5):506-11.
1999: Matthias Blüher; Knut Krohn; Henri Wallaschofski; L E Braverman; Ralf Paschke
Cytokine gene expression in autoimmune thyroiditis in BioBreeding/Worcester rats.
Thyroid : official journal of the American Thyroid Association 1999;9(10):1049-55.
1999: Susanne Neumann; Helmut Willgerodt; Frank Ackermann; Andreas Reske; M Jung; A Reis; Ralf Paschke
Linkage of familial euthyroid goiter to the multinodular goiter-1 locus and exclusion of the candidate genes thyroglobulin, thyroperoxidase, and Na+/I- symporter.
The Journal of clinical endocrinology and metabolism 1999;84(10):3750-6.
1999: Dagmar Führer; M Mix; Peter Wonerow; I Richter; Helmut Willgerodt; Ralf Paschke
Variable phenotype associated with Ser505Asn-activating thyrotropin-receptor germline mutation.
Thyroid : official journal of the American Thyroid Association 1999;9(8):757-61.
1999: B Trülzsch; Knut Krohn; Peter Wonerow; Ralf Paschke
DGGE is more sensitive for the detection of somatic point mutations than direct sequencing.
BioTechniques 1999;27(2):266-8.
1999: B Trültzsch; T Nebel; Ralf Paschke
The TSH receptor mutation database.
European journal of endocrinology / European Federation of Endocrine Societies 1999;140(6):VII.
1999: B Trülzsch; T Nebel; Ralf Paschke
The thyrotropin receptor mutation database.
Thyroid : official journal of the American Thyroid Association 1999;9(6):521-2.
1999: I T Nebel; B Trültsch; Ralf Paschke
TSH receptor mutation database.
The Journal of clinical endocrinology and metabolism 1999;84(6):2263.
1999: Dagmar Führer; Ralf Paschke
[Mutations in TSH receptors: pathogenetic significance and clinical relevance].
Deutsche medizinische Wochenschrift (1946) 1999;124(21):662-9.
1999: Henri Wallaschofski; Ralf Paschke
Detection of thyroid stimulating (TSAB)- and thyrotropin stimulation blocking (TSBAB) antibodies with CHO cell lines expressing different TSH-receptor numbers.
Clinical endocrinology 1999;50(3):365-72.
1999: Knut Krohn; Peter Emmrich; N Ott; Ralf Paschke
Increased thyroid epithelial cell proliferation in toxic thyroid nodules.
Thyroid : official journal of the American Thyroid Association 1999;9(3):241-6.
1999: C Weber; Gerhard Scholz; Peter Lamesch; Ralf Paschke
Thyroidectomy in iodine induced thyrotoxic storm.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1999;107(7):468-72.
1999: Thorsten Klemm; Peter Lamesch; Ralf Paschke
Coincidence of hot thyroid nodules and primary hyperparathyroidism.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1999;107(5):295-8.
1999: Frank Ackermann; Knut Krohn; M Windgassen; Michael Buchfelder; Rudolf Fahlbusch; Ralf Paschke
Acromegaly in a family without a mutation in the menin gene.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1999;107(1):93-6.
1998: Dagmar Führer; C Kubisch; U Scheibler; Peter Lamesch; Knut Krohn; Ralf Paschke
The extracellular thyrotropin receptor domain is not a major candidate for mutations in toxic thyroid nodules.
Thyroid : official journal of the American Thyroid Association 1998;8(11):997-1001.
1998: Peter Wonerow; Torsten Schöneberg; G Schultz; Thomas Gudermann; Ralf Paschke
Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation.
The Journal of biological chemistry 1998;273(14):7900-5.
1998: Dagmar Führer; M Mix; Helmut Willgerodt; Hans-Peter Holzapfel; W Von Petrykowski; Peter Wonerow; Ralf Paschke
Autosomal dominant nonautoimmune hyperthyroidism. Clinical features-diagnosis-therapy.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1998;106 Suppl 4():S10-5.
1998: Ralf Paschke
Activation of the cAMP cascade in thyroid autonomy.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1998;106 Suppl 4():S4-5.
1998: Gabriela Aust; Michele Crisp; E Bösenberg; Marian Ludgate; Anthony P Weetman; Ralf Paschke
Transcription of thyroid autoantigens in non-expressing tissues.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1998;106(4):319-23.
1998: Knut Krohn; Dagmar Führer; Hans-Peter Holzapfel; Ralf Paschke
Clonal origin of toxic thyroid nodules with constitutively activating thyrotropin receptor mutations.
The Journal of clinical endocrinology and metabolism 1998;83(1):130-4.
1997: Ralf Paschke; Marian Ludgate
The thyrotropin receptor in thyroid diseases.
The New England journal of medicine 1997;337(23):1675-81.
1997: Dagmar Führer; Peter Wonerow; Helmut Willgerodt; Ralf Paschke
Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism.
The Journal of clinical endocrinology and metabolism 1997;82(12):4234-8.
1997: Hans-Peter Holzapfel; Dagmar Führer; Peter Wonerow; G Weinland; Werner A Scherbaum; Ralf Paschke
Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters.
The Journal of clinical endocrinology and metabolism 1997;82(12):4229-33.
1997: Dagmar Führer; Hans-Peter Holzapfel; Peter Wonerow; Werner A Scherbaum; Ralf Paschke
Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules.
The Journal of clinical endocrinology and metabolism 1997;82(11):3885-91.
1997: Hans-Peter Holzapfel; Peter Wonerow; W von Petrykowski; M Henschen; Werner A Scherbaum; Ralf Paschke
Sporadic congenital hyperthyroidism due to a spontaneous germline mutation in the thyrotropin receptor gene.
The Journal of clinical endocrinology and metabolism 1997;82(11):3879-84.
1996: Dagmar Führer; Hans-Peter Holzapfel; Peter Wonerow; Ralf Paschke
Constitutively activating mutations of the thyrotropin receptor and thyroid disease.
European journal of medical research 1996;1(10):460-4.
1996: Ralf Paschke
Constitutively activating TSH receptor mutations as the cause of toxic thyroid adenoma, multinodular toxic goiter and autosomal dominant non autoimmune hyperthyroidism.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1996;104 Suppl 4():129-32.
1996: K O Schwab; P Söhlemann; M Gerlich; M Broecker; W Petrykowski; Hans-Peter Holzapfel; Ralf Paschke; A Grüters; Michael Derwahl
Mutations of the TSH receptor as cause of congenital hyperthyroidism.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 1996;104 Suppl 4():124-8.
1995: Ralf Paschke; V Geenen
Messenger RNA expression for a TSH receptor variant in the thymus of a two-year-old child.
Journal of molecular medicine (Berlin, Germany) 1995;73(11):577-80.
1995: Werner A Scherbaum; Ralf Paschke
[Significance of thyroid antibodies for diagnosis and follow-up of thyroid diseases].
Der Internist 1995;36(3):303-9.