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Giulio Maria Pasinetti

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Lap Ho; Elsa Janle; Jessica Lobo; Tzu-Ying Chen; Bruce Cooper; Mario G Ferruzzi; Bing Gong; Susan S Percival; James E Simon; Stephen T Talcott; Jun Wang; Qing Li Wu; Giulio Maria Pasinetti
Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.
Wei Zhao; Merina Varghese; Shrishailam Yemul; Kristen Dams-O'Connor; Daniel Freire; Wayne Gordon; Vahram Haroutunian; Lap Ho; Lindsay Knable; Giulio Maria Pasinetti
Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy.
Giulio Maria Pasinetti
Novel role of red wine-derived polyphenols in the prevention of Alzheimer's disease dementia and brain pathology: experimental approaches and clinical implications.

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2013: Lap Ho; Elsa Janle; Jessica Lobo; Tzu-Ying Chen; Bruce Cooper; Mario G Ferruzzi; Bing Gong; Susan S Percival; James E Simon; Stephen T Talcott; Jun Wang; Qing Li Wu; Giulio Maria Pasinetti
Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(2):769-81.
2013: Wei Zhao; Merina Varghese; Shrishailam Yemul; Kristen Dams-O'Connor; Daniel Freire; Wayne Gordon; Vahram Haroutunian; Lap Ho; Lindsay Knable; Giulio Maria Pasinetti
Decreased level of olfactory receptors in blood cells following traumatic brain injury and potential association with tauopathy.
Journal of Alzheimer's disease : JAD 2013;34(2):417-29.
2012: Giulio Maria Pasinetti
Novel role of red wine-derived polyphenols in the prevention of Alzheimer's disease dementia and brain pathology: experimental approaches and clinical implications.
Planta medica 2012;78(15):1614-9.
2012: Ismael Santa-Maria; Jun Wang; Alice Chen; Carmen Diaz-Ruiz; Lap Ho; Hanna Ksiezak-Reding; Giulio Maria Pasinetti
GSPE interferes with tau aggregation in vivo: implication for treating tauopathy.
Neurobiology of aging 2012;33(9):2072-81.
2012: Hanna Ksiezak-Reding; Carmen Diaz-Ruiz; Lap Ho; Ismael Santa-Maria; Jun Wang; Giulio Maria Pasinetti
Ultrastructural alterations of Alzheimer's disease paired helical filaments by grape seed-derived polyphenols.
Neurobiology of aging 2012;33(7):1427-39.
2012: Jun Wang; Chungfen Zhang; Constantine Pavlides; Xianjuan Qian; Daniel Raftery; Vaishali Sharma; James E Simon; David B Teplow; Isabel Arrieta-Cruz; Jack Blount; Alice Cheng; Bruce Cooper; Richard A Dixon; Mario G Ferruzzi; Bing Gong; G A Nagana Gowda; Lap Ho; Elsa Janle; Jessica Lobo; Kenjiro Ono; Yong Pan; Giulio Maria Pasinetti
Brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(15):5144-50.
2012: Wei Zhao; Merina Varghese; Prashant Vempati; Jun Wang; Amanda Bilski; Alice Cheng; Anastasiya Dzhun; Irene Faravelli; Dale Lange; Giulio Maria Pasinetti
Caprylic triglyceride as a novel therapeutic approach to effectively improve the performance and attenuate the symptoms due to the motor neuron loss in ALS disease.
PloS one 2012;7(11):e49191.
2012: Lap Ho; Pavel Katsel; Lindsay Knable; Shrishailam Yemul; Rudy Zhao; Vahram Haroutunian; Giulio Maria Pasinetti
Insulin receptor expression and activity in the brains of nondiabetic sporadic Alzheimer's disease cases.
International journal of Alzheimer's disease 2012;2012():321280.
2012: Lap Ho; Kristen Dams-O'Connor; Wayne Gordon; Vahram Haroutunian; Elaine R Peskind; Cheuk Y Tang; Shrishailam Yemul; Wei Zhao; Giulio Maria Pasinetti
Elevated plasma MCP-1 concentration following traumatic brain injury as a potential "predisposition" factor associated with an increased risk for subsequent development of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2012;31(2):301-13.
2011: Jun Wang; Wei Zhao; Constantine Pavlides; Xianjuan Qian; Rakesh Subnani; David B Teplow; Isabel Arrieta-Cruz; Dara L Dickstein; Mario Ferruzzi; Lap Ho; Patrick R Hof; Ashley Lamparello; Kenjiro Ono; Giulio Maria Pasinetti
Carvedilol as a potential novel agent for the treatment of Alzheimer's disease.
Neurobiology of aging 2011;32(12):2321.e1-12.
2011: Giulio Maria Pasinetti; Jun Wang; Mario Ferruzzi; Paul Gregor; Lindsay Alexis Knable; Philippe Marambaud; Lap Ho
Neuroprotective and metabolic effects of resveratrol: therapeutic implications for Huntington's disease and other neurodegenerative disorders.
Experimental neurology 2011;232(1):1-6.
2010: Giulio Maria Pasinetti; Hayley Fivecoat; Lap Ho
Personalized medicine in traumatic brain injury.
The Psychiatric clinics of North America 2010;33(4):905-13.
2010: Giulio Maria Pasinetti; Hanna Ksiezak-Reding; Ismael Santa-Maria; Jun Wang; Lap Ho
Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies.
Journal of neurochemistry 2010;114(6):1557-68.
2010: Lap Ho; Giulio Maria Pasinetti
Polyphenolic compounds for treating neurodegenerative disorders involving protein misfolding.
Expert review of proteomics 2010;7(4):579-89.
2010: Jun Wang; Hayley Fivecoat; Lap Ho; Yong Pan; Emi Ling; Giulio Maria Pasinetti
The role of Sirt1: at the crossroad between promotion of longevity and protection against Alzheimer's disease neuropathology.
Biochimica et biophysica acta 2010;1804(8):1690-4.
2010: Jun Wang; Ismael Santa-Maria; Lap Ho; Hanna Ksiezak-Reding; Kenjiro Ono; David B Teplow; Giulio Maria Pasinetti
Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2010;22(2):653-61.
2010: Isabel Arrieta-Cruz; Jun Wang; Constantine Pavlides; Giulio Maria Pasinetti
Carvedilol reestablishes long-term potentiation in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2010;21(2):649-54.
2010: Lap Ho; Hayley Fivecoat; Jun Wang; Giulio Maria Pasinetti
Alzheimer's disease biomarker discovery in symptomatic and asymptomatic patients: experimental approaches and future clinical applications.
Experimental gerontology 2010;45(1):15-22.
2009: Weiping Qin; Vahram Haroutunian; Pavel Katsel; Christopher P Cardozo; Lap Ho; Joseph Buxbaum; Giulio Maria Pasinetti
PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia.
Archives of neurology 2009;66(3):352-61.
2009: C Díaz-Ruiz; Jun Wang; Hanna Ksiezak-Reding; Lap Ho; Xianjuan Qian; Nelson Humala; S Thomas; P Martínez-Martín; Giulio Maria Pasinetti
Role of Hypertension in Aggravating Abeta Neuropathology of AD Type and Tau-Mediated Motor Impairment.
Cardiovascular psychiatry and neurology 2009;2009():107286.
2009: Mario G Ferruzzi; Jessica K Lobo; Elsa Janle; Bruce Cooper; James E Simon; Qing-Li Wu; Cara Welch; Lap Ho; Connie Weaver; Giulio Maria Pasinetti
Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;18(1):113-24.
2009: Lap Ho; Shrishailam Yemul; Jun Wang; Giulio Maria Pasinetti
Grape seed polyphenolic extract as a potential novel therapeutic agent in tauopathies.
Journal of Alzheimer's disease : JAD 2009;16(2):433-9.
2009: Marialaura Amadio; Alessia Pascale; Jun Wang; Lap Ho; Alessandro Quattrone; Sam Gandy; Vahram Haroutunian; Marco Racchi; Giulio Maria Pasinetti
nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing.
Journal of Alzheimer's disease : JAD 2009;16(2):409-19.
2009: Weiping Qin; Lap Ho; Jun Wang; Elaine Peskind; Giulio Maria Pasinetti
S100A7, a novel Alzheimer's disease biomarker with non-amyloidogenic alpha-secretase activity acts via selective promotion of ADAM-10.
PloS one 2009;4(1):e4183.
2009: Lap Ho; Ling Hong Chen; Jun Wang; Wei Zhao; Stephen T Talcott; Kenjiro Ono; David B Teplow; Nelson Humala; Alice Cheng; Susan S Percival; Mario Ferruzzi; Elsa Janle; Dara L Dickstein; Giulio Maria Pasinetti
Heterogeneity in red wine polyphenolic contents differentially influences Alzheimer's disease-type neuropathology and cognitive deterioration.
Journal of Alzheimer's disease : JAD 2009;16(1):59-72.
2009: Wei Zhao; Jun Wang; Lap Ho; Kenjiro Ono; David B Teplow; Giulio Maria Pasinetti
Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization.
Journal of Alzheimer's disease : JAD 2009;16(1):49-57.
2008: Weiping Qin; Wei Zhao; Lap Ho; Jun Wang; Kenneth Walsh; Sam Gandy; Giulio Maria Pasinetti
Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration.
Annals of the New York Academy of Sciences 2008;1147():335-47.
2008: Kenjiro Ono; Margaret M Condron; Lap Ho; Jun Wang; Wei Zhao; Giulio Maria Pasinetti; David B Teplow
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.
The Journal of biological chemistry 2008;283(47):32176-87.
2008: Giulio Maria Pasinetti; Jacqueline A Eberstein
Metabolic syndrome and the role of dietary lifestyles in Alzheimer's disease.
Journal of neurochemistry 2008;106(4):1503-14.
2008: Jun Wang; Lap Ho; Wei Zhao; Kenjiro Ono; Clark Rosensweig; Linghong Chen; Nelson Humala; David B Teplow; Giulio Maria Pasinetti
Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(25):6388-92.
2008: Naresh Sharma; Sunil Thomas; Lap Ho; Dillenia C Reyes; Paola Sacerdote; Mauro Bianchi; Giulio Maria Pasinetti
Immunomodulation with glatiramer acetate prevents long-term inflammatory pain.
The International journal of neuroscience 2008;118(3):433-53.
2008: Rudy Zhao; Dale J Lange; Lap Ho; Sara Anna Bonini; Belinda Shao; Stephen R Salton; Sunil Thomas; Giulio Maria Pasinetti
Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis.
International journal of medical sciences 2008;5(2):92-9.
2008: Piali Mukherjee; Sunil Thomas; Giulio Maria Pasinetti
Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo.
Journal of neuroinflammation 2008;5():5.
2007: Zhongmin Xiang; Sunil Thomas; Giulio Maria Pasinetti
Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment.
Current neurovascular research 2007;4(4):274-9.
2007: Jun Wang; Lap Ho; Linghong Chen; Rudy Zhao; Wei Zhao; Xianjuan Qian; Nelson Humala; Ilana Seror; Sadie Bartholomew; Clive Rosendorff; Giulio Maria Pasinetti
Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease.
The Journal of clinical investigation 2007;117(11):3393-402.
2007: Rudy Zhao; Zhongmin Xiang; Vahram Haroutunian; Joseph Buxbaum; Breton Stetka; Giulio Maria Pasinetti
Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease.
Neurobiology of aging 2007;28(6):824-30.
2007: Giulio Maria Pasinetti; Rudy Zhao; Weiping Qin; Lap Ho; Yemul Shrishailam; Donal MacGrogan; Wendy Ressmann; Nelson Humala; Xunxian Liu; Carmen Romero; Breton Stetka; Linghong Chen; Hanna Ksiezak-Reding; Jun Wang
Caloric intake and Alzheimer's disease. Experimental approaches and therapeutic implications.
Interdisciplinary topics in gerontology 2007;35():159-75.
2006: Weiping Qin; Mark E Chachich; Mark Lane; George Roth; Mark Bryant; Rafael de Cabo; Mary Ann Ottinger; Julie A Mattison; Donald Ingram; Sam Gandy; Giulio Maria Pasinetti
Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).
Journal of Alzheimer's disease : JAD 2006;10(4):417-22.
2006: Makio Takahashi; Hirotake Uchikado; Domenico Caprotti; Karen M Weidenheim; dennis dickson; Hanna Ksiezak-Reding; Giulio Maria Pasinetti
Identification of G-protein coupled receptor kinase 2 in paired helical filaments and neurofibrillary tangles.
Journal of neuropathology and experimental neurology 2006;65(12):1157-69.
2006: Jun Wang; Lap Ho; Rudy Zhao; Ilana Seror; Nelson Humala; Dara L Dickstein; Meenakshisundaram Thiyagarajan; Susan S Percival; Stephen T Talcott; Giulio Maria Pasinetti
Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(13):2313-20.
2006: Weiping Qin; Tianle Yang; Lap Ho; Rudy Zhao; Jun Wang; Linghong Chen; Wei Zhao; Meenakshisundaram Thiyagarajan; Donal MacGrogan; Joseph T Rodgers; Pere Puigserver; Junichi Sadoshima; Haiteng Deng; Steve Pedrini; Sam Gandy; Anthony A Sauve; Giulio Maria Pasinetti
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.
The Journal of biological chemistry 2006;281(31):21745-54.
2006: Rudy Zhao; Hanna Ksiezak-Reding; Silvana Riggio; Vahram Haroutunian; Giulio Maria Pasinetti
Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction.
Schizophrenia research 2006;84(1):1-14.
2006: Giulio Maria Pasinetti; L H Ungar; D J Lange; Shrishailam Yemul; H Deng; X Yuan; Robert H Brown; Merit E Cudkowicz; Kristyn Newhall; Elaine Peskind; S Marcus; Lap Ho
Identification of potential CSF biomarkers in ALS.
Neurology 2006;66(8):1218-22.
2006: Weiping Qin; Y Peng; Hanna Ksiezak-Reding; Lap Ho; Breton Stetka; E Lovati; Giulio Maria Pasinetti
Inhibition of cyclooxygenase as potential novel therapeutic strategy in N141I presenilin-2 familial Alzheimer's disease.
Molecular psychiatry 2006;11(2):172-81.
2006: Rudy Zhao; Dale J Lange; Andrei Voustianiouk; Donal MacGrogan; Lap Ho; Jason Suh; Nelson Humala; Meenakshisundaram Thiyagarajan; Jun Wang; Giulio Maria Pasinetti
A ketogenic diet as a potential novel therapeutic intervention in amyotrophic lateral sclerosis.
BMC neuroscience 2006;7():29.
2006: Lap Ho; Weiping Qin; Breton Stetka; Giulio Maria Pasinetti
Is there a future for cyclo-oxygenase inhibitors in Alzheimer's disease?
CNS drugs 2006;20(2):85-98.
2006: Zhongmin Xiang; Vahram Haroutunian; Lap Ho; Dushyant P Purohit; Giulio Maria Pasinetti
Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia.
Disease markers 2006;22(1-2):95-102.
2005: Rudy Zhao; Lap Ho; Jun Wang; Weiping Qin; Eugene D Festa; Charles V Mobbs; Patrick R Hof; Anne B Rocher; Sandra K Masur; Vahram Haroutunian; Giulio Maria Pasinetti
Connective tissue growth factor (CTGF) expression in the brain is a downstream effector of insulin resistance- associated promotion of Alzheimer's disease beta-amyloid neuropathology.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2081-2.
2005: Rudy Zhao; Hanna Ksiezak-Reding; Jun Wang; Giulio Maria Pasinetti
Expression of tau reduces secretion of Abeta without altering the amyloid precursor protein content in CHOsw cells.
FEBS letters 2005;579(10):2119-24.
2005: Lap Ho; Naresh Sharma; Laurel Blackman; Eugene Festa; Guru Reddy; Giulio Maria Pasinetti
From proteomics to biomarker discovery in Alzheimer's disease.
Brain research. Brain research reviews 2005;48(2):360-9.
2005: Jun Wang; Lap Ho; Weiping Qin; Anne B Rocher; Ilana Seror; Nelson Humala; Kruti Maniar; Georgia Dolios; Rong Wang; Patrick R Hof; Giulio Maria Pasinetti
Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(6):659-61.
2004: Lap Ho; Weiping Qin; Patrick N Pompl; Zhongmin Xiang; Jun Wang; Rudy Zhao; Yuanzhen Peng; Gina Cambareri; Anne B Rocher; Charles V Mobbs; Patrick R Hof; Giulio Maria Pasinetti
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(7):902-4.
2004: Hui Zhao; Meena Jhanwar-Uniyal; Prasun K Datta; Shrishailam Yemul; Lap Ho; Gregory Khitrov; Ilya Kupershmidt; Giulio Maria Pasinetti; Tarun Ray; Raghbir S Athwal; Mohanrao P Achary
Expression profile of genes associated with antimetastatic gene: nm23-mediated metastasis inhibition in breast carcinoma cells.
International journal of cancer. Journal international du cancer 2004;109(1):65-70.
2004: H Kyoung Pyo; E Lovati; Giulio Maria Pasinetti; Hanna Ksiezak-Reding
Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: the role of AKT.
Neuroscience 2004;127(3):649-58.
2003: Weiping Qin; Lap Ho; Patrick N Pompl; Yuanzhen Peng; Rudy Zhao; Zhongmin Xiang; Nikolaos K Robakis; Junichi Shioi; Jason Suh; Giulio Maria Pasinetti
Cyclooxygenase (COX)-2 and COX-1 potentiate beta-amyloid peptide generation through mechanisms that involve gamma-secretase activity.
The Journal of biological chemistry 2003;278(51):50970-7.
2003: Hanna Ksiezak-Reding; Han Kyoung Pyo; Boris Feinstein; Giulio Maria Pasinetti
Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro.
Biochimica et biophysica acta 2003;1639(3):159-68.
2003: Tooru M Mizuno; Kevin A Kelley; Giulio Maria Pasinetti; James Roberts; Charles V Mobbs
Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice.
Diabetes 2003;52(11):2675-83.
2003: Rudy Zhao; Lap Ho; J Suh; Weiping Qin; H Pyo; Patrick N Pompl; Hanna Ksiezak-Reding; Giulio Maria Pasinetti
A role of P301L tau mutant in anti-apoptotic gene expression, cell cycle and apoptosis.
Molecular and cellular neurosciences 2003;24(2):367-79.
2003: Patrick N Pompl; Lap Ho; M Bianchi; T McManus; Weiping Qin; Giulio Maria Pasinetti
A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(6):725-7.
2003: Patrick N Pompl; Shrishailam Yemul; Zhongmin Xiang; Lap Ho; Vahram Haroutunian; Dushyant P Purohit; Richard C Mohs; Giulio Maria Pasinetti
Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease.
Archives of neurology 2003;60(3):369-76.
2003: C Gineste; Lap Ho; Patrick N Pompl; M Bianchi; Giulio Maria Pasinetti
High-throughput proteomics and protein biomarker discovery in an experimental model of inflammatory hyperalgesia: effects of nimesulide.
Drugs 2003;63 Suppl 1():23-9.
2002: Giulio Maria Pasinetti; Patrick N Pompl
Cyclo-oxygenase inhibitors and Alzheimer's: are we well ADAPTed?
Lancet neurology 2002;1(7):403-4.
2002: Giulio Maria Pasinetti
From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in beta-amyloidosis and clinical dementia.
Journal of Alzheimer's disease : JAD 2002;4(5):435-45.
2002: Giulio Maria Pasinetti
Cyclooxygenase as a target for the antiamyloidogenic activities of nonsteroidal anti-inflammatory drugs in Alzheimer's disease.
Neuro-Signals 2002;11(5):293-7.
2002: Giulio Maria Pasinetti; Lap Ho; Patrick N Pompl
Amyloid immunization in Alzheimer's disease: do we promote amyloid scavenging at the cost of inflammatory degeneration?
Neurobiology of aging 2002;23(5):665-6.
2002: P Mukherjee; Giulio Maria Pasinetti
Altered gene expression during nimesulide-mediated inhibition of apoptotic death in human chondrocytes.
International journal of clinical practice. Supplement 2002;(128):20-3.
2002: D Allan Butterfield; Sue Griffin; Gerald Münch; Giulio Maria Pasinetti
Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists.
Journal of Alzheimer's disease : JAD 2002;4(3):193-201.
2002: Paul H Wen; Xiang Shao; Zhiping Shao; Patrick R Hof; Thomas Wisniewski; Kevin Kelley; Victor L Friedrich; Lap Ho; Giulio Maria Pasinetti; Junichi Shioi; Nikolaos K Robakis; Gregory A Elder
Overexpression of wild type but not an FAD mutant presenilin-1 promotes neurogenesis in the hippocampus of adult mice.
Neurobiology of disease 2002;10(1):8-19.
2002: Mana Mirjany; Lap Ho; Giulio Maria Pasinetti
Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity.
The Journal of pharmacology and experimental therapeutics 2002;301(2):494-500.
2002: Zhongmin Xiang; Lap Ho; Jennifer Valdellon; David R Borchelt; Kevin Kelley; Lauren Spielman; Paul S Aisen; Giulio Maria Pasinetti
Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology.
Neurobiology of aging 2002;23(3):327-34.
2002: Paul S Aisen; J Schmeidler; Giulio Maria Pasinetti
Randomized pilot study of nimesulide treatment in Alzheimer's disease.
Neurology 2002;58(7):1050-4.
2002: Lauren Spielman; David Winger; Lap Ho; Paul S Aisen; Esther Shohami; Giulio Maria Pasinetti
Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2.
Acta neuropathologica 2002;103(2):157-62.
2002: Zhongmin Xiang; Lap Ho; Shrishailam Yemul; Rudy Zhao; Wein Qing; Patrick N Pompl; Kevin Kelley; Anju Dang; Weiping Qing; David B Teplow; Giulio Maria Pasinetti
Cyclooxygenase-2 promotes amyloid plaque deposition in a mouse model of Alzheimer's disease neuropathology.
Gene expression 2002;10(5-6):271-8.
2001: Giulio Maria Pasinetti
Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia.
Journal of neuroscience research 2001;65(6):471-6.
2001: Lap Ho; Zhongmin Xiang; P Mukherjee; W Zhang; N De Jesus; M Mirjany; Shrishailam Yemul; Giulio Maria Pasinetti
Gene expression profiling of the tau mutant (P301L) transgenic mouse brain.
Neuroscience letters 2001;310(1):1-4.
2001: P Mukherjee; Giulio Maria Pasinetti
Complement anaphylatoxin C5a neuroprotects through mitogen-activated protein kinase-dependent inhibition of caspase 3.
Journal of neurochemistry 2001;77(1):43-9.
2001: Lap Ho; Dushyant P Purohit; Vahram Haroutunian; JD Luterman; F Willis; J Naslund; Joseph Buxbaum; Richard C Mohs; Paul S Aisen; Giulio Maria Pasinetti
Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease.
Archives of neurology 2001;58(3):487-92.
2001: Lap Ho; Y Guo; Lauren Spielman; O Petrescu; Vahram Haroutunian; Dushyant P Purohit; A Czernik; Shrishailam Yemul; Paul S Aisen; Richard C Mohs; Giulio Maria Pasinetti
Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique.
Neuroscience letters 2001;298(3):191-4.
2001: Giulio Maria Pasinetti; L Ho
From cDNA microarrays to high-throughput proteomics. Implications in the search for preventive initiatives to slow the clinical progression of Alzheimer's disease dementia.
Restorative neurology and neuroscience 2001;18(2-3):137-42.
2001: P Mukherjee; C Rachita; Paul S Aisen; Giulio Maria Pasinetti
Non-steroidal anti-inflammatory drugs protect against chondrocyte apoptotic death.
Clinical and experimental rheumatology 2001;19(1 Suppl 22):S7-11.
2000: M Hull; Giulio Maria Pasinetti; Paul S Aisen
Elevated plasma neopterin levels in Alzheimer disease.
Alzheimer disease and associated disorders 2000;14(4):228-30.
2000: JD Luterman; Vahram Haroutunian; Shrishailam Yemul; Lap Ho; Dushyant P Purohit; Paul S Aisen; Richard C Mohs; Giulio Maria Pasinetti
Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia.
Archives of neurology 2000;57(8):1153-60.
2000: Lap Ho; JD Luterman; Paul S Aisen; Giulio Maria Pasinetti; Thomas J Montine; J D Morrow
Elevated CSF prostaglandin E2 levels in patients with probable AD.
Neurology 2000;55(2):323.
2000: P Mukherjee; Giulio Maria Pasinetti
The role of complement anaphylatoxin C5a in neurodegeneration: implications in Alzheimer's disease.
Journal of neuroimmunology 2000;105(2):124-30.
2000: Haruhiko Akiyama; Steven W Barger; S Barnum; B Bradt; J Bauer; Gregory M. Cole; N R Cooper; Piet Eikelenboom; M Emmerling; B L Fiebich; Caleb E Finch; S Frautschy; W S Griffin; Harald Hampel; M Hull; Gary Landreth; Lih-Fen Lue; R Mrak; I R Mackenzie; Patrick L McGeer; M K O'Banion; Joel S. Pachter; Giulio Maria Pasinetti; C Plata-Salaman; Joseph Rogers; R Rydel; Yong Shen; W Streit; R Strohmeyer; I Tooyoma; F L Van Muiswinkel; R Veerhuis; Douglas G. Walker; S Webster; B Wegrzyniak; Gary L Wenk; Tony Wyss-Coray
Inflammation and Alzheimer's disease.
Neurobiology of aging 2000;21(3):383-421.
1999: Fiorenzo Battaini; Alessia Pascale; Laura Lucchi; Giulio Maria Pasinetti; Stefano Govoni
Protein kinase C anchoring deficit in postmortem brains of Alzheimer's disease patients.
Experimental neurology 1999;159(2):559-64.
1999: Kevin A Kelley; Lap Ho; David Winger; J Freire-Moar; C B Borelli; Paul S Aisen; Giulio Maria Pasinetti
Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2.
The American journal of pathology 1999;155(3):995-1004.
1999: Lap Ho; C Pieroni; David Winger; Dushyant P Purohit; Paul S Aisen; Giulio Maria Pasinetti
Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease.
Journal of neuroscience research 1999;57(3):295-303.
1999: H Osaka; P Mukherjee; Paul S Aisen; Giulio Maria Pasinetti
Complement-derived anaphylatoxin C5a protects against glutamate-mediated neurotoxicity.
Journal of cellular biochemistry 1999;73(3):303-11.
1999: J T Chun; L Wang; Giulio Maria Pasinetti; Caleb E Finch; Berislav V Zlokovic
Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus.
Experimental neurology 1999;157(1):194-201.
1999: Giulio Maria Pasinetti; M Hassler; D Stone; Caleb E Finch
Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions.
Synapse (New York, N.Y.) 1999;31(4):278-84.
1999: H Osaka; A McGinty; U E Höepken; B Lu; C Gerard; Giulio Maria Pasinetti
Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration.
Neuroscience 1999;88(4):1073-82.
1998: Paul S Aisen; Alyssa C Luddy; Martina Durner; J F Reinhard; Giulio Maria Pasinetti
HLA-DR4 influences glial activity in Alzheimer's disease hippocampus.
Journal of the neurological sciences 1998;161(1):66-9.
1998: Giulio Maria Pasinetti; Paul S Aisen
Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain.
Neuroscience 1998;87(2):319-24.
1998: Giulio Maria Pasinetti
Cyclooxygenase and inflammation in Alzheimer's disease: experimental approaches and clinical interventions.
Journal of neuroscience research 1998;54(1):1-6.
1998: Lap Ho; H Osaka; Paul S Aisen; Giulio Maria Pasinetti
Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death.
Journal of neuroimmunology 1998;89(1-2):142-9.
1998: Paul S Aisen; Giulio Maria Pasinetti
Glucocorticoids in Alzheimer's disease. The story so far.
Drugs & aging 1998;12(1):1-6.
1997: Georges Tocco; W Musleh; SH Sakhi; Steven S. Schreiber; Michel Baudry; Giulio Maria Pasinetti
Complement and glutamate neurotoxicity. Genotypic influences of C5 in a mouse model of hippocampal neurodegeneration.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1997;31(3):289-300.
1997: Georges Tocco; J Freire-Moar; Steven S. Schreiber; SH Sakhi; Paul S Aisen; Giulio Maria Pasinetti
Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease.
Experimental neurology 1997;144(2):339-49.
1996: Giulio Maria Pasinetti
Inflammatory mechanisms in neurodegeneration and Alzheimer's disease: the role of the complement system.
Neurobiology of aging 1996;17(5):707-16.
1996: Maddalena Fratelli; G Galli; M Minto; Giulio Maria Pasinetti
Role of clusterin in cell adhesion during early phases of programmed cell death in P19 embryonic carcinoma cells.
Biochimica et biophysica acta 1996;1311(2):71-6.
1996: Giulio Maria Pasinetti; Georges Tocco; S Sakhi; W Musleh; M G DeSimoni; P Mascarucci; Steven S. Schreiber; Michel Baudry; Caleb E Finch
Hereditary deficiencies in complement C5 are associated with intensified neurodegenerative responses that implicate new roles for the C-system in neuronal and astrocytic functions.
Neurobiology of disease 1996;3(3):197-204.
1995: T Oda; PA Wals; H H Osterburg; S A Johnson; Giulio Maria Pasinetti; Todd E Morgan; Irina Rozovsky; W B Stine; Seth Snyder; Thomas F Holzman
Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress.
Experimental neurology 1995;136(1):22-31.
1995: P Bertrand; Judes Poirier; T Oda; Caleb E Finch; Giulio Maria Pasinetti
Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.
Brain research. Molecular brain research 1995;33(1):174-8.
1995: Todd E Morgan; Nicholas J Laping; Irina Rozovsky; T Oda; T H Hogan; Caleb E Finch; Giulio Maria Pasinetti
Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions.
Journal of neuroimmunology 1995;58(1):101-10.
1994: T Oda; Giulio Maria Pasinetti; H H Osterburg; C Anderson; S A Johnson; Caleb E Finch
Purification and characterization of brain clusterin.
Biochemical and biophysical research communications 1994;204(3):1131-6.
1994: Irina Rozovsky; Todd E Morgan; D A Willoughby; M M Dugichi-Djordjevich; Giulio Maria Pasinetti; S A Johnson; Caleb E Finch
Selective expression of clusterin (SGP-2) and complement C1qB and C4 during responses to neurotoxins in vivo and in vitro.
Neuroscience 1994;62(3):741-58.
1994: Heng-Wei Cheng; T Jiang; S A Brown; Giulio Maria Pasinetti; Caleb E Finch; Tom McNeill
Response of striatal astrocytes to neuronal deafferentation: an immunocytochemical and ultrastructural study.
Neuroscience 1994;62(2):425-39.
1994: S A Johnson; Giulio Maria Pasinetti; Caleb E Finch
Expression of complement C1qB and C4 mRNAs during rat brain development.
Brain research. Developmental brain research 1994;80(1-2):163-74.
1994: Giulio Maria Pasinetti; S A Johnson; T Oda; Irina Rozovsky; Caleb E Finch
Clusterin (SGP-2): a multifunctional glycoprotein with regional expression in astrocytes and neurons of the adult rat brain.
The Journal of comparative neurology 1994;339(3):387-400.
1993: Caleb E Finch; Nicholas J Laping; Todd E Morgan; N R Nichols; Giulio Maria Pasinetti
TGF-beta 1 is an organizer of responses to neurodegeneration.
Journal of cellular biochemistry 1993;53(4):314-22.
1993: P A Lapchak; D M Araujo; Giulio Maria Pasinetti; F Hefti
Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis.
Brain research 1993;613(2):239-46.
1993: Giulio Maria Pasinetti; N R Nichols; Georges Tocco; Todd E Morgan; Nicholas J Laping; Caleb E Finch
Transforming growth factor beta 1 and fibronectin messenger RNA in rat brain: responses to injury and cell-type localization.
Neuroscience 1993;54(4):893-907.
1993: Todd E Morgan; N R Nichols; Giulio Maria Pasinetti; Caleb E Finch
TGF-beta 1 mRNA increases in macrophage/microglial cells of the hippocampus in response to deafferentation and kainic acid-induced neurodegeneration.
Experimental neurology 1993;120(2):291-301.
1993: Giulio Maria Pasinetti; Heng-Wei Cheng; Dave Morgan; M Lampert-Etchells; Tom McNeill; Caleb E Finch
Astrocytic messenger RNA responses to striatal deafferentation in male rat.
Neuroscience 1993;53(1):199-211.
1992: D A Willoughby; S A Johnson; Giulio Maria Pasinetti; Georges Tocco; I Najm; Michel Baudry; Caleb E Finch
Amyloid precursor protein mRNA encoding the Kunitz protease inhibitor domain is increased by kainic acid-induced seizures in rat hippocampus.
Experimental neurology 1992;118(3):332-9.
1992: Giulio Maria Pasinetti; S A Johnson; Irina Rozovsky; M Lampert-Etchells; Dave Morgan; Marcia N Gordon; Todd E Morgan; D Willoughby; Caleb E Finch
Complement C1qB and C4 mRNAs responses to lesioning in rat brain.
Experimental neurology 1992;118(2):117-25.
1992: S A Johnson; M Lampert-Etchells; Giulio Maria Pasinetti; Irina Rozovsky; Caleb E Finch
Complement mRNA in the mammalian brain: responses to Alzheimer's disease and experimental brain lesioning.
Neurobiology of aging 1992;13(6):641-8.
1992: A Popa-Wagner; J R Day; D Platt; Giulio Maria Pasinetti
Decortication and striatal mRNA: increases of mRNA for fibronectin, but not of NCAM or alpha-1 tubulin.
Neuroreport 1992;3(10):853-6.
1992: M M Dugich-Djordjevic; Georges Tocco; D A Willoughby; I Najm; Giulio Maria Pasinetti; Richard F Thompson; Michel Baudry; P A Lapchak; F Hefti
BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity.
Neuron 1992;8(6):1127-38.
1992: Caleb E Finch; Steven G Kohama; Giulio Maria Pasinetti
Ovarian steroid and neurotoxin models of brain aging in rodents.
Annals of the New York Academy of Sciences 1992;648():119-24.
1992: Giulio Maria Pasinetti; H H Osterburg; A B Kelly; Steven G Kohama; Dave Morgan; J F Reinhard; R H Stellwagen; Caleb E Finch
Slow changes of tyrosine hydroxylase gene expression in dopaminergic brain neurons after neurotoxin lesioning: a model for neuron aging.
Brain research. Molecular brain research 1992;13(1-2):63-73.
1992: M M Dugich-Djordjevic; Georges Tocco; P A Lapchak; Giulio Maria Pasinetti; I Najm; Michel Baudry; F Hefti
Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid.
Neuroscience 1992;47(2):303-15.
1991: Giulio Maria Pasinetti; Steven G Kohama; J F Reinhard; Heng-Wei Cheng; Tom McNeill; Caleb E Finch
Striatal responses to decortication. I. Dopaminergic and astrocytic activities.
Brain research 1991;567(2):253-9.
1991: Giulio Maria Pasinetti; Caleb E Finch
Sulfated glycoprotein-2 (SGP-2) mRNA is expressed in rat striatal astrocytes following ibotenic acid lesions.
Neuroscience letters 1991;130(1):1-4.
1991: K D Beck; B Knusel; Giulio Maria Pasinetti; P P Michel; H Zawadzka; M Goldstein; F Hefti
Tyrosine hydroxylase mRNA expression by dopaminergic neurons in culture: effect of 1-methyl-4-phenylpyridinium treatment.
Journal of neurochemistry 1991;57(2):527-32.
1991: Giulio Maria Pasinetti; Dave Morgan; Caleb E Finch
Disappearance of GAD-mRNA and tyrosine hydroxylase in substantia nigra following striatal ibotenic acid lesions: evidence for transneuronal regression.
Experimental neurology 1991;112(2):131-9.
1991: Giulio Maria Pasinetti; Heng-Wei Cheng; J F Reinhard; Caleb E Finch; Tom McNeill
Molecular and morphological correlates following neuronal deafferentation: a cortico-striatal model.
Advances in experimental medicine and biology 1991;296():249-55.
1990: J R Day; Nicholas J Laping; Tom McNeill; Steven S. Schreiber; Giulio Maria Pasinetti; Caleb E Finch
Castration enhances expression of glial fibrillary acidic protein and sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat.
Molecular endocrinology (Baltimore, Md.) 1990;4(12):1995-2002.
1990: Giulio Maria Pasinetti; Dave Morgan; S A Johnson; S L Millar; Caleb E Finch
Tyrosine hydroxylase mRNA concentration in midbrain dopaminergic neurons is differentially regulated by reserpine.
Journal of neurochemistry 1990;55(5):1793-9.
1989: Giulio Maria Pasinetti; Dave Morgan; S A Johnson; S P Lerner; M A Myers; J Poirier; Caleb E Finch
Combined in situ hybridization and immunocytochemistry in the assay of pharmacological effects on tyrosine hydroxylase mRNA concentration.
Pharmacological research : the official journal of the Italian Pharmacological Society 1989;21(3):299-311.
1989: Giulio Maria Pasinetti; S P Lerner; S A Johnson; Dave Morgan; N A Telford; Caleb E Finch
Chronic lesions differentially decrease tyrosine hydroxylase messenger RNA in dopaminergic neurons of the substantia nigra.
Brain research. Molecular brain research 1989;5(3):203-9.
1988: S A Johnson; Giulio Maria Pasinetti; Patrick May; P A Ponte; B Cordell; Caleb E Finch
Selective reduction of mRNA for the beta-amyloid precursor protein that lacks a Kunitz-type protease inhibitor motif in cortex from Alzheimer brains.
Experimental neurology 1988;102(2):264-8.
1987: Stefano Govoni; Giulio Maria Pasinetti; A Bianchi; M Gadola; M Trabucchi
Heavy drinking decreases plasma met-enkephalin concentrations.
Alcohol and drug research 1987;7(2):93-8.
1986: M S Magnoni; Lodovico Frattola; Giulio Maria Pasinetti; Stefano Govoni; Fiorenzo Battaini; Marco Trabucchi
Time-related asymmetric changes of brain microvessel beta-adrenergic receptors in the two hemispheres after carotid occlusion.
Stroke; a journal of cerebral circulation 1986;17(5):966-9.
1986: M S Magnoni; H Kobayashi; Stefano Govoni; Fiorenzo Battaini; Giulio Maria Pasinetti; M Trabucchi
Partial reversal of asymmetry in microvessel neurochemical changes after ischemia by corpus callosum section.
Circulation 1986;73(4):784-8.
1986: C Missale; Stefano Govoni; Giulio Maria Pasinetti; C Assini; P F Spano; F Battaini; Marco Trabucchi
Age-dependent changes in the mechanisms regulating dopamine uptake in the central nervous system.
Journal of gerontology 1986;41(2):136-9.
1986: Stefano Govoni; G Salar; F Colombo; Giulio Maria Pasinetti; M Trabucchi; S Mingrino
Episodic secretion of met-enkephalin immunoreactive material in human plasma and CSF.
Pharmacological research communications 1986;18(2):155-9.
1985: L Lucchi; Stefano Govoni; F Battaini; Giulio Maria Pasinetti; Marco Trabucchi
Ethanol administration in vivo alters calcium ions control in rat striatum.
Brain research 1985;332(2):376-9.
1984: Stefano Govoni; Giulio Maria Pasinetti; M R Inzoli; R Rozzini; M Trabucchi
Correlation between beta-endorphin/beta-lipotropin-immunoreactivity and cortisol plasma concentrations.
Life sciences 1984;35(25):2549-52.
1984: Giulio Maria Pasinetti; Stefano Govoni; F Battaini; P Locatelli; E Faccini; M Trabucchi
Caerulein peripheral injection: a study on the correlation with dopaminergic metabolism.
Pharmacological research communications 1984;16(12):1175-82.
1984: U Uzumaki; Stefano Govoni; E Faccini; Giulio Maria Pasinetti; C Missale; Marco Trabucchi
Neuropeptidergic inhibitory regulation of Met-enkephalin immunoreactive material release from rat spinal cord in vitro.
Peptides 1984;5(5):849-52.
1984: Giulio Maria Pasinetti; Stefano Govoni; S di Giovine; P F Spano; Marco Trabucchi
Dopamine enhances Met-enkephalin efflux from rat striatal slices.
Brain research 1984;293(2):364-7.
1984: B I Diamond; Giulio Maria Pasinetti; A Hitri; R L Borison
Extrapyramidal dopamine regulation by cholecystokinin and its role in Parkinson's disease.
Advances in neurology 1984;40():483-8.
1983: Stefano Govoni; Giulio Maria Pasinetti; M Trabucchi; M R Inzoli; R Rozzini
Plasma prolactin concentrations in a large population of healthy old people.
British medical journal (Clinical research ed.) 1983;287(6399):1107.
1983: C Missale; Giulio Maria Pasinetti; Stefano Govoni; P F Spano; M Trabucchi
[Fipexide: a new drug for the regulation of dopaminergic system at the macromolecular level].
Bollettino chimico farmaceutico 1983;122(2):79-85.
1982: Stefano Govoni; H Y Yang; A Bosio; Giulio Maria Pasinetti; E Costa
Possible interaction between cholecystokinin and dopamine.
Advances in biochemical psychopharmacology 1982;33():437-44.
1968: Giulio Maria Pasinetti; G Rampinelli
[Clinical and functional evaluation of long-term outcomes of viral hepatitis in childhood; follow-up of 96 subjects].
Giornale di malattie infettive e parassitarie 1968;20(7):676-9.